{"text_format":"2","workbook":"xlsx","n_sheets":1,"sheets":["S14_Summary_statistics"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"S14_Summary_statistics","index":0,"n_rows":308,"n_cols":8,"rows_kept":308,"cut":false,"hidden":false,"merged":[]}
["Supplementary Data 14: Summary statistics "]
[]
["Dictionary"]
["var","Variable included in the model or level of categorical variable included in the cox regression (for categorical variables, reference level is indicated above each cox model summary)"]
["coef","Cox regression coefficient"]
["exp.coef","Exponential of the regression coefficient (hazard ratio)"]
["se.coef","Standard error"]
["z","Wald statistic"]
["P.z","Individual Wald test pvalue "]
["lower.95","Lower endpoint of 95% confidence interval "]
["upper.95","Upper endpoint of 95% confidence interval "]
[]
["stat","Value of the statistic associated with the test"]
["df","Degrees of freedom"]
["pvalue","P-value associated with each test"]
["test","Name of statistical test"]
[]
["Fig 1C upper panel and Supplementary Figure 10A lower panel"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["AC->TC",-2.894584020627,0.055322033133581,1.15767922674944,-2.50033338574665,0.0124076481498243,0.00572110328208615,0.534954046296651]
["TC->TC",-2.37446227522703,0.0930645188556415,0.656375390737005,-3.61753702033357,0.000297419800584974,0.025708479460294,0.336892918276584]
["PCA->UC",-0.933450605767547,0.39319460727601,0.629066582818464,-1.4838661459099,0.137844434708505,0.114589574479346,1.3491803237196]
["LCNEC->LCNEC",0.232144904109054,1.26130248349968,0.412560024844369,0.562693644874166,0.573643512478929,0.561885106935116,2.83133319471691]
["Reference is AC->AC"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[29.67,4,5.71448608658274E-006,"Wald test"]
[53.0801267287362,4,8.19901850567568E-011,"Likelihood ratio test"]
[48.1487469755929,4,8.78744317152255E-010,"Score (logrank) test"]
[]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["TC->TC",0.520121745399979,1.68223244129384,1.14620976509251,0.453775357042086,0.649990522130155,0.177922340554857,15.9052875412737]
["PCA->UC",1.96113341485946,7.10737810966933,1.20023979369899,1.63395133635379,0.10226906912574,0.676181766584511,74.7059830509246]
["AC->AC",2.89458402062701,18.0759806420239,1.15767922674944,2.50033338574666,0.0124076481498241,1.86931944327321,174.791460788902]
["LCNEC->LCNEC",3.12672892473606,22.7992792754768,1.10118955083104,2.83941027444041,0.00451970039309365,2.63382474377546,197.358285402114]
["Reference is AC->TC"]
[]
["Global statistics"]
["test","df","pvalue","stat"]
[29.67,4,5.71449E-006,"Wald test"]
[53.08012673,4,8.19902E-011,"Likelihood ratio test"]
[48.14874698,4,8.78744E-010,"Score (logrank) test"]
[]
[]
["Fig 1C lower panel"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["Typical",-1.74572106960538,0.174519103165203,0.578779359265815,-3.01621169044424,0.00255954497700815,0.0561287135862295,0.542626321246367]
["LCNEC",0.886495960568412,2.42661179314153,0.337818524913217,2.62417805771944,0.00868583639092,1.25155129570398,4.70491686183858]
["Reference is Atypical"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[28.6,2,6.16193317311726E-007,"Wald test"]
[47.4776574712241,2,4.9018235420416E-011,"Likelihood ratio test"]
[43.6485021659337,2,3.32543285295105E-010,"Score (logrank) test"]
[]
[]
["Fig 2A"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["Ca A",-1.90229279192704,0.149226082332908,0.61671134170766,-3.08457565683749,0.00203842757707591,0.0445552712243101,0.499793246377498]
["Ca B",-0.951127028766012,0.386305400721857,0.651041120147775,-1.46093234256866,0.144034009709905,0.107835951234839,1.38387857591098]
["LCNEC",0.295049224044696,1.34319247442542,0.524569056342341,0.562460214679806,0.573802503117531,0.480423518550875,3.75536574228313]
