KEGGID Pvalue OddsRatio ExpCount Count Size Term Symbols 1 4916 0.002054265 2.420314254 9.655919271 19 64 Melanogenesis KIT;KITLG;CAMK2D;GNAI1;PLCB1;EP300;FZD6;FZD2;WNT16;WNT9A;ADCY3;WNT3A;PLCB4;CREB3L1;KRAS;FZD4;WNT2B;ADCY6;DVL1 2 5012 0.00209496 2.016239316 16.29436377 28 108 Parkinson's disease CASP3;ATP5G1;ND2;COX1;ATP6;COX3;ND4L;ND4;ND5;ND6;COX6C;COX6A1;SLC18A2;LOC100156879;ATP5G3;NDUFA1;PPID;LOC100516606;NDUFA12;NDUFS6;NDUFA10;NDUFB11;NDUFV1;UBE2G1;GPR37;ATP5D;UBE2J2;LOC100524239 3 310 0.002970455 3.299615317 4.526212159 11 30 Lysine degradation DLST;PLOD2;ALDH2;EHMT2;SETD1B;SETD1A;AASS;NSD2;OGDHL;NSD1;ALDH3A2 4 4512 0.004885995 2.314477469 8.901550578 17 59 ECM-receptor interaction CD47;SPP1;COL11A1;TNC;ITGA2;SDC4;COL5A3;COL5A1;THBS1;ITGB8;ITGB5;SDC2;THBS2;ITGA6;THBS4;HSPG2;ITGA11 5 4510 0.005015696 1.802926169 19.61358602 31 130 Focal adhesion MYLK;VCL;SPP1;VEGFA;COL11A1;CAPN2;TNC;ITGA2;COL5A3;COL5A1;THBS1;MET;ITGB8;XIAP;BCL2;AKT1;ITGB5;VAV2;THBS2;SOS2;ACTN2;MYL9;ITGA6;LOC100511937;THBS4;PDGFA;SOS1;ITGA11;VEGFB;ZYX;PAK1 6 4810 0.005244195 1.760632184 21.27319714 33 141 Regulation of actin cytoskeleton FGFR2;MYLK;VCL;SLC9A1;ITGA2;ARAF;CFL1;TMSB4X;ITGB8;CD14;FGFR4;ITGB5;VAV2;CSK;DIAPH2;SOS2;ACTN2;MYL9;ITGA6;ARPC1A;ARPC1B;LOC100511937;PFN1;CHRM4;KRAS;PDGFA;SOS1;ITGA11;PIP4K2A;ARHGEF12;GNA12;ENAH;PAK1 7 5211 0.006061737 2.496452421 6.940191976 14 46 Renal cell carcinoma HIF1A;VEGFA;ARAF;MET;EPAS1;AKT1;EP300;SOS2;LOC100511937;KRAS;SOS1;VEGFB;EGLN2;PAK1 8 4260 0.006822876 2.284757119 8.448929363 16 56 Cardiac muscle contraction CACNB4;SLC9A1;COX1;COX3;COX6C;TPM1;TNNI3;COX6A1;ACTC1;TNNC1;LOC100156879;ATP1B3;LOC100516606;CACNA2D2;CACNB2;LOC100524239 9 5410 0.008395678 2.158277405 9.354171794 17 62 Hypertrophic cardiomyopathy (HCM) CACNB4;ITGA2;DMD;ITGB8;TPM1;TNNI3;LMNA;ITGB5;PRKAA1;ACTC1;TNNC1;PRKAB2;ITGA6;PRKAG2;CACNA2D2;ITGA11;CACNB2 10 4720 0.011122138 2.608388704 5.280580852 11 35 Long-term potentiation PPP3CA;ARAF;CAMK2D;PLCB1;ITPR3;EP300;RPS6KA2;CAMK4;PLCB4;KRAS;GRIN2D 11 3040 0.011202106 1.907094595 12.67339404 21 84 Spliceosome SMNDC1;DHX16;PRPF19;SNRPD3;SRSF5;SF3A1;SF3B4;SF3B1;PRPF3;SF3B3;PLRG1;HNRNPA3;SF3A2;DHX8;PRPF31;SF3B2;EFTUD2;PPIH;SART1;XAB2;PRPF8 12 3010 0.011693 2.065222048 9.655919271 17 64 Ribosome RPS23;RPS18;RPL22;RPS4X;RPS3A;RPL23;RPL7;RPL6;RPS3;RPS6;RPS24;RPL30;RPLP1;RPL39;RPS25;RPL34;RPS27 13 4150 0.014852454 2.355384704 6.185823283 12 41 mTOR signaling pathway HIF1A;VEGFA;RPS6;AKT1;MTOR;PRKAA1;ULK1;LOC100511937;RPTOR;RPS6KA2;RICTOR;VEGFB 14 190 0.015002058 1.761525402 15.38912134 24 102 Oxidative phosphorylation ATP5I;ATP5G1;ND2;COX1;ATP6;COX3;ND4L;ND4;ND5;ND6;COX6C;COX6A1;LOC100156879;ATP5G3;NDUFA1;LOC100516606;NDUFA12;ATP6V0C;NDUFS6;NDUFA10;NDUFB11;NDUFV1;ATP5D;LOC100524239 15 5010 0.015070177 1.663527397 19.46271228 29 129 Alzheimer's disease RYR3;CAPN1;PPP3CA;CASP3;CAPN2;LPL;ATP5G1;COX1;ATP6;COX3;COX6C;COX6A1;PLCB1;ITPR3;LOC100156879;ATF6;ATP5G3;LRP1;NDUFA1;PLCB4;LOC100516606;NDUFA12;NDUFS6;NDUFA10;GRIN2D;NDUFB11;NDUFV1;ATP5D;LOC100524239 16 4144 0.015912295 1.639304092 20.36795471 30 135 Endocytosis CXCR4;FGFR2;FOLR3;KIT;FOLR2;TFRC;FOLR1;RAB11A;MET;FGFR4;RAB5A;RAB11FIP2;DNM1;CHMP4C;VTA1;GRK3;STAM2;PRKCI;PDCD6IP;CHMP6;ASAP2;ARFGAP2;CHMP2B;EHD1;EPS15;CBL;GRK4;DAB2;SH3GL1;ACAP3 17 5414 0.016054562 2.027917365 