gene;Class;context;Phenotype(s) impacted;detection method;PROOF;fonction of protein;Background 1 (Strain);Info 1;Origin 1;Background 2 (Strain);info 2;origin2;Type of polymorphism;causative polymorphisms claimed;Ref genome;Positive allele;authors;patent
EAT1;OC;Brewery;ethyl acetate production;QTL mapping, ISA;RHA;Putative protein of unknown function;TMB 3000;spent sulfite liquor fermentation plant;spent sulfite liquor fermentation plant;NT112;Wine strain;Wine;INDEL;p.K179fs;S288c;TMB3000;Holt et al. - 2018;
SNF8;OC;Brewery;ethyl acetate production;QTL mapping, ISA;RHA;Component of the ESCRT-II complex;TMB 3000;spent sulfite liquor fermentation plant;spent sulfite liquor fermentation plant;NT112;Wine strain;Wine;nsSNP;p.Glu148*;S288c;TMB3000;Holt et al. - 2018;
FAS2;OC;Sake;Ethyl caproate production;Mutagenesis;Allele swapping;Fatty acid synthase;S288c;Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Gly1250Ser;S288c;NA;Akada et al. - 1999 ;NA
ABZ1;MET;Wine;Fermentation rate;QTL mapping, ISA;RHA;Para-aminobenzoate (PABA) synthase;EC1118 (59A);Industrial wine starter;Wine;S288c;Laboratory strain;Laboratory;nsSNP;p.Thr313Arg, p.Asn475Asp, p.Lys559Arg, p.Gln650Glu, p.Asn777Thr;S288c;59A;Ambroset et al. - 2011;NA
ABZ1;MET;Wine;Nitrogen assimilation;QTL mapping, ISA;RHA;Para-aminobenzoate (PABA) synthase;EC1118 (59A);Industrial wine starter;Wine;S288c;Laboratory strain;Laboratory;nsSNP;p.Thr313Arg, p.Asn475Asp, p.Lys559Arg, p.Gln650Glu, p.Asn777Thr;S288c;59A;Ambroset et al. - 2011;NA
SSD1;RTS;Laboratory;Ethanol tolerance;ALE;Complementation test;Translational repressor with a role in polar growth and wall integrity;W303 (W303-1A);Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.698Tyr;W303;NA;Avrahami-Moyal et al. - 2012 ;NA
UTH1;RTS;Laboratory;Ethanol tolerance;ALE;Complementation test;Mitochondrial inner membrane protein implicated in cell wall biogenesis, the oxidative stress response, life span during starvation, and cell death;W303 (W303-1A);Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Asp224Tyr;W303;NA;Avrahami-Moyal et al. - 2012 ;NA
CDC19;RTS;Bioethanol;Growth rate, High temparature growth;Comparative genomics;Allele swapping;Functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate;C3723;Longong fruit isolate;Nature;NA;NA;NA;sSNP;c.C1077T, c.T1167C;NA;C3723;Benjaphokee et al. - 2012;NA
ADH1;RTS;Bioethanol;Lignocellulosic hydrolysate tolerance,  5-hydroxymethylfurfural tolerance;Comparative genomics;Site-directed mutagenesis;Reduce acetaldehyde to ethanol;TMB300;Bioethanol production strain;Bioethanol;NA;NA;NA;nsSNP;p.Ser110Pro, p.117Leu, p.Tyr295Cys, p.Tyr295Ser, p.Tyr295Thr;S288c;TMB300;Boaz et al. -2008;US 8110387 B2
ARG81;MET;Wine;Nitrogen requirements;QTL mapping, BSA;RHA;Zinc finger transcription factor involved in arginine-responsive genes;T73 (MTF2029);Wine strain;Wine;4CAR1 (MTF1782);Wine strain;Wine;nsSNP;p.522Ala, p.Pro589Leu, p.Gln608His;S288c;MTF1782;Brice et al. - 2014 ;NA
BIO3;MET;Wine;Nitrogen requirements;QTL mapping, BSA;RHA;Involved in biotin synthesis;T73 (MTF2029);Wine strain;Wine;4CAR1 (MTF1782);Wine strain;Wine;nsSNP;p.Ser380Phe;S288c;MTF1782;Brice et al. - 2014 ;NA
GCN1;MET;Wine;Decreases nitrogen requirements;QTL mapping, BSA;RHA;Positive regulator of the Gcn2p kinase activity;T73 (MTF2029);Wine strain;Wine;4CAR1 (MTF1782);Wine strain;Wine;nsSNP;p.561Glu, p.Thr963Ala;S288c;MTF1782;Brice et al. - 2014 ;NA
MDS3;MET;Wine;Nitrogen requirements;QTL mapping, BSA;RHA;Component of the TOR pathway;T73 (MTF2029);Industrial wine starter;Wine;4CAR1 (MTF1782);Wine strain;Wine;nsSNP;p.8Thr, p.99Ser, p.Asp367Asn, p.Thr969Ile;S288c;MTF2029;Brice et al. - 2014 ;NA
WAR1;RTS;Wine;Sorbic acid tolerance;QTL mapping, ISA;Allele swapping;Transcription factor involved in acid response;EC1118 (59A);Industrial wine starter;Wine;S288c;Laboratory strain;Laboratory;nsSNP;p.Pro129Ser, p.Gly180Val, p.Phe268Ser, p.Pro731Thr, p.Asp893Gly;S288c;59A;Brion et al. - 2013 ;NA
MET10;OC;Wine;H2S production, SO2 production;Mutagenesis;Complementation test;Catalytic subunit of sulfite reductase;PDM;Industrial wine starter;Wine;NA;NA;NA;nsSNP;p.Trp841*, p.Trp59*, p.Leu606Phe, p.Glu929Lys, p.Thr990Ile, p.Thr997Ile;PDM;NA;Cordente et al. - 2009;NA
MET5;OC;Wine;H2S production, SO2 production;Mutagenesis;Complementation test;Catalytic subunit of sulfite reductase;PDM;Industrial wine starter;Wine;NA;NA;NA;nsSNP;p.Ala979Thr, p.Gly1115Asp, p. Glu1356Lys;PDM;NA;Cordente et al. - 2009;NA
YAP1;MET;Wine;Acetic acid production;Mutagenesis;Allele swapping;Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance;PDM;Industrial wine starter;Wine;NA;NA;NA;nsSNP;p.Gln573*;PDM;NA;Cordente et al. - 2013 ;NA
GDB1;MET;Wine;Fermentation rate;Allele Specific Expression;RHA;Glycogen debranching enzyme;DBVPG6765 (WE);Wine strain;Wine;DBVPG6044 (WA), YPS128 (NA), Y12 (SA);West African palm wine strain,  Soil beaneath strain, Sake strain;Palm wine, Nature, Sake;SNP or INDEL (5'/3'UTR);NA;NA;DBVPG6765 (WE);Cubillos et al. - 2016;NA
ALP1;MET;Wine;Nitrogen assimilation;QTL mapping, BSA;RHA;Arginine transporter;DBVPG6044 (WA);West African palm wine strain;Palm wine;DBVPG6765 (WE);Wine strain;Wine;NA;NA;NC;NA;Cubillos et al. - 2017;NA
ARO1;MET;Wine;Nitrogen assimilation;QTL mapping, BSA;RHA;Pentafunctional arom protein;DBVPG6044 (WA);West African palm wine strain;Palm wine;Y12 (SA);Sake strain;Sake;NA;NA;NC;NA;Cubillos et al. - 2017;NA
ASI2;MET;Wine;Nitrogen assimilation;QTL mapping, BSA;RHA;Subunit of the inner nuclear membrane Asi ubiquitin ligase complex;DBVPG6044 (WA);West African palm wine strain;Palm wine;DBVPG6765 (WE);Wine strain;Wine;NA;NA;NC;NA;Cubillos et al. - 2017;NA
CPS1;MET;Wine;Nitrogen assimilation;QTL mapping, Bulk RNA-seq;RHA;Vacuolar carboxypeptidase S;DBVPG6044 (WA);West African palm wine strain;Palm wine;Y12 (SA);Sake strain;Sake;NA;NA;NC;NA;Cubillos et al. - 2017;NA
LYP1;MET;Wine;Nitrogen assimilation;QTL mapping, Bulk RNA-seq;RHA;Lysine permease;DBVPG6044 (WA);West African palm wine strain;Palm wine;DBVPG6765 (WE);West African palm wine strain;Palm wine;NA;NA;NC;NA;Cubillos et al. - 2017;NA
