Figure 2.
Potency and structure–activity relationship analysis of mAQP3 and hAQP3 inhibition, respectively, by commercially available hit analogues. Shown is t½ of cell shrinking, indicating that water permeability was measured in calcein-loaded, m/hAQP3-expressing CHO cells. No clear potency differences between mAQP3 and hAQP3 inhibition were observed. Error bars indicate standard deviation.
