=== BROWN=== Reactome Pathway P-value Cytokine Signaling in Immune system 1.76182367234e-09 Platelet activation, signaling and aggregation 5.05867201813e-09 Cell surface interactions at the vascular wall 7.20138835798e-08 Interferon gamma signaling 1.04530575048e-07 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 3.9077930028e-07 Toll-Like Receptors Cascades 5.63879517047e-07 Extracellular matrix organization 1.99762890949e-06 Generation of second messenger molecules 2.05304917809e-06 Signaling by Interleukins 3.18086201865e-06 Toll Like Receptor 4 (TLR4) Cascade 3.50740224159e-06 GPVI-mediated activation cascade 7.59883258885e-06 G alpha (i) signalling events 8.11257805663e-06 Metabolism of Angiotensinogen to Angiotensins 1.5496843332e-05 PD-1 signaling 2.23917892997e-05 Phosphorylation of CD3 and TCR zeta chains 2.68704915458e-05 TCR signaling 3.75264857603e-05 Arachidonic acid metabolism 4.23078658591e-05 Translocation of ZAP-70 to Immunological synapse 5.5984665718e-05 Chemokine receptors bind chemokines 5.60424356454e-05 Death Receptor Signalling 6.02580913904e-05 cGMP effects 6.38289868652e-05 Fcgamma receptor (FCGR) dependent phagocytosis 9.39332104049e-05 Rho GTPase cycle 9.6995317452e-05 Signaling by Rho GTPases 9.6995317452e-05 Costimulation by the CD28 family 0.000127367506364 Interferon Signaling 0.000142117911117 DAP12 interactions 0.00015276360183 Diseases of glycosylation 0.000170370867409 Metabolism of carbohydrates 0.000272048796271 Glycogen storage diseases 0.000272048796271 Myoclonic epilepsy of Lafora 0.000272048796271 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 0.000277372903464 Integrin cell surface interactions 0.000325442272587 RA biosynthesis pathway 0.000337263030852 Activation of C3 and C5 0.000356267905335 Interleukin-3, 5 and GM-CSF signaling 0.000408762057344 MPS I - Hurler syndrome 0.000505022011174 Defective CHST3 causes SEDCJD 0.000505022011174 Diseases associated with glycosaminoglycan metabolism 0.000505022011174 MPS IX - Natowicz syndrome 0.000505022011174 MPS IV - Morquio syndrome A 0.000505022011174 MPS VII - Sly syndrome 0.000505022011174 MPS IIIA - Sanfilippo syndrome A 0.000505022011174 MPS IIIB - Sanfilippo syndrome B 0.000505022011174 Mucopolysaccharidoses 0.000505022011174 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 0.000505022011174 MPS IIID - Sanfilippo syndrome D 0.000505022011174 MPS IIIC - Sanfilippo syndrome C 0.000505022011174 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 0.000505022011174 Defective B4GALT7 causes EDS, progeroid type 0.000505022011174 Defective CHSY1 causes TPBS 0.000505022011174 Defective EXT2 causes exostoses 2 0.000505022011174 Defective CHST6 causes MCDC1 0.000505022011174 Glycosaminoglycan metabolism 0.000505022011174 Defective SLC26A2 causes chondrodysplasias 0.000505022011174 MPS II - Hunter syndrome 0.000505022011174 MPS IV - Morquio syndrome B 0.000505022011174 Defective B3GAT3 causes JDSSDHD 0.000505022011174 Defective CHST14 causes EDS, musculocontractural type 0.000505022011174 MPS VI - Maroteaux-Lamy syndrome 0.000505022011174 Defective PAPSS2 causes SEMD-PA 0.000505022011174 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 0.000517970216997 Signalling by NGF 0.000555354332273 MHC class II antigen presentation 0.000687821472183 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 0.000711480650599 Platelet degranulation 0.0007192300628 Response to elevated platelet cytosolic Ca2+ 0.000750372417212 Degradation of the extracellular matrix 