This PDF file includes:

• Fig. S1. In vitro results at RF saturation field strength of 3 μΤ.
• Fig. S2. In vitro pH measurement variation as a function of ΔΒ₀ shift at 4-μΤ RF saturation power.
• Fig. S3. In vitro pH measurement variation with ΔΒ₀ shift at 3-μΤ RF saturation power.
• Fig. S4. Biochemical and clinical measures in the RD and HP Mut^−/−;Tg^INS-Alb-Mut mice as compared to heterozygote littermates.
• Fig. S5. In vivo Z-spectra.
• Fig. S6. Representative ΔB₀ maps for RD and HP diet mice.
• Fig. S7. pH-histogram plots depicting the percentage of pixels across the detectable pH range and normal distribution analysis for all control (Mut^+/−) mice imaged in this study.
• Fig. S8. pH-histogram plots depicting the percentage of pixels across the detectable pH range and normal distribution analysis for all Mut^−/− mice imaged in this study.
• Fig. S9. MRI metrics versus weight correlation plots for HP and RD Mut^−/− mice.
• Fig. S10. pH images calculated for a healthy control mouse using our 72, 38, and 2-offset protocols.

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