This PDF file includes:

• Fig. S1. ¹H NMR spectrum of TMAO monomer.
• Fig. S2. HRMS spectrum of TMAO monomer.
• Fig. S3. Cell adhesion test.
• Fig. S4. GPC graph of KLH, PEG_10k-KLH, and TMAO-KLH conjugates.
• Fig. S5. GPC graph of native uricase, PEG_10k-uricase, and TMAO-uricase conjugates.
• Fig. S6. Protein stability test.
• Table S1. Circulation time of uricase samples after repeated intravenous injections.

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