0.000774651677826 Activated TLR4 signalling 0.000811950409561 Toll Like Receptor TLR6:TLR2 Cascade 0.000941376415958 MyD88:Mal cascade initiated on plasma membrane 0.000941376415958 Toll Like Receptor TLR1:TLR2 Cascade 0.000941376415958 Toll Like Receptor 2 (TLR2) Cascade 0.000941376415958 Downstream TCR signaling 0.00101755897179 TRAIL signaling 0.00109537116424 Signal regulatory protein (SIRP) family interactions 0.00109907111053 Fatty Acyl-CoA Biosynthesis 0.00111856128437 Elastic fibre formation 0.00145771196577 Chondroitin sulfate/dermatan sulfate metabolism 0.00151132256758 HS-GAG degradation 0.00170453497437 Nitric oxide stimulates guanylate cyclase 0.00178569823554 Integration of energy metabolism 0.00178909349489 Triglyceride Biosynthesis 0.00189534316106 G-protein beta:gamma signalling 0.00190674946022 Synthesis of UDP-N-acetyl-glucosamine 0.00203802852422 Interleukin-2 signaling 0.00216221125825 Regulation by c-FLIP 0.00235054711043 Dimerization of procaspase-8 0.00235054711043 Caspase-8 activation by cleavage 0.00235054711043 DAP12 signaling 0.00240162670592 Extrinsic Pathway 0.00251257344165 Ligand-receptor interactions 0.00256737936392 Formyl peptide receptors bind formyl peptides and many other ligands 0.00256737936392 Degradation of cysteine and homocysteine 0.00256737936392 ChREBP activates metabolic gene expression 0.00256737936392 G beta:gamma signalling through PI3Kgamma 0.00272519781973 Regulation of actin dynamics for phagocytic cup formation 0.00291565981883 G-protein mediated events 0.00309860577286 HDL-mediated lipid transport 0.00314821853069 Class A/1 (Rhodopsin-like receptors) 0.00321898488848 Peptide ligand-binding receptors 0.00336705123641 Signaling by PDGF 0.00354894365808 Regulation of Complement cascade 0.00359650267989 P2Y receptors 0.0041203576587 CD28 dependent Vav1 pathway 0.0041203576587 Keratan sulfate degradation 0.0041203576587 Signal amplification 0.00433982479484 Interleukin receptor SHC signaling 0.00472369952405 Opioid Signalling 0.00476936819267 Nucleotide-like (purinergic) receptors 0.00489444954742 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.005015259723 Prostanoid ligand receptors 0.00508021929148 Phosphorylation of Emi1 0.00540154976257 Synthesis of 15-eicosatetraenoic acid derivatives 0.00540154976257 Synthesis of 5-eicosatetraenoic acids 0.00540154976257 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 0.00559380222243 Dissolution of Fibrin Clot 0.00671003184311 Iron uptake and transport 0.00696198622761 PLC beta mediated events 0.00696198622761 Inflammasomes 0.00727933415018 Peptide hormone metabolism 0.00749480231608 Metabolism of nucleotides 0.00764963102582 TRIF-mediated TLR3/TLR4 signaling 0.0078554310228 Toll Like Receptor 3 (TLR3) Cascade 0.0078554310228 MyD88-independent cascade 0.0078554310228 Molecules associated with elastic fibres 0.00820013279 Platelet homeostasis 0.00886370185654 TRIF-mediated programmed cell death 0.00894084946674 A tetrasaccharide linker sequence is required for GAG synthesis 0.00911233639745 Heparan sulfate/heparin (HS-GAG) metabolism 0.00916409726735 === TURQUOISE=== Reactome Pathway P-value The citric acid (TCA) cycle and respiratory electron transport 3.81795009891e-34 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 6.98088557479e-22 Respiratory electron transport 7.94354724666e-21 Pyruvate metabolism and Citric Acid (TCA) cycle 1.7229160258e-13 Branched-chain amino acid catabolism 2.83509785533e-09 Mitochondrial Fatty Acid Beta-Oxidation 