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{"sheet":"Sheet 1 - Table S2","index":0,"n_rows":3509,"n_cols":6,"rows_kept":3509,"cut":false,"hidden":false,"merged":[[0,0,0,5]]}
["Table S2"]
["Table S2. Scores and classifications of Src CD variants. See (Rubin et al 2017) for explanation of \"Standard Error\", \"Epsilon\", and \"Score\" columns. \"Activity Score\" is the inverse of \"Score\". See Methods for \"Classification\" calculation."]
["Variant","Standard Error","Epsilon","Score","Activity Score","Classification"]
["p.Ala309Ser",1.19e-59,2.32e-116,-0.064241699,0.064241699,"neutral"]
["p.Ala314Gly",1.58e-118,8.03e-232,-0.223628608,0.223628608,"neutral"]
["p.Ala330Asn",0.001928089,4.72e-08,0.15008458,-0.15008458,"neutral"]
["p.Ala330Gln",2.89e-07,4.24e-14,0.211651021,-0.211651021,"neutral"]
["p.Ala330Lys",0.946832425,0.011483939,-0.515932547,0.515932547,"neutral"]
["p.Ala330Ser",0.101444333,8.25e-05,0.356329462,-0.356329462,"neutral"]
["p.Ala370Gly",8.89e-23,3.86e-44,-0.007530962,0.007530962,"neutral"]
["p.Ala370Ile",2.41e-10,5.2e-20,-0.08281712400000001,0.08281712400000001,"neutral"]
["p.Ala370Leu",0.341483804,1.39e-17,0.307762957,-0.307762957,"neutral"]
["p.Ala370Met",9.880000000000001e-19,3.1e-36,0.215695017,-0.215695017,"neutral"]
["p.Ala370Ser",6.63e-10,3.97e-19,-0.236157428,0.236157428,"neutral"]
["p.Ala370Val",0.309430812,0,-0.26754804,0.26754804,"neutral"]
["p.Ala371Arg",2.58e-22,3.13e-43,-0.6095105669999999,0.6095105669999999,"neutral"]
["p.Ala371Asp",2.23e-27,4.01e-53,-0.299997924,0.299997924,"neutral"]
["p.Ala371Gln",2.21e-08,3.12e-16,-0.378164339,0.378164339,"neutral"]
["p.Ala371Gly",6.78e-35,7.63e-68,-0.312450054,0.312450054,"neutral"]
["p.Ala371Ile",7.24e-52,4.41e-101,0.359748656,-0.359748656,"neutral"]
["p.Ala371Leu",3.92e-09,1.13e-17,0.178636139,-0.178636139,"neutral"]
["p.Ala371Phe",6.01e-16,7.84e-31,0.103748662,-0.103748662,"neutral"]
["p.Ala371Ser",0.30090657,2.78e-17,0.059106318,-0.059106318,"neutral"]
["p.Ala371Thr",0.601447134,0,-0.49061736,0.49061736,"neutral"]
["p.Ala371Trp",0.828207933,0,-0.09286850100000001,0.09286850100000001,"neutral"]
["p.Ala371Val",0.023937581,3.92e-05,0.138631359,-0.138631359,"neutral"]
["p.Ala374Ile",2.7e-115,1.87e-225,0.45463463,-0.45463463,"neutral"]
["p.Ala374Leu",0.00049998,2.46e-08,0.391090827,-0.391090827,"neutral"]
["p.Ala374Ser",5.84e-07,1.31e-13,-0.378026799,0.378026799,"neutral"]
["p.Ala374Thr",1.43e-11,2.26e-22,0.03970807,-0.03970807,"neutral"]
["p.Ala374Val",1.52e-20,8.829999999999999e-40,0.0750822,-0.0750822,"neutral"]
["p.Ala378Cys",9.83e-17,2.41e-32,-0.518957443,0.518957443,"neutral"]
["p.Ala378His",0.468585489,8.329999999999999e-15,-0.495461203,0.495461203,"neutral"]
["p.Ala378Lys",1.7e-07,1.58e-14,-0.551747324,0.551747324,"neutral"]
["p.Ala378Ser",0.279372275,4.16e-17,-0.523221286,0.523221286,"neutral"]
["p.Ala392Gly",1.71e-30,3.27e-59,0.091092802,-0.091092802,"neutral"]
["p.Ala392Val",3.47e-14,2.1e-27,0.21688523,-0.21688523,"neutral"]
["p.Ala393Glu",9.69e-27,6.91e-52,-0.381370021,0.381370021,"neutral"]
["p.Ala393Val",6.47e-62,8.54e-121,0.440325925,-0.440325925,"neutral"]
["p.Ala421Cys",3.01e-25,5.69e-49,0.460064379,-0.460064379,"neutral"]
["p.Ala425Gly",2.22e-24,2.74e-47,-0.054919959,0.054919959,"neutral"]
["p.Ala425Phe",9.470000000000001e-69,3.34e-134,0.398711212,-0.398711212,"neutral"]
["p.Ala433Glu",2.52e-29,6.15e-57,0.3894608,-0.3894608,"neutral"]
["p.Ala433Gly",1.3e-12,2.28e-24,-0.368804119,0.368804119,"neutral"]
["p.Ala433Ser",4.84e-93,8.01e-182,-0.559582289,0.559582289,"neutral"]
["p.Arg271Ala",1.32e-35,3.02e-69,0.247077672,-0.247077672,"neutral"]
["p.Arg271Asp",0.375712616,0,0.404528845,-0.404528845,"neutral"]
["p.Arg271Gln",0.226492135,0,0.386945172,-0.386945172,"neutral"]
["p.Arg271Gly",1.66e-48,1.67e-94,0.211541371,-0.211541371,"neutral"]
["p.Arg271Lys",4.49e-08,1.06e-15,0.043717502,-0.043717502,"neutral"]
["p.Arg271Ser",0.078270506,1.2e-07,0.315680621,-0.315680621,"neutral"]
["p.Arg271Val",8.9e-08,3.82e-15,0.150181956,-0.150181956,"neutral"]
["p.Arg294Ala",0.188225992,2.08e-17,0.118705217,-0.118705217,"neutral"]
["p.Arg294Asn",4.04e-19,5.36e-37,-0.446386957,0.446386957,"neutral"]
["p.Arg294Asp",0.455097668,0,0.061149868,-0.061149868,"neutral"]
["p.Arg294Cys",0.453249939,2.78e-17,-0.0554942,0.0554942,"neutral"]
["p.Arg294Gln",0.143812165,7.720000000000001e-09,0.266935833,-0.266935833,"neutral"]
["p.Arg294Glu",1.94e-08,2.3e-16,0.129626424,-0.129626424,"neutral"]
["p.Arg294Gly",4.19e-37,3.49e-72,-0.134006062,0.134006062,"neutral"]
["p.Arg294His",7.689999999999999e-06,1.75e-11,-0.324880178,0.324880178,"neutral"]
["p.Arg294Ile",4.62e-16,4.75e-31,-0.353531946,0.353531946,"neutral"]
["p.Arg294Leu",1.15e-21,5.73e-42,-0.345827911,0.345827911,"neutral"]
["p.Arg294Lys",0.299888701,1.47e-13,-0.475052439,0.475052439,"neutral"]
["p.Arg294Met",2.32e-27,4.26e-53,-0.057599237,0.057599237,"neutral"]
["p.Arg294Phe",1.5e-46,1.13e-90,-0.056810453,0.056810453,"neutral"]
["p.Arg294Pro",0.222839131,1.55e-15,-0.240698903,0.240698903,"neutral"]
["p.Arg294Ser",0.364802756,0,-0.17260408,0.17260408,"neutral"]
["p.Arg294Thr",0.612445224,0,-0.233934417,0.233934417,"neutral"]
["p.Arg294Trp",6.52e-05,1.07e-09,-0.302300082,0.302300082,"neutral"]
["p.Arg294Tyr",1.83e-29,3.34e-57,-0.408901688,0.408901688,"neutral"]
["p.Arg294Val",0.24704253,0,-0.09430643399999999,0.09430643399999999,"neutral"]
["p.Arg321Ala",6.959999999999999e-29,4.56e-56,-0.627256124,0.627256124,"neutral"]
["p.Arg321His",8.720000000000001e-05,1.29e-09,-0.567352748,0.567352748,"neutral"]
["p.Arg321Lys",0.94008329,3.33e-16,0.147145237,-0.147145237,"neutral"]
["p.Arg321Met",3e-16,2.2e-31,-0.266288313,0.266288313,"neutral"]
["p.Arg321Phe",0.193612065,2.94e-14,0.263932179,-0.263932179,"neutral"]
["p.Arg321Thr",4.74e-20,7.86e-39,-0.449764614,0.449764614,"neutral"]
["p.Arg321Trp",0.6473658329999999,0,-0.542523391,0.542523391,"neutral"]
["p.Arg321Tyr",7.72e-40,1.56e-77,0.12680722,-0.12680722,"neutral"]
["p.Arg362Lys",3.69e-27,1.05e-52,0.247956139,-0.247956139,"neutral"]
["p.Arg362Met",0.367158171,0,0.252538878,-0.252538878,"neutral"]
["p.Arg362Trp",3.64e-13,1.84e-25,-0.039418151,0.039418151,"neutral"]
["p.Arg362Tyr",1.19e-13,2.25e-26,0.08342928500000001,-0.08342928500000001,"neutral"]
["p.Arg382Ala",2.1e-10,4.24e-20,-0.251760964,0.251760964,"neutral"]
["p.Arg382Asn",3.69e-26,9.5e-51,-0.268142839,0.268142839,"neutral"]
["p.Arg382Gly",3.24e-15,2.06e-29,-0.303281903,0.303281903,"neutral"]
["p.Arg382Ile",2.8e-28,6.820000000000001e-55,0.323506076,-0.323506076,"neutral"]
["p.Arg382Leu",2.33e-08,2.83e-16,-0.142441564,0.142441564,"neutral"]
["p.Arg382Lys",6.15e-42,1.21e-81,-0.157649375,0.157649375,"neutral"]
["p.Arg382Met",2.74e-36,1.39e-70,-0.100314977,0.100314977,"neutral"]
["p.Arg382Ser",3.43e-23,6.16e-45,-0.349630897,0.349630897,"neutral"]
["p.Arg382Thr",4.53e-22,9.600000000000001e-43,-0.455484497,0.455484497,"neutral"]
["p.Arg382Val",3.51e-23,6.289999999999999e-45,-0.36639122,0.36639122,"neutral"]
["p.Arg388Val",0.453976556,2.47e-10,0.412033971,-0.412033971,"neutral"]
["p.Arg422Asn",2.16e-58,6.69e-114,0.440797698,-0.440797698,"neutral"]
["p.Arg422Cys",0.485841759,0,0.236752002,-0.236752002,"neutral"]
["p.Arg422Gly",0.001778103,9.609999999999999e-08,-0.106052902,0.106052902,"neutral"]
["p.Arg422His",9.62e-10,7.71e-19,-0.065728173,0.065728173,"neutral"]
["p.Arg422Lys",3.93e-21,6.07e-41,0.059157257,-0.059157257,"neutral"]
["p.Arg422Pro",0.267890734,2.78e-17,0.030835044,-0.030835044,"neutral"]
["p.Arg422Thr",6.78e-09,3.03e-17,0.181469342,-0.181469342,"neutral"]
["p.Arg441Cys",8.62e-12,8.55e-23,0.269305025,-0.269305025,"neutral"]
["p.Arg441Gly",0.145827728,3.03e-07,-0.183177602,0.183177602,"neutral"]
["p.Arg441His",1.11e-18,3.93e-36,-0.408854591,0.408854591,"neutral"]
["p.Arg441Ile",3.3e-35,1.84e-68,0.114101853,-0.114101853,"neutral"]
["p.Arg441Lys",1.17e-60,2.53e-118,0.308408255,-0.308408255,"neutral"]
["p.Arg441Ser",2.58e-70,2.91e-137,-0.522698157,0.522698157,"neutral"]
["p.Arg441Thr",6.04e-18,1.02e-34,0.189130142,-0.189130142,"neutral"]
["p.Arg441Val",0.195427448,1.39e-17,0.127731048,-0.127731048,"neutral"]
["p.Arg463Ala",0.173926925,9.44e-16,0.094629326,-0.094629326,"neutral"]
["p.Arg463Gln",0.067274209,4.68e-06,-0.211524116,0.211524116,"neutral"]
["p.Arg463Gly",1.57e-32,3.26e-63,0.186238659,-0.186238659,"neutral"]
["p.Arg463His",2.77e-32,9.91e-63,0.294268496,-0.294268496,"neutral"]
["p.Arg463Leu",2.34e-16,1.2e-31,-0.003220098,0.003220098,"neutral"]
["p.Arg463Lys",0.402028095,2.78e-17,0.291934329,-0.291934329,"neutral"]
["p.Arg463Phe",2.94e-17,2.24e-33,0.426890206,-0.426890206,"neutral"]
["p.Arg463Ser",0.032912521,3.52e-05,-0.039181496,0.039181496,"neutral"]
["p.Arg463Thr",5.620000000000001e-17,7.69e-33,0.055684887,-0.055684887,"neutral"]
["p.Arg463Val",0.284867842,3.11e-08,-0.498835626,0.498835626,"neutral"]
["p.Arg472Ala",0.046506852,0,0.216564624,-0.216564624,"neutral"]
["p.Arg472Cys",0.015293858,1.52e-05,-0.188133355,0.188133355,"neutral"]
["p.Arg472Gln",0.247599597,0,-0.193580242,0.193580242,"neutral"]
["p.Arg472Gly",1.95e-09,2.82e-18,0.075790521,-0.075790521,"neutral"]
["p.Arg472His",4.29e-42,6.18e-82,-0.480811432,0.480811432,"neutral"]
["p.Arg472Met",3.74e-17,3.63e-33,-0.496959582,0.496959582,"neutral"]
["p.Arg472Pro",1.36e-09,1.37e-18,-0.333633689,0.333633689,"neutral"]
["p.Arg472Ser",1.38e-86,3.48e-169,0.135540319,-0.135540319,"neutral"]
["p.Arg472Thr",1.59e-08,1.54e-16,0.213780559,-0.213780559,"neutral"]
["p.Arg480Ala",0.093235214,0,0.137132311,-0.137132311,"neutral"]
["p.Arg480Asp",8.82e-32,9.56e-62,0.189914525,-0.189914525,"neutral"]
["p.Arg480Cys",7.82e-20,2.14e-38,0.057815777,-0.057815777,"neutral"]
["p.Arg480Gln",0.126079267,6.94e-18,0.126186773,-0.126186773,"neutral"]
["p.Arg480Glu",2.58e-62,1.39e-121,0.302566409,-0.302566409,"neutral"]
["p.Arg480Gly",1.32e-18,5e-36,0.321986474,-0.321986474,"neutral"]
["p.Arg480His",7.14e-25,3.12e-48,-0.132029337,0.132029337,"neutral"]
["p.Arg480Ile",2.24e-48,2.93e-94,-0.360581638,0.360581638,"neutral"]
["p.Arg480Leu",1.02e-140,2.54e-275,-0.153685867,0.153685867,"neutral"]
["p.Arg480Lys",1.8e-23,1.66e-45,0.179981466,-0.179981466,"neutral"]
["p.Arg480Met",8.64e-09,4.69e-17,-0.202207874,0.202207874,"neutral"]
["p.Arg480Phe",2.31e-25,3.56e-49,-0.185531874,0.185531874,"neutral"]
["p.Arg480Ser",4.93e-82,3.01e-160,0.248263985,-0.248263985,"neutral"]
["p.Arg480Thr",8.25e-32,8.25e-62,0.343420487,-0.343420487,"neutral"]
["p.Arg480Tyr",2.41e-48,3.39e-94,-0.59908354,0.59908354,"neutral"]
["p.Arg480Val",0.112689269,0,0.043286142,-0.043286142,"neutral"]
["p.Arg483Asn",1.68e-19,8.71e-38,0.1006695,-0.1006695,"neutral"]
["p.Arg483Cys",1.64e-16,5.970000000000001e-32,0.197712285,-0.197712285,"neutral"]
["p.Arg483Gln",8.42e-24,3.68e-46,-0.224769748,0.224769748,"neutral"]
["p.Arg483His",8.22e-33,9.109999999999999e-64,-0.451209178,0.451209178,"neutral"]
["p.Arg483Ile",7.39e-36,1.01e-69,-0.255728413,0.255728413,"neutral"]
["p.Arg483Leu",3.05e-24,4.87e-47,-0.056046304,0.056046304,"neutral"]
["p.Arg483Lys",0.22056754,0,-0.070220222,0.070220222,"neutral"]
["p.Arg483Met",9.899999999999999e-17,2.25e-32,0.185420502,-0.185420502,"neutral"]
["p.Arg483Phe",1.17e-08,8.65e-17,0.316444137,-0.316444137,"neutral"]
["p.Arg483Thr",0.26961345,1.39e-17,-0.296814337,0.296814337,"neutral"]
["p.Arg483Tyr",1.01e-57,1.38e-112,0.133059336,-0.133059336,"neutral"]
["p.Arg483Val",9.67e-45,3.84e-87,-0.114231645,0.114231645,"neutral"]
["p.Arg503Ala",0.24431015,2.08e-17,-0.131237754,0.131237754,"neutral"]
["p.Arg503Asn",1.71e-84,4.62e-165,-0.278070039,0.278070039,"neutral"]
["p.Arg503Cys",0.152794279,6.64e-08,-0.18270636,0.18270636,"neutral"]
["p.Arg503Gln",0.117362215,4.8e-08,0.20174167,-0.20174167,"neutral"]
["p.Arg503Glu",0.097698084,6.659999999999999e-11,0.181330916,-0.181330916,"neutral"]
["p.Arg503Gly",2.54e-26,4.12e-51,0.015720248,-0.015720248,"neutral"]
["p.Arg503His",0.16670317,8.43e-09,-0.560718978,0.560718978,"neutral"]
["p.Arg503Ile",4.31e-21,7.62e-41,0.369880307,-0.369880307,"neutral"]
["p.Arg503Leu",0.097001928,2.9e-11,-0.054973274,0.054973274,"neutral"]
["p.Arg503Lys",5.18e-16,6.2e-31,0.058999781,-0.058999781,"neutral"]
["p.Arg503Met",5.92e-15,6.75e-29,0.120448094,-0.120448094,"neutral"]
["p.Arg503Phe",9.849999999999999e-65,2.48e-126,-0.029032956,0.029032956,"neutral"]
["p.Arg503Ser",2.64e-41,2.11e-80,-0.519087105,0.519087105,"neutral"]
["p.Arg503Thr",3.32e-25,6.63e-49,0.052398181,-0.052398181,"neutral"]
["p.Arg503Trp",1.11e-16,2.82e-32,-0.313876127,0.313876127,"neutral"]
["p.Arg503Tyr",0.073853641,5.01e-06,-0.114790078,0.114790078,"neutral"]
["p.Arg503Val",0.239811571,3.82e-16,0.339927987,-0.339927987,"neutral"]
["p.Asn290Ala",2.28e-37,1.07e-72,-0.250344568,0.250344568,"neutral"]
["p.Asn290Arg",0.112693424,3.47e-18,0.15570792,-0.15570792,"neutral"]
["p.Asn290Cys",1.13e-67,4.35e-132,-0.404824547,0.404824547,"neutral"]
["p.Asn290Gln",1.52e-23,1.15e-45,-0.006349465,0.006349465,"neutral"]
["p.Asn290Gly",1.79e-11,3.56e-22,-0.21306765,0.21306765,"neutral"]
["p.Asn290His",0.280425689,0,-0.40540492,0.40540492,"neutral"]
["p.Asn290Leu",3.63e-14,2.15e-27,-0.237981026,0.237981026,"neutral"]
["p.Asn290Met",2e-46,1.91e-90,-0.184259275,0.184259275,"neutral"]
["p.Asn290Ser",0.043889734,2.89e-08,-0.121421134,0.121421134,"neutral"]
["p.Asn290Thr",2.69e-85,1.21e-166,-0.442479805,0.442479805,"neutral"]
["p.Asn290Val",3.5e-43,4.47e-84,-0.396924462,0.396924462,"neutral"]
["p.Asn384Cys",0.193511725,7.03e-13,-0.221287595,0.221287595,"neutral"]
["p.Asn384Gln",4.9e-54,2.41e-105,-0.057908282,0.057908282,"neutral"]
["p.Asn384Gly",8.85e-37,1.55e-71,-0.090868224,0.090868224,"neutral"]
["p.Asn384Leu",1.06e-06,3.81e-13,-0.082878298,0.082878298,"neutral"]
["p.Asn384Met",0.626618687,2.22e-16,-0.153474939,0.153474939,"neutral"]
["p.Asn384Phe",3.81e-22,6.82e-43,-0.060904364,0.060904364,"neutral"]
["p.Asn384Pro",7.87e-30,6.33e-58,0.065050069,-0.065050069,"neutral"]
["p.Asn384Tyr",5.61e-26,2.2e-50,-0.296517838,0.296517838,"neutral"]
["p.Asn400Ile",1.386220582,0,-0.069530543,0.069530543,"neutral"]
["p.Asn417Gln",1.93e-21,1.56e-41,0.358041993,-0.358041993,"neutral"]
["p.Asn417Glu",0.0004980470000000001,1.9e-08,0.052872772,-0.052872772,"neutral"]
["p.Asn417His",0.886227014,0,0.377443259,-0.377443259,"neutral"]
["p.Asn417Ser",2.52e-72,3.27e-141,0.253679007,-0.253679007,"neutral"]
["p.Asn417Thr",9.44e-15,1.61e-28,0.141264338,-0.141264338,"neutral"]
["p.Asp351Ala",3.13e-29,9.47e-57,0.326084523,-0.326084523,"neutral"]
["p.Asp351Asn",3.28e-27,8.36e-53,0.41418078,-0.41418078,"neutral"]
["p.Asp351Cys",1.18e-53,1.3e-104,0.128582187,-0.128582187,"neutral"]
["p.Asp351Gln",9.37e-41,2.49e-79,0.115775168,-0.115775168,"neutral"]
["p.Asp351Glu",0.002205962,4.45e-08,0.015687841,-0.015687841,"neutral"]
["p.Asp351Gly",1.55e-13,3.29e-26,0.161292111,-0.161292111,"neutral"]
["p.Asp351His",0.097493733,1.57e-13,0.033497712,-0.033497712,"neutral"]
["p.Asp351Ile",1.19e-49,9.419999999999999e-97,0.340087847,-0.340087847,"neutral"]
["p.Asp351Phe",0.348591371,0,-0.083143784,0.083143784,"neutral"]
["p.Asp351Ser",1.62e-49,1.67e-96,0.151349585,-0.151349585,"neutral"]
["p.Asp351Thr",4.79e-28,1.94e-54,0.423171512,-0.423171512,"neutral"]
["p.Asp416Thr",5.35e-05,4.95e-10,0.382936677,-0.382936677,"neutral"]
["p.Asp476Tyr",0.334391351,0,0.008023196,-0.008023196,"neutral"]
["p.Asp476Val",9.35e-28,6.99e-54,-0.403235136,0.403235136,"neutral"]
["p.Asp496Leu",2.5e-07,3.05e-14,-0.467587168,0.467587168,"neutral"]
["p.Asp496Val",0.515516658,0,-0.271460339,0.271460339,"neutral"]
["p.Cys280Ala",0.168319072,2.51e-05,-0.295683377,0.295683377,"neutral"]
["p.Cys280His",1.22e-17,4.15e-34,-0.558470975,0.558470975,"neutral"]
["p.Cys280Phe",0.003404057,7.78e-08,0.380870544,-0.380870544,"neutral"]
["p.Cys280Tyr",0.010535484,6.16e-06,-0.513025307,0.513025307,"neutral"]
["p.Cys403Ala",4.45e-34,3e-66,-0.253304069,0.253304069,"neutral"]
["p.Cys403Ile",2.68e-20,2.72e-39,0.09177930400000001,-0.09177930400000001,"neutral"]
["p.Cys403Met",0.031949904,7.07e-05,0.163726021,-0.163726021,"neutral"]
["p.Cys403Ser",2.03e-11,4.58e-22,0.299233342,-0.299233342,"neutral"]
["p.Cys403Tyr",5.1e-91,7.23e-178,0.339278709,-0.339278709,"neutral"]
["p.Cys403Val",1.19e-09,1.15e-18,0.198974266,-0.198974266,"neutral"]
["p.Cys486Ala",0.344253124,6.650000000000001e-08,-0.430253314,0.430253314,"neutral"]
["p.Cys486Arg",3.91e-05,3.41e-10,-0.510867659,0.510867659,"neutral"]
["p.Cys486Gln",0.800366975,0,-0.38281055,0.38281055,"neutral"]
["p.Cys486Glu",1.02e-55,1.24e-108,0.417844102,-0.417844102,"neutral"]
["p.Cys486Gly",4.11e-27,1.35e-52,0.01233743,-0.01233743,"neutral"]
["p.Cys486Leu",1.12e-20,4.8e-40,-0.267875754,0.267875754,"neutral"]
["p.Cys486Lys",0.2243737,2.78e-17,-0.2984941,0.2984941,"neutral"]
["p.Cys486Met",2.02e-27,3.36e-53,0.344614901,-0.344614901,"neutral"]
["p.Cys486Pro",2.29e-06,1.66e-12,-0.320315167,0.320315167,"neutral"]
["p.Cys486Ser",0.640577278,0,-0.014641025,0.014641025,"neutral"]
["p.Cys486Thr",3.26e-24,6.22e-47,-0.413111674,0.413111674,"neutral"]
["p.Cys486Val",4.94e-23,1.25e-44,-0.023222538,0.023222538,"neutral"]
["p.Cys490Ala",7.32e-35,9.17e-68,0.292753679,-0.292753679,"neutral"]
["p.Cys490Ile",9.79e-10,8.16e-19,0.398354783,-0.398354783,"neutral"]
["p.Cys490Leu",0.394863188,2.78e-17,-0.062207584,0.062207584,"neutral"]
["p.Cys490Thr",1.07e-53,1.1e-104,0.138444465,-0.138444465,"neutral"]
["p.Cys490Val",2.56e-14,1.11e-27,0.298562847,-0.298562847,"neutral"]
["p.Cys499Ala",0.001208698,8.54e-08,0.041209074,-0.041209074,"neutral"]
["p.Cys499Arg",1.46e-05,4.91e-11,-0.549272892,0.549272892,"neutral"]
["p.Cys499Gln",2.43e-31,7.02e-61,-0.087477155,0.087477155,"neutral"]
["p.Cys499Gly",4.46e-56,2.34e-109,0.039738014,-0.039738014,"neutral"]
["p.Cys499Leu",0.5172816059999999,0,0.110708022,-0.110708022,"neutral"]
["p.Cys499Met",1.08e-42,3.98e-83,0.224632283,-0.224632283,"neutral"]
["p.Cys499Ser",0.158631454,1.29e-11,0.045192655,-0.045192655,"neutral"]
["p.Cys499Thr",7.59e-09,3.73e-17,0.415493581,-0.415493581,"neutral"]
["p.Cys499Trp",2.24e-05,1.25e-10,0.002633251,-0.002633251,"neutral"]
["p.Cys499Val",0.130910496,0,0.206900803,-0.206900803,"neutral"]
["p.Cys501Ala",2.88e-16,1.87e-31,0.339993562,-0.339993562,"neutral"]
["p.Cys501Asn",1.75e-15,6.809999999999999e-30,-0.260412529,0.260412529,"neutral"]
["p.Cys501Ile",1.82e-27,2.68e-53,0.387292827,-0.387292827,"neutral"]
["p.Cys501Leu",5.01e-34,3.85e-66,-0.283604938,0.283604938,"neutral"]
["p.Cys501Met",3e-39,2.35e-76,0.368407307,-0.368407307,"neutral"]
["p.Cys501Ser",9.41e-06,2.39e-11,-0.117665888,0.117665888,"neutral"]
["p.Cys501Thr",5.35e-63,6.28e-123,0.084210152,-0.084210152,"neutral"]
["p.Cys501Val",2.32e-23,2.8e-45,-0.009366531000000001,0.009366531000000001,"neutral"]
["p.Gln278Ala",7.030000000000001e-11,5.14e-21,-0.12320552,0.12320552,"neutral"]
["p.Gln278Cys",0.116534604,2.17e-09,0.156025821,-0.156025821,"neutral"]
["p.Gln278His",1.6e-06,7.16e-13,0.054206265,-0.054206265,"neutral"]
["p.Gln278Met",9.25e-78,7.29e-152,0.200625768,-0.200625768,"neutral"]
["p.Gln278Phe",4.88e-63,5.28e-123,0.27513906,-0.27513906,"neutral"]
["p.Gln278Ser",2.52e-30,6.63e-59,0.402195004,-0.402195004,"neutral"]
["p.Gln312Arg",6.82e-40,1.24e-77,0.222850281,-0.222850281,"neutral"]
["p.Gln312Asn",1.18e-54,1.46e-106,-0.42287818,0.42287818,"neutral"]
["p.Gln312Asp",0.210069148,0,0.414050618,-0.414050618,"neutral"]
["p.Gln312Glu",7.12e-08,2.5e-15,0.164466124,-0.164466124,"neutral"]
["p.Gln312Gly",9.71e-22,4.29e-42,-0.553902971,0.553902971,"neutral"]
["p.Gln312His",0.143976497,5.9e-17,-0.315869496,0.315869496,"neutral"]
["p.Gln312Met",1.5e-20,8.580000000000001e-40,-0.477976117,0.477976117,"neutral"]
["p.Gln315Ala",0.000140903,2.23e-09,-0.514529483,0.514529483,"neutral"]
["p.Gln315Cys",0.17102609,1.44e-14,0.243255245,-0.243255245,"neutral"]
["p.Gln315Glu",2.52e-13,9.74e-26,-0.439736011,0.439736011,"neutral"]
["p.Gln315Gly",1.2e-30,1.59e-59,-0.210380454,0.210380454,"neutral"]
["p.Gln315His",1.97e-09,2.92e-18,0.013717997,-0.013717997,"neutral"]
["p.Gln315Met",8.35e-15,1.28e-28,0.262736151,-0.262736151,"neutral"]
["p.Gln315Phe",1.41e-71,9.420000000000001e-140,0.436336618,-0.436336618,"neutral"]
["p.Gln315Ser",0.228069311,0,0.060854101,-0.060854101,"neutral"]
["p.Gln315Thr",8.36e-52,5.5e-101,0.209693667,-0.209693667,"neutral"]
["p.Gln315Tyr",0.119952788,9.19e-15,0.08558286700000001,-0.08558286700000001,"neutral"]
["p.Gln327Ala",8.65e-16,1.56e-30,0.189940067,-0.189940067,"neutral"]
["p.Gln327Arg",1.49e-13,3.65e-26,-0.399448794,0.399448794,"neutral"]
["p.Gln327Asn",2.26e-09,3.94e-18,-0.251592864,0.251592864,"neutral"]
["p.Gln327Glu",7.86e-32,7.83e-62,-0.538401174,0.538401174,"neutral"]
["p.Gln327Gly",0.000601781,2.4e-08,0.256616059,-0.256616059,"neutral"]
["p.Gln327His",5.8e-23,1.7e-44,-0.433732638,0.433732638,"neutral"]
["p.Gln327Ile",4.51e-20,7.52e-39,0.327427391,-0.327427391,"neutral"]
["p.Gln327Leu",0.177671882,0,-0.356427885,0.356427885,"neutral"]
["p.Gln327Lys",2.02e-09,3.32e-18,-0.537691343,0.537691343,"neutral"]
["p.Gln327Met",8.78e-29,6.94e-56,0.02063246,-0.02063246,"neutral"]
["p.Gln327Phe",0.269627897,0,0.081656753,-0.081656753,"neutral"]
["p.Gln327Pro",1.54e-17,6.24e-34,-0.096850753,0.096850753,"neutral"]
["p.Gln327Tyr",2.3e-31,6.03e-61,0.289535562,-0.289535562,"neutral"]
["p.Gln327Val",0.03827668,0.000105966,-0.008448246,0.008448246,"neutral"]
["p.Gln365Ser",0.448190735,5.55e-17,-0.191558808,0.191558808,"neutral"]
["p.Gln372Ala",2.37e-46,2.72e-90,-0.146085154,0.146085154,"neutral"]
["p.Gln372Gly",3.04e-54,9.540000000000001e-106,0.100128806,-0.100128806,"neutral"]
["p.Gln372His",8.340000000000001e-08,3.45e-15,0.057577197,-0.057577197,"neutral"]
["p.Gln372Met",1.37e-34,3.04e-67,0.429539515,-0.429539515,"neutral"]
["p.Gln372Ser",0.110011676,0.000285368,0.108151461,-0.108151461,"neutral"]
["p.Gln423Ala",0.055548826,0.000181177,-0.594528227,0.594528227,"neutral"]
["p.Gln423Arg",0.0067711,2.2e-06,0.109038672,-0.109038672,"neutral"]
["p.Gln423Cys",0.094080227,1.08e-13,-0.262782532,0.262782532,"neutral"]
["p.Gln423Glu",2.83e-34,1.26e-66,-0.217997291,0.217997291,"neutral"]
["p.Gln423His",1.28e-37,3.36e-73,0.03956203,-0.03956203,"neutral"]
["p.Gln423Ile",0.067114373,0.000328555,-0.404337669,0.404337669,"neutral"]
["p.Gln423Leu",2.06e-65,1.13e-127,0.173677152,-0.173677152,"neutral"]
