,,centrality of nodes of PPI network,,,,,,, Rank,Degree centrality,,,Betweenness centrality,,Closeness centrality,,Eigenvector centrality, ,Gene symbol,Expression in HCC,,Gene symbol,Expression in HCC,Gene symbol,Expression in HCC,Gene symbol,Expression in HCC 1,TOP2A,up-regulated,,TOP2A,up-regulated,TOP2A,up-regulated,CCNB1,up-regulated 2,NDC80,up-regulated,,ESR1,down-regulated,NDC80,up-regulated,CDK1,up-regulated 3,CCNB1,up-regulated,,CYP3A4,down-regulated,ESR1,down-regulated,NDC80,up-regulated 4,CDK1,up-regulated,,CYP2E1,down-regulated,CDKN3,up-regulated,ZWINT,up-regulated 5,CDKN3,up-regulated,,NDC80,up-regulated,BIRC5,up-regulated,BUB1,up-regulated 6,ZWINT,up-regulated,,IGF1,down-regulated,CENPF,up-regulated,TTK,up-regulated 7,TTK,up-regulated,,CYP2B6,down-regulated,CCNB1,up-regulated,NCAPG,up-regulated 8,BUB1,up-regulated,,COL1A2,up-regulated,CDK1,up-regulated,RACGAP1,up-regulated 9,CENPF,up-regulated,,CENPF,up-regulated,EZH2,up-regulated,BUB1B,up-regulated 10,NCAPG,up-regulated,,ENO3,down-regulated,NEK2,up-regulated,MAD2L1,up-regulated 11,RACGAP1,,,BIRC5,,CYP3A4,,TOP2A, 12,BIRC5,,,HGF,,BUB1,,CENPF, 13,BUB1B,,,SPP1,,IGF1,,ASPM, 14,MAD2L1,,,SLC22A1,,CDC20,,DLGAP5, 15,DTL,,,FOS,,FOS,,PBK, 16,ASPM,,,CDKN3,,TTK,,HMMR, 17,DLGAP5,,,DCN,,ZWINT,,CCNB2, 18,NUSAP1,,,CXCL12,,NCAPG,,DTL, 19,PBK,,,ITGA2,,RACGAP1,,CDKN3, 20,HMMR,,,TTK,,BUB1B,,NUSAP1, 21,CCNB2,,,CCNB1,,MAD2L1,,KIF20A, 22,CDC20,,,EZH2,,DTL,,ANLN, 23,ANLN,,,CYP1A2,,ASPM,,RRM2, 24,MLF1IP,,,CDC20,,DLGAP5,,NUF2, 25,RRM2,,,GPC3,,NUSAP1,,MLF1IP, 26,KIF20A,,,EGR1,,PBK,,CDC20, 27,NEK2,,,CDK1,,HMMR,,NEK2, 28,NUF2,,,CYP26A1,,CCNB2,,PRC1, 29,PRC1,,,CAP2,,ANLN,,BIRC5, 30,RAD51AP1,,,NUSAP1,,MLF1IP,,KIF14, 31,EZH2,,,C9,,RRM2,,RAD51AP1, 32,KIF4A,,,HAO2,,KIF20A,,KIF4A, 33,KIF14,,,RSPO3,,NUF2,,HELLS, 34,HELLS,,,SERPINE1,,PRC1,,EZH2, 35,UBE2T,,,IGF2BP3,,RAD51AP1,,ECT2, 36,ECT2,,,NEK2,,KIF4A,,UBE2T, 37,CENPK,,,LPA,,KIF14,,CENPK, 38,FAM83D,,,KMO,,HELLS,,FAM83D, 39,E2F8,,,IGFALS,,SPP1,,E2F8, 40,SGOL2,,,ADH4,,UBE2T,,SGOL2, 41,ESR1,,,BUB1,,ECT2,,GINS1, 42,GINS1,,,ACSL4,,CENPK,,ESR1, 43,CYP3A4,,,ALDOB,,EGR1,,CENPW, 44,CYP2B6,,,APOF,,FAM83D,,FOS, 45,CYP2E1,,,ZWINT,,SLC22A1,,EGR1, 