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{"sheet":"RNA_Seq_S288C_YPD_MCHM","index":0,"n_rows":118,"n_cols":8,"rows_kept":118,"cut":false,"hidden":false,"merged":[]}
["SGD","gene name","ORF","comparison","state","log2FoldChange","padj","description"]
["S000000349","ADH5","YBR145W","S288C YPD + MCHM/ S288C YPD","Up",3.4,0.0026,"Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication"]
["S000005419","ARG1","YOL058W","S288C YPD + MCHM/ S288C YPD","Up",2.632,0.0026,"Arginosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate"]
["S000004666","ARG7","YMR062C","S288C YPD + MCHM/ S288C YPD","Up",2.627,0.0026,"Mitochondrial ornithine acetyltransferase; catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine"]
["S000006349","ASN1","YPR145W","S288C YPD + MCHM/ S288C YPD","Up",1.739,0.0026,"Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication"]
["S000001251","BAT1","YHR208W","S288C YPD + MCHM/ S288C YPD","Up",2.252,0.0026,"Mitochondrial branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA biosynthesis; homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase; BAT1 has a paralog, BAT2, that arose from the whole genome duplication"]
["S000006032","CAR1","YPL111W","S288C YPD + MCHM/ S288C YPD","Up",3.072,0.0026,"Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance"]
["S000005376","CMK2","YOL016C","S288C YPD + MCHM/ S288C YPD","Up",2.947,0.0026,"Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication"]
["S000005829","CPA1","YOR303W","S288C YPD + MCHM/ S288C YPD","Up",1.939,0.0026,"Small subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader"]
["S000003870","CPA2","YJR109C","S288C YPD + MCHM/ S288C YPD","Up",2.81,0.0026,"Large subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor"]
["S000001579","CWP1","YKL096W","S288C YPD + MCHM/ S288C YPD","Down",-3.368,0.0026,"Cell wall mannoprotein that localizes to birth scars of daughter cells; linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance"]
["S000005056","DBP2","YNL112W","S288C YPD + MCHM/ S288C YPD","Down",-2.623,0.0026,"ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; interacts with YRA1; required for the assembly of Yra1p, Nab2p and Mex67p onto mRNA and formation of nuclear mRNP; involved in mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites"]
["S000000797","DLD3","YEL071W","S288C YPD + MCHM/ S288C YPD","Up",2.155,0.0026,"D-lactate dehydrogenase; part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm"]
["S000000947","FTR1","YER145C","S288C YPD + MCHM/ S288C YPD","Down",-1.911,0.0026,"High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress"]
["S000005902","GDH1","YOR375C","S288C YPD + MCHM/ S288C YPD","Up",2.041,0.0026,"NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication"]
["S000002357","GGC1","YDL198C","S288C YPD + MCHM/ S288C YPD","Up",2.188,0.0026,"Mitochondrial GTP/GDP transporter; essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family"]
["S000005511","GRE2","YOL151W","S288C YPD + MCHM/ S288C YPD","Up",3.574,0.0026,"3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase"]
["S000000535","HIS4","YCL030C","S288C YPD + MCHM/ S288C YPD","Up",2.702,0.0026,"Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis"]
["S000001378","HIS5","YIL116W","S288C YPD + MCHM/ S288C YPD","Up",2.584,0.0026,"Histidinol-phosphate aminotransferase; catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts"]
["S000002565","HOM2","YDR158W","S288C YPD + MCHM/ S288C YPD","Up",1.835,0.0026,"Aspartic beta semi-aldehyde dehydrogenase; catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis"]
["S000000854","HOM3","YER052C","S288C YPD + MCHM/ S288C YPD","Up",1.936,0.0026,"Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis"]
["S000004613","HXT2","YMR011W","S288C YPD + MCHM/ S288C YPD","Down",-2.879,0.0026,"High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose"]
["S000001134","HXT4","YHR092C","S288C YPD + MCHM/ S288C YPD","Down",-5.285,0.0026,"High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication"]
["S000000515","ILV6","YCL009C","S288C YPD + MCHM/ S288C YPD","Up",1.978,0.0026,"Regulatory subunit of acetolactate synthase; acetolactate synthase catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria"]