9.203298056 16 61 Dilated cardiomyopathy CACNB4;ITGA2;DMD;ITGB8;TPM1;TNNI3;LMNA;ITGB5;ACTC1;TNNC1;ITGA6;ADCY3;CACNA2D2;ITGA11;ADCY6;CACNB2 18 4360 0.017206313 1.843007126 12.37164657 20 82 Axon guidance CXCR4;PPP3CA;CFL1;MET;NTN1;EFNB2;GNAI1;EFNA1;NFATC4;SEMA4A;EPHA4;ROBO2;KRAS;ABLIM2;PLXNB1;ARHGEF12;SEMA3D;SEMA4C;L1CAM;PAK1 19 4010 0.018070731 1.528318638 27.30814669 38 181 MAPK signaling pathway CACNB4;FGFR2;PPP3CA;CASP3;BDNF;MAPK12;GADD45A;CD14;AKT1;FGFR4;RELA;FOS;MAPKAPK5;SIX4;TAB2;SOS2;CACNA1E;CACNA1G;LOC100513542;TRAF2;RPS6KA2;RASA2;CACNA2D2;MAPK8IP1;KRAS;MECOM;NTRK2;ECSIT;PDGFA;SOS1;MAP3K14;MAPKAPK2;RASGRP1;CACNB2;STK3;DAXX;GNA12;PAK1 20 561 0.025373099 2.2331514 5.884075806 11 39 Glycerolipid metabolism DGAT1;LPL;AGPAT1;ALDH2;PNPLA3;MBOAT1;GPAT4;DGKE;PLPP1;DGKZ;ALDH3A2 21 4540 0.02589298 1.992487479 8.147181885 14 54 Gap junction GNA11;PRKG1;TUBB;GNAI1;PLCB1;ITPR3;SOS2;ADCY3;TUBB4B;PLCB4;KRAS;PDGFA;SOS1;ADCY6 22 600 0.025895417 2.670296548 3.771843465 8 25 Sphingolipid metabolism ARSA;SMPD4;KDSR;ASAH1;PLPP1;B4GALT6;SMPD3;ACER3 23 5016 0.027198105 1.566554665 20.36795471 29 135 Huntington's disease HTT;CASP3;BDNF;ATP5G1;COX1;ATP6;COX3;COX6C;COX6A1;PLCB1;EP300;LOC100156879;ATP5G3;NDUFA1;PPID;PLCB4;LOC100516606;CREB3L1;NDUFA12;DCTN1;IFT57;NDUFS6;REST;NDUFA10;NDUFB11;NDUFV1;ATP5D;HIP1;LOC100524239 24 5214 0.030401559 2.155516096 6.034949545 11 40 Glioma ARAF;CAMK2D;AKT1;MTOR;CDKN1A;PLCG1;SOS2;LOC100511937;KRAS;PDGFA;SOS1 25 563 0.032396442 3.090310019 2.564853556 6 17 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis PIGK;PIGA;PIGN;DPM2;PIGZ;GPAA1 26 512 0.042589411 2.831960461 2.715727295 6 18 Mucin type O-Glycan biosynthesis ST3GAL1;GALNT2;GALNT15;GALNT12;GALNT3;GCNT4 27 1100 0.045189706 1.207362539 118.1341373 134 783 Metabolic pathways PLA2G7;ST3GAL4;ABO;ATP5I;ALOX15;ACO2;DHRS4;DPYD;DGAT1;DLD;GFPT1;DDOST;AMY2;ANPEP;PGD;PGM1;HSD17B4;SAT1;DLST;CYP19A1;CYP19A3;SRM;MAOB;ST3GAL1;ACSL4;EPRS;ATP5G1;DNMT1;PIGK;AGPAT1;CDS1;ALDH2;AK5;ND2;COX1;ATP6;COX3;ND4L;ND4;ND5;ND6;P4HA1;COX6C;PNPLA3;CYP2R1;RDH10;MBOAT1;COX6A1;DOLK;PLCG1;LOC100152566;UGT1A6;PLCB1;SMPD4;NME7;GPAT4;KDSR;GALNT2;HSD17B8;GLCE;RDH11;ACADSB;PTGES2;SDS;UAP1;PTDSS1;LOC100156879;PIGA;POLR3H;ALDH5A1;RRM2B;IDH3A;GGT5;GALNT15;SAT2;PGAM2;ACSL3;SCLY;CDO1;DGKE;AMACR;GNPDA1;GALNT12;ASAH1;FUT4;ATP5G3;AASS;REV3L;POLA2;XYLT2;DHRS3;HLCS;NDUFA1;PLPP1;GALNT3;PDHB;MGAT5B;B4GALNT1;PLCB4;B4GALT6;POLR1A;SMPD3;GCNT4;LOC100518620;CHSY3;ATP6V0C;DGKZ;NDUFS6;ACADVL;PLCD3;ALG6;NDUFA10;GALK1;CMPK1;OGDHL;PIGN;DPM2;BDH2;NDUFV1;B3GALT6;ATP5D;PAFAH1B2;CHPT1;MGAT4A;B3GNT2;LOC100524239;GPT;PYCR2;CTPS1;ALDH3A2;GPAA1;POLD1;UCK1;GAA 28 5412 0.047233487 1.847083333 7.996308147 13 53 Arrhythmogenic right ventricular cardiomyopathy (ARVC) CACNB4;ITGA2;DMD;ITGB8;LMNA;ITGB5;DSP;ACTN2;ITGA6;CACNA2D2;ITGA11;CACNB2;CTNNA2 29 3013 0.050867639 1.5748133 14.63475265 21 97 RNA transport SUMO2;EEF1A1;EIF4A2;SUMO1;NUP153;RANGAP1;NUP214;EIF3E;PRMT5;LOC100511376;POM121C;TACC3;NUP160;TPR;ELAC2;NXT2;EIF3H;EIF1AX;GEMIN5;EIF2S3;NUP85 30 4270 0.053594116 1.685464359 10.5611617 16 70 Vascular smooth muscle contraction MYLK;KCNMA1;EDNRA;ARAF;GNA11;ACTA2;PLCB1;ITPR3;MYL9;KCNMB2;ADCY3;PLCB4;ADCY6;ARHGEF12;CALD1;GNA12 31 5200 0.053886916 1.349322857 34.85183362 44 231 Pathways in cancer