This PDF file includes:

• Table S1. Used expression constructs, materials, and cell lines.
• Fig. S1. BRAF KinCon reporter activities and BRAF profiling.
• Fig. S2. Impact of defined kinase mutations on BRAF KinCon reporter dynamics.
• Fig. S3. BRAF KinCon reporter dynamics.
• Fig. S4. Complex formation of RAS:BRAF and PPI reporter dynamics.
• Fig. S5. Impact of vemurafenib on indicated PPIs.
• Fig. S6. Impact of BRAFi on binary RAS:RAF interactions.
• Fig. S7. PPI reporter dynamics and NS1 monobody IPs.
• Fig. S8. Validation of PPI dynamics and impact of RAFi on RAF conformations.

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