["p.Gln423Met",0.037446325,6.56e-06,0.19612076,-0.19612076,"neutral"]
["p.Gln423Ser",0.224816848,6.94e-18,0.330090421,-0.330090421,"neutral"]
["p.Gln423Thr",5.9e-29,3.13e-56,0.299569651,-0.299569651,"neutral"]
["p.Gln423Tyr",5.64e-49,1.88e-95,-0.093064775,0.093064775,"neutral"]
["p.Gln423Val",5.15e-36,4.96e-70,-0.381789975,0.381789975,"neutral"]
["p.Gln477Ala",1.88e-19,1.14e-37,-0.23553538,0.23553538,"neutral"]
["p.Gln477Arg",2.84e-22,3.7e-43,-0.434074367,0.434074367,"neutral"]
["p.Gln477Asn",7.82e-11,5.85e-21,-0.213328816,0.213328816,"neutral"]
["p.Gln477Asp",2.26e-25,3.33e-49,0.294640172,-0.294640172,"neutral"]
["p.Gln477Glu",0.161314561,7.35e-10,-0.322796301,0.322796301,"neutral"]
["p.Gln477Gly",8.52e-07,2.56e-13,0.032576436,-0.032576436,"neutral"]
["p.Gln477His",0.403154646,9.46e-12,0.028669175,-0.028669175,"neutral"]
["p.Gln477Lys",3.72e-13,1.91e-25,-0.200370656,0.200370656,"neutral"]
["p.Gln477Ser",0.160235704,0,-0.032292471,0.032292471,"neutral"]
["p.Gln477Thr",4.02e-13,2.24e-25,-0.1369436,0.1369436,"neutral"]
["p.Gln500Ala",9.639999999999999e-35,1.52e-67,-0.158138046,0.158138046,"neutral"]
["p.Gln500Arg",4.28e-45,7.64e-88,-0.002248757,0.002248757,"neutral"]
["p.Gln500Asp",0.01466163,1.13e-05,-0.431332506,0.431332506,"neutral"]
["p.Gln500Cys",7.56e-15,1.09e-28,-0.302127145,0.302127145,"neutral"]
["p.Gln500Glu",0.18749689,0,-0.065165764,0.065165764,"neutral"]
["p.Gln500Gly",0.000332269,7.74e-09,-0.116371211,0.116371211,"neutral"]
["p.Gln500His",1.84e-19,1.18e-37,-0.440745682,0.440745682,"neutral"]
["p.Gln500Ile",1.47e-16,5.07e-32,-0.333232166,0.333232166,"neutral"]
["p.Gln500Leu",8.949999999999999e-34,1.18e-65,-0.194515535,0.194515535,"neutral"]
["p.Gln500Lys",0.172312207,0,-0.253739004,0.253739004,"neutral"]
["p.Gln500Met",3.8e-18,4.13e-35,-0.131001444,0.131001444,"neutral"]
["p.Gln500Ser",5.84e-08,1.6e-15,0.017003484,-0.017003484,"neutral"]
["p.Gln500Thr",0.537459029,2.98e-10,-0.219081033,0.219081033,"neutral"]
["p.Gln500Tyr",3.21e-35,1.76e-68,-0.340291943,0.340291943,"neutral"]
["p.Gln500Val",2.44e-89,1.44e-174,-0.449687849,0.449687849,"neutral"]
["p.Gln516Ala",0.206748893,6.94e-18,-0.183780977,0.183780977,"neutral"]
["p.Gln516Arg",7.66e-44,2.3e-85,0.035848092,-0.035848092,"neutral"]
["p.Gln516Asp",5.34e-08,1.57e-15,0.416913746,-0.416913746,"neutral"]
["p.Gln516Cys",0.044313091,2.78e-05,0.058976466,-0.058976466,"neutral"]
["p.Gln516Gly",2.05e-44,1.6e-86,-0.232475224,0.232475224,"neutral"]
["p.Gln516His",5.01e-45,1.09e-87,-0.088290075,0.088290075,"neutral"]
["p.Gln516Leu",3.49e-36,2.29e-70,0.206549123,-0.206549123,"neutral"]
["p.Gln516Lys",3.55e-44,5.14e-86,-0.287036833,0.287036833,"neutral"]
["p.Gln516Ser",9.309999999999999e-16,1.89e-30,0.109323562,-0.109323562,"neutral"]
["p.Gln516Thr",2.1e-05,9.35e-11,-0.051533589,0.051533589,"neutral"]
["p.Gln516Val",0.07094995599999999,8.26e-11,-0.08384024700000001,0.08384024700000001,"neutral"]
["p.Glu273Asp",1.51e-10,2.33e-20,0.411993486,-0.411993486,"neutral"]
["p.Glu308Ala",2.13e-65,1.27e-127,-0.343396028,0.343396028,"neutral"]
["p.Glu308Arg",4.05e-20,6.000000000000001e-39,-0.5492848769999999,0.5492848769999999,"neutral"]
["p.Glu308Asp",0.256547753,0,0.44791216,-0.44791216,"neutral"]
["p.Glu308Cys",7.020000000000001e-08,2.5e-15,0.268691979,-0.268691979,"neutral"]
["p.Glu308Gly",6.46e-71,1.77e-138,0.09300996,-0.09300996,"neutral"]
["p.Glu308His",3.05e-42,3.13e-82,-0.583552709,0.583552709,"neutral"]
["p.Glu308Leu",6.83e-15,8.31e-29,-0.150588383,0.150588383,"neutral"]
["p.Glu308Lys",2.21e-14,8.410000000000001e-28,0.146083353,-0.146083353,"neutral"]
["p.Glu308Met",9.03e-10,5.97e-19,-0.023566107,0.023566107,"neutral"]
["p.Glu308Phe",1.98e-07,1.93e-14,-0.250391922,0.250391922,"neutral"]
["p.Glu308Ser",4.47e-26,1.45e-50,-0.324870954,0.324870954,"neutral"]
["p.Glu308Thr",2.53e-08,3.71e-16,0.084582795,-0.084582795,"neutral"]
["p.Glu308Val",8.83e-18,2.12e-34,0.332957583,-0.332957583,"neutral"]
["p.Glu323Ala",0.198806825,0,-0.250209687,0.250209687,"neutral"]
["p.Glu323Asn",2.33e-07,2.5e-14,-0.09531384499999999,0.09531384499999999,"neutral"]
["p.Glu323Asp",0.278070133,0,0.059963838,-0.059963838,"neutral"]
["p.Glu323Cys",6.25e-05,5.12e-10,-0.009730374,0.009730374,"neutral"]
["p.Glu323Gly",1.02e-13,1.59e-26,-0.07799397299999999,0.07799397299999999,"neutral"]
["p.Glu323His",0.025753679,3.82e-05,-0.570237339,0.570237339,"neutral"]
["p.Glu323Ile",1.86e-18,9.82e-36,-0.073965431,0.073965431,"neutral"]
["p.Glu323Leu",0.06797655,2.02e-10,-0.108311119,0.108311119,"neutral"]
["p.Glu323Phe",0.002539832,3.87e-08,-0.212628423,0.212628423,"neutral"]
["p.Glu323Pro",3.4e-95,4.77e-186,-0.404631799,0.404631799,"neutral"]
["p.Glu323Ser",1.08e-156,1.16e-306,-0.125802424,0.125802424,"neutral"]
["p.Glu323Thr",0.005472216,3.78e-07,-0.205384414,0.205384414,"neutral"]
["p.Glu323Trp",6.489999999999999e-67,1.34e-130,-0.354351601,0.354351601,"neutral"]
["p.Glu323Tyr",6.08e-27,2.78e-52,-0.334651549,0.334651549,"neutral"]
["p.Glu323Val",3.82e-43,5.06e-84,-0.148264001,0.148264001,"neutral"]
["p.Glu334Ala",1.46e-49,1.39e-96,0.18586038,-0.18586038,"neutral"]
["p.Glu334Arg",1.65e-34,4.32e-67,-0.344380662,0.344380662,"neutral"]
["p.Glu334Asn",2.19e-39,1.21e-76,0.177826956,-0.177826956,"neutral"]
["p.Glu334Gln",0.515509662,5.55e-17,-0.037970898,0.037970898,"neutral"]
["p.Glu334His",3.53e-19,4.18e-37,-0.059228366,0.059228366,"neutral"]
["p.Glu334Ile",0.390943734,0,-0.550120619,0.550120619,"neutral"]
["p.Glu334Leu",0.349592251,3.76e-10,-0.597151954,0.597151954,"neutral"]
["p.Glu334Lys",2.99e-41,2.71e-80,-0.36304776,0.36304776,"neutral"]
["p.Glu334Pro",2.34e-33,7.94e-65,-0.479658798,0.479658798,"neutral"]
["p.Glu334Ser",0.09100713000000001,0,0.166958138,-0.166958138,"neutral"]
["p.Glu334Thr",9.91e-32,1.19e-61,-0.176161822,0.176161822,"neutral"]
["p.Glu334Trp",5.6e-46,1.51e-89,-0.037910216,0.037910216,"neutral"]
["p.Glu334Tyr",2.33e-46,2.71e-90,-0.6201548730000001,0.6201548730000001,"neutral"]
["p.Glu334Val",2.25e-35,8.6e-69,-0.374624977,0.374624977,"neutral"]
["p.Glu335Gly",0.312855704,1.39e-17,0.053322406,-0.053322406,"neutral"]
["p.Glu335Pro",3.02e-09,6.950000000000001e-18,-0.400228912,0.400228912,"neutral"]
["p.Glu356Ala",6.43e-20,1.39e-38,-0.256871398,0.256871398,"neutral"]
["p.Glu356Asp",1.49e-40,6.05e-79,0.145565714,-0.145565714,"neutral"]
["p.Glu356Cys",2.01e-09,3.39e-18,-0.171712257,0.171712257,"neutral"]
["p.Glu356Gln",4.45e-06,7.340000000000001e-12,-0.097052651,0.097052651,"neutral"]
["p.Glu356Gly",1.06e-53,1.07e-104,-0.621482028,0.621482028,"neutral"]
["p.Glu356His",3.41e-54,1.16e-105,-0.441377543,0.441377543,"neutral"]
["p.Glu356Leu",9.29e-10,6.65e-19,-0.375485299,0.375485299,"neutral"]
["p.Glu356Lys",0.089548249,5.46e-05,-0.537826375,0.537826375,"neutral"]
["p.Glu356Phe",5.26e-27,2.1e-52,-0.514794671,0.514794671,"neutral"]
["p.Glu356Pro",7.73e-08,3.06e-15,-0.426498043,0.426498043,"neutral"]
["p.Glu356Ser",1.58e-17,6.51e-34,-0.305557888,0.305557888,"neutral"]
["p.Glu356Thr",1.23e-33,2.26e-65,-0.503919653,0.503919653,"neutral"]
["p.Glu356Tyr",4.07e-13,2.38e-25,-0.305972997,0.305972997,"neutral"]
["p.Glu356Val",4.05e-16,3.66e-31,-0.500782627,0.500782627,"neutral"]
["p.Glu399Cys",1.97e-40,1.11e-78,-0.619675787,0.619675787,"neutral"]
["p.Glu399Ile",1.52e-07,1.2e-14,-0.448971071,0.448971071,"neutral"]
["p.Glu399Met",0.116202293,1.78e-06,-0.224850075,0.224850075,"neutral"]
["p.Glu399Thr",2.26e-32,6.89e-63,-0.355440772,0.355440772,"neutral"]
["p.Glu399Tyr",4.74e-32,2.97e-62,-0.598854817,0.598854817,"neutral"]
["p.Glu399Val",0.258684899,1.39e-16,-0.306553995,0.306553995,"neutral"]
["p.Glu415Arg",6.47e-81,4.75e-158,0.151415941,-0.151415941,"neutral"]
["p.Glu415Cys",3.06e-39,2.44e-76,0.26317417,-0.26317417,"neutral"]
["p.Glu415Gln",3.95e-31,1.77e-60,0.43773405,-0.43773405,"neutral"]
["p.Glu415His",7.06e-15,9.66e-29,0.300494142,-0.300494142,"neutral"]
["p.Glu415Ile",4.43e-25,1.28e-48,0.044313619,-0.044313619,"neutral"]
["p.Glu415Leu",4.23e-32,2.36e-62,0.274316068,-0.274316068,"neutral"]
["p.Glu415Pro",2.47e-21,2.54e-41,-0.025162999,0.025162999,"neutral"]
["p.Glu418Ala",3.52e-14,2.22e-27,-0.393933299,0.393933299,"neutral"]
["p.Glu418Gln",9.27e-37,1.72e-71,0.101925533,-0.101925533,"neutral"]
["p.Glu418His",0.112810467,6.81e-05,0.322652672,-0.322652672,"neutral"]
["p.Glu418Ile",0.216196766,4.69e-06,-0.490444652,0.490444652,"neutral"]
["p.Glu418Leu",5.43e-11,3.03e-21,0.38020609,-0.38020609,"neutral"]
["p.Glu418Met",1.58e-147,1.14e-288,0.195199311,-0.195199311,"neutral"]
["p.Glu418Tyr",0.366356765,1.19e-15,-0.546802923,0.546802923,"neutral"]
["p.Glu473Leu",0.117778096,0.000504007,0.327640557,-0.327640557,"neutral"]
["p.Glu479Ala",1.47e-09,1.75e-18,-0.479878718,0.479878718,"neutral"]
["p.Glu479Arg",1.13e-10,1.25e-20,0.276833043,-0.276833043,"neutral"]
["p.Glu479Asn",1.43e-51,1.62e-100,0.207784764,-0.207784764,"neutral"]
["p.Glu479Asp",0.007369512,2.61e-06,0.272193189,-0.272193189,"neutral"]
["p.Glu479Cys",0.094741702,0,0.183732736,-0.183732736,"neutral"]
["p.Glu479Gln",1.27e-90,4.38e-177,0.274611285,-0.274611285,"neutral"]
["p.Glu479Ile",1.04e-08,7.18e-17,0.259613342,-0.259613342,"neutral"]
["p.Glu479Lys",0.670372507,1.11e-16,0.222957826,-0.222957826,"neutral"]
["p.Glu479Phe",0.238428759,6.94e-18,0.170387983,-0.170387983,"neutral"]
["p.Glu479Pro",1.16e-09,1.07e-18,-0.573473264,0.573473264,"neutral"]
["p.Glu479Ser",9.71e-12,1.1e-22,-0.160154362,0.160154362,"neutral"]
["p.Glu479Thr",7.44e-09,3.62e-17,0.191517402,-0.191517402,"neutral"]
["p.Glu479Tyr",3.99e-47,8.319999999999999e-92,-0.273792155,0.273792155,"neutral"]
["p.Glu479Val",1.04e-11,1.24e-22,0.374293487,-0.374293487,"neutral"]
["p.Glu489Ala",0.476245818,3.72e-12,-0.166628992,0.166628992,"neutral"]
["p.Glu489Arg",1.94e-26,2.73e-51,-0.094037671,0.094037671,"neutral"]
["p.Glu489Asn",0.134827298,2.8e-15,0.174868745,-0.174868745,"neutral"]
["p.Glu489Asp",0.004438925,3.61e-07,0.142414184,-0.142414184,"neutral"]
["p.Glu489Cys",0.58756544,0,-0.006873133,0.006873133,"neutral"]
["p.Glu489Gly",1.2e-51,1.14e-100,0.052068172,-0.052068172,"neutral"]
["p.Glu489Ile",6.08e-32,4.69e-62,0.342582253,-0.342582253,"neutral"]
["p.Glu489Met",1.37e-18,5.8e-36,0.153064013,-0.153064013,"neutral"]
["p.Glu489Ser",1.34e-06,6.69e-13,0.236719972,-0.236719972,"neutral"]
["p.Glu489Thr",3.53e-23,6.58e-45,0.431431605,-0.431431605,"neutral"]
["p.Glu489Tyr",1.3e-08,1.13e-16,-0.15215634,0.15215634,"neutral"]
["p.Glu492Ala",0.155141952,6.94e-18,-0.224783262,0.224783262,"neutral"]
["p.Glu492Asn",3.79e-13,2.13e-25,0.078040632,-0.078040632,"neutral"]
["p.Glu492Gly",0.471373237,0,-0.051777381,0.051777381,"neutral"]
["p.Glu492Lys",1.37e-116,5.39e-228,-0.368210371,0.368210371,"neutral"]
["p.Glu492Met",9.37e-17,2.22e-32,-0.356269599,0.356269599,"neutral"]
["p.Glu492Pro",0.619712897,1.11e-16,-0.163492572,0.163492572,"neutral"]
["p.Glu492Thr",0.110301999,6.08e-09,-0.218290471,0.218290471,"neutral"]
["p.Glu492Val",0.116178643,1.65e-07,-0.180690906,0.180690906,"neutral"]
["p.Glu505Ala",1.3e-33,2.41e-65,-0.293641705,0.293641705,"neutral"]
["p.Glu505Arg",0.000525686,2.66e-08,-0.12760658,0.12760658,"neutral"]
["p.Glu505Asn",3.95e-43,5.65e-84,-0.400119749,0.400119749,"neutral"]
["p.Glu505Asp",1.55e-13,3.61e-26,0.004020794,-0.004020794,"neutral"]
["p.Glu505Cys",9.649999999999999e-22,4.09e-42,-0.409186332,0.409186332,"neutral"]
["p.Glu505Gln",4.29e-65,5.05e-127,-0.623850593,0.623850593,"neutral"]
["p.Glu505Gly",6.62e-18,1.16e-34,-0.187787774,0.187787774,"neutral"]
["p.Glu505His",9.91e-15,1.88e-28,-0.583638266,0.583638266,"neutral"]
["p.Glu505Ile",1.36e-12,2.44e-24,-0.190128508,0.190128508,"neutral"]
["p.Glu505Leu",0.141513603,1.15e-08,-0.390671752,0.390671752,"neutral"]
["p.Glu505Lys",0.312774502,0,-0.148639827,0.148639827,"neutral"]
["p.Glu505Phe",8.31e-13,9.999999999999999e-25,0.072698587,-0.072698587,"neutral"]
["p.Glu505Pro",0.15252351,0,-0.145207729,0.145207729,"neutral"]
["p.Glu505Ser",0.219452133,7.66e-13,-0.341931764,0.341931764,"neutral"]
["p.Glu505Thr",1.06e-17,2.92e-34,-0.308253077,0.308253077,"neutral"]
["p.Glu505Tyr",8.07e-50,4.35e-97,-0.498380875,0.498380875,"neutral"]
["p.Glu505Val",2.15e-26,3.27e-51,-0.262435366,0.262435366,"neutral"]
["p.Glu507Ala",0.356683049,0,-0.249617582,0.249617582,"neutral"]
["p.Glu507Arg",2.35e-30,5.84e-59,-0.566120797,0.566120797,"neutral"]
["p.Glu507Asn",1.57e-35,4.5e-69,0.100010022,-0.100010022,"neutral"]
["p.Glu507Asp",0.574204238,0,-0.567808088,0.567808088,"neutral"]
["p.Glu507Gly",1.15e-34,2.12e-67,-0.134433892,0.134433892,"neutral"]
["p.Glu507His",0.110664563,0,-0.255436212,0.255436212,"neutral"]
["p.Glu507Leu",2.57e-35,1.15e-68,-0.261010173,0.261010173,"neutral"]
["p.Glu507Met",7.13e-18,1.41e-34,0.060840948,-0.060840948,"neutral"]
["p.Glu507Pro",6.24e-26,2.69e-50,-0.454988251,0.454988251,"neutral"]
["p.Glu507Ser",0.008200756999999999,2.72e-07,-0.317166374,0.317166374,"neutral"]
["p.Glu507Thr",0.346440507,1.39e-17,0.054103193,-0.054103193,"neutral"]
["p.Glu507Trp",2e-17,1.07e-33,-0.564979071,0.564979071,"neutral"]
["p.Glu508Ala",6.47e-30,4.25e-58,-0.216385733,0.216385733,"neutral"]
["p.Glu508Asn",0.000458564,8.51e-09,-0.12903765,0.12903765,"neutral"]
["p.Glu508Gln",0.037230642,9.99e-05,-0.531826997,0.531826997,"neutral"]
["p.Glu508Gly",0.141627405,1.39e-17,-0.465415244,0.465415244,"neutral"]
["p.Glu508Ile",3.35e-30,1.18e-58,-0.346537973,0.346537973,"neutral"]
["p.Glu508Leu",7.41e-12,6.66e-23,-0.351067403,0.351067403,"neutral"]
["p.Glu508Lys",3.24e-14,1.89e-27,-0.56155195,0.56155195,"neutral"]
["p.Glu508Met",0.269458059,1.57e-06,-0.401341943,0.401341943,"neutral"]
["p.Glu508Ser",0.133308085,3.47e-18,-0.08366802299999999,0.08366802299999999,"neutral"]
["p.Glu508Thr",3.1e-12,1.19e-23,-0.245327083,0.245327083,"neutral"]
["p.Glu508Val",1.54e-51,1.84e-100,-0.247721209,0.247721209,"neutral"]
["p.Glu513Asn",4.67e-14,3.65e-27,-0.514709839,0.514709839,"neutral"]
["p.Glu513Asp",3.27e-18,3.1e-35,-0.16620181,0.16620181,"neutral"]
["p.Glu513Cys",1.49e-28,1.88e-55,0.036534057,-0.036534057,"neutral"]
["p.Glu513Gln",0.321157352,0,0.195791114,-0.195791114,"neutral"]
["p.Glu513Gly",2.03e-32,5.06e-63,-0.300968612,0.300968612,"neutral"]
["p.Glu513His",0.194722001,0,-0.053178982,0.053178982,"neutral"]
["p.Glu513Leu",0.374101299,0,0.292118467,-0.292118467,"neutral"]
["p.Glu513Lys",2.58e-24,3.83e-47,-0.162857949,0.162857949,"neutral"]
["p.Glu513Phe",0.769032539,0,-0.009766136999999999,0.009766136999999999,"neutral"]
["p.Glu513Ser",3.56e-23,6.18e-45,-0.233074182,0.233074182,"neutral"]
["p.Glu513Trp",3.2e-05,2.37e-10,-0.580210886,0.580210886,"neutral"]
["p.Glu513Val",1.97e-11,4.46e-22,-0.461049545,0.461049545,"neutral"]
["p.Gly287Ala",0.163985303,6.71e-07,-0.627657449,0.627657449,"neutral"]
["p.Gly287Cys",0.135167807,7.52e-14,0.26001152,-0.26001152,"neutral"]
["p.Gly287Met",0.323471625,0,0.14222368,-0.14222368,"neutral"]
["p.Gly287Thr",0.055754615,7.2e-05,0.257915651,-0.257915651,"neutral"]
["p.Gly287Tyr",0.28730051,4.37e-13,-0.348567343,0.348567343,"neutral"]
["p.Gly291Ala",1.22e-34,2.37e-67,-0.370100895,0.370100895,"neutral"]
["p.Gly291Arg",1.51e-07,1.09e-14,-0.164130816,0.164130816,"neutral"]
["p.Gly291Asn",5.07e-06,8.62e-12,-0.037742982,0.037742982,"neutral"]
["p.Gly291Asp",9.760000000000001e-16,2.08e-30,-0.138499197,0.138499197,"neutral"]
["p.Gly291Cys",4.29e-47,9.96e-92,0.08280767999999999,-0.08280767999999999,"neutral"]
["p.Gly291Gln",4.96e-32,2.94e-62,-0.023495511,0.023495511,"neutral"]
["p.Gly291Glu",2.4e-26,4.12e-51,-0.030993865,0.030993865,"neutral"]
["p.Gly291His",0.005285643,7.57e-08,-0.154924294,0.154924294,"neutral"]
["p.Gly291Ile",6.15e-106,4.04e-207,0.122829832,-0.122829832,"neutral"]
["p.Gly291Leu",4.65e-16,4.77e-31,-0.194574626,0.194574626,"neutral"]
["p.Gly291Met",0.006465091,3.62e-08,-0.026648104,0.026648104,"neutral"]
["p.Gly291Ser",4.2e-16,3.54e-31,-0.069910439,0.069910439,"neutral"]
["p.Gly291Val",0.000157293,2.61e-09,-0.277643089,0.277643089,"neutral"]
["p.Gly303Leu",0.178738808,0,-0.019340811,0.019340811,"neutral"]
["p.Gly347Arg",0.385823769,0,-0.04371402,0.04371402,"neutral"]
["p.Gly347Asn",0.16489638,1.19e-08,0.220244173,-0.220244173,"neutral"]
["p.Gly347Cys",0.162406805,4.42e-09,0.275529742,-0.275529742,"neutral"]
["p.Gly347Leu",0.055242969,0,0.039164347,-0.039164347,"neutral"]
["p.Gly347Lys",3.77e-17,3.61e-33,0.059550171,-0.059550171,"neutral"]
["p.Gly347Ser",1.22e-36,2.75e-71,0.063608888,-0.063608888,"neutral"]
["p.Gly355Ala",4.4e-13,2.56e-25,0.134796969,-0.134796969,"neutral"]
["p.Gly355Arg",2.05e-07,1.82e-14,-0.191980122,0.191980122,"neutral"]
["p.Gly355Asn",0.003561303,3.3e-07,0.286514708,-0.286514708,"neutral"]
["p.Gly355Cys",0.255785181,0,-0.226646726,0.226646726,"neutral"]
["p.Gly355Gln",1.79e-40,9.000000000000001e-79,0.237242328,-0.237242328,"neutral"]
["p.Gly355Glu",0.030668308,2.54e-05,0.032487766,-0.032487766,"neutral"]
["p.Gly355His",1.56e-48,1.42e-94,-0.398375921,0.398375921,"neutral"]
["p.Gly355Ile",0.00057031,1.82e-08,0.149640923,-0.149640923,"neutral"]
["p.Gly355Leu",9.08e-07,2.96e-13,0.125406612,-0.125406612,"neutral"]
["p.Gly355Lys",0.156862935,4.12e-06,0.037702163,-0.037702163,"neutral"]
["p.Gly355Phe",0.481721517,0,-0.249419217,0.249419217,"neutral"]
["p.Gly355Pro",4.64e-14,3.3e-27,0.075131827,-0.075131827,"neutral"]
["p.Gly355Ser",1.87e-24,2.03e-47,-0.190487317,0.190487317,"neutral"]
["p.Gly355Thr",0.109573658,3.47e-18,0.024806569,-0.024806569,"neutral"]
["p.Gly355Trp",1.33e-20,6.88e-40,-0.146416321,0.146416321,"neutral"]
["p.Gly355Val",2.1e-48,2.55e-94,0.276532212,-0.276532212,"neutral"]
["p.Gly358Trp",0.17862851,0,-0.000943394,0.000943394,"neutral"]
["p.Gly358Val",3.1e-15,1.99e-29,0.109580526,-0.109580526,"neutral"]
["p.Gly398Ala",1.33e-20,7.07e-40,0.363230303,-0.363230303,"neutral"]
["p.Gly398Arg",1.02e-07,5.45e-15,-0.590611425,0.590611425,"neutral"]
["p.Gly398Glu",3.15e-47,5.34e-92,0.388977634,-0.388977634,"neutral"]
["p.Gly398His",6.95e-75,3.01e-146,-0.288932656,0.288932656,"neutral"]
["p.Gly398Met",9.45e-15,1.56e-28,-0.097412337,0.097412337,"neutral"]
["p.Gly398Ser",3.78e-16,3.16e-31,-0.435985582,0.435985582,"neutral"]
["p.Gly398Thr",0.225128259,0,-0.08802225599999999,0.08802225599999999,"neutral"]
["p.Gly424Asp",2.6e-20,2.48e-39,0.294664721,-0.294664721,"neutral"]
["p.Gly440Arg",7.96e-05,9.89e-10,0.289256148,-0.289256148,"neutral"]
["p.Gly440His",1.1e-24,7.26e-48,0.039436337,-0.039436337,"neutral"]
["p.Gly440Met",1.63e-23,1.4e-45,-0.34680124,0.34680124,"neutral"]
["p.Gly440Phe",1.26e-09,1.31e-18,-0.327421085,0.327421085,"neutral"]
["p.Gly440Trp",0.337807014,1.39e-17,0.140237741,-0.140237741,"neutral"]
["p.Gly468Ala",5.73e-21,1.38e-40,-0.5839288419999999,0.5839288419999999,"neutral"]
["p.Gly468Asp",0.128940582,3.47e-18,0.07183761700000001,-0.07183761700000001,"neutral"]
["p.Gly468Thr",0.64636952,2.22e-16,-0.173431677,0.173431677,"neutral"]
["p.Gly481Asn",0.245204007,0,0.27210274,-0.27210274,"neutral"]
["p.Gly481Asp",5.79e-35,5.58e-68,0.345806459,-0.345806459,"neutral"]
["p.His495Ala",1.85e-19,1.12e-37,-0.041150804,0.041150804,"neutral"]
["p.His495Arg",8.260000000000001e-12,7.79e-23,-0.05120058,0.05120058,"neutral"]
["p.His495Asn",2.95e-30,9.020000000000001e-59,-0.288943591,0.288943591,"neutral"]
["p.His495Asp",1.16e-18,4.08e-36,-0.004324175,0.004324175,"neutral"]
["p.His495Cys",1.14e-24,7.97e-48,0.249121287,-0.249121287,"neutral"]
["p.His495Gln",0.362322074,3.89e-16,0.105823766,-0.105823766,"neutral"]
["p.His495Glu",0.125261294,3.74e-12,0.191920169,-0.191920169,"neutral"]
["p.His495Gly",2.98e-06,2.34e-12,-0.021096165,0.021096165,"neutral"]
["p.His495Lys",0.099109067,9.5e-08,-0.255662456,0.255662456,"neutral"]
["p.His495Met",3.68e-07,5.84e-14,0.06456524499999999,-0.06456524499999999,"neutral"]
["p.His495Ser",0.166575107,0,-0.107903087,0.107903087,"neutral"]
["p.His495Thr",7.8e-37,1.23e-71,0.326288367,-0.326288367,"neutral"]
["p.His495Trp",2.54e-26,4.69e-51,0.065928635,-0.065928635,"neutral"]
["p.Ile297Cys",0.000324801,2.12e-08,-0.475024884,0.475024884,"neutral"]
["p.Ile297Gly",1.56e-12,3.27e-24,-0.281915185,0.281915185,"neutral"]
["p.Ile297Leu",0.29308749,0,0.054048341,-0.054048341,"neutral"]
["p.Ile297Phe",0.076931347,4.47e-07,0.186413049,-0.186413049,"neutral"]
["p.Ile297Ser",1.01e-07,5.22e-15,-0.582269864,0.582269864,"neutral"]
["p.Ile297Thr",1.57e-26,1.81e-51,-0.511232445,0.511232445,"neutral"]
["p.Ile297Tyr",0.198491837,0,-0.038643135,0.038643135,"neutral"]
["p.Ile297Val",1.07e-24,6.86e-48,-0.530795541,0.530795541,"neutral"]
["p.Ile337Gly",4.31e-11,2.09e-21,0.140347122,-0.140347122,"neutral"]
["p.Ile337Met",0.538124071,1.02e-14,0.260209711,-0.260209711,"neutral"]
["p.Ile337Ser",0.121480797,0.000139568,0.111719281,-0.111719281,"neutral"]
["p.Ile339His",0.100514998,2.26e-08,-0.315914374,0.315914374,"neutral"]
["p.Ile339Leu",0.082899661,0.000272869,0.299164548,-0.299164548,"neutral"]
["p.Ile373Cys",6.2e-12,4.65e-23,0.384256922,-0.384256922,"neutral"]
["p.Ile373Val",0.209088322,0,0.241338741,-0.241338741,"neutral"]
["p.Ile395Cys",2.67e-05,1.74e-10,-0.12833375,0.12833375,"neutral"]
["p.Ile395Met",0.238531722,1.39e-17,0.327759414,-0.327759414,"neutral"]
["p.Ile414Val",4.98e-51,1.89e-99,0.038074213,-0.038074213,"neutral"]
["p.Ile429Leu",1.85e-06,1.17e-12,0.366858825,-0.366858825,"neutral"]
["p.Ile429Phe",0.792938563,0,-0.295534492,0.295534492,"neutral"]
["p.Ile429Tyr",0.349643251,6.469999999999999e-11,-0.043717028,0.043717028,"neutral"]
["p.Ile444Asn",0.672711272,0,-0.431056504,0.431056504,"neutral"]
["p.Ile453Cys",8.879999999999999e-21,3.17e-40,-0.117646173,0.117646173,"neutral"]
["p.Ile453Tyr",8.73e-44,3.04e-85,0.131483199,-0.131483199,"neutral"]
["p.Ile453Val",3.92e-44,6.01e-86,-0.301731697,0.301731697,"neutral"]
["p.Leu270Thr",2.95e-44,3.67e-86,-0.5005525830000001,0.5005525830000001,"neutral"]
["p.Leu276Arg",1.43e-06,7.89e-13,-0.081400287,0.081400287,"neutral"]
["p.Leu276Asp",1.02e-52,9.249999999999999e-103,-0.381816431,0.381816431,"neutral"]
["p.Leu276Glu",0.327348668,2.78e-17,0.163047467,-0.163047467,"neutral"]
["p.Leu276Tyr",0.513593657,1.11e-16,0.205315608,-0.205315608,"neutral"]
["p.Leu300Ala",0.006047109,1.69e-06,-0.279215063,0.279215063,"neutral"]
["p.Leu300Asp",1.015689554,2.22e-16,0.099031288,-0.099031288,"neutral"]
["p.Leu300Cys",0.090575612,0.00055064,0.309291569,-0.309291569,"neutral"]
["p.Leu300Glu",0.838810116,0,-0.095839066,0.095839066,"neutral"]
