Analysis Type: PANTHER Overrepresentation Test (release 20170413) Annotation Version and Release Date: GO Ontology database Released 2017-10-23 Analyzed List: upload_1 (Mus musculus) Reference List: Mus musculus (all genes in database) Bonferroni correction: TRUE Bonferroni count: 8557 GO biological process complete Mus musculus - REFLIST (22262) upload_1 (2513) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (P-value) ribosomal small subunit assembly (GO:0000028) 19 14 2.14 + 6.53 5.69E-04 NADH dehydrogenase complex assembly (GO:0010257) 42 30 4.74 + 6.33 5.55E-11 mitochondrial respiratory chain complex I assembly (GO:0032981) 42 30 4.74 + 6.33 5.55E-11 mitochondrial respiratory chain complex I biogenesis (GO:0097031) 42 30 4.74 + 6.33 5.55E-11 mitochondrial respiratory chain complex assembly (GO:0033108) 71 49 8.01 + 6.11 7.76E-19 mitochondrial ATP synthesis coupled electron transport (GO:0042775) 51 30 5.76 + 5.21 7.14E-09 ATP synthesis coupled electron transport (GO:0042773) 55 30 6.21 + 4.83 4.47E-08 cytochrome complex assembly (GO:0017004) 28 15 3.16 + 4.75 1.05E-02 cytoplasmic translation (GO:0002181) 43 23 4.85 + 4.74 1.83E-05 oxidative phosphorylation (GO:0006119) 61 32 6.89 + 4.65 2.42E-08 ribosome assembly (GO:0042255) 65 32 7.34 + 4.36 1.20E-07 protein targeting to mitochondrion (GO:0006626) 51 25 5.76 + 4.34 2.10E-05 electron transport chain (GO:0022900) 79 38 8.92 + 4.26 3.09E-09 respiratory electron transport chain (GO:0022904) 75 36 8.47 + 4.25 1.35E-08 establishment of protein localization to mitochondrion (GO:0072655) 62 29 7 + 4.14 3.35E-06 ribosomal large subunit assembly (GO:0000027) 35 16 3.95 + 4.05 3.50E-02 protein localization to mitochondrion (GO:0070585) 67 30 7.56 + 3.97 4.60E-06 mitochondrial translation (GO:0032543) 45 20 5.08 + 3.94 3.60E-03 mitochondrial gene expression (GO:0140053) 61 27 6.89 + 3.92 4.14E-05 protein transmembrane import into intracellular organelle (GO:0044743) 43 19 4.85 + 3.91 7.54E-03 translation (GO:0006412) 303 132 34.2 + 3.86 6.49E-34 peptide biosynthetic process (GO:0043043) 322 135 36.35 + 3.71 4.54E-33 ribosomal large subunit biogenesis (GO:0042273) 74 31 8.35 + 3.71 1.13E-05 intracellular protein transmembrane transport (GO:0065002) 54 22 6.1 + 3.61 4.12E-03 protein transmembrane transport (GO:0071806) 55 22 6.21 + 3.54 5.55E-03 purine ribonucleoside triphosphate biosynthetic process (GO:0009206) 49 19 5.53 + 3.44 4.80E-02 cellular respiration (GO:0045333) 133 50 15.01 + 3.33 6.28E-09 ribosomal small subunit biogenesis (GO:0042274) 72 27 8.13 + 3.32 1.13E-03 peptide metabolic process (GO:0006518) 432 160 48.77 + 3.28 1.71E-33 amide biosynthetic process (GO:0043604) 388 142 43.8 + 3.24 7.44E-29 mitochondrion organization (GO:0007005) 374 125 42.22 + 2.96 1.21E-21 ATP metabolic process (GO:0046034) 159 52 17.95 + 2.9 3.29E-07 purine nucleoside triphosphate metabolic process (GO:0009144) 193 62 21.79 + 2.85 9.61E-09 nucleoside triphosphate metabolic process (GO:0009141) 209 67 23.59 + 2.84 1.32E-09 purine ribonucleoside triphosphate metabolic process (GO:0009205) 185 59 20.88 + 2.83 4.44E-08 ribosome biogenesis (GO:0042254) 263 83 29.69 + 2.8 4.05E-12 mitochondrial membrane organization (GO:0007006) 89 28 10.05 + 2.79 1.97E-02 cofactor biosynthetic process (GO:0051188) 128 40 14.45 + 2.77 1.86E-04 ribonucleoside triphosphate metabolic process (GO:0009199) 189 59 21.33 + 2.77 1.02E-07 cellular amide metabolic process (GO:0043603) 562 175 63.44 + 2.76 6.62E-28 mitochondrial transport (GO:0006839) 168 51 18.96 + 2.69 6.12E-06 energy derivation by oxidation of organic compounds (GO:0015980) 192 58 21.67 + 2.68 5.19E-07 purine ribonucleoside monophosphate metabolic process (GO:0009167) 185 55 20.88 + 2.63 2.80E-06 nucleoside monophosphate metabolic process (GO:0009123) 196 58 22.13 + 2.62 1.11E-06 purine nucleoside monophosphate metabolic process (GO:0009126) 186 55 21 + 2.62 3.38E-06 ribonucleoside monophosphate metabolic process (GO:0009161) 188 55 21.22 + 2.59 4.91E-06 rRNA processing (GO:0006364) 176 51 19.87 + 2.57 2.76E-05 ribonucleoprotein complex assembly (GO:0022618) 190 54 21.45 + 2.52 1.86E-05 ribonucleoprotein complex subunit organization (GO:0071826) 201 56 22.69 + 2.47 1.88E-05 generation of precursor metabolites and energy (GO:0006091) 242 66 27.32 + 2.42 1.71E-06 rRNA metabolic process (GO:0016072) 197 53 22.24 + 2.38 1.53E-04 ribonucleoprotein complex biogenesis (GO:0022613) 383 103 43.23 + 2.38 3.69E-11 protein targeting (GO:0006605) 175 45 19.75 + 2.28 5.81E-03 purine nucleotide metabolic process (GO:0006163) 293 74 33.07 + 2.24 3.93E-06 ncRNA processing (GO:0034470) 306 77 34.54 + 2.23 2.06E-06 cellular protein complex assembly (GO:0043623) 346 87 39.06 + 2.23 1.49E-07 cellular macromolecular complex assembly (GO:0034622) 661 166 74.62 + 2.22 9.26E-17 ribonucleotide metabolic process (GO:0009259) 288 72 32.51 + 2.21 1.02E-05 purine ribonucleotide metabolic process (GO:0009150) 280 70 31.61 + 2.21 1.72E-05 nucleotide metabolic process (GO:0009117) 405 98 45.72 + 2.14 6.54E-08 ribose phosphate metabolic process (GO:0019693) 299 72 33.75 + 2.13 4.59E-05 organonitrogen compound biosynthetic process (GO:1901566) 1045 251 117.96 + 2.13 2.76E-24 nucleoside phosphate metabolic process (GO:0006753) 414 99 46.73 + 2.12 9.74E-08 nucleobase-containing small molecule metabolic process (GO:0055086) 458 108 51.7 + 2.09 2.57E-08 purine-containing compound metabolic process (GO:0072521) 336 79 37.93 + 2.08 2.36E-05 oxidation-reduction process (GO:0055114) 843 193 95.16 + 2.03 1.07E-15 cofactor metabolic process (GO:0051186) 306 69 34.54 + 2 1.07E-03 cellular nitrogen compound catabolic process (GO:0044270) 249 55 28.11 + 1.96 3.46E-02 heterocycle catabolic process (GO:0046700) 255 56 28.79 + 1.95 3.36E-02 ncRNA metabolic process (GO:0034660) 407 89 45.94 + 1.94 6.93E-05 organic cyclic compound catabolic process (GO:1901361) 294 63 33.19 + 1.9 1.89E-02 macromolecular complex assembly (GO:0065003) 1256 248 141.78 + 1.75 3.59E-13 RNA processing (GO:0006396) 717 135 80.94 + 1.67 1.18E-04 macromolecular complex subunit organization (GO:0043933) 1418 263 160.07 + 1.64 5.18E-11 protein complex biogenesis (GO:0070271) 936 171 105.66 + 1.62 1.14E-05 protein complex assembly (GO:0006461) 935 170 105.55 + 1.61 1.77E-05 organelle assembly (GO:0070925) 579 105 65.36 + 1.61 2.43E-02 organophosphate metabolic process (GO:0019637) 718 129 81.05 + 1.59 2.97E-03 cellular component biogenesis (GO:0044085) 2201 385 248.46 + 1.55 8.33E-14 small molecule metabolic process (GO:0044281) 1481 259 167.18 + 1.55 4.07E-08 protein complex subunit organization (GO:0071822) 1044 180 117.85 + 1.53 2.40E-04 cellular catabolic process (GO:0044248) 1276 214 144.04 + 1.49 9.40E-05 cellular component assembly (GO:0022607) 1999 