{"text_format":"2","workbook":"xlsx","n_sheets":1,"sheets":["TXA vs Control"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"TXA vs Control","index":0,"n_rows":50,"n_cols":16,"rows_kept":50,"cut":false,"hidden":false,"merged":[]}
["research ID","country","publication type","year","follow-up period for mortality","type of sugery","on/off pump","transfusion protocol presented","IV/topical","continuous/bolus","dose","number of patients in TXA group","number of patients in control group","sample size","primary outcome","secondary outcome"]
["Abul Azm (2006)","Eygpt","original article",2006,"during hospital stay, average around 4 days","CABG+valve replacement","on","yes","topical","/","2 g ",50,50,{"$f":"L2+M2","v":100},"transfusion volume","postoperative blood loss, reoperation, mortality"]
["Ahn, S. W., et al. (2012) ","South Korea","original article",2006,"/","CABG","off","yes","IV","continuous+bolus","1g+200mg/h",38,38,{"$f":"L3+M3","v":76},"transfusion rate and volume","postoperative blood loss，adverse events"]
["Ali (2015)","Pakistan","original article",2015,"/","all kinds","on","no","topical","/","2.5g ",50,50,{"$f":"L4+M4","v":100},"/","postoperative blood loss"]
["Alizadeh Ghavidel, A., et al. (2014)","Iran","original article",2014,"/","CABG","on","yes","IV","continuous+bolus","0.5-2mg/kg/h in proportion to creatinne, prime solution 10mg/kg",100,100,{"$f":"L5+M5","v":200},"transfusion volume","postoperative blood loss, reoperation, adverse events"]
["Andreasen, J. J. and C. Nielsen (2004)","Demark","original article",2004,"30 days after operation","CABG","on","yes","IV","continuous+bolus","1.5 g+ 200mg/h ",23,23,{"$f":"L6+M6","v":46},"transfusion rate","postoperative blood loss, reoperation, mortality, adverse events"]
["Aoki, M., et al. (2012)","Japan","original article",2012,"during hospital stay","CABG","off","yes","topical","/","1g",50,50,{"$f":"L7+M7","v":100},"transfusion volume","postoperative blood loss, reoperation, mortality, adverse events"]
["Armellin, G., et al. (2001)","Italy","original article",2001,"during hospital stay","Avalve replacement","on","yes","IV","bolus","5g",143,140,{"$f":"L8+M8","v":283},"transfusion rate and volume","postoperative blood loss, reoperation, mortality, adverse events"]
["Baric (2007)","Croatia","original article",2007,"during hospital stay, average around 9 days","all kinds","both","yes","topical","/","2.5 g",97,96,{"$f":"L9+M9","v":193},"transfusion rate and volume","postoperative blood loss,mortality, adverse events"]
["Baric, D., et al. (2011)","Croatia","conference abstract",2011,"/","all kinds","on","no","topical","/","2.5g",20,20,{"$f":"L10+M10","v":40},"transfusion rate","postoperative blood loss"]
["Bonis (2000)","Italy","original article",2000,"during hospital stay","CABG ","on","yes","topical","/","1g",20,20,{"$f":"L11+M11","v":40},"transfusion rate","postoperative blood loss, reoperation, mortality, adverse events"]
["Brown, R. S., et al. (1997)","USA","original article",1997,"30 days after operation","CABG","on","yes","IV","continuous+bolus","15kg/mg+1mg/kg/h",60,30,{"$f":"L12+M12","v":90},"transfusion rate"," reoperation, mortality, adverse events"]
["Casati, V., et al. (2001)","Italy","original article",2001,"/","CABG","off","yes","IV","continuous+bolus","1g+400mg/h",20,20,{"$f":"L13+M13","v":40},"transfusion rate","postoperative blood loss, reoperation,  adverse events"]
["Casati, V., et al. (2004)","Italy","original article",2004,"during hospital stay, average around 8 days","CABG","on and off","yes","IV","continuous+bolus","1g+400mg/h+500mg in prime solution",52,50,{"$f":"L14+M14","v":102},"transfusion rate","reoperation, mortality, adverse events"]
["Chaudhary(2018) ","Pakistan","original article",2018,"during hospital stay","all kinds ","on","no","topical","/","2g ",50,50,{"$f":"L15+M15","v":100},"transfusion volume","postoperative blood loss, reoperation, mortality"]
["De Peppo, A. P., et al. (1995)","Italy","original article",1995,"/","all kinds","on","yes","IV","continuous+bolus","10mg/kg+1mg/kg/h ",15,15,{"$f":"L16+M16","v":30},"transfusion rate","postoperative blood loss, reoperation"]
["Diprose, P., et al. (2005)","UK","original article",2005,"during hospital stay","CABG+valve replacement","on","yes","IV","bolus","5g",60,60,{"$f":"L17+M17","v":120},"transfusion rate and volume","postoperative blood loss, reoperation, mortality, adverse events"]
["Esfandiari, B. R., et al. (2013)","Iran","original article",2013,"during hospital stay","CABG","on","yes","IV","bolus","prime solution 10mg/kg+1mg/kg",75,75,{"$f":"L18+M18","v":150},"transfusion rate and volume","postoperative blood loss, reoperation, mortality, adverse events"]
["Fawzy (2009) ","Canada","original article",2009,"during hospital stay, average around 8 days","CABG","on","yes","topical","/","1g ",19,19,{"$f":"L19+M19","v":38},"transfusion volume","postoperative blood loss, reoperation, mortality, adverse events"]
["Greiff, G., et al. (2012)","Norway","original article",2012,"during hospital stay, average around 9 days","CABG+valve replacement","on","yes","IV","continuous+bolus","10mg/kg, 1mg/kg/h",30,33,{"$f":"L20+M20","v":63},"transfusion volume","postoperative blood loss, reoperation, mortality"]
["Hardy, J. F., et al. (1998)","Canada","original article",1998,"during hospital stay","CABG","on","yes","IV","bolus","10g",43,45,{"$f":"L21+M21","v":88},"transfusion rate"," reoperation, mortality, adverse events"]
["Hashemi, J., et al. (2011)","Iran","original article",2011,"during hospital stay","CABG","on","yes","IV","bolus","1g prime solution+1g ",50,50,{"$f":"L22+M22","v":100},"transfusion rate","postoperative blood loss, reoperation, mortality, adverse events"]
["Hassani, E., et al. (2012)","Pakistan","original article",2011,"/","CABG","on","no","IV","bolus","10mg/kg",100,50,{"$f":"L23+M23","v":150},"transfusion volume","postoperative blood loss"]
["Hosseini, H., et al. (2014)","Iran","original article",2014,"/","CABG","off","yes","topical","/","1g",35,36,{"$f":"L24+M24","v":71},"/","postoperative blood loss, reoperation, adverse events"]
["Jares, M., et al. (2003). ","Czech","original article",2003,"during hospital stay","CABG","off","yes","IV","continuous+bolus","1g+200mg/h",22,25,{"$f":"L25+M25","v":47},"transfusion rate","postoperative blood loss, reoperation, mortality, adverse events"]
["Kamada, K., et al. (2001)","Japan","original article",2001,"/","CABG+valve replacement","on","yes","IV","bolus","50mg/kg×2 times",17,15,{"$f":"L26+M26","v":32},"/","postoperative blood loss"]
["Katsaros, D., et al. (1996)","USA","original article",1996,"during hospital stay","all kinds","on","yes","IV","bolus","10g",104,106,{"$f":"L27+M27","v":210},"transfusion rate","postoperative blood loss, reoperation, mortality, adverse events"]
["Kimenai, D. M., et al. (2016)","Netherlands","original article",2016,"during hospital stay","all kinds","on","yes","topical","/","2g",245,249,{"$f":"L28+M28","v":494},"transfusion rate and volume","postoperative blood loss, reoperation, mortality, adverse events"]
["Landymore, R. W., et al. (1997)","Canada","original article",1997,"during hospital stay","CABG","on","yes","IV","continuous+bolus","10mg/kg+1mg/kg/h",56,50,{"$f":"L29+M29","v":106},"transfusion volume","postoperative blood loss, mortality, adverse events"]
["Later, A. F. L., et al(2009)","Netherlands","original article",2009,"during hospital stay, average around 8 days","all kinds","on","yes","IV","continuous+bolus","1g+0.5g prime+400mg/h",99,103,{"$f":"L30+M30","v":202},"transfusion rate and volume","postoperative blood loss, reoperation, mortality, adverse events"]
["Maddali, M. M. and M. C. Rajakumar (2007)","oman","original article",2007,"during hospital stay","CABG","on","yes","IV","continuous+bolus","10mg/kg+1mg/kg/h",111,111,{"$f":"L31+M31","v":222},"transfusion volume","postoperative blood loss, reoperation, mortality, adverse events"]
["Mehr-Aein, A., et al. (2006)","Iran","original article",2006,"during hospital stay, average around 7 days","CABG","off","yes","IV","bolus","15mg/kg × 2 times",33,33,{"$f":"L32+M32","v":66},"transfusion rate","postoperative blood loss, reoperation, mortality, adverse events"]
["Mirmohammadsadeghi (2018)","Iran","original article",2018,"/","CABG","on","no","topical","/","1 g",62,63,{"$f":"L33+M33","v":125},"transfusion volume","postoperative blood loss"]
["Misfeld, M., et al. (1998)","Germay","original article",1998,"/","CABG","on","yes","IV","continuous+bolus","10mg/kg+1mg/kg/h",14,14,{"$f":"L34+M34","v":28},"transfusion rate","postoperative blood loss"]
["Murphy, G. J., et al. (2006)","Italy","original article",2006,"during hospital stay, average around 6 days","CABG","off","yes","IV","bolus","2g",50,50,{"$f":"L35+M35","v":100},"transfusion rate and volume","postoperative blood loss, reoperation, mortality, adverse events"]
["Myles, P. S., et al. (2017)","Australia","original article",2017,"30 days after operation","CABG","on and off","yes","IV","bolus","100mg/kg（n=1392）,50mg/kg（n=3329）",2311,2320,{"$f":"L36+M36","v":4631},"transfusion rate and volume","reoperation, mortality, adverse events"]
["Nouraei, M., et al. (2013)","Iran","original article",2013,"during hospital stay","CABG","on","yes","topical","/","2g",40,40,{"$f":"L37+M37","v":80},"transfusion volume","postoperative blood loss, reoperation, mortality, adverse events"]
["Pinosky, M. L., et al. (1997)","USA","original article",1997,"/","CABG+valve replacement","on","yes","IV","continuous+bolus","15mg/kg + 1mg/kg/h for 6h",20,19,{"$f":"L38+M38","v":39},"transfusion rate","postoperative blood loss"]
["pleym（2003）","Norway","original article",2003,"during hospital stay","CABG","on","yes","IV","bolus","30mg/kg",40,40,{"$f":"L39+M39","v":80},"transfusion rate and volume","postoperative blood loss, reoperation, mortality, adverse events"]
["Pugh, S. C. and A. K. Wielogorski (1995)","UK","original article",1995,"/","all kinds","on","yes","IV","bolus","2.5g+2.5g into prime solution",22,23,{"$f":"L40+M40","v":45},"/","postoperative blood loss,reoperation"]
["Rousou, J. A., et al. (1995)","USA","original article",1995,"during hospital stay","CABG","on  ","yes","IV","continuous+bolus","2g+continuous infusion 8g",206,209,{"$f":"L41+M41","v":415},"transfusion rate and volume","postoperative blood loss, reoperation, mortality, adverse events"]
["Shah, M. U. A., et al. (2015)","Pakistan","original article",2015,"/","all kinds","on","no","topical","/","2.5g",50,50,{"$f":"L42+M42","v":100},"/","postoperative blood loss"]
["Shi, J., et al. (2013)","China","original article",2013,"30 days after operation","CABG","on","yes","IV","continuous+bolus","10mg/kg bolus+10mg/kg/h",274,278,{"$f":"L43+M43","v":552},"transfusion rate and volume","postoperative blood loss, reoperation, mortality, adverse events"]
["Shore-Lesserson, L., et al. (1996)","USA","original article",1996,"during hospital stay","CABG+valve replacement","on  ","yes","IV","continuous+bolus","20mg/kg+2mg/kg/h",17,13,{"$f":"L44+M44","v":30},"transfusion rate","postoperative blood loss, reoperation, mortality, adverse events"]
["Speekenbrink, R. G. H., et al. (1995)","Netherlands","original article",1995,"during hospital stay","CABG","on","yes","IV","continuous+bolus","10mg/kg+1mg/kg/h",15,15,{"$f":"L45+M45","v":30},"transfusion rate and volume","postoperative blood loss, reoperation, mortality, adverse events"]
["Taghaddomi, R. J., et al. (2009)","Iran","original article",2009,"during hospital stay","CABG","off","yes","IV","continuous+bolus","1g+400mg/h",50,50,{"$f":"L46+M46","v":100},"transfusion rate","postoperative blood loss,adverse events"]
["Uozaki, Y., et al. (2001)","Japan","original article",2001,"/","CABG","on","yes","IV","bolus","50mg/kg",7,7,{"$f":"L47+M47","v":14},"/","postoperative blood loss,reoperation"]
["Wang, G., et al. (2012)","China","original article",2012,"during hospital stay, average around 7.6 days","CABG","off","yes","IV","continuous+bolus","1g+400mg/h",116,115,{"$f":"L48+M48","v":231},"transfusion rate and volume","postoperative blood loss, reoperation, mortality, adverse events"]
["Zabeeda, D., et al. (2002)","Isreal ","original article",2002,"during hospital stay","CABG","on","yes","IV","continuous+bolus","10mg/kg+1mg/kg/h",25,25,{"$f":"L49+M49","v":50},"transfusion rate","postoperative blood loss, mortality, adverse events"]
["Zhang, Y., et al. (2018)","China","original article",2018,"7 years after operation","CABG","on","yes","IV","continuous+bolus","10mg/kg + 10 mg/kg/h",100,102,{"$f":"L50+M50","v":202},"transfusion rate and volume","postoperative blood loss, reoperation, mortality, adverse events"]