["p.Leu300Gly",0.646142048,0,0.350949529,-0.350949529,"neutral"]
["p.Leu300Ser",0.572711124,1.28e-15,0.100779495,-0.100779495,"neutral"]
["p.Leu300Thr",0.075478618,2.27e-08,0.191314394,-0.191314394,"neutral"]
["p.Leu311Trp",1.04e-22,5.18e-44,-0.025106997,0.025106997,"neutral"]
["p.Leu311Tyr",0.556078058,0,-0.342790901,0.342790901,"neutral"]
["p.Leu325Asn",0.066997389,0.000195544,0.310717935,-0.310717935,"neutral"]
["p.Leu325Met",1.65e-29,2.65e-57,0.040892488,-0.040892488,"neutral"]
["p.Leu325Ser",4.18e-19,5.6e-37,-0.296207067,0.296207067,"neutral"]
["p.Leu349Cys",2.39e-15,1.19e-29,-0.26496298,0.26496298,"neutral"]
["p.Leu349Gly",5.34e-50,1.93e-97,-0.5913262,0.5913262,"neutral"]
["p.Leu349Met",0.216272744,3e-05,0.05540118,-0.05540118,"neutral"]
["p.Leu349Phe",1.84e-34,5.42e-67,0.06692562000000001,-0.06692562000000001,"neutral"]
["p.Leu349Ser",7.9e-05,9.320000000000001e-10,-0.1625491,0.1625491,"neutral"]
["p.Leu349Thr",0.150101071,0,-0.04476384,0.04476384,"neutral"]
["p.Leu349Trp",7.2e-11,5.6e-21,0.449793923,-0.449793923,"neutral"]
["p.Leu349Val",6.5e-25,2.58e-48,-0.432260827,0.432260827,"neutral"]
["p.Leu350Asn",1.07e-05,3.29e-11,-0.44401595,0.44401595,"neutral"]
["p.Leu350Gln",5.21e-25,1.72e-48,-0.11021957,0.11021957,"neutral"]
["p.Leu350Gly",5.41e-20,1.02e-38,-0.08206316299999999,0.08206316299999999,"neutral"]
["p.Leu350Ile",0.152017065,4.07e-10,-0.358309223,0.358309223,"neutral"]
["p.Leu350Met",4.81e-27,1.84e-52,-0.32753684,0.32753684,"neutral"]
["p.Leu353Ala",0.404904837,0,0.023945485,-0.023945485,"neutral"]
["p.Leu353Cys",3.36e-26,8.07e-51,-0.558771673,0.558771673,"neutral"]
["p.Leu353Ile",1.84e-09,2.63e-18,0.00686336,-0.00686336,"neutral"]
["p.Leu353Phe",0.016980406,1.64e-05,0.35903018,-0.35903018,"neutral"]
["p.Leu353Ser",0.00600865,6.57e-07,-0.07214134,0.07214134,"neutral"]
["p.Leu353Val",0.227161475,0,-0.287263165,0.287263165,"neutral"]
["p.Leu361Ala",1.87e-09,2.69e-18,-0.20358998,0.20358998,"neutral"]
["p.Leu361Arg",0.08965142,1.42e-07,0.216521215,-0.216521215,"neutral"]
["p.Leu361Glu",0.184764393,3.44e-13,0.118017261,-0.118017261,"neutral"]
["p.Leu361His",0.423406394,1.39e-16,0.259084018,-0.259084018,"neutral"]
["p.Leu361Ile",3.04e-20,3.46e-39,-0.592513749,0.592513749,"neutral"]
["p.Leu361Phe",1.53e-71,1.07e-139,-0.296028712,0.296028712,"neutral"]
["p.Leu361Ser",2.24e-18,1.49e-35,-0.346995057,0.346995057,"neutral"]
["p.Leu361Thr",5.29e-12,3.35e-23,-0.104935413,0.104935413,"neutral"]
["p.Leu361Tyr",6.07e-97,1.73e-189,-0.049365251,0.049365251,"neutral"]
["p.Leu363Ala",5.71e-07,1.44e-13,0.439838499,-0.439838499,"neutral"]
["p.Leu363Arg",4.47e-27,1.55e-52,0.282390453,-0.282390453,"neutral"]
["p.Leu366Met",1.03e-83,1.55e-163,-0.26742513,0.26742513,"neutral"]
["p.Leu366Val",0.010535972,7.689999999999999e-06,0.130499268,-0.130499268,"neutral"]
["p.Leu396Val",5.97e-13,5.16e-25,-0.508597308,0.508597308,"neutral"]
["p.Leu401Arg",0.293801776,0.00015477,-0.342538622,0.342538622,"neutral"]
["p.Leu401Gln",9.01e-13,1.1e-24,0.284029626,-0.284029626,"neutral"]
["p.Leu401Glu",0.327844918,2.78e-17,-0.156203338,0.156203338,"neutral"]
["p.Leu401Gly",1.86e-29,3.37e-57,-0.152310574,0.152310574,"neutral"]
["p.Leu401Ile",4.74e-13,3.31e-25,0.143268381,-0.143268381,"neutral"]
["p.Leu401Ser",0.218206831,0,0.336836734,-0.336836734,"neutral"]
["p.Leu401Val",0.117743732,7.77e-11,0.352783528,-0.352783528,"neutral"]
["p.Leu413Asn",0.519014661,2.95e-11,0.182285251,-0.182285251,"neutral"]
["p.Leu413Asp",0.908518311,3.33e-16,0.257647786,-0.257647786,"neutral"]
["p.Leu413Cys",3.17e-12,1.25e-23,-0.324626695,0.324626695,"neutral"]
["p.Leu413Gly",1.365351628,0,-0.334523876,0.334523876,"neutral"]
["p.Leu413His",0.429480177,0.000210753,-0.181391664,0.181391664,"neutral"]
["p.Leu413Ile",0.001112143,1.43e-08,0.280653631,-0.280653631,"neutral"]
["p.Leu413Met",6.89e-13,6.97e-25,-0.353635125,0.353635125,"neutral"]
["p.Leu413Phe",0.646445052,5.02e-09,-0.151413866,0.151413866,"neutral"]
["p.Leu413Ser",1.05e-15,2.46e-30,-0.566945504,0.566945504,"neutral"]
["p.Leu413Thr",0.582127287,0,0.299129005,-0.299129005,"neutral"]
["p.Leu413Tyr",2.36e-11,6.69e-22,-0.569656939,0.569656939,"neutral"]
["p.Leu413Val",0.227990693,0,0.052918462,-0.052918462,"neutral"]
["p.Leu438Ala",0.036957209,7.49e-05,0.176307371,-0.176307371,"neutral"]
["p.Leu438Asn",2.39e-56,7.109999999999999e-110,0.07741790699999999,-0.07741790699999999,"neutral"]
["p.Leu438Gly",0.284031119,0,0.234045052,-0.234045052,"neutral"]
["p.Leu438Met",0.214935536,6.94e-18,0.107322,-0.107322,"neutral"]
["p.Leu438Ser",1.58e-16,5.91e-32,0.143422721,-0.143422721,"neutral"]
["p.Leu438Val",4.22e-24,1.01e-46,0.404585881,-0.404585881,"neutral"]
["p.Leu454Cys",1.12e-27,1.02e-53,0.437345686,-0.437345686,"neutral"]
["p.Leu454Met",6.51e-57,5.3e-111,0.242360528,-0.242360528,"neutral"]
["p.Leu454Phe",4.07e-25,1.03e-48,-0.177804873,0.177804873,"neutral"]
["p.Leu454Tyr",6.29e-18,1.11e-34,0.439769126,-0.439769126,"neutral"]
["p.Leu454Val",9.570000000000001e-12,1.01e-22,0.427720533,-0.427720533,"neutral"]
["p.Leu455Ala",1.96e-36,7.399999999999999e-71,0.38899759,-0.38899759,"neutral"]
["p.Leu455Cys",1.27e-14,3.01e-28,0.275616372,-0.275616372,"neutral"]
["p.Leu455Ile",0.124796981,3.47e-18,0.091631002,-0.091631002,"neutral"]
["p.Leu455Phe",1.51e-74,1.43e-145,0.299496073,-0.299496073,"neutral"]
["p.Leu458Ala",0.213993856,3.36e-05,0.049433062,-0.049433062,"neutral"]
["p.Leu458Ile",0.146453669,1.03e-05,-0.296289194,0.296289194,"neutral"]
["p.Leu458Phe",1.98e-83,5.71e-163,-0.062674717,0.062674717,"neutral"]
["p.Leu458Ser",0.112788335,6.81e-09,0.4232516,-0.4232516,"neutral"]
["p.Leu458Val",1.32e-23,9.22e-46,0.408134844,-0.408134844,"neutral"]
["p.Leu475Ile",1.42e-70,9.2e-138,-0.404416031,0.404416031,"neutral"]
["p.Leu494Ala",4.5e-61,3.76e-119,0.051964076,-0.051964076,"neutral"]
["p.Leu494Met",7.78e-18,1.83e-34,-0.389038963,0.389038963,"neutral"]
["p.Leu494Trp",7.36e-20,2.01e-38,0.370448093,-0.370448093,"neutral"]
["p.Leu494Tyr",1.14e-49,8.49e-97,0.428217468,-0.428217468,"neutral"]
["p.Leu497Ala",0.22921854,0,0.290557828,-0.290557828,"neutral"]
["p.Leu497Phe",0.375757835,0.000316521,-0.566678964,0.566678964,"neutral"]
["p.Leu515Ala",1.32e-56,2.21e-110,0.160914993,-0.160914993,"neutral"]
["p.Leu515Asn",0.000636449,3.02e-08,0.321263949,-0.321263949,"neutral"]
["p.Leu515Cys",0.055468318,0.000199881,0.322626233,-0.322626233,"neutral"]
["p.Leu515Ile",8.26e-36,1.24e-69,0.162119153,-0.162119153,"neutral"]
["p.Leu515Met",4.1e-31,1.85e-60,0.21384727,-0.21384727,"neutral"]
["p.Leu515Phe",1.44e-08,1.32e-16,0.192801257,-0.192801257,"neutral"]
["p.Leu515Tyr",0.443240714,0,0.320998705,-0.320998705,"neutral"]
["p.Leu515Val",1.2e-28,1.29e-55,0.450947974,-0.450947974,"neutral"]
["p.Leu519Ala",0.49978118,0,0.204412259,-0.204412259,"neutral"]
["p.Leu519Gly",1.13e-30,1.42e-59,0.358891844,-0.358891844,"neutral"]
["p.Leu519Met",0.004677647,6.51e-07,-0.610450057,0.610450057,"neutral"]
["p.Leu519Phe",2.05e-08,2.32e-16,-0.002448807,0.002448807,"neutral"]
["p.Leu519Tyr",2.69e-13,1.13e-25,-0.450043385,0.450043385,"neutral"]
["p.Lys275Asn",6.56e-06,1.15e-11,-0.215419793,0.215419793,"neutral"]
["p.Lys275Asp",1.28e-30,1.86e-59,-0.456307,0.456307,"neutral"]
["p.Lys275Gln",2e-22,1.78e-43,-0.271513977,0.271513977,"neutral"]
["p.Lys275Leu",9.96e-16,2.12e-30,-0.562611038,0.562611038,"neutral"]
["p.Lys275Ser",0.001763182,8.940000000000001e-08,-0.44030568,0.44030568,"neutral"]
["p.Lys301Arg",8.01e-11,6.32e-21,0.379407743,-0.379407743,"neutral"]
["p.Lys301Val",1.31e-38,3.96e-75,0.381188418,-0.381188418,"neutral"]
["p.Lys318Met",4.35e-39,4.59e-76,0.430283107,-0.430283107,"neutral"]
["p.Lys319Ala",1.82e-44,1.4e-86,-0.339585744,0.339585744,"neutral"]
["p.Lys319Arg",0.202542439,0,-0.022842891,0.022842891,"neutral"]
["p.Lys319Asn",0.00115187,5.67e-08,-0.191305782,0.191305782,"neutral"]
["p.Lys319Asp",1.55e-05,5.59e-11,-0.588544678,0.588544678,"neutral"]
["p.Lys319Cys",1.49e-30,2.55e-59,-0.589484002,0.589484002,"neutral"]
["p.Lys319Gln",1.74e-05,7.39e-11,-0.100180448,0.100180448,"neutral"]
["p.Lys319Ile",2.76e-16,1.77e-31,-0.496893334,0.496893334,"neutral"]
["p.Lys319Leu",0.346769468,1.39e-17,-0.163115857,0.163115857,"neutral"]
["p.Lys319Met",0.267652061,2.16e-14,-0.462372544,0.462372544,"neutral"]
["p.Lys319Ser",0.236831959,2.08e-17,-0.124437768,0.124437768,"neutral"]
["p.Lys319Thr",0.005182849,4.92e-07,-0.391298884,0.391298884,"neutral"]
["p.Lys319Tyr",1.59e-38,5.95e-75,-0.292578555,0.292578555,"neutral"]
["p.Lys319Val",9.54e-33,1.25e-63,-0.377953334,0.377953334,"neutral"]
["p.Lys324Ala",0.75489348,2.22e-16,-0.53209367,0.53209367,"neutral"]
["p.Lys324Arg",1.72e-25,1.95e-49,-0.269615555,0.269615555,"neutral"]
["p.Lys324Cys",0.407482438,0,-0.221548374,0.221548374,"neutral"]
["p.Lys324Gln",1.72e-30,3.27e-59,-0.288692029,0.288692029,"neutral"]
["p.Lys324Gly",3.11e-48,5.2e-94,0.246080247,-0.246080247,"neutral"]
["p.Lys324His",0.320043168,2.62e-14,-0.480826286,0.480826286,"neutral"]
["p.Lys324Met",0.003117072,4.26e-07,0.07811380699999999,-0.07811380699999999,"neutral"]
["p.Lys324Ser",1.22e-12,2.11e-24,-0.158684641,0.158684641,"neutral"]
["p.Lys324Thr",7.44e-18,1.55e-34,-0.40608915,0.40608915,"neutral"]
["p.Lys324Tyr",0.286846826,0,0.009128000000000001,-0.009128000000000001,"neutral"]
["p.Lys346Ala",0.16953963,0,-0.151856162,0.151856162,"neutral"]
["p.Lys346Arg",1.56e-08,1.5e-16,-0.5811129390000001,0.5811129390000001,"neutral"]
["p.Lys346Asp",1.3e-52,1.42e-102,0.316902944,-0.316902944,"neutral"]
["p.Lys346Cys",5.03e-20,8.989999999999999e-39,0.068031076,-0.068031076,"neutral"]
["p.Lys346Gln",0.27135089,0,-0.011117835,0.011117835,"neutral"]
["p.Lys346Gly",0.623163146,0,0.299421352,-0.299421352,"neutral"]
["p.Lys346His",0.276812622,1.39e-17,0.278046779,-0.278046779,"neutral"]
["p.Lys346Ile",0.258468598,7.1e-13,-0.227353915,0.227353915,"neutral"]
["p.Lys346Leu",0.139791074,0,-0.159769249,0.159769249,"neutral"]
["p.Lys346Met",9.17e-11,8.549999999999999e-21,0.105122525,-0.105122525,"neutral"]
["p.Lys346Phe",0.230337465,6.94e-18,0.245127017,-0.245127017,"neutral"]
["p.Lys346Ser",0.296293909,0,-0.157920897,0.157920897,"neutral"]
["p.Lys346Thr",1.85e-13,5.79e-26,-0.170861464,0.170861464,"neutral"]
["p.Lys346Trp",0.320998643,6.819999999999999e-11,-0.224638252,0.224638252,"neutral"]
["p.Lys346Tyr",6.67e-06,1.47e-11,-0.237926071,0.237926071,"neutral"]
["p.Lys346Val",2.92e-31,1.01e-60,0.083265958,-0.083265958,"neutral"]
["p.Lys354Ala",1.47e-39,5.45e-77,0.293747202,-0.293747202,"neutral"]
["p.Lys354Asn",0.06336213,1.1e-07,-0.087510702,0.087510702,"neutral"]
["p.Lys354Asp",0.341228895,1.39e-17,0.005530195,-0.005530195,"neutral"]
["p.Lys354Cys",0.168031178,4.87e-09,-0.193769481,0.193769481,"neutral"]
["p.Lys354Gln",6.55e-51,3.1e-99,-0.164502291,0.164502291,"neutral"]
["p.Lys354Glu",0.166841095,1.04e-17,-0.244940233,0.244940233,"neutral"]
["p.Lys354Gly",1.25e-20,5.62e-40,0.004399697,-0.004399697,"neutral"]
["p.Lys354His",0.217060147,2.15e-16,-0.232010874,0.232010874,"neutral"]
["p.Lys354Ile",4.6e-36,3.94e-70,-0.228604668,0.228604668,"neutral"]
["p.Lys354Leu",2.22e-48,2.82e-94,0.08680802999999999,-0.08680802999999999,"neutral"]
["p.Lys354Met",1.02e-21,4.52e-42,-0.266300242,0.266300242,"neutral"]
["p.Lys354Phe",2.26e-12,7.27e-24,-0.232016304,0.232016304,"neutral"]
["p.Lys354Thr",2.54e-09,4.84e-18,-0.259521428,0.259521428,"neutral"]
["p.Lys354Trp",0.008598424,1.99e-06,-0.512144409,0.512144409,"neutral"]
["p.Lys354Tyr",0.07966448800000001,8.84e-06,-0.420813762,0.420813762,"neutral"]
["p.Lys354Val",8.89e-35,1.27e-67,-0.274073876,0.274073876,"neutral"]
["p.Lys359His",2.04e-72,2.17e-141,-0.229631647,0.229631647,"neutral"]
["p.Lys404Gln",0.361534376,2.57e-06,-0.395783753,0.395783753,"neutral"]
["p.Lys404Glu",1.1e-30,1.32e-59,0.399595036,-0.399595036,"neutral"]
["p.Lys404Ile",0.189001466,6.94e-18,0.10728488,-0.10728488,"neutral"]
["p.Lys404Leu",1.89e-77,2.96e-151,-0.030295552,0.030295552,"neutral"]
["p.Lys404Ser",2.5e-26,4.51e-51,-0.497553271,0.497553271,"neutral"]
["p.Lys404Tyr",0.292486288,4.45e-06,0.244160482,-0.244160482,"neutral"]
["p.Lys426Arg",0.000172775,3.1e-09,0.262676525,-0.262676525,"neutral"]
["p.Lys426Cys",4.12e-13,2.39e-25,-0.167077759,0.167077759,"neutral"]
["p.Lys426Met",1.52e-64,5.98e-126,-0.338013206,0.338013206,"neutral"]
["p.Lys426Phe",1.71e-13,4.84e-26,-0.599277319,0.599277319,"neutral"]
["p.Lys426Trp",6.91e-15,8.73e-29,0.156630557,-0.156630557,"neutral"]
["p.Lys430Met",4.32e-09,1.27e-17,0.328499414,-0.328499414,"neutral"]
["p.Lys445Arg",0.570121451,0,-0.219920123,0.219920123,"neutral"]
["p.Lys445Asp",4.61e-13,3.3e-25,-0.328508813,0.328508813,"neutral"]
["p.Lys445Cys",9.789999999999999e-05,1.41e-09,-0.027826684,0.027826684,"neutral"]
["p.Lys445Gln",7.15e-16,1.14e-30,-0.523585094,0.523585094,"neutral"]
["p.Lys445Glu",3.03e-121,4.01e-237,-0.171528804,0.171528804,"neutral"]
["p.Lys445His",5.94e-06,1.04e-11,-0.136432943,0.136432943,"neutral"]
["p.Lys445Leu",0.13235974,0,-0.085172214,0.085172214,"neutral"]
["p.Lys445Met",1.4e-14,3.64e-28,-0.066304799,0.066304799,"neutral"]
["p.Lys445Phe",1.21e-25,9.94e-50,-0.515084761,0.515084761,"neutral"]
["p.Lys445Pro",2.51e-11,6.74e-22,-0.275053904,0.275053904,"neutral"]
["p.Lys445Ser",1.24e-51,1.21e-100,-0.628169786,0.628169786,"neutral"]
["p.Lys445Trp",8.65e-43,2.55e-83,0.135872175,-0.135872175,"neutral"]
["p.Lys445Tyr",7.47e-121,2.34e-236,-0.619629812,0.619629812,"neutral"]
["p.Lys445Val",1.77e-74,1.94e-145,0.181275763,-0.181275763,"neutral"]
["p.Lys461Ala",0.219793985,8.1e-15,0.277158861,-0.277158861,"neutral"]
["p.Lys504Asn",8.39e-11,7.16e-21,-0.300057024,0.300057024,"neutral"]
["p.Lys504Asp",5.85e-20,1.21e-38,0.02559432,-0.02559432,"neutral"]
["p.Lys504Gly",1.59e-05,6.6e-11,-0.388933858,0.388933858,"neutral"]
["p.Lys504His",0.202125119,0,-0.20006423,0.20006423,"neutral"]
["p.Lys504Ser",0.242323725,0,-0.201848706,0.201848706,"neutral"]
["p.Lys504Thr",2.96e-69,3.45e-135,-0.474525165,0.474525165,"neutral"]
["p.Lys504Tyr",0.327130208,3.16e-15,0.199395999,-0.199395999,"neutral"]
["p.Lys504Val",0.249835536,1.97e-10,-0.112179608,0.112179608,"neutral"]
["p.Met286Ala",2.54e-22,3.06e-43,-0.128789544,0.128789544,"neutral"]
["p.Met286Asn",3.77e-10,1.18e-19,-0.026059954,0.026059954,"neutral"]
["p.Met286Cys",1.86e-94,1.28e-184,-0.102031917,0.102031917,"neutral"]
["p.Met286Gln",0.240814045,0,-0.210590776,0.210590776,"neutral"]
["p.Met286Glu",0.239202096,1.39e-17,-0.017702225,0.017702225,"neutral"]
["p.Met286His",1.05e-91,3.21e-179,-0.033243331,0.033243331,"neutral"]
["p.Met286Leu",1.62e-12,3.63e-24,-0.435018388,0.435018388,"neutral"]
["p.Met286Lys",1.9e-30,3.82e-59,0.042961277,-0.042961277,"neutral"]
["p.Met286Ser",5.32e-21,1.12e-40,-0.064946431,0.064946431,"neutral"]
["p.Met286Trp",0.030247578,6.65e-05,-0.594526216,0.594526216,"neutral"]
["p.Met344Lys",1.14e-28,1.19e-55,0.105362369,-0.105362369,"neutral"]
["p.Met344Phe",0.00333437,6.15e-08,0.341091191,-0.341091191,"neutral"]
["p.Met369Cys",1.02e-55,1.19e-108,0.073310576,-0.073310576,"neutral"]
["p.Met369Phe",0.43511406,2.78e-17,-7.93e-05,7.93e-05,"neutral"]
["p.Met369Thr",7.900000000000001e-08,3.2e-15,0.257106718,-0.257106718,"neutral"]
["p.Met369Val",4.98e-16,5.55e-31,0.117027035,-0.117027035,"neutral"]
["p.Met377Cys",0.003340529,2.08e-07,-0.551102697,0.551102697,"neutral"]
["p.Met377His",0.196427042,4.63e-10,0.258346698,-0.258346698,"neutral"]
["p.Met377Thr",7.449999999999999e-05,1e-09,-0.514294762,0.514294762,"neutral"]
["p.Met383Asn",1.64e-18,7.89e-36,0.183040011,-0.183040011,"neutral"]
["p.Met383Lys",0.38444345,3.66e-10,-0.060372866,0.060372866,"neutral"]
["p.Met469Arg",0.000489172,2.06e-08,0.327222657,-0.327222657,"neutral"]
["p.Met469Cys",1.23e-69,6.1e-136,0.313791073,-0.313791073,"neutral"]
["p.Met469Gln",1.22e-08,9.26e-17,0.277559839,-0.277559839,"neutral"]
["p.Met469Glu",1.63e-19,9.45e-38,0.406843639,-0.406843639,"neutral"]
["p.Met469Leu",0.096059436,2.42e-12,0.310314301,-0.310314301,"neutral"]
["p.Met469Phe",5.18e-49,1.69e-95,0.426030455,-0.426030455,"neutral"]
["p.Met469Tyr",0.070974776,1.23e-07,0.143522948,-0.143522948,"neutral"]
["p.Met484Gln",1.35e-08,1.15e-16,0.136089057,-0.136089057,"neutral"]
["p.Met484Glu",2.16e-24,2.63e-47,0.231430474,-0.231430474,"neutral"]
["p.Met484Ile",2.21e-20,1.77e-39,-0.09593515900000001,0.09593515900000001,"neutral"]
["p.Met484Leu",6.94e-19,1.4e-36,-0.186701436,0.186701436,"neutral"]
["p.Met484Pro",1.43e-94,7.729999999999999e-185,0.301539139,-0.301539139,"neutral"]
["p.Met498Gln",2.02e-10,3.78e-20,0.216518751,-0.216518751,"neutral"]
["p.Met498Glu",0.384140186,2.78e-17,-0.260357386,0.260357386,"neutral"]
["p.Met498His",0.641830468,1.11e-16,0.043386677,-0.043386677,"neutral"]
["p.Met498Ile",0.000155315,2.89e-09,0.188675038,-0.188675038,"neutral"]
["p.Met498Leu",7.32e-32,6.85e-62,0.425372071,-0.425372071,"neutral"]
["p.Met498Val",8.52e-11,6.94e-21,0.185857487,-0.185857487,"neutral"]
["p.Phe352Ala",0.004009977,6.14e-07,0.009354624000000001,-0.009354624000000001,"neutral"]
["p.Phe352Asn",7.12e-34,7.72e-66,0.389837704,-0.389837704,"neutral"]
["p.Phe352Cys",1.87e-51,2.72e-100,-0.164584847,0.164584847,"neutral"]
["p.Phe352His",1.98e-29,3.71e-57,0.066927759,-0.066927759,"neutral"]
["p.Phe352Ile",8.91e-29,7.14e-56,0.341394381,-0.341394381,"neutral"]
["p.Phe352Leu",7.32e-05,7.99e-10,0.169603004,-0.169603004,"neutral"]
["p.Phe352Met",0.207510507,1.39e-17,0.32201434,-0.32201434,"neutral"]
["p.Phe352Ser",8.44e-32,8.700000000000001e-62,0.315419229,-0.315419229,"neutral"]
["p.Phe352Thr",5.74e-31,3.71e-60,-0.183618446,0.183618446,"neutral"]
["p.Phe352Tyr",7.54e-44,2.13e-85,0.232932901,-0.232932901,"neutral"]
["p.Phe442Asn",3e-32,1.18e-62,-0.436363826,0.436363826,"neutral"]
["p.Phe442Cys",4.84e-42,7.45e-82,0.095774001,-0.095774001,"neutral"]
["p.Phe442Val",0.311849816,0,0.196275422,-0.196275422,"neutral"]
["p.Phe451Leu",0.000165049,2.77e-09,-0.101795249,0.101795249,"neutral"]
["p.Phe451Met",0.205067141,6.94e-18,0.155974309,-0.155974309,"neutral"]
["p.Phe451Trp",0.133252445,2.19e-05,0.427703301,-0.427703301,"neutral"]
["p.Phe512Asn",1.41e-27,1.65e-53,-0.166747919,0.166747919,"neutral"]
["p.Phe512Cys",5.41e-23,1.46e-44,0.09008709199999999,-0.09008709199999999,"neutral"]
["p.Phe512His",1.05e-41,3.56e-81,-0.253983315,0.253983315,"neutral"]
["p.Phe512Leu",2.18e-33,6.83e-65,-0.467014443,0.467014443,"neutral"]
["p.Phe512Ser",0.118923752,4.87e-15,0.090061603,-0.090061603,"neutral"]
["p.Phe512Tyr",2.12e-20,1.65e-39,-0.112516179,0.112516179,"neutral"]
["p.Phe518Asp",0.568593964,2.09e-14,0.23752121,-0.23752121,"neutral"]
["p.Phe518Ile",0.306187014,0,0.002169271,-0.002169271,"neutral"]
["p.Phe518Leu",6.61e-26,2.92e-50,0.101682725,-0.101682725,"neutral"]
["p.Phe518Thr",2.91e-25,5.54e-49,0.383853278,-0.383853278,"neutral"]
["p.Phe518Trp",3.41e-38,2.63e-74,0.410636441,-0.410636441,"neutral"]
["p.Phe518Tyr",1.73e-25,2.02e-49,-0.10938229,0.10938229,"neutral"]
["p.Pro302Ala",1.51e-16,5.23e-32,-0.076694044,0.076694044,"neutral"]
["p.Pro302Arg",0.009453922999999999,5.1e-06,0.335445376,-0.335445376,"neutral"]
["p.Pro302Asn",2.68e-21,3.09e-41,-0.497696949,0.497696949,"neutral"]
["p.Pro302Glu",5.19e-76,1.95e-148,-0.581491189,0.581491189,"neutral"]
["p.Pro302Gly",0.503700587,1.11e-16,-0.076996603,0.076996603,"neutral"]
["p.Pro302Ile",0.10455455,0.000365054,0.09553057,-0.09553057,"neutral"]
["p.Pro302Leu",0.267515805,3.61e-16,-0.174111021,0.174111021,"neutral"]
["p.Pro302Lys",1.15e-08,8.77e-17,-0.312997126,0.312997126,"neutral"]
["p.Pro302Met",5.77e-41,9.719999999999999e-80,0.375042535,-0.375042535,"neutral"]
["p.Pro302Ser",3.45e-34,1.81e-66,-0.223048121,0.223048121,"neutral"]
["p.Pro302Thr",6.59e-25,2.56e-48,-0.167443407,0.167443407,"neutral"]
["p.Pro302Val",5.19e-30,2.75e-58,0.127268792,-0.127268792,"neutral"]
["p.Pro307Ala",3.77e-29,1.36e-56,-0.553219744,0.553219744,"neutral"]
["p.Pro307Arg",9.680000000000001e-07,3.27e-13,-0.273570049,0.273570049,"neutral"]
["p.Pro307Cys",0.00022398,6.22e-09,-0.406003582,0.406003582,"neutral"]
["p.Pro307Gly",0.019063331,5.61e-06,0.226794304,-0.226794304,"neutral"]
["p.Pro307Ile",7.35e-48,3.11e-93,0.442667213,-0.442667213,"neutral"]
["p.Pro307Lys",1.11e-13,2.1e-26,-0.061018717,0.061018717,"neutral"]
["p.Pro307Met",1.26e-55,1.78e-108,-0.009255793999999999,0.009255793999999999,"neutral"]
["p.Pro307Phe",2.95e-07,4.02e-14,-0.060411721,0.060411721,"neutral"]
["p.Pro307Thr",1.25e-78,1.41e-153,-0.498902426,0.498902426,"neutral"]
["p.Pro307Tyr",2.73e-06,2.66e-12,-0.278597555,0.278597555,"neutral"]
["p.Pro307Val",0.174503101,6.16e-10,0.379886965,-0.379886965,"neutral"]
["p.Pro364Ala",1.52e-10,2.3e-20,0.446174679,-0.446174679,"neutral"]
["p.Pro364Arg",0.2129264,3.24e-09,0.34788527,-0.34788527,"neutral"]
["p.Pro364Gly",6.94e-06,1.34e-11,0.260141797,-0.260141797,"neutral"]
["p.Pro364Leu",9.77e-05,1.55e-09,0.460013383,-0.460013383,"neutral"]
["p.Pro364Lys",7.779999999999999e-05,1.1e-09,0.107251757,-0.107251757,"neutral"]
["p.Pro364Ser",1.18e-07,7.09e-15,0.430585391,-0.430585391,"neutral"]
["p.Pro364Thr",0.02527001,3.97e-05,0.426343694,-0.426343694,"neutral"]
["p.Pro364Tyr",4.89e-08,1.38e-15,0.453906052,-0.453906052,"neutral"]
["p.Pro434Ala",0.08640561300000001,2.5e-05,-0.062983941,0.062983941,"neutral"]
["p.Pro434Arg",0.029827158,6.08e-05,0.107533315,-0.107533315,"neutral"]
["p.Pro434Glu",1.38e-20,7.12e-40,0.123741257,-0.123741257,"neutral"]
["p.Pro434Gly",0.298605527,1.39e-17,-0.096285619,0.096285619,"neutral"]
["p.Pro434His",0.324176275,0,0.329094477,-0.329094477,"neutral"]
["p.Pro434Leu",6.839999999999999e-36,8.25e-70,0.133275533,-0.133275533,"neutral"]
["p.Pro434Phe",4.39e-14,3.29e-27,-0.107793014,0.107793014,"neutral"]
["p.Pro434Ser",4.06e-06,4.88e-12,-0.117923989,0.117923989,"neutral"]
["p.Pro434Tyr",1.1e-38,2.94e-75,0.08257118500000001,-0.08257118500000001,"neutral"]
["p.Pro434Val",3.81e-32,1.95e-62,-0.021545204,0.021545204,"neutral"]
["p.Pro465Val",0.019800219,4.21e-16,-0.130057781,0.130057781,"neutral"]
["p.Pro467Ala",0.261408725,1.39e-17,0.080655832,-0.080655832,"neutral"]
["p.Pro467Cys",8.6e-14,1.17e-26,0.17555396,-0.17555396,"neutral"]
["p.Pro467Gly",6.71e-31,4.91e-60,0.364891698,-0.364891698,"neutral"]
["p.Pro467His",8.3e-32,8.590000000000001e-62,0.354896928,-0.354896928,"neutral"]
["p.Pro467Leu",5.36e-21,1.16e-40,0.377242534,-0.377242534,"neutral"]
