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["Table S6. Information about therapeutic targets of drugs with indications for pain (Degrees mean the number of drugs of pain"]
["they are associated with. Numbers in the parentheses are the number of approved drugs of pain they are associated with)."]
["Symbol","Uniprot","Degree"]
["OPRM1","P35372","55(9)"]
["PTGS2","P35354","48(14)"]
["OPRK1","P41145","36(5)"]
["OPRD1","P41143","31(8)"]
["TRPV1","Q8NER1","23(1)"]
["SLC6A4","P31645",23]
["PTGS1","P23219","22(8)"]
["SLC6A2","P23975",21]
["ADRA2A","P08913",18]
["ADRA1A","P35348",17]
["CHRM1","P11229",16]
["HRH1","P35367",15]
["CHRM2","P08172",15]
["DRD2","P14416","14(1)"]
["ADRA1B","P35368",14]
["HTR3A","P46098","13(1)"]
["CHRM3","P20309","13(1)"]
["SCN10A","Q9Y5Y9","13(1)"]
["HTR2A","P28223",13]
["HTR2C","P28335",12]
["ADRA2C","P18825",12]
["HTR1A","P08908",12]
["CNR2","P34972",11]
["ADRA2B","P18089",11]
["ADRA1D","P25100",11]
["CHRM4","P08173",11]
["CHRM5","P08912",10]
["TACR1","P25103",9]
["SCN9A","Q15858",9]
["GRIN3A","Q8TCU5","8(1)"]
["CACNA1B","Q00975","8(1)"]
["HTR1B","P28222",8]
["SLC6A3","Q01959",8]
["SCN5A","Q14524","7(3)"]
["NR3C1","P04150",7]
["CHRNA7","P36544",7]
["CHRNA2","Q15822","7(2)"]
["ADRB1","P08588",7]
["DRD3","P35462",7]
["CHRNA10","Q9GZZ6","6(1)"]
["CNR1","P21554",6]
["GABRA1","P14867",6]
["SIGMAR1","Q99720","6(1)"]
["HTR7","P34969",6]
["HTR6","P50406",6]
["CHRNA4","P43681",6]
["CHRNB2","P17787",6]
["ADRB2","P07550",6]
["OPRL1","P41146",6]
["ESR1","P03372","5(2)"]
["GABRB3","P28472",5]
["GABRB2","P47870",5]
["HTR1D","P28221",5]
["TOP2A","P11388",5]
["HTR2B","P41595",5]
["DRD1","P21728",5]
["SCN11A","Q9UI33",4]
["ALOX5","P09917","4(1)"]
["SCN4A","P35499","4(1)"]
["GABRA2","P47869",4]
["GABRA3","P34903",4]
["CACNA2D1","P54289",4]
["HRH2","P25021",4]
["CHRNA3","P32297",4]
["CHRNB4","P30926",4]
["ADRB3","P13945",4]
["CYP19A1","P11511",4]
["TSPO","P30536",4]
["KCNH2","Q12809",4]
["DRD5","P21918",4]
["DRD4","P21917",4]
["NGFR","P08138",3]
["CACNA1H","O95180",3]
["FAAH","O00519","3(1)"]
["ASIC1","P78348","3(1)"]
["KCNQ2","O43526","3(1)"]
["KCNQ3","O43525","3(1)"]
["PLA2G2A","P14555","3(1)"]
["AR","P10275","3(1)"]
["NOS2","P35228",3]
["BCL2","P10415",3]
["TRPA1","O75762",3]
["GABRA5","P31644",3]
["GABRB1","P18505",3]
["GABRG1","Q8N1C3",3]
["GABRG3","Q99928",3]
["GABRD","O14764",3]
["GABRE","P78334",3]
["GABRP","O00591",3]
["GABRQ","Q9UN88",3]
["ADORA1","P30542",3]
["FDPS","P14324",3]
["ADORA2A","P29274",3]
["HRH4","Q9H3N8",3]
["PTGER4","P35408",3]
["PTGER1","P34995",3]
["CACNG1","Q06432",3]