HIF1A;RARB;FGFR2;KIT;VEGFA;CASP3;RXRA;ITGA2;KITLG;ARAF;MET;EPAS1;XIAP;BCL2;AKT1;MTOR;RELA;FOS;CDKN1A;PLCG1;EP300;SOS2;FZD6;BCR;ITGA6;FZD2;WNT16;LOC100511937;MSH3;WNT9A;TRAF2;WNT3A;KRAS;MECOM;CBL;PDGFA;SOS1;FZD4;TPR;WNT2B;VEGFB;EGLN2;DVL1;CTNNA2 32 4141 0.068158327 1.454255171 18.55746985 25 123 Protein processing in endoplasmic reticulum CAPN1;DDOST;CAPN2;BAK1;LMAN2;HSPH1;BCL2;ATF6B;TRAM1;SEC63;RRBP1;SEC23A;ATF6;SEC24A;TRAF2;MBTPS1;ERLEC1;SEC61G;HSPBP1;UBQLN4;YOD1;UBE2G1;DNAJC10;SSR4;UBE2J2 33 120 0.070433955 3.230588787 1.659611125 4 11 Primary bile acid biosynthesis HSD17B4;CYP39A1;CH25H;AMACR 34 4722 0.080271195 1.52750533 12.82426778 18 85 Neurotrophin signaling pathway IRAK1;BDNF;CAMK2D;MAPK12;BCL2;AKT1;RELA;PLCG1;CSK;SOS2;LOC100511937;RPS6KA2;CAMK4;SH2B1;KRAS;NTRK2;SOS1;MAPKAPK2 35 5223 0.094083007 1.821073794 5.582328329 9 37 Non-small cell lung cancer RARB;RXRA;ARAF;AKT1;PLCG1;SOS2;LOC100511937;KRAS;SOS1 36 4210 0.101968008 1.557694196 9.80679301 14 65 Apoptosis IRAK1;MYD88;CAPN1;PRKAR1A;PPP3CA;CASP3;CAPN2;XIAP;BCL2;AKT1;RELA;LOC100511937;TRAF2;MAP3K14 37 4971 0.102521778 1.717171717 6.487570761 10 43 Gastric acid secretion MYLK;SLC9A1;CAMK2D;GNAI1;PLCB1;ITPR3;ADCY3;ATP1B3;PLCB4;ADCY6 38 3018 0.109406276 1.640671446 7.392813192 11 49 RNA degradation DCPS;HSPD1;BTG1;CNOT7;EXOSC4;EXOSC5;CNOT6L;DCP2;CNOT3;EDC4;EXOSC2 39 20 0.120818308 1.996123655 3.470095988 6 23 Citrate cycle (TCA cycle) ACO2;DLD;DLST;IDH3A;PDHB;OGDHL 40 4910 0.126251437 1.385267141 15.38912134 20 102 Insulin signaling pathway SLC2A4;PRKAR1A;SREBF1;ARAF;PPP1R3C;SOCS2;RPS6;AKT1;MTOR;PRKAA1;SOS2;PRKAB2;PRKCI;LOC100511937;RPTOR;PRKAG2;KRAS;CBL;SOS1;RHOQ 41 4962 0.128952641 1.741385887 5.129707113 8 34 Vasopressin-regulated water reabsorption RAB11A;DYNC1H1;RAB5A;DYNC2LI1;ADCY3;CREB3L1;DCTN1;ADCY6 42 4660 0.129322315 1.440855069 11.91902535 16 79 T cell receptor signaling pathway PPP3CA;TEC;MAPK12;AKT1;RELA;FOS;VAV2;NFATC4;SOS2;LOC100511937;KRAS;CBL;SOS1;MAP3K14;RASGRP1;PAK1 43 5221 0.137915197 1.643398846 6.034949545 9 40 Acute myeloid leukemia KIT;ARAF;AKT1;MTOR;RELA;SOS2;LOC100511937;KRAS;SOS1 44 4920 0.140651098 1.510815308 8.599803101 12 57 Adipocytokine signaling pathway SLC2A4;RXRA;CPT1A;ACSL4;AKT1;MTOR;RELA;PRKAA1;PRKAB2;ACSL3;TRAF2;PRKAG2 45 601 0.146612607 2.018327068 2.866601034 5 19 Glycosphingolipid biosynthesis - lacto and neolacto series ST3GAL4;ABO;LOC100152566;FUT4;B3GNT2 46 5215 0.147544411 1.442707543 10.41028796 14 69 Prostate cancer FGFR2;ARAF;BCL2;AKT1;MTOR;RELA;CDKN1A;EP300;SOS2;LOC100511937;CREB3L1;KRAS;PDGFA;SOS1 47 5220 0.150266559 1.519285309 7.845434408 11 52 Chronic myeloid leukemia ARAF;AKT1;RELA;CDKN1A;SOS2;BCR;LOC100511937;KRAS;MECOM;CBL;SOS1 48 780 0.150873739 Inf 0.150873739 1 1 Biotin metabolism HLCS 49 5217 0.164912415 1.616056671 5.43145459 8 36 Basal cell carcinoma FZD6;FZD2;WNT16;WNT9A;WNT3A;FZD4;WNT2B;DVL1 50 72 0.166311694 3.761047463 0.754368693 2 5 Synthesis and degradation of ketone bodies OXCT1;BDH2 51 5100 0.172055616 1.542895846 6.336697022 9 42 Bacterial invasion of epithelial cells VCL;MET;DNM1;CD2AP;ARPC1A;ARPC1B;LOC100511937;CBL;CTNNA2 52 4662 0.177359685 1.489045998 7.241939454 10 48 B cell receptor signaling pathway PPP3CA;AKT1;RELA;FOS;VAV2;NFATC4;SOS2;LOC100511937;KRAS;SOS1 53 4310 0.177577611 1.325199171 14.33300517 18 95 Wnt signaling pathway