PDC1;MET;Wine;Nitrogen assimilation;QTL mapping, Bulk RNA-seq;RHA;Major of three pyruvate decarboxylase isozymes;DBVPG6044 (WA);West African palm wine strain;Palm wine;YPS128 (NA);Soil beneath strain;Nature;NA;NA;NC;YPS128 (NA);Cubillos et al. - 2017;NA
MKT1;RTS;Laboratory;Lignocellulosic hydrolysate tolerance, 4-nitroquinoline tolerance, ;QTL mapping, ISA;Complementation test;Form a complex that may mediate posttranscriptional regulation of HO;RM11 (RM11-1a);Wine strain;Wine;S288c (BY4716);Laboratory strain;Laboratory;nsSNP;p.Asp30Gly;S288c;RM11-1a;Demogines et al. - 2008;NA
RAD5;RTS;Laboratory;Lignocellulosic hydrolysate tolerance, 4-nitroquinoline tolerance, MMS tolerance;QTL mapping, ISA;Site-directed mutagenesis;DNA-dependent ATPase involved in the error-free branch of post-replicative repair;RM11 (RM11-1a);Wine strain;Wine;S288c (BY4716);Laboratory strain;Laboratory;nsSNP;p.791Ile;S288c;BY4716;Demogines et al. - 2008;NA
MOT2;RTS;Laboratory;Osmolarity tolerance, salt stress tolerance;ALE;Allele swapping;Ubiquitin-protein ligase subunit of the CCR4-NOT complex;S288c;Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Gly230Asp;S288c;NA;Dhar et al. - 2011  ;NA
RDS2;RTS;Laboratory;Oxydative stress tolerance, peroxyde tolerance;QTL mapping, BSA, ISA;Site-directed mutagenesis;Transcription factor involved in regulating gluconeogenesis;YJM145;Clinical isolate strain;Clinical;S288c (S344);Laboratory strain;Laboratory;nsSNP;p.His251Asp;S288c;YJM145;Diezmann et Dietrich - 2011 ;NA
URE2;OC;Wine;Volatile thiols production;Comparative genomics;Allele swapping;Nitrogen catabolite repression transcriptional regulator;Sigma1278b;Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Gly182Glu;S288c;12597a;Dufour et al. - 2013 ;NA
VPS70;RTS;Bioethanol;Ethanol tolerance;QTL mapping, BSA;RHA;Protein of unknown function involved in vacuolar protein sorting;VR1 (VR1-5B);Bioethanol production strain;Bioethanol;S288c (BY4741);Laboratory strain;Laboratory;NA;NA;NA;VR1-5B;Duitama et al. - 2014;NA
AGP1;OC;Wine;Higher alcohols production, fusel acids production, Esters production;QTL mapping, ISA;RHA;Low-affinity amino acid permease with broad substrate range;4CAR1 (MTF2621);Wine strain;Wine;T73 (MTF2622);Industrial wine starter;Wine;nsSNP;p.7Pro, p.Gly24Glu, p.Asn142Ser, p.Ala316Val, p.Phe370Leu, p.Ile466Leu, p.Leu540Ile, p.Asp597Asn;S288c;MTF2621;Eder et al. 2018;NA
AGP2;OC;Wine;Medium chain fatty acids production, Ethyl esters production ;QTL mapping, ISA;RHA;Plasma membrane regulator of polyamine and carnitine transport;4CAR1 (MTF2621);Wine strain;Wine;T73 (MTF2622);Industrial wine starter;Wine;nsSNP;p.His256Tyr;S288c;MTF2621;Eder et al. 2018;NA
ALP1;OC;Wine;Higher alcohols production, Fusel acids production, Esters production;QTL mapping, ISA;RHA;Arginine transporter;4CAR1 (MTF2621);Wine strain;Wine;T73 (MTF2622);Industrial wine starter;Wine;nsSNP;p.Val126Ala;S288c;MTF2622;Eder et al. 2018;NA
FAS1;OC;Wine;Medium chain fatty acids production, Ethyl esters production ;QTL mapping, ISA;RHA;Beta subunit of fatty acid synthetase;4CAR1 (MTF2621);Wine strain;Wine;T73 (MTF2622);Industrial wine starter;Wine;nsSNP;p.1504Val, p.1715Val, p.1970Val;S288c;MTF2622;Eder et al. 2018;NA
ILV6;OC;Wine;Higher alcohols production, fusel acids production, Esters production;QTL mapping, ISA;RHA;Regulatory subunit of acetolactate synthase;4CAR1 (MTF2621);Wine strain;Wine;T73 (MTF2622);Industrial wine starter;Wine;nsSNP;p.Ser4Leu, p.Ala56Pro;S288c;MTF2621;Eder et al. 2018;NA
IXR1;OC;Wine;Esters production;QTL mapping, ISA;RHA;NA;4CAR1 (MTF2621);Wine strain;Wine;T73 (MTF2622);Industrial wine starter;Wine;nsSNP;p.Thr45Ala, p.Gln65*, p.Tyr93Phe, p.*104AlaThrThrThrThr, p.Met291Leu, p.GlnGln570*;NA;NA;Eder et al. 2018;NA
LEU9;OC;Wine;Esters production;QTL mapping, ISA;RHA;NA;4CAR1 (MTF2621);Wine strain;Wine;T73 (MTF2622);Industrial wine starter;Wine;nsSNP;p.Asp76His, p.Ser176Tyr;NA;NA;Eder et al. 2018;NA
MAE1;OC;Wine;Higher alcohols production, fusel acids production, Esters production;QTL mapping, ISA;RHA;Mitochondrial malic enzyme;4CAR1 (MTF2621);Wine strain;Wine;T73 (MTF2622);Industrial wine starter;Wine;nsSNP;p.605Ile;S288c;MTF2621;Eder et al. 2018;NA
NRG1;OC;Wine;Propanol production;QTL mapping, ISA;RHA;Transcriptional repressor;4CAR1 (MTF2621);Wine strain;Wine;T73 (MTF2622);Industrial wine starter;Wine;nsSNP;p.Pro129His, p.Thr156Ser;S288c;MTF2621;Eder et al. 2018;NA
RGS2;OC;Wine;Esters production;QTL mapping, ISA;RHA;NA;4CAR1 (MTF2621);Wine strain;Wine;T73 (MTF2622);Industrial wine starter;Wine;nsSNP;p.Asn99Tyr;NA;NA;Eder et al. 2018;NA
RGT1;OC;Wine;Esters production;QTL mapping, ISA;RHA;NA;4CAR1 (MTF2621);Wine strain;Wine;T73 (MTF2622);Industrial wine starter;Wine;nsSNP;p.Leu326Pro, p.Ile717Val, p.Pro722Ala, p.Ser729Asn;NA;NA;Eder et al. 2018;NA
SIR2;OC;Wine;Medium chain fatty acids production, Ethyl esters production ;QTL mapping, ISA;RHA;Conserved NAD+ dependent histone deacetylase of the Sirtuin family;4CAR1 (MTF2621);Wine strain;Wine;T73 (MTF2622);Industrial wine starter;Wine;nsSNP;p.Gln178His, p.201Ser;S288c;MTF2622;Eder et al. 2018;NA
SLN1;RTS;Laboratory;Activity of theCYC1-lacZ reporter gene;Mutagenesis;Mutant analysis;NA;S288c (JF1331);Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Pro1148Ser, p.Pro1196Leu;NA;JF1331;Fassler et al. - 1997;NA
FLO11;OC;Wine;Floating biofilm;QTL mapping, ISA;Complementation test;"GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation";MY138 (133d);Flor yeast derivative strain;Flor yeast;YNN295;Laboratory strain;NA;STR; del[-1313_-1203];YNN295;133d;Fidalgo et al. - 2006;NA
CYR1;RTS;Bakery;Fil phenotype stress tolerance in fermentation;Mutagenesis;Allele swapping;"Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling";M5;Industrial baker's starter;bakery;NA;NA;NA;nsSNP;p.Glu1682Lys;S288c;PVD1150;FR2779735A1;EP0967280 B1
GPR1;RTS;Bakery;Fil phenotype stress tolerance in fermentation;Mutagenesis;Allele swapping;NA;W303 (W303-1A);Laboratory strain;laboratory;NA;NA;NA;nsSNP;p.Tyr316*;NA;KL1;FR2779735A1;EP0967280 B1
ADH3;RTS;Bioethanol;Acetic acid tolerance;ALE;Site-directed mutagenesis;NA;CENPK;Laboratory strain;laboratory;NA;NA;NA;sSNP;c.T966G;NA;NA;González-Ramos et al. - 2016;NA
