{"text_format":"2","workbook":"xlsx","n_sheets":2,"sheets":["Supplemental_table_2","Sheet1"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Supplemental_table_2","index":0,"n_rows":97,"n_cols":8,"rows_kept":97,"cut":false,"hidden":false,"merged":[]}
["Supplemental Table 2. Annotation and pathway analysis of metabolites in inflammation - metabolite interaction network from mouse lungs treated with Cd, RSV and Cd+RSV. Metabolites in bold are listed in Figure 6."]
["Treatment","m/z","RT (s)","KEGG ID","Adduct","Name","Pathway","Node"]
["Cd",175.0966,551,"C00327","M[1+]","L-Citrulline","Arginine and Proline Metabolism","X2383"]
["Cd",214.18029999999999,19.5,"C05452","M+H+Na[2+]","3alpha,7alpha-Dihydroxy-5beta-cholestane","Bile acid biosynthesis","X1612"]
["Cd",285.279,173,"C01530","M+H[1+]","Stearic acid","Fatty Acid Metabolism","X3758"]
["Cd",304.07929999999999,182,"C00864","M+HCOOK[1+]","Pantothenate","CoA Catabolism","X3917"]
["Cd",325.04320000000001,148,"C00105","M+H[1+]","UMP","Pyrimidine metabolism","X4679"]
["Cd",329.00549999999998,183,"C04582","M+HCOONa[1+]","S-Methyl-5-thio-D-ribulose 1-phosphate","Methionine and cysteine metabolism","X1956"]
["Cd",334.00630000000001,133,"C00627","M+HCOOK[1+]","Pyridoxine phosphate","Vitamin B6 (pyridoxine) metabolism","X3032"]
["Cd",348.07159999999999,137,"C00020","M+H[1+]","AMP"," Purine metabolism; Methionine and cysteine metabolism","X3426"]
["Cd",370.05239999999998,148,"C04257","M+HCOONa[1+]","N-Acetyl-D-mannosamine 6-phosphate","Aminosugars metabolism; Sialic acid metabolism","X2829"]
["Cd",371.03649999999999,155,"C00130","M+Na[1+]","IMP","Purine metabolism","X3577"]
["Cd",375.25060000000002,277,"C03242","M+HCOONa[1+]","(8Z,11Z,14Z)-Icosatrienoic acid","Fatty acid activation; De novo fatty acid biosynthesis","X3471"]
["Cd",378.1499,126,"C00255","M(C13)+H[1+]","Riboflavin","Vitamin B2 (riboflavin) metabolism","X2491"]
["Cd",405.22519999999997,80,"C02165","M+HCOONa[1+]","Leukotriene B4","Leukotriene metabolism; Arachidonic acid metabolism","X3775"]
["Cd",428.02809999999999,157,"C00224","M+H[1+]","Adenylyl sulfate","Methionine and cysteine metabolism","X658"]
["Cd",441.04649999999998,85,"C04352","M+K[1+]","(R)-4-Phosphopantothenoyl-L-cysteine","Vitamin B5 - CoA biosynthesis from pantothenate","X2915"]
["Cd",455.0598,128,"C05692","M+Na[1+]","Se-Adenosylselenohomocysteine","Selenoamino acid metabolism","X2916"]
["Cd",493.03399999999999,92,"C04823","M+K[1+]","1-(5-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole","Purine metabolism","X4039"]
["Cd",500.30489999999998,57,"C05465","M+H[1+]","Taurochenodeoxycholate","Bile acid biosynthesis","X463"]
["Cd",505.97629999999998,158,"C00063","M+Na[1+]","CTP","Pyrimidine metabolism","X1492"]
["Cd",506.96039999999999,154,"C00075","M+Na[1+]","UTP","Pyrimidine metabolism","X831"]