4.90046921975e-09 Citric acid cycle (TCA cycle) 3.32334600916e-07 Regulation of pyruvate dehydrogenase (PDH) complex 6.10250552047e-07 Fatty acid, triacylglycerol, and ketone body metabolism 1.90578412345e-06 mitochondrial fatty acid beta-oxidation of saturated fatty acids 3.55409964044e-06 Mitochondrial translation initiation 7.79266721367e-06 Mitochondrial translation termination 7.79266721367e-06 Mitochondrial protein import 9.07108027445e-06 Mitochondrial translation 1.00431176733e-05 Mitochondrial translation elongation 2.4567818387e-05 Ubiquinol biosynthesis 2.48039008907e-05 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 3.15851482887e-05 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 3.15851482887e-05 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 3.15851482887e-05 Metabolism of amino acids and derivatives 0.000136074191718 Glucose metabolism 0.000230013852485 Peroxisomal lipid metabolism 0.000555284132691 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 0.00112927894002 Ketone body metabolism 0.00112927894002 Propionyl-CoA catabolism 0.00112927894002 Beta-oxidation of pristanoyl-CoA 0.00127049531279 Lysine catabolism 0.00127049531279 Beta-oxidation of very long chain fatty acids 0.00304852749994 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 0.00304852749994 Organelle biogenesis and maintenance 0.00417852022255 Creatine metabolism 0.00459471071048 Glycogen breakdown (glycogenolysis) 0.00483322671475 Import of palmitoyl-CoA into the mitochondrial matrix 0.00755629799709 Apoptotic cleavage of cell adhesion proteins 0.00755629799709 Nuclear Receptor transcription pathway 0.00905951141166 === GREENYELLOW=== Reactome Pathway P-value Eukaryotic Translation Elongation 7.31589584501e-24 3' -UTR-mediated translational regulation 8.14877279608e-24 L13a-mediated translational silencing of Ceruloplasmin expression 8.14877279608e-24 GTP hydrolysis and joining of the 60S ribosomal subunit 1.02260443926e-23 Formation of a pool of free 40S subunits 2.56774288153e-23 Cap-dependent Translation Initiation 4.68680445945e-23 Eukaryotic Translation Initiation 4.68680445945e-23 Peptide chain elongation 7.34773464421e-23 Eukaryotic Translation Termination 7.34773464421e-23 Viral mRNA Translation 7.34773464421e-23 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 2.60600689185e-22 Translation 9.54217284011e-22 Nonsense-Mediated Decay (NMD) 1.11360195895e-20 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 1.11360195895e-20 SRP-dependent cotranslational protein targeting to membrane 1.35854207719e-20 Influenza Viral RNA Transcription and Replication 4.87579347796e-19 Influenza Life Cycle 1.71107102154e-18 Influenza Infection 3.59478590099e-18 Ribosomal scanning and start codon recognition 1.09828610635e-13 Translation initiation complex formation 1.09828610635e-13 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 1.38639462369e-13 Formation of the ternary complex, and subsequently, the 43S complex 6.67566378475e-13 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.00977072950287 === ROYALBLUE=== Reactome Pathway P-value Interferon Signaling 9.71649143142e-33 Interferon alpha/beta signaling 1.50475639805e-31 Cytokine Signaling in Immune system 3.06747245699e-28 ISG15 antiviral mechanism 3.93570664842e-12 Antiviral mechanism by IFN-stimulated genes 3.93570664842e-12 Interferon gamma signaling 1.59828788614e-09 Negative regulators of RIG-I/MDA5 signaling 1.16352738554e-08 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 