The PDF file includes:

• Fig. S1. Mean coverage of the coding regions of CSDE1 in ExAC whole-exome sequencing data.
• Fig. S2. Correlations of the two independent HITS-CLIP experiments and pathway enrichment of Csde1-binding targets.
• Fig. S3. Time-spatial expression pattern of CSDE1 in human and mouse brain.
• Fig. S4. CSDE1 disruptive mutations show loss of function.
• Fig. S5. Interfere efficiency of two shRNA in neurons.
• Fig. S6. Immunoblotting with anti-dUnr antibodies was performed to examine the expression level of dUnr in dunr, dunr/Df1, dunr/Df2, and Da-RNAi lines.
• Fig. S7. Overexpression of dUnr or hCSDE1 has no effect on both bouton number and satellite bouton number compared to WT controls.

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Other Supplementary Material for this manuscript includes the following:

• Table S1 (Microsoft Excel format). Detailed clinical information for probands or carrier patients with LGD mutation or de novo missense mutations.
• Table S2 (Microsoft Excel format). Validation result of selected RNA binding targets.
• Table S3 (Microsoft Excel format). High-confidence RNA binding targets called by two software programs in two experiments.