This PDF file includes:

• Fig. S1. Biochemical characterization of TtClpP.
• Fig. S2. Characterization of GFPssrA degradation by TtClpXP.
• Fig. S3. Characterization of TtClpP peptidase activity in the absence and presence of bortezomib.
• Fig. S4. Characterization of FITC-casein degradation by TtClpP in the absence and presence of bortezomib and/or TtClpX.
• Fig. S5. Ligand validation by 2mF_o-DF_c, omit, and polder maps.
• Fig. S6. Distance RMSD of the 14 alanine tripeptide ligands with respect to their initial bound state in TtClpP for three independent, 1-μs-long MD simulations.
• Fig. S7. Analysis of structural differences between TtClpP and EcClpP.
• Table S1. Crystallographic data collection and refinement statistics.
• Reference (65)

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