This PDF file includes:

• Fig. S1. SQSTM1’s UBA domain is required for the formation of the SQSTM1-ARNTL complex.
• Fig. S2. Analysis of ARNTL localization in ferroptosis.
• Fig. S3. Effects of gpx4 depletion on MAP1LC3B-II expression in Pfa1 cells.
• Fig. S4. Effects of MG-132 and desferrioxamine on protein expressions in HT1080 cells.
• Fig. S5. Effects of spautin-1, adaptaquin, liproxstatin-1, and chetomin on ferroptosis in vivo.
• Table S1. Reagent sources.

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