["S000002977","LEU1","YGL009C","S288C YPD + MCHM/ S288C YPD","Up",2.15,0.0026,"Isopropylmalate isomerase; catalyzes the second step in the leucine biosynthesis pathway"]
["S000000523","LEU2","YCL018W","S288C YPD + MCHM/ S288C YPD","Up",3.069,0.0026,"Beta-isopropylmalate dehydrogenase (IMDH); catalyzes the third step in the leucine biosynthesis pathway; can additionally catalyze the conversion of &#946;-ethylmalate into &#945;-ketovalerate"]
["S000001473","LYS1","YIR034C","S288C YPD + MCHM/ S288C YPD","Up",2.876,0.0026,"Saccharopine dehydrogenase (NAD+, L-lysine-forming); catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity"]
["S000000319","LYS2","YBR115C","S288C YPD + MCHM/ S288C YPD","Up",1.993,0.0026,"Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p"]
["S000001512","MAE1","YKL029C","S288C YPD + MCHM/ S288C YPD","Up",1.833,0.0026,"Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids"]
["S000001926","MET10","YFR030W","S288C YPD + MCHM/ S288C YPD","Up",2.273,0.0026,"Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide"]
["S000004294","MET17","YLR303W","S288C YPD + MCHM/ S288C YPD","Up",3.371,0.0026,"O-acetyl homoserine-O-acetyl serine sulfhydrylase; required for Methionine and cysteine biosynthesis"]
["S000005425","MET22","YOL064C","S288C YPD + MCHM/ S288C YPD","Up",2.107,0.0026,"Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway"]
["S000003898","MET5","YJR137C","S288C YPD + MCHM/ S288C YPD","Up",2.543,0.0026,"Sulfite reductase beta subunit; involved in amino acid biosynthesis, transcription repressed by methionine"]
["S000000893","MET6","YER091C","S288C YPD + MCHM/ S288C YPD","Up",2.617,0.0026,"Cobalamin-independent methionine synthase; involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs"]
["S000001113","PCL5","YHR071W","S288C YPD + MCHM/ S288C YPD","Up",2.306,0.0026,"Cyclin; interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity"]
["S000005175","PDR16","YNL231C","S288C YPD + MCHM/ S288C YPD","Up",2.643,0.0026,"Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress"]
["S000000296","PHO3","YBR092C","S288C YPD + MCHM/ S288C YPD","Down",-2.302,0.0026,"Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin"]
["S000002197","PRM7","YDL039C","S288C YPD + MCHM/ S288C YPD","Down",-2.137,0.0026,"Pheromone-regulated protein; predicted to have one transmembrane segment; promoter contains Gcn4p binding elements"]
["S000000460","RIB5","YBR256C","S288C YPD + MCHM/ S288C YPD","Up",2.412,0.0026,"Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway"]
["S000002418","SNQ2","YDR011W","S288C YPD + MCHM/ S288C YPD","Up",3.285,0.0026,"Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species"]
["S000001701","SRY1","YKL218C","S288C YPD + MCHM/ S288C YPD","Up",3.437,0.0026,"3-hydroxyaspartate dehydratase; deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity"]
["S000001694","TRP3","YKL211C","S288C YPD + MCHM/ S288C YPD","Up",1.947,0.0026,"Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p"]
["S000002994","TRP5","YGL026C","S288C YPD + MCHM/ S288C YPD","Up",1.896,0.0026,"Tryptophan synthase; catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis"]
["NA","YDR133C,YDR134C","NA","S288C YPD + MCHM/ S288C YPD","Down",-2.825,0.0026,"NA"]
["NA","YGL117W","NA","S288C YPD + MCHM/ S288C YPD","Up",3.707,0.0026,"NA"]
["S000001071","YHI9","YHR029C","S288C YPD + MCHM/ S288C YPD","Up",4.292,0.0026,"Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production"]
["NA","YIR017W-A","NA","S288C YPD + MCHM/ S288C YPD","Up","Inf",0.0026,"NA"]
["NA","YLR152C","NA","S288C YPD + MCHM/ S288C YPD","Up",2.643,0.0026,"NA"]
["NA","YMR102C","NA","S288C YPD + MCHM/ S288C YPD","Up",2.276,0.0026,"NA"]
["S000003486","ENO1","YGR254W","S288C YPD + MCHM/ S288C YPD","Up",2.069,0.0046,"Enolase I, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression repressed in response to glucose; protein abundance increases in response to DNA replication stress; N-terminally propionylated in vivo; ENO1 has a paralog, ENO2, that arose from the whole genome duplication"]
