This PDF file includes:

• Supplementary Materials and Methods
• Fig. S1. Biochemical profile and LC-MS analysis of hsBCL9_CT peptides.
• Fig. S2. Cellular uptake, Wnt reporter, and coimmunoprecipitation analysis of hsBCL9_CT peptides.
• Fig. S3. Selectivity in multiple signaling pathways and antiproliferation assay of hsBCL9_CT peptides.
• Fig. S4. PK, toxicology, and histology analysis of hsBCL9_CT-24 and hsBCL9_CT-35.
• Fig. S5. IHC staining in patient tumor tissues and PDX tumor models.
• Fig. S6. Wnt pathway gene expression is correlated with CD4⁺CD25⁺FOXP3⁺ T_reg cell infiltration in cancers.
• Fig. S7. Effects of hsBCL9_CT-24 treatment on anticancer immune cells.
• Table S1. Sequences of hsBCL9_CT peptides and related derivatives.
• Table S2. PK and TK profiles of hsBCL9_CT-24 and hsBCL9_CT-35 in mice.
• Table S3. Additional PK, solubility, and stability investigations with hsBCL9_CT-24.

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