["p.Pro467Met",0.137185072,2.71e-16,0.278574987,-0.278574987,"neutral"]
["p.Pro467Phe",1.39e-25,1.26e-49,0.296390872,-0.296390872,"neutral"]
["p.Pro467Tyr",1.320113212,2.22e-15,-0.5606535540000001,0.5606535540000001,"neutral"]
["p.Pro467Val",1.48e-15,4.45e-30,0.202552791,-0.202552791,"neutral"]
["p.Pro485Ala",0.000753286,2.11e-08,0.193634385,-0.193634385,"neutral"]
["p.Pro485Arg",0.016081154,1.03e-06,-0.056789808,0.056789808,"neutral"]
["p.Pro485Asn",3.46e-17,2.99e-33,0.244396271,-0.244396271,"neutral"]
["p.Pro485Asp",2.61e-45,3.05e-88,0.126572527,-0.126572527,"neutral"]
["p.Pro485Cys",4.68e-07,8.539999999999999e-14,0.368276461,-0.368276461,"neutral"]
["p.Pro485Gln",0.169902618,0,0.073903048,-0.073903048,"neutral"]
["p.Pro485Glu",5.72e-11,3.14e-21,0.246320925,-0.246320925,"neutral"]
["p.Pro485Gly",0.13523134,2.49e-15,0.189926389,-0.189926389,"neutral"]
["p.Pro485His",7.36e-35,9.190000000000001e-68,0.36471904,-0.36471904,"neutral"]
["p.Pro485Ile",0.085960387,1.55e-06,0.453175232,-0.453175232,"neutral"]
["p.Pro485Leu",1.31e-36,3.39e-71,0.309671183,-0.309671183,"neutral"]
["p.Pro485Lys",2.79e-65,2.15e-127,0.238924249,-0.238924249,"neutral"]
["p.Pro485Met",6.37e-18,1.11e-34,0.251999561,-0.251999561,"neutral"]
["p.Pro485Ser",5.96e-42,1.11e-81,0.194546977,-0.194546977,"neutral"]
["p.Pro485Thr",8.32e-49,4.13e-95,0.262163449,-0.262163449,"neutral"]
["p.Pro485Tyr",0.21033365,2.08e-17,0.403372615,-0.403372615,"neutral"]
["p.Pro485Val",4.57e-19,6.69e-37,0.316456596,-0.316456596,"neutral"]
["p.Pro487Ala",5.14e-57,3.39e-111,0.405352574,-0.405352574,"neutral"]
["p.Pro487Glu",0.09356771,0.00025741,0.054349099,-0.054349099,"neutral"]
["p.Pro487Ile",0.11423193,6.92e-05,-0.123283436,0.123283436,"neutral"]
["p.Pro487Leu",3.05e-50,6.320000000000001e-98,0.379032444,-0.379032444,"neutral"]
["p.Pro487Ser",4.78e-87,4.39e-170,0.411700864,-0.411700864,"neutral"]
["p.Pro487Tyr",1.11e-11,1.49e-22,0.23136334,-0.23136334,"neutral"]
["p.Pro487Val",0.188503469,6.94e-18,-0.036031922,0.036031922,"neutral"]
["p.Pro488Ala",4.53e-45,9.04e-88,-0.205492721,0.205492721,"neutral"]
["p.Pro488Arg",4.84e-05,3.91e-10,-0.274592707,0.274592707,"neutral"]
["p.Pro488Asp",1.53e-10,2.19e-20,0.146881441,-0.146881441,"neutral"]
["p.Pro488His",1.03e-31,1.34e-61,-0.245518055,0.245518055,"neutral"]
["p.Pro488Lys",0.133270417,6.38e-11,0.269656237,-0.269656237,"neutral"]
["p.Pro488Met",0.179042561,1.97e-11,-0.209766277,0.209766277,"neutral"]
["p.Pro488Ser",3.76e-37,2.87e-72,-0.427115659,0.427115659,"neutral"]
["p.Pro488Thr",1.58e-64,6.19e-126,-0.07338688,0.07338688,"neutral"]
["p.Pro488Val",1.64e-33,3.83e-65,-0.1413502,0.1413502,"neutral"]
["p.Pro491Ala",3.7e-05,2.85e-10,0.321390751,-0.321390751,"neutral"]
["p.Pro491Arg",1.49e-28,1.96e-55,0.399615208,-0.399615208,"neutral"]
["p.Pro491Cys",1.72e-48,1.7e-94,0.145464736,-0.145464736,"neutral"]
["p.Pro491Ile",5.620000000000001e-32,3.99e-62,0.394678366,-0.394678366,"neutral"]
["p.Pro491Lys",2.4e-29,5.5e-57,0.362516972,-0.362516972,"neutral"]
["p.Pro491Met",5.35e-29,2.67e-56,0.231417549,-0.231417549,"neutral"]
["p.Pro491Tyr",2.27e-16,1.19e-31,0.288166579,-0.288166579,"neutral"]
["p.Pro506Ala",1.82e-33,4.45e-65,0.064076932,-0.064076932,"neutral"]
["p.Pro506Asp",0.200048045,0,-0.09762027600000001,0.09762027600000001,"neutral"]
["p.Pro506Cys",0.157255338,1.02e-13,-0.200714335,0.200714335,"neutral"]
["p.Pro506Glu",1.2e-21,6.08e-42,-0.139337305,0.139337305,"neutral"]
["p.Pro506Gly",0.097871966,5.98e-09,-0.294216931,0.294216931,"neutral"]
["p.Pro506Leu",2.3e-10,5.02e-20,-0.292636639,0.292636639,"neutral"]
["p.Pro506Met",5.19e-89,6.45e-174,-0.545173333,0.545173333,"neutral"]
["p.Pro506Ser",3.58e-12,1.56e-23,-0.225067545,0.225067545,"neutral"]
["p.Pro506Thr",3.65e-31,1.52e-60,-0.319806405,0.319806405,"neutral"]
["p.Pro506Val",8.06e-10,5.24e-19,-0.404489367,0.404489367,"neutral"]
["p.Pro510Gln",4.22e-73,9.98e-143,0.402890155,-0.402890155,"neutral"]
["p.Pro510Glu",3.96e-37,3.28e-72,0.251151134,-0.251151134,"neutral"]
["p.Pro510Gly",0.283647807,1.39e-17,0.045261329,-0.045261329,"neutral"]
["p.Pro510Ile",0.226932116,0.000521731,-0.405065158,0.405065158,"neutral"]
["p.Pro510Lys",0.135481046,1.24e-09,0.41656182,-0.41656182,"neutral"]
["p.Ser306Ala",1.85e-70,1.56e-137,0.448881323,-0.448881323,"neutral"]
["p.Ser306Gly",1.5e-05,5.41e-11,-0.03346797,0.03346797,"neutral"]
["p.Ser306Pro",1.82e-33,4.93e-65,0.448128965,-0.448128965,"neutral"]
["p.Ser333Glu",2.09e-19,1.44e-37,0.020750405,-0.020750405,"neutral"]
["p.Ser333His",4.69e-46,1.06e-89,-0.370696553,0.370696553,"neutral"]
["p.Ser333Tyr",1.64e-13,4.15e-26,0.054731463,-0.054731463,"neutral"]
["p.Ser345Asn",0.007339414,8.99e-07,0.006791038,-0.006791038,"neutral"]
["p.Ser345Asp",3.61e-37,2.84e-72,-0.533897398,0.533897398,"neutral"]
["p.Ser345Cys",3.83e-11,1.57e-21,-0.301781432,0.301781432,"neutral"]
["p.Ser345Gly",0.101964908,1.16e-05,-0.04241427,0.04241427,"neutral"]
["p.Ser345His",0.079963224,4.76e-09,-0.081480859,0.081480859,"neutral"]
["p.Ser345Ile",7.32e-16,1.15e-30,-0.414328929,0.414328929,"neutral"]
["p.Ser345Met",0.000120978,2.94e-09,-0.555060131,0.555060131,"neutral"]
["p.Ser345Pro",2.68e-58,1.07e-113,-0.359811402,0.359811402,"neutral"]
["p.Ser345Thr",0.378006532,2.22e-16,0.160542767,-0.160542767,"neutral"]
["p.Ser345Tyr",0.438962746,0,-0.2053453,0.2053453,"neutral"]
["p.Ser345Val",6.24e-22,1.67e-42,-0.237327837,0.237327837,"neutral"]
["p.Ser348Cys",0.266618434,2.78e-17,0.134604036,-0.134604036,"neutral"]
["p.Ser375Ala",0.309864105,2.78e-17,0.138529611,-0.138529611,"neutral"]
["p.Ser375Gln",1.63e-46,1.28e-90,0.082250554,-0.082250554,"neutral"]
["p.Ser375Glu",3.05e-40,2.43e-78,0.08044194,-0.08044194,"neutral"]
["p.Ser375Gly",1.79e-69,1.25e-135,-0.03904915,0.03904915,"neutral"]
["p.Ser375Leu",2.54e-61,1.24e-119,-0.449811763,0.449811763,"neutral"]
["p.Ser375Met",1.31e-08,1.1e-16,-0.154212119,0.154212119,"neutral"]
["p.Ser375Thr",4.66e-28,1.81e-54,-0.00662606,0.00662606,"neutral"]
["p.Ser375Trp",3.67e-05,2.7e-10,-0.018752556,0.018752556,"neutral"]
["p.Ser375Val",7.48e-36,1.01e-69,0.157693915,-0.157693915,"neutral"]
["p.Ser450Thr",4.43e-14,3.29e-27,0.459170136,-0.459170136,"neutral"]
["p.Thr288Ala",9.92e-76,7.34e-148,-0.214037665,0.214037665,"neutral"]
["p.Thr288Arg",4.3e-13,2.7e-25,-0.329213594,0.329213594,"neutral"]
["p.Thr288Asn",0.20751098,0,0.392970002,-0.392970002,"neutral"]
["p.Thr288Asp",0.293258399,0,-0.268043066,0.268043066,"neutral"]
["p.Thr288Cys",4.84e-112,4.22e-219,-0.347260777,0.347260777,"neutral"]
["p.Thr288Gln",1.34e-46,8.98e-91,-0.427614424,0.427614424,"neutral"]
["p.Thr288Glu",0.163539455,4.55e-10,-0.476046009,0.476046009,"neutral"]
["p.Thr288Gly",1.63e-42,9.01e-83,-0.368038901,0.368038901,"neutral"]
["p.Thr288His",3.02e-35,1.57e-68,-0.088677594,0.088677594,"neutral"]
["p.Thr288Ile",0.006743072,6.4e-07,-0.291234991,0.291234991,"neutral"]
["p.Thr288Leu",8.36e-24,3.83e-46,-0.290623679,0.290623679,"neutral"]
["p.Thr288Lys",0.149804983,1.73e-08,-0.07903418800000001,0.07903418800000001,"neutral"]
["p.Thr288Met",0.197677085,1.02e-12,-0.345470513,0.345470513,"neutral"]
["p.Thr288Phe",9.87e-104,8.36e-203,-0.09479362400000001,0.09479362400000001,"neutral"]
["p.Thr288Pro",2.15e-39,1.16e-76,-0.094435371,0.094435371,"neutral"]
["p.Thr288Ser",0.000326394,5.06e-09,0.151440015,-0.151440015,"neutral"]
["p.Thr288Trp",0.252569736,0,-0.298280723,0.298280723,"neutral"]
["p.Thr288Tyr",0.35350967,6.94e-17,0.001048931,-0.001048931,"neutral"]
["p.Thr288Val",2.02e-32,5.29e-63,-0.420081019,0.420081019,"neutral"]
["p.Thr292Ala",9.22e-78,7.1e-152,0.12524133,-0.12524133,"neutral"]
["p.Thr292Cys",3.27e-09,7.67e-18,0.164246804,-0.164246804,"neutral"]
["p.Thr292Gln",2.09e-09,3.1e-18,-0.235585799,0.235585799,"neutral"]
["p.Thr292Glu",1.74e-46,1.51e-90,-0.346554068,0.346554068,"neutral"]
["p.Thr292Gly",0.002020157,8.79e-08,-0.292321264,0.292321264,"neutral"]
["p.Thr292His",1.19e-07,7.2e-15,-0.502664353,0.502664353,"neutral"]
["p.Thr292Ile",0.134641492,2.5e-07,-0.323890174,0.323890174,"neutral"]
["p.Thr292Leu",0.092044932,0.000528694,-0.552838189,0.552838189,"neutral"]
["p.Thr292Met",0.313265818,0,-0.569436378,0.569436378,"neutral"]
["p.Thr292Phe",1.37e-21,8.1e-42,-0.08814388500000001,0.08814388500000001,"neutral"]
["p.Thr292Pro",2.07e-07,2.21e-14,-0.48157127,0.48157127,"neutral"]
["p.Thr292Ser",0.387327403,0,0.145924221,-0.145924221,"neutral"]
["p.Thr293Ala",9.150000000000001e-15,1.57e-28,0.291140611,-0.291140611,"neutral"]
["p.Thr293Asn",4.46e-08,1.24e-15,-0.437196715,0.437196715,"neutral"]
["p.Thr293Cys",0.216007274,1.39e-17,0.335883603,-0.335883603,"neutral"]
["p.Thr293Gln",2.77e-14,1.25e-27,-0.03314824,0.03314824,"neutral"]
["p.Thr293Glu",0.169004823,1.39e-17,-0.103723701,0.103723701,"neutral"]
["p.Thr293His",1.58e-21,1.06e-41,-0.359698782,0.359698782,"neutral"]
["p.Thr293Ile",0.140678208,1.73e-17,-0.405388006,0.405388006,"neutral"]
["p.Thr293Met",0.214010467,0,0.218590481,-0.218590481,"neutral"]
["p.Thr293Pro",4.94e-06,6.83e-12,0.06464671499999999,-0.06464671499999999,"neutral"]
["p.Thr293Ser",4.42e-30,2.08e-58,-0.565788854,0.565788854,"neutral"]
["p.Thr293Tyr",0.182311257,4.03e-10,-0.071370135,0.071370135,"neutral"]
["p.Thr299Arg",9.57e-05,1.14e-09,-0.124340167,0.124340167,"neutral"]
["p.Thr299Asn",6.92e-40,1.25e-77,0.397374696,-0.397374696,"neutral"]
["p.Thr299Gly",0.001015505,3.3e-08,-0.463092027,0.463092027,"neutral"]
["p.Thr299His",2.71e-26,5.31e-51,-0.255851283,0.255851283,"neutral"]
["p.Thr299Trp",1.44e-25,1.32e-49,0.269882941,-0.269882941,"neutral"]
["p.Thr304Ala",0.348470539,2.78e-17,-0.348156337,0.348156337,"neutral"]
["p.Thr304Asp",1.11e-36,2.38e-71,0.45487659,-0.45487659,"neutral"]
["p.Thr304Glu",4.7e-15,4.24e-29,0.119897572,-0.119897572,"neutral"]
["p.Thr304Gly",0.367154279,8.189999999999999e-15,-0.058350119,0.058350119,"neutral"]
["p.Thr304His",0.142671551,3.47e-18,-0.167349177,0.167349177,"neutral"]
["p.Thr304Met",1.18e-20,5.36e-40,-0.043071514,0.043071514,"neutral"]
["p.Thr304Pro",0.030003992,3.36e-05,-0.075304199,0.075304199,"neutral"]
["p.Thr304Ser",0.118524494,0,-0.087579824,0.087579824,"neutral"]
["p.Thr304Trp",0.17370174,2.6e-05,0.033341431,-0.033341431,"neutral"]
["p.Thr304Tyr",0.396501478,0,-0.060886956,0.060886956,"neutral"]
["p.Thr357Ala",4.03e-07,6.34e-14,-0.476806273,0.476806273,"neutral"]
["p.Thr357Arg",1.01e-15,2.13e-30,-0.108335727,0.108335727,"neutral"]
["p.Thr357Asn",9.16e-32,9.969999999999999e-62,-0.15526569,0.15526569,"neutral"]
["p.Thr357Cys",0.115423494,1.04e-09,-0.335543667,0.335543667,"neutral"]
["p.Thr357Gln",0.003078595,4.24e-08,0.09074644699999999,-0.09074644699999999,"neutral"]
["p.Thr357Glu",4.99e-48,1.4e-93,-0.02230553,0.02230553,"neutral"]
["p.Thr357Gly",7.02e-05,6.18e-10,-0.08151462900000001,0.08151462900000001,"neutral"]
["p.Thr357His",0.074837023,5.43e-05,-0.366100731,0.366100731,"neutral"]
["p.Thr357Ile",6.85e-07,1.78e-13,-0.167610803,0.167610803,"neutral"]
["p.Thr357Leu",0.306270282,0,0.049718485,-0.049718485,"neutral"]
["p.Thr357Lys",0.189736314,1.6e-16,-0.186366862,0.186366862,"neutral"]
["p.Thr357Met",4.56e-23,1.07e-44,-0.38614254,0.38614254,"neutral"]
["p.Thr357Phe",0.12394764,2.24e-14,-0.245147363,0.245147363,"neutral"]
["p.Thr357Pro",6.59e-13,6.18e-25,-0.332378918,0.332378918,"neutral"]
["p.Thr357Tyr",1.5e-28,2.02e-55,-0.500432338,0.500432338,"neutral"]
["p.Thr357Val",0.303520412,4.16e-17,-0.02886511,0.02886511,"neutral"]
["p.Thr420Asn",0.217744601,0,0.114996793,-0.114996793,"neutral"]
["p.Thr420Cys",0.420732235,0,0.443290946,-0.443290946,"neutral"]
["p.Thr420Gln",0.118363028,2.32e-09,-0.478288032,0.478288032,"neutral"]
["p.Thr420Met",5.41e-49,1.77e-95,-0.302687581,0.302687581,"neutral"]
["p.Thr420Phe",0.197782065,2.08e-17,-0.393576979,0.393576979,"neutral"]
["p.Thr420Tyr",3.53e-23,6.5e-45,-0.28877328,0.28877328,"neutral"]
["p.Thr443Ala",6.31e-14,6.23e-27,-0.063788211,0.063788211,"neutral"]
["p.Thr443Asn",9.97e-18,2.74e-34,-0.392369631,0.392369631,"neutral"]
["p.Thr443Cys",1.08e-23,6.41e-46,-0.406059104,0.406059104,"neutral"]
["p.Thr443Gly",0.422938519,8.330000000000001e-17,0.081343255,-0.081343255,"neutral"]
["p.Thr443His",1.26e-99,1e-194,-0.548807002,0.548807002,"neutral"]
["p.Thr443Lys",0.157328092,1.73e-17,-0.613219645,0.613219645,"neutral"]
["p.Thr443Ser",4.86e-08,1.21e-15,-0.291057986,0.291057986,"neutral"]
["p.Thr456Ala",1.34e-32,2.36e-63,0.450715659,-0.450715659,"neutral"]
["p.Thr456Asn",1.17e-20,5.17e-40,-0.134733145,0.134733145,"neutral"]
["p.Thr456Asp",6.1e-21,1.48e-40,0.337040122,-0.337040122,"neutral"]
["p.Thr456Cys",3.26e-53,9.64e-104,0.353791406,-0.353791406,"neutral"]
["p.Thr456Gln",0.216863422,2.98e-16,0.133201167,-0.133201167,"neutral"]
["p.Thr456His",0.634800526,0,0.307031973,-0.307031973,"neutral"]
["p.Thr456Ile",1.51e-40,6.090000000000001e-79,0.090349729,-0.090349729,"neutral"]
["p.Thr456Met",1.71e-11,3.16e-22,-0.056760059,0.056760059,"neutral"]
["p.Thr456Val",9.419999999999999e-16,1.77e-30,0.008422605999999999,-0.008422605999999999,"neutral"]
["p.Thr459Ala",0.219556955,0,-0.101620614,0.101620614,"neutral"]
["p.Thr459Cys",1.93e-11,4.55e-22,-0.504149001,0.504149001,"neutral"]
["p.Thr460Ala",1.04e-29,1.08e-57,0.133894527,-0.133894527,"neutral"]
["p.Thr460Asn",6.94e-08,2.75e-15,0.028974462,-0.028974462,"neutral"]
["p.Thr460Gln",6.59e-31,4.94e-60,0.252562101,-0.252562101,"neutral"]
["p.Thr460Glu",7.06e-19,1.52e-36,0.393219481,-0.393219481,"neutral"]
["p.Thr460Gly",5.43e-54,2.91e-105,-0.134010994,0.134010994,"neutral"]
["p.Thr460Leu",0.241285539,0,-0.089945516,0.089945516,"neutral"]
["p.Thr460Met",1.47e-63,4.93e-124,0.328028448,-0.328028448,"neutral"]
["p.Thr460Phe",0.5613936899999999,1.11e-16,-0.09750326500000001,0.09750326500000001,"neutral"]
["p.Thr460Ser",0.157092671,6.77e-07,0.181997187,-0.181997187,"neutral"]
["p.Thr511Ala",4.88e-08,1.44e-15,-0.265970936,0.265970936,"neutral"]
["p.Thr511Arg",0.166461689,1.39e-17,-0.239209384,0.239209384,"neutral"]
["p.Thr511Cys",1.29e-12,2.57e-24,0.049357862,-0.049357862,"neutral"]
["p.Thr511Ser",9.65e-26,6.16e-50,-0.244430753,0.244430753,"neutral"]
["p.Trp289Ala",2.31e-47,2.89e-92,-0.220290159,0.220290159,"neutral"]
["p.Trp289Gly",0.306285249,3.17e-07,-0.444607733,0.444607733,"neutral"]
["p.Trp289Leu",4.77e-28,1.99e-54,-0.339601266,0.339601266,"neutral"]
["p.Trp289Met",1.5e-05,6.62e-11,-0.493769423,0.493769423,"neutral"]
["p.Trp289Phe",0.047792982,4.34e-19,0.09153476000000001,-0.09153476000000001,"neutral"]
["p.Trp289Pro",5e-38,5.54e-74,0.138279768,-0.138279768,"neutral"]
["p.Trp289Ser",7.27e-14,8.97e-27,0.073980829,-0.073980829,"neutral"]
["p.Trp289Tyr",1.1e-44,5.07e-87,-0.360262227,0.360262227,"neutral"]
["p.Trp449Phe",1.79e-24,1.81e-47,-0.08661775100000001,0.08661775100000001,"neutral"]
["p.Trp449Tyr",0.5174606309999999,0,0.169003374,-0.169003374,"neutral"]
["p.Trp502Asn",5.16e-77,2.18e-150,0.094450168,-0.094450168,"neutral"]
["p.Trp502Cys",2.4e-39,1.49e-76,0.360688803,-0.360688803,"neutral"]
["p.Trp502Gln",5.04e-18,7.38e-35,0.164967008,-0.164967008,"neutral"]
["p.Trp502Glu",3.69e-18,3.72e-35,-0.023433818,0.023433818,"neutral"]
["p.Trp502Ser",0.143428064,5.57e-08,0.380334663,-0.380334663,"neutral"]
["p.Trp502Thr",5.96e-65,9.28e-127,0.293493293,-0.293493293,"neutral"]
["p.Tyr329Ala",1.37e-21,7.75e-42,-0.286369396,0.286369396,"neutral"]
["p.Tyr329Asn",0.242782893,1.39e-17,-0.115363756,0.115363756,"neutral"]
["p.Tyr329Cys",0.125583017,5.27e-05,-0.172684907,0.172684907,"neutral"]
["p.Tyr329Glu",1.08e-15,2.52e-30,-0.419353767,0.419353767,"neutral"]
["p.Tyr329Gly",0,0,-0.198881759,0.198881759,"neutral"]
["p.Tyr329His",3.87e-37,3.08e-72,-0.226656535,0.226656535,"neutral"]
["p.Tyr329Leu",9.619999999999999e-41,2.71e-79,-0.57332111,0.57332111,"neutral"]
["p.Tyr329Met",2.58e-07,2.82e-14,-0.305788252,0.305788252,"neutral"]
["p.Tyr329Phe",3.98e-13,2.34e-25,-0.232689781,0.232689781,"neutral"]
["p.Tyr329Ser",2.78e-12,1.06e-23,0.241579684,-0.241579684,"neutral"]
["p.Tyr329Thr",0.739496862,0,-0.425615533,0.425615533,"neutral"]
["p.Tyr329Trp",0.621752596,1.67e-16,0.017146953,-0.017146953,"neutral"]
["p.Tyr329Val",7.99e-07,2.88e-13,-0.605543638,0.605543638,"neutral"]
["p.Tyr338Glu",0.175348741,0,0.40479018,-0.40479018,"neutral"]
["p.Tyr338His",1.43e-59,3.44e-116,0.097390715,-0.097390715,"neutral"]
["p.Tyr338Met",4.63e-27,1.7e-52,0.167107224,-0.167107224,"neutral"]
["p.Tyr338Phe",0.212032613,7.54e-07,-0.375185147,0.375185147,"neutral"]
["p.Tyr343Asn",0.00048649,2.65e-08,-0.450639909,0.450639909,"neutral"]
["p.Tyr360Ala",5.95e-20,1.26e-38,0.300717209,-0.300717209,"neutral"]
["p.Tyr360Asp",0.948610716,5.55e-16,-0.234145562,0.234145562,"neutral"]
["p.Tyr360Gly",1.39e-47,1.05e-92,0.252657244,-0.252657244,"neutral"]
["p.Tyr360Ile",3.91e-56,1.85e-109,0.414133293,-0.414133293,"neutral"]
["p.Tyr360Met",3.04e-14,1.58e-27,0.053891122,-0.053891122,"neutral"]
["p.Tyr360Val",5.89e-23,1.72e-44,0.278622758,-0.278622758,"neutral"]
["p.Tyr379His",0.360832551,0,0.109913418,-0.109913418,"neutral"]
["p.Tyr379Lys",0.56648791,0,0.22520067,-0.22520067,"neutral"]
["p.Tyr379Phe",6.81e-18,1.3e-34,0.355389263,-0.355389263,"neutral"]
["p.Tyr379Trp",0.384707434,0,-0.186475427,0.186475427,"neutral"]
["p.Tyr385Ala",0.492877786,1.11e-16,-0.39802271,0.39802271,"neutral"]
["p.Tyr385Cys",4.65e-20,7.819999999999999e-39,-0.451350287,0.451350287,"neutral"]
["p.Tyr385Met",2.31e-20,1.97e-39,0.217406508,-0.217406508,"neutral"]
["p.Tyr385Thr",1.03e-108,1.51e-212,-0.287294005,0.287294005,"neutral"]
["p.Tyr439Arg",2.55e-14,1.1e-27,0.106058861,-0.106058861,"neutral"]
["p.Tyr439Asp",4.53e-08,1.17e-15,0.312523197,-0.312523197,"neutral"]
["p.Tyr439Cys",0.318416188,2.28e-13,0.348171707,-0.348171707,"neutral"]
["p.Tyr439Gln",2.13e-29,4.32e-57,0.216193021,-0.216193021,"neutral"]
["p.Tyr439Ile",7.999999999999999e-24,3.39e-46,0.190412181,-0.190412181,"neutral"]
["p.Tyr439Leu",0.081754903,1.26e-05,0.43493404,-0.43493404,"neutral"]
["p.Tyr439Lys",0.133460515,7.15e-15,0.197379213,-0.197379213,"neutral"]
["p.Tyr439Met",0.088757988,0,0.146525311,-0.146525311,"neutral"]
["p.Tyr439Phe",0.00360686,1.17e-07,0.307806265,-0.307806265,"neutral"]
["p.Tyr439Thr",0.016903446,1.76e-05,0.412559939,-0.412559939,"neutral"]
["p.Tyr439Trp",6.58e-15,8.14e-29,-0.138483194,0.138483194,"neutral"]
["p.Tyr439Val",3.81e-130,1.39e-254,0.42825846,-0.42825846,"neutral"]
["p.Tyr482Leu",6.28e-06,7.61e-12,0.12939092,-0.12939092,"neutral"]
["p.Tyr482Met",4.96e-42,7.96e-82,0.174664257,-0.174664257,"neutral"]
["p.Tyr482Phe",1.01e-36,2e-71,0.192359081,-0.192359081,"neutral"]
["p.Tyr514Ala",0.261391558,1.39e-17,0.153554177,-0.153554177,"neutral"]
["p.Tyr514Gly",2.08e-61,8.37e-120,-0.420296717,0.420296717,"neutral"]
["p.Tyr514Ile",6.82e-63,1.02e-122,-0.347458804,0.347458804,"neutral"]
["p.Tyr514Leu",0.351944987,1.1e-11,-0.253257373,0.253257373,"neutral"]
["p.Tyr514Met",1.25e-42,5.27e-83,-0.238379925,0.238379925,"neutral"]
["p.Tyr514Ser",3.96e-28,1.36e-54,-0.448214351,0.448214351,"neutral"]
["p.Tyr514Thr",3.85e-06,4.57e-12,-0.260856141,0.260856141,"neutral"]
["p.Tyr514Val",2.96e-84,1.31e-164,-0.247765249,0.247765249,"neutral"]
["p.Val274Glu",4.37e-07,8.49e-14,-0.474081428,0.474081428,"neutral"]
["p.Val274Ile",0.697793339,1.11e-16,-0.279060845,0.279060845,"neutral"]
["p.Val274Lys",0.305988388,1.63e-11,-0.566249298,0.566249298,"neutral"]
["p.Val295Ala",7.08e-12,6.4e-23,0.229535138,-0.229535138,"neutral"]
["p.Val295Arg",5.04e-05,5.37e-10,0.163616612,-0.163616612,"neutral"]
["p.Val295Gly",1.32e-16,4.08e-32,0.321940598,-0.321940598,"neutral"]
["p.Val295Met",0.158721677,0.001319423,0.154634316,-0.154634316,"neutral"]
["p.Val295Phe",0.690445663,0,0.127256342,-0.127256342,"neutral"]
["p.Val295Ser",2.74e-44,2.94e-86,-0.298346678,0.298346678,"neutral"]
["p.Val295Thr",0.252264545,1.39e-17,-0.588189648,0.588189648,"neutral"]
["p.Val295Tyr",0.348619969,4.16e-17,0.397891436,-0.397891436,"neutral"]
["p.Val316Cys",1.07e-20,4.3e-40,0.146938847,-0.146938847,"neutral"]
["p.Val316Thr",0.304869436,1.39e-17,-0.135552576,0.135552576,"neutral"]
["p.Val326Ala",4.35e-12,2.38e-23,-0.072336004,0.072336004,"neutral"]
["p.Val326Cys",4.84e-10,2.1e-19,0.04622698,-0.04622698,"neutral"]
["p.Val326Gln",1.81e-15,6.64e-30,-0.021387934,0.021387934,"neutral"]
["p.Val326Gly",0.458617881,8.330000000000001e-17,0.22434294,-0.22434294,"neutral"]
["p.Val326His",0.278560971,2.78e-17,0.318399364,-0.318399364,"neutral"]
["p.Val326Ile",3.9e-10,1.49e-19,-0.21081649,0.21081649,"neutral"]
["p.Val326Leu",0.062120823,0.000217547,0.043722677,-0.043722677,"neutral"]
["p.Val326Lys",0.239664064,8.919999999999999e-06,-0.531875901,0.531875901,"neutral"]
["p.Val326Ser",4.35e-66,5.5e-129,-0.34523378,0.34523378,"neutral"]
["p.Val326Thr",1.27e-14,2.82e-28,0.129127365,-0.129127365,"neutral"]
["p.Val326Tyr",1.87e-34,5.58e-67,-0.040636209,0.040636209,"neutral"]
["p.Val331Gln",0.210419393,0,0.42084135,-0.42084135,"neutral"]
["p.Val331Glu",0.000186993,5.03e-09,-0.036184307,0.036184307,"neutral"]
["p.Val331Leu",1.35e-05,5.09e-11,-0.321763561,0.321763561,"neutral"]
["p.Val331Thr",0.356419333,0,-0.10551622,0.10551622,"neutral"]
["p.Val332Ala",1.16e-29,1.32e-57,0.113630816,-0.113630816,"neutral"]
["p.Val332His",0.258020415,3.71e-09,0.22544948,-0.22544948,"neutral"]
["p.Val332Ile",0.140229535,8.589999999999999e-09,0.228663886,-0.228663886,"neutral"]
["p.Val332Tyr",5.27e-47,1.37e-91,0.238196677,-0.238196677,"neutral"]
["p.Val340Ala",0.145617763,2.01e-09,0.355016454,-0.355016454,"neutral"]
["p.Val340Cys",1.54e-06,8.11e-13,0.026440378,-0.026440378,"neutral"]
["p.Val340Ile",4.74e-37,4.59e-72,0.303035419,-0.303035419,"neutral"]
["p.Val340Thr",0.291349698,2.78e-17,-0.343109254,0.343109254,"neutral"]
["p.Val367Asn",0.502936502,0,-0.220796679,0.220796679,"neutral"]
["p.Val367Ile",0.119094368,8.260000000000001e-06,-0.195887792,0.195887792,"neutral"]
["p.Val367Leu",1.16e-08,8.53e-17,0.285030128,-0.285030128,"neutral"]
["p.Val367Ser",3.9e-45,6.66e-88,-0.09312859499999999,0.09312859499999999,"neutral"]
["p.Val380Ile",2.45e-13,9.2e-26,0.37890576,-0.37890576,"neutral"]
["p.Val380Phe",0.486477587,8.330000000000001e-17,0.207616315,-0.207616315,"neutral"]
["p.Val386Cys",0.049269766,0.000164074,0.087462386,-0.087462386,"neutral"]
["p.Val402Ala",7.58e-16,1.19e-30,-0.052606305,0.052606305,"neutral"]
["p.Val402Arg",0.03228024,6.52e-05,-0.595220704,0.595220704,"neutral"]
