The PDF file includes:

• Fig. S1. X. laevis and human Bap1 proteins show extensive sequence homology.
• Fig. S2. Anatomic distribution of Xenopus bap1 mRNA and Bap1 protein expression during early development.
• Fig. S3. Bap1 morpholinos and expression constructs.
• Fig. S4. Developmental abnormalities in Bap1-deficient embryos are rescued by exogenous human BAP1.
• Fig. S5. Loss of Asxl1 phenocopy loss of Bap1 during Xenopus development.
• Fig. S6. Pharmacologic rescue of Bap1-deficient phenotype.
• Fig. S7. Hdac4 is a key mediator of Bap1-deficient phonotype and acts independently of Hdac3 during development.
• Fig. S8. Inhibition of HDAC4 significantly impairs proliferation of uveal melanoma cells in a BAP1-dependent manner.
• Legends for data files S1 and S2

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Other Supplementary Material for this manuscript includes the following:

• Data file S1 (Microsoft Excel format). Oligonucleotides and plasmids used in this study.
• Data file S2 (Microsoft Excel format). Proteomic, transcriptomic, and epigenomic analyses.