Figure 1A, left Time (days) control control control control control control control control celecoxib celecoxib celecoxib celecoxib celecoxib celecoxib celecoxib celecoxib wk4 4 6,668908 6,646631 6,382118 6,765818 6,668908 6,646631 6,382118 6,765818 wk6 6 4,206286 4,907841 4,796852 4,681241 4,783332 4,708591 5,754409 5,746073 6,066043 4,597695 4,5325 4,363988 wk12 12 4,394452 5,14289 4,800167 4,193125 4,825815 4,893429 4,276002 4,087781 5,098505 5,668908 4,915505 5,117404 5,354262 5,361123 4,822691 5,338775 Figure 1A, right Time (days) control control control control control control control control celecoxib celecoxib celecoxib celecoxib celecoxib celecoxib celecoxib celecoxib wk4 4 4,901218 4,37716 4,250908 5,418434 4,901218 4,37716 4,250908 5,418434 wk6 6 4,170144 3,912328 4,119784 4,35357 3,890756 3,708591 4,707366 4,621135 4,554562 4,491306 4,510545 4,210479 wk12 12 4,752847 5,494155 5,267829 4,893229 5,274527 4,843432 3,957128 4,549739 5,340206 5,515026 5,31471 5,390511 5,420022 5,143639 5,194592 5,220317 Figure 1B, left control celecoxib 24 25 24 26 28 26 25 24 25 26 28 25 26 28 26 22 25 24 30 28 27 29 25 26 27 29 25 29 25 28 24 28 Figure 1B, Right control celecoxib 30 29 33 28 28 27 28 27 30 29 28 30 29 31 27 23 Figure 1D.1 control celecoxib 1069,6 824,74 763,72 616,98 711,75 906,54 697,45 486,2 738,61 305,35 566,43 320,11 Figure 1D.2 control celecoxib 607,6 528,82 431,88 484,12 519,03 864,78 506,9 338,3 535,9 297,6 388,68 249,9 Figure 1D.3 control celecoxib 565,6 506,9 375,76 249,34 278,13 276,66 203,5 243,1 538,23 199,95 270,18 135,66 Figure 1D.4 control celecoxib 226,8 328,8 170,8 172,9 153,3 214,02 122,1 134,3 165,43 106,95 161,16 89,25 Figure 2A, left control Ibuprofen 8,099063 6,036884 8,723521 7,362634 8,983933 7,131306 8,185443 8,167218 8,229711 6,936079 8,844564 8,169281 6,391359 7,567221 8,113343 7,470825 7,975333 7,6452 7,652026 7,702331 8,227016 6,223195 8,425068 8,215142 8,401301 8,046396 Figure 2A, right control Ibuprofen 5,005395 4,607455 4,788875 3,875061 4,80956 4,380211 4,924279 4,431364 4,883661 4,477121 5,011782 4,547159 4,964966 4,337459 4,892095 4,687975 4,819544 4,80956 4,772688 4,857332 4,674402 5,002166 4,819544 4,939519 4,834103 4,799341 Figure 2B control Ibuprofen 26,8 17,7 32,6 20 29,5 26,6 26,1 12,1 Figure 2C control Ibuprofen 431,5476559 41,45959374 877,0187504 324,7339574 1175,974536 255,0871448 402,812397 197,3182043 Figure 2D, left control Ibuprofen 4,52943 5,138366 4,342423 4,331225 4,268578 5,14289 4,188647 5,811575 4,987666 5,273973 4,649724 5,245611 5,358392 5,251784 4,556303 5,70181 Figure 2D, right control Ibuprofen 4,402777 4,554368 4,415419 4,354365 4,387864 4,484395 4,556945 5,03535 4,432862 4,899602 4,385964 4,645029 4,81478 4,985157 4,364488 5,073352 Figure 2E control Ibuprofen 26,6 57,5 51,5 63,4 39,3 47,6 