The PDF file includes:

• Table S1. Crystallographic data collection and refinement statistics.
• Fig. S1. Sxph structural analysis.
• Fig. S2. Sxph sequence, secondary structure, and disulfide map.
• Fig. S3. Comparison of Sxph and representative transferrin family member sequences.
• Fig. S4. Sxph thyroglobulin domain structural analysis.
• Fig. S5. STX-binding site and STX derivatives.
• Fig. S6. Structural comparison of Sxph N1 and C1 domains.
• Fig. S7. Sequence comparison of Sxph and putative Sxph homologs.
• Fig. S8. Na_VPaS:STX and Na_V1.7:STX interactions.
• Legend for movie S1
• References (68–71)

Download PDF

Other Supplementary Material for this manuscript includes the following:

• Movie S1 (.mp4 format). Sxph conformational changes upon STX binding.