["S000002224","IDP1","YDL066W","S288C YPD + MCHM/ S288C YPD","Up",2.13,0.0046,"Mitochondrial NADP-specific isocitrate dehydrogenase; catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes"]
["S000003023","OLE1","YGL055W","S288C YPD + MCHM/ S288C YPD","Down",-2.083,0.0046,"Delta(9) fatty acid desaturase; required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria"]
["S000003170","ARO8","YGL202W","S288C YPD + MCHM/ S288C YPD","Up",1.715,0.0063,"Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis"]
["S000004801","GCV2","YMR189W","S288C YPD + MCHM/ S288C YPD","Up",1.928,0.0063,"P subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm"]
["S000004089","ICT1","YLR099C","S288C YPD + MCHM/ S288C YPD","Up",1.831,0.0063,"Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication"]
["S000005048","LEU4","YNL104C","S288C YPD + MCHM/ S288C YPD","Up",1.71,0.0063,"Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication"]
["S000003834","OPI3","YJR073C","S288C YPD + MCHM/ S288C YPD","Up",1.839,0.0063,"Methylene-fatty-acyl-phospholipid synthase; catalyzes the last two steps in phosphatidylcholine biosynthesis; also known as phospholipid methyltransferase"]
["S000005575","RSB1","YOR049C","S288C YPD + MCHM/ S288C YPD","Up",4.947,0.0063,"Suppressor of sphingoid LCB sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport long chain bases (LCBs) from the cytoplasmic side toward the extracytoplasmic side of the membrane"]
["S000003192","SDT1","YGL224C","S288C YPD + MCHM/ S288C YPD","Up",1.819,0.0063,"Pyrimidine nucleotidase; responsible for production of nicotinamide riboside and nicotinic acid riboside; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives; SDT1 has a paralog, PHM8, that arose from the whole genome duplication"]
["S000000977","TMT1","YER175C","S288C YPD + MCHM/ S288C YPD","Up",2.681,0.0063,"Trans-aconitate methyltransferase; cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle"]
["S000003951","TPO1","YLL028W","S288C YPD + MCHM/ S288C YPD","Up",1.757,0.0063,"Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane"]
["S000003224","ZRT1","YGL255W","S288C YPD + MCHM/ S288C YPD","Down",-2.13,0.0063,"High-affinity zinc transporter of the plasma membrane; responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor"]
["S000000871","ARG5,6","YER069W","S288C YPD + MCHM/ S288C YPD","Up",1.907,0.008,"Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine"]
["S000006342","MEP3","YPR138C","S288C YPD + MCHM/ S288C YPD","Up",1.767,0.008,"Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease; MEP3 has a paralog, MEP1, that arose from the whole genome duplication"]
["S000000892","TRP2","YER090W","S288C YPD + MCHM/ S288C YPD","Up",1.676,0.008,"Anthranilate synthase; catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p"]
["S000005901","ALD4","YOR374W","S288C YPD + MCHM/ S288C YPD","Down",-2.145,0.0094,"Mitochondrial aldehyde dehydrogenase; required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; can substitute for cytosolic NADP-dependent aldehyde dehydrogenase when directed to the cytosol"]
["S000003786","BNA1","YJR025C","S288C YPD + MCHM/ S288C YPD","Up",2.256,0.0094,"3-hydroxyanthranilic acid dioxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p"]
["S000002534","ARO1","YDR127W","S288C YPD + MCHM/ S288C YPD","Up",1.532,0.0108,"Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids"]
["NA","YOR385W","NA","S288C YPD + MCHM/ S288C YPD","Up",3.037,0.0108,"NA"]
["S000002195","BSC1","YDL037C","S288C YPD + MCHM/ S288C YPD","Down",-1.911,0.0121,"Protein of unconfirmed function; similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression"]
["S000003125","ARI1","YGL157W","S288C YPD + MCHM/ S288C YPD","Up",1.743,0.0133,"NADPH-dependent aldehyde reductase; utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily"]
["S000005518","ENB1","YOL158C","S288C YPD + MCHM/ S288C YPD","Up",1.71,0.0133,"Endosomal ferric enterobactin transporter; expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment"]
["S000003477","SDA1","YGR245C","S288C YPD + MCHM/ S288C YPD","Down",-1.718,0.0133,"Protein required for actin organization and passage through Start; highly conserved nuclear protein; required for actin cytoskeleton organization; plays a critical role in G1 events; binds Nap1p; involved in 60S ribosome biogenesis"]
["S000000239","PDX3","YBR035C","S288C YPD + MCHM/ S288C YPD","Up",1.728,0.0145,"Pyridoxine (pyridoxamine) phosphate oxidase; has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism"]
["S000004017","AAT2","YLR027C","S288C YPD + MCHM/ S288C YPD","Up",1.458,0.0157,"Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells"]
["S000003596","BNA3","YJL060W","S288C YPD + MCHM/ S288C YPD","Up",1.905,0.0157,"Kynurenine aminotransferase; catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate"]
["S000001356","LYS12","YIL094C","S288C YPD + MCHM/ S288C YPD","Up",1.826,0.0157,"Homo-isocitrate dehydrogenase; an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate"]
["S000002212","MCH1","YDL054C","S288C YPD + MCHM/ S288C YPD","Up",1.625,0.0179,"Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport"]
["NA","YBR056W-A","NA","S288C YPD + MCHM/ S288C YPD","Up",2.796,0.021,"NA"]
["S000004879","RSN1","YMR266W","S288C YPD + MCHM/ S288C YPD","Down",-1.537,0.0231,"Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane"]
["S000002773","ESF1","YDR365C","S288C YPD + MCHM/ S288C YPD","Down",-1.571,0.0241,"Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels"]
["S000000101","PDR3","YBL005W","S288C YPD + MCHM/ S288C YPD","Up",2.031,0.0241,"Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting PDRE sites (PDR responsive elements); has a role in response to drugs and organic solvents; post-translationally up-regulated in cells lacking functional mitochondrial genome; involved in diauxic shift; relative distribution to nucleus increases upon DNA replication stress; APCC(Cdh1) substrate"]
["S000000198","SFT2","YBL102W","S288C YPD + MCHM/ S288C YPD","Up",1.546,0.0241,"Tetra-spanning membrane protein found mostly in the late Golgi; non-essential; can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5"]
["S000002622","AHA1","YDR214W","S288C YPD + MCHM/ S288C YPD","Up",1.568,0.025,"Co-chaperone that binds Hsp82p and activates its ATPase activity; plays a role in determining prion variants; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress"]
["S000001603","OAC1","YKL120W","S288C YPD + MCHM/ S288C YPD","Up",1.908,0.026,"Mitochondrial inner membrane transporter; transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family"]
["S000004702","SNZ1","YMR096W","S288C YPD + MCHM/ S288C YPD","Up",5.915,0.026,"Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins"]
["S000003436","ADE3","YGR204W","S288C YPD + MCHM/ S288C YPD","Up",1.4,0.0269,"Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase; involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine"]
["S000002900","IZH1","YDR492W","S288C YPD + MCHM/ S288C YPD","Down",-1.724,0.0269,"Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication"]
["S000003335","NOP7","YGR103W","S288C YPD + MCHM/ S288C YPD","Down",-1.479,0.0269,"Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation"]
["S000004608","PLB2","YMR006C","S288C YPD + MCHM/ S288C YPD","Down",-1.582,0.0269,"Phospholipase B (lysophospholipase) involved in lipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine"]
["S000000649","THR4","YCR053W","S288C YPD + MCHM/ S288C YPD","Up",1.416,0.0269,"Threonine synthase; conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway"]
["S000003466","YHB1","YGR234W","S288C YPD + MCHM/ S288C YPD","Down",-1.524,0.0269,"Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress"]
["S000005553","STI1","YOR027W","S288C YPD + MCHM/ S288C YPD","Up",1.395,0.0286,"Hsp90 cochaperone; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop"]
["S000005964","NOP4","YPL043W","S288C YPD + MCHM/ S288C YPD","Down",-1.728,0.0295,"Nucleolar protein; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)"]
["NA","YCR061W","NA","S288C YPD + MCHM/ S288C YPD","Up",2.404,0.0303,"NA"]
["S000006316","MRD1","YPR112C","S288C YPD + MCHM/ S288C YPD","Down",-1.8,0.0311,"Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region"]