ASG1;RTS;Bioethanol;Acetic acid tolerance;ALE;Site-directed mutagenesis;NA;CENPK;Laboratory strain;laboratory;NA;NA;NA;sSNP;c.G1248T, c.1979G;NA;NA;González-Ramos et al. - 2016;NA
GIS4;RTS;Bioethanol;Acetic acid tolerance;ALE;Site-directed mutagenesis;NA;CENPK;Laboratory strain;laboratory;NA;NA;NA;sSNP;c.G1322C;NA;NA;González-Ramos et al. - 2016;NA
SKS1;RTS;Bioethanol;Acetic acid tolerance;ALE;Mutant analysis;NA;CENPK;Laboratory strain;laboratory;NA;NA;NA;nsSNP;P274L;NA;NA;González-Ramos et al. - 2016;NA
COX20;RTS;Bioethanol;Acetic acid tolerance;QTL mapping, ISA;RHA;Mitochondrial cytochrome C oxidase assembly gene;Y12 (SA);Sake strain;Sake;DBVPG6044 (WA);West African palm wine strain;Palm wine;nsSNP;p.Gln9Arg;S288c;Y12;Greetham et al. - 2014;NA
RCK2;RTS;Bioethanol;Osmolarity tolerance;QTL mapping, ISA;RHA;Kinase involved in response to oxidative and osmotic stress;YPS128 (NA);Soil beneath strain;Nature;DBVPG6765 (WE);Wine strain;Wine;nsSNP;p.113Gln, p.Ala456Ser;S288c;DBVPG6765 (WE);Greetham et al. - 2014;NA
HXT3;MET;Wine;Fructose uptake in fermentation;Comparative study;Allele swapping;Hexose carrier;Fermichamp;Industrial wine starter;Wine;NA;NA;NA;nsSNP;p.Thr200Ala, p.Ile209Val, p.Met324Ile, p.Leu388Met, p.Tyr389Trp, p.Ile392Val, p.Glu414Gln, p.Gly415Asn, p.Ile449Val, p.Leu471Ile;S288c;Fermichamp;Guillaume et al. - 2007;NA
ADE5,7;MET;Wine;Nitrogen assimilation, Amino acid assimilation, Methionine uptake;Large-scale hemizygosity analysis;RHA;Enzyme of the 'de novo' purine nucleotide biosynthetic pathway;PDM;Industrial wine starter;Wine;S288c (BY4741);Laboratory strain;Laboratory;nsSNP;p.107Ala;S288c;BY4741;Gutiérrez et al. - 2013;NA
ARO8;MET;Wine;Nitrogen assimilation, Amino acid assimilation, Methionine uptake;Large-scale hemizygosity analysis;RHA;Transaminase of the methionine salvage pathway;PDM;Industrial wine starter;Wine;S288c (BY4741);Laboratory strain;Laboratory;nsSNP;p.7Lys;S288c;BY4741;Gutiérrez et al. - 2013;NA
VBA3;MET;Wine;Nitrogen assimilation, Amino acid assimilation, Methionine uptake;Large-scale hemizygosity analysis;RHA;Enzyme of the 'de novo' purine nucleotide biosynthetic pathway;PDM;Industrial wine strain;Wine;S288c (BY4741);Laboratory strain;Laboratory;SNP or INDEL (5'/3'UTR);NA;NA;NA;Gutiérrez et al. - 2013;NA
MAL33;MET;Bakery;Maltose uptake, constitutive maltose uptake ;Mutagenesis;Site-directed mutagenesis;transcriptional activator (MALX1 et MALX2);NL67;Industrial baker's starter;Bakery;NA;NA;NA;nsSNP;p.Leu343Phe;S288c;NL67;Higgins et al. - 1999 ;NA
GAT1;MET;Laboratory;Growth rate, Growth rate on amonium;ALE;Backcross;Transcriptional activator of genes involved in nitrogen catabolite repression;S288c (FY4);Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Cys331Tyr;S288c;NA;Hong et Gresham - 2014 ;NA
LST4;MET;Laboratory;Growth rate,  Growth rate on amonium;ALE;Backcross;Protein possibly involved in a post-Golgi secretory pathway;S288c (FY4);Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Pro270Leu;S288c;NA;Hong et Gresham - 2014 ;NA
MEP2;MET;Laboratory;Growth rate, Growth rate on amonium;ALE;Backcross;Ammonium permease involved in regulation of pseudohyphal growth;S288c (FY4);Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Gly352Ala;S288c;NA;Hong et Gresham - 2014 ;NA
MET10;OC;Wine;H2S production, SO2 production;QTL mapping, ISA;Allele swapping;Catalytic subunit of sulfite reductase;EC1118 (E4);Industrial wine starter;Wine;Zymaflore F15 (F15);Industrial wine starter;Wine;nsSNP;p.Ala458Thr, p.Thr511Ile, p.Gly687Asp, p.Glu805Lys;S288c;E4;Huang et al. - 2014;NA
MET2;OC;Wine;H2S production;QTL mapping, ISA;Allele swapping;Part of the methionine biosynthetic pathway;Oenoferm M2 (M2);Industrial wine starter;Wine;Zymaflore F15 (F15);Industrial wine starter;Wine;nsSNP;p.301Gly;S288c;Oenoferm M2;Huang et al. - 2014;NA
MET5;OC;Wine;H2S production;QTL mapping, ISA;Allele swapping;Catalytic subunit of sulfite reductase;Oenoferm M2 (M2);Industrial wine starter;Wine;Zymaflore F15 (F15);Industrial wine starter;Wine;INDEL;p.Asn47Asp, p.Val288del;S288c;Oenoferm M2;Huang et al. - 2014;NA
SSK1;MET;Bioethanol;Glycerol-ethanol ratio;QTL mapping, BSA;Allele swapping;Involved in the High Osmolarity Pathway;K7 (CBS4C);Sake strain;Sake;Ethanol Red (ER7A);Bioethanol production strain;Bioethanol;INDEL; p.G329fsTer356;S288c;BS4C;Hubmann et al. - 2013A;NA
GPD1;MET;Bioethanol;Glycerol-ethanol ratio;QTL mapping, BSA;Allele swapping;GDPH : conversion of DHAP to glycerol 3-phosphate (Rate-controlling step in glycerol formation);K7 (CBS4C);Sake strain;Sake;Ethanol Red (ER7A);Bioethanol production strain;Bioethanol;nsSNP;p.Leu164Pro;S288c;26B;Hubmann et al. - 2013B;NA
HOT1;MET;Bioethanol;Glycerol-ethanol ratio;QTL mapping, BSA;RHA;transcription factor required for the response to osmotic stress of glycerol biosynthetic genes;K7 (CBS4C);Sake strain;Sake;Ethanol Red (ER7A);Bioethanol production strain;Bioethanol;nsSNP;p.Pro107Ser, p.His274Tyr;S288c;26B;Hubmann et al. - 2013B;NA
SMP1;MET;Bioethanol;Glycerol-ethanol ratio;QTL mapping, BSA;RHA;putative transcription factor involved in regulating glycerol production during the response to osmostress;K7 (CBS4C);Sake strain;Sake;Ethanol Red (ER7A);Bioethanol production strain;Bioethanol;nsSNP;p.Arg110Gln, p.Pro269Gln;S288c;26B;Hubmann et al. - 2013B;NA
DAL1;MET;Laboratory;Growth on allantoin ;QTL mapping, ISA;RHA;Allantoinase;DBVPG6044 (WA);West African palm wine strain;Palm wine;DBVPG6765 (WE), YPS128 (NA), Y12 (SA);Wine strain, Soil beneath strain, Sake strain;Wine, Nature, Sake;nsSNP;p.Pro139Ser;S288c;DBVPG6044;Ibstedt et al. - 2014 ;NA
DAL4;MET;Laboratory;Growth on allantoin ;QTL mapping, ISA;RHA;Allantoin permease;DBVPG6044 (WA);West African palm wine strain;Palm wine;DBVPG6765 (WE), YPS128 (NA), Y12 (SA);Wine strain, Soil beneath strain, Sake strain;Wine, Nature, Sake;nsSNP;p.Arg401*;S288c;DBVPG6044;Ibstedt et al. - 2014 ;NA
PUT4;MET;Laboratory;Growth rate,  Growth rate on proline;QTL mapping, ISA;RHA;Proline permease;DBVPG6044 (WA);West African palm wine strain;Palm wine;DBVPG6765 (WE), YPS128 (NA), Y12 (SA);Wine strain, Soil beneath strain, Sake strain;Wine, Nature, Sake;SNP or INDEL (5'/3'UTR);c.-911G>C, c.-726G>C, c.-429T>C, -478A, c.99C>T,  c.702C>T, c.1536T>C;S288c;DBVPG6044 (WA);Ibstedt et al. - 2014 ;NA