["CACNA1C","Q13936",3]
["HTR4","Q13639",3]
["CHRNA5","P30532",3]
["CHRNA6","Q15825",3]
["CHRNA9","Q9UGM1",3]
["CHRNB3","Q05901",3]
["HTR1E","P28566",3]
["HRH3","Q9Y5N1",3]
["GLO1","Q04760",2]
["CACNB2","Q08289",2]
["CACNB1","Q02641",2]
["CACNA1S","Q13698",2]
["SCN1A","P35498",2]
["ATP4A","P20648",2]
["MTRR","Q9UBK8",2]
["MTR","Q99707",2]
["SV2A","Q7L0J3",2]
["OXTR","P30559",2]
["GLRA1","P23415",2]
["GRIA1","P42261",2]
["CACNA1D","Q01668",2]
["HMGCR","P04035",2]
["GRIK1","P39086",2]
["BCHE","P06276","2(1)"]
["SSTR1","P30872",2]
["SSTR4","P31391",2]
["MAPK12","P53778",2]
["NTSR1","NTSR1",2]
["P2RX7","Q99572",2]
["MLNR","O43193",2]
["ASIC3","Q9UHC3",2]
["TRHR","P34981",2]
["ADK","P55263",2]
["IKBKB","O14920","2(1)"]
["PGR","P06401","2(2)"]
["ANXA1","P04083",2]
["PPARG","P37231",2]
["CFTR","P13569",2]
["TRPM8","Q7Z2W7",2]
["TRPV3","Q8NET8",2]
["GABRA4","P48169",2]
["GABRA6","Q16445",2]
["GABRG2","P18507",2]
["GABRR1","P24046",2]
["GABRR2","P28476",2]
["GABRR3","A8MPY1",2]
["LTF","P02788",2]
["RYR1","P21817",2]
["TUBB1","Q9H4B7",2]
["MAP2","P11137",2]
["MAP4","P27816",2]
["MAPT","P10636",2]
["NR1I2","O75469",2]
["CALM1","P62158",2]
["NTRK1","P04629",2]
["KCNA1","Q09470",2]
["PADI4","Q9UM07",2]
["PAH","P00439",2]
["TNF","P01375",2]
["RRM1","P23921",2]
["PTGER3","P43115",2]
["SLC12A2","P55011",2]
["SLC12A1","Q13621",2]
["SLC12A5","Q9H2X9",2]
["SLC12A4","Q9UP95",2]
["PTGDR2","Q9Y5Y4",2]
["GRIN1","Q05586",2]
["GRIN2B","Q13224",2]
["GRIN2A","Q12879",2]
["SCN2A","Q99250",2]
["MET","P08581",2]
["KDR","P35968",2]
["RET","O43519",2]
["KIT","P10721",2]
["CD2","P06729","1(1)"]
["KCNQ1","P51787",1]
["MAOA","P21397",1]
["MAOB","P27338",1]
["PTGDR","Q13258",1]
["KCNA5","P22460",1]
["PTPRC","P08575",1]
["TACR2","P21452",1]
["ROCK1","Q13464",1]
["PTAFR","P25105",1]
["SSTR2","P30874",1]
["SSTR3","P32745",1]
["SSTR5","P35346",1]
["COMT","P21964",1]
["PDE7A","Q13946",1]
["PDE7B","Q9NP56",1]
["ACHE","P22303",1]
["INSR","P06213",1]
["CHRNA1","P02708",1]
["CHRNB1","P11230",1]
["CHRNE","Q04844",1]
["CHRND","Q07001",1]
["CHRNG","P07510",1]
["GRM1","Q13255",1]
["GSS","P48637",1]
["GSTM1","P09488",1]
["GSTK1","Q9Y2Q3",1]
["GSTA3","Q16772",1]
["GSTM3","P21266",1]
["GSTA4","O15217",1]
["GSTM4","Q03013",1]
["GSTA5","Q7RTV2",1]
["GSTP1","P09211",1]
["GSTO1","P78417",1]
["GPX1","P07203",1]
["GPX2","P18283",1]
["GSTT1","P30711",1]
["GSTZ1","O43708",1]
["GPX5","O75715",1]
["GPX3","P22352",1]
["LTC4S","Q16873",1]
["MGST3","O14880",1]
["HPGDS","O60760",1]
["TXNDC12","O95881",1]
["GSTA2","P09210",1]
["GSTA1","P08263",1]
["MGST1","P10620",1]
["ESD","P10768",1]
