Biochemical Average.heritability Confidence.interval.of.heritability Common.environmental.component Confidence.interval.of.environmental.component N-acetylaspartate (NAA) 0.33 (0.25,0.43) 0.51 (0.42,0.59) alanine 0.57 (0.41,0.72) 0.08 (0.01,0.37) creatine 0.7 (0.66,0.74) 0 (0.00,1.00) creatinine 0.68 (0.51,0.81) 0.02 (0.00,0.99) guanidinoacetate 0.61 (0.44,0.76) 0.04 (0.00,0.60) glutamate 0.43 (0.32,0.56) 0.34 (0.24,0.45) glutamine 0.53 (0.37,0.68) 0.13 (0.04,0.34) 5-oxoproline 0.49 (0.35,0.62) 0.22 (0.12,0.37) cysteinylglycine 0.18 (0.08,0.33) 0.52 (0.42,0.62) N-acetylglycine 0.72 (0.68,0.76) 0 (0.00,1.00) N-acetylserine 0.58 (0.40,0.74) 0.02 (0.00,1.00) dimethylglycine 0.75 (0.58,0.87) 0.01 (0.00,1.00) glycine 0.77 (0.74,0.81) 0 (0.00,0.00) 1-methylimidazoleacetate 0.46 (0.31,0.62) 0.18 (0.08,0.37) histidine 0.55 (0.39,0.69) 0.11 (0.03,0.33) imidazole propionate 0.27 (0.11,0.55) 0.06 (0.00,0.61) trans-urocanate 0.52 (0.45,0.58) 0 (0.00,0.00) 2-methylbutyrylcarnitine (C5) 0.51 (0.35,0.67) 0.11 (0.03,0.35) 3-methylglutaconate 0.58 (0.53,0.64) 0 (0.00,1.00) isobutyrylcarnitine 0.51 (0.36,0.66) 0.16 (0.07,0.35) isovalerate 0.17 (0.11,0.26) 0.67 (0.60,0.73) isovalerylcarnitine 0.44 (0.29,0.60) 0.19 (0.09,0.37) methylsuccinate 0.55 (0.39,0.70) 0.11 (0.03,0.34) tiglylcarnitine 0.43 (0.26,0.61) 0.13 (0.04,0.36) valine 0.57 (0.43,0.71) 0.14 (0.05,0.32) 3-methylglutarylcarnitine (1) 0.6 (0.42,0.75) 0.05 (0.00,0.51) 3-methylglutarylcarnitine (2) 0.72 (0.55,0.85) 0.01 (0.00,1.00) 5-hydroxylysine 0.6 (0.47,0.72) 0.18 (0.09,0.33) N6-acetyllysine 0.46 (0.32,0.60) 0.25 (0.14,0.40) 2-hydroxybutyrate/2-hydroxyisobutyrate 0.42 (0.25,0.60) 0.13 (0.04,0.37) N-acetyltaurine 0.39 (0.25,0.55) 0.25 (0.14,0.41) S-methylcysteine 0.48 (0.31,0.65) 0.1 (0.02,0.38) cystathionine 0.41 (0.24,0.60) 0.11 (0.03,0.38) methionine sulfoxide 0.1 (0.06,0.18) 0.75 (0.69,0.80) N-acetylphenylalanine 0.43 (0.28,0.59) 0.21 (0.10,0.38) o-cresol sulfate 0.36 (0.24,0.51) 0.33 (0.22,0.46) p-cresol sulfate 0.5 (0.43,0.56) 0 (0.00,1.00) phenol sulfate 0.31 (0.14,0.56) 0.07 (0.00,0.56) phenylacetate 0.4 (0.23,0.60) 0.1 (0.02,0.39) phenylacetylglutamine 0.39 (0.23,0.59) 0.13 (0.04,0.37) thyroxine 0.61 (0.44,0.76) 0.01 (0.00,1.00) tyramine O-sulfate 0.32 (0.14,0.59) 0.13 (0.02,0.47) tyrosine 0.51 (0.36,0.65) 0.17 (0.07,0.34) vanillylmandelate (VMA) 0.57 (0.40,0.73) 0.05 (0.00,0.53) 5-methylthioadenosine (MTA) 0.27 (0.13,0.49) 0.22 (0.10,0.40) 3-indoxyl sulfate 0.3 (0.13,0.53) 0.13 (0.03,0.40) 5-hydroxyindoleacetate 0.42 (0.24,0.62) 0.09 (0.01,0.41) anthranilate 0.33 (0.17,0.54) 0.17 (0.06,0.40) indoleacetylglutamine 0.12 (0.01,0.70) 0.2 (0.05,0.53) indolepropionate 0.46 (0.33,0.58) 0 (0.00,1.00) tryptophan 0.31 (0.19,0.47) 0.34 (0.23,0.47) arginine 0.78 (0.74,0.81) 0 (0.00,0.00) citrulline 0.74 (0.70,0.78) 0 (0.00,0.00) homocitrulline 0.31 (0.17,0.51) 0.23 (0.11,0.40) pro-hydroxy-pro 0.51 (0.34,0.67) 0.11 (0.03,0.36) sucrose 0.17 (0.03,0.62) 0.13 (0.02,0.53) mannitol/sorbitol 0.38 (0.22,0.58) 0.13 (0.03,0.38) mannose 0.54 (0.40,0.67) 0.19 (0.09,0.35) 1,5-anhydroglucitol (1,5-AG) 0.63 (0.58,0.68) 0 (0.00,1.00) glycerate 0.52 (0.36,0.68) 0.11 (0.03,0.34) lactate 0.44 (0.31,0.58) 0.27 (0.16,0.41) oxalate (ethanedioate) 0.41 (0.28,0.56) 0.28 (0.17,0.42) bilirubin (Z,Z) 0.57 (0.43,0.71) 0.16 (0.07,0.33) nicotinamide 0.28 (0.14,0.47) 0.29 (0.17,0.45) pantothenate 0.3 (0.13,0.55) 0.06 (0.00,0.65) pyridoxate 0.3 (0.23,0.38) 0 (0.00,0.31) cis-aconitate 0.39 (0.22,0.59) 0.11 (0.02,0.38) citrate 0.68 (0.51,0.81) 0.01 (0.00,1.00) fumarate 0.64 (0.47,0.78) 0.03 (0.00,0.84) carnitine 0.77 (0.61,0.87) 0 (0.00,1.00) oleoyl ethanolamide 0.42 (0.27,0.60) 0.15 (0.05,0.35) acetylcarnitine 0.5 (0.34,0.66) 0.12 (0.03,0.35) cis-4-decenoyl carnitine 0.53 (0.37,0.68) 0.12 (0.04,0.34) hexanoylcarnitine 0.73 (0.69,0.77) 0 (0.00,0.00) myristoylcarnitine 0.42 (0.26,0.61) 0.12 (0.03,0.36) malonate 0.18 (0.07,0.39) 0.41 (0.29,0.54) 15-methylpalmitate 0.46 (0.29,0.64) 0.07 (0.01,0.42) 17-methylstearate 0.38 (0.22,0.57) 0.15 (0.05,0.37) 3-methyladipate 0.53 (0.36,0.69) 0.07 (0.01,0.41) hexadecanedioate 0.48 (0.33,0.63) 0.18 (0.08,0.35) 3-hydroxysebacate 0.49 (0.31,0.68) 0.01 (0.00,1.00) 5-hydroxyhexanoate 0.42 (0.36,0.49) 0 (0.00,0.04) 10-nonadecenoate (19:1n9) 0.42 (0.26,0.59) 0.16 (0.06,0.35) arachidate (20:0) 0.31 (0.15,0.53) 0.15 (0.05,0.38) margarate (17:0) 0.42 (0.26,0.59) 0.17 (0.07,0.36) myristoleate (14:1n5) 0.49 (0.34,0.65) 0.14 (0.05,0.34) oleate/vaccenate (18:1) 0.32 (0.19,0.49) 0.3 (0.19,0.44) palmitate (16:0) 0.28 (0.15,0.47) 0.3 (0.19,0.45) palmitoleate (16:1n7) 0.41 (0.26,0.57) 0.21 (0.10,0.37) 1-palmityl-GPC (O-16:0) 0.3 (0.16,0.50) 0.25 (0.13,0.41) 1-arachidoyl-GPC (20:0) 0.58 (0.40,0.74) 0 (0.00,1.00) 1-linoleoyl-GPC (18:2) 0.55 (0.37,0.72) 0.03 (0.00,0.84) 1-margaroyl-GPC (17:0) 0.42 (0.27,0.59) 0.18 (0.08,0.36) 1-myristoyl-GPC (14:0) 0.39 (0.22,0.59) 0.12 (0.03,0.39) 1-nonadecanoyl-GPC (19:0) 0.55 (0.38,0.72) 0.04 (0.00,0.60) 1-palmitoyl-GPA (16:0) 0.48 (0.27,0.70) 0.14 (0.03,0.47) 1-palmitoyl-GPE (16:0) 0.62 (0.45,0.77) 0.02 (0.00,0.98) 1-stearoyl-GPC (18:0) 0.5 (0.34,0.66) 0.12 (0.03,0.34) 1-stearoyl-GPE (18:0) 0.66 (0.50,0.80) 0.04 (0.00,0.59) 1-stearoyl-GPI (18:0) 0.3 (0.16,0.49) 0.27 (0.15,0.43) 1-palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6) 0.59 (0.41,0.75) 0.02 (0.00,1.00) 1-palmitoyl-2-linoleoyl-GPC (16:0/18:2) 0.49 (0.34,0.65) 0.14 (0.04,0.35) 1-palmitoyl-2-linoleoyl-GPI (16:0/18:2) 0.54 (0.37,0.70) 0.08 (0.01,0.39) 1-palmitoyl-2-oleoyl-GPC (16:0/18:1) 0.42 (0.25,0.61) 0.12 (0.03,0.37) 1-stearoyl-2-arachidonoyl-GPI (18:0/20:4) 0.53 (0.38,0.67) 0.15 (0.06,0.34) 1-stearoyl-2-docosahexaenoyl-GPC (18:0/22:6) 0.58 (0.40,0.74) 0.04 (0.00,0.64) 1-stearoyl-2-linoleoyl-GPI (18:0/18:2) 0.63 (0.46,0.77) 0.04 (0.00,0.66) 1-stearoyl-2-oleoyl-GPE (18:0/18:1) 0.38 (0.24,0.54) 0.26 (0.15,0.42) choline 0.26 (0.13,0.46) 0.28 (0.17,0.44) choline phosphate 0.39 (0.24,0.56) 0.21 (0.10,0.39) 1-(1-enyl-stearoyl)-2-oleoyl-GPE (P-18:0/18:1) 0.6 (0.42,0.75) 0.01 (0.00,1.00) adrenate (22:4n6) 0.35 (0.19,0.55) 0.15 (0.05,0.37) chenodeoxycholate 0.59 (0.41,0.75) 0.02 (0.00,0.97) cholate 0.54 (0.47,0.60) 0 (0.00,1.00) glycochenodeoxycholate 0.55 (0.50,0.61) 0 (0.00,1.00) deoxycholate 0.42 (0.23,0.63) 0.01 (0.00,1.00) glycoursodeoxycholate 0.43 (0.36,0.50) 0 (0.00,1.00) taurolithocholate 3-sulfate 0.34 (0.17,0.55) 0.14 (0.04,0.38) ursodeoxycholate 0.38 (0.31,0.45) 0 (0.00,1.00) sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) 0.52 (0.37,0.67) 0.14 (0.05,0.34) sphingomyelin (d18:1/18:1, d18:2/18:0) 0.5 (0.36,0.65) 0.18 (0.08,0.35) 4-androsten-3alpha,17alpha-diol monosulfate (2) 0.62 (0.55,0.68) 0 (0.00,1.00) 4-androsten-3beta,17beta-diol monosulfate (1) 0.71 (0.54,0.84) 0.03 (0.00,0.89) 5alpha-pregnan-3beta,20alpha-diol