PPP3CA;CAMK2D;PPP2R5D;PLCB1;NFATC4;EP300;PRICKLE1;FZD6;FZD2;WNT16;WNT9A;WNT3A;PLCB4;FZD4;WNT2B;TBL1XR1;DVL1;PPP2R5E 54 4666 0.181307989 1.447770996 8.147181885 11 54 Fc gamma R-mediated phagocytosis CFL1;AKT1;VAV2;PLCG1;DNM1;ARPC1A;ARPC1B;LOC100511937;ASAP2;PLPP1;PAK1 55 4912 0.184230092 1.415141431 9.052424317 12 60 GnRH signaling pathway MMP14;CAMK2D;MAPK12;GNA11;PLCB1;ITPR3;SOS2;ADCY3;PLCB4;KRAS;SOS1;ADCY6 56 330 0.184451562 1.559874608 5.582328329 8 37 Arginine and proline metabolism SAT1;SRM;MAOB;ALDH2;P4HA1;SAT2;PYCR2;ALDH3A2 57 4070 0.194783636 1.450440107 7.392813192 10 49 Phosphatidylinositol signaling system CDS1;PLCG1;PLCB1;ITPR3;DGKE;LOC100511937;PLCB4;DGKZ;PIP4K2A;PLCD3 58 4146 0.19787153 1.414451827 8.298055624 11 55 Peroxisome DHRS4;HSD17B4;ACSL4;CRAT;PEX2;ACSL3;AMACR;PEX16;SLC25A17;PEX14;DECR2 59 4012 0.200032225 1.385853509 9.203298056 12 61 ErbB signaling pathway ARAF;CAMK2D;AKT1;MTOR;CDKN1A;PLCG1;SOS2;LOC100511937;KRAS;CBL;SOS1;PAK1 60 564 0.212921539 1.413764511 7.543686931 10 50 Glycerophospholipid metabolism AGPAT1;CDS1;MBOAT1;LYPLA1;GPAT4;PTDSS1;DGKE;PLPP1;DGKZ;CHPT1 61 4142 0.216797958 1.294089495 12.97514152 16 86 Lysosome CTSV;ARSA;IGF2R;NPC2;SCARB2;CTSD;LIPA;CD164;LAMP2;AP1B1;AP1M1;ASAH1;ATP6V0C;CTSC;MANBA;GAA 62 5014 0.221015565 1.521198274 4.978833374 7 33 Amyotrophic lateral sclerosis (ALS) PPP3CA;CASP3;MAPK12;BCL2;RAB5A;GRIN2D;DAXX 63 53 0.223659624 2.115983607 1.659611125 3 11 Ascorbate and aldarate metabolism ALDH2;UGT1A6;ALDH3A2 64 3450 0.223659624 2.115983607 1.659611125 3 11 Non-homologous end-joining POLL;PRKDC;FEN1 65 290 0.225498632 2.819967267 0.905242432 2 6 "Valine, leucine and isoleucine biosynthesis" VARS;PDHB 66 4730 0.22963321 1.41307947 6.789318238 9 45 Long-term depression ARAF;GNA11;PRKG1;GNAI1;PLCB1;ITPR3;PLCB4;KRAS;GNA12 67 4970 0.231717237 1.378877968 7.694560669 10 51 Salivary secretion RYR3;KCNMA1;SLC9A1;PRKG1;PLCB1;ITPR3;ADCY3;ATP1B3;PLCB4;ADCY6 68 5146 0.233291761 1.313154762 10.41028796 13 69 Amoebiasis VCL;COL11A1;CASP3;COL5A3;COL5A1;GNA11;CD14;RELA;RAB5A;PLCB1;ACTN2;LOC100511937;PLCB4 69 4020 0.236253407 1.226194622 17.80310116 21 118 Calcium signaling pathway MYLK;RYR3;PPP3CA;HTR4;EDNRA;CAMK2D;GNA11;PLCG1;PLCB1;ITPR3;TNNC1;TRPC1;CACNA1E;CACNA1G;ADCY3;CAMK4;PPID;PLCB4;P2RX5;PLCD3;GRIN2D 70 71 0.244883731 1.464429776 5.129707113 7 34 Fatty acid degradation CPT1A;ACSL4;ALDH2;ACADSB;ACSL3;ACADVL;ALDH3A2 71 4530 0.245761491 1.257398102 13.276889 16 88 Tight junction LOC396711;MYH9;OCLN;AKT1;GNAI1;EPB41L1;ACTN2;MYL9;PRKCI;CLDN11;SYMPK;YBX3;KRAS;EPB41L3;PATJ;CTNNA2 72 4115 0.251110255 1.345652689 7.845434408 10 52 p53 signaling pathway CASP3;CCNG1;GADD45A;CDKN1A;RRM2B;CD82;MDM4;PERP;GTSE1;SESN3 73 3410 0.259570478 1.567982456 3.470095988 5 23 Base excision repair POLL;MUTYH;FEN1;LIG1;POLD1 74 3030 0.259570478 1.567982456 3.470095988 5 23 DNA replication MCM4;POLA2;FEN1;LIG1;POLD1 75 4145 0.264764054 1.204118977 17.1996062 20 114 Phagosome CTSV;SCARB1;TFRC;C3;ITGA2;C1R;THBS1;TUBB;DYNC1H1;CD14;ITGB5;RAB5A;STX7;THBS2;LAMP2;THBS4;TUBB4B;SEC61G;ATP6V0C;RILP 76 620 0.26607168 1.472817133 4.37533842 6 29 Pyruvate metabolism DLD;ALDH2;GLO1;PDHB;LDHD;ALDH3A2 77 4340 0.269507218 1.411716172 5.280580852 7 35 Hedgehog signaling pathway BMP5;WNT16;CSNK1G3;WNT9A;WNT3A;WNT2B;CSNK1G2 78 4914 0.270042409 1.29505814 