This PDF file includes:

• Section S1. Depletion, diffusion, and concentration of hemoglobin near a growing fiber
• Section S2. Polymerization of deoxygenated HbS
• Section S3. Sensitivity analysis of RBC sickling criterion
• Section S4. Sickling of patient-specific RBCs in microfluidic channel under hypoxia
• Section S5. Determinants of RBC sickling time in the kinetic model
• Section S6. Model parameters
• Section S7. Model inputs
• Fig. S1. Detailed flow chart of the kinetic model.
• Fig. S2. Predicted nucleation barriers near a growing fiber.
• Fig. S3. Simulation of HbS polymerization in purified HbS solution.
• Fig. S4. Sensitivity of model predictions.
• Fig. S5. Evolution of fractions of sickled RBCs under hypoxia for seven SCD patients.
• Fig. S6. Cumulative contributions to the RBC sickling time factors 1 to 5.
• Table S1. Patient-specific RBC variables for seven SCD patients examined in (24).
• Table S2. The default values of model parameters and their varying ranges in the sensitivity analysis.
• Table S3. Three sets of model inputs following the in vivo study (20) (condition I), in vitro study (24) (condition II), and the screening assay (22) (condition III).
• References (40–45)

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