334 225.65 + 1.48 6.07E-09 organic substance catabolic process (GO:1901575) 1264 206 142.68 + 1.44 1.38E-03 catabolic process (GO:0009056) 1483 241 167.41 + 1.44 1.43E-04 protein transport (GO:0015031) 1130 179 127.56 + 1.4 4.82E-02 cellular nitrogen compound metabolic process (GO:0034641) 4109 649 463.84 + 1.4 4.32E-16 cellular protein metabolic process (GO:0044267) 2743 424 309.64 + 1.37 1.73E-07 organonitrogen compound metabolic process (GO:1901564) 4326 663 488.33 + 1.36 1.29E-13 organelle organization (GO:0006996) 2784 421 314.27 + 1.34 3.46E-06 cellular metabolic process (GO:0044237) 7165 1058 808.81 + 1.31 1.21E-21 cellular biosynthetic process (GO:0044249) 3412 502 385.16 + 1.3 2.21E-06 gene expression (GO:0010467) 2977 437 336.05 + 1.3 5.96E-05 biosynthetic process (GO:0009058) 3565 522 402.43 + 1.3 1.71E-06 metabolic process (GO:0008152) 8211 1195 926.88 + 1.29 5.18E-24 organic substance biosynthetic process (GO:1901576) 3499 508 394.98 + 1.29 1.07E-05 cellular nitrogen compound biosynthetic process (GO:0044271) 2585 370 291.8 + 1.27 1.24E-02 heterocycle metabolic process (GO:0046483) 3690 520 416.54 + 1.25 3.47E-04 organic cyclic compound metabolic process (GO:1901360) 3933 554 443.97 + 1.25 1.10E-04 cellular aromatic compound metabolic process (GO:0006725) 3742 526 422.41 + 1.25 3.89E-04 protein metabolic process (GO:0019538) 3473 488 392.04 + 1.24 1.48E-03 nitrogen compound metabolic process (GO:0006807) 6836 958 771.67 + 1.24 1.36E-11 organic substance metabolic process (GO:0071704) 7743 1082 874.05 + 1.24 4.97E-14 nucleobase-containing compound metabolic process (GO:0006139) 3560 492 401.86 + 1.22 8.67E-03 primary metabolic process (GO:0044238) 7387 1016 833.87 + 1.22 1.52E-10 cellular macromolecule metabolic process (GO:0044260) 5442 739 614.31 + 1.2 6.89E-05 cellular component organization or biogenesis (GO:0071840) 4854 645 547.93 + 1.18 2.00E-02 macromolecule metabolic process (GO:0043170) 6157 813 695.02 + 1.17 1.06E-03 cellular process (GO:0009987) 13785 1682 1556.09 + 1.08 8.56E-04 biological_process (GO:0008150) 20544 2434 2319.07 + 1.05 3.04E-18 biological regulation (GO:0065007) 11447 1180 1292.17 - 0.91 3.57E-02 regulation of biological process (GO:0050789) 10931 1113 1233.92 - 0.9 6.41E-03 regulation of cellular process (GO:0050794) 10333 1021 1166.42 - 0.88 2.54E-05 response to stimulus (GO:0050896) 7638 718 862.2 - 0.83 3.84E-06 anatomical structure development (GO:0048856) 4815 436 543.53 - 0.8 4.50E-04 cellular developmental process (GO:0048869) 3519 311 397.24 - 0.78 5.73E-03 cellular response to stimulus (GO:0051716) 6046 523 682.49 - 0.77 1.01E-09 cell differentiation (GO:0030154) 3450 296 389.45 - 0.76 4.85E-04 multicellular organism development (GO:0007275) 4524 388 510.68 - 0.76 1.69E-06 animal organ development (GO:0048513) 2813 238 317.54 - 0.75 3.56E-03 system development (GO:0048731) 3961 326 447.13 - 0.73 2.63E-07 regulation of transcription from RNA polymerase II promoter (GO:0006357) 1847 147 208.49 - 0.71 1.60E-02 multicellular organismal process (GO:0032501) 7048 550 795.6 - 0.69 7.08E-24 anatomical structure morphogenesis (GO:0009653) 2041 149 230.39 - 0.65 1.28E-05 epithelium development (GO:0060429) 993 69 112.09 - 0.62 4.65E-02 cell development (GO:0048468) 1547 107 174.63 - 0.61 7.63E-05 embryo development (GO:0009790) 1058 73 119.43 - 0.61 1.74E-02 cell communication (GO:0007154) 