["Cd",560.07960000000003,369,"C00301","M+H[1+]","ADP-ribose","Pentose phosphate pathway","X138"]
["Cd",630.14549999999997,401,"C03691","M[1+]","CMP-N-glycoloylneuraminate","Aminosugars metabolism","X1311"]
["Cd",666.20590000000004,365,"chtn","M+K[1+]","chitin","Aminosugars metabolism","X1996"]
["Cd",674.2337,92,"C04886","M[1+]","alpha-N-Acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine","Aminosugars metabolism","X732"]
["Cd",712.49990000000003,41,"C01190","M+HCOONa[1+]","Glucosylceramide","Glycosphingolipid metabolism; Sialic acid metabolism","X2993"]
["Cd",728.28700000000003,356,"C11304","M+HCOOK[1+]","S-(PGA1)-glutathione","Prostaglandin formation from arachidonate","X4942"]
["Cd",918.12950000000001,217,"C05269","M+K[1+]","3-Oxohexanoyl-CoA","Saturated fatty acids beta-oxidation","X754"]
["Cd",970.26509999999996,75,"C03221","M+Na[1+]","2-trans-Dodecenoyl-CoA","Saturated fatty acids beta-oxidation","X2867"]
["Cd",1004.244,79,"C05262","M+K[1+]","(S)-3-Hydroxydodecanoyl-CoA","Saturated fatty acids beta-oxidation","X367"]
["Cd",1032.3642,345,"C00510","M+H[1+]","Oleoyl-CoA","De novo fatty acid biosynthesis","X2913"]
["Cd",1252.2348999999999,74,"CE6190","M+K[1+]","CoA-20-COOH-LTE4","Leukotriene metabolism","X1399"]
["RSV",135.01660000000001,57,"C00106","M+Na[1+]","Uracil","Pyrimidine metabolism","X4421"]
["RSV",190.99639999999999,69,"C00385","M+K[1+]","Xanthine","Purine metabolism","X2260"]
["RSV",193.08189999999999,107,"n.a.","M(C13)+2H[2+]","beta-1,4-mannose-N-acetylglucosamine","N-Glycan Degradation","X3188"]
["RSV",197.0044,68,"C00425","M+Na[1+]","Dehydroascorbate","Prostaglandin formation from arachidonate","X3324"]
["RSV",219.02680000000001,84,"C00738","M+K[1+]","D-Hexose","Hexose phosphorylation","X1831"]
["RSV",228.09809999999999,160,"C00881","M+H[1+]","Deoxycytidine","Pyrimidine metabolism","X3148"]
["RSV",244.07929999999999,87,"C01132","M+Na[1+]","N-Acetyl-D-galactosamine","Glycosphingolipid metabolism","X4220"]
["RSV",284.09899999999999,77,"C00387","M+H[1+]","Guanosine","Purine metabolism","X4520"]
["RSV",292.13350000000003,159,"C00500","M+2H[2+]","Biliverdin","Porphyrin metabolism","X4784"]
["RSV",321.08260000000001,155,"C05512","M+HCOONa[1+]","Deoxyinosine","Purine metabolism","X3759"]
["RSV",322.05500000000001,76,"C00364","M[1+]","dTMP","Pyrimidine metabolism","X4613"]
["RSV",330.0607,207,"C00575","M+H[1+]","3,5-Cyclic AMP","Purine metabolism","X608"]
["RSV",341.20920000000001,42,"C00249","M+HCOOK[1+]","Hexadecanoic acid","Phosphatidylinositol phosphate metabolism","X1938"]
["RSV",369.0444,163,"C01762","M+HCOOK[1+]","Xanthosine","Purine metabolism","X2805"]
["RSV",376.05119999999999,85,"C00239","M+HCOONa[1+]","dCMP","Pyrimidine metabolism","X4899"]