1.02132634677e-06 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 2.4689588017e-06 TRAF3-dependent IRF activation pathway 4.07184756244e-06 TRAF6 mediated NF-kB activation 2.22791358091e-05 Regulation of IFNA signaling 2.52764282146e-05 TRAF6 mediated IRF7 activation 5.38978137046e-05 === GREY=== Reactome Pathway P-value === DARKRED=== Reactome Pathway P-value Muscle contraction 1.17147581701e-05 Axon guidance 1.59547940335e-05 Striated Muscle Contraction 2.72149401223e-05 Interaction between L1 and Ankyrins 0.000174204098053 Sialic acid metabolism 0.000367362586559 Platelet degranulation 0.00053453350305 L1CAM interactions 0.000597006886394 Response to elevated platelet cytosolic Ca2+ 0.000839281358818 Rho GTPase cycle 0.000940332703389 Signaling by Rho GTPases 0.000940332703389 NRAGE signals death through JNK 0.00200156879668 Cell death signalling via NRAGE, NRIF and NADE 0.00209999408027 Transmission across Chemical Synapses 0.0027303135558 Synthesis of substrates in N-glycan biosythesis 0.00420426042307 Neuronal System 0.00427249840958 Growth hormone receptor signaling 0.00504033388232 Signalling by NGF 0.0054516402269 GABA receptor activation 0.00555801716938 ECM proteoglycans 0.00555801716938 GABA A receptor activation 0.00591213109953 Synthesis of PIPs at the early endosome membrane 0.00591213109953 Platelet activation, signaling and aggregation 0.00630981529702 Ligand-gated ion channel transport 0.00676844255757 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell 0.00885631354225 Metabolism of polyamines 0.00900111117134 === LIGHTGREEN=== Reactome Pathway P-value Adrenoceptors 0.000544727074136 Passive transport by Aquaporins 0.000991012972298 N-glycan antennae elongation in the medial/trans-Golgi 0.00279507595112 Platelet homeostasis 0.00378075580088 Nitric oxide stimulates guanylate cyclase 0.00435724619751 SHC1 events in ERBB4 signaling 0.00544824989016 GRB2 events in ERBB2 signaling 0.0062379086488 Molecules associated with elastic fibres 0.0062379086488 SHC1 events in ERBB2 signaling 0.00707647964103 Transport to the Golgi and subsequent modification 0.00889716606322 === GREY60=== Reactome Pathway P-value Chemokine receptors bind chemokines 4.51185602105e-07 Cytokine Signaling in Immune system 5.29075699811e-06 Signaling by Interleukins 2.50129448204e-05 O-glycosylation of TSR domain-containing proteins 5.31495376501e-05 Toll Like Receptor 10 (TLR10) Cascade 8.90924160345e-05 MyD88 cascade initiated on plasma membrane 8.90924160345e-05 Toll Like Receptor 5 (TLR5) Cascade 8.90924160345e-05 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 9.41964184717e-05 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.000105076427924 MyD88 dependent cascade initiated on endosome 0.000105076427924 Toll Like Receptor 9 (TLR9) Cascade 0.000129710440805 MyD88:Mal cascade initiated on plasma membrane 0.000150917198032 Toll Like Receptor TLR1:TLR2 Cascade 0.000150917198032 Toll Like Receptor 2 (TLR2) Cascade 0.000150917198032 Toll Like Receptor TLR6:TLR2 Cascade 0.000150917198032 O-linked glycosylation 0.000220510125043 Activated TLR4 signalling 0.000353163438174 Integrin cell surface interactions 0.000417333793305 Toll Like Receptor 4 (TLR4) Cascade 0.000500620512876 Peptide ligand-binding receptors 0.000513126005314 Extracellular matrix organization 0.00054102013736 Interleukin-1 processing 0.000574302344165 TRAF6 Mediated Induction of proinflammatory cytokines 0.000678599928976 Toll-Like Receptors Cascades 0.000959033533598 Activation of