geneID geneLength 293T_Control-Expression 293T_CA04-Expression 293T_Control-RPKM 293T_CA04-RPKM log2 Ratio(293T_CA04/293T_Control) Up-Down-Regulation(293T_CA04/293T_Control) P-value FDR Symbol Description GO Component GO Function GO Process Blast nr 112744 808 0 168 0.001 3.058077034 11.57840903 Up 6.98E-38 6.91E-37 IL17F 3 GO:0044421//extracellular region part GO:0005102//receptor binding;GO:0042802//identical protein binding GO:0001525//angiogenesis;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0006952//defense response;GO:0007179//transforming growth factor beta receptor signaling pathway;GO:0009100//glycoprotein metabolic process;GO:0009888//tissue development;GO:0032641;GO:0032645;GO:0032663;GO:0032675//regulation of interleukin-6 production;GO:0032677 gi|47123369|gb|AAH70124.1|/9.28497e-80/Interleukin 17F [Homo sapiens] 57817 430 0 61 0.001 2.086468727 11.02684758 Up 3.63E-14 1.64E-13 HAMP 2 GO:0044448//cell cortex part GO:0005102//receptor binding GO:0001906//cell killing;GO:0002376//immune system process;GO:0006875//cellular metal ion homeostasis;GO:0006952//defense response gi|10863973|ref|NP_066998.1|/3.81038e-41/hepcidin preproprotein [Homo sapiens] 3453 876 0 106 0.001 1.77972237 10.79743649 Up 3.85E-24 2.59E-23 IFNA22P 1 GO:0044421//extracellular region part GO:0005102//receptor binding GO:0001959//regulation of cytokine-mediated signaling pathway;GO:0006950//response to stress;GO:0007599//hemostasis;GO:0051707//response to other organism gi|296236871|ref|XP_002763517.1|/4.67881e-68/PREDICTED: interferon alpha-5-like [Callithrix jacchus] 100130301 563 0 67 0.001 1.750317795 10.77340117 Up 1.70E-15 8.16E-15 LOC100130301 1 - - - gi|342672089|ref|NP_001230166.1|/3.39393e-77/uncharacterized protein LOC100130301 [Homo sapiens] 2165 2217 0 260 0.001 1.724877095 10.75227785 Up 2.84E-58 4.24E-57 F13B 2 - - GO:0007599//hemostasis gi|110611237|ref|NP_001985.2|/0/coagulation factor XIII B chain precursor [Homo sapiens] 83401 1347 0 142 0.001 1.550498138 10.59851608 Up 4.04E-32 3.44E-31 ELOVL3 1 GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle GO:0004312//fatty acid synthase activity;GO:0005488//binding "GO:0006641//triglyceride metabolic process;GO:0019368//fatty acid elongation, unsaturated fatty acid;GO:0035336//long-chain fatty-acyl-CoA metabolic process" gi|23097310|ref|NP_689523.1|/2.88672e-158/elongation of very long chain fatty acids protein 3 [Homo sapiens] 3442 700 0 72 0.001 1.512811986 10.56301698 Up 1.32E-16 6.69E-16 IFNA5 2 GO:0044421//extracellular region part GO:0005102//receptor binding GO:0001959//regulation of cytokine-mediated signaling pathway;GO:0006950//response to stress;GO:0007599//hemostasis;GO:0051707//response to other organism gi|4504597|ref|NP_002160.1|/1.86361e-104/interferon alpha-5 precursor [Homo sapiens] 5673 1601 0 131 0.001 1.154424298 10.17295786 Up 1.11E-29 8.87E-29 PSG5 1 - - GO:0022414//reproductive process;GO:0048870//cell motility gi|194097367|ref|NP_002772.3|/0/pregnancy-specific beta-1-glycoprotein 5 precursor [Homo sapiens] 56914 1477 0 110 0.001 1.095374661 10.0972087 Up 5.00E-25 3.47E-24 OTOR 2 GO:0043231//intracellular membrane-bounded organelle - GO:0016337//cell-cell adhesion;GO:0050954//sensory perception of mechanical stimulus gi|9910470|ref|NP_064542.1|/6.31108e-69/otoraplin precursor [Homo sapiens] 388701 387 0 28 0.001 1.064137056 10.05546826 Up 7.47E-07 2.16E-06 C1orf189 1 - - - gi|58293781|ref|NP_001010979.1|/2.10772e-52/uncharacterized protein C1orf189 [Homo sapiens] 128876 3166 0 221 0.001 1.026672344 10.00376011 Up 1.25E-49 1.58E-48 FAM83C 5 - - - gi|30425394|ref|NP_848563.1|/0/protein FAM83C [Homo sapiens] 440567 538 0 31 0.001 0.847480899 9.727037042 Up 1.62E-07 4.93E-07 UQCRHL 1 GO:0005746//mitochondrial respiratory chain GO:0005515//protein binding;GO:0015078//hydrogen ion transmembrane transporter activity GO:0022904//respiratory electron transport chain;GO:0051234//establishment of localization;GO:0051259//protein oligomerization gi|148229491|ref|NP_001083060.1|/4.48448e-41/ubiquinol-cytochrome c reductase hinge protein-like [Homo sapiens] 378807 1419 0 80 0.001 0.829197706 9.695572315 Up 2.23E-18 1.21E-17 CATSPER4 1 GO:0019861//flagellum;GO:0030141//secretory granule;GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane GO:0005261//cation channel activity;GO:0005488//binding GO:0030001//metal ion transport;GO:0034220//ion transmembrane transport;GO:0048232//male gamete generation;GO:0048869//cellular developmental process;GO:0048870//cell motility gi|62988334|ref|NP_937770.1|/0/cation channel sperm-associated protein 4 [Homo sapiens] 400823 1345 0 64 0.001 0.699855194 9.450912636 Up 7.84E-15 3.66E-14 FAM177B 2 - - - gi|125346184|ref|NP_997351.2|/4.70178e-76/protein FAM177B [Homo sapiens] 80740 932 0 44 0.001 0.694364109 9.439548568 Up 2.12E-10 7.83E-10 LY6G6C 2 GO:0031224//intrinsic to membrane - - gi|13376874|ref|NP_079537.1|/6.77242e-59/lymphocyte antigen 6 complex locus protein G6c precursor [Homo sapiens] 63910 2612 0 122 0.001 0.68696903 9.42410125 Up 1.09E-27 8.26E-27 SLC17A9 3 GO:0031224//intrinsic to membrane - GO:0016192//vesicle-mediated transport gi|154350196|ref|NP_071365.3|/0/solute carrier family 17 member 9 [Homo sapiens] 343263 1372 0 63 0.001 0.675362494 9.399518251 Up 1.31E-14 6.02E-14 MYBPHL 1 - - - gi|194018539|ref|NP_001010985.2|/0/myosin-binding protein H-like isoform 1 [Homo sapiens]//gi|388453725|ref|NP_001252542.1|/0/myosin-binding protein H-like isoform 2 [Homo sapiens] 50616 1147 0 50 0.001 0.641146221 9.324509608 Up 9.94E-12 3.97E-11 IL22 4 GO:0044421//extracellular region part GO:0005126//cytokine receptor binding GO:0002526//acute inflammatory response;GO:0007154//cell communication gi|10092625|ref|NP_065386.1|/2.35798e-78/interleukin-22 precursor [Homo sapiens] 3567 816 0 35 0.001 0.63085331 9.301160769 Up 2.10E-08 6.82E-08 IL5 2 GO:0000267//cell fraction;GO:0044421//extracellular region part GO:0005126//cytokine receptor binding GO:0001934//positive regulation of protein phosphorylation;GO:0006952//defense response;GO:0007166//cell surface receptor signaling pathway;GO:0010740//positive regulation of intracellular protein kinase cascade;GO:0030854//positive regulation of granulocyte differentiation;GO:0030888//regulation of B cell proliferation;GO:0031334//positive regulation of protein complex assembly;GO:0043388//positive regulation of DNA binding gi|4504671|ref|NP_000870.1|/5.22899e-62/interleukin-5 precursor [Homo sapiens] 84366 403 0 17 0.001 0.620432266 9.277129906 Up 0.000204884 0.000469528 PRAC 2 GO:0043231//intracellular membrane-bounded organelle - - gi|14150227|ref|NP_115767.1|/4.50556e-26/small nuclear protein PRAC [Homo sapiens] 117289 3363 0 129 0.001 0.564174358 9.139997286 Up 3.07E-29 2.43E-28 TAGAP 1 GO:0044444//cytoplasmic part GO:0008047//enzyme activator activity;GO:0030695//GTPase regulator activity GO:0009966//regulation of signal transduction;GO:0035556//intracellular signal transduction gi|20270373|ref|NP_620165.1|/1.43806e-133/T-cell activation Rho GTPase-activating protein isoform c [Homo sapiens]//gi|21314774|ref|NP_473455.2|/0/T-cell activation Rho GTPase-activating protein isoform b [Homo sapiens] 7124 1686 0 64 0.001 0.558306783 9.124914273 Up 7.84E-15 3.66E-14 TNF 3 GO:0005768//endosome;GO:0009986//cell surface;GO:0016021//integral to membrane;GO:0044421//extracellular region part;GO:0044459//plasma membrane part GO:0019899//enzyme binding;GO:0032813//tumor necrosis factor receptor superfamily binding;GO:0043565//sequence-specific DNA binding GO:0001660//fever generation;GO:0001818//negative regulation of cytokine production;GO:0001819//positive regulation of cytokine production;GO:0001934//positive regulation of protein phosphorylation;GO:0002036//regulation of L-glutamate transport;GO:0002374;GO:0002439//chronic inflammatory response to antigenic stimulus;GO:0002455//humoral immune response mediated by circulating immunoglobulin;GO:0002637//regulation of immunoglobulin production;GO:0002763//positive regulation of myeloid leukocyte differentiation;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0006447//regulation of translational initiation by iron;GO:0006941//striated muscle contraction;GO:0006970//response to osmotic stress;GO:0007088//regulation of mitosis;GO:0007159//leukocyte cell-cell adhesion;GO:0007249//I-kappaB kinase/NF-kappaB cascade;GO:0008284//positive regulation of cