GO_term	FDR	depletion_ratio	N_genes	N_alleles	total_mappable_length	definition
GO:0006412	3.16719918725e-39	0.518610098113	201	383	540248.5	translation (biological_process: The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome.) [GOC:go_curators]
GO:0004812	1.8079046224e-19	0.486483792457	34	140	210521.0	aminoacyl-tRNA ligase activity (molecular_function: Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.) [ISBN:0198506732]
GO:0006418	1.8079046224e-19	0.457157888977	30	115	184021.0	tRNA aminoacylation for protein translation (biological_process: The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis.) [GOC:ma]
GO:0003735	6.06513159179e-16	0.563915236406	152	192	249071.0	structural constituent of ribosome (molecular_function: The action of a molecule that contributes to the structural integrity of the ribosome.) [GOC:mah]
GO:0005840	2.80794309352e-15	0.55961246492	142	178	232685.0	ribosome (cellular_component: An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.) [ISBN:0198506732]
GO:0004386	9.99333123841e-15	0.749661440392	102	924	901659.5	helicase activity (molecular_function: Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix.) [GOC:mah, ISBN:0198506732]
GO:0006260	1.09793769411e-12	0.636250232756	41	258	296638.5	DNA replication (biological_process: The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.) [GOC:mah]
GO:0008026	4.96189507556e-12	0.720543975069	71	517	524887.0	ATP-dependent helicase activity (molecular_function: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.) [EC:3.6.1.3, GOC:jl]
GO:0043039	2.46098869718e-11	0.354900566166	10	33	68021.0	tRNA aminoacylation (biological_process: The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.) [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]
GO:0016876	5.54303675903e-11	0.329597750409	8	27	59926.0	ligase activity, forming aminoacyl-tRNA and related compounds (molecular_function: Catalysis of the joining of an amino acid and a nucleic acid (usually tRNA) or poly(ribitol phosphate), with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. The reaction forms an aminoacyl-tRNA or a related compound.) [EC:6.1.1, GOC:mah]
GO:0016773	6.51743853691e-11	0.615624682223	18	184	218644.0	phosphotransferase activity, alcohol group as acceptor (molecular_function: Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).) [GOC:jl]
GO:0003887	2.52349356375e-10	0.602000541082	19	157	190782.5	DNA-directed DNA polymerase activity (molecular_function: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.) [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
GO:0032549	5.1157502135e-08	0.35458326226	4	23	47451.0	ribonucleoside binding (molecular_function: Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.) [GOC:mah]
GO:0048037	5.20109281827e-08	0.55486658326	12	85	112064.0	cofactor binding (molecular_function: Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.) [ISBN:0198506732]
GO:0003899	5.66685557706e-08	0.569865791173	26	93	119384.0	DNA-directed RNA polymerase activity (molecular_function: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.) [EC:2.7.7.6]
GO:0005086	1.0728045901e-07	0.265229495897	3	12	33097.5	ARF guanyl-nucleotide exchange factor activity (molecular_function: Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.) [GOC:mah]
GO:0032012	1.0728045901e-07	0.265229495897	3	12	33097.5	regulation of ARF protein signal transduction (biological_process: Any process that modulates the frequency, rate or extent of ARF protein signal transduction.) [GOC:mah]
GO:0004813	1.58519364893e-07	0.138051727377	2	4	21196.0	alanine-tRNA ligase activity (molecular_function: Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).) [EC:6.1.1.7]
GO:0006419	1.58519364893e-07	0.138051727377	2	4	21196.0	alanyl-tRNA aminoacylation (biological_process: The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.) [GOC:mcc, ISBN:0716730510]
GO:0003918	1.64013090883e-07	0.32176232231	5	17	38650.0	DNA topoisomerase type II (ATP-hydrolyzing) activity (molecular_function: Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.) [PMID:8811192]
GO:0016459	1.69206852989e-07	0.198179214505	4	7	25839.0	myosin complex (cellular_component: A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.) [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
GO:0003774	1.69206852989e-07	0.198179214505	4	7	25839.0	motor activity (molecular_function: Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate.) [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
GO:0015986	1.94581647346e-07	0.23123858283	11	9	28472.0	ATP synthesis coupled proton transport (biological_process: The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.) [ISBN:0716731363]
GO:0003676	6.07643509094e-07	0.866127374857	308	2129	1798165.5	nucleic acid binding (molecular_function: Interacting selectively and non-covalently with any nucleic acid.) [GOC:jl]
GO:0030117	9.98214155277e-07	0.499992637772	11	48	70228.5	membrane coat (cellular_component: Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules.) [GOC:mah]
GO:0006886	1.05234460833e-06	0.733044335705	51	287	286409.5	intracellular protein transport (biological_process: The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.) [GOC:mah]
GO:0045261	1.31170826424e-06	0.231489609863	8	8	25281.0	proton-transporting ATP synthase complex, catalytic core F(1) (cellular_component: The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled.) [GOC:mah, PMID:10838056]
GO:0032040	1.38252322585e-06	0.21597438733	5	7	23710.0	small-subunit processome (cellular_component: A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.) [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]
GO:0004221	1.46367336812e-06	0.643373649633	20	127	144403.0	obsolete ubiquitin thiolesterase activity (molecular_function: OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.) [EC:3.1.2.15, GOC:jh2]
GO:0046933	2.77942132386e-06	0.331591972396	12	15	33092.0	proton-transporting ATP synthase activity, rotational mechanism (molecular_function: Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism.) [EC:3.6.3.14, TC:3.A.2.1.1]
GO:0030126	3.66534474229e-06	0.160332287525	3	4	18250.5	COPI vesicle coat (cellular_component: One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state.) [GOC:mah, PMID:11252894]
GO:0000398	4.53520381106e-06	0.337694391289	4	15	32494.0	mRNA splicing, via spliceosome (biological_process: The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.) [GOC:krc, ISBN:0198506732, ISBN:0879695897]
GO:0000105	5.78934883467e-06	0.294704161768	6	11	27305.0	histidine biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.) [GOC:go_curators]
GO:0006511	1.01651336356e-05	0.72224907051	36	212	214726.0	ubiquitin-dependent protein catabolic process (biological_process: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.) [GOC:go_curators]
GO:0003896	1.06781222564e-05	0.237721216452	4	7	21541.0	DNA primase activity (molecular_function: Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases.) [GOC:mah, GOC:mcc, ISBN:0716720094, PMID:26184436]
GO:0006364	1.09141965754e-05	0.49888799957	16	39	57187.0	rRNA processing (biological_process: Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.) [GOC:curators]
GO:0008104	1.77268645324e-05	0.511511362272	2	41	58636.0	protein localization (biological_process: Any process in which a protein is transported to, or maintained in, a specific location.) [GOC:ai]
GO:0046961	2.80842328192e-05	0.408485413837	13	20	35817.0	proton-transporting ATPase activity, rotational mechanism (molecular_function: Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.) [EC:3.6.3.14]
GO:0003989	6.86132999772e-05	0.324393176533	2	11	24806.0	acetyl-CoA carboxylase activity (molecular_function: Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.) [EC:6.4.1.2]
GO:0019867	0.000121156268079	0.248329087424	3	6	17675.0	outer membrane (cellular_component: The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.) [GOC:go_curators]
GO:0004086	0.000138746385336	0.223807166178	2	5	16343.0	obsolete carbamoyl-phosphate synthase activity (molecular_function: OBSOLETE. Catalysis of a reaction that results in the formation of carbamoyl phosphate.) [EC:6.3.4.16, EC:6.3.5.5, GOC:mah]
GO:0005681	0.000207503648549	0.393863659388	5	15	27860.0	spliceosomal complex (cellular_component: Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.) [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
GO:0006270	0.00036404972839	0.304046593254	3	8	19248.0	DNA replication initiation (biological_process: The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.) [ISBN:071673706X, ISBN:0815316194]
GO:0006904	0.000443913786168	0.493102216313	6	26	38572.0	vesicle docking involved in exocytosis (biological_process: The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis.) [GOC:jid]
GO:0005643	0.000616363352546	0.62417304929	8	59	69148.5	nuclear pore (cellular_component: Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.) [ISBN:0198547684]
GO:0000049	0.000661448480794	0.518629678468	8	29	40905.0	tRNA binding (molecular_function: Interacting selectively and non-covalently with transfer RNA.) [GOC:ai]
GO:0051082	0.000694335933675	0.675421753546	31	87	94228.0	unfolded protein binding (molecular_function: Interacting selectively and non-covalently with an unfolded protein.) [GOC:ai]
GO:0006396	0.000772019631997	0.775573822467	39	219	206565.0	RNA processing (biological_process: Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.) [GOC:mah]
GO:0006351	0.000846961538185	0.749027019156	36	165	161147.0	transcription, DNA-templated (biological_process: The cellular synthesis of RNA on a template of DNA.) [GOC:jl, GOC:txnOH]
GO:0042254	0.00101369608915	0.48101757118	9	21	31937.0	ribosome biogenesis (biological_process: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.) [GOC:ma]
GO:0046854	0.00104824354191	0.502198697965	3	24	34960.0	phosphatidylinositol phosphorylation (biological_process: The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.) [ISBN:0198506732]
GO:0048015	0.00104824354191	0.502198697965	3	24	34960.0	phosphatidylinositol-mediated signaling (biological_process: A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.) [GOC:bf, GOC:ceb, ISBN:0198506732]
GO:0004428	0.00104824354191	0.502198697965	3	24	34960.0	obsolete inositol or phosphatidylinositol kinase activity (molecular_function: OBSOLETE. Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol.) [GOC:hb]
GO:0016891	0.00107117930962	0.621726532866	4	54	63537.5	endoribonuclease activity, producing 5'-phosphomonoesters (molecular_function: Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.) [GOC:ai]
GO:0042765	0.00113801161843	0.0886817921408	2	1	8249.0	GPI-anchor transamidase complex (cellular_component: An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor.) [GOC:jl, GOC:rb, PMID:12802054]
GO:0019773	0.00185053023647	0.296628818018	6	6	14797.0	proteasome core complex, alpha-subunit complex (cellular_component: The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus.) [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]
GO:0004175	0.00185053023647	0.296628818018	6	6	14797.0	endopeptidase activity (molecular_function: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.) [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
GO:0006366	0.00185333117614	0.295769314031	2	6	14840.0	transcription from RNA polymerase II promoter (biological_process: The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).) [GOC:jl, GOC:txnOH, ISBN:0321000382]
GO:0031461	0.00192491420722	0.490930879384	4	20	29802.0	cullin-RING ubiquitin ligase complex (cellular_component: Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.) [PMID:15571813, PMID:15688063]
GO:0031625	0.00192491420722	0.490930879384	4	20	29802.0	ubiquitin protein ligase binding (molecular_function: Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.) [GOC:vp]
GO:0000166	0.00199057836649	0.862252962715	69	625	530250.5	nucleotide binding (molecular_function: Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.) [GOC:mah, ISBN:0198547684]
GO:0006426	0.00202128145118	0.341859269055	2	8	17119.0	glycyl-tRNA aminoacylation (biological_process: The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.) [GOC:mcc, ISBN:0716730510]
GO:0004820	0.00202128145118	0.341859269055	2	8	17119.0	glycine-tRNA ligase activity (molecular_function: Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).) [EC:6.1.1.14]
GO:0015934	0.00228101839825	0.460538172493	13	16	25415.0	large ribosomal subunit (cellular_component: The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).) [ISBN:0198506732]
GO:0005529	0.00240980762935	0.689778629581	4	80	84843.0	NOT_FOUND
GO:0009086	0.00248089762434	0.246142699653	2	4	11888.0	methionine biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.) [GOC:jl, ISBN:0198506732]
GO:0044267	0.00275229521843	0.703022806296	15	86	89488.0	cellular protein metabolic process (biological_process: The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.) [GOC:jl]
GO:0016833	0.00276146776892	0.210312248214	2	3	10435.0	oxo-acid-lyase activity (molecular_function: Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid.) [EC:4.1.3, GOC:jl]
GO:0006397	0.00281830221553	0.659556503609	12	60	66548.0	mRNA processing (biological_process: Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.) [GOC:mah]
GO:0008299	0.00291140224063	0.45382528436	8	15	24179.0	isoprenoid biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.) [ISBN:0198506732]
GO:0004828	0.00403881281713	0.16709367368	3	2	8756.0	serine-tRNA ligase activity (molecular_function: Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).) [EC:6.1.1.11]
GO:0006434	0.00403881281713	0.16709367368	3	2	8756.0	seryl-tRNA aminoacylation (biological_process: The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.) [GOC:mcc, ISBN:0716730510]
GO:0008565	0.00471047173277	0.753221596096	24	124	120430.0	protein transporter activity (molecular_function: Enables the directed movement of proteins into, out of or within a cell, or between cells.) [ISBN:0198506732]
GO:0051276	0.00479730431449	0.495396909731	3	18	26580.0	chromosome organization (biological_process: A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.) [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
GO:0030132	0.00484787299807	0.447338508105	4	13	21259.0	clathrin coat of coated pit (cellular_component: The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex.) [GOC:mah]
GO:0051539	0.0057888095095	0.586469928738	10	31	38668.0	4 iron, 4 sulfur cluster binding (molecular_function: Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.) [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
GO:0016772	0.00581383786141	0.651157252163	10	50	56172.0	transferase activity, transferring phosphorus-containing groups (molecular_function: Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).) [GOC:jl, ISBN:0198506732]
GO:0016114	0.00581383786141	0.262458015381	3	4	11149.0	terpenoid biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.) [GOC:ai]
GO:0006265	0.00611587788362	0.655049447315	7	51	56955.0	DNA topological change (biological_process: The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.) [ISBN:071673706X, ISBN:0935702490]
GO:0016070	0.00622178986152	0.619572780174	7	38	44867.0	RNA metabolic process (biological_process: The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.) [ISBN:0198506732]
GO:0003885	0.00640626903517	0.230429263976	2	3	9524.0	D-arabinono-1,4-lactone oxidase activity (molecular_function: Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+).) [EC:1.1.3.37, RHEA:23759]
GO:0006357	0.00699702884166	0.53230277792	6	21	28860.0	regulation of transcription from RNA polymerase II promoter (biological_process: Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.) [GOC:go_curators, GOC:txnOH]
GO:0004527	0.00735396804697	0.620264005356	5	38	44817.0	exonuclease activity (molecular_function: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.) [GOC:mah, ISBN:0198547684]
GO:0016651	0.0083444198929	0.484428914224	8	15	22651.5	oxidoreductase activity, acting on NAD(P)H (molecular_function: Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.) [GOC:ai]
GO:0004525	0.00999069784603	0.66101177284	3	47	52014.5	ribonuclease III activity (molecular_function: Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.) [PMID:11157775, PMID:15242644]
GO:0016740	0.0103896813201	0.615862613643	9	34	40386.0	transferase activity (molecular_function: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.) [ISBN:0198506732]
GO:0008283	0.0108426355093	0.408882432637	2	9	16102.0	cell proliferation (biological_process: The multiplication or reproduction of cells, resulting in the expansion of a cell population.) [GOC:mah, GOC:mb]
GO:0006370	0.0113998314534	0.243466641902	3	3	9014.0	7-methylguanosine mRNA capping (biological_process: Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.) [GOC:mah, PMID:9266685]
GO:0001510	0.0124947878503	0.451819041946	4	11	17810.0	RNA methylation (biological_process: Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor.) [GOC:hjd]
GO:0016818	0.0132523014626	0.744014520822	10	92	90457.0	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (molecular_function: Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.) [GOC:jl]
GO:0004579	0.0133971362587	0.323745841463	3	5	11298.0	dolichyl-diphosphooligosaccharide-protein glycotransferase activity (molecular_function: Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine.) [EC:2.4.1.119]
GO:0009098	0.0135360136063	0.403633962822	2	8	14499.0	leucine biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.) [GOC:ai]
GO:0003697	0.0136642256053	0.564278751591	3	22	28521.0	single-stranded DNA binding (molecular_function: Interacting selectively and non-covalently with single-stranded DNA.) [GOC:elh, GOC:vw, PMID:22976174]
GO:0004826	0.0139085370936	0.350800561079	2	6	12512.0	phenylalanine-tRNA ligase activity (molecular_function: Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).) [EC:6.1.1.20]
GO:0006432	0.0139085370936	0.350800561079	2	6	12512.0	phenylalanyl-tRNA aminoacylation (biological_process: The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.) [GOC:mcc, ISBN:0716730510]
GO:0006269	0.0147937006478	0.255216689163	2	3	8599.0	DNA replication, synthesis of RNA primer (biological_process: The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis.) [PMID:11395402]
GO:0006438	0.017455511563	0.52385882173	2	16	22343.0	valyl-tRNA aminoacylation (biological_process: The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.) [GOC:mcc, ISBN:0716730510]
GO:0004832	0.017455511563	0.52385882173	2	16	22343.0	valine-tRNA ligase activity (molecular_function: Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).) [EC:6.1.1.9, RHEA:10707]
GO:0004764	0.0178356543557	0.198194555234	2	2	7382.0	shikimate 3-dehydrogenase (NADP+) activity (molecular_function: Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+.) [EC:1.1.1.25]
GO:0005777	0.0203147957639	0.667757328962	7	42	46011.5	peroxisome (cellular_component: A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.) [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
GO:0006433	0.0222087773237	0.372188299857	2	6	11793.0	prolyl-tRNA aminoacylation (biological_process: The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.) [GOC:mah, ISBN:0716730510]
GO:0004827	0.0222087773237	0.372188299857	2	6	11793.0	proline-tRNA ligase activity (molecular_function: Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).) [EC:6.1.1.15]
GO:0008641	0.0256284188018	0.503545978175	3	13	18886.0	small protein activating enzyme activity (molecular_function: Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond.) [GOC:jl, GOC:mah]
GO:0004003	0.026523397318	0.789608519979	12	120	111174.5	ATP-dependent DNA helicase activity (molecular_function: Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.) [EC:3.6.1.3, GOC:jl]
GO:0016469	0.0266178188454	0.426334146351	4	8	13727.0	proton-transporting two-sector ATPase complex (cellular_component: A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.) [GOC:mah, ISBN:0716743663, PMID:16691483]
GO:0046034	0.0266178188454	0.426334146351	4	8	13727.0	ATP metabolic process (biological_process: The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.) [GOC:go_curators]
GO:0006563	0.0267473020496	0.410086708063	3	7	12487.0	L-serine metabolic process (biological_process: The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.) [CHEBI:17115, GOC:ai, GOC:jsg]
GO:0006544	0.0267473020496	0.410086708063	3	7	12487.0	glycine metabolic process (biological_process: The chemical reactions and pathways involving glycine, aminoethanoic acid.) [GOC:go_curators]
GO:0004372	0.0267473020496	0.410086708063	3	7	12487.0	glycine hydroxymethyltransferase activity (molecular_function: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.) [EC:2.1.2.1]
GO:0009228	0.0268393739373	0.606245389533	4	24	28960.0	thiamine biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.) [CHEBI:18385, GOC:jl, ISBN:0198506732]
GO:0030131	0.0269121530711	0.65745079134	9	35	38944.0	clathrin adaptor complex (cellular_component: A membrane coat adaptor complex that links clathrin to a membrane.) [GOC:mah]
GO:0046488	0.0288326385368	0.602626446186	3	23	27920.0	phosphatidylinositol metabolic process (biological_process: The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.) [CHEBI:28874, ISBN:0198506732]
GO:0016307	0.0288326385368	0.602626446186	3	23	27920.0	phosphatidylinositol phosphate kinase activity (molecular_function: Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate.) [EC:2.7.1.-, PMID:9759495]
GO:0016820	0.0294785962772	0.550622272847	7	16	21257.0	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (molecular_function: Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane.) [GOC:mah]
GO:0008897	0.0345784889772	0.136099740162	2	1	5375.0	holo-[acyl-carrier-protein] synthase activity (molecular_function: Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.) [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709]
GO:0009059	0.0345784889772	0.136099740162	2	1	5375.0	macromolecule biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.) [CHEBI:33694, GOC:mah]
GO:0019843	0.0350750193578	0.322404629074	8	4	9076.0	rRNA binding (molecular_function: Interacting selectively and non-covalently with ribosomal RNA.) [GOC:jl]
GO:0005694	0.036452099029	0.840406142685	20	202	175832.0	chromosome (cellular_component: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.) [ISBN:0198547684]
GO:0005815	0.0383919127324	0.68214202447	5	39	41824.0	microtubule organizing center (cellular_component: An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.) [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416]
GO:0000922	0.0383919127324	0.68214202447	5	39	41824.0	spindle pole (cellular_component: Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.) [GOC:clt]
GO:0051205	0.0417927094525	0.427548862285	4	7	11977.0	protein insertion into membrane (biological_process: The process that results in the incorporation of a protein into a biological membrane.  Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.) [GOC:ai]
GO:0006529	0.0417927094525	0.499807275594	4	11	16100.0	asparagine biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid.) [GOC:go_curators]
GO:0004066	0.0417927094525	0.499807275594	4	11	16100.0	asparagine synthase (glutamine-hydrolyzing) activity (molecular_function: Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.) [EC:6.3.5.4]
GO:0004326	0.0435250764359	0.148776917505	3	1	4917.0	tetrahydrofolylpolyglutamate synthase activity (molecular_function: Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).) [EC:6.3.2.17]
GO:0030130	0.0436188171853	0.537256050156	3	13	17701.0	clathrin coat of trans-Golgi network vesicle (cellular_component: A clathrin coat found on a vesicle of the trans-Golgi network.) [GOC:mah]
GO:0016455	0.0458567699634	0.62239967364	6	23	27033.0	NOT_FOUND
GO:0016592	0.0458567699634	0.62239967364	6	23	27033.0	mediator complex (cellular_component: A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.) [PMID:11454195, PMID:16168358, PMID:17870225]
GO:0003743	0.0458567699634	0.759006725351	20	70	67466.5	translation initiation factor activity (molecular_function: Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.) [ISBN:0198506732]
GO:0016624	0.0491276946404	0.639261206857	5	26	29753.0	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (molecular_function: Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide.) [GOC:jl]
GO:0004484	0.0580394678381	0.161558326716	2	1	4528.0	mRNA guanylyltransferase activity (molecular_function: Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue.) [EC:2.7.7.50]
GO:0016884	0.0594844229415	0.630486338405	6	22	25526.0	carbon-nitrogen ligase activity, with glutamine as amido-N-donor (molecular_function: Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction.) [PMID:12360532]
GO:0003684	0.0639818561656	0.78590748328	14	82	76327.0	damaged DNA binding (molecular_function: Interacting selectively and non-covalently with damaged DNA.) [GOC:jl]
GO:0048500	0.0664317744377	0.596113208575	5	17	20862.0	signal recognition particle (cellular_component: A complex of protein and RNA which facilitates translocation of proteins across membranes.) [GOC:mlg]
GO:0018279	0.0674605567784	0.252602245639	2	2	5792.0	protein N-linked glycosylation via asparagine (biological_process: The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.) [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]
GO:0004853	0.071152355223	0.396067191862	3	5	9235.0	uroporphyrinogen decarboxylase activity (molecular_function: Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2.) [EC:4.1.1.37]
GO:0008652	0.071705787017	0.741406992545	12	51	50321.0	cellular amino acid biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.) [ISBN:0198506732]
GO:0033178	0.071705787017	0.565891559685	7	14	18098.0	proton-transporting two-sector ATPase complex, catalytic domain (cellular_component: A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled.) [GOC:mah, PMID:10838056]
GO:0017056	0.0778634488045	0.59163431016	2	15	18547.0	structural constituent of nuclear pore (molecular_function: The action of a molecule that contributes to the structural integrity of the nuclear pore complex.) [GOC:mah]
GO:0045263	0.0819833429646	0.0	2	0	2799.0	proton-transporting ATP synthase complex, coupling factor F(o) (cellular_component: All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins.) [PMID:10838056]
GO:0006606	0.0832043153746	0.633940901573	2	20	23079.0	protein import into nucleus (biological_process: The directed movement of a protein from the cytoplasm to the nucleus.) [GOC:jl]
GO:0004809	0.0879679896719	0.415503864234	2	5	8803.0	tRNA (guanine-N2-)-methyltransferase activity (molecular_function: Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine.) [EC:2.1.1.32]
GO:0005663	0.0926729158407	0.57110072927	4	13	16652.0	DNA replication factor C complex (cellular_component: A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides.) [PMID:14614842, PMID:14646196, PMID:16172520]
GO:0003689	0.0926729158407	0.57110072927	4	13	16652.0	DNA clamp loader activity (molecular_function: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex.) [GOC:mah, GOC:vw, PMID:16082778]
GO:0000774	0.0976486066487	0.533890018515	3	10	13702.0	adenyl-nucleotide exchange factor activity (molecular_function: Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.) [GOC:kd]
GO:0042803	0.0976486066487	0.533890018515	3	10	13702.0	protein homodimerization activity (molecular_function: Interacting selectively and non-covalently with an identical protein to form a homodimer.) [GOC:jl]
GO:0003702	0.100497345318	0.665059108166	9	23	25299.0	obsolete RNA polymerase II transcription factor activity (molecular_function: OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription.) [GOC:jl]
GO:0006413	0.103406412599	0.788127052369	19	69	64045.5	translational initiation (biological_process: The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.) [ISBN:019879276X]
GO:0005730	0.107023835367	0.437312352564	2	5	8364.0	nucleolus (cellular_component: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.) [ISBN:0198506732]
GO:0016769	0.108445655066	0.811790044773	18	86	77498.0	transferase activity, transferring nitrogenous groups (molecular_function: Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor).) [GOC:jl, ISBN:0198506732]
GO:0015079	0.111765285399	0.697448316882	5	28	29368.5	potassium ion transmembrane transporter activity (molecular_function: Enables the transfer of potassium ions (K+) from one side of a membrane to the other.) [GOC:ai]
GO:0071805	0.111765285399	0.697448316882	5	28	29368.5	potassium ion transmembrane transport (biological_process: A process in which a potassium ion is transported from one side of a membrane to the other.) [GOC:mah]
GO:0000154	0.112448889312	0.390100575054	2	4	7501.0	rRNA modification (biological_process: The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically.) [GOC:curators]
GO:0000179	0.112448889312	0.390100575054	2	4	7501.0	rRNA (adenine-N6,N6-)-dimethyltransferase activity (molecular_function: Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor.) [ISBN:1555811337, PMID:10690410]
GO:0003723	0.112448889312	0.931168224359	247	873	685838.5	RNA binding (molecular_function: Interacting selectively and non-covalently with an RNA molecule or a portion thereof.) [GOC:mah]
GO:0000226	0.118030221489	0.752609159845	6	46	44712.0	microtubule cytoskeleton organization (biological_process: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.) [GOC:mah]
GO:0000287	0.119638127021	0.862828085178	27	170	144132.0	magnesium ion binding (molecular_function: Interacting selectively and non-covalently with magnesium (Mg) ions.) [GOC:ai]
GO:0016765	0.123575355183	0.540499542757	4	9	12181.0	transferase activity, transferring alkyl or aryl (other than methyl) groups (molecular_function: Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).) [GOC:jl, ISBN:0198506732]
GO:0000228	0.124268362873	0.670602703201	4	22	23999.0	nuclear chromosome (cellular_component: A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.) [GOC:dph, GOC:mah]
GO:0030127	0.126426428368	0.68706899783	4	25	26618.0	COPII vesicle coat (cellular_component: One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.) [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]
GO:0006164	0.127444044119	0.5676422924	4	11	14176.0	purine nucleotide biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.) [GOC:go_curators, ISBN:0198506732]
GO:0042558	0.127489846923	0.465897104364	2	6	9421.0	pteridine-containing compound metabolic process (biological_process: The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.) [GOC:jl, ISBN:0198506732]
GO:0005634	0.130442036185	0.941862489471	231	1220	947563.0	nucleus (cellular_component: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.) [GOC:go_curators]
GO:0032259	0.131323591237	0.712256068414	7	29	29785.0	methylation (biological_process: The process in which a methyl group is covalently attached to a molecule.) [GOC:mah]
GO:0005789	0.131543467586	0.708900187052	9	29	29926.0	endoplasmic reticulum membrane (cellular_component: The lipid bilayer surrounding the endoplasmic reticulum.) [GOC:mah]
GO:0003951	0.13639038633	0.594825399135	3	12	14758.0	NAD+ kinase activity (molecular_function: Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+).) [EC:2.7.1.23, RHEA:18632]
GO:0006614	0.13639038633	0.715858795743	8	30	30657.0	SRP-dependent cotranslational protein targeting to membrane (biological_process: The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.) [ISBN:0716731363]
GO:0016559	0.137902498171	0.190951736719	2	1	3831.0	peroxisome fission (biological_process: The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments.) [GOC:mah, PMID:11687502, PMID:14754507]
GO:0008649	0.144246301605	0.503070313743	3	7	10179.0	rRNA methyltransferase activity (molecular_function: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule.) [GOC:mah]
GO:0006423	0.146619728352	0.55780944932	2	9	11803.0	cysteinyl-tRNA aminoacylation (biological_process: The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.) [GOC:mcc, ISBN:0716730510]
GO:0004817	0.146619728352	0.55780944932	2	9	11803.0	cysteine-tRNA ligase activity (molecular_function: Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).) [EC:6.1.1.16]
GO:0006289	0.147784586708	0.777030475941	10	51	48014.0	nucleotide-excision repair (biological_process: A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).) [PMID:10197977]
GO:0005839	0.169084394124	0.754679611454	16	36	34896.0	proteasome core complex (cellular_component: A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex.) [GOC:rb, PMID:10806206]
GO:0004298	0.169084394124	0.754679611454	16	36	34896.0	threonine-type endopeptidase activity (molecular_function: Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.) [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
GO:0051603	0.169084394124	0.754679611454	16	36	34896.0	proteolysis involved in cellular protein catabolic process (biological_process: The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.) [GOC:ai, GOC:dph, GOC:tb]
GO:0004077	0.175795516055	0.425682923113	2	4	6874.0	biotin-[acetyl-CoA-carboxylase] ligase activity (molecular_function: Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)).) [EC:6.3.4.15]
GO:0009058	0.177826900549	0.927846986383	77	560	441517.0	biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.) [GOC:curators, ISBN:0198547684]
GO:0006888	0.18378114452	0.75621016061	9	35	33858.0	ER to Golgi vesicle-mediated transport (biological_process: The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.) [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]
GO:0005886	0.185002345992	0.328928104033	2	2	4448.0	plasma membrane (cellular_component: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.) [ISBN:0716731363]
GO:0016779	0.185062821333	0.876363243898	23	162	135228.0	nucleotidyltransferase activity (molecular_function: Catalysis of the transfer of a nucleotidyl group to a reactant.) [ISBN:0198506732]
GO:0006414	0.186645557482	0.697380317371	9	22	23077.5	translational elongation (biological_process: The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.) [GOC:ems]
GO:0008312	0.19247826629	0.691465667914	6	20	21159.0	7S RNA binding (molecular_function: Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP).) [GOC:jl, PMID:6181418]
GO:0005576	0.19247826629	0.76041117642	5	37	35595.0	extracellular region (cellular_component: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.) [GOC:go_curators]
GO:0005737	0.193925336939	0.939705187058	141	790	614994.5	cytoplasm (cellular_component: All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.) [ISBN:0198547684]
GO:0016757	0.196409860982	0.734856566373	3	27	26878.0	transferase activity, transferring glycosyl groups (molecular_function: Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).) [GOC:jl, ISBN:0198506732]
GO:0006338	0.206411820032	0.609474902451	2	11	13203.0	chromatin remodeling (biological_process: Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.) [GOC:jid, PMID:12697820]
GO:0007264	0.206411820032	0.59185768881	2	9	11124.0	small GTPase mediated signal transduction (biological_process: Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.) [GOC:mah]
GO:0042802	0.210141204362	0.463364119316	2	4	6315.0	identical protein binding (molecular_function: Interacting selectively and non-covalently with an identical protein or proteins.) [GOC:jl]
GO:0051087	0.218544242814	0.700973652136	6	20	20872.0	chaperone binding (molecular_function: Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.) [http://www.onelook.com]
GO:0006400	0.226927139044	0.667784904488	5	15	16432.0	tRNA modification (biological_process: The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.) [GOC:curators]
GO:0004637	0.232755449959	0.350142923714	2	2	4178.5	phosphoribosylamine-glycine ligase activity (molecular_function: Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate.) [EC:6.3.4.13, RHEA:17456]
GO:0006096	0.232929024433	0.879571873987	21	138	114774.0	glycolytic process (biological_process: The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.) [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
GO:0008898	0.245713181792	0.496091213461	2	5	7373.0	S-adenosylmethionine-homocysteine S-methyltransferase activity (molecular_function: Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine.) [EC:2.1.1.10, GOC:BHF, GOC:dph]
GO:0015992	0.259623405912	0.705964500357	6	18	18652.0	proton transport (biological_process: The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.) [GOC:jl]
GO:0004852	0.259623405912	0.483740190689	2	4	6049.0	uroporphyrinogen-III synthase activity (molecular_function: Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III.) [EC:4.2.1.75, RHEA:18968]
GO:0045226	0.259623405912	0.482384506014	2	4	6066.0	extracellular polysaccharide biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures.) [GOC:ai, GOC:go_curators]
GO:0008831	0.259623405912	0.482384506014	2	4	6066.0	dTDP-4-dehydrorhamnose reductase activity (molecular_function: Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH.) [EC:1.1.1.133, RHEA:21799]
GO:0005801	0.264565561191	0.623220398168	4	10	11738.0	cis-Golgi network (cellular_component: The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.) [ISBN:0198506732, ISBN:0815316194]
GO:0006914	0.268331338597	0.599681199606	2	8	9759.0	autophagy (biological_process: The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.) [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
GO:0008479	0.270985831316	0.54321987874	2	6	8080.0	queuine tRNA-ribosyltransferase activity (molecular_function: Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine.) [EC:2.4.2.29]
GO:0008616	0.270985831316	0.54321987874	2	6	8080.0	queuosine biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents.) [GOC:go_curators, ISBN:0198506732]
GO:0009231	0.278409217292	0.761399899425	10	27	25941.0	riboflavin biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).) [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
GO:0006465	0.284969449856	0.426054806855	3	3	5151.0	signal peptide processing (biological_process: The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell.) [GOC:mah, ISBN:0815316194]
GO:0003872	0.285222287997	0.686980510275	3	14	14908.0	6-phosphofructokinase activity (molecular_function: Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate.) [EC:2.7.1.11]
GO:0005945	0.285222287997	0.686980510275	3	14	14908.0	6-phosphofructokinase complex (cellular_component: A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known.) [GOC:mah, GOC:vw, ISBN:0198506732]
GO:0046912	0.285245773732	0.681540257348	3	14	15027.0	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer (molecular_function: Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.) [GOC:jl]
GO:0044262	0.285245773732	0.681540257348	3	14	15027.0	cellular carbohydrate metabolic process (biological_process: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.) [GOC:jl]
GO:0016614	0.285246954633	0.764748017262	6	28	26784.0	oxidoreductase activity, acting on CH-OH group of donors (molecular_function: Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.) [GOC:ai]
GO:0009113	0.288103904366	0.623556843333	3	9	10558.5	purine nucleobase biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.) [CHEBI:26386, GOC:go_curators, ISBN:0198506732]
GO:0015940	0.292084232166	0.539640088057	2	5	6778.0	pantothenate biosynthetic process (biological_process: The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.) [GOC:ai, ISBN:0721662544]
GO:0033897	0.298010129404	0.700570870877	2	15	15663.0	ribonuclease T2 activity (molecular_function: Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates.) [EC:3.1.27.1]