["GGT1","P19440",1]
["GSTM2","P28161",1]
["GLRX","P35754",1]
["GPX4","P36969",1]
["GSTM5","P46439",1]
["GPX6","P59796",1]
["HAGH","Q16775",1]
["GPX8","Q8TED1",1]
["GPX7","Q96SL4",1]
["MGST2","Q99735",1]
["GSTO2","Q9H4Y5",1]
["GLRX2","Q9NS18",1]
["PTGR2","Q8N8N7",1]
["PPARA","Q07869",1]
["HPRT1","P00492",1]
["GABBR1","Q9UBS5",1]
["GABBR2","O75899",1]
["P2RX3","P56373",1]
["BDKRB2","P30411",1]
["IL6R","P08887",1]
["IL6ST","P40189",1]
["BDKRB1","P46663",1]
["IGF1R","P08069",1]
["ESRRA","P11474",1]
["SOD2","P04179",1]
["MME","P08473",1]
["CTSK","P43235",1]
["CTSS","P25774",1]
["AKR1C1","Q04828","1(1)"]
["PRKAA1","Q13131","1(1)"]
["EDNRA","P25101","1(1)"]
["SCN3A","Q9NY46",1]
["TP53","P04637","1(1)"]
["HSPA5","P11021","1(1)"]
["RPS6KA3","P51812","1(1)"]
["NFKBIA","P25963","1(1)"]
["NFKB2","Q00653","1(1)"]
["KCNMA1","Q12791","1(1)"]
["CCKAR","P32238",1]
["CDK1","P06493",1]
["AVP","P01185",1]
["CXCR1","P25024","1(1)"]
["MAPK14","Q16539",1]
["PDPK1","O15530",1]
["NR0B1","P51843",1]
["CALCR","P30988",1]
["THBD","P07204",1]
["PLAT","P00750",1]
["FABP2","P12104",1]
["CREB1","P16220",1]
["TLR4","O00206",1]
["PLA2G2E","Q9NZK7",1]
["RYR2","Q92736",1]
["PPAT","Q06203",1]
["DHFR","P00374",1]
["AHR","P35869",1]
["NPR1","P16066",1]
["TUBB","P07437",1]
["TUBA4A","P68366",1]
["TEK","Q02763",1]
["MT-ND5","P03915",1]
["CYP2D6","P10635",1]
["CYP3A4","P08684",1]
["VDR","P11473",1]
["CD44","P16070",1]
["ICAM1","P05362",1]
["HMMR","O75330",1]
["NCAN","O14594",1]
["VCAN","P13611",1]
["C1QBP","Q07021",1]
["HAPLN1","P10915",1]
["HAPLN4","Q86UW8",1]
["HAPLN3","Q96S86",1]
["HABP2","Q14520",1]
["LAYN","Q6UX15",1]
["STAB2","Q8WWQ8",1]
["IMPG2","Q9BZV3",1]
["TNFAIP6","P98066",1]
["HABP4","Q5JVS0",1]
["METAP2","P50579",1]
["BHMT","Q93088",1]
["BHMT2","Q9H2M3",1]
["CHAT","P28329",1]
["GUCY1A2","P33402",1]
["PRDX5","P30044",1]
["DBH","P09172",1]
["GLRA2","P23416",1]
["GRIA2","P42262",1]
["GRIA4","P48058",1]
["GRIA3","P42263",1]
["KCNJ3","P48549",1]
["DNMT1","P26358",1]
["CACNA2D2","Q9NY47",1]
["MTNR1A","P48039",1]
["MTNR1B","P49286",1]
["RORB","Q92753",1]
["MPO","P05164",1]
["EPX","P11678",1]
["CALR","P27797",1]
["ASMT","P46597",1]
["NQO2","P16083",1]
["HSD11B1","P28845",1]
["GGPS1","O95749",1]
["ADORA2B","P29275",1]
["ADORA3","P0DMS8",1]
["NTRK2","Q16620",1]
["KCND2","Q9NZV8",1]
["KCND3","Q9UK17",1]
["PDE4B","Q07343",1]
["PRKDC","P78527",1]
["PIK3CD","O00329",1]
["PIK3CA","P42336",1]
["PIK3CB","P42338",1]
["ATM","Q13315",1]
["PGRMC1","O00264",1]
["CYBB","P04839",1]
["B2M","P61769",1]
["TYMS","P04818",1]
["CMPK1","P30085",1]
["EGFR","P00533",1]
["FLT3","P36888",1]
["PDGFD","Q9GZP0",1]
["PTGER2","P43116",1]
["GNRHR","P30968",1]
["SLC12A6","Q9UHW9",1]
["SLC12A7","Q9Y666",1]
["CACNA1A","O00555",1]
["ELN","P15502",1]
["GRM5","P41594",1]
["LYZ","P61626",1]
["KCNJ6","P48051",1]
["VCAM1","P19320",1]
["SLC29A1","Q99808",1]
["KCNJ5","P48544",1]
["SLC29A2","Q14542",1]
["HTR3D","Q70Z44",1]
["HTR3E","A5X5Y0",1]
["HTR3B","O95264",1]
["HTR3C","Q8WXA8",1]
["CACNG2","Q9Y698",1]
["KCNJ9","Q92806",1]
["MUT","P22033",1]
["MMAA","Q8IVH4",1]
["TCN1","P20061",1]
["AMN","Q9BXJ7",1]
["CUBN","O60494",1]
["MMAB","Q96EY8",1]
["MMACHC","Q9Y4U1",1]
["GCH1","P30793",1]
["RNASE1","P07998",1]
["PRSS2","P07478",1]
["GM2A","P17900",1]
["CHIT1","Q13231",1]
["AHCY","P23526",1]
["DDX39B","Q13838",1]
["RNGTT","O60942",1]
["GDF5","P43026",1]
["ADI1","Q9BV57",1]
["DCXR","Q7Z4W1",1]
["ACP5","P13686",1]
["PRDX6","P30041",1]
["SLC7A3","Q8WY07",1]
["AZIN2","Q96A70",1]
["ASL","P04424",1]
["SLC7A1","P30825",1]
["ARG2","P78540",1]
["ASS1","P00966",1]
["SLC7A4","O43246",1]
["NOS3","P29474",1]
["ACTA1","P68133",1]
["ATOX1","O00244",1]
["RTCB","Q9Y3I0",1]
["AKR1B1","P15121",1]
["MAPK3","P27361",1]
["PPARD","Q03181",1]
["ATP1A1","P05023",1]
["GRIN2C","Q14957",1]
["GRIN2D","O15399",1]
["APRT","P07741",1]
["MTAP","Q13126",1]
["ACACB","O00763",1]
["ACP1","P24666",1]
["PECR","Q9BY49",1]
["SRPK2","P78362",1]
["SLC22A6","Q4U2R8",1]
["SLC22A8","Q8TCC7",1]
["SLC22A11","Q9NSA0",1]
["SLC22A7","Q9Y694",1]
["SLC15A1","P46059",1]
["ALB","P02768",1]
["SLC15A2","Q16348",1]
["SLC25A4","P12235",1]
["SLC25A5","P05141",1]
["SLC25A6","P12236",1]
["POLA1","P09884",1]
["POLB","P06746",1]
["ABL1","P00519",1]
["SRC","P12931",1]
["EPHA2","P29317",1]
["LCK","P06239",1]
["YES1","P07947",1]
["PDGFRB","P09619",1]
["STAT5B","P51692",1]
["ABL2","P42684",1]
["FYN","P06241",1]
["SMPD1","P17405",1]
["TOP2B","Q02880",1]
["GSR","P00390",1]
["GLT6D1","Q7Z4J2",1]
["GLTP","Q9NZD2",1]
["IL1B","P01584",1]
["VEGFA","P15692",1]
["MMP9","P14780",1]
["CASP1","P29466",1]
["CYCS","P99999",1]
["CASP3","P42574",1]
["PDE1A","P54750",1]
["PDE1B","Q01064",1]
["SLC18A2","Q05940",1]
["SLC18A1","P54219",1]
["HTR5A","P47898",1]
["CES1","P23141",1]
["NEU1","Q99519",1]
["NEU2","Q9Y3R4",1]
["OXT","P01178",1]
["KCNH6","Q9H252",1]
["KCNH7","Q9NS40",1]
["ATP2C1","P98194",1]
["ATP5D","P30049",1]
["MT-ND1","P03886",1]
["ITGB2","P05107",1]
["PRNP","P04156",1]
["CA2","P00918",1]
["CA4","P22748",1]
["ABAT","P80404",1]
["HDAC9","Q9UKV0",1]
["ACADSB","P45954",1]
["OGDH","Q02218",1]
["ALDH5A1","P51649",1]
["HDAC2","Q92769",1]
["AVPR1A","P37288",1]
["AVPR1B","P47901",1]
["AVPR2","P30518",1]