["p.Val402Asn",1.89e-12,4.65e-24,0.271828471,-0.271828471,"neutral"]
["p.Val402Asp",0.494792822,1.11e-16,-0.5440095109999999,0.5440095109999999,"neutral"]
["p.Val402Cys",2.43e-44,2.32e-86,0.199971571,-0.199971571,"neutral"]
["p.Val402Gln",2.41e-25,3.85e-49,-0.470460134,0.470460134,"neutral"]
["p.Val402Gly",1.1e-44,4.99e-87,-0.451418201,0.451418201,"neutral"]
["p.Val402Leu",0.093396494,2.67e-10,-0.143936758,0.143936758,"neutral"]
["p.Val402Met",0.000351615,2.06e-08,-0.472495165,0.472495165,"neutral"]
["p.Val402Ser",0.047983516,0.000166954,-0.311014438,0.311014438,"neutral"]
["p.Val402Thr",0.115308974,0,-0.132310345,0.132310345,"neutral"]
["p.Val402Tyr",0.135912119,1.01e-10,-0.224275343,0.224275343,"neutral"]
["p.Val405Ile",0.067987491,0.000122363,-0.073027604,0.073027604,"neutral"]
["p.Val405Leu",9.010000000000001e-08,3.6e-15,-0.170560574,0.170560574,"neutral"]
["p.Val448Arg",4.83e-26,1.63e-50,0.330135074,-0.330135074,"neutral"]
["p.Val448Gly",0.21145523,0,0.158888585,-0.158888585,"neutral"]
["p.Val448Thr",0.541241269,1.21e-11,-0.434431756,0.434431756,"neutral"]
["p.Val448Tyr",5.05e-53,2.42e-103,-0.614753218,0.614753218,"neutral"]
["p.Val464Ala",4.64e-28,1.82e-54,-0.3227813,0.3227813,"neutral"]
["p.Val464Arg",0.667930329,1.31e-12,-0.229776324,0.229776324,"neutral"]
["p.Val464Asn",2.48e-26,4.29e-51,-0.512528092,0.512528092,"neutral"]
["p.Val464Asp",1.29e-05,4.53e-11,0.332329347,-0.332329347,"neutral"]
["p.Val464Cys",1.15e-18,3.97e-36,-0.50972386,0.50972386,"neutral"]
["p.Val464Glu",0.13192148,6.94e-18,-0.112449534,0.112449534,"neutral"]
["p.Val464Gly",1.46e-23,1.12e-45,-0.625884873,0.625884873,"neutral"]
["p.Val464Ile",2.57e-10,6.17e-20,-0.299680172,0.299680172,"neutral"]
["p.Val464Leu",7.009999999999999e-30,5.14e-58,0.004598571,-0.004598571,"neutral"]
["p.Val464Met",5.05e-10,2.43e-19,-0.49610467,0.49610467,"neutral"]
["p.Val464Phe",9.079999999999999e-15,1.54e-28,0.012438285,-0.012438285,"neutral"]
["p.Val464Pro",1.08e-10,1.16e-20,-0.482273481,0.482273481,"neutral"]
["p.Val464Trp",1.34e-52,1.54e-102,-0.150785096,0.150785096,"neutral"]
["p.Val464Tyr",2.87e-51,6.08e-100,-0.297698629,0.297698629,"neutral"]
["p.Val470Ala",0.283343052,8.330000000000001e-17,-0.525165966,0.525165966,"neutral"]
["p.Val470Arg",7.68e-09,3.92e-17,0.339924406,-0.339924406,"neutral"]
["p.Val470Cys",2.13e-84,7.08e-165,-0.462666444,0.462666444,"neutral"]
["p.Val470Gln",0.459952431,1.39e-16,0.091859414,-0.091859414,"neutral"]
["p.Val470Glu",0.43860446,0,-0.518665293,0.518665293,"neutral"]
["p.Val470Leu",9.93e-23,4.62e-44,0.379025512,-0.379025512,"neutral"]
["p.Val470Met",2.02e-08,2.36e-16,0.141811102,-0.141811102,"neutral"]
["p.Val470Phe",4.57e-27,1.58e-52,0.191132165,-0.191132165,"neutral"]
["p.Val470Trp",3.01e-12,1.17e-23,0.237821123,-0.237821123,"neutral"]
["p.Val478Ala",0.133811341,0,0.09046246099999999,-0.09046246099999999,"neutral"]
["p.Val478Leu",6.100000000000001e-14,6.21e-27,0.405944551,-0.405944551,"neutral"]
["p.Val478Met",0.191174581,0,0.436288545,-0.436288545,"neutral"]
["p.Ala330Arg",4.05e-46,8.21e-90,-1.242812941,1.242812941,"gain of function"]
["p.Ala330His",7.69e-30,6.33e-58,-0.747190587,0.747190587,"gain of function"]
["p.Ala330Phe",0.006049341,1.35e-06,-0.684691016,0.684691016,"gain of function"]
["p.Ala330Trp",2.09e-18,1.46e-35,-2.599931831,2.599931831,"gain of function"]
["p.Ala330Tyr",6.77e-24,2.69e-46,-0.978025795,0.978025795,"gain of function"]
["p.Ala374Cys",4.43e-26,1.43e-50,-0.934354127,0.934354127,"gain of function"]
["p.Ala378Arg",1.48e-40,6.49e-79,-1.278375372,1.278375372,"gain of function"]
["p.Ala378Asn",9.670000000000001e-10,8.39e-19,-1.027954264,1.027954264,"gain of function"]
["p.Ala378Asp",6.23e-13,6.15e-25,-1.909679562,1.909679562,"gain of function"]
["p.Ala378Gly",3.28e-22,5.13e-43,-0.815634482,0.815634482,"gain of function"]
["p.Ala378Leu",2.75e-29,7.83e-57,-1.577266131,1.577266131,"gain of function"]
["p.Ala378Met",1.99e-43,1.57e-84,-1.717143709,1.717143709,"gain of function"]
["p.Ala378Thr",1.1e-33,1.86e-65,-1.140131661,1.140131661,"gain of function"]
["p.Ala378Tyr",5.52e-20,1.15e-38,-1.368151914,1.368151914,"gain of function"]
["p.Ala393Asp",0.701836583,0.009201605999999999,-1.30838278,1.30838278,"gain of function"]
["p.Ala406Gly",0.314467201,6.94e-17,-0.755575784,0.755575784,"gain of function"]
["p.Ala425Ser",2.44e-14,1.17e-27,-2.005377606,2.005377606,"gain of function"]
["p.Ala433Asp",6.22e-16,8.54e-31,-1.069768469,1.069768469,"gain of function"]
["p.Ala433Cys",0.366532506,0,-0.773749621,0.773749621,"gain of function"]
["p.Ala433Pro",5.19e-37,5.85e-72,-2.064011357,2.064011357,"gain of function"]
["p.Ala437Gly",2.84e-14,1.43e-27,-1.12485763,1.12485763,"gain of function"]
["p.Arg271Trp",2.76e-60,1.34e-117,-0.688817445,0.688817445,"gain of function"]
["p.Arg321Gly",2.21e-77,4.05e-151,-0.685315609,0.685315609,"gain of function"]
["p.Arg321Ser",1.9e-28,3.32e-55,-1.085460573,1.085460573,"gain of function"]
["p.Arg382Asp",0.319691636,1.39e-17,-0.736017479,0.736017479,"gain of function"]
["p.Arg382His",1.35e-06,7.45e-13,-0.674387092,0.674387092,"gain of function"]
["p.Arg382Tyr",1.79e-05,9.75e-11,-0.709787219,0.709787219,"gain of function"]
["p.Arg391Ter",6.43e-15,8.57e-29,-0.689749455,0.689749455,"gain of function"]
["p.Arg422Ser",2.34e-56,6.9e-110,-1.013422301,1.013422301,"gain of function"]
["p.Arg472Leu",1.67e-91,8.43e-179,-1.042844117,1.042844117,"gain of function"]
["p.Arg472Phe",1.6e-11,3.38e-22,-1.477531791,1.477531791,"gain of function"]
["p.Arg472Tyr",4.93e-89,5.93e-174,-0.67180853,0.67180853,"gain of function"]
["p.Arg472Val",2.75e-81,9.01e-159,-0.768704321,0.768704321,"gain of function"]
["p.Arg503Asp",7.010000000000001e-27,3.78e-52,-0.650183085,0.650183085,"gain of function"]
["p.Asn290Asp",3.24e-47,5.86e-92,-1.536942096,1.536942096,"gain of function"]
["p.Asn290Glu",1.03e-59,1.79e-116,-0.880033115,0.880033115,"gain of function"]
["p.Asn290Ile",6.47e-43,1.52e-83,-0.703947994,0.703947994,"gain of function"]
["p.Asn290Phe",1.85e-12,4.73e-24,-0.934325622,0.934325622,"gain of function"]
["p.Asn290Pro",1.42e-46,1.04e-90,-0.978433339,0.978433339,"gain of function"]
["p.Asn290Trp",4.34e-27,1.53e-52,-1.249938533,1.249938533,"gain of function"]
["p.Asn290Tyr",1.03e-19,3.8e-38,-0.945067,0.945067,"gain of function"]
["p.Asn384Arg",4.59e-08,1.26e-15,-0.827413827,0.827413827,"gain of function"]
["p.Asn384Ser",1.74e-21,1.33e-41,-0.698201472,0.698201472,"gain of function"]
["p.Asn417Gly",4.51e-47,1.13e-91,-1.940288112,1.940288112,"gain of function"]
["p.Asp368Ala",6.99e-91,1.43e-177,-1.399692706,1.399692706,"gain of function"]
["p.Asp368Arg",1.39e-43,7.69e-85,-1.508267807,1.508267807,"gain of function"]
["p.Asp368Asn",1.79e-38,8.02e-75,-1.404092166,1.404092166,"gain of function"]
["p.Asp368Gly",7.65e-22,2.71e-42,-0.784382278,0.784382278,"gain of function"]
["p.Asp368His",1.26e-14,3.15e-28,-0.809844055,0.809844055,"gain of function"]
["p.Asp368Ile",2.66e-45,3.16e-88,-0.739138348,0.739138348,"gain of function"]
["p.Asp368Leu",3.1e-44,4.02e-86,-1.047693094,1.047693094,"gain of function"]
["p.Asp368Phe",1.47e-10,2.34e-20,-1.12601145,1.12601145,"gain of function"]
["p.Asp368Pro",7.63e-17,1.56e-32,-1.177257026,1.177257026,"gain of function"]
["p.Asp368Ser",1.5e-72,1.24e-141,-1.25347702,1.25347702,"gain of function"]
["p.Asp368Thr",1.05e-08,8.01e-17,-0.876225763,0.876225763,"gain of function"]
["p.Asp368Trp",0.754464542,0,-0.718879388,0.718879388,"gain of function"]
["p.Asp368Tyr",1.97e-38,9.47e-75,-1.179148745,1.179148745,"gain of function"]
["p.Asp368Val",2.48e-71,3.03e-139,-1.221492954,1.221492954,"gain of function"]
["p.Asp447Glu",0.391610147,2.69e-05,-0.831460406,0.831460406,"gain of function"]
["p.Asp496Arg",1.11374166,8.33e-08,-1.035729159,1.035729159,"gain of function"]
["p.Asp496Tyr",0.251351066,1.39e-17,-0.708511775,0.708511775,"gain of function"]
["p.Cys499His",3.27e-06,3.47e-12,-0.639937457,0.639937457,"gain of function"]
["p.Cys499Lys",0.371141586,0.000252576,-0.805742289,0.805742289,"gain of function"]
["p.Cys499Tyr",6.71e-28,3.96e-54,-1.241885245,1.241885245,"gain of function"]
["p.Gln278Glu",1.4e-55,2.38e-108,-2.285632878,2.285632878,"gain of function"]
["p.Gln312Phe",1.53e-09,2.07e-18,-0.914509126,0.914509126,"gain of function"]
["p.Gln312Tyr",6.959999999999999e-30,5.26e-58,-1.342045606,1.342045606,"gain of function"]
["p.Gln315Asn",6.38e-50,2.81e-97,-0.894657522,0.894657522,"gain of function"]
["p.Gln315Asp",0.553155206,2.3e-10,-0.921193982,0.921193982,"gain of function"]
["p.Gln327Asp",2.89e-38,2.06e-74,-1.560169167,1.560169167,"gain of function"]
["p.Gln327Ser",2.25e-27,4.14e-53,-0.7555783780000001,0.7555783780000001,"gain of function"]
["p.Gln327Thr",3.68e-45,6.16e-88,-1.113535177,1.113535177,"gain of function"]
["p.Gln365Met",7.44e-11,6.12e-21,-1.214646146,1.214646146,"gain of function"]
["p.Gln372Lys",1.25e-29,1.65e-57,-2.274815742,2.274815742,"gain of function"]
["p.Gln423Pro",1.6e-21,1.16e-41,-1.232773542,1.232773542,"gain of function"]
["p.Gln477Ile",0.822159757,0,-1.181871708,1.181871708,"gain of function"]
["p.Gln477Leu",1.2e-28,1.37e-55,-1.115539245,1.115539245,"gain of function"]
["p.Gln477Met",2.57e-20,2.53e-39,-0.864785092,0.864785092,"gain of function"]
["p.Gln477Phe",6.149999999999999e-11,4.09e-21,-1.240627765,1.240627765,"gain of function"]
["p.Gln477Trp",3.52e-79,1.25e-154,-1.615659884,1.615659884,"gain of function"]
["p.Gln477Tyr",1.65e-59,4.46e-116,-0.916104371,0.916104371,"gain of function"]
["p.Gln477Val",3.47e-25,7.73e-49,-0.866347191,0.866347191,"gain of function"]
["p.Gln500Phe",6.95e-43,1.68e-83,-0.840485361,0.840485361,"gain of function"]
["p.Gln500Trp",9.71e-26,6.52e-50,-1.015997787,1.015997787,"gain of function"]
["p.Gln516Ile",0.000183283,6.38e-09,-1.414419604,1.414419604,"gain of function"]
["p.Gln516Pro",2.409429911,0,-2.294256952,2.294256952,"gain of function"]
["p.Glu273Ala",0.481808203,0.004970234,-1.46288858,1.46288858,"gain of function"]
["p.Glu273Arg",3.01e-31,1.13e-60,-1.574819856,1.574819856,"gain of function"]
["p.Glu273Asn",6.259999999999999e-26,2.83e-50,-0.715050427,0.715050427,"gain of function"]
["p.Glu273Cys",0.190956397,3.14e-06,-0.697641672,0.697641672,"gain of function"]
["p.Glu273Gly",1.2e-37,3.44e-73,-4.071049985,4.071049985,"gain of function"]
["p.Glu273Ile",1.01e-10,1.11e-20,-1.504280236,1.504280236,"gain of function"]
["p.Glu273Leu",1.47e-24,1.33e-47,-1.061536887,1.061536887,"gain of function"]
["p.Glu273Met",1.23e-28,1.45e-55,-1.409398032,1.409398032,"gain of function"]
["p.Glu273Pro",5.46e-44,1.25e-85,-1.646656051,1.646656051,"gain of function"]
["p.Glu273Ser",8.16e-18,2.03e-34,-2.991642099,2.991642099,"gain of function"]
["p.Glu273Thr",3.11e-19,3.46e-37,-1.30650704,1.30650704,"gain of function"]
["p.Glu283Gln",0.000132079,3.22e-09,-1.241399959,1.241399959,"gain of function"]
["p.Glu283Leu",9.400000000000001e-37,1.93e-71,-3.64916427,3.64916427,"gain of function"]
["p.Glu283Lys",4.15e-42,6.11e-82,-3.37467758,3.37467758,"gain of function"]
["p.Glu283Met",1.49e-35,4.3e-69,-3.801163899,3.801163899,"gain of function"]
["p.Glu283Thr",1.76e-58,4.83e-114,-1.453740651,1.453740651,"gain of function"]
["p.Glu283Val",1.26e-25,1.18e-49,-2.828453872,2.828453872,"gain of function"]
["p.Glu323Arg",2.58e-62,1.46e-121,-1.616223062,1.616223062,"gain of function"]
["p.Glu323Lys",1.99e-09,3.43e-18,-1.271800677,1.271800677,"gain of function"]
["p.Glu334Cys",8.02e-39,1.57e-75,-1.124708309,1.124708309,"gain of function"]
["p.Glu334Phe",7.69e-09,4.58e-17,-1.643554095,1.643554095,"gain of function"]
["p.Glu335Ala",3.87e-52,1.28e-101,-1.026979927,1.026979927,"gain of function"]
["p.Glu335Arg",1.74e-09,2.8e-18,-2.336565581,2.336565581,"gain of function"]
["p.Glu335Asn",1.1e-28,1.21e-55,-1.86248202,1.86248202,"gain of function"]
["p.Glu335Asp",1.8e-26,2.4e-51,-0.991829373,0.991829373,"gain of function"]
["p.Glu335Cys",4.46e-10,1.91e-19,-1.490287239,1.490287239,"gain of function"]
["p.Glu335Ile",1.14e-64,3.54e-126,-1.754949284,1.754949284,"gain of function"]
["p.Glu335Leu",1.78e-12,4.76e-24,-1.865311918,1.865311918,"gain of function"]
["p.Glu335Lys",1.21e-20,6.27e-40,-2.408038113,2.408038113,"gain of function"]
["p.Glu335Met",0.000396333,2.23e-08,-1.396329853,1.396329853,"gain of function"]
["p.Glu335Ser",1.91e-25,2.43e-49,-1.316211614,1.316211614,"gain of function"]
["p.Glu335Thr",5.1e-20,9.76e-39,-1.202622362,1.202622362,"gain of function"]
["p.Glu335Val",3.34e-38,2.54e-74,-0.77576416,0.77576416,"gain of function"]
["p.Glu356Arg",1.04e-37,2.43e-73,-0.974364919,0.974364919,"gain of function"]
["p.Glu356Ile",1.62e-79,2.61e-155,-0.636583997,0.636583997,"gain of function"]
["p.Glu356Met",3.71e-27,1.08e-52,-0.764701348,0.764701348,"gain of function"]
["p.Glu356Trp",2.07e-56,5.57e-110,-1.458035223,1.458035223,"gain of function"]
["p.Glu381Arg",1.36e-37,4.41e-73,-4.878074728,4.878074728,"gain of function"]
["p.Glu381Gly",1.09e-18,4.05e-36,-3.102127021,3.102127021,"gain of function"]
["p.Glu381Leu",4.04e-54,1.69e-105,-2.097141803,2.097141803,"gain of function"]
["p.Glu381Met",5.89e-53,3.4e-103,-4.320913786,4.320913786,"gain of function"]
["p.Glu381Ser",3.26e-23,6.02e-45,-3.593995599,3.593995599,"gain of function"]
["p.Glu381Thr",5.73e-12,4.66e-23,-3.366932103,3.366932103,"gain of function"]
["p.Glu381Tyr",1.63e-60,5.14e-118,-3.650602879,3.650602879,"gain of function"]
["p.Glu381Val",2.24e-20,2.11e-39,-2.913513866,2.913513866,"gain of function"]
["p.Glu399His",1.933764165,1.33e-15,-1.762684579,1.762684579,"gain of function"]
["p.Glu399Pro",7.82e-55,6.49e-107,-0.977542213,0.977542213,"gain of function"]
["p.Glu399Ser",1.82e-14,6.43e-28,-0.799380646,0.799380646,"gain of function"]
["p.Glu418Val",1.06e-35,2.15e-69,-1.646215121,1.646215121,"gain of function"]
["p.Glu473Thr",0.817825688,0,-0.893829406,0.893829406,"gain of function"]
["p.Glu479His",3.02e-67,3e-131,-0.752854545,0.752854545,"gain of function"]
["p.Glu492Phe",2.85e-59,1.32e-115,-0.704995381,0.704995381,"gain of function"]
["p.Glu492Tyr",0.169409509,5.2e-12,-0.991330764,0.991330764,"gain of function"]
["p.Glu505Met",2.96e-10,8.069999999999999e-20,-0.654503215,0.654503215,"gain of function"]
["p.Glu505Trp",0.468094666,5.79e-07,-1.143982219,1.143982219,"gain of function"]
["p.Glu507Cys",7.38e-29,5.31e-56,-0.781965335,0.781965335,"gain of function"]
["p.Glu507Gln",1.29e-38,4.17e-75,-0.925160363,0.925160363,"gain of function"]
["p.Glu508Arg",5.22e-121,1.14e-236,-0.65073705,0.65073705,"gain of function"]
["p.Glu508Cys",3.9e-103,1.29e-201,-0.86404338,0.86404338,"gain of function"]
["p.Glu508His",1.1e-05,3.69e-11,-1.325115574,1.325115574,"gain of function"]
["p.Glu508Phe",1.218749516,1.33e-15,-1.562098428,1.562098428,"gain of function"]
["p.Glu508Pro",2.21e-77,4.09e-151,-0.680537509,0.680537509,"gain of function"]
["p.Glu508Trp",1.32e-41,5.72e-81,-1.895542524,1.895542524,"gain of function"]
["p.Glu508Tyr",5.42e-68,1.06e-132,-0.749246007,0.749246007,"gain of function"]
["p.Glu513Ile",7.389999999999999e-63,1.22e-122,-1.000036576,1.000036576,"gain of function"]
["p.Glu513Met",4.95e-07,1.05e-13,-0.64630765,0.64630765,"gain of function"]
["p.Glu513Pro",4.28e-19,6.36e-37,-1.168164099,1.168164099,"gain of function"]
["p.Glu513Thr",1.14e-55,1.53e-108,-0.899282832,0.899282832,"gain of function"]
["p.Gly287Ser",7.17e-62,1.07e-120,-1.395841375,1.395841375,"gain of function"]
["p.Gly291Lys",0.410842956,0,-0.736228534,0.736228534,"gain of function"]
["p.Gly291Phe",7.92e-06,1.89e-11,-0.649232735,0.649232735,"gain of function"]
["p.Gly291Pro",6.26e-15,8.09e-29,-1.44502794,1.44502794,"gain of function"]
["p.Gly291Trp",1.88e-17,9.879999999999999e-34,-0.850197249,0.850197249,"gain of function"]
["p.Gly291Tyr",0.102181166,0.00061107,-0.776283494,0.776283494,"gain of function"]
["p.Gly398Asn",0.000178685,5.28e-09,-1.538180472,1.538180472,"gain of function"]
["p.Gly398Asp",0.389572211,1.51e-09,-0.734082703,0.734082703,"gain of function"]
["p.Gly440Leu",7.91e-25,3.98e-48,-1.021361803,1.021361803,"gain of function"]
["p.Gly440Tyr",3.26e-18,3.2e-35,-0.823248626,0.823248626,"gain of function"]
["p.Gly468Cys",1.441020428,0,-1.089447149,1.089447149,"gain of function"]
["p.Gly468Tyr",0.377031389,0,-0.830610907,0.830610907,"gain of function"]
["p.Ile429Val",3.04e-20,3.56e-39,-1.495256519,1.495256519,"gain of function"]
["p.Ile444Ala",3.38e-97,5.93e-190,-1.664838485,1.664838485,"gain of function"]
["p.Ile444Arg",2.49e-51,5.12e-100,-2.263666168,2.263666168,"gain of function"]
["p.Ile444Asp",1.15e-64,3.54e-126,-0.930570785,0.930570785,"gain of function"]
["p.Ile444Cys",6.05e-06,1.31e-11,-2.215302998,2.215302998,"gain of function"]
["p.Ile444Gln",1.43e-59,3.54e-116,-2.205584912,2.205584912,"gain of function"]
["p.Ile444Glu",3.4e-12,1.65e-23,-1.324174829,1.324174829,"gain of function"]
["p.Ile444Gly",2.99e-42,3.12e-82,-1.172021399,1.172021399,"gain of function"]
["p.Ile444His",5.39e-29,2.96e-56,-2.601052951,2.601052951,"gain of function"]
["p.Ile444Leu",1.63e-51,2.18e-100,-1.590548185,1.590548185,"gain of function"]
["p.Ile444Lys",1.4e-05,7.35e-11,-2.979018493,2.979018493,"gain of function"]
["p.Ile444Met",7.92e-29,5.97e-56,-0.886450365,0.886450365,"gain of function"]
["p.Ile444Pro",1.2e-30,1.73e-59,-2.726666976,2.726666976,"gain of function"]
["p.Ile444Ser",4.38e-64,4.95e-125,-1.246410216,1.246410216,"gain of function"]
["p.Ile444Thr",9.400000000000001e-21,3.81e-40,-1.998223836,1.998223836,"gain of function"]
["p.Ile444Tyr",3.63e-26,1.01e-50,-1.569055735,1.569055735,"gain of function"]
["p.Ile444Val",5.11e-39,6.83e-76,-1.348264004,1.348264004,"gain of function"]
["p.Leu270Val",5.36e-28,2.54e-54,-1.452654149,1.452654149,"gain of function"]
["p.Leu276Gly",1.59e-25,1.8e-49,-1.797458359,1.797458359,"gain of function"]
["p.Leu276Phe",3.87e-08,9.96e-16,-1.755849516,1.755849516,"gain of function"]
["p.Leu276Thr",2.64e-07,3.89e-14,-2.712538146,2.712538146,"gain of function"]
["p.Leu300Arg",1.08e-16,3.22e-32,-2.973358885,2.973358885,"gain of function"]
["p.Leu300Asn",0.108653607,0.000653494,-0.700457443,0.700457443,"gain of function"]
["p.Leu300Lys",0.808763715,1.32e-11,-0.996899435,0.996899435,"gain of function"]
["p.Leu300Pro",1.74e-16,7.74e-32,-1.114191134,1.114191134,"gain of function"]
["p.Leu325Ala",1.16e-34,2.25e-67,-0.734428542,0.734428542,"gain of function"]
["p.Leu325Cys",9.39e-14,1.45e-26,-0.8828036379999999,0.8828036379999999,"gain of function"]
["p.Leu325Ile",7.47e-39,1.39e-75,-0.991919167,0.991919167,"gain of function"]
["p.Leu325Thr",2.67e-25,4.87e-49,-1.20493392,1.20493392,"gain of function"]
["p.Leu325Val",1.03e-09,9.46e-19,-0.741994803,0.741994803,"gain of function"]
["p.Leu349Ala",6.85e-12,6.100000000000001e-23,-0.866112189,0.866112189,"gain of function"]
["p.Leu349Ile",2.73e-13,1.15e-25,-0.706530443,0.706530443,"gain of function"]
["p.Leu350Ala",6.47e-25,2.74e-48,-1.718607224,1.718607224,"gain of function"]
["p.Leu350Arg",6.32e-81,4.61e-158,-1.006749238,1.006749238,"gain of function"]
["p.Leu350Asp",2.67e-35,1.3e-68,-1.30067522,1.30067522,"gain of function"]
["p.Leu350Phe",4.53e-35,3.7e-68,-0.78647398,0.78647398,"gain of function"]
["p.Leu350Ser",7.73e-23,3.12e-44,-1.169366931,1.169366931,"gain of function"]
["p.Leu350Thr",5.77e-28,2.88e-54,-0.777631133,0.777631133,"gain of function"]
["p.Leu350Tyr",3.24e-21,4.64e-41,-1.532230845,1.532230845,"gain of function"]
["p.Leu350Val",7.819999999999999e-49,3.83e-95,-0.843322922,0.843322922,"gain of function"]
["p.Leu361Met",6.26e-06,1.09e-11,-0.8318130379999999,0.8318130379999999,"gain of function"]
["p.Leu413Arg",6.61e-13,6.86e-25,-1.339833657,1.339833657,"gain of function"]
["p.Leu413Gln",1.12e-16,3.31e-32,-1.151696308,1.151696308,"gain of function"]
["p.Leu413Lys",1.51e-43,9.3e-85,-2.255301683,2.255301683,"gain of function"]
["p.Leu413Pro",0.000118779,2.75e-09,-0.977837345,0.977837345,"gain of function"]
["p.Leu438Trp",0.242986524,0.001420446,-0.868602195,0.868602195,"gain of function"]
["p.Leu454Trp",3.97e-23,8.02e-45,-0.730998277,0.730998277,"gain of function"]
["p.Leu494Phe",3.97e-73,8.719999999999999e-143,-0.632199701,0.632199701,"gain of function"]
["p.Lys275Ala",1.587213035,9.659999999999999e-07,-2.787682681,2.787682681,"gain of function"]
["p.Lys275Gly",3.08e-23,5.36e-45,-1.859552471,1.859552471,"gain of function"]
["p.Lys275His",5.67e-05,8.04e-10,-1.443688476,1.443688476,"gain of function"]
["p.Lys275Ile",9.79e-20,3.53e-38,-1.303238476,1.303238476,"gain of function"]
["p.Lys275Met",1.67e-19,9.87e-38,-0.8246521060000001,0.8246521060000001,"gain of function"]
["p.Lys275Tyr",3.06e-38,2.32e-74,-1.882870745,1.882870745,"gain of function"]
["p.Lys275Val",5.37e-46,1.44e-89,-1.852747169,1.852747169,"gain of function"]
["p.Lys301Ile",1.44e-18,6.96e-36,-2.069902304,2.069902304,"gain of function"]
["p.Lys319Glu",1.57e-43,9.35e-85,-0.9811749279999999,0.9811749279999999,"gain of function"]
["p.Lys319His",0.0006861219999999999,5.11e-08,-0.8067718230000001,0.8067718230000001,"gain of function"]
["p.Lys346Pro",3.08e-23,5.17e-45,-1.303727281,1.303727281,"gain of function"]
["p.Lys354Arg",1.56e-13,3.88e-26,-0.717564482,0.717564482,"gain of function"]
["p.Lys359Phe",0.610158451,1.67e-16,-0.80850853,0.80850853,"gain of function"]
["p.Lys404Arg",0.983301771,0,-0.78707805,0.78707805,"gain of function"]
["p.Lys404Asn",1.28e-21,7.61e-42,-1.680276508,1.680276508,"gain of function"]
["p.Lys404His",0.516260786,1.19e-09,-0.774692476,0.774692476,"gain of function"]
["p.Lys404Thr",7.78e-21,2.53e-40,-0.968667645,0.968667645,"gain of function"]
["p.Lys426Ile",4.15e-32,2.26e-62,-1.180602073,1.180602073,"gain of function"]
["p.Lys426Leu",6.71e-102,3.48e-199,-0.914105732,0.914105732,"gain of function"]
["p.Lys426Pro",3.74e-22,6.96e-43,-2.028068738,2.028068738,"gain of function"]
["p.Lys426Val",5.92e-26,2.46e-50,-0.684268808,0.684268808,"gain of function"]
["p.Lys445Ala",1.57e-42,8.63e-83,-0.633866623,0.633866623,"gain of function"]
["p.Lys445Asn",2.25e-47,2.73e-92,-0.725468692,0.725468692,"gain of function"]
["p.Lys445Gly",1.87e-27,2.93e-53,-1.045066235,1.045066235,"gain of function"]
["p.Lys445Thr",4.63e-09,1.59e-17,-0.7050698949999999,0.7050698949999999,"gain of function"]
["p.Lys504Cys",2.53e-38,1.5e-74,-1.287107674,1.287107674,"gain of function"]
["p.Met286Arg",4.45e-100,1.3e-195,-0.879187819,0.879187819,"gain of function"]