["S000000813","TIR1","YER011W","S288C YPD + MCHM/ S288C YPD","Down",-2.175,0.0311,"Cell wall mannoprotein; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking; member of the Srp1p/Tip1p family of serine-alanine-rich proteins"]
["S000000247","QDR3","YBR043C","S288C YPD + MCHM/ S288C YPD","Up",1.504,0.0335,"Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; involved in spore wall asembly; sequence similarity to DTR1 and QDR1, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin"]
["S000003393","RTS3","YGR161C","S288C YPD + MCHM/ S288C YPD","Up",1.884,0.0343,"Putative component of the protein phosphatase type 2A complex"]
["NA","YJR111C","NA","S288C YPD + MCHM/ S288C YPD","Up",2.17,0.0352,"NA"]
["S000003666","URA2","YJL130C","S288C YPD + MCHM/ S288C YPD","Up",1.359,0.0376,"Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP"]
["S000000209","RCR1","YBR005W","S288C YPD + MCHM/ S288C YPD","Up",1.642,0.0383,"Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication"]
["S000002189","DBP10","YDL031W","S288C YPD + MCHM/ S288C YPD","Down",-1.479,0.0389,"Putative ATP-dependent RNA helicase of the DEAD-box protein family; constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis"]
["S000001484","MET14","YKL001C","S288C YPD + MCHM/ S288C YPD","Up",2.749,0.0396,"Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism"]
["S000004610","PLB1","YMR008C","S288C YPD + MCHM/ S288C YPD","Up",1.496,0.0411,"Phospholipase B (lysophospholipase) involved in lipid metabolism; required for efficient acyl chain remodeling of newly synthesized phosphatidylethanolamine-derived phosphatidylcholine; required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol; PLB1 has a paralog, PLB3, that arose from the whole genome duplication"]
["S000006195","SAM3","YPL274W","S288C YPD + MCHM/ S288C YPD","Down",-1.694,0.0418,"High-affinity S-adenosylmethionine permease; required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p"]
["S000000530","AGP1","YCL025C","S288C YPD + MCHM/ S288C YPD","Up",1.595,0.0425,"Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication"]
["S000002442","ARO3","YDR035W","S288C YPD + MCHM/ S288C YPD","Up",1.391,0.0438,"3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan"]
["S000002707","BFR2","YDR299W","S288C YPD + MCHM/ S288C YPD","Down",-1.533,0.0445,"Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock"]
["S000005748","ODC2","YOR222W","S288C YPD + MCHM/ S288C YPD","Up",1.59,0.046,"Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism; ODC2 has a paralog, ODC1, that arose from the whole genome duplication"]
["S000001721","PRY2","YKR013W","S288C YPD + MCHM/ S288C YPD","Down",-1.483,0.046,"Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication"]
["S000004441","FPR4","YLR449W","S288C YPD + MCHM/ S288C YPD","Down",-1.478,0.0466,"Peptidyl-prolyl cis-trans isomerase (PPIase); nuclear proline isomerase; affects expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; FPR4 has a paralog, FPR3, that arose from the whole genome duplication"]
["S000003771","MET3","YJR010W","S288C YPD + MCHM/ S288C YPD","Up",1.8,0.0466,"ATP sulfurylase; catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism"]
["S000003310","PAC10","YGR078C","S288C YPD + MCHM/ S288C YPD","Down",-1.955,0.0466,"Part of the heteromeric co-chaperone GimC/prefoldin complex; complex promotes efficient protein folding"]
["S000005420","GPD2","YOL059W","S288C YPD + MCHM/ S288C YPD","Up",1.316,0.0472,"NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1; GPD2 has a paralog, GPD1, that arose from the whole genome duplication"]
["S000005874","PYK2","YOR347C","S288C YPD + MCHM/ S288C YPD","Up",1.896,0.0486,"Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication"]
["S000001094","CIC1","YHR052W","S288C YPD + MCHM/ S288C YPD","Down",-1.599,0.0492,"Essential protein that interacts with proteasome components; has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles"]
["S000002494","RRP1","YDR087C","S288C YPD + MCHM/ S288C YPD","Down",-1.629,0.0498,"Essential evolutionarily conserved nucleolar protein; necessary for biogenesis of 60S ribosomal subunits and for processing of pre-rRNAs to mature rRNA; associated with several distinct 66S pre-ribosomal particles"]