["Reference is Supra-ca"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[34.73,3,1.3882835383107E-007,"Wald test"]
[47.2425237724946,3,3.08631486649432E-010,"Likelihood ratio test"]
[47.6659125320055,3,2.50820499403092E-010,"Score (logrank) test"]
[]
[]
["Supplementary Figure 4"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["LF1",0.798125220855148,2.22137243949279,0.151345243481552,5.27354016878923,1.33816947678157E-007,1.65118629195096,2.98845474856006]
["LF2",0.396181549957744,1.4861391015521,0.161563140122404,2.45217782755143,0.0141994469689893,1.08277112788093,2.0397749554742]
["LF3",0.359125785497763,1.43207692475179,0.210935438697977,1.70253887973736,0.0886543965478831,0.947147846178065,2.16528425491557]
[]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[28.44,3,2.93747345233818E-006,"Wald test"]
[38.2240792404477,3,2.53396968331959E-008,"Likelihood ratio test"]
[35.6852223663855,3,8.72835052890829E-008,"Score (logrank) test"]
[]
[]
["Supplementary Figure 9 upper right panel"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["AC->TC",-1.77874644931485,0.168849676287121,1.12578487347989,-1.5800056398134,0.114105574909848,0.0185879035672674,1.5338046638283]
["TC->TC",-20.6057078614575,1.1247468358012E-009,10966.6669026977,-0.00187893988613703,0.998500823756294,0,{"$f":"#NUM!","v":{"$error":"#NUM!"}}]
["PCA->UC",-20.6054168258894,1.12507422477414E-009,9718.2682057819,-0.00212027661611872,0.99830826529092,0,{"$f":"#NUM!","v":{"$error":"#NUM!"}}]
["LCNEC->LCNEC",-0.254902506573041,0.774992050908972,0.581732222582949,-0.4381784207195,0.661256950241546,0.247814025456893,2.42364280175325]
["Reference is AC->AC"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[2.51,4,0.642697470588971,"Wald test"]
[19.8766821041843,4,0.000528183441679579,"Likelihood ratio test"]
[16.0137341272156,4,0.00300078976444065,"Score (logrank) test"]
[]
[]
["Supplementary Figure 9 lower right panel"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["Typical",-19.4783124213538,3.47277301849549E-009,7494.845018198,-0.00259889462344573,0.997926384439087,0,{"$f":"#NUM!","v":{"$error":"#NUM!"}}]
["LCNEC",0.638783507988873,1.89417522815346,0.543213553127115,1.17593440795354,0.239621087961907,0.653184601534652,5.49293382991649]
["Reference is Atypical"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[1.38,2,0.500867155629158,"Wald test"]
[12.7662441265085,2,0.0016898389283563,"Likelihood ratio test"]
[9.16941927852109,2,0.0102067129862599,"Score (logrank) test"]
[]
[]
["Supplementary Figure 10B lower panel"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["AC->TC",-1.98201057451449,0.137791917700411,0.828919291206275,-2.39107787156237,0.0167989894017279,0.0271422823855803,0.699521591951448]
["TC->TC",-2.47048565487775,0.0845437899257123,0.639018272216316,-3.86606418359421,0.000110605841133965,0.0241628619705634,0.295811498807991]
["PCA->UC",-1.88391968484745,0.151993171293235,1.13234877901002,-1.66372739545363,0.0961669189804072,0.0165183646215075,1.39856000573418]
["LCNEC->LCNEC",0.191307371826695,1.21083157040064,0.412106964479825,0.464217759746355,0.642491738379326,0.539880512891192,2.71562513717616]
["Reference is AC->AC"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[31.95,4,1.95486855385681E-006,"Wald test"]
[55.1257372708453,4,3.05773657947504E-011,"Likelihood ratio test"]
[51.3558956737778,4,1.88088120574273E-010,"Score (logrank) test"]
[]
[]
["Supplementary Figure 10C lower panel"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["AC->TC",-1.89294787666874,0.150627123536533,1.10347669622694,-1.71543983043883,0.0862646180929863,0.0173229605318857,1.30973746104935]
["TC->TC",-2.79147755113067,0.0613305279440106,0.839280494313183,-3.32603649202529,0.000880903949087009,0.0118380413123496,0.31774121737243]
["PCA->UC",-1.78231062984255,0.168248936766792,0.589658998729596,-3.02261244835148,0.00250602957147971,0.0529704519903405,0.534405572531607]