69,8 68,8 66 59,7 60,1 58,8 41,6 43,1 32 60,6 Figure 2F alive dead control 16 16 Ibuprofen 5 27 Figure 3B, left control celecoxib 4,30294 4,67786 4,63112 4,34939 4,32679 4,58243 4,66436 4,25484 4,5617 4,33662 4,63112 4,77121 4,20952 5,08021 4,97219 4,50177 4,81266 4,54195 4,39421 4,76035 Figure 3B, right control celecoxib 4,0202 4,52549 4,64248 4,27021 4,30989 4,31672 3,84298 4,75974 3,92552 4,38849 3,76582 4,87556 3,97294 3,91495 3,8362 4,61092 4,05046 4,69807 3,91137 4,6749 3,92552 4,65042 4,13723 4,34624 4,15891 4,46237 4,48136 4,55194 3,69618 4,62616 3,82582 4,49282 Figure 3C control control control control control control celecoxib celecoxib celecoxib celecoxib celecoxib celecoxib 0 0,028 0,096 0,034 0,061 0,074 0,035 0,018 0,046 0,026 0,057 0,031 0,033 3 0,45 0,46 0,6 1,06 0,46 0,52 0,38 0,2 0,5 0,6 0,41 0,56 6 0,35 0,21 0,3 0,15 0,1 0,13 0,31 0,2 0,28 0,45 0,31 0,26 Figure 3E, left Time (days) control control control control control control control control celecoxib celecoxib celecoxib celecoxib celecoxib celecoxib celecoxib celecoxib wk0 0 694656 990080 694656 990080 wk6 6 3470000 2860000 3310000 2910000 2630000 2510000 3020000 1820000 2170000 1900000 2290000 1550000 wk12 12 1920960 2090400 2046240 2271680 2224880 2843760 1636800 1102080 2602800 2311680 1607112 2069760 1389440 1439360 1100864 1988800 Figure 3E, right Time (days) control control control control control control control control celecoxib celecoxib celecoxib celecoxib celecoxib celecoxib celecoxib celecoxib wk0 0 0 0 0 0 wk6 6 6,3 7,3 6,82 7,55 7,93 6,52 6,84 7,61 11,1 5,1 4,7 7,71 wk12 12 2,36 5,03 5,35 3,65 4,88 4,37 2,34 3,19 3,79 3,81 3,8 4,34 5,72 4,22 4,98 3,38 Figure 3F control celecoxib 45199,95 108999,9 102999,9 89600 103999,9 68500,07 84699,92 99299,94 110000,1 85200,08 134000,1 67500,04 35300,02 55100,05 34399,96 72299,95 Figure 3H, left control celecoxib 94,9 77,8 93,5 68,5 89,1 67,4 83,5 61,9 81,5 58,9 79,5 58,2 Figure 3H, right control celecoxib 1,611 0,951 1,415 0,82 1,224 0,774 1,058 0,732 1 0,698 0,985 0,709 Figure 4C control celecoxib 30,5 9,39 Figure 4D control celecoxib 15,229 7,483 Figure 4E +control cells +celecoxib cells 7,62 10,1 8,27 5,45 9,12 8,31 7,64 9,85 10,9 6,46 8,81 5,92 8,25 7,65 8,74 6,88 Figure 4F, left +control cells +celecoxib cells 90,6 64,7 87 55,8 84 56,8 71,6 57,2 68,1 53,5 73,8 46,8 68,3 53,5 64,8 50,9 Figure 4F, right +control cells +celecoxib cells 31,782 28,791 35,593 22,098 37,138 30,901 32,573 32,84 35,042 28,954 30,568 25,661 29,745 26,402 35,123 22,036 Figure 4G, left no transfer +control cells +celecoxib cells 6,03 4,73 4,7 5,56 5,17 3,98 6,38 3,99 4,4 5,95 4,96 4,69 4,84 5,02 4,7 4,97 4,14 4,6 4,53 4,92 Figure 4G, right no transfer +control cells +celecoxib cells - 4,17 4,23 4,37 4,58 4,38 4,2 3,38 4,58 4,42 4,17 4 4,49 4,13 4,41 3,87 4,6