MPR1;RTS;Bakery;Oxydative stress tolerance;Mutagenesis;Allele swapping;L-azetidine-2-carboxylic acid acetyltransferase;3346;NA;NA;NA;NA;NA;nsSNP;p.Phe65Leu;S288c;3346;Iinoya et al. - 2009, Sasano et al. - 2012  ;NA
FAS2;MET;Sake;Acetic acid production;Mutagenesis;Complementation test;Alpha subunit of fatty acid synthetase;S288c;Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Gly1250Ser;S288c;S288c;Inokoshi et al. - 1994;NA
AGP1;MET;Wine;Nitrogen assimilation, Amino acid assimilation;QTL mapping, ISA;RHA;amino acid permease involved in the uptake of several amino acids;DBVPG6765 (WE);Wine strain;Wine;Y12 (SA);Sake strain;Sake;nsSNP;p.Leu7Pro, p.Gly24Glu, p.Gln92arg, p.Ala530Ser, p.Asp597Asn;S288c;DVBPG6765;Jara et al. - 2014 ;NA
ASI1;MET;Wine;Nitrogen assimilation, Amino acid assimilation, Serine, threonine and glutamine uptake;QTL mapping, ISA;RHA;Subunit of the nuclear inner membrane Asi ubiquitin ligase complex;DBVPG6765 (WE);Wine strain;Wine;Y12 (SA);Sake strain;Sake;nsSNP;p.Lys550Glu, p.Thr557Ile;S288c;DBVPG6765 (WE);Jara et al. - 2014 ;NA
GLT1;MET;Wine;Nitrogen assimilation, Amino acid assimilation, Glutamic and aspartic acid uptake;QTL mapping, ISA;RHA;glutamate synthase that synthesizes glutamate from glutamine;DBVPG6765 (WE);Wine strain;Wine;Y12 (SA);Sake strain;Sake;nsSNP;p.Gly65Glu, p.Asp321Asn, p.Lys679Arg, p.Gly1988Asp;S288c;Y12;Jara et al. - 2014 ;NA
MTH1;MET;Laboratory;Glucose uptake;ALE;Mutant analysis;Negative regulator of the glucose-sensing signal transduction pathway;S288c;Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Gln338*;S288c;NA;Kvitek et Sherlock - 2011 ;NA
BUL2;MET;Laboratory;Chronological life span;QTL mapping, ISA;Allele swapping;Component of an ubiquitin ligase complex involved in trafficking of amino acid permeases;S288c;Laboratory strain;Laboratory;RM11 (RM11-1a);Wine strain;Wine;nsSNP;p.883Leu;S288c;S288c;Kwan et al. - 2011 ;NA
BUL2;MET;Laboratory;Nitrogen assimilation, Amino acid assimilation;QTL mapping, ISA;Allele swapping;Component of an ubiquitin ligase complex involved in trafficking of amino acid permeases;S288c;Laboratory strain;Laboratory;RM11 (RM11-1a);Wine strain;Wine;nsSNP;p.883Leu;S288c;S288c;Kwan et al. - 2011 ;NA
CDC28;OC;Laboratory;Cell morphology;Comparative genomics, QTL mapping;RHA;Cyclin-dependent kinase that regulates polarization during cell division;NCYC110;Ivory Coast strain;Nature;YPS606;Bark oak tree strain;Nature;nsSNP;p.Ser79Phe;S288c;NCYC110;Lee et al. - 2011;NA
AMN1;OC;Laboratory;Non-sexual cell aggregation;QTL mapping, ISA;Site-directed mutagenesis;Negative regulator of the mitotic exit network in daughter cells;YL1C;Laboratory strain;Laboratory;S288c (YH1A);Laboratory strain;Laboratory;nsSNP;p.Val368Asp;S288c;YL1C;Li et al. - 2013 ;NA
RGA1;OC;Laboratory;Non-sexual cell aggregation;QTL mapping, ISA;Site-directed mutagenesis;GTPase-activating protein for polarity-establishment protein Cdc42p;YL1C;Laboratory strain;Laboratory;S288c (YH1A);Laboratory strain;Laboratory;nsSNP;p.358Pro, p.Ile415Phe, p.Tyr658Ser, p.Val866Ala;S288c;YL1C;Li et al. - 2013 ;NA
MET10;OC;Wine;H2S production;Comparative genomics;Allele swapping;Catalytic subunit of sulfite reductase;UCD932;Wine strain;Wine;NA;NA;NA;nsSNP;p.Thr662Lys;S288c;UCD932;Linderholm et al. - 2010;NA
ERG8;MET;Aroma production;Ergosterol production;Comparative genomics;Plasmidic overexpression;Phosphomevalonate kinase that acts in the biosynthesis of isoprenoids and sterols;CENPK;Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Gly49E, p.Ser75Thr, p.Ala192Ser, p.Asp247Asn;S288c;CEN.PK;Madsen et al. - 2011 ;NA
ERG9;MET;Aroma production;Ergosterol production;Comparative genomics;Plasmidic overexpression;Involved in the sterol biosynthesis pathway;CENPK;Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Gly286Ser;S288c;CEN.PK;Madsen et al. - 2011 ;NA
MSB2;MET;Wine;Fermentation rate;QTL mapping, ISA;RHA;Mucin family member involved in various signaling pathways;BO213 (SB);Industrial wine starter;Wine;Zymaflore VL1 (GN);Industrial wine starter;Wine;nsSNP;p.Ser529Phe;S288c;GN;Martí-Raga et al. - 2017;NA
PDR1;MET;Wine;Fermentation rate;QTL mapping, ISA;RHA;Transcription factor that regulates the pleiotropic drug response;BO213 (SB);Industrial wine starter;Wine;Zymaflore VL1 (GN);Industrial wine starter;Wine;nsSNP;p.His438Tyr, p.Ser955Leu, p.Asn1020Lys;S288c;SB;Martí-Raga et al. - 2017;NA
PMA1;MET;Wine;Fermentation rate;QTL mapping, ISA;RHA;Plasma membrane P2-type H+-ATPase;BO213 (SB);Industrial wine starter;Wine;Zymaflore VL1 (GN);Industrial wine starter;Wine;nsSNP;p.His54Gln, p.Leu74Pro, p.Leu176Met, p.Asp200Glu, p.Gln283Arg, p.Val290Leu, p.LysGln431IleGlu, p.Asp718Asn, p.Glu875Gln;S288c;SB;Martí-Raga et al. - 2017;NA
VMA13;MET;Wine;Fermentation rate;QTL mapping, ISA;RHA;Subunit H of the V1 peripheral membrane domain of V-ATPase;BO213 (SB);Industrial wine starter;Wine;Zymaflore VL1 (GN);Industrial wine starter;Wine;nsSNP;p.Asp120Gly;S288c;GN;Martí-Raga et al. - 2017;NA
ASP1;MET;Wine;Acetic acid production;QTL mapping, ISA;Allele swapping;Cytosolic L-asparaginase, involved in asparagine catabolism;BO213 (SB);Industrial wine starter;Wine;Zymaflore VL1 (GN);Industrial wine starter;Wine;nsSNP;p.142Asp;S288c;GN;Marullo et al. - 2007 ;NA
ASP1;MET;Wine;Nitrogen assimilation, Amino acid assimilation, Asparagine uptake;QTL mapping, ISA;Allele swapping;Cytosolic L-asparaginase, involved in asparagine catabolism;BO213 (SB);Industrial wine starter;Wine;Zymaflore VL1 (GN);industrial wine starter;Wine;nsSNP;p.142Asp;S288c;GN;Marullo et al. - 2007 ;NA
PAD1;OC;Wine;Phenolic off flavour production;QTL mapping, ISA;Mutant analysis;NA;BO213 (SB);Industrial wine starter;Wine;Zymaflore VL1 (GN);industrial wine starter;Wine;nsSNP;p.Asp213Gly;NA;GN;Marullo et al. - 2007 ;NA
OYE2;RTS;Wine;Temperature tolerance, Ethanol accumulation capacity;QTL mapping, BC;RHA;oxydoreductase involved in cell dead;Zymaflore F10 (G-1A);Wine strain;Wine;BO213 (B-1A);Industrial wine starter;Wine;INDEL;p.Ser77fsTer95;S288c;F10;Marullo et al. In press;NA
VHS1;RTS;Wine;Temperature tolerance, Ethanol accumulation capacity;QTL mapping, BC;RHA;MAP kinase;Zymaflore F10 (G-1A);Industrial wine starter;Wine;BO213 (B-1A);Industrial wine starter;Wine;nsSNP;p.Tyr372*;S288c;BO213 (B-1A);Marullo et al. In press;NA
CUP2;RTS;Bioethanol;Acetic acid tolerance;QTL mapping, BSA;RHA;NA;Ethanol Red (ER18);Bioethanol production strain;Bioethanol;JT22689;Wine strain;Wine;nsSNP;p.Ile121Val, p.Ala166Val;NA;JT22689;Meijnen et al. - 2016;NA
DOT5;RTS;Bioethanol;Acetic acid tolerance;QTL mapping, BSA;;NA;Ethanol Red (ER18);Bioethanol production strain;Bioethanol;JT22689;Wine strain;Wine;nsSNP;p.Thr9Ala, p.Pro155Ser;NA;JT22689;Meijnen et al. - 2016;NA
GLO1;RTS;Bioethanol;Acetic acid tolerance;QTL mapping, BSA;RHA;NA;Ethanol Red (ER18);Bioethanol production strain;Bioethanol;JT22689;Wine strain;Wine;nsSNP;p.His322Tyr;NA;JT22689;Meijnen et al. - 2016;NA
HAA1;RTS;Bioethanol;Acetic acid tolerance;QTL mapping, BSA;RHA;NA;Ethanol Red (ER18);Bioethanol production strain;Bioethanol;JT22689;Wine strain;Wine;nsSNP;p.Ser505Asn;NA;JT22689;Meijnen et al. - 2016;NA
VMA7;RTS;Bioethanol;Acetic acid tolerance;QTL mapping, BSA;RHA;NA;Ethanol Red (ER18);Bioethanol production strain;Bioethanol;JT22689;Wine strain;Wine;SNP or INDEL (5'/3'UTR);c.-291A, c.-139A, c.-110A, c.-67T, c.-61T;NA;JT22689;Meijnen et al. - 2016;NA
PDR1;MET;Sake;Fermentation rate;Mutagenesis;Allele swapping;Transcription factor that regulates the pleiotropic drug response;K1001;Industrial sake starter;Sake;NA;NA;NA;nsSNP;p.Met308Ile;S288c;K1001;Mizoguchi et al. - 2002;NA
PDR3;MET;Sake;Fermentation rate;Mutagenesis;Allele swapping;Transcriptional activator of the pleiotropic drug resistance network;K1001;Industrial sake starter;Sake;NA;NA;NA;nsSNP;p.Leu950Ser, p.Gly948Asp, p.Gly957Asp;S288c;K1001;Mizoguchi et al. - 2002;NA
MET2;OC;Wine;H2S production, SO2 production, Acetaldehyde production;QTL mapping;Allele swapping;Part of the methionine biosynthetic pathway;JN10;Wine strain;Wine;JN17;Wine strain;Wine;nsSNP;p.301Gly;S288c;JN17;Noble et al. - 2015;WO2013111091 A2
SKP2;OC;Wine;H2S production, SO2 production, Acetaldehyde production;QTL mapping;RHA;Involved in regulating protein levels of sulfur metabolism enzymes;JN10;Wine strain;Wine;JN17;Wine strain;Wine;nsSNP;p.350Ile, p.Thr357Ile;S288c;JN17;Noble et al. - 2015;WO2013111091 A2
GPA1;OC;Laboratory;Cell morphology;QTL mapping, ISA;Allele swapping;Subunit of the G protein involved in pheromone response;RM11 (YEF1946);Wine strain;Wine;S288c (BY4716);Laboratory strain;Laboratory;nsSNP;p.469Ile;S288c;BY4716;Nogami et al. - 2007 ;NA
PUT4;MET;Brewery;Nitrogen assimilation, Amino acid assimilation,  Proline uptake;Mutagenesis;NA;Proline permease;BH422 ;Industrial ale beer starter;Brewery;NA;NA;NA;nsSNP;p.Tyr9Arg, p.Tyr34Arg, p.Tyr35Arg, p.Tyr60Arg, p.Tyr68Arg, p.Tyr71Arg, p.Tyr93Arg, p.Tyr105Arg, p.Tyr107Arg;BH422;BH422 ;Omura et al. - 2005;NA
ADE1;RTS;Wine;Ethanol accumulation capacity;QTL mapping, BSA;RHA;Required for 'de novo' purine nucleotide biosynthesis;CBS1585 (Seg5);Sake strain;Sake;S288c (BY710);Laboratory strain;Laboratory;SNP or INDEL (5'/3'UTR);c.-148C>T;S288c;Seg5;Pais et al. - 2013;NA
KIN3;RTS;Wine;Ethanol accumulation capacity;QTL mapping, BSA;RHA;Nonessential serine/threonine protein kinase;CBS1585 (Seg5);Sake strain;Sake;S288c (BY710);Laboratory strain;Laboratory;SNP or INDEL (5'/3'UTR);c.-244G>A;S288c;Seg5;Pais et al. - 2013;NA
IRA1;RTS;Laboratory;Growth rate, High temparature growth;ALE, QTL mapping, BSA;RHA;GTPase activating protein in the RAS/cAMP signaling pathway;YPS128 (NA);Soil beneath strain;Nature;DBVPG6044 (WA);West African palm wine strain;Palm wine;nsSNP;p.Val2935Met, p.2651Val, p.Ala1246Ser;NA;YPS128;Parts et al. - 2011;NA
IRA2;RTS;Laboratory;Growth rate, High temparature growth;ALE, QTL mapping, BSA;RHA;GTPase activating protein in the RAS/cAMP signaling pathway;YPS128 (NA);Soil beneath strain;Nature;DBVPG6044 (WA);West African palm wine strain;Palm wine;NA;NA;NA;YPS128;Parts et al. - 2011;NA
SSU1;MET;Wine;Fermentation rate;QTL mapping, ISA;RHA;NA;BO213 (SB);Wine strain;Wine;Zymaflore VL1 (GN);Wine strain;Wine;Translocation;SSU1-R (XV-T-XVI);NA;Zymaflore VL1 (GN);Peltier at al. 2018;NA
SSU1;OC;Wine;SO2 production;QTL mapping, ISA;RHA;NA;BO213 (SB);Wine strain;Wine;Zymaflore VL1 (GN);Wine strain;Wine;Translocation;SSU1-R (XV-T-XVI);NA;BO213 (SB);Peltier at al. 2018;NA
SSU1;RTS;Wine;SO2 tolerance;Comparative gene expression;NA;Plasma membrane protein playing a major role in sulfite detoxification;Y9-16B;Wine strain;Wine;NA;NA;NA;Translocation;SSU1-R (VIII-T-XVI);S288c;Y9-16B;Perez-Ortin et al. - 2002;NA
UBP7;RTS;Bioethanol;Lignocellulosic hydrolysate tolerance, HWSSL ;ALE, Genome shuffling;Allele swapping;NA;CENPK;Laboratory strain;Laboratory;R57;Evolved strain;NA;nsSNP;p.Asn822Lys;NA;R57;Pinel et al. - 2015;NA
PBS2;RTS;Laboratory;NA;Mutagenesis;Site-directed mutagenesis;NA;W303;Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Lys389Met;S288c;NA;Reiser et al. - 2000;NA
GAA1;RTS;Wine;Low temperature adaptation;ALE;Deletion Mutant analysis;GPI-protein transamidase complex;Lalvin ICVGRE (P5);Industrial wine starter;Wine;NA;NA;NA;nsSNP;p.Thr108Ile;P5;NA;Rios-Garcia et al. 2015;NA
FPK1;RTS;Wine;Low temperature adaptation;QTL mapping, BSA;RHA;_oligopeptide transporter;P24;Industrial wine starter;Wine;Lalvin¨ICVGRE (P5);Industrial wine starter;Wine;nsSNP;p.R520Lys;NA;NA;Rios-Garcia et al. 2017;NA
OPT2;RTS;Wine;Low temperature adaptation;QTL mapping, BSA;indirect RHA;_oligopeptide transporter;P24;Industrial wine starter;Wine;Lalvin¨ICVGRE (P5);Industrial wine starter;Wine;NA;NA;NA;NA;Rios-Garcia et al. 2017;NA
PET494;RTS;Wine;Low temperature adaptation;QTL mapping, BSA;indirect RHA;_oligopeptide transporter;P24;Industrial wine starter;Wine;Lalvin¨ICVGRE (P5);Industrial wine starter;Wine;NA;NA;NA;NA;Rios-Garcia et al. 2017;NA
QCR2;RTS;Wine;Low temperature adaptation;QTL mapping, BSA;indirect RHA;_oligopeptide transporter;P24;Industrial wine starter;Wine;Lalvin¨ICVGRE (P5);Industrial wine starter;Wine;NA;NA;NA;NA;Rios-Garcia et al. 2017;NA
IRC7;OC;Wine;Volatile thiols production;QTL mapping, BSA;Deletion Mutant analysis;Beta-lyase involved in the production of thiols;YJM440 (YMJ450);Clinical isolate strain;Clinical;S288c (BY4741);Laboratory strain;Laboratory;nsSNP;p.*341Tyr;S288c;YJM450;Roncoroni et al. - 2011 ;NA
ALD6;MET;Wine;Acetic acid production;QTL mapping, ISA;RHA;Aldehyde dehydrogenase;DBVPG6044 (WA);West African palm wine strain;Palm wine;YPS128 (NA);Soil beneath strain;Nature;SNP or INDEL (5'/3'UTR);c.-82G, c.-50A;S288c;YPS128;Salinas et al. - 2012 ;NA
FLX1;OC;Wine;Succinic adic production;QTL mapping, ISA;RHA;Transporter of flavin adenine dinucleotide across the mitochondrial membrane;DBVPG6765 (WE);Wine strain;Wine;Y12 (SA);Sake strain;Sake;nsSNP;p.239Val;S288c;Y12;Salinas et al. - 2012 ;NA
GAT1;MET;Wine;Glycerol-ethanol ratio;QTL mapping, ISA;RHA;Transcriptional activator of genes involved in nitrogen catabolite repression;DBVPG6765 (WE);Wine strain;Wine;Y12 (SA);Sake strain;Sake;nsSNP;p.Ala441Val;S288c;Y12;Salinas et al. - 2012 ;NA
HAP4;MET;Wine;Fermentation completion, Ethanol accumulation capacity;QTL mapping, ISA;RHA;subunit of a transcription factor required for expression of cytochromes and respiratory genes ;DBVPG6044 (WA);West African palm wine strain;Palm wine;YPS128 (NA);Soil beneath strain;Nature;nsSNP;p.345Tyr, p.363Met, p.369Pro, p.501Lys;S288c;YPS128;Salinas et al. - 2012 ;NA
MBR1;MET;Wine;Fermentation completion, Ethanol accumulation capacity;QTL mapping, ISA;RHA;involved in mitochondrial function;DBVPG6044 (WA);West African palm wine strain;Palm wine;YPS128 (NA);Soil beneath strain;Nature;NA;NA;S288c;YPS128;Salinas et al. - 2012 ;NA
MDH2;OC;Wine;Succinic adic production;QTL mapping, ISA;RHA;Cytosolic malate dehydrogenase involved in malate/oxalacetate interconvertion, glyoxylate cycle and gluconeogenesis pathway;DBVPG6765 (WE);Wine strain;Wine;Y12 (SA);Sake strain;Sake;nsSNP;p.Gly87Cys;S288c;DBVPG6765 (WE);Salinas et al. - 2012 ;NA
YFL040W;MET;Wine;Glycerol-ethanol ratio;QTL mapping, ISA;RHA;putative sugar transporter;DBVPG6765 (WE);Wine strain;Wine;Y12 (SA);Sake strain;Sake;nsSNP;p.Pro44Ser;S288c;Y12;Salinas et al. - 2012 ;NA
YJR030C;MET;Wine;Fermentation completion, Ethanol accumulation capacity;QTL mapping, ISA;RHA;unknow;DBVPG6765 (WE);Wine strain;Wine;Y12 (SA);Sake strain;Sake;nsSNP;p.Asp343Glu, p.Val541Ile;S288c;Y12;Salinas et al. - 2012 ;NA
ASN1;MET;Wine;Nitrogen assimilation;Allele Specific Expression;RHA;Asparagine synthetase;DBVPG6044 (WA);West African palm wine strain;Wine;YPS128 (NA);Soil beneath strain;Nature;SNP or INDEL (5'/3'UTR);c.-323G>C;YPS128 (NA);DBVPG6044 (WA);Salinas et al. - 2016;NA
LEU3;RTS;Bioethanol;Lignocellulosic hydrolysate tolerance;GWAS;RHA;NA;YPS128 (NA);Soil beneath strain;Nature;NA;NA;NA;nsSNP;NA;NC;YPS128;Sardi et al. - 2018;NA
MNE1;RTS;Bioethanol;Lignocellulosic hydrolysate tolerance;GWAS;RHA;NA;YPS128 (NA);Soil beneath strain;Nature;NA;NA;NA;NA;NA;NC;YPS128;Sardi et al. - 2018;NA
SAP190;RTS;Bioethanol;Lignocellulosic hydrolysate tolerance;GWAS;RHA;NA;YPS128 (NA);Soil beneath strain;Nature;NA;NA;NA;nsSNP;NA;NC;YPS128;Sardi et al. - 2018;NA
MPR1;RTS;Bakery;Freezing tolerance, Air-dry tolerance;Mutagenesis;Mutant analysis;N-acetyltransferase;3346;Industrial baker's starter;bakery;NA;NA;NA;nsSNP;p.Phe65Leu;NA;NA;Sasano et al. - 2012;NA
GAL80;MET;Laboratory;Glucose-galactose switch;ALE, QTL mapping, BSA;Allele swapping;Repressor of the galactose utilization pathway;W303;Laboratory strain;Laboratory;SK1;Laboratory strain;Laboratory;nsSNP;p.Ile158Asn, p.Ile361Met;W303;NA;Segr�è et al. - 2006;NA
GAL80;MET;Laboratory;Glucose-galactose switch;ALE, QTL mapping, BSA;Allele swapping;Repressor of the galactose utilization pathway;W303;Laboratory strain;Laboratory;SK1;Laboratory strain;Laboratory;nsSNP;p.His36Tyr, p.Gln392His;W303;NA;Segr�è et al. - 2006;NA
GAL80;MET;Laboratory;Glucose-galactose switch;ALE, QTL mapping, BSA;Allele swapping;Repressor of the galactose utilization pathway;W303;Laboratory strain;Laboratory;SK1;Laboratory strain;Laboratory;nsSNP;p.Thr222Lys;W303;NA;Segr�è et al. - 2006;NA
PRO1;RTS;Bakery;Freezing tolerance;Mutagenesis;Allele swapping;Catalyzes the first step in proline biosynthesis;S288c (INVDput1pro1);Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Asp154Asn, p.Ile150Thr;S288c;NA;Sekine et al. - 2007, Sasano et al. - 2012  ;NA
RSP5;RTS;Bioethanol;Growth rate, High temparature growth;Comparative genomics;Allele swapping;E3 ubiquitin ligase of NEDD4 family;C3723;Longong fruit isolate;Nature;NA;NA;NA;SNP or INDEL (5'/3'UTR);c.-888T>C, c.-862T>C, c.-795A>G,c.-267T>C, c.-7delA;S288c;C3723;Shahsavarani et al. - 2012 ;NA
END3;RTS;Clinical;Growth rate, High temparature growth;QTL mapping, ISA;Site-directed mutagenesis;NA;YJM145 (YJM421);Clinical isolate strain;Clinical;S288c (S96);Laboratory strain;Laboratory;nsSNP;p.258Ser;S288c;S288c;Sinha et al. - 2006;NA
MKT1;RTS;Clinical;Growth rate, High temparature growth;QTL mapping, ISA;Site-directed mutagenesis;Form a complex that may mediate posttranscriptional regulation of HO;YJM145 (YJM421);Clinical isolate strain;Clinical;S288c (S96);Laboratory strain;Laboratory;nsSNP;p.Asp30Gly;S288c;YJM145;Sinha et al. - 2006;NA
RHO2;RTS;Clinical;Growth rate, High temparature growth;QTL mapping, ISA;Allele swapping;NA;YJM145 (YJM421);Clinical isolate strain;Clinical;S288c (S96);Laboratory strain;Laboratory;SNP or INDEL (5'/3'UTR);c.*6A, c.*37G>C, c.*119T>C, c.*261G>A, c.341G>A;S288c;YJM145;Sinha et al. - 2006;NA
NCS2;RTS;Clinical;Growth rate, High temparature growth;QTL mapping, ISA;Allele swapping;Required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs;YJM145 (YJM421);Clinical isolate strain;Clinical;S288c;Laboratory strain;Laboratory;nsSNP;p.His71Leu;S288c;YJM421;Sinha et al. - 2008;NA
BMH1;MET;Laboratory;Growth rate, Growth in respiration and fermentation, diauxic shift;ALE;Comparative genomics;Controls proteome at post-transcriptional level;UWOP83-787.3;Opuntia stricta isolates;Nature;NA;NA;NA;nsSNP;p.Gly55Asp, p.Gly174Asp, p.Asn178Ser;S288c;NA;Spor et al. - 2014;NA
BMH1;MET;Laboratory;Growth rate, Growth in respiration and fermentation, diauxic shift;ALE;Comparative genomics;Controls proteome at post-transcriptional level;Y55 (YJM981);Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Glu214*, p.Tyr216*, p.Lys217*, p.Lys230*;S288c;NA;Spor et al. - 2014;NA