8.901550578 11 59 Progesterone-mediated oocyte maturation ARAF;FZR1;MAPK12;AKT1;GNAI1;PKMYT1;LOC100511937;ADCY3;RPS6KA2;KRAS;ADCY6 79 532 0.283250441 1.612010321 2.715727295 4 18 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate XYLT2;CHSY3;CHST14;B3GALT6 80 604 0.285826418 2.255319149 1.05611617 2 7 Glycosphingolipid biosynthesis - ganglio series ST3GAL1;B4GALNT1 81 240 0.289306398 1.268255475 9.052424317 11 60 Pyrimidine metabolism DPYD;NME7;AK3;POLR3H;RRM2B;POLA2;POLR1A;CMPK1;CTPS1;POLD1;UCK1 82 40 0.311269563 1.691803279 1.961358602 3 13 Pentose and glucuronate interconversions ALDH2;UGT1A6;ALDH3A2 83 410 0.319687196 1.50410509 2.866601034 4 19 beta-Alanine metabolism DPYD;SRM;ALDH2;ALDH3A2 84 650 0.319687196 1.50410509 2.866601034 4 19 Butanoate metabolism OXCT1;ALDH5A1;PDHB;BDH2 85 5213 0.320491531 1.316831683 5.582328329 7 37 Endometrial cancer ARAF;AKT1;SOS2;LOC100511937;KRAS;SOS1;CTNNA2 86 5144 0.342244784 1.25399449 6.638444499 8 44 Malaria MYD88;SDC4;THBS1;MET;SDC2;THBS2;THBS4;LRP1 87 4370 0.342244784 1.25399449 6.638444499 8 44 VEGF signaling pathway PPP3CA;MAPK12;AKT1;PLCG1;NFATC4;LOC100511937;KRAS;MAPKAPK2 88 5210 0.342244784 1.25399449 6.638444499 8 44 Colorectal cancer CASP3;ARAF;BCL2;AKT1;FOS;LOC100511937;MSH3;KRAS 89 4976 0.342244784 1.25399449 6.638444499 8 44 Bile secretion SCARB1;RXRA;SLC9A1;AQP1;NCEH1;ADCY3;ATP1B3;ADCY6 90 533 0.345606355 1.87888707 1.206989909 2 8 Glycosaminoglycan biosynthesis - keratan sulfate ST3GAL1;B3GNT2 91 4930 0.350669356 1.301736155 4.827959636 6 32 Type II diabetes mellitus SLC2A4;SOCS2;MTOR;CACNA1E;LOC100511937;CACNA1G 92 4610 0.37627727 1.175373134 8.75067684 10 58 Complement and coagulation cascades CD55;C3;PLAT;C1S;CD59;C1R;CFB;SERPING1;MASP1;CFI 93 4114 0.382707174 1.147578894 10.71203544 12 71 Oocyte meiosis PPP3CA;CAMK2D;MAPK12;AURKA;PPP2R5D;REC8;ITPR3;PKMYT1;ADCY3;RPS6KA2;ADCY6;PPP2R5E 94 300 0.387847235 2.816993464 0.452621216 1 3 Lysine biosynthesis AASS 95 430 0.403631961 1.610007014 1.357863648 2 9 Taurine and hypotaurine metabolism GGT5;CDO1 96 4974 0.406426276 1.153446719 7.996308147 9 53 Protein digestion and absorption KCNE3;COL11A1;DPP4;COL5A3;COL5A1;SLC1A5;ATP1B3;SLC36A1;SLC38A2 97 4062 0.409684127 1.085095343 18.70834359 20 124 Chemokine signaling pathway CXCR4;CXCL2;AKT1;RELA;GNAI1;VAV2;PLCB1;CSK;GNB3;GRK3;SOS2;LOC100511937;ADCY3;GSK3A;PLCB4;KRAS;GRK4;SOS1;ADCY6;PAK1 98 4670 0.423515399 1.096549805 12.97514152 14 86 Leukocyte transendothelial migration CXCR4;VCL;OCLN;MAPK12;GNAI1;VAV2;PLCG1;ACTN2;MYL9;THY1;CLDN11;LOC100511937;SIPA1;CTNNA2 99 510 0.425735459 1.160551349 6.185823283 7 41 N-Glycan biosynthesis DDOST;DOLK;NTMT1;MGAT5B;ALG6;DPM2;MGAT4A 100 4350 0.429425643 1.127483444 8.147181885 9 54 TGF-beta signaling pathway INHBA;FST;THBS1;BMPR2;BMP5;THBS2;EP300;THBS4;PITX2 101 260 0.429556003 1.252326218 3.31922225 4 22 "Glycine, serine and threonine metabolism" TDH;DLD;MAOB;SDS 102 4120 0.432352734 1.094004975 12.06989909 13 80 Ubiquitin mediated proteolysis FZR1;UBE2K;XIAP;KEAP1;PRPF19;RHOBTB1;UBE2Q1;UBE4A;UBE2F;CBL;UBE2G1;FBXO4;UBE2J2 103 5222 0.44140215 1.105258024 9.203298056 10 61 Small cell lung cancer RARB;RXRA;ITGA2;XIAP;BCL2;AKT1;RELA;ITGA6;LOC100511937;TRAF2 104 4320 0.442758309 1.300252207 2.413979818 3 16 Dorso-ventral axis formation SOS2;KRAS;SOS1 