Table S2. Integrative reference annotation for dual role genes
GENE ID	SOURCE
CBL	"COSMIC;POTSF;TSGDB"
EZH2	"COSMIC;POTSF;TSGDB"
FOXL2	"COSMIC;POTSF;TSGDB"
FOXO1	"COSMIC;POTSF;TSGDB"
FOXO3	"COSMIC;POTSF;TSGDB"
FOXO4	"COSMIC;POTSF;TSGDB"
KLF4	"COSMIC;POTSF;TSGDB"
NOTCH1	"COSMIC;POTSF;TSGDB"
NOTCH2	"COSMIC;POTSF;TSGDB"
PAX5	"COSMIC;POTSF;TSGDB"
RHOA	"COSMIC;POTSF;TSGDB"
RUNX1	"COSMIC;POTSF;TSGDB"
SUZ12	"COSMIC;POTSF;TSGDB"
TCF3	"COSMIC;POTSF;TSGDB"
WT1	"COSMIC;POTSF"
CREBBP	"COSMIC;TSGDB"
DDB2	"COSMIC;TSGDB"
GPC3	"COSMIC;TSGDB"
IRF4	"COSMIC;TSGDB"
MAP2K4	"COSMIC;TSGDB"
PRKAR1A	"COSMIC;TSGDB"
TP53	"COSMIC;TSGDB"
TP63	"COSMIC;TSGDB"
TRIM24	"COSMIC;TSGDB"
ARHGEF12	"POTSF;TSGDB"
BCR	"POTSF;TSGDB"
CDKN1B	"POTSF;TSGDB"
DNMT1	"POTSF;TSGDB"
DNMT3A	"POTSF;TSGDB"
ETV6	"POTSF;TSGDB"
FLT3	"POTSF;TSGDB"
FUS	"POTSF;TSGDB"
IDH1	"POTSF;TSGDB"
NCOA4	"POTSF;TSGDB"
NOTCH3	"POTSF;TSGDB"
NPM1	"POTSF;TSGDB"
NR4A3	"POTSF;TSGDB"
PML	"POTSF;TSGDB"
PTPN11	"POTSF;TSGDB"
RB1	"POTSF;TSGDB"
SPOP	"POTSF;TSGDB"
WHSC1L1	"POTSF;TSGDB"
ZBTB16	"POTSF;TSGDB"
APOBEC3B	COSMIC
ARNT	 COSMIC
ATP1A1	 COSMIC
BCL11B	 COSMIC
BCL9L	 COSMIC
BCORL1	 COSMIC
BIRC3	 COSMIC
BMPR1A	 COSMIC
BTK	 COSMIC
CBLC	 COSMIC
CDKN1A	 COSMIC
CIC	 COSMIC
CUX1	 COSMIC
DAXX	 COSMIC
ELF4	 COSMIC
EPAS1	 COSMIC
ERBB4	 COSMIC
ESR1	 COSMIC
FES	 COSMIC
GATA1	 COSMIC
GATA3	 COSMIC
HOXA11	 COSMIC
HOXA9	 COSMIC
IRS4	 COSMIC
JAK1	 COSMIC
KDM6A	 COSMIC
KMT2D	 COSMIC
LEF1	 COSMIC
MALAT1	 COSMIC
MAP3K1	 COSMIC
MAP3K13	 COSMIC
MKL1	 COSMIC
NFE2L2	 COSMIC
NFKB2	 COSMIC
NKX2-1	 COSMIC
NTRK1	 COSMIC
PABPC1	 COSMIC
POLQ	 COSMIC
PTK6	 COSMIC
QKI	 COSMIC
RAD21	 COSMIC
RECQL4	 COSMIC
RUNX1T1	 COSMIC
STAT5B	 COSMIC
TBL1XR1	 COSMIC
TBX3	 COSMIC
TERT	 COSMIC
TET1	 COSMIC
BCL10	POTSF
BRCA1	POTSF
BRCA2	POTSF
CAMTA1	POTSF
CBFA2T3	POTSF
CDC73	POTSF
CDH11	POTSF
CDX2	POTSF
CHEK2	POTSF
CREB3L1	POTSF
DCC	POTSF
DDX3	POTSF
DICER1	POTSF
EPHA1	POTSF
EPHA3	POTSF
EPHB4	POTSF
FAS	POTSF
FAT1	POTSF
FOXA1	POTSF
FOXP1	POTSF
IKZF2	POTSF
KLF5	POTSF
LIFR	POTSF
MAP3K4	POTSF
MST1R	POTSF
NF2	POTSF
NTRK3	POTSF
NUP98	POTSF
PHF6	POTSF
PPARG	POTSF
PRKCB	POTSF
PTPN1	POTSF
RHOB	POTSF
SH2B3	POTSF
SLC9A3R1	POTSF
SMAD4	POTSF
SOCS1	POTSF
STAT3	POTSF
SYK	POTSF
TCF7L2	POTSF
WT	POTSF
DMBT1	TSGDB
ECT2	TSGDB
ETS2	TSGDB
GLI1	TSGDB
HDAC1	TSGDB
HOPX	TSGDB
LHX4	TSGDB
LITAF	TSGDB
MAP3K8	TSGDB
MXI1	TSGDB
PHB	TSGDB
RARB	TSGDB
RASSF1	TSGDB
SALL4	TSGDB
SIRT1	TSGDB
SKIL	TSGDB
SPI1	TSGDB
WDR11	TSGDB
YAP1	TSGDB