["p.Met286Asp",1.17e-08,9e-17,-0.70748546,0.70748546,"gain of function"]
["p.Met286Gly",1.65e-43,1.11e-84,-2.588876848,2.588876848,"gain of function"]
["p.Met286Phe",1.03e-17,3e-34,-0.820186867,0.820186867,"gain of function"]
["p.Met286Tyr",1.96e-18,1.21e-35,-0.6544344010000001,0.6544344010000001,"gain of function"]
["p.Met344Ala",0.000166892,4.35e-09,-1.273592604,1.273592604,"gain of function"]
["p.Met377Ala",9.17e-60,1.46e-116,-1.198458913,1.198458913,"gain of function"]
["p.Met377Gly",4.59e-80,2.21e-156,-0.701060952,0.701060952,"gain of function"]
["p.Met377Ser",4.36e-17,4.82e-33,-0.768645306,0.768645306,"gain of function"]
["p.Met377Val",1.81e-31,4.06e-61,-0.964295924,0.964295924,"gain of function"]
["p.Phe352Val",0.130298517,0.000571261,-0.740912675,0.740912675,"gain of function"]
["p.Phe512Ala",9.04e-15,1.64e-28,-1.317114969,1.317114969,"gain of function"]
["p.Phe512Ile",5.13e-39,6.9e-76,-2.059510156,2.059510156,"gain of function"]
["p.Phe512Met",4.25e-15,3.83e-29,-1.293437216,1.293437216,"gain of function"]
["p.Phe512Pro",4.85e-60,4.32e-117,-2.61284665,2.61284665,"gain of function"]
["p.Phe512Thr",0.004585366,6.12e-07,-0.85161358,0.85161358,"gain of function"]
["p.Phe512Trp",3.32e-31,1.42e-60,-3.794427319,3.794427319,"gain of function"]
["p.Phe512Val",3.02e-70,4.15e-137,-1.99843609,1.99843609,"gain of function"]
["p.Pro302Asp",6e-49,2.34e-95,-1.408055584,1.408055584,"gain of function"]
["p.Pro302Phe",2.48e-41,1.96e-80,-1.021492261,1.021492261,"gain of function"]
["p.Pro302Trp",8.02e-23,3.34e-44,-0.856451414,0.856451414,"gain of function"]
["p.Pro302Tyr",1.45e-43,8.489999999999999e-85,-2.129842477,2.129842477,"gain of function"]
["p.Pro307Asn",6.7e-73,2.63e-142,-2.364868657,2.364868657,"gain of function"]
["p.Pro307Asp",3.48e-22,5.89e-43,-0.913469189,0.913469189,"gain of function"]
["p.Pro307Gln",5.61e-56,3.74e-109,-0.631183651,0.631183651,"gain of function"]
["p.Pro307Glu",3.59e-28,1.13e-54,-0.726750293,0.726750293,"gain of function"]
["p.Pro307His",9.24e-31,9.840000000000001e-60,-0.634139557,0.634139557,"gain of function"]
["p.Pro307Ser",1.13e-66,4.12e-130,-1.053068536,1.053068536,"gain of function"]
["p.Pro307Trp",6.59e-07,2.01e-13,-0.638748349,0.638748349,"gain of function"]
["p.Pro434Cys",8.960000000000001e-06,2.47e-11,-0.7276944359999999,0.7276944359999999,"gain of function"]
["p.Pro434Ile",5.79e-12,4.19e-23,-0.813977053,0.813977053,"gain of function"]
["p.Pro434Met",4.21e-38,4.07e-74,-0.689845306,0.689845306,"gain of function"]
["p.Pro434Thr",1.99e-73,2.34e-143,-0.68501838,0.68501838,"gain of function"]
["p.Pro487Cys",9.8e-64,2.36e-124,-0.97093807,0.97093807,"gain of function"]
["p.Pro488Cys",0.853506515,1.11e-16,-0.765759339,0.765759339,"gain of function"]
["p.Pro488Ile",4.03e-26,1.21e-50,-3.131433646,3.131433646,"gain of function"]
["p.Pro488Tyr",5.9e-42,1.15e-81,-0.727118203,0.727118203,"gain of function"]
["p.Pro506Arg",2.26e-90,1.43e-176,-1.715751934,1.715751934,"gain of function"]
["p.Pro506Asn",7.48e-41,1.69e-79,-0.76532559,0.76532559,"gain of function"]
["p.Pro506Gln",2.23e-30,5.47e-59,-0.665741501,0.665741501,"gain of function"]
["p.Pro506Ile",2.07e-53,4.12e-104,-1.014056998,1.014056998,"gain of function"]
["p.Pro506Lys",1.75e-52,2.75e-102,-1.807220877,1.807220877,"gain of function"]
["p.Pro506Phe",0.000107562,2.33e-09,-0.846564395,0.846564395,"gain of function"]
["p.Pro506Trp",2.01e-14,7.67e-28,-0.826500361,0.826500361,"gain of function"]
["p.Pro506Tyr",2.62e-39,1.8e-76,-0.848718819,0.848718819,"gain of function"]
["p.Ser345Arg",7.35e-17,1.41e-32,-1.655501196,1.655501196,"gain of function"]
["p.Ser345Gln",0.9668420680000001,0,-0.91363189,0.91363189,"gain of function"]
["p.Ser345Leu",1.36e-45,8.64e-89,-1.102569359,1.102569359,"gain of function"]
["p.Ser348Asn",2.28e-57,7.19e-112,-1.182895335,1.182895335,"gain of function"]
["p.Ser348Asp",1.16e-22,7.11e-44,-1.951765631,1.951765631,"gain of function"]
["p.Ser375Arg",9.62e-11,9.41e-21,-0.637717924,0.637717924,"gain of function"]
["p.Ser375Asn",0.401936979,7.46e-06,-0.838711772,0.838711772,"gain of function"]
["p.Ser375Cys",1.82e-07,1.61e-14,-0.825019023,0.825019023,"gain of function"]
["p.Ser375His",5.7e-27,2.55e-52,-0.800476624,0.800476624,"gain of function"]
["p.Ser375Phe",2.61e-21,3.08e-41,-0.648274131,0.648274131,"gain of function"]
["p.Ser450Met",8.759999999999999e-38,1.68e-73,-0.677494154,0.677494154,"gain of function"]
["p.Thr292Arg",0.515507641,5.55e-17,-0.658189436,0.658189436,"gain of function"]
["p.Thr292Trp",4.55e-51,1.6e-99,-1.306271179,1.306271179,"gain of function"]
["p.Thr292Tyr",1.55e-24,1.47e-47,-0.874855399,0.874855399,"gain of function"]
["p.Thr292Val",0.279866249,0,-0.69971689,0.69971689,"gain of function"]
["p.Thr293Arg",5.52e-46,1.49e-89,-0.905411251,0.905411251,"gain of function"]
["p.Thr293Asp",4.77e-21,9.790000000000001e-41,-1.123706167,1.123706167,"gain of function"]
["p.Thr293Gly",1.25e-31,2e-61,-1.109158137,1.109158137,"gain of function"]
["p.Thr293Lys",2.2e-06,1.73e-12,-0.778232659,0.778232659,"gain of function"]
["p.Thr293Trp",7.29e-26,3.8e-50,-1.121049943,1.121049943,"gain of function"]
["p.Thr299Leu",2.54e-23,3.46e-45,-0.729024206,0.729024206,"gain of function"]
["p.Thr299Met",2.2e-15,1.03e-29,-1.482349716,1.482349716,"gain of function"]
["p.Thr299Phe",6.56e-13,7.17e-25,-2.845159382,2.845159382,"gain of function"]
["p.Thr299Tyr",2.22e-40,1.44e-78,-1.212345515,1.212345515,"gain of function"]
["p.Thr304Arg",4.66e-33,3.25e-64,-1.788887715,1.788887715,"gain of function"]
["p.Thr304Gln",2.07e-05,1.27e-10,-1.81897865,1.81897865,"gain of function"]
["p.Thr304Lys",4.92e-14,4.65e-27,-2.097839826,2.097839826,"gain of function"]
["p.Thr341Ile",2.35e-37,1.24e-72,-2.54675833,2.54675833,"gain of function"]
["p.Thr357Ser",1.856794625,8.88e-16,-0.912497582,0.912497582,"gain of function"]
["p.Thr420His",3.73e-13,2.08e-25,-0.646215525,0.646215525,"gain of function"]
["p.Thr420Ile",3.48e-08,7.84e-16,-0.720536739,0.720536739,"gain of function"]
["p.Thr420Leu",2.42e-50,4.2e-98,-0.6500557300000001,0.6500557300000001,"gain of function"]
["p.Thr420Trp",2.65e-60,1.25e-117,-0.715833286,0.715833286,"gain of function"]
["p.Thr420Val",5.27e-20,1.03e-38,-0.880492641,0.880492641,"gain of function"]
["p.Thr443Arg",6.45e-18,1.21e-34,-0.668128778,0.668128778,"gain of function"]
["p.Thr443Gln",1.94e-30,4.11e-59,-0.694208441,0.694208441,"gain of function"]
["p.Thr443Leu",1.27e-25,1.12e-49,-1.342419892,1.342419892,"gain of function"]
["p.Thr443Met",1.56e-09,2.07e-18,-1.645072633,1.645072633,"gain of function"]
["p.Thr443Trp",9.239999999999999e-47,4.37e-91,-0.7352038,0.7352038,"gain of function"]
["p.Thr443Tyr",1.48e-34,3.68e-67,-1.26703406,1.26703406,"gain of function"]
["p.Thr443Val",1.51e-31,2.88e-61,-1.362333371,1.362333371,"gain of function"]
["p.Thr460His",1.03e-05,3.69e-11,-0.892732324,0.892732324,"gain of function"]
["p.Thr460Tyr",0.992714062,3.33e-16,-0.939395438,0.939395438,"gain of function"]
["p.Thr511Asn",1.49e-09,1.92e-18,-1.327752488,1.327752488,"gain of function"]
["p.Thr511Asp",2.51e-26,4.66e-51,-1.401798059,1.401798059,"gain of function"]
["p.Thr511Glu",1.65e-78,2.51e-153,-0.89035721,0.89035721,"gain of function"]
["p.Thr511Gly",1.45e-63,5.09e-124,-0.940756705,0.940756705,"gain of function"]
["p.Thr511His",1.27e-16,4.11e-32,-1.366277132,1.366277132,"gain of function"]
["p.Thr511Ile",1.31e-36,3.45e-71,-0.657070514,0.657070514,"gain of function"]
["p.Thr511Phe",5.31e-07,1.42e-13,-0.706168508,0.706168508,"gain of function"]
["p.Thr511Pro",8.04e-81,7.56e-158,-1.070060896,1.070060896,"gain of function"]
["p.Thr511Trp",1.68e-42,9.59e-83,-1.098124289,1.098124289,"gain of function"]
["p.Thr511Tyr",4.56e-63,4.69e-123,-0.9515184,0.9515184,"gain of function"]
["p.Thr511Val",2.69e-59,1.16e-115,-0.68915639,0.68915639,"gain of function"]
["p.Trp285Ala",8.78e-31,9.27e-60,-2.296786597,2.296786597,"gain of function"]
["p.Trp285Arg",6.61e-10,4.39e-19,-3.221124489,3.221124489,"gain of function"]
["p.Trp285Asn",9.169999999999999e-24,5.05e-46,-3.835744845,3.835744845,"gain of function"]
["p.Trp285Asp",1.04e-19,3.83e-38,-0.967638314,0.967638314,"gain of function"]
["p.Trp285Cys",1.72e-35,5.68e-69,-2.60320004,2.60320004,"gain of function"]
["p.Trp285Glu",5.89e-33,5.05e-64,-1.294484315,1.294484315,"gain of function"]
["p.Trp285Gly",4.87e-08,1.51e-15,-1.401669445,1.401669445,"gain of function"]
["p.Trp285His",2.61e-63,1.64e-123,-1.861503446,1.861503446,"gain of function"]
["p.Trp285Ile",4.19e-25,1.21e-48,-2.488207521,2.488207521,"gain of function"]
["p.Trp285Leu",3.24e-34,1.75e-66,-2.16537328,2.16537328,"gain of function"]
["p.Trp285Met",4.85e-45,1.11e-87,-3.060304226,3.060304226,"gain of function"]
["p.Trp285Phe",6.09e-17,9.940000000000001e-33,-0.721692017,0.721692017,"gain of function"]
["p.Trp285Ser",2.26e-10,5.65e-20,-2.047980907,2.047980907,"gain of function"]
["p.Trp285Thr",3.36e-17,3.29e-33,-5.125043233,5.125043233,"gain of function"]
["p.Trp285Tyr",1.19e-12,2.13e-24,-2.398624254,2.398624254,"gain of function"]
["p.Trp285Val",7.730000000000001e-24,3.67e-46,-3.612409151,3.612409151,"gain of function"]
["p.Trp289Arg",8.55e-16,1.68e-30,-0.748248714,0.748248714,"gain of function"]
["p.Trp289Asn",0.691077234,1.2e-10,-0.658486852,0.658486852,"gain of function"]
["p.Trp289Asp",1.1e-06,5.04e-13,-0.798249721,0.798249721,"gain of function"]
["p.Trp289Cys",3.37e-09,9.84e-18,-1.297608905,1.297608905,"gain of function"]
["p.Trp289Gln",1.95e-61,7.69e-120,-0.9550372539999999,0.9550372539999999,"gain of function"]
["p.Trp289Glu",1.84e-28,3.18e-55,-1.116238529,1.116238529,"gain of function"]
["p.Trp289His",2.59e-12,9.89e-24,-1.176219518,1.176219518,"gain of function"]
["p.Trp289Ile",2.8e-10,7.53e-20,-0.6868535099999999,0.6868535099999999,"gain of function"]
["p.Trp289Lys",1.5e-26,1.74e-51,-2.197690221,2.197690221,"gain of function"]
["p.Trp289Thr",1.25e-06,6.82e-13,-0.771776343,0.771776343,"gain of function"]
["p.Trp289Val",1.36e-10,1.97e-20,-0.769790028,0.769790028,"gain of function"]
["p.Tyr329Arg",3.77e-29,1.47e-56,-1.994826388,1.994826388,"gain of function"]
["p.Tyr329Ile",1.03e-17,3.19e-34,-1.588378434,1.588378434,"gain of function"]
["p.Tyr338Leu",0.296981494,0.000565919,-1.730569868,1.730569868,"gain of function"]
["p.Tyr343Arg",1.83e-10,3.69e-20,-2.341061495,2.341061495,"gain of function"]
["p.Tyr385Ile",1.08e-33,1.86e-65,-1.770558074,1.770558074,"gain of function"]
["p.Tyr385Val",9.590000000000001e-07,4.37e-13,-1.765844334,1.765844334,"gain of function"]
["p.Tyr514Arg",3.36e-57,1.56e-111,-1.65915136,1.65915136,"gain of function"]
["p.Val274Ala",1.42e-63,5.01e-124,-1.913071123,1.913071123,"gain of function"]
["p.Val274Arg",3.85e-18,4.71e-35,-1.425989242,1.425989242,"gain of function"]
["p.Val274Asn",3.36e-05,3.26e-10,-0.837050908,0.837050908,"gain of function"]
["p.Val274Asp",9.26e-28,7.500000000000001e-54,-0.780821915,0.780821915,"gain of function"]
["p.Val274Cys",9.78e-36,1.86e-69,-2.88148288,2.88148288,"gain of function"]
["p.Val274Gly",3.3e-23,6.23e-45,-4.551151345,4.551151345,"gain of function"]
["p.Val274Met",1.46e-26,1.67e-51,-1.276818293,1.276818293,"gain of function"]
["p.Val274Pro",8.83e-53,7.5e-103,-2.92269163,2.92269163,"gain of function"]
["p.Val274Ser",2.84e-16,2.01e-31,-2.445162676,2.445162676,"gain of function"]
["p.Val274Thr",4.48e-45,8.970000000000001e-88,-1.125598312,1.125598312,"gain of function"]
["p.Val274Trp",1.61e-37,6.01e-73,-2.977879804,2.977879804,"gain of function"]
["p.Val316Ile",0.097782112,8.03e-10,-0.777365761,0.777365761,"gain of function"]
["p.Val326Arg",5.09e-54,2.7e-105,-2.512498332,2.512498332,"gain of function"]
["p.Val326Asn",5.29e-16,6.29e-31,-1.023287283,1.023287283,"gain of function"]
["p.Val331Cys",2.88e-54,8.67e-106,-0.946973549,0.946973549,"gain of function"]
["p.Val331Met",3.93e-18,4.88e-35,-1.398137445,1.398137445,"gain of function"]
["p.Val367Arg",7.97e-22,2.85e-42,-0.862834717,0.862834717,"gain of function"]
["p.Val367His",0.624206143,2.39e-06,-0.679754364,0.679754364,"gain of function"]
["p.Val380Met",4.55e-56,2.58e-109,-1.222339939,1.222339939,"gain of function"]
["p.Val380Trp",6.32e-37,8.48e-72,-1.320644725,1.320644725,"gain of function"]
["p.Val386Ile",1.67e-16,6.92e-32,-1.087878102,1.087878102,"gain of function"]
["p.Val402His",1.205253356,0,-1.033920714,1.033920714,"gain of function"]
["p.Val448Ile",1.39e-41,6.3e-81,-0.67989383,0.67989383,"gain of function"]
["p.Val464His",1.06e-12,1.69e-24,-0.93051678,0.93051678,"gain of function"]
["p.Val464Ser",8.61e-36,1.41e-69,-0.873465495,0.873465495,"gain of function"]
["p.Val464Thr",3.89e-28,1.36e-54,-0.994031125,0.994031125,"gain of function"]
["p.Val470Asp",7.61e-15,1.18e-28,-0.750558864,0.750558864,"gain of function"]
["p.Val470Gly",6.31e-95,1.68e-185,-1.597872739,1.597872739,"gain of function"]
["p.Val470Ser",6.93e-11,5.31e-21,-1.178356187,1.178356187,"gain of function"]
["p.Val478Ile",1.61e-18,8.18e-36,-0.6575943909999999,0.6575943909999999,"gain of function"]
["p.Val478Thr",0.003724254,6.54e-07,-0.674159733,0.674159733,"gain of function"]
["p.Ala296Arg",1.77e-11,3.74e-22,1.445753781,-1.445753781,"loss of function"]
["p.Ala296Asn",0.328239716,2.98e-06,1.922717041,-1.922717041,"loss of function"]
["p.Ala296Asp",1.31e-23,9.57e-46,1.588210927,-1.588210927,"loss of function"]
["p.Ala296Glu",9.650000000000001e-07,3.94e-13,1.602230795,-1.602230795,"loss of function"]
["p.Ala296Gly",4.61e-15,4.14e-29,1.130345238,-1.130345238,"loss of function"]
["p.Ala296Ile",0.418453842,9.24e-09,1.651312497,-1.651312497,"loss of function"]
["p.Ala296Leu",7.619999999999999e-08,3.37e-15,1.569647269,-1.569647269,"loss of function"]
["p.Ala296Phe",5.71e-10,2.99e-19,1.603328766,-1.603328766,"loss of function"]
["p.Ala296Ser",1.14e-44,5.49e-87,1.078247456,-1.078247456,"loss of function"]
["p.Ala296Ter",2.2e-23,2.63e-45,1.683328031,-1.683328031,"loss of function"]
["p.Ala296Val",2.53e-10,6.28e-20,1.398578806,-1.398578806,"loss of function"]
["p.Ala314Arg",5.1e-06,8.870000000000001e-12,1.445680807,-1.445680807,"loss of function"]
["p.Ala314Asn",2.02e-05,1.1e-10,1.537307771,-1.537307771,"loss of function"]
["p.Ala314Asp",2.01e-05,1.1e-10,1.516050273,-1.516050273,"loss of function"]
["p.Ala314Cys",6.94e-15,9.490000000000001e-29,1.034602091,-1.034602091,"loss of function"]
["p.Ala314Glu",0.345484982,3.44e-07,1.471321868,-1.471321868,"loss of function"]
["p.Ala314His",3.56e-05,3.08e-10,1.519716315,-1.519716315,"loss of function"]
["p.Ala314Ile",2.5e-12,8.55e-24,1.34064385,-1.34064385,"loss of function"]
["p.Ala314Leu",1.46e-09,1.82e-18,1.502737847,-1.502737847,"loss of function"]
["p.Ala314Lys",1.42e-13,3.32e-26,1.435325935,-1.435325935,"loss of function"]
["p.Ala314Met",8.51e-07,3.16e-13,1.519701388,-1.519701388,"loss of function"]
["p.Ala314Phe",1.88e-05,9.46e-11,1.599955049,-1.599955049,"loss of function"]
["p.Ala314Pro",1.5e-11,2.72e-22,1.460901592,-1.460901592,"loss of function"]
["p.Ala314Ser",8.77e-09,5.36e-17,0.792996579,-0.792996579,"loss of function"]
["p.Ala314Ter",6.96e-08,2.86e-15,1.613418417,-1.613418417,"loss of function"]
["p.Ala314Thr",3.28e-10,1.03e-19,1.460767563,-1.460767563,"loss of function"]
["p.Ala314Tyr",7.02e-09,3.61e-17,1.454942149,-1.454942149,"loss of function"]
["p.Ala314Val",4.33e-18,5.580000000000001e-35,1.273384549,-1.273384549,"loss of function"]
["p.Ala330Asp",2.1e-10,4.35e-20,1.362273835,-1.362273835,"loss of function"]
["p.Ala330Glu",0.000127896,2.98e-09,1.491390532,-1.491390532,"loss of function"]
["p.Ala330Gly",1.51e-81,2.75e-159,0.751840784,-0.751840784,"loss of function"]
["p.Ala330Ile",5.14e-17,7.01e-33,1.088310008,-1.088310008,"loss of function"]
["p.Ala330Leu",0.318622618,1.2e-05,1.487236757,-1.487236757,"loss of function"]
["p.Ala330Met",3.85e-15,3.01e-29,0.766481964,-0.766481964,"loss of function"]
["p.Ala330Pro",2.32e-05,1.38e-10,1.487787651,-1.487787651,"loss of function"]
["p.Ala330Val",4.71e-07,1.03e-13,1.151060608,-1.151060608,"loss of function"]
["p.Ala370Arg",1.48e-10,2.22e-20,1.533855375,-1.533855375,"loss of function"]
["p.Ala370Asn",2.65e-18,2.15e-35,1.178047822,-1.178047822,"loss of function"]
["p.Ala370Asp",3.35e-05,2.8e-10,1.514492736,-1.514492736,"loss of function"]
["p.Ala370Gln",4.67e-24,1.24e-46,0.780373093,-0.780373093,"loss of function"]
["p.Ala370Glu",3.66e-10,1.25e-19,1.193538073,-1.193538073,"loss of function"]
["p.Ala370His",8.5e-13,1.06e-24,1.550962299,-1.550962299,"loss of function"]
["p.Ala370Lys",2.34e-12,7.46e-24,1.495586939,-1.495586939,"loss of function"]
["p.Ala370Phe",1.68e-09,2.36e-18,1.468131332,-1.468131332,"loss of function"]
["p.Ala370Pro",0.000281677,1.11e-08,1.175347422,-1.175347422,"loss of function"]
["p.Ala370Ter",0.0009353159999999999,8.059999999999999e-08,1.605431018,-1.605431018,"loss of function"]
["p.Ala370Thr",0.392268127,8.330000000000001e-17,0.755402845,-0.755402845,"loss of function"]
["p.Ala370Tyr",3.45e-10,1.13e-19,1.638893403,-1.638893403,"loss of function"]
["p.Ala371Cys",8.33e-08,3.91e-15,0.587725504,-0.587725504,"loss of function"]
["p.Ala371Pro",3.16e-09,7.87e-18,1.228557593,-1.228557593,"loss of function"]
["p.Ala371Ter",2.95e-06,3.21e-12,1.547478551,-1.547478551,"loss of function"]
["p.Ala374Arg",1.37e-13,3.13e-26,1.545323634,-1.545323634,"loss of function"]
["p.Ala374Asn",0.201153528,0.000152108,0.71527318,-0.71527318,"loss of function"]
["p.Ala374Asp",0.305388039,0.000422352,1.665487134,-1.665487134,"loss of function"]
["p.Ala374Gln",0.045810018,0.000124025,1.556677071,-1.556677071,"loss of function"]
["p.Ala374Gly",0.000604536,3.32e-08,0.78879845,-0.78879845,"loss of function"]
["p.Ala374Lys",0.039751371,8.18e-05,1.778228513,-1.778228513,"loss of function"]
["p.Ala374Met",4.36e-27,1.48e-52,0.609234241,-0.609234241,"loss of function"]
["p.Ala374Phe",4.72e-22,1.03e-42,1.245313789,-1.245313789,"loss of function"]
["p.Ala374Pro",1.09e-10,1.21e-20,1.543175733,-1.543175733,"loss of function"]
["p.Ala374Ter",8.55e-09,5.35e-17,1.634298785,-1.634298785,"loss of function"]
["p.Ala374Tyr",6.39e-44,1.62e-85,1.601380844,-1.601380844,"loss of function"]
["p.Ala378Pro",8.98e-06,2.49e-11,1.656634296,-1.656634296,"loss of function"]
["p.Ala392Ile",1.01e-08,6.76e-17,0.5728470879999999,-0.5728470879999999,"loss of function"]
["p.Ala392Pro",0.004581818,4.87e-07,1.514189582,-1.514189582,"loss of function"]
["p.Ala393Arg",0.020079003,1.43e-05,1.45672748,-1.45672748,"loss of function"]
["p.Ala393Cys",0.253841851,3.05e-11,0.559561235,-0.559561235,"loss of function"]
["p.Ala393Gln",2.02e-08,2.56e-16,0.806202867,-0.806202867,"loss of function"]
["p.Ala393Gly",3.34e-24,6.51e-47,0.902096046,-0.902096046,"loss of function"]
["p.Ala393Ile",1.62e-15,5.6e-30,1.029916706,-1.029916706,"loss of function"]
["p.Ala393Leu",2.07e-15,9.199999999999999e-30,1.46221113,-1.46221113,"loss of function"]
["p.Ala393Lys",0.009768555999999999,8.09e-07,1.411793603,-1.411793603,"loss of function"]
["p.Ala393Phe",7.67e-09,4.31e-17,1.577036393,-1.577036393,"loss of function"]
["p.Ala393Pro",5.57e-16,7.12e-31,1.097335663,-1.097335663,"loss of function"]
["p.Ala393Ser",0.212237968,6.31e-16,0.494278631,-0.494278631,"loss of function"]
["p.Ala406Arg",1.04e-15,2.41e-30,1.624014961,-1.624014961,"loss of function"]
["p.Ala406Asn",7.79e-08,3.51e-15,1.36242443,-1.36242443,"loss of function"]
["p.Ala406Asp",4.66e-14,3.83e-27,1.379233067,-1.379233067,"loss of function"]
["p.Ala406Glu",2.5e-05,1.62e-10,1.52039556,-1.52039556,"loss of function"]
["p.Ala406Ile",0.369899387,5.05e-07,1.605894644,-1.605894644,"loss of function"]
["p.Ala406Leu",1.65e-17,7.66e-34,1.455140026,-1.455140026,"loss of function"]
["p.Ala406Lys",2.82e-13,1.26e-25,1.551386644,-1.551386644,"loss of function"]
["p.Ala406Pro",9.59e-11,9.63e-21,1.568783885,-1.568783885,"loss of function"]
["p.Ala406Ser",4.11e-15,3.4e-29,0.75479012,-0.75479012,"loss of function"]
["p.Ala406Ter",1.15e-11,1.63e-22,1.711585872,-1.711585872,"loss of function"]
["p.Ala406Thr",0.15058099,0.001367859,1.459540653,-1.459540653,"loss of function"]
["p.Ala406Tyr",6.51e-09,3.16e-17,1.589791524,-1.589791524,"loss of function"]
["p.Ala406Val",3.14e-09,7.88e-18,1.486905325,-1.486905325,"loss of function"]
["p.Ala411Arg",5.73e-10,3.02e-19,1.60583874,-1.60583874,"loss of function"]
["p.Ala411Asn",2.38e-09,4.54e-18,2.054579604,-2.054579604,"loss of function"]
["p.Ala411Asp",0.000275854,1.11e-08,1.559698331,-1.559698331,"loss of function"]
["p.Ala411Gln",4e-08,9.899999999999999e-16,1.64321843,-1.64321843,"loss of function"]
["p.Ala411Glu",7.99e-06,2.05e-11,1.648558758,-1.648558758,"loss of function"]
["p.Ala411Gly",6.42e-10,3.76e-19,1.519354763,-1.519354763,"loss of function"]
["p.Ala411His",9.98e-21,4.05e-40,1.520313673,-1.520313673,"loss of function"]
["p.Ala411Ile",1.97e-14,7.19e-28,1.676692875,-1.676692875,"loss of function"]
["p.Ala411Leu",6.790000000000001e-08,2.71e-15,1.505489323,-1.505489323,"loss of function"]
["p.Ala411Met",9.21e-18,2.33e-34,1.116106248,-1.116106248,"loss of function"]
["p.Ala411Ser",1.27e-31,1.98e-61,0.979248569,-0.979248569,"loss of function"]
["p.Ala411Ter",1.87e-33,5.23e-65,1.278705315,-1.278705315,"loss of function"]
["p.Ala411Thr",9.21e-27,6.39e-52,0.704363901,-0.704363901,"loss of function"]
["p.Ala411Tyr",8.02e-08,3.76e-15,1.652547624,-1.652547624,"loss of function"]
["p.Ala411Val",8.53e-13,1.07e-24,1.363482626,-1.363482626,"loss of function"]
["p.Ala421Arg",9.360000000000001e-10,7.73e-19,1.462328957,-1.462328957,"loss of function"]
["p.Ala421Asn",9.17e-15,1.63e-28,1.383495092,-1.383495092,"loss of function"]
["p.Ala421Asp",1.25e-10,1.61e-20,1.443087174,-1.443087174,"loss of function"]
["p.Ala421Gln",1.72e-29,3e-57,1.17713167,-1.17713167,"loss of function"]
["p.Ala421Glu",1.42e-15,4.4e-30,1.440735133,-1.440735133,"loss of function"]
["p.Ala421Gly",1.52e-25,1.56e-49,1.154671398,-1.154671398,"loss of function"]
["p.Ala421His",2.02e-06,1.58e-12,1.558192061,-1.558192061,"loss of function"]
["p.Ala421Ile",5.04e-30,2.69e-58,1.122944123,-1.122944123,"loss of function"]
["p.Ala421Leu",7.67e-18,1.7e-34,1.181767734,-1.181767734,"loss of function"]
["p.Ala421Lys",5.65e-13,4.8e-25,1.469281239,-1.469281239,"loss of function"]
["p.Ala421Met",8.6e-20,2.62e-38,0.539124178,-0.539124178,"loss of function"]
["p.Ala421Phe",8.120000000000001e-17,1.68e-32,1.338373885,-1.338373885,"loss of function"]