ABZ1;OC;Wine;Ethyl esters production;QTL mapping, ISA;RHA;Para-aminobenzoate (PABA) synthase;EC1118 (59A);Industrial wine starter;Wine;S288c;Laboratory strain;Laboratory;nsSNP;p.Thr313Arg, p.Asn475Asp, p.Lys559Arg, p.Gln650Glu, p.Asn777Thr;S288c;59A;Steyer et al. - 2012 ;NA
PDR8;OC;Wine;Terpenes production;QTL mapping, ISA;RHA;Transcription factor;EC1118 (59A);Industrial wine starter;Wine;S288c;Laboratory strain;Laboratory;nsSNP;p.9Thr, p.17Leu, p.79Ser, p.198Asp, p.263Arg, p.267Ser;S288c;S288c;Steyer et al. - 2012 ;NA
APJ1;RTS;Bioethanol;Ethanol tolerance;QTL mapping, BSA;RHA;Chaperone with a role in SUMO-mediated protein degradation;VR1 (VR1-5B);Bioethanol production strain;Bioethanol;S288c (BY4741);Laboratory strain;Laboratory;NA;NA;S288c;VR1-5B;Swinnen et al. - 2012 ;CA2839829 A1
MKT1;RTS;Bioethanol;Ethanol tolerance;QTL mapping, BSA;RHA;Form a complex that may mediate posttranscriptional regulation of HO;VR1 (VR1-5B);Bioethanol production strain;Bioethanol;S288c (BY4741);Laboratory strain;Laboratory;nsSNP;p.Asp30Gly, p.Lys453Arg, c.A89G;S288c;VR1-5B;Swinnen et al. - 2012 ;CA2839829 A1
SWS2;RTS;Bioethanol;Ethanol tolerance;QTL mapping, BSA;RHA;Putative mitochondrial ribosomal protein of the small subunit;VR1 (VR1-5B);Bioethanol production strain;Bioethanol;S288c (BY4741);Laboratory strain;Laboratory;sSNP;c.21T;S288c;BY4741;Swinnen et al. - 2012 ;CA2839829 A1
GUT1;MET;Bioethanol;Growth rate, Growth on glycerol;QTL mapping, ISA;RHA;glycerol kinase;K7 (CBS4C);Sake strain;Sake;CENPK (CEN.PK113-1);Laboratory strain;Laboratory;nsSNP;p.Lys28Glu, p.Gly107Ser, p.Ile193Thr, p.Glu670Gln;S288c;CBS 6412-13A;Swinnen et al. - 2013;NA
HAA1;RTS;Bioethanol;Acetic acid tolerance;Mutagenesis, gTEM;Mutant analysis;NA;CENPK;Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Ser135Phe;NA;NA;Swinnen et al. - 2017;NA
END3;OC;Laboratory;Rough colony;QTL mapping, BSA;RHA;EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis;322134S;Clinical isolate strain;Clinical;S288c (BY4716);Laboratory strain;Laboratory;nsSNP;p.258Ser, p.268Asp;S288c;BY4716;Taylor et Ehrenreich - 2014;NA
FLO8;OC;Laboratory;Rough colony;QTL mapping, BSA;RHA;Transcription factor, required for flocculation, diploid filamentous growth, and haploid invasive growth;322134S;Clinical isolate strain;Clinical;S288c (BY4716);Laboratory strain;Laboratory;nsSNP;p.*142Trp, p.Cys383Gly;S288c;322134S;Taylor et Ehrenreich - 2014;NA
IRA2;OC;Laboratory;Rough colony;QTL mapping, BSA;Allele swapping;GTPase-activating protein that negatively regulates RAS;322134S;Clinical isolate strain;Clinical;S288c (BY4716);Laboratory strain;Laboratory;nsSNP;p.Leu2933*;322134S;322134S;Taylor et Ehrenreich - 2014;NA
MSS11;OC;Laboratory;Rough colony;QTL mapping, BSA;RHA;Transcription factor involved in regulation of invasive growth and starch degradation;322134S;Clinical isolate strain;Clinical;S288c (BY4716);Laboratory strain;Laboratory;nsSNP;p.46Val, p.64Ile, p.93Gly, p.480Ser, p.496Tyr, p.528Thr, p.538Ser;S288c;BY4716;Taylor et Ehrenreich - 2014;NA
TRR1;OC;Laboratory;Rough colony;QTL mapping, BSA;RHA;Key regulatory enzyme that determines the redox state of the thioredoxin system;322134S;Clinical isolate strain;Clinical;S288c (BY4716);Laboratory strain;Laboratory;sSNP;c.C156T;S288c;322134S;Taylor et Ehrenreich - 2014;NA
FAS2;OC;Brewery;Phenyl ethanol production;QTL mapping, BSA;Allele swapping;NA;Ethanol Red (ER18);Bioethanol production strain;Bioethanol;WLP575 (BTC-1D) ;Industrial ale beer starter;Brewery;nsSNP;p.Ala57Thr, p.Ser565Asn, p.Ala1136Thr, p.Val1624Ile, p.Ser1800Ans;NA;NA;Trindade de Carvalho et al. -  2017;NA
TOR1;OC;Brewery;Phenyl ethanol production;QTL mapping, BSA;Allele swapping;NA;Ethanol Red (ER18);Bioethanol production strain;Bioethanol;WLP575 (BTC-1D) ;Industrial ale beer starter;Brewery;nsSNP;p.*216E;NA;NA;Trindade de Carvalho et al. -  2017;NA
FLO1;OC;Laboratory;Adhesion, Floculation;Genomic;Allelic construction;Lectin-like protein involved in flocculation;S288c (BY4741);Laboratory strain;Laboratory;NA;NA;NA;STR;NA;S288c;NA;Verstrepen et al. - 2005 ;NA
MAL11;MET;Brewery;Maltose uptake, maltotriose uptake;Comparative genomics;NA;High-affinity maltose transporter;DQ091764;Industrial ale beer starter;Beer;NA;NA;NA;nsSNP;p.*395Glu;DQ091765;DQ091764;Vidgren et al. - 2009 ;NA
IAI11;RTS;Bioethanol;Ethanol tolerance;ALE;Allele swapping;Poly(A)RNA binding protein involved in nuclear mRNA export;S288c (FY5);Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Arg160Leu;NA;S288c (FY5);Voordeckers et al. - 2015;NA
MEX67;RTS;Bioethanol;Ethanol tolerance;ALE;Allele swapping;Poly(A)RNA binding protein involved in nuclear mRNA export;S288c (FY5);Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Met152Ile;NA;NA;Voordeckers et al. - 2015;NA
PRT1;RTS;Bioethanol;Ethanol tolerance;ALE;Allele swapping;eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3);S288c (FY5);Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Lys462Glu;NA;NA;Voordeckers et al. - 2015;NA
VPS70;RTS;Bioethanol;Ethanol tolerance;ALE;Allele swapping;Protein of unknown function involved in vacuolar protein sorting;S288c (FY5);Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Pro199Tyr;NA;S288c (FY5);Voordeckers et al. - 2015;NA
MSN2;MET;Sake;Fermentation rate;Comparative gene expression;Complementation test;Stress-responsive transcriptional activator;K7;Sake strain;Sake;NA;NA;NA;nsSNP;p.Ala103Thr, p.Ser119Asn, p.Asn598Asp;S288c;K7;Watanabe et al. - 2011;NA
MSN4;MET;Sake;Fermentation rate;Comparative gene expression;Complementation test;Stress-responsive transcriptional activator;K7;Sake strain;Sake;NA;NA;NA;nsSNP;c.T2C, c.C1540T;S288c;K7;Watanabe et al. - 2011;NA
RIM15;MET;Sake;Fermentation rate;NA;Complementation test;Protein kinase involved in cell proliferation in response to nutrients;K7;Sake strain;Sake;NA;NA;NA;INDEL;c.5055insAfs;S288c;K7;Watanabe et al. - 2012;NA
ADR1;MET;Sake;Fermentation rate;Comparative gene expression;Deletion mutant analysis;Carbon source-responsive zinc-finger transcription factor;K7;Sake strain;Sake;NA;NA;NA;nsSNP;p.Lys220*;S288c;K7;Watanabe et al. - 2013;NA
ADR1;MET;Sake;Fermentation rate;Comparative gene expression;Deletion mutant analysis;Carbon source-responsive zinc-finger transcription factor;K7;Sake strain;Sake;NA;NA;NA;nsSNP;p.Cys109Ser;S288c;K7;Watanabe et al. - 2013;NA