105 5219 0.449991726 1.173930921 4.37533842 5 29 Bladder cancer VEGFA;ARAF;CDKN1A;KRAS;VEGFB 106 4975 0.449991726 1.173930921 4.37533842 5 29 Fat digestion and absorption SCARB1;DGAT1;MTTP;AGPAT1;PLPP1 107 4972 0.463036334 1.083684143 9.354171794 10 62 Pancreatic secretion KCNMA1;SLC9A1;RAB11A;PLCB1;ITPR3;TRPC1;ADCY3;ATP1B3;PLCB4;ADCY6 108 565 0.465342429 1.18606862 3.470095988 4 23 Ether lipid metabolism PLA2G7;PLPP1;PAFAH1B2;CHPT1 109 480 0.465502299 1.126853377 5.43145459 6 36 Glutathione metabolism ANPEP;PGD;MGST1;SRM;RRM2B;GGT5 110 460 0.480273256 1.87745098 0.603494954 1 4 Cyanoamino acid metabolism GGT5 111 52 0.48459836 1.207025761 2.564853556 3 17 Galactose metabolism PGM1;GALK1;GAA 112 340 0.48459836 1.207025761 2.564853556 3 17 Histidine metabolism MAOB;ALDH2;ALDH3A2 113 3430 0.48459836 1.207025761 2.564853556 3 17 Mismatch repair MSH3;LIG1;POLD1 114 4664 0.488584989 1.0729634 7.543686931 8 50 Fc epsilon RI signaling pathway MAPK12;AKT1;VAV2;PLCG1;SOS2;LOC100511937;KRAS;SOS1 115 520 0.493568899 1.090184408 5.582328329 6 37 Amino sugar and nucleotide sugar metabolism GFPT1;PGM1;UAP1;GNPDA1;GALK1;LOC100524254 116 970 0.5002931 1.126436782 3.620969727 4 24 Aminoacyl-tRNA biosynthesis EPRS;VARS;HARS;FARSA 117 1040 0.511386167 1.251500273 1.659611125 2 11 Biosynthesis of unsaturated fatty acids SCD5;HACD1 118 830 0.521128117 1.055807249 5.733202067 6 38 Retinol metabolism DHRS4;DGAT1;RDH10;UGT1A6;RDH11;DHRS3 119 4977 0.524867944 1.126229508 2.715727295 3 18 Vitamin digestion and absorption SCARB1;CUBN;SLC5A6 120 534 0.524867944 1.126229508 2.715727295 3 18 Glycosaminoglycan biosynthesis - heparan sulfate / heparin GLCE;XYLT2;B3GALT6 121 4640 0.526869752 1.023669531 9.80679301 10 65 Hematopoietic cell lineage CD55;KIT;TFRC;CD59;ITGA2;KITLG;ANPEP;IL4R;CD14;ITGA6 122 5145 0.531560461 1.010401952 13.88038395 14 92 Toxoplasmosis IRAK1;MYD88;IL10RB;CASP3;MAPK12;XIAP;BCL2;AKT1;RELA;GNAI1;PPIF;TAB2;ITGA6;LOC100511937 123 4973 0.534214029 1.072484166 3.771843465 4 25 Carbohydrate digestion and absorption AMY2;AKT1;LOC100511937;ATP1B3 124 500 0.534214029 1.072484166 3.771843465 4 25 Starch and sucrose metabolism AMY2;PGM1;UGT1A6;GAA 125 4130 0.534214029 1.072484166 3.771843465 4 25 SNARE interactions in vesicular transport STX7;STX17;YKT6;BET1L 126 3008 0.535858234 1.023591285 7.845434408 8 52 Ribosome biogenesis in eukaryotes DKC1;NOL6;NAT10;GAR1;GNL3L;NXT2;REXO1;MDN1 127 5150 0.54807712 1.023513554 5.884075806 6 39 Staphylococcus aureus infection C3;C1S;C1R;CFB;MASP1;CFI 128 3050 0.54807712 1.023513554 5.884075806 6 39 Proteasome PSMC5;PSME3;PSMB6;PSMB5;PSMD3;PSMC3 129 3060 0.563339334 1.055532787 2.866601034 3 19 Protein export SEC63;SEC61G;SPCS3 130 5160 0.574255419 0.978224456 16.29436377 16 108 Hepatitis C SCARB1;OCLN;RXRA;ARAF;PSME3;MAPK12;AKT1;RELA;CDKN1A;SOS2;EIF3E;CLDN11;LOC100511937;TRAF2;KRAS;SOS1 131 10 0.574326281 0.993119488 6.034949545 6 40 Glycolysis / Gluconeogenesis DLD;PGM1;ALDH2;PGAM2;PDHB;ALDH3A2 132 4650 0.591172276 0.966725498 11.3155304 11 75 Natural killer cell mediated cytotoxicity PPP3CA;CASP3;ARAF;VAV2;PLCG1;NFATC4;SOS2;LOC100511937;KRAS;SOS1;PAK1 133 4630 0.59330304 0.965476917 17.50135368 17 116 Jak-STAT signaling pathway IL10RB;IL12RB2;IL4R;IL13RA1;SOCS2;AKT1;EP300;SOS2;STAM2;SOCS5;LOC100511937;SPRY4;CLCF1;SPRED3;SPRED2;CBL;SOS1 134 514 0.599851004 0.993153327 3.017474772 3 20 Other types of O-glycan biosynthesis UGT1A6;FUT4;MGAT5B 135 5212 0.62426081 0.937293729 7.392813192 7 49 Pancreatic cancer VEGFA;ARAF;AKT1;RELA;LOC100511937;KRAS;VEGFB 136 280 0.625578604 0.9375 5.280580852 5 35 "Valine, leucine and isoleucine degradation" OXCT1;DLD;ALDH2;ACADSB;ALDH3A2 137 4742 0.634298627 0.937704918 3.168348511 3 21 Taste transduction GNB3;ITPR3;ADCY6 138 250 0.634298627 0.937704918 3.168348511 3 21 "Alanine, aspartate and glutamate metabolism" GFPT1;ALDH5A1;GPT 139 5218 0.646347572 0.915227569 7.543686931 7 50 Melanoma ARAF;MET;AKT1;CDKN1A;LOC100511937;KRAS;PDGFA 140 5142 0.64652986 0.923666036 12.82426778 12 85 Chagas disease (American trypanosomiasis) IRAK1;MYD88;C3;MAPK12;GNA11;AKT1;RELA;GNAI1;FOS;PLCB1;LOC100511937;PLCB4 141 100 0.647167861 0.937806874 2.112232341 2 14 Steroid biosynthesis CYP2R1;LIPA 142 360 0.647167861 0.937806874 2.112232341 2 14 Phenylalanine metabolism MIF;MAOB 143 4614 0.647167861 0.937806874 2.112232341 2 14 Renin-angiotensin system THOP1;ANPEP 144 140 0.656924428 0.899835796 4.37533842 4 29 Steroid hormone biosynthesis CYP19A1;CYP19A3;UGT1A6;HSD17B8 145 4140 0.656924428 0.899835796 4.37533842 4 29 Regulation of autophagy PRKAA1;ULK1;ATG12;ATG4C 146 983 0.666626409 0.888093184 3.31922225 3 22 Drug metabolism - other enzymes DPYD;UGT1A6;UCK1 147 5216 0.666626409 0.888093184 3.31922225 3 22 Thyroid cancer RXRA;KRAS;TPR 148 270 0.68395408 0.864974106 4.526212159 4 30 Cysteine and methionine metabolism SRM;DNMT1;SDS;CDO1 149 4964 0.685247424 0.86541609 2.263106079 2 15 Proximal tubule bicarbonate reclamation AQP1;ATP1B3 150 5322 0.700345019 0.871431834 10.10854049 9 67 Systemic lupus erythematosus H3F3A;C3;C1S;C1R;SNRPD3;ACTN2;LOC100512448;LOC100521680;ELANE 151 5143 0.709451925 0.832694764 4.677085897 4 31 African trypanosomiasis MYD88;THOP1;PLCB1;PLCB4 152 4380 0.710256514 0.874646153 13.42776274 12 89 Osteoclast differentiation PPP3CA;TEC;MAPK12;AKT1;RELA;FOS;TAB2;LOC100511937;FHL2;TRAF2;CAMK4;MAP3K14 153 4520 0.713687272 0.842668863 6.940191976 6 46 Adherens junction VCL;MET;EP300;ACTN2;FARP2;CTNNA2 154 30 0.719888727 0.803366846 2.413979818 2 16 Pentose phosphate pathway PGD;PGM1 155 860 0.724894136 0.803044496 3.620969727 3 24 Porphyrin and chlorophyll metabolism HMOX1;EPRS;UGT1A6 156 380 0.733417813 0.802721088 4.827959636 4 32 Tryptophan metabolism MAOB;ALDH2;OGDHL;ALDH3A2 157 910 0.751260776 0.749590835 2.564853556 2 17 Nitrogen metabolism LOC100152714;CA12 158 4620 0.760193964 0.824797581 11.76815161 10 78 Toll-like receptor signaling pathway IRAK1;MYD88;SPP1;MAPK12;CD14;AKT1;RELA;FOS;TAB2;LOC100511937 159 4622 0.761785313 0.80174446 8.448929363 7 56 RIG-I-like receptor signaling pathway MAPK12;RELA;SIKE1;ATG12;TRAF2;DDX3X;RNF125 160 562 0.762744981 0.779879386 6.185823283 5 41 Inositol phosphate metabolism PLCG1;PLCB1;PLCB4;PIP4K2A;PLCD3 161 4122 0.770878581 0.703022876 1.357863648 1 9 Sulfur relay system TRMU 162 4330 0.774889305 0.732786885 3.922717204 3 26 Notch signaling pathway EP300;JAG1;DVL1 163 5140 0.778073915 0.785478548 8.599803101 7 57 Leishmaniasis IRAK1;MYD88;C3;MAPK12;RELA;FOS;TAB2 164 3015 0.78722221 0.765163996 7.543686931 6 50 mRNA surveillance pathway PPP2R5D;SMG5;SYMPK;CPSF7;NXT2;PPP2R5E 165 3020 