disulfate 0.56 (0.50,0.62) 0 (0.00,0.00) 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) 0.49 (0.42,0.56) 0 (0.00,1.00) cortisone 0.51 (0.34,0.68) 0.07 (0.01,0.41) etiocholanolone glucuronide 0.74 (0.69,0.77) 0 (0.00,1.00) 7-alpha-hydroxy-3-oxo-4-cholestenoate (7-Hoca) 0.28 (0.15,0.46) 0.31 (0.20,0.46) cholesterol 0.5 (0.34,0.66) 0.15 (0.05,0.36) hypoxanthine 0.46 (0.34,0.59) 0.27 (0.17,0.40) inosine 0.58 (0.43,0.71) 0.15 (0.06,0.34) xanthine 0.6 (0.45,0.73) 0.13 (0.04,0.32) N1-methyladenosine 0.61 (0.44,0.76) 0.02 (0.00,0.98) guanosine 0.41 (0.27,0.55) 0.29 (0.18,0.43) orotidine 0.61 (0.46,0.74) 0.12 (0.04,0.33) 5,6-dihydrothymine 0.23 (0.09,0.49) 0.18 (0.07,0.40) 3-ureidopropionate 0.5 (0.44,0.57) 0 (0.00,0.15) N-acetyl-beta-alanine 0.29 (0.17,0.44) 0.39 (0.29,0.51) uridine 0.55 (0.40,0.70) 0.11 (0.03,0.34) alpha-glutamyltyrosine 0.51 (0.35,0.68) 0.1 (0.02,0.36) cyclo(leu-pro) 0.54 (0.36,0.70) 0.05 (0.00,0.53) glycylphenylalanine 0.56 (0.41,0.70) 0.14 (0.05,0.33) histidyltryptophan 0.12 (0.02,0.48) 0.3 (0.17,0.48) isoleucylvaline 0.39 (0.24,0.56) 0.22 (0.11,0.38) leucylphenylalanine/isoleucylphenylalanine 0.63 (0.48,0.76) 0.15 (0.06,0.33) prolylproline 0.45 (0.33,0.59) 0.28 (0.17,0.41) serylalanine 0.44 (0.31,0.57) 0.29 (0.18,0.42) gamma-glutamyl-epsilon-lysine 0.54 (0.40,0.67) 0.18 (0.09,0.34) gamma-glutamylglutamine 0.53 (0.40,0.65) 0.24 (0.14,0.38) gamma-glutamylglycine 0.34 (0.26,0.44) 0.49 (0.40,0.57) gamma-glutamyltyrosine 0.42 (0.26,0.61) 0.13 (0.04,0.36) 4-methylcatechol sulfate 0.27 (0.19,0.35) 0 (0.00,1.00) 4-vinylphenol sulfate 0.38 (0.20,0.59) 0.09 (0.02,0.41) hippurate 0.49 (0.43,0.55) 0 (0.00,1.00) methyl-4-hydroxybenzoate sulfate 0.46 (0.28,0.65) 0.04 (0.00,0.72) 3-hydroxypyridine sulfate 0.28 (0.14,0.47) 0.3 (0.18,0.46) 2-acetamidophenol sulfate 0.26 (0.09,0.55) 0.08 (0.01,0.54) 4-acetylphenol sulfate 0.41 (0.34,0.49) 0 (0.00,1.00) cinnamoylglycine 0.42 (0.26,0.61) 0.14 (0.04,0.37) ergothioneine 0.41 (0.26,0.58) 0.19 (0.09,0.38) 1,7-dimethylurate 0.5 (0.43,0.56) 0 (0.00,0.00) 1-methylxanthine 0.35 (0.21,0.53) 0.24 (0.12,0.41) 5-acetylamino-6-formylamino-3-methyluracil 0.73 (0.54,0.86) 0.02 (0.00,1.00) 7-methylxanthine 0.3 (0.15,0.52) 0.18 (0.07,0.39) caffeine 0.55 (0.49,0.61) 0 (0.00,1.00)