MKT1;MET;Laboratory;Growth rate, Growth on ethanol;ALE, QTL mapping, BSA, ISA;Allele swapping;Form a complex that may mediate posttranscriptional regulation of HO;SK1;Laboratory strain;Laboratory;S288c (S96);Laboratory strain;Laboratory;nsSNP;p.Asp30Gly;S288c;SK1;Wilkening et al. - 2014;NA
MKT1;RTS;Laboratory;5-fluorouracil tolerance;QTL mapping, BSA;Allele swapping;Form a complex that may mediate posttranscriptional regulation of HO;SK1;Laboratory strain;Laboratory;S288c (S96);Laboratory strain;Laboratory;nsSNP;p.Asp30Gly;S288c;SK1;Wilkening et al. - 2014;NA
MKT1;RTS;Laboratory;Growth rate, High temparature growth;QTL mapping, BSA;Allele swapping;Form a complex that may mediate posttranscriptional regulation of HO;SK1;Laboratory strain;Laboratory;S288c (S96);Laboratory strain;Laboratory;nsSNP;p.Asp30Gly;S288c;SK1;Wilkening et al. - 2014;NA
SFL1;OC;Laboratory;Adhesion, Floculation;QTL mapping, ISA;Allele swapping;Involved in repression of flocculation-related genes;SK1;Laboratory strain;Laboratory;S288c (S96);Laboratory strain;Laboratory;nsSNP;p.Gln477*;S288c;SK1;Wilkening et al. - 2014;NA
TAO3;MET;Laboratory;Growth rate, Growth on ethanol;ALE, QTL mapping, BSA, ISA;Allele swapping;Component of the RAM signaling network;SK1;Laboratory strain;Laboratory;S288c (S96);Laboratory strain;Laboratory;nsSNP;p.Glu1493Gln;S288c;SK1;Wilkening et al. - 2014;NA
TAO3;MET;Laboratory;Growth rate, Growth on ethanol;ALE, QTL mapping, BSA, ISA;Allele swapping;Component of the RAM signaling network;SK1;Laboratory strain;Laboratory;S288c (S96);Laboratory strain;Laboratory;nsSNP;p.Glu1493Gln;S288c;SK1;Wilkening et al. - 2014;NA
TAO3;RTS;Laboratory;Growth rate, High temparature growth;QTL mapping, BSA, ISA;Allele swapping;Component of the RAM signaling network;SK1;Laboratory strain;Laboratory;S288c (S96);Laboratory strain;Laboratory;nsSNP;p.27Gly, p.128Arg, p.176tyr, p.399Thr, p.495Thr, p.536Ser, p.1660Thr, p.1739Ile, p.2065Val;S288c;S96;Wilkening et al. - 2014;NA
AQY1;RTS;Laboratory;Freezing tolerance, Osmolarity tolerance, Sporulation efficiency;Comparative gene expression;Complementation test;Spore-specific water channel;YPS163;Bark oak tree strain;Nature;S288c;Laboratory strain;Laboratory;INDEL;c.A881delfs;YPS163;SK1;Will et al. - 2010;NA
AQY1;RTS;Laboratory;Freezing tolerance, Osmolarity tolerance, Sporulation efficiency;Comparative gene expression;Complementation test;Spore-specific water channel;YPS163;Bark oak tree strain;Nature;S288c;Laboratory strain;Laboratory;INDEL;c.1_106delfs;YPS163;NCYC3462;Will et al. - 2010;NA
AQY1;RTS;Laboratory;Freezing tolerance, Osmolarity tolerance, Sporulation efficiency;Comparative genomics;Complementation test;Spore-specific water channel;YPS163;Bark oak tree strain;Nature;S288c;Laboratory strain;Laboratory;nsSNP;p.Val121Met;YPS163;S288c;Will et al. - 2010;NA
AQY2;RTS;Laboratory;Freezing tolerance, Osmolarity tolerance, Sporulation efficiency;Comparative gene expression;Complementation test;Water channel that mediates water transport across cell membranes;YPS163;Bark oak tree strain;Nature;S288c;Laboratory strain;Laboratory;INDEL;c.528delfs;YPS163;NCYC3462;Will et al. - 2010;NA
AQY2;RTS;Laboratory;Freezing tolerance, Osmolarity tolerance, Sporulation efficiency;Comparative gene expression;Complementation test;Water channel that mediates water transport across cell membranes;YPS163;Bark oak tree strain;Nature;S288c;Laboratory strain;Laboratory;INDEL;c.324_334delfs;YPS163;S288c;Will et al. - 2010;NA
AQY2;RTS;Laboratory;Freezing tolerance, Osmolarity tolerance, Sporulation efficiency;Comparative gene expression;Complementation test;Water channel that mediates water transport across cell membranes;YPS163;Bark oak tree strain;Nature;S288c;Laboratory strain;Laboratory;INDEL;c.25delfs;YPS163;SK1;Will et al. - 2010;NA
SPT15;RTS;Laboratory;Ethanol tolerance,  Osmolarity tolerance;Mutagenesis, gTEM;Mutant analysis;TATA-binding protein;S288c (BY4741);Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Leu76Val, p.Leu175Ser;S288c;NA;Yang et al. - 2011 ;NA
SPT15;RTS;Laboratory;Ethanol tolerance,  Osmolarity tolerance;Mutagenesis, gTEM;Mutant analysis;TATA-binding protein;L3264;Laboratory strain;Laboratory;NA;NA;NA;nsSNP;p.Ser42Asn, p.Cys78Arg, p.Ser163Pro, p.Ile212Asn;S288c;NA;Yang et al. - 2011 ;NA
MKT1;RTS;Laboratory;Growth rate, High temparature growth;QTL mapping, BSA;RHA;Form a complex that may mediate posttranscriptional regulation of HO;MUCL2817 (21A);Orange juice isolate;Nature;S288c (BY4742);Laboratory strain;Laboratory;nsSNP;p.Asp30Gly;S288c;21A;Yang et al. - 2013;NA
NCS2;RTS;Laboratory;Growth rate, High temparature growth;QTL mapping, BSA;RHA;Required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs;MUCL2817 (21A);Orange juice isolate;Nature;S288c (BY4742);Laboratory strain;Laboratory;nsSNP;p.His71Leu;S288c;21A;Yang et al. - 2013;NA
PRP42;RTS;Laboratory;Growth rate, High temparature growth;QTL mapping, BSA;RHA;U1 snRNP protein involved in splicing;MUCL2817 (21A);Orange juice isolate;Nature;S288c (BY4742);Laboratory strain;Laboratory;nsSNP;p.296His, p.467Phe, p.526Glu;S288c;BY4742;Yang et al. - 2013;NA
SMD2;RTS;Laboratory;Growth rate, High temparature growth;QTL mapping, BSA;RHA;part of the spliceosome;MUCL2817 (21A);Orange juice isolate;Nature;S288c (BY4742);Laboratory strain;Laboratory;nsSNP;NA;S288c;21A;Yang et al. - 2013;NA
AMN1;OC;Laboratory;Clumpiness;QTL mapping, ISA;Deletion mutant analysis;Negative regulator of the mitotic exit network in daughter cells;RM11 (YEF1946);Wine strain;Wine;S288c (BY4716);Laboratory strain;Laboratory;nsSNP;p.Val368Asp;S288c;RM11-1a;Yvert et al. - 2003 ;NA
GPA1;OC;Laboratory;Cell morphology;QTL mapping, ISA;Allele swapping;Subunit of the G protein involved in pheromone response;RM11 (YEF1946);Wine strain;Wine;S288c (BY4716);Laboratory strain;Laboratory;nsSNP;p.469Ile;S288c;BY4716;Yvert et al. - 2003 ;NA
SSU1;RTS;Wine;SO2 tolerance;QTL mapping, ISA;NA;Plasma membrane protein playing a major role in sulfite detoxification;BO213 (SB);Industrial wine starter;Wine;Zymaflore VL1 (GN);Industrial wine starter;Wine;Translocation;SSU1 (XV-T-XVI);S288c;GN;Zimmer et al. - 2014;NA