["p.Ala421Pro",1.17e-13,2.24e-26,0.979404691,-0.979404691,"loss of function"]
["p.Ala421Ser",7.510000000000001e-26,3.93e-50,1.028266076,-1.028266076,"loss of function"]
["p.Ala421Ter",6.32e-07,1.8e-13,1.762278082,-1.762278082,"loss of function"]
["p.Ala421Thr",8.85e-10,6.96e-19,1.288147148,-1.288147148,"loss of function"]
["p.Ala421Trp",3.98e-26,1.15e-50,1.293835709,-1.293835709,"loss of function"]
["p.Ala421Tyr",1.04e-09,9.369999999999999e-19,1.448693728,-1.448693728,"loss of function"]
["p.Ala421Val",7.37e-35,9.12e-68,0.881178188,-0.881178188,"loss of function"]
["p.Ala425Arg",5.62e-18,9.22e-35,1.33755062,-1.33755062,"loss of function"]
["p.Ala425Asn",4.68e-41,6.67e-80,1.011444943,-1.011444943,"loss of function"]
["p.Ala425Asp",1.32e-09,1.44e-18,0.771973196,-0.771973196,"loss of function"]
["p.Ala425Cys",8.69e-16,1.56e-30,0.502230292,-0.502230292,"loss of function"]
["p.Ala425Gln",9.06e-10,7.04e-19,0.711008432,-0.711008432,"loss of function"]
["p.Ala425Glu",6.9e-13,7.1e-25,1.151027837,-1.151027837,"loss of function"]
["p.Ala425His",3.73e-28,1.24e-54,1.293002237,-1.293002237,"loss of function"]
["p.Ala425Ile",2.15e-34,7.6e-67,1.232646263,-1.232646263,"loss of function"]
["p.Ala425Leu",1.43e-33,3.09e-65,1.067984601,-1.067984601,"loss of function"]
["p.Ala425Lys",2.1e-18,1.36e-35,1.181250205,-1.181250205,"loss of function"]
["p.Ala425Met",1.91e-57,4.97e-112,0.806155396,-0.806155396,"loss of function"]
["p.Ala425Pro",0.001000667,8.940000000000001e-08,1.561130608,-1.561130608,"loss of function"]
["p.Ala425Ter",0.002967884,3.75e-07,1.61507122,-1.61507122,"loss of function"]
["p.Ala425Trp",1.99e-10,3.93e-20,1.337100204,-1.337100204,"loss of function"]
["p.Ala425Tyr",1.78e-25,2.14e-49,1.04327467,-1.04327467,"loss of function"]
["p.Ala425Val",2.81e-31,9.49e-61,1.190927397,-1.190927397,"loss of function"]
["p.Ala433Arg",4.96e-12,3.23e-23,1.534817995,-1.534817995,"loss of function"]
["p.Ala433Asn",1.59e-12,3.6e-24,1.589291042,-1.589291042,"loss of function"]
["p.Ala433Gln",6.83e-14,8.070000000000001e-27,1.601065361,-1.601065361,"loss of function"]
["p.Ala433His",1.8e-12,4.54e-24,1.568750299,-1.568750299,"loss of function"]
["p.Ala433Ile",1.31e-11,2.09e-22,1.635464004,-1.635464004,"loss of function"]
["p.Ala433Leu",2.73e-12,1.02e-23,1.574300929,-1.574300929,"loss of function"]
["p.Ala433Lys",1.09e-14,2.3e-28,1.566627877,-1.566627877,"loss of function"]
["p.Ala433Met",2.55e-10,6.35e-20,1.582557372,-1.582557372,"loss of function"]
["p.Ala433Phe",1.56e-11,2.93e-22,1.495173602,-1.495173602,"loss of function"]
["p.Ala433Ter",3.77e-12,1.89e-23,1.591552369,-1.591552369,"loss of function"]
["p.Ala433Thr",4.96e-14,4.35e-27,1.417597647,-1.417597647,"loss of function"]
["p.Ala433Trp",1.59e-11,3.06e-22,1.571722926,-1.571722926,"loss of function"]
["p.Ala433Tyr",1.05e-21,5.01e-42,1.474170103,-1.474170103,"loss of function"]
["p.Ala433Val",1.76e-09,2.57e-18,1.624442533,-1.624442533,"loss of function"]
["p.Ala436Val",0.013007362,1.77e-06,1.13024783,-1.13024783,"loss of function"]
["p.Ala437Arg",2.31e-21,2.35e-41,1.510047172,-1.510047172,"loss of function"]
["p.Ala437Cys",3.58e-06,4.06e-12,0.575110984,-0.575110984,"loss of function"]
["p.Ala437Ile",3.6e-89,3.03e-174,0.705002935,-0.705002935,"loss of function"]
["p.Ala437Leu",5.9e-19,1.15e-36,0.936069784,-0.936069784,"loss of function"]
["p.Ala437Lys",0.000296025,1.28e-08,1.333604521,-1.333604521,"loss of function"]
["p.Ala437Thr",6.48e-23,2.14e-44,1.081169168,-1.081169168,"loss of function"]
["p.Ala437Val",1.95e-19,1.34e-37,1.012076144,-1.012076144,"loss of function"]
["p.Arg271Pro",0.299599986,2.73e-06,0.5453706149999999,-0.5453706149999999,"loss of function"]
["p.Arg271Thr",8.18e-20,2.44e-38,1.531695125,-1.531695125,"loss of function"]
["p.Arg271Tyr",0.293273715,0,0.704452074,-0.704452074,"loss of function"]
["p.Arg294Ter",9.81e-09,6.84e-17,1.568246818,-1.568246818,"loss of function"]
["p.Arg321Leu",5.92e-26,2.46e-50,0.516536113,-0.516536113,"loss of function"]
["p.Arg321Pro",0.189136286,2.4e-14,0.493109791,-0.493109791,"loss of function"]
["p.Arg362Ala",9.4e-12,1.07e-22,0.660040838,-0.660040838,"loss of function"]
["p.Arg362Asn",1.87e-18,1.09e-35,0.611584752,-0.611584752,"loss of function"]
["p.Arg362Asp",9.07e-20,2.96e-38,0.90308154,-0.90308154,"loss of function"]
["p.Arg362Glu",2.39e-14,1.03e-27,0.927346035,-0.927346035,"loss of function"]
["p.Arg362Gly",0.0009888119999999999,6.94e-08,0.6216350309999999,-0.6216350309999999,"loss of function"]
["p.Arg362His",1.88e-19,1.19e-37,0.526139424,-0.526139424,"loss of function"]
["p.Arg362Ile",0.316961325,6.94e-17,0.574875284,-0.574875284,"loss of function"]
["p.Arg362Leu",2.1e-09,3.39e-18,0.499534301,-0.499534301,"loss of function"]
["p.Arg362Pro",1.5e-50,1.67e-98,0.811061837,-0.811061837,"loss of function"]
["p.Arg362Ser",4.36e-11,2.08e-21,0.640640329,-0.640640329,"loss of function"]
["p.Arg362Ter",4.96e-10,2.26e-19,1.655836322,-1.655836322,"loss of function"]
["p.Arg362Thr",3.6e-06,4.45e-12,0.844740317,-0.844740317,"loss of function"]
["p.Arg362Val",3.96e-24,9.150000000000001e-47,0.659708302,-0.659708302,"loss of function"]
["p.Arg382Pro",0.000996315,8.39e-08,1.472081063,-1.472081063,"loss of function"]
["p.Arg388Asn",5.32e-14,4.9e-27,1.169262798,-1.169262798,"loss of function"]
["p.Arg388Asp",1.97e-05,1.07e-10,1.651676681,-1.651676681,"loss of function"]
["p.Arg388Gln",6.43e-27,3.26e-52,1.579661303,-1.579661303,"loss of function"]
["p.Arg388Gly",1.86e-11,4.12e-22,1.770053668,-1.770053668,"loss of function"]
["p.Arg388His",0.002907553,3.55e-07,1.545293729,-1.545293729,"loss of function"]
["p.Arg388Ile",6.55e-08,2.43e-15,0.651445885,-0.651445885,"loss of function"]
["p.Arg388Leu",7.709999999999999e-09,4.36e-17,1.51130375,-1.51130375,"loss of function"]
["p.Arg388Phe",3.52e-18,3.82e-35,1.450174255,-1.450174255,"loss of function"]
["p.Arg388Pro",3.42e-08,7.44e-16,1.483734649,-1.483734649,"loss of function"]
["p.Arg388Ser",2.21e-10,4.82e-20,1.481842665,-1.481842665,"loss of function"]
["p.Arg388Thr",5.49e-15,6.120000000000001e-29,1.541849959,-1.541849959,"loss of function"]
["p.Arg388Tyr",6.950000000000001e-11,5.19e-21,1.552100263,-1.552100263,"loss of function"]
["p.Arg391Ala",6.57e-12,5.53e-23,1.510186971,-1.510186971,"loss of function"]
["p.Arg391Asn",6.93e-12,6.11e-23,1.508504128,-1.508504128,"loss of function"]
["p.Arg391Asp",9.889999999999999e-13,1.43e-24,1.575992162,-1.575992162,"loss of function"]
["p.Arg391Cys",6.05e-10,3.34e-19,1.477636372,-1.477636372,"loss of function"]
["p.Arg391Gln",0.000234111,7.769999999999999e-09,1.880901955,-1.880901955,"loss of function"]
["p.Arg391Glu",7.89e-12,7.9e-23,1.460301081,-1.460301081,"loss of function"]
["p.Arg391Gly",1.23e-18,4.86e-36,1.547641074,-1.547641074,"loss of function"]
["p.Arg391His",6.46e-07,1.92e-13,1.511786085,-1.511786085,"loss of function"]
["p.Arg391Ile",2.59e-07,3.35e-14,1.639698651,-1.639698651,"loss of function"]
["p.Arg391Leu",2.48e-09,4.95e-18,1.63877344,-1.63877344,"loss of function"]
["p.Arg391Lys",5.59e-09,2.34e-17,1.304469053,-1.304469053,"loss of function"]
["p.Arg391Phe",1.59e-20,1.01e-39,1.396896391,-1.396896391,"loss of function"]
["p.Arg391Pro",3.23e-11,1.19e-21,1.589969979,-1.589969979,"loss of function"]
["p.Arg391Ser",7.09e-07,2.23e-13,1.571482272,-1.571482272,"loss of function"]
["p.Arg391Thr",0.000174851,5.11e-09,1.502866529,-1.502866529,"loss of function"]
["p.Arg391Tyr",7.26e-07,2.35e-13,1.532677651,-1.532677651,"loss of function"]
["p.Arg391Val",0.269491175,8.059999999999999e-05,1.607396576,-1.607396576,"loss of function"]
["p.Arg412Ala",5.18e-07,1.25e-13,1.545402765,-1.545402765,"loss of function"]
["p.Arg412Asn",7.55e-06,1.85e-11,1.429842262,-1.429842262,"loss of function"]
["p.Arg412Asp",1.69e-07,1.51e-14,1.504452464,-1.504452464,"loss of function"]
["p.Arg412Cys",6.93e-13,7.09e-25,1.529488703,-1.529488703,"loss of function"]
["p.Arg412Gln",7.07e-06,1.64e-11,1.252943383,-1.252943383,"loss of function"]
["p.Arg412Glu",4.19e-12,2.3e-23,1.525404768,-1.525404768,"loss of function"]
["p.Arg412Gly",8.129999999999999e-08,3.83e-15,1.53044378,-1.53044378,"loss of function"]
["p.Arg412His",0.268206484,1.42e-05,1.780599716,-1.780599716,"loss of function"]
["p.Arg412Leu",4.49e-10,1.87e-19,1.312008844,-1.312008844,"loss of function"]
["p.Arg412Phe",9.280000000000001e-13,1.26e-24,1.381415906,-1.381415906,"loss of function"]
["p.Arg412Pro",1.87e-05,9.53e-11,1.637693622,-1.637693622,"loss of function"]
["p.Arg412Ter",1.55e-09,2.02e-18,1.617167761,-1.617167761,"loss of function"]
["p.Arg412Thr",5.44e-47,1.58e-91,1.015541835,-1.015541835,"loss of function"]
["p.Arg412Trp",9.3e-15,1.7e-28,1.571657409,-1.571657409,"loss of function"]
["p.Arg412Tyr",5.12e-11,2.91e-21,1.505652504,-1.505652504,"loss of function"]
["p.Arg412Val",3.81e-26,1.05e-50,1.254735855,-1.254735855,"loss of function"]
["p.Arg422Ala",7.87e-30,6.22e-58,0.570675975,-0.570675975,"loss of function"]
["p.Arg422Asp",6.77e-25,2.87e-48,0.693167464,-0.693167464,"loss of function"]
["p.Arg422Gln",2.32e-05,1.21e-10,0.511432237,-0.511432237,"loss of function"]
["p.Arg422Glu",1.01e-30,1.14e-59,0.478966556,-0.478966556,"loss of function"]
["p.Arg422Ile",1.4e-47,1.08e-92,1.022169145,-1.022169145,"loss of function"]
["p.Arg422Leu",1.72e-48,1.78e-94,0.906785188,-0.906785188,"loss of function"]
["p.Arg422Met",4.45e-51,1.5e-99,0.777244651,-0.777244651,"loss of function"]
["p.Arg422Phe",2.92e-72,4.49e-141,1.111408807,-1.111408807,"loss of function"]
["p.Arg422Ter",0.023908285,2.13e-05,1.663449451,-1.663449451,"loss of function"]
["p.Arg422Trp",1.2e-28,1.32e-55,0.812430754,-0.812430754,"loss of function"]
["p.Arg422Tyr",6.14e-55,4.11e-107,0.90574953,-0.90574953,"loss of function"]
["p.Arg422Val",4.36e-48,1.11e-93,0.8192062369999999,-0.8192062369999999,"loss of function"]
["p.Arg441Ala",1.83e-15,6.959999999999999e-30,0.708846184,-0.708846184,"loss of function"]
["p.Arg441Asn",9.119999999999999e-44,3.26e-85,1.100674315,-1.100674315,"loss of function"]
["p.Arg441Asp",0.000346037,1.58e-08,1.601346453,-1.601346453,"loss of function"]
["p.Arg441Gln",8.89e-42,2.56e-81,0.7398442670000001,-0.7398442670000001,"loss of function"]
["p.Arg441Glu",1.61e-16,6.35e-32,1.227609566,-1.227609566,"loss of function"]
["p.Arg441Leu",1.2e-18,4.55e-36,1.104295989,-1.104295989,"loss of function"]
["p.Arg441Met",2.91e-65,2.34e-127,0.887410122,-0.887410122,"loss of function"]
["p.Arg441Phe",6.3e-79,3.81e-154,0.902962809,-0.902962809,"loss of function"]
["p.Arg441Pro",1.16e-15,2.91e-30,0.726792663,-0.726792663,"loss of function"]
["p.Arg441Ter",2.1e-11,5.24e-22,1.649876198,-1.649876198,"loss of function"]
["p.Arg441Trp",9.25e-40,2.34e-77,0.651276309,-0.651276309,"loss of function"]
["p.Arg441Tyr",1.91e-37,7.93e-73,0.6324530229999999,-0.6324530229999999,"loss of function"]
["p.Arg463Asp",9.26e-20,3.13e-38,1.36634269,-1.36634269,"loss of function"]
["p.Arg463Cys",8.02e-12,7.59e-23,0.467164754,-0.467164754,"loss of function"]
["p.Arg463Met",0.262617227,7.88e-12,0.581773117,-0.581773117,"loss of function"]
["p.Arg463Pro",1.08e-05,3.45e-11,1.718054435,-1.718054435,"loss of function"]
["p.Arg463Ter",9.45e-07,3.91e-13,1.677718103,-1.677718103,"loss of function"]
["p.Arg472Asp",2.37e-30,6.13e-59,0.958234762,-0.958234762,"loss of function"]
["p.Arg472Glu",3.78e-09,1.09e-17,1.253391624,-1.253391624,"loss of function"]
["p.Arg472Ile",0.619774185,0,0.566684907,-0.566684907,"loss of function"]
["p.Arg472Ter",0.000611585,4.07e-08,1.380309368,-1.380309368,"loss of function"]
["p.Arg480Asn",0.554727877,0,1.125249171,-1.125249171,"loss of function"]
["p.Arg480Pro",6.9e-17,1.22e-32,1.145401156,-1.145401156,"loss of function"]
["p.Arg480Ter",3.64e-09,1.04e-17,1.489057332,-1.489057332,"loss of function"]
["p.Arg483Ala",4.64e-28,1.88e-54,0.849314491,-0.849314491,"loss of function"]
["p.Arg483Asp",1.99e-08,2.63e-16,1.563211712,-1.563211712,"loss of function"]
["p.Arg483Glu",1.13e-20,5.11e-40,1.188601005,-1.188601005,"loss of function"]
["p.Arg483Gly",7.83e-15,1.22e-28,1.429780688,-1.429780688,"loss of function"]
["p.Arg483Pro",3.61e-12,1.74e-23,1.488462214,-1.488462214,"loss of function"]
["p.Arg483Ser",2.8e-27,6.26e-53,0.82804177,-0.82804177,"loss of function"]
["p.Arg483Ter",1.33e-13,2.93e-26,1.588086749,-1.588086749,"loss of function"]
["p.Arg483Trp",2.03e-89,1.02e-174,0.88755668,-0.88755668,"loss of function"]
["p.Arg503Pro",3.67e-53,1.25e-103,0.8100539919999999,-0.8100539919999999,"loss of function"]
["p.Arg503Ter",9.45e-11,9.46e-21,1.659572844,-1.659572844,"loss of function"]
["p.Arg509Ala",9.01e-10,7.21e-19,1.587450152,-1.587450152,"loss of function"]
["p.Arg509Asn",1.25e-07,8.56e-15,1.631159765,-1.631159765,"loss of function"]
["p.Arg509Asp",3.51e-15,2.57e-29,1.437106256,-1.437106256,"loss of function"]
["p.Arg509Cys",0.002774294,3.34e-07,1.554288866,-1.554288866,"loss of function"]
["p.Arg509Gln",5.92e-12,4.51e-23,1.718585597,-1.718585597,"loss of function"]
["p.Arg509Glu",1.04e-10,1.13e-20,1.600229056,-1.600229056,"loss of function"]
["p.Arg509Gly",2.76e-05,1.95e-10,1.616696763,-1.616696763,"loss of function"]
["p.Arg509His",4.52e-08,1.25e-15,1.585959926,-1.585959926,"loss of function"]
["p.Arg509Ile",1.86e-07,1.84e-14,1.51228924,-1.51228924,"loss of function"]
["p.Arg509Leu",8.19e-16,1.5e-30,1.567043559,-1.567043559,"loss of function"]
["p.Arg509Lys",5.54e-06,1.04e-11,1.611260485,-1.611260485,"loss of function"]
["p.Arg509Met",1.01e-08,7.219999999999999e-17,1.628555958,-1.628555958,"loss of function"]
["p.Arg509Phe",0.269077719,0.000323785,1.722014498,-1.722014498,"loss of function"]
["p.Arg509Pro",9.25e-09,6.18e-17,1.587071721,-1.587071721,"loss of function"]
["p.Arg509Ser",3.28e-11,1.23e-21,1.554135484,-1.554135484,"loss of function"]
["p.Arg509Ter",7.03e-13,7.42e-25,1.452863991,-1.452863991,"loss of function"]
["p.Arg509Thr",1.69e-08,1.94e-16,1.590854048,-1.590854048,"loss of function"]
["p.Arg509Trp",7.59e-18,1.69e-34,1.459140248,-1.459140248,"loss of function"]
["p.Arg509Tyr",0.264473711,0.000110336,1.647799956,-1.647799956,"loss of function"]
["p.Arg509Val",2.33e-06,2.08e-12,1.5897028,-1.5897028,"loss of function"]
["p.Asn290Lys",0.288181047,1.39e-17,0.466800783,-0.466800783,"loss of function"]
["p.Asn290Ter",6.29e-11,4.31e-21,1.587824122,-1.587824122,"loss of function"]
["p.Asn384Ala",0.5308723440000001,0,0.707501503,-0.707501503,"loss of function"]
["p.Asn384Asp",1.38e-09,1.6e-18,0.959415485,-0.959415485,"loss of function"]
["p.Asn384Glu",9.82e-26,6.71e-50,0.903909485,-0.903909485,"loss of function"]
["p.Asn384Ile",8.31e-20,2.46e-38,0.692677893,-0.692677893,"loss of function"]
["p.Asn384Ter",5.63e-13,4.82e-25,1.541408723,-1.541408723,"loss of function"]
["p.Asn384Val",1.040102753,2.22e-16,0.854199252,-0.854199252,"loss of function"]
["p.Asn394Ala",5.48e-12,3.91e-23,1.583857225,-1.583857225,"loss of function"]
["p.Asn394Arg",0.539667327,4.94e-09,1.786398423,-1.786398423,"loss of function"]
["p.Asn394Asp",0.489762802,1.62e-11,1.680941,-1.680941,"loss of function"]
["p.Asn394Cys",0.026495311,2.88e-05,1.67129949,-1.67129949,"loss of function"]
["p.Asn394Gln",2.54e-16,1.55e-31,1.391460199,-1.391460199,"loss of function"]
["p.Asn394Gly",0.352859608,5.83e-09,1.800608198,-1.800608198,"loss of function"]
["p.Asn394His",2.6e-21,2.93e-41,1.9669932,-1.9669932,"loss of function"]
["p.Asn394Ile",2.53e-05,1.65e-10,1.523601777,-1.523601777,"loss of function"]
["p.Asn394Leu",2.2e-05,1.29e-10,1.61829063,-1.61829063,"loss of function"]
["p.Asn394Met",2.4e-08,3.66e-16,1.616528245,-1.616528245,"loss of function"]
["p.Asn394Phe",0.4299815,1.33e-08,1.761168137,-1.761168137,"loss of function"]
["p.Asn394Pro",0.001396611,1.49e-07,1.593820634,-1.593820634,"loss of function"]
["p.Asn394Ser",0.001910217,2.09e-07,1.772539114,-1.772539114,"loss of function"]
["p.Asn394Tyr",1.29e-05,4.85e-11,1.584994718,-1.584994718,"loss of function"]
["p.Asn394Val",3.43e-16,2.78e-31,1.603436611,-1.603436611,"loss of function"]
["p.Asn417Ala",6.59e-10,3.92e-19,0.89987412,-0.89987412,"loss of function"]
["p.Asn417Arg",1.65e-33,4.06e-65,0.771352194,-0.771352194,"loss of function"]
["p.Asn417Cys",0.025022166,3.45e-05,0.493660091,-0.493660091,"loss of function"]
["p.Asn417Ile",2.73e-12,9.93e-24,1.152408366,-1.152408366,"loss of function"]
["p.Asn417Leu",8.32e-38,1.54e-73,0.883496697,-0.883496697,"loss of function"]
["p.Asn417Lys",4.22e-11,1.96e-21,0.874831864,-0.874831864,"loss of function"]
["p.Asn417Met",2.6e-11,7.3e-22,0.70336924,-0.70336924,"loss of function"]
["p.Asn417Pro",3.98e-10,1.49e-19,1.531914183,-1.531914183,"loss of function"]
["p.Asn417Ter",1.15e-11,1.61e-22,1.659110837,-1.659110837,"loss of function"]
["p.Asn471Ala",3.54e-16,2.92e-31,1.063258539,-1.063258539,"loss of function"]
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["p.Met305Leu",6.04e-09,2.7e-17,1.399531592,-1.399531592,"loss of function"]
["p.Met305Phe",3.68e-10,1.29e-19,1.552924631,-1.552924631,"loss of function"]
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["p.Met305Thr",0.390519734,8.4e-14,1.471547465,-1.471547465,"loss of function"]
["p.Met317Ala",1.86e-09,2.85e-18,1.422171715,-1.422171715,"loss of function"]
["p.Met317Arg",7.94e-16,1.43e-30,1.530304249,-1.530304249,"loss of function"]
["p.Met317Asn",7.699999999999999e-09,4.32e-17,0.996816458,-0.996816458,"loss of function"]
["p.Met317Asp",5.66e-05,7.01e-10,1.55969179,-1.55969179,"loss of function"]
["p.Met317Cys",0.000267684,1.03e-08,1.131939019,-1.131939019,"loss of function"]
["p.Met317Gln",1.57e-05,6.819999999999999e-11,1.392699921,-1.392699921,"loss of function"]
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["p.Met317His",2.16e-11,5.36e-22,0.608430587,-0.608430587,"loss of function"]
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["p.Met317Leu",3.09e-12,1.24e-23,0.47948261,-0.47948261,"loss of function"]
["p.Met317Lys",2.67e-14,1.31e-27,1.605228796,-1.605228796,"loss of function"]
["p.Met317Phe",1.31e-07,9.490000000000001e-15,1.534294186,-1.534294186,"loss of function"]
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["p.Met317Ser",3.86e-05,3.46e-10,1.166773128,-1.166773128,"loss of function"]
["p.Met317Ter",2.87e-10,8.030000000000001e-20,1.658190713,-1.658190713,"loss of function"]
["p.Met317Thr",2.21e-07,2.52e-14,1.524513444,-1.524513444,"loss of function"]
["p.Met317Trp",5.08e-21,1.09e-40,1.623778417,-1.623778417,"loss of function"]
["p.Met317Tyr",3.4e-08,7.22e-16,1.351531554,-1.351531554,"loss of function"]
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["p.Met344Asp",1.04e-24,6.74e-48,1.242310631,-1.242310631,"loss of function"]
["p.Met344Glu",0.114158088,2.03e-09,0.494881915,-0.494881915,"loss of function"]
["p.Met344Gly",2.85e-82,1.05e-160,1.076243885,-1.076243885,"loss of function"]
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["p.Met344Leu",2.76e-27,6.03e-53,0.875477153,-0.875477153,"loss of function"]
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["p.Met344Thr",7.4e-10,4.79e-19,1.334920877,-1.334920877,"loss of function"]
["p.Met344Trp",8.82e-10,6.81e-19,1.737964483,-1.737964483,"loss of function"]
["p.Met344Tyr",3.29e-38,2.47e-74,0.667031931,-0.667031931,"loss of function"]
["p.Met369Arg",9.55e-64,2.17e-124,1.10712812,-1.10712812,"loss of function"]
["p.Met369Pro",0.025114621,2.59e-05,1.439098799,-1.439098799,"loss of function"]
["p.Met369Ter",6.12e-07,1.72e-13,1.680086468,-1.680086468,"loss of function"]
["p.Met377Arg",1.56e-13,4.02e-26,1.550844652,-1.550844652,"loss of function"]
["p.Met377Asp",0.003524531,3.77e-07,1.656941853,-1.656941853,"loss of function"]
["p.Met377Gln",3.95e-45,6.98e-88,0.773227621,-0.773227621,"loss of function"]
["p.Met377Glu",0.012810943,1.02e-05,0.5876035120000001,-0.5876035120000001,"loss of function"]
["p.Met377Leu",6.39e-59,6.39e-115,0.734642152,-0.734642152,"loss of function"]
["p.Met377Lys",0.092670954,0.000627586,1.366239299,-1.366239299,"loss of function"]
["p.Met377Phe",0.000945518,6.879999999999999e-08,1.390475628,-1.390475628,"loss of function"]
["p.Met377Pro",3.78e-17,3.82e-33,1.505488096,-1.505488096,"loss of function"]
["p.Met377Tyr",3.55e-05,2.86e-10,0.803435335,-0.803435335,"loss of function"]
["p.Met383Ile",5.04e-09,1.9e-17,1.231975385,-1.231975385,"loss of function"]
["p.Met383Leu",8.989999999999999e-11,8.400000000000001e-21,1.183887901,-1.183887901,"loss of function"]
["p.Met383Pro",1.14e-07,7.239999999999999e-15,1.554404208,-1.554404208,"loss of function"]
["p.Met383Ser",3.53e-47,6.74e-92,0.908744666,-0.908744666,"loss of function"]
["p.Met383Tyr",1.2e-07,7.860000000000001e-15,1.011001315,-1.011001315,"loss of function"]
["p.Met383Val",6.74e-36,8.549999999999999e-70,0.949267139,-0.949267139,"loss of function"]
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["p.Met469Gly",4.1e-24,9.889999999999999e-47,1.202986584,-1.202986584,"loss of function"]
["p.Met469His",3.75e-47,7.39e-92,0.488379646,-0.488379646,"loss of function"]
["p.Met469Ile",8.84e-12,9.48e-23,0.949956061,-0.949956061,"loss of function"]
["p.Met469Pro",0.855186538,0,1.531479035,-1.531479035,"loss of function"]
["p.Met469Ser",4e-42,5.27e-82,0.490025553,-0.490025553,"loss of function"]
["p.Met469Ter",2.62e-06,2.53e-12,1.571957778,-1.571957778,"loss of function"]
["p.Met469Thr",2.89e-10,7.69e-20,0.565817526,-0.565817526,"loss of function"]
["p.Met469Val",7.77e-05,1.1e-09,0.891435465,-0.891435465,"loss of function"]
["p.Met484Ala",6.91e-17,1.2e-32,0.7033144730000001,-0.7033144730000001,"loss of function"]
["p.Met484Arg",1.19e-11,1.75e-22,1.555597135,-1.555597135,"loss of function"]
["p.Met484Asp",1.27e-21,7.22e-42,1.272349123,-1.272349123,"loss of function"]
["p.Met484Cys",0.215318477,2.08e-17,0.50362428,-0.50362428,"loss of function"]
["p.Met484Gly",1.28e-12,2.36e-24,1.521097713,-1.521097713,"loss of function"]
["p.Met484His",6.68e-05,9.37e-10,1.208184893,-1.208184893,"loss of function"]
["p.Met484Lys",4.84e-45,1.05e-87,1.009503165,-1.009503165,"loss of function"]
["p.Met484Ser",2.42e-48,3.48e-94,0.6774368549999999,-0.6774368549999999,"loss of function"]
["p.Met484Ter",6.71e-10,4.07e-19,1.574286007,-1.574286007,"loss of function"]
["p.Met484Thr",4.36e-32,2.44e-62,0.688430608,-0.688430608,"loss of function"]
["p.Met484Trp",7.620000000000001e-14,1e-26,1.485689814,-1.485689814,"loss of function"]
["p.Met484Tyr",4.55e-21,8.77e-41,1.372004335,-1.372004335,"loss of function"]
["p.Met484Val",8.67e-36,1.39e-69,0.685120134,-0.685120134,"loss of function"]
["p.Met498Ala",6.99e-21,1.93e-40,0.696892709,-0.696892709,"loss of function"]
["p.Met498Arg",0.421444187,1.59e-12,1.59483449,-1.59483449,"loss of function"]
["p.Met498Asn",0.361256706,0,0.5100045949999999,-0.5100045949999999,"loss of function"]
["p.Met498Pro",1.88e-14,6.47e-28,0.827677776,-0.827677776,"loss of function"]
["p.Phe281Ala",2.6e-08,4.37e-16,1.441279537,-1.441279537,"loss of function"]
["p.Phe281Arg",2.02e-05,1.09e-10,1.594973039,-1.594973039,"loss of function"]
["p.Phe281Asn",8.68e-06,2.38e-11,1.416672967,-1.416672967,"loss of function"]
["p.Phe281Cys",1.81e-13,5.34e-26,1.508115606,-1.508115606,"loss of function"]
["p.Phe281Gln",2.11e-07,2.28e-14,1.507968578,-1.507968578,"loss of function"]
["p.Phe281Glu",1.1e-08,8.44e-17,1.649085287,-1.649085287,"loss of function"]
["p.Phe281Gly",2.25e-16,1.21e-31,1.544596551,-1.544596551,"loss of function"]
["p.Phe281His",0.397782095,1.11e-16,1.178976746,-1.178976746,"loss of function"]
["p.Phe281Leu",7.24e-12,6.65e-23,1.609141833,-1.609141833,"loss of function"]
["p.Phe281Ser",5.88e-16,7.9e-31,1.556457821,-1.556457821,"loss of function"]
["p.Phe281Thr",3.62e-07,6.38e-14,1.592808719,-1.592808719,"loss of function"]
["p.Phe281Tyr",6.88e-15,9.4e-29,1.397181286,-1.397181286,"loss of function"]
["p.Phe281Val",4.53e-05,4.91e-10,1.59371928,-1.59371928,"loss of function"]
["p.Phe310Glu",1.36e-11,2.24e-22,1.49309591,-1.49309591,"loss of function"]
["p.Phe310Gly",1.28e-22,8.14e-44,1.137346245,-1.137346245,"loss of function"]
["p.Phe310His",0.003876991,3.53e-07,1.642746307,-1.642746307,"loss of function"]
["p.Phe310Leu",3.33e-19,3.8e-37,1.420194409,-1.420194409,"loss of function"]
["p.Phe310Met",4.22e-14,3.18e-27,1.306734722,-1.306734722,"loss of function"]
["p.Phe310Ter",5.18e-06,9.12e-12,1.831573061,-1.831573061,"loss of function"]
["p.Phe352Arg",1.18e-17,3.8e-34,0.595726399,-0.595726399,"loss of function"]
["p.Phe352Asp",1.49e-80,2.45e-157,0.873675215,-0.873675215,"loss of function"]
["p.Phe352Gln",0.040871021,9.209999999999999e-07,0.542213185,-0.542213185,"loss of function"]
["p.Phe352Glu",1.55e-22,1.16e-43,0.476737193,-0.476737193,"loss of function"]
["p.Phe352Gly",0.003637929,2.18e-07,0.828733494,-0.828733494,"loss of function"]
["p.Phe352Pro",1.74e-33,4.45e-65,1.033721421,-1.033721421,"loss of function"]
["p.Phe352Ter",0.605876054,1.11e-08,1.123478223,-1.123478223,"loss of function"]
["p.Phe408Ala",1.86e-20,1.37e-39,1.59442696,-1.59442696,"loss of function"]
["p.Phe408Arg",0.418425177,1.4e-06,1.463782164,-1.463782164,"loss of function"]
["p.Phe408Asn",3.14e-08,6.22e-16,1.679333704,-1.679333704,"loss of function"]
["p.Phe408Gln",1.89e-06,1.4e-12,1.407015424,-1.407015424,"loss of function"]
["p.Phe408Gly",0.0007296,5.36e-08,1.727193463,-1.727193463,"loss of function"]
["p.Phe408Leu",4.18e-17,4.65e-33,1.536300022,-1.536300022,"loss of function"]
["p.Phe408Lys",2.76e-06,2.87e-12,1.502277777,-1.502277777,"loss of function"]
["p.Phe408Met",9.4e-11,9.470000000000001e-21,1.334892282,-1.334892282,"loss of function"]
["p.Phe408Pro",3.35e-11,1.27e-21,1.510024132,-1.510024132,"loss of function"]
["p.Phe408Ser",2.15e-06,1.78e-12,1.567678757,-1.567678757,"loss of function"]
["p.Phe408Thr",0.30927793,0.000305616,1.66950738,-1.66950738,"loss of function"]
["p.Phe408Tyr",1.74e-07,1.61e-14,1.527361755,-1.527361755,"loss of function"]
["p.Phe427Ala",2.83e-14,1.46e-27,1.501903373,-1.501903373,"loss of function"]
["p.Phe427Arg",8.56e-07,3.2e-13,1.577245199,-1.577245199,"loss of function"]
["p.Phe427Asn",4.06e-16,3.87e-31,1.441442883,-1.441442883,"loss of function"]
["p.Phe427Asp",6.069999999999999e-08,2.22e-15,1.565358539,-1.565358539,"loss of function"]
["p.Phe427Cys",8.93e-32,1.01e-61,1.087013021,-1.087013021,"loss of function"]
["p.Phe427Gln",1.71e-09,2.47e-18,1.523816275,-1.523816275,"loss of function"]
["p.Phe427Glu",1.18e-24,8.759999999999999e-48,1.412674448,-1.412674448,"loss of function"]
["p.Phe427Gly",8.91e-08,4.56e-15,1.631809803,-1.631809803,"loss of function"]
["p.Phe427His",1.3e-07,9.31e-15,1.49679463,-1.49679463,"loss of function"]
["p.Phe427Ile",1.07e-22,5.71e-44,0.776435363,-0.776435363,"loss of function"]
["p.Phe427Leu",5.01e-19,8.340000000000001e-37,1.050744409,-1.050744409,"loss of function"]
["p.Phe427Lys",3.65e-06,4.76e-12,1.604497007,-1.604497007,"loss of function"]
["p.Phe427Met",6.75e-15,9e-29,1.215761569,-1.215761569,"loss of function"]
["p.Phe427Pro",2.33e-12,7.519999999999999e-24,1.493542918,-1.493542918,"loss of function"]
["p.Phe427Ser",1.65e-11,3.28e-22,1.558227362,-1.558227362,"loss of function"]
["p.Phe427Ter",2.18e-07,2.44e-14,1.651528284,-1.651528284,"loss of function"]
["p.Phe427Thr",7.25e-12,6.74e-23,1.537359978,-1.537359978,"loss of function"]
["p.Phe427Trp",1.74e-25,2.03e-49,1.251635673,-1.251635673,"loss of function"]
["p.Phe427Tyr",9.899999999999999e-11,1.03e-20,1.532473434,-1.532473434,"loss of function"]
["p.Phe427Val",1.05e-21,4.98e-42,0.988818897,-0.988818897,"loss of function"]
["p.Phe442Ala",9.19e-15,1.63e-28,1.298950454,-1.298950454,"loss of function"]
["p.Phe442Arg",0.003947203,3.9e-07,1.797791838,-1.797791838,"loss of function"]
["p.Phe442Asp",7.88e-19,2.03e-36,1.433062967,-1.433062967,"loss of function"]
["p.Phe442Gln",6.74e-18,1.32e-34,1.750914538,-1.750914538,"loss of function"]
["p.Phe442Glu",1.32e-12,2.49e-24,1.613988093,-1.613988093,"loss of function"]
["p.Phe442Gly",3.02e-08,5.82e-16,1.414722351,-1.414722351,"loss of function"]
["p.Phe442His",5.5e-20,1.12e-38,1.30847228,-1.30847228,"loss of function"]
["p.Phe442Ile",0.289502685,1.3e-06,0.800756559,-0.800756559,"loss of function"]
["p.Phe442Leu",1.1e-20,4.88e-40,1.307898241,-1.307898241,"loss of function"]
["p.Phe442Lys",3.75e-17,3.76e-33,1.544004121,-1.544004121,"loss of function"]
["p.Phe442Met",9.75e-06,2.79e-11,1.47938054,-1.47938054,"loss of function"]
["p.Phe442Pro",2.66e-22,3.4e-43,1.37515492,-1.37515492,"loss of function"]
["p.Phe442Ser",2.32e-11,6.04e-22,0.525716491,-0.525716491,"loss of function"]
["p.Phe442Ter",4e-08,1e-15,1.617502558,-1.617502558,"loss of function"]
["p.Phe442Thr",3.41e-22,5.51e-43,1.020177961,-1.020177961,"loss of function"]
["p.Phe442Tyr",1.13e-109,1.94e-214,0.623670591,-0.623670591,"loss of function"]
["p.Phe451Ala",9.290000000000001e-49,5.25e-95,0.515175735,-0.515175735,"loss of function"]
["p.Phe451Arg",9.870000000000001e-11,1.02e-20,1.630966712,-1.630966712,"loss of function"]
["p.Phe451Asn",0.000466085,2.52e-08,1.709104419,-1.709104419,"loss of function"]
["p.Phe451Asp",1.16e-15,2.99e-30,1.509253719,-1.509253719,"loss of function"]
["p.Phe451Cys",0.101811269,2.25e-11,0.566166295,-0.566166295,"loss of function"]
["p.Phe451Gln",2.35e-10,5.44e-20,1.506313913,-1.506313913,"loss of function"]
["p.Phe451Glu",0.000120793,2.64e-09,1.555011711,-1.555011711,"loss of function"]
["p.Phe451Gly",9.490000000000001e-06,2.76e-11,1.562651979,-1.562651979,"loss of function"]
["p.Phe451His",3.57e-10,1.2e-19,1.439689382,-1.439689382,"loss of function"]
["p.Phe451Lys",2.37e-09,4.56e-18,1.605004766,-1.605004766,"loss of function"]
["p.Phe451Pro",0.000160738,4.42e-09,1.619974982,-1.619974982,"loss of function"]
["p.Phe451Ser",4.74e-06,7.61e-12,1.50962249,-1.50962249,"loss of function"]
["p.Phe451Ter",1.53e-08,1.6e-16,1.600367241,-1.600367241,"loss of function"]
["p.Phe451Thr",3.39e-06,4.14e-12,1.457594801,-1.457594801,"loss of function"]
["p.Phe451Val",3.57e-11,1.4e-21,0.695732624,-0.695732624,"loss of function"]
["p.Phe512Arg",1.12e-08,8.86e-17,1.550667086,-1.550667086,"loss of function"]
["p.Phe512Asp",5.44e-11,3.25e-21,1.460925528,-1.460925528,"loss of function"]
["p.Phe512Gln",9.67e-07,3.82e-13,1.009524436,-1.009524436,"loss of function"]
["p.Phe512Gly",9.78e-06,2.73e-11,1.240168615,-1.240168615,"loss of function"]
["p.Phe512Lys",5.08e-19,8.67e-37,1.467022069,-1.467022069,"loss of function"]
["p.Phe512Ter",2.05e-08,2.81e-16,1.526968408,-1.526968408,"loss of function"]
["p.Phe518Ala",6.73e-32,5.89e-62,0.531046047,-0.531046047,"loss of function"]
["p.Phe518Arg",1.72e-08,1.92e-16,0.798103042,-0.798103042,"loss of function"]
["p.Phe518Asn",3.51e-13,1.89e-25,0.7361191030000001,-0.7361191030000001,"loss of function"]
["p.Phe518Cys",1.24e-29,1.55e-57,0.724249403,-0.724249403,"loss of function"]
["p.Phe518Gln",1.387210499,4.44e-16,1.198634157,-1.198634157,"loss of function"]
["p.Phe518Gly",4.47e-12,2.59e-23,0.736368122,-0.736368122,"loss of function"]
["p.Phe518Lys",2.91e-05,2e-10,0.664671154,-0.664671154,"loss of function"]
["p.Phe518Met",2.18e-19,1.64e-37,0.638939418,-0.638939418,"loss of function"]
["p.Phe518Pro",1.38e-19,6.76e-38,0.828284133,-0.828284133,"loss of function"]
["p.Phe518Ser",9.44e-16,1.94e-30,0.70460414,-0.70460414,"loss of function"]
["p.Phe518Ter",1.2e-06,6.04e-13,1.725919903,-1.725919903,"loss of function"]
["p.Phe518Val",1.56e-08,1.54e-16,0.646993306,-0.646993306,"loss of function"]
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["p.Pro302Ter",4.28e-05,4.26e-10,1.646708497,-1.646708497,"loss of function"]
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["p.Ser348Val",6.54e-14,7.42e-27,1.457379679,-1.457379679,"loss of function"]
["p.Ser375Pro",0.236494819,0.00015852,1.025237578,-1.025237578,"loss of function"]
["p.Ser446Arg",2.93e-11,9.83e-22,1.576713617,-1.576713617,"loss of function"]
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["p.Ser450Lys",2.98e-13,1.41e-25,1.550666959,-1.550666959,"loss of function"]
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["p.Ser450Ter",3.82e-08,9.11e-16,1.689908698,-1.689908698,"loss of function"]
["p.Ser450Tyr",1.46e-08,1.47e-16,1.511291179,-1.511291179,"loss of function"]
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["p.Thr288Ter",4.08e-11,1.87e-21,1.60641064,-1.60641064,"loss of function"]
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["p.Thr299Val",3.44e-10,1.13e-19,1.327331554,-1.327331554,"loss of function"]
["p.Thr304Cys",0.500495504,1.67e-16,0.829142906,-0.829142906,"loss of function"]
["p.Thr304Ile",1.19e-30,1.62e-59,1.213077918,-1.213077918,"loss of function"]
["p.Thr304Leu",2.94e-26,6.37e-51,1.117309663,-1.117309663,"loss of function"]
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["p.Thr304Ter",1.33e-07,9.66e-15,1.652852151,-1.652852151,"loss of function"]
["p.Thr304Val",2.8e-21,3.38e-41,1.0950975,-1.0950975,"loss of function"]
["p.Thr341Arg",0.000332603,1.36e-08,0.782558676,-0.782558676,"loss of function"]
["p.Thr341Asn",2.05e-11,4.97e-22,1.410902741,-1.410902741,"loss of function"]
["p.Thr357Ter",2.13e-23,2.46e-45,1.593173665,-1.593173665,"loss of function"]
["p.Thr420Ala",6.78e-12,5.69e-23,0.845214245,-0.845214245,"loss of function"]
["p.Thr420Arg",0.268670706,1.97e-13,0.532962553,-0.532962553,"loss of function"]
["p.Thr420Asp",4.84e-41,7.16e-80,1.064906606,-1.064906606,"loss of function"]
["p.Thr420Glu",1.67e-27,2.26e-53,0.701718477,-0.701718477,"loss of function"]
["p.Thr420Gly",2.59e-21,2.91e-41,1.456372166,-1.456372166,"loss of function"]
["p.Thr420Lys",0.175863993,0.000350007,0.944547077,-0.944547077,"loss of function"]
["p.Thr420Pro",8.74e-10,6.71e-19,1.552140409,-1.552140409,"loss of function"]
["p.Thr420Ser",1.52e-82,3.02e-161,0.464074687,-0.464074687,"loss of function"]
["p.Thr420Ter",0.108773624,0.0008578770000000001,1.57287565,-1.57287565,"loss of function"]
["p.Thr432Ala",3.14e-10,9.53e-20,1.505550724,-1.505550724,"loss of function"]
["p.Thr432Arg",1.22e-12,2.17e-24,1.592104367,-1.592104367,"loss of function"]
["p.Thr432Asn",4.37e-14,3.41e-27,1.527708445,-1.527708445,"loss of function"]
["p.Thr432Asp",5.3e-11,3.09e-21,1.611052218,-1.611052218,"loss of function"]
["p.Thr432Cys",1.15e-09,1.15e-18,1.564162582,-1.564162582,"loss of function"]
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["p.Thr432Glu",7.139999999999999e-11,5.52e-21,1.582045602,-1.582045602,"loss of function"]
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["p.Thr459Gln",5.5e-22,1.39e-42,0.853795852,-0.853795852,"loss of function"]
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["p.Thr459Leu",2.95e-16,2e-31,0.707304996,-0.707304996,"loss of function"]
["p.Thr459Ser",5.53e-19,9.93e-37,1.212017455,-1.212017455,"loss of function"]
["p.Thr460Arg",2.57e-10,6.399999999999999e-20,1.203651848,-1.203651848,"loss of function"]
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["p.Thr460Ile",4.32e-18,5.56e-35,0.933102252,-0.933102252,"loss of function"]
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["p.Thr460Ter",9.510000000000001e-16,2.02e-30,1.495536127,-1.495536127,"loss of function"]
["p.Thr460Trp",0.339658694,2.78e-17,0.862138368,-0.862138368,"loss of function"]
["p.Thr460Val",1.3e-22,8.21e-44,0.633897986,-0.633897986,"loss of function"]
["p.Thr511Ter",0.07850014900000001,0.000438579,1.661570371,-1.661570371,"loss of function"]
["p.Trp285Pro",9.08e-10,7.29e-19,1.654951499,-1.654951499,"loss of function"]
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["p.Trp289Ter",2.24e-14,9.3e-28,1.664417487,-1.664417487,"loss of function"]
["p.Trp431Ala",2.81e-09,6.36e-18,1.447536831,-1.447536831,"loss of function"]
["p.Trp431Arg",2.66e-14,1.3e-27,1.541844277,-1.541844277,"loss of function"]
["p.Trp431Asn",5.890000000000001e-17,9.03e-33,1.454255183,-1.454255183,"loss of function"]
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["p.Trp431Cys",2.07e-11,5.06e-22,1.499795929,-1.499795929,"loss of function"]
["p.Trp431Gln",1.35e-10,1.88e-20,1.501140935,-1.501140935,"loss of function"]
["p.Trp431Glu",2.18e-18,1.47e-35,1.486656627,-1.486656627,"loss of function"]
["p.Trp431Gly",5.43e-07,1.38e-13,1.557781719,-1.557781719,"loss of function"]
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["p.Trp431Ile",5.02e-13,3.87e-25,1.478057632,-1.478057632,"loss of function"]
["p.Trp431Leu",1.39e-11,2.38e-22,1.603250763,-1.603250763,"loss of function"]
["p.Trp431Lys",6.719999999999999e-05,9.54e-10,1.657221663,-1.657221663,"loss of function"]
["p.Trp431Met",1.77e-08,2.12e-16,1.624827005,-1.624827005,"loss of function"]
["p.Trp431Phe",1.33e-10,1.82e-20,1.350840507,-1.350840507,"loss of function"]
["p.Trp431Pro",3.97e-10,1.5e-19,1.589138535,-1.589138535,"loss of function"]
["p.Trp431Ser",6.05e-13,5.55e-25,1.501516683,-1.501516683,"loss of function"]
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["p.Trp431Thr",1.84e-09,2.83e-18,1.494694869,-1.494694869,"loss of function"]
["p.Trp431Tyr",1.19e-10,1.47e-20,1.457754479,-1.457754479,"loss of function"]
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["p.Trp449Asp",3.72e-07,6.87e-14,1.563721743,-1.563721743,"loss of function"]
["p.Trp449Cys",0.002768448,3.58e-07,1.427569219,-1.427569219,"loss of function"]
["p.Trp449Gln",4.02e-12,2.15e-23,1.499438671,-1.499438671,"loss of function"]
["p.Trp449Glu",2.01e-20,1.6e-39,1.449309786,-1.449309786,"loss of function"]
["p.Trp449Gly",0.00017645,5.19e-09,1.631200415,-1.631200415,"loss of function"]
["p.Trp449His",1.33e-29,1.81e-57,0.767608844,-0.767608844,"loss of function"]
["p.Trp449Leu",3.1e-11,1.11e-21,1.576809052,-1.576809052,"loss of function"]
["p.Trp449Lys",7.17e-13,7.68e-25,1.525116557,-1.525116557,"loss of function"]
["p.Trp449Met",1.08e-05,3.52e-11,1.525178049,-1.525178049,"loss of function"]
["p.Trp449Pro",2.11e-13,7.19e-26,1.528250407,-1.528250407,"loss of function"]
["p.Trp449Ser",3.79e-09,1.12e-17,1.62532519,-1.62532519,"loss of function"]
["p.Trp449Ter",8.16e-06,2.07e-11,1.662374816,-1.662374816,"loss of function"]
["p.Trp449Thr",8.73e-10,6.72e-19,1.656108136,-1.656108136,"loss of function"]
["p.Trp449Val",1.29e-15,3.64e-30,1.688183245,-1.688183245,"loss of function"]
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["p.Trp502Arg",2.26e-05,1.32e-10,1.669412514,-1.669412514,"loss of function"]
["p.Trp502Asp",4.56e-06,7e-12,1.042042644,-1.042042644,"loss of function"]
["p.Trp502Gly",2.17e-19,1.61e-37,0.615332931,-0.615332931,"loss of function"]
["p.Trp502His",1.98e-24,2.37e-47,0.694942325,-0.694942325,"loss of function"]
["p.Trp502Ile",1.71e-05,8.04e-11,1.587240909,-1.587240909,"loss of function"]
["p.Trp502Leu",1.19e-15,3.09e-30,1.059497329,-1.059497329,"loss of function"]
["p.Trp502Lys",0.032346237,4.26e-05,1.50885581,-1.50885581,"loss of function"]
["p.Trp502Met",2.62e-28,6.13e-55,0.814550435,-0.814550435,"loss of function"]
["p.Trp502Phe",1.24e-23,8.580000000000001e-46,0.947601333,-0.947601333,"loss of function"]
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["p.Trp502Ter",1.51e-10,2.34e-20,1.602463946,-1.602463946,"loss of function"]
["p.Trp502Tyr",2.85e-23,4.3e-45,0.828812609,-0.828812609,"loss of function"]
["p.Trp502Val",4.65e-12,2.79e-23,0.949305871,-0.949305871,"loss of function"]
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["p.Tyr329Ter",6.25e-12,5.03e-23,1.659683368,-1.659683368,"loss of function"]
["p.Tyr338Cys",5.43e-36,5.53e-70,0.798149998,-0.798149998,"loss of function"]
["p.Tyr338Gln",0.234939091,4.43e-06,1.036415476,-1.036415476,"loss of function"]
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["p.Tyr338Ser",6.02e-16,8.21e-31,1.35436486,-1.35436486,"loss of function"]
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["p.Tyr379Ala",1.82e-09,2.77e-18,0.591723696,-0.591723696,"loss of function"]
["p.Tyr379Arg",3.02e-48,5.37e-94,0.875522039,-0.875522039,"loss of function"]
["p.Tyr379Asn",2.99e-23,4.75e-45,0.924227762,-0.924227762,"loss of function"]
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["p.Tyr379Cys",8.95e-12,9.83e-23,1.289008364,-1.289008364,"loss of function"]
["p.Tyr379Gln",1.87e-21,1.51e-41,0.612466874,-0.612466874,"loss of function"]
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["p.Tyr379Ile",9.31e-48,4.85e-93,0.698935581,-0.698935581,"loss of function"]
["p.Tyr379Leu",1.97e-22,1.89e-43,0.902536229,-0.902536229,"loss of function"]
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["p.Tyr379Ser",2.34e-13,8.45e-26,0.723516705,-0.723516705,"loss of function"]
["p.Tyr379Thr",1.01e-35,1.9e-69,0.860678658,-0.860678658,"loss of function"]
["p.Tyr379Val",0.21940684,2.81e-08,1.140674142,-1.140674142,"loss of function"]
["p.Tyr385Arg",1.49e-16,5.5e-32,1.468581832,-1.468581832,"loss of function"]
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["p.Tyr385Gln",4.01e-12,2.17e-23,1.515118612,-1.515118612,"loss of function"]
["p.Tyr385His",0.610721474,5.55e-17,0.892435621,-0.892435621,"loss of function"]
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["p.Tyr419Cys",2.54e-08,4.21e-16,1.551293596,-1.551293596,"loss of function"]
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["p.Tyr419Ile",3.19e-14,1.85e-27,1.490400253,-1.490400253,"loss of function"]
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["p.Tyr419Phe",1.63e-27,2.22e-53,1.564134866,-1.564134866,"loss of function"]
["p.Tyr419Pro",1.53e-10,2.39e-20,1.519906649,-1.519906649,"loss of function"]
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["p.Tyr419Thr",7.920000000000001e-14,1.08e-26,1.455301391,-1.455301391,"loss of function"]
["p.Tyr419Trp",2.1e-09,3.64e-18,1.509827165,-1.509827165,"loss of function"]
["p.Tyr419Val",1.67e-08,1.88e-16,1.488196285,-1.488196285,"loss of function"]
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["p.Tyr439Ser",6.79e-28,3.86e-54,0.56197826,-0.56197826,"loss of function"]
["p.Tyr439Ter",3.47e-13,1.89e-25,1.580954413,-1.580954413,"loss of function"]
["p.Tyr466Gly",0.000104421,2.03e-09,1.716196231,-1.716196231,"loss of function"]
["p.Tyr466Leu",1.49e-14,4.22e-28,1.585021516,-1.585021516,"loss of function"]
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["p.Tyr482Arg",2.37e-22,2.68e-43,0.782322222,-0.782322222,"loss of function"]
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["p.Tyr482Ile",1.17e-91,4.1e-179,0.787300951,-0.787300951,"loss of function"]
["p.Tyr482Lys",7.84e-25,3.84e-48,0.869629341,-0.869629341,"loss of function"]
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["p.Tyr482Ser",4.5e-21,8.48e-41,0.932024628,-0.932024628,"loss of function"]
["p.Tyr482Ter",8.290000000000001e-11,7.37e-21,1.574003849,-1.574003849,"loss of function"]
["p.Tyr482Thr",1.17e-16,3.36e-32,1.187528528,-1.187528528,"loss of function"]
["p.Tyr482Trp",1.64e-29,2.68e-57,0.493638392,-0.493638392,"loss of function"]
["p.Tyr482Val",3.71e-32,1.79e-62,0.80490602,-0.80490602,"loss of function"]
["p.Tyr514Asn",0.680093518,2.19e-10,0.485860579,-0.485860579,"loss of function"]
["p.Tyr514Asp",0.077531512,0.000402485,0.541145206,-0.541145206,"loss of function"]
["p.Val274Ter",0.001660922,2.05e-07,1.54934292,-1.54934292,"loss of function"]
["p.Val284Ala",1.91e-20,1.39e-39,0.757230463,-0.757230463,"loss of function"]
["p.Val284Arg",1.24e-10,1.6e-20,1.531223518,-1.531223518,"loss of function"]
["p.Val284Asn",6.78e-09,3.41e-17,1.568905117,-1.568905117,"loss of function"]
["p.Val284Asp",2.27e-11,6.11e-22,1.551066156,-1.551066156,"loss of function"]
["p.Val284Cys",0.296683225,3.9e-07,1.013862994,-1.013862994,"loss of function"]
["p.Val284Gln",7.31e-10,4.79e-19,1.372176194,-1.372176194,"loss of function"]
["p.Val284Glu",3.96e-14,2.82e-27,1.481809819,-1.481809819,"loss of function"]
["p.Val284Gly",8.27e-13,1.01e-24,1.266378019,-1.266378019,"loss of function"]
["p.Val284His",4.43e-07,9.36e-14,1.549447217,-1.549447217,"loss of function"]
["p.Val284Ile",1.47e-74,1.41e-145,1.165305644,-1.165305644,"loss of function"]
["p.Val284Leu",2.11e-12,6.19e-24,1.572939297,-1.572939297,"loss of function"]
["p.Val284Lys",1.14e-08,9.17e-17,1.619053894,-1.619053894,"loss of function"]
["p.Val284Met",1.08e-08,8.32e-17,1.39644165,-1.39644165,"loss of function"]
["p.Val284Pro",6.899999999999999e-23,2.45e-44,1.482409198,-1.482409198,"loss of function"]
["p.Val284Ser",0.008871881,1.46e-07,1.467114217,-1.467114217,"loss of function"]
["p.Val284Thr",0.19986012,0.001612457,1.513315421,-1.513315421,"loss of function"]
["p.Val284Trp",6.07e-20,1.37e-38,1.489031168,-1.489031168,"loss of function"]
["p.Val284Tyr",3.73e-16,3.27e-31,1.568224777,-1.568224777,"loss of function"]
["p.Val295Asn",5.49e-60,5.23e-117,0.799012595,-0.799012595,"loss of function"]
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