This PDF file includes:

• Fig. S1. iP300w protects 293T cells from DUX4-induced toxicity.
• Fig. S2. Doxycycline effect on morphology and viability of parent cell lines.
• Fig. S3. iP300w inactivates induction of DUX4 target genes.
• Fig. S4. iP300w inactivates induction of DUX4 target genes in different cell types.
• Fig. S5. Dose- and time-dependent DUX4 inactivation by iP300w in FSHD myoblasts.
• Fig. S6. Effect of doxycycline on profibrotic gene expression in wild-type mice.
• Fig. S7. Low levels of DUX4 induce H3 acetylation through p300 in human myoblasts.
• Fig. S8. DUX4 induces H3 acetylation in nonmyogenic cells.
• Fig. S9. Low levels of DUX4 induce H3 acetylation through p300 in mouse myoblasts.

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