5062 342 571.41 - 0.6 3.70E-27 signal transduction (GO:0007165) 4617 310 521.18 - 0.59 1.51E-24 signaling (GO:0023052) 4953 329 559.11 - 0.59 6.24E-28 nervous system development (GO:0007399) 2108 136 237.96 - 0.57 4.01E-10 negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 800 51 90.31 - 0.56 2.95E-02 regulation of neurogenesis (GO:0050767) 829 52 93.58 - 0.56 1.17E-02 cell adhesion (GO:0007155) 757 46 85.45 - 0.54 1.32E-02 cellular component morphogenesis (GO:0032989) 741 45 83.65 - 0.54 1.68E-02 generation of neurons (GO:0048699) 1502 91 169.55 - 0.54 6.14E-08 neurogenesis (GO:0022008) 1602 97 180.84 - 0.54 1.10E-08 biological adhesion (GO:0022610) 767 46 86.58 - 0.53 7.58E-03 regulation of nervous system development (GO:0051960) 925 55 104.42 - 0.53 4.04E-04 tube development (GO:0035295) 628 37 70.89 - 0.52 4.80E-02 animal organ morphogenesis (GO:0009887) 928 54 104.76 - 0.52 1.72E-04 embryonic morphogenesis (GO:0048598) 600 34 67.73 - 0.5 3.03E-02 protein phosphorylation (GO:0006468) 745 42 84.1 - 0.5 1.71E-03 cell-cell signaling (GO:0007267) 794 44 89.63 - 0.49 3.85E-04 head development (GO:0060322) 613 33 69.2 - 0.48 6.57E-03 brain development (GO:0007420) 569 30 64.23 - 0.47 1.01E-02 central nervous system development (GO:0007417) 749 39 84.55 - 0.46 1.36E-04 neuron differentiation (GO:0030182) 949 48 107.13 - 0.45 4.84E-07 neuron development (GO:0048666) 773 38 87.26 - 0.44 1.24E-05 skeletal system development (GO:0001501) 446 21 50.35 - 0.42 1.77E-02 system process (GO:0003008) 2583 120 291.58 - 0.41 4.56E-29 pattern specification process (GO:0007389) 431 20 48.65 - 0.41 2.02E-02 Unclassified (UNCLASSIFIED) 1718 79 193.93 - 0.41 0.00E+00 neuron projection development (GO:0031175) 631 29 71.23 - 0.41 6.90E-05 gland development (GO:0048732) 392 18 44.25 - 0.41 4.90E-02 embryonic organ development (GO:0048568) 465 21 52.49 - 0.4 4.72E-03 cell part morphogenesis (GO:0032990) 460 20 51.93 - 0.39 2.60E-03 cell morphogenesis (GO:0000902) 646 28 72.92 - 0.38 9.17E-06 detection of stimulus (GO:0051606) 466 20 52.6 - 0.38 1.68E-03 nervous system process (GO:0050877) 2114 79 238.63 - 0.33 9.38E-32 G-protein coupled receptor signaling pathway (GO:0007186) 1792 65 202.29 - 0.32 2.99E-27 cell morphogenesis involved in differentiation (GO:0000904) 503 18 56.78 - 0.32 1.17E-05 cell morphogenesis involved in neuron differentiation (GO:0048667) 386 12 43.57 - 0.28 1.11E-04 plasma membrane bounded cell projection morphogenesis (GO:0120039) 431 13 48.65 - 0.27 9.10E-06 cell projection morphogenesis (GO:0048858) 436 13 49.22 - 0.26 5.94E-06 sensory perception (GO:0007600) 1755 50 198.11 - 0.25 2.30E-34 detection of stimulus involved in sensory perception (GO:0050906) 372 9 41.99 - 0.21 5.62E-06 neuron projection morphogenesis (GO:0048812) 426 10 48.09 - 0.21 1.90E-07 axon development (GO:0061564) 329 7 37.14 - < 0.2 1.25E-05 axonogenesis (GO:0007409) 308 6 34.77 - < 0.2 1.70E-05 axon guidance (GO:0007411) 178 3 20.09 - < 0.2 2.39E-02 neuron projection guidance (GO:0097485) 180 3 20.32 - < 0.2 1.96E-02 detection of chemical stimulus (GO:0009593) 330 5 37.25 - < 0.2 3.16E-07 detection of chemical stimulus involved in sensory perception (GO:0050907) 303 3 34.2 - < 0.2 7.17E-08 sensory perception of chemical stimulus (GO:0007606) 1377 10 155.44 - < 0.2 7.94E-51 sensory perception of smell (GO:0007608) 1089 6 122.93 - < 0.2 1.06E-41