IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis

Supporting Information

• Supplementary Figure 1 - Comparison of serum levels of sgp130-Fc in mice from (A) Experiment 1 (heterozygous-bred littermates), reproduced from Figure 6, and (B) Experiment 2 with hemizygous-bred PEPCK-sgp130-Fc mice (reproduced from Table 2). Values are individual data points, with mean +/- SEM shown. ND = not detectable n=6-10/group.