["RSV",380.09539999999998,116,"C15658","M+K[1+]","6-(alpha-D-Glucosaminyl)-1D-myo-inositol","Phosphatidylinositol phosphate metabolism","X518"]
["RSV",381.15499999999997,134,"C03374","M+2H[2+]","Bilirubin-glucuronoside","Porphyrin metabolism","X4720"]
["RSV",406.13200000000001,97,"n.a.","M+Na[1+]","beta-1,4-mannose-N-acetylglucosamine","Aminosugars metabolism","X3817"]
["RSV",411.11430000000001,90,"C00089","M+HCOONa[1+]","Sucrose","Galactose metabolism","X2277"]
["RSV",414.02839999999998,85,"C01344","M(C13)+H[1+]","dIDP","Purine metabolism","X614"]
["RSV",472.03149999999999,87,"C04549","M(C13)+H[1+]","1-Phosphatidyl-1D-myo-inositol 3-phosphate","Phosphatidylinositol phosphate metabolism","X4457"]
["RSV",482.99950000000001,270,"C00459","M+H[1+]","dTTP","Aminosugars metabolism","X962"]
["RSV",513.99400000000003,123,"C00131","M+Na[1+]","dATP","Pyrimidine metabolism","X3974"]
["RSV",564.26990000000001,59,"C02191","M(C13)+H[1+]","Protoporphyrin","Porphyrin metabolism","X1348"]
["RSV",576.9778,83,"C00081","M+HCOONa[1+]","ITP","Aminosugars metabolism","X1333"]
["RSV",660.31650000000002,58,"C03263","M[1+]","Coproporphyrinogen III","Porphyrin metabolism","X2644"]
["RSV",756.08659999999998,208,"C06197","M[1+]","P1,P3-Bis(5-adenosyl) triphosphate","Purine metabolism","X2862"]
["Cd+RSV",919.23419999999999,216,"C05275","M[1+]","trans-Dec-2-enoyl-CoA","Di-unsaturated fatty acid beta-oxidation","X843"]
["Cd+RSV",576.9778,83,"C00081","M+HCOONa[1+]","ITP","TCA cycle","X1965"]
["Cd+RSV",185.02379999999999,370,"C15606","M+Na[1+]","1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one","Methionine and cysteine metabolism","X1880"]
["Cd+RSV",307.03359999999998,206,"C00542","M+HCOOK[1+]","Cystathionine","Methionine and cysteine metabolism","X693"]
["Cd+RSV",155.02029999999999,126,"C00606","M(C13)+H[1+]","Cysteinesulfinic acid","Methionine and cysteine metabolism","X412"]
["Cd+RSV",217.0128,171,"C01180","M+HCOONa[1+]","4-Methylthio-2-oxobutanoic acid","Methionine and cysteine metabolism","X340"]
["Cd+RSV",170.01179999999999,134,"C00506","M+H[1+]","Cysteate","Methionine and cysteine metabolism","X4849"]
["Cd+RSV",329.00549999999998,183,"C04582","M+HCOONa[1+]","S-Methyl-5-thio-D-ribulose 1-phosphate","Methionine and cysteine metabolism","X4333"]
["Cd+RSV",179.0855,49,"C01137","M(C13)+2H[2+]","S-Adenosylmethioninamine","Methionine and cysteine metabolism","X225"]
["Cd+RSV",355.15499999999997,119,"C01137","M[1+]","S-Adenosylmethioninamine","Methionine and cysteine metabolism","X1030"]
["Cd+RSV",190.01259999999999,74,"C00097","M+HCOONa[1+]","Cysteine","Methionine and cysteine metabolism","X4053"]
["Cd+RSV",336.089,165,"C00212","M+HCOONa[1+]","Adenosine","Methionine and cysteine metabolism","X961"]
["Cd+RSV",195.0513,91,"C00191","M+H[1+]","Glucuronate","Phosphatidylinositol phosphate metabolism","X1981"]