the AP-1 family of transcription factors 0.001217922575 Interleukin-1 signaling 0.00123969174099 Class A/1 (Rhodopsin-like receptors) 0.00139737943369 Interleukin-6 signaling 0.00148342760052 Cellular Senescence 0.00154133637509 MyD88-independent cascade 0.00190734783418 Toll Like Receptor 3 (TLR3) Cascade 0.00190734783418 TRIF-mediated TLR3/TLR4 signaling 0.00190734783418 Cellular responses to stress 0.00203674838598 MAP kinase activation in TLR cascade 0.00327132630666 Post-translational protein modification 0.00365621304354 Interferon Signaling 0.00374856411851 FCERI mediated MAPK activation 0.0071422021118 Senescence-Associated Secretory Phenotype (SASP) 0.00741151886969 ATF4 activates genes 0.00770973930137 Signaling by Leptin 0.00832352777355 PERK regulates gene expression 0.00961455039956 === BLACK=== Reactome Pathway P-value IRE1alpha activates chaperones 1.54662270686e-07 XBP1(S) activates chaperone genes 1.40502746951e-06 Unfolded Protein Response (UPR) 1.43391851162e-06 Post-translational protein modification 4.47520488141e-05 Post-translational modification: synthesis of GPI-anchored proteins 7.06946855098e-05 Attenuation phase 8.62492838074e-05 HSF1 activation 0.000148995661537 Separation of Sister Chromatids 0.000158066678308 Mitotic Anaphase 0.000281142705428 Mitotic Metaphase and Anaphase 0.000295525378589 HSF1-dependent transactivation 0.000324429617451 HIV Infection 0.000590065111831 mRNA Splicing 0.000976156952254 mRNA Splicing - Major Pathway 0.000976156952254 Processing of Capped Intron-Containing Pre-mRNA 0.00116733864237 Cell Cycle Checkpoints 0.00129221750177 p38MAPK events 0.00142350385691 Cellular response to heat stress 0.00195577258372 Resolution of Sister Chromatid Cohesion 0.00214005788675 Synthesis of glycosylphosphatidylinositol (GPI) 0.00267846472021 Metabolism of nucleotides 0.00274455236611 Signalling to RAS 0.0030637328509 M Phase 0.00318411091455 eNOS activation and regulation 0.00320961076549 Metabolism of nitric oxide 0.00320961076549 HIV Life Cycle 0.00329939785013 Mitotic Prometaphase 0.00330306577854 Gamma carboxylation, hypusine formation and arylsulfatase activation 0.003783932095 Activation of ATR in response to replication stress 0.00418363408427 Scavenging by Class F Receptors 0.00456993723964 Nonhomologous End-joining (NHEJ) 0.00456993723964 Translation 0.00484675884021 Defective MOGS causes MOGS-CDG (CDG-2b) 0.00537138329124 Defective RFT1 causes RFT1-CDG (CDG-1n) 0.00537138329124 Defective ALG9 causes ALG9-CDG (CDG-1l) 0.00537138329124 Defective MAN1B1 causes MRT15 0.00537138329124 Defective ALG8 causes ALG8-CDG (CDG-1h) 0.00537138329124 Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 0.00537138329124 Defective ALG12 causes ALG12-CDG (CDG-1g) 0.00537138329124 Defective ALG11 causes ALG11-CDG (CDG-1p) 0.00537138329124 Defective MPDU1 causes MPDU1-CDG (CDG-1f) 0.00537138329124 Defective ALG1 causes ALG1-CDG (CDG-1k) 0.00537138329124 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) 0.00537138329124 Defective ALG3 causes ALG3-CDG (CDG-1d) 0.00537138329124 Defective ALG6 causes ALG6-CDG (CDG-1c) 0.00537138329124 Defective MGAT2 causes MGAT2-CDG (CDG-2a) 0.00537138329124 Defective ALG2 causes ALG2-CDG (CDG-1i) 0.00537138329124 Diseases associated with N-glycosylation of proteins 0.00537138329124 Asparagine N-linked glycosylation 0.00537138329124 Activation of gene expression by SREBF (SREBP) 0.00555141205965 2-LTR circle formation 0.00632242903639 eNOS activation 0.00632242903639 RAF phosphorylates