["LCNEC->LCNEC",-0.0437390175853462,0.957203738220354,0.47736997562912,-0.0916249865268612,0.926995998573573,0.375548754577216,2.43973381697005]
["Reference is AC->AC"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[32.74,4,1.35153367998721E-006,"Wald test"]
[49.002043366354,4,5.83309517410824E-010,"Likelihood ratio test"]
[47.9754860624017,4,9.54954323573473E-010,"Score (logrank) test"]
[]
[]
["Supplementary Figure 11A left panel"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["Typical",-1.30091956909186,0.272281296412717,0.614729228497718,-2.11624811182488,0.0343237112709313,0.0816129999007741,0.908398226585547]
["LCNEC",1.28280281954024,3.60673459811572,0.403163743138702,3.1818407318907,0.00146342270354689,1.63659260913908,7.9485477256848]
["Reference is Atypical"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[30.19,2,2.78656355040314E-007,"Wald test"]
[46.5780905852473,2,7.68592497092696E-011,"Likelihood ratio test"]
[44.7922762432728,2,1.87707142252213E-010,"Score (logrank) test"]
[]
[]
["Supplementary Figure 11A right panel"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["Typical",-2.03062845915892,0.131253008068102,0.629395660837416,-3.22631467852377,0.00125395407904808,0.0382266911397317,0.45066291675503]
["LCNEC",0.591294265269414,1.80632476655327,0.410203382303362,1.44146608920969,0.149453050893226,0.808407035593197,4.03609693954424]
["Reference is Atypical"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[25.77,2,2.52962562050352E-006,"Wald test"]
[47.1450570248371,2,5.78869866387423E-011,"Likelihood ratio test"]
[41.7510872119851,2,8.58749713520581E-010,"Score (logrank) test"]
[]
[]
["Supplementary Figure 11C  middle panel"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["AC->TC",-0.375194325456872,0.687155733963868,0.708274701363552,-0.529729954683624,0.596299176175784,0.171463093927807,2.75384627620349]
["TC->TC",-2.12641271174283,0.119264363033306,0.866520950405198,-2.45396572436995,0.0141290448055794,0.021823616576086,0.651770445111588]
["TC->AC",-1.42603145703809,0.240260516956182,1.11882588579447,-1.27457853375056,0.202458459422998,0.0268124244995257,2.15292414190567]
["LCNEC->LCNEC",0.828536344991106,2.28996456807726,0.528254075902625,1.56844288153459,0.116777810202919,0.813163877452721,6.4488080059289]
["Reference is AC->AC"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[25.18,4,4.62959324570608E-005,"Wald test"]
[44.0012341890747,4,6.41199072458872E-009,"Likelihood ratio test"]
[40.6498631986707,4,3.17601107495566E-008,"Score (logrank) test"]
[]
[]
["Supplementary Figure 11C  right panel"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["Typical",-1.04344977842283,0.352237442434028,0.540486166975538,-1.93057628886561,0.0535354724679711,0.122116081388199,1.01601045859022]
["LCNEC",1.06875089259215,2.91174015128879,0.392220322613581,2.72487382976607,0.0064326063432846,1.34987660728911,6.28074496798168]
["Reference is Atypical"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[26.82,2,1.49937239338826E-006,"Wald test"]
[35.6874790609967,2,1.78058366715922E-008,"Likelihood ratio test"]
[35.4618135936536,2,1.99326489905144E-008,"Score (logrank) test"]
[]
[]
["Supplementary Figure 12A middle panel"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["AC->TC",-2.94851965763603,0.0524172440097445,1.10213075080529,-2.6752902552457,0.00746645765444901,0.00604419944987028,0.454579219690718]
["TC->TC",-2.59097107252544,0.0749472255453639,0.693670228251999,-3.73516257005077,0.00018759396118323,0.0192443121036066,0.291882951529087]
["PCA->UC",-1.3257863427392,0.265594029018077,0.648440692437468,-2.04457610110126,0.0408966676460362,0.0745185831812447,0.946612042777125]
["LCNEC->LCNEC",0.0241519862484374,1.02444600776441,0.411657366491806,0.0586701179533444,0.953214860742799,0.457178384559211,2.29558014610927]