["Cd+RSV",569.3125,50,"C01079","M+H[1+]","Protoporphyrinogen IX","Porphyrin metabolism","X765"]
["Cd+RSV",585.25070000000005,115,"C02191","M+Na[1+]","Protoporphyrin","Porphyrin metabolism","X3772"]
["Cd+RSV",564.26990000000001,59,"C02191","M(C13)+H[1+]","Protoporphyrin","Porphyrin metabolism","X628"]
["Cd+RSV",660.31650000000002,58,"C03263","M[1+]","Coproporphyrinogen III","Porphyrin metabolism","X2367"]
["Cd+RSV",493.03399999999999,92,"C04823","M+K[1+]","1-(5-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole","Purine metabolism","X4900"]
["Cd+RSV",153.0395,169,"C00385","M+H[1+]","Xanthine","Purine metabolism","X715"]
["Cd+RSV",336.089,165,"C00330","M+HCOONa[1+]","Deoxyguanosine","Purine metabolism","X961"]
["Cd+RSV",366.05950000000001,200,"C04734","M[1+]","1-(5-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide","Purine metabolism","X2241"]
["Cd+RSV",146.0385,577,"C00294","M+H+Na[2+]","Inosine","Purine metabolism","X3518"]
["Cd+RSV",190.99639999999999,69,"C00385","M+K[1+]","Xanthine","Purine metabolism","X3910"]
["Cd+RSV",354.05900000000003,208,"C00360","M+Na[1+]","dAMP","Purine metabolism","X3723"]
["Cd+RSV",288.06470000000002,96,"C03838","M(C13)+H[1+]","5-Phosphoribosylglycinamide","Purine metabolism; Vitamin B9 (folate) metabolism","X1057"]
["Cd+RSV",447.11059999999998,120,"C05276","M(C13)+2H[2+]","trans-Oct-2-enoyl-CoA","Saturated fatty acids beta-oxidation","X3646"]
["Cd+RSV",918.12950000000001,217,"C05269","M+K[1+]","3-Oxohexanoyl-CoA","Saturated fatty acids beta-oxidation","X478"]
["Cd+RSV",938.24260000000004,78,"C05265","M(S34)+H[1+]","3-Oxodecanoyl-CoA","Saturated fatty acids beta-oxidation","X261"]
["Cd+RSV",374.19540000000001,119,"C05552","M(C13)+H[1+]","N6-D-Biotinyl-L-lysine","Vitamin H (biotin) metabolism","X3855"]
["Cd+RSV",287.57810000000001,144.5,"C05921","M+2H[2+]","Biotinyl-5-AMP","De novo fatty acid biosynthesis","X1070"]
["Cd+RSV",401.02460000000002,145,"C14868","M[1+]","S-(1,2-Dichlorovinyl)glutathione","Xenobiotics metabolism","X1376"]
["Cd+RSV",723.15660000000003,119,"C14863","M+HCOONa[1+]","2-(S-Glutathionyl)acetyl glutathione","Xenobiotics metabolism","X2063"]
["Cd+RSV",231.06299999999999,75,"C06205","M+HCOONa[1+]","1,2-Dihydronaphthalene-1,2-diol","Xenobiotics metabolism","X1733"]
["Cd+RSV",339.07940000000002,158,"C14863","M+H+Na[2+]","2-(S-Glutathionyl)acetyl glutathione","Xenobiotics metabolism","X2323"]
["Cd+RSV",373.0729,211,"C14874","M+K[1+]","Glutathione episulfonium ion","Xenobiotics metabolism","X4894"]
["Cd+RSV",434.06259999999997,161,"C14871","M+HCOOK[1+]","S-(Formylmethyl)glutathione","Xenobiotics metabolism","X1338"]
["Cd+RSV",243.10890000000001,143,"C06213","M+HCOONa[1+]","Methyltryptamine","Tryptophan metabolism","X4820"]

{"sheet":"Sheet1","index":1,"n_rows":0,"n_cols":0,"rows_kept":0,"cut":false,"hidden":false,"merged":[]}