0.804997591 0.661018581 2.866601034 2 19 RNA polymerase POLR3H;POLR1A 166 450 0.805523729 0.624727669 1.508737386 1 10 Selenocompound metabolism SCLY 167 511 0.805523729 0.624727669 1.508737386 1 10 Other glycan degradation MANBA 168 670 0.805523729 0.624727669 1.508737386 1 10 One carbon pool by folate ALDH1L2 169 4960 0.81718322 0.673770492 4.224464681 3 28 Aldosterone-regulated sodium reabsorption LOC100511937;ATP1B3;KRAS 170 630 0.834937485 0.562091503 1.659611125 1 11 Glyoxylate and dicarboxylate metabolism ACO2 171 603 0.834937485 0.562091503 1.659611125 1 11 Glycosphingolipid biosynthesis - globo series ST3GAL1 172 4621 0.846737713 0.659905341 5.733202067 4 38 NOD-like receptor signaling pathway MAPK12;XIAP;RELA;TAB2 173 770 0.85990869 0.510843731 1.810484863 1 12 Pantothenate and CoA biosynthesis DPYD 174 230 0.86383648 0.745424293 15.38912134 12 102 Purine metabolism PGM1;AK5;NME7;POLR3H;RRM2B;POLA2;ADCY3;PDE8A;POLR1A;PDE8B;ADCY6;POLD1 175 5416 0.892445679 0.622258772 7.543686931 5 50 Viral myocarditis LOC396711;CD55;MYH9;CASP3;DMD 176 4110 0.89817233 0.679792375 12.52252031 9 83 Cell cycle FZR1;GADD45A;CDKN1A;EP300;PRKDC;MCM4;PKMYT1;ORC4;ORC1 177 3320 0.907889781 0.621636463 9.052424317 6 60 PPAR signaling pathway RXRA;LPL;CPT1A;ACSL4;SCD5;ACSL3 178 350 0.909464037 0.487725041 3.771843465 2 25 Tyrosine metabolism MIF;MAOB 179 640 0.920678599 0.467266776 3.922717204 2 26 Propanoate metabolism ALDH2;ALDH3A2 180 760 0.927344089 0.374183007 2.413979818 1 16 Nicotinate and nicotinamide metabolism NMRK1 181 590 0.932454816 0.532958011 6.940191976 4 46 Arachidonic acid metabolism ALOX15;PTGES2;GGT5;LOC100518620 182 982 0.947610302 0.466393443 5.884075806 3 39 Drug metabolism - cytochrome P450 MGST1;MAOB;UGT1A6 183 4966 0.94768985 0.329969243 2.715727295 1 18 Collecting duct acid secretion ATP6V0C 184 591 0.955617198 0.311546841 2.866601034 1 19 Linoleic acid metabolism ALOX15 185 3440 0.955617198 0.311546841 2.866601034 1 19 Homologous recombination POLD1 186 3420 0.959642134 0.386139173 4.677085897 2 31 Nucleotide excision repair LIG1;POLD1 187 4514 0.960494093 0.598619804 15.53999508 10 103 Cell adhesion molecules (CAMs) OCLN;ALCAM;SDC4;ITGB8;SDC2;CADM3;ITGA6;CLDN11;CNTN1;L1CAM 188 980 0.969380195 0.361015786 4.978833374 2 33 Metabolism of xenobiotics by cytochrome P450 MGST1;UGT1A6 189 5323 0.973630521 0.499102511 11.01378292 6 73 Rheumatoid arthritis CTSV;ANGPT1;VEGFA;FOS;ATP6V0C;VEGFB 190 4940 0.982520224 0.319382745 5.582328329 2 37 Type I diabetes mellitus HSPD1;CPE 191 5020 0.985969333 0.223856209 3.922717204 1 26 Prion diseases EGR1 192 4672 0.986841587 0.301941876 5.884075806 2 39 Intestinal immune network for IgA production CXCR4;MAP3K14 193 2010 0.989907261 0.207153232 4.224464681 1 28 ABC transporters ABCA5 194 4623 0.994456425 0.259353709 6.789318238 2 45 Cytosolic DNA-sensing pathway RELA;POLR3H 195 4612 0.998526848 0.213899031 8.147181885 2 54 Antigen processing and presentation CTSV;PSME3 196 4060 0.999162671 0.439267887 24.44154566 12 162 Cytokine-cytokine receptor interaction IL10RB;CXCR4;KIT;IL12RB2;KITLG;IL4R;IL13RA1;MET;BMPR2;ACVR1B;CLCF1;ACKR3 197 4080 0.9997954 0.412926357 27.91164164 13 185 Neuroactive ligand-receptor interaction THRB;HTR4;EDNRA;GABBR1;GABRQ;S1PR3;ADCYAP1R1;GLRA1;CHRM4;GABRA1;P2RX5;GRIN2D;GRM3