["Reference is AC->AC"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[28.79,4,8.64100177036011E-006,"Wald test"]
[51.04256680827,4,2.1869657563941E-010,"Likelihood ratio test"]
[46.3826978030365,4,2.05014807299288E-009,"Score (logrank) test"]
[]
[]
["Supplementary Figure 12A right panel"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["Typical",-1.63364630866727,0.195216455338316,0.585401275643164,-2.79064357499465,0.00526033640177414,0.0619757731819433,0.614909060077044]
["LCNEC",0.89800070487097,2.45469055110253,0.353014077905399,2.54380989619235,0.0109650743166023,1.2288832450856,4.90323692325408]
["Reference is Atypical"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[26.25,2,1.99382173008661E-006,"Wald test"]
[41.9849471592014,2,7.63984526987942E-010,"Likelihood ratio test"]
[38.7921547671688,2,3.77042773793428E-009,"Score (logrank) test"]
[]
[]
["Supplementary Figure 12B middle panel"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["AC->TC",-1.38512596333111,0.250292270157848,0.825636744666966,-1.67764573497734,0.0934162788310581,0.0496208462032362,1.26249802843313]
["TC->TC",-2.40110641618375,0.0906176369837621,0.692693266711352,-3.46633428037103,0.000527606868916023,0.0233126237968538,0.352236462273676]
["PCA->UC",-1.54206442761398,0.213938983678341,0.720946494788341,-2.13894434436041,0.0324401760907733,0.0520737866486999,0.878942970790545]
["LCNEC->LCNEC",0.326887385923218,1.3866453126056,0.410335135382551,0.796635134884232,0.425662965820718,0.62042242579429,3.09915493546104]
["Reference is AC->AC"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[29.82,4,5.3351580955948E-006,"Wald test"]
[49.8448506876123,4,3.89048575896365E-010,"Likelihood ratio test"]
[46.1658132712514,4,2.27473035916917E-009,"Score (logrank) test"]
[]
[]
["Supplementary Figure 12B right panel"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["Typical",-1.66471302959585,0.189244957892426,0.585463383089296,-2.84341101028677,0.00446334715344782,0.0600726765026373,0.596172106400715]
["LCNEC",0.944945901455732,2.57267419689467,0.3515957993707,2.68759155583495,0.00719693693033673,1.29153417873386,5.12464372399043]
["Reference is Atypical"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[28.32,2,7.08873276305581E-007,"Wald test"]
[45.9897345610344,2,1.03146863864153E-010,"Likelihood ratio test"]
[42.7099891687113,2,5.3167187969562E-010,"Score (logrank) test"]
[]
[]
["Supplementary Figure 26A"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["MEN1.mutated",0.537636174454329,1.7119553117932,0.671310258737841,0.80087585055703,0.423203521955619,0.459274248931228,6.38135274598381]
["Reference is Wild Type"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[0.64,1,0.4,"Wald test"]
[0.58,1,0.4,"Likelihood ratio test"]
[0.66,1,0.4,"Score (logrank) test"]
[]
["Supplementary Figure 26B"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["MEN1mutated",-0.513684550238143,0.598287093819817,0.821925933994121,-0.624976690712155,0.531986356605787,0.119477193066411,2.99594790808651]
["Reference is Wild Type"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[0.39,1,0.5,"Wald test"]
[0.39,1,0.5,"Likelihood ratio test"]
[0.4,1,0.5,"Score (logrank) test"]
[]
[]
["Supplementary Figure 31A"]
[]
["var","coef","exp.coef","se.coef","z","P.z","lower.95","upper.95"]
["Typical",-1.74008215299377,0.175505981682906,0.578886062574667,-3.00591474815362,0.00264783222610827,0.0564343091711035,0.545808924728585]
["LCNEC",1.01738702237445,2.76595792705876,0.335693516269903,3.03070203344783,0.00243985894902795,1.43252671785689,5.34057980133497]
["Reference is Atypical"]
[]
["Global statistics"]
["stat","df","pvalue","test"]
[32.9,2,7.17780169089103E-008,"Wald test"]
[54.8374375223357,2,1.23652169678549E-012,"Likelihood ratio test"]
[51.7140481609268,2,5.89436633025992E-012,"Score (logrank) test"]