46,IGF1,,,MLF1IP,,E2F8,,SPP1, 47,SPP1,,,CENPK,,CYP2B6,,IGF1, 48,HGF,,,CYP2A6,,SGOL2,,CYP3A4, 49,FOS,,,GHR,,ITGA2,,UHRF1BP1, 50,CYP1A2,,,LCAT,,GINS1,,SLC22A1, 51,EGR1,,,NCAPG,,CYP1A2,,ENO3, 52,CYP26A1,,,RACGAP1,,HGF,,GYS2, 53,DCN,,,BUB1B,,SERPINE1,,SPINK1, 54,ITGA2,,,MAD2L1,,CXCL12,,IGF2BP3, 55,CYP2A6,,,NUF2,,CYP2E1,,RSPO3, 56,KMO,,,DTL,,COL1A2,,CNDP1, 57,SERPINE1,,,RRM2,,ENO3,,S100P, 58,ACSL4,,,ASPM,,CYP2A6,,PRR11, 59,CYP4A11,,,DLGAP5,,CENPW,,HGF, 60,CXCL12,,,PBK,,UHRF1BP1,,SERPINE1, 61,COL1A2,,,HMMR,,DCN,,ITGA2, 62,SLC22A1,,,CCNB2,,GYS2,,CYP2B6, 63,CENPW,,,PRC1,,RSPO3,,CXCL12, 64,NAT2,,,HELLS,,GHR,,CYP1A2, 65,LPA,,,ANLN,,CNDP1,,GHR, 66,GPC3,,,KIF20A,,SPINK1,,COL1A2, 67,ENO3,,,KIF4A,,KMO,,DCN, 68,APOF,,,RAD51AP1,,CYP26A1,,FOSB, 69,CYP39A1,,,KIF14,,ACSL4,,CYP2A6, 70,CAP2,,,CYP4A11,,CYP4A11,,CYP2E1, 71,C9,,,ADH1B,,NAT2,,HAMP, 72,PDGFRA,,,UBE2T,,IGF2BP3,,CYP4A11, 73,GHR,,,CYP39A1,,PDGFRA,,KMO, 74,ADH4,,,ECT2,,HAMP,,ACSL4, 75,IGFALS,,,SGOL2,,SLCO1B3,,CYP26A1, 76,IGF2BP3,,,FAM83D,,IGFALS,,DPT, 77,GYS2,,,SULT1C2,,FOSB,,SLCO1B3, 78,BCHE,,,FREM2,,SULT1C2,,NAT2, 79,HAO2,,,HOXA13,,PRR11,,PDGFRA, 80,RSPO3,,,ZIC2,,GPC3,,IGFALS, 81,HAMP,,,GYS2,,DPT,,SULT1C2, 82,UHRF1BP1,,,CNDP1,,S100P,,GPC3, 83,SLCO1B3,,,HHIP,,LPA,,LPA, 84,DPT,,,BCHE,,BCHE,,BCHE, 85,LCAT,,,GLYAT,,ALDOB,,ALDOB, 86,IDO2,,,TFE3,,APOF,,HAO2, 87,ALDOB,,,PRR11,,LCAT,,FREM2, 88,ADH1B,,,CTHRC1,,IDO2,,HGFAC, 89,FCN3,,,SPINK1,,HGFAC,,CXCL14, 90,FOSB,,,HAMP,,ADH4,,CCL20, 91,FCN2,,,HGFAC,,C9,,IDO2, 92,MBL2,,,MT1F,,ADH1B,,CAP2, 93,SULT1C2,,,MT1M,,CXCL14,,CYP39A1, 94,FREM2,,,S100P,,CCL20,,ADH4, 95,HOXA13,,,UHRF1BP1,,AKR1B10,,TFE3, 96,ZIC2,,,SLCO1B3,,TFE3,,CTHRC1, 97,CNDP1,,,GINS1,,CTHRC1,,COL15A1, 98,HHIP,,,CXCL14,,COL15A1,,ADH1B, 99,GLYAT,,,E2F8,,HAO2,,APOF, 100,TFE3,,,DPT,,CAP2,,LCAT, 101,PRR11,,,ROBO1,,CYP39A1,,C9, 102,CTHRC1,,,IDO2,,FREM2,,AKR1B10, 103,SPINK1,,,AKR1B10,,HHIP,,HHIP, 104,HGFAC,,,C7,,C7,,GLYAT, 105,MT1F,,,PDGFRA,,GLYAT,,ROBO1, 106,MT1M,,,COL15A1,,ROBO1,,C7, 107,S100P,,,CENPW,,FCN3,,HOXA13, 108,CXCL14,,,CCL20,,FCN2,,ZIC2, 109,ROBO1,,,FCN3,,MBL2,,MT1F, 110,AKR1B10,,,NAT2,,HOXA13,,MT1M, 111,C7,,,FOSB,,ZIC2,,FCN3, 112,COL15A1,,,FCN2,,MT1F,,FCN2, 113,CCL20,,,MBL2,,MT1M,,MBL2,