MEK 0.00632242903639 MEK activation 0.00632242903639 Activation of NF-kappaB in B cells 0.00654226056314 Signalling to ERKs 0.00779873382626 G2/M Checkpoints 0.00779873382626 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 0.00787868404259 Host Interactions of HIV factors 0.00795159313422 Synthesis of diphthamide-EEF2 0.00833059664438 Cytosolic tRNA aminoacylation 0.00871005561567 === MAGENTA=== Reactome Pathway P-value Regulation of gene expression by Hypoxia-inducible Factor 0.00484389373073 === TAN=== Reactome Pathway P-value Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor 5.99722367397e-08 NICD traffics to nucleus 2.73344141455e-06 Notch-HLH transcription pathway 2.73344141455e-06 Pre-NOTCH Processing in the Endoplasmic Reticulum 1.00602137247e-05 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 1.75011586024e-05 Pre-NOTCH Transcription and Translation 1.88348061344e-05 A third proteolytic cleavage releases NICD 4.15072464549e-05 Signaling by NOTCH 5.93131225221e-05 Signaling by NOTCH3 8.05708965778e-05 Signaling by NOTCH4 8.05708965778e-05 Pre-NOTCH Expression and Processing 9.48712373465e-05 Constitutive Signaling by NOTCH1 HD Domain Mutants 0.000216978212533 Non-integrin membrane-ECM interactions 0.000356785098115 Pre-NOTCH Processing in Golgi 0.000382285336684 Laminin interactions 0.000805544606867 G alpha (q) signalling events 0.000837699475083 ECM proteoglycans 0.00100247189723 Effects of PIP2 hydrolysis 0.00103389150017 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.00114669656283 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.00114669656283 Ca2+ pathway 0.00138940628679 Activated NOTCH1 Transmits Signal to the Nucleus 0.00177206724697 Gastrin-CREB signalling pathway via PKC and MAPK 0.0018647397993 Signaling by VEGF 0.00221725035119 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 0.00272080751994 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.00272080751994 Signaling by NOTCH1 0.00272080751994 Signaling by NOTCH1 HD Domain Mutants in Cancer 0.00272080751994 Signaling by NOTCH1 in Cancer 0.00272080751994 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.00272080751994 FBXW7 Mutants and NOTCH1 in Cancer 0.00272080751994 Acetylcholine regulates insulin secretion 0.00277776840127 Signaling by EGFR 0.00331841448844 Signaling by Overexpressed Wild-Type EGFR in Cancer 0.00331841448844 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.00350444195964 Signaling by EGFRvIII in Cancer 0.00350444195964 Signaling by EGFR in Cancer 0.00350444195964 Cell junction organization 0.00494084656985 PLC beta mediated events 0.00499064103894 Axon guidance 0.00508238933505 G-protein mediated events 0.00532454074266 Inositol phosphate metabolism 0.00532454074266 Degradation of the extracellular matrix 0.0058126197905 Downstream signaling of activated FGFR 0.00717746657514 Downstream signal transduction 0.00984554299121 GAB1 signalosome 0.00998018798534 Integration of energy metabolism 0.00998018798534 === RED=== Reactome Pathway P-value Extracellular matrix organization 1.06075346513e-23 Collagen formation 2.84584694114e-14 Assembly of collagen fibrils and other multimeric structures 3.60046956962e-12 Collagen biosynthesis and modifying enzymes 7.15640640282e-12 ECM proteoglycans 6.55279205877e-09 Elastic fibre formation 1.41330947294e-08 Syndecan interactions 2.45479472896e-07 Axon guidance 1.14366740418e-06 Non-integrin membrane-ECM interactions 1.8928820836e-06 Crosslinking of collagen fibrils 6.89075297539e-06 Response to elevated platelet cytosolic Ca2+ 9.78034507408e-06 Platelet activation, signaling and aggregation 1.89399590848e-05 Integrin cell surface interactions 2.29579927302e-05 Platelet degranulation 2.5959196922e-05 MPS VI - Maroteaux-Lamy syndrome 3.24056837949e-05 MPS IIIC - Sanfilippo syndrome C 3.24056837949e-05 MPS IIID - Sanfilippo syndrome D 3.24056837949e-05 MPS I - Hurler syndrome 3.24056837949e-05 MPS IV - Morquio syndrome A 3.24056837949e-05 MPS IIIB - Sanfilippo syndrome B 3.24056837949e-05 MPS IIIA - Sanfilippo syndrome A 3.24056837949e-05 MPS VII - Sly syndrome 3.24056837949e-05 Defective B4GALT7 causes EDS, progeroid type 3.24056837949e-05 Mucopolysaccharidoses 3.24056837949e-05 Defective EXT2 causes exostoses 2 3.24056837949e-05 MPS IX - Natowicz syndrome 3.24056837949e-05 MPS IV - Morquio syndrome B 3.24056837949e-05 Defective B3GAT3 causes JDSSDHD 3.24056837949e-05 Defective PAPSS2 causes SEMD-PA 3.24056837949e-05 MPS II - Hunter syndrome 3.24056837949e-05 Glycosaminoglycan metabolism 3.24056837949e-05 Defective CHSY1 causes TPBS 3.24056837949e-05 Defective CHST6 causes MCDC1 3.24056837949e-05 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 3.24056837949e-05 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 3.24056837949e-05 Diseases associated with glycosaminoglycan metabolism 3.24056837949e-05 Defective SLC26A2 causes chondrodysplasias 3.24056837949e-05 Defective CHST14 causes EDS, musculocontractural type 3.24056837949e-05 Defective CHST3 causes SEDCJD 3.24056837949e-05 Scavenging by Class A Receptors 4.02316291068e-05 Molecules associated with elastic fibres 7.84448361743e-05 EPH-Ephrin signaling 0.000589879226898 Chondroitin sulfate biosynthesis 0.000608058592562 TGF-beta receptor signaling activates SMADs 0.00089905881643 SMAD2/3 Phosphorylation Motif Mutants in Cancer 0.000926209754826 TGFBR2 MSI Frameshift Mutants in Cancer 0.000926209754826 TGFBR2 Kinase Domain Mutants in Cancer 0.000926209754826 SMAD4 MH2 Domain Mutants in Cancer 0.000926209754826 TGFBR1 KD Mutants in Cancer 0.000926209754826 TGFBR1 LBD Mutants in Cancer 0.000926209754826 Signaling by TGF-beta Receptor Complex in Cancer 0.000926209754826 Loss of Function of TGFBR1 in Cancer 0.000926209754826 Loss of Function of SMAD4 in Cancer 0.000926209754826 Loss of Function of TGFBR2 in Cancer 0.000926209754826 Signaling by TGF-beta Receptor Complex 0.000926209754826 Loss of Function of SMAD2/3 in Cancer 0.000926209754826 SMAD2/3 MH2 Domain Mutants in Cancer 0.000926209754826 Sema4D induced cell migration and growth-cone collapse 0.00147839530498 Diseases of glycosylation 0.00162449792486 NCAM1 interactions 0.00197820953838 Chondroitin sulfate/dermatan sulfate metabolism 0.00205488170752 Downregulation of TGF-beta receptor signaling 0.00215506392699 A tetrasaccharide linker sequence is required for GAG synthesis 0.00215506392699 Platelet homeostasis 0.00219770289449 Sema4D in semaphorin signaling 0.0025669846833 O-glycosylation of TSR domain-containing proteins 0.00261130339275 Semaphorin interactions 0.00283524866542 Keratan sulfate biosynthesis 0.00303311216956 O-linked glycosylation 0.00418968325832 Binding and Uptake of Ligands by Scavenger Receptors 0.00444448771074 Dermatan sulfate biosynthesis 0.00629385566385 Keratan sulfate/keratin metabolism 0.00631188813746 EPHA-mediated growth cone collapse 0.00718380843951 Smooth Muscle Contraction 0.0074406488393 Serotonin receptors 0.0081679406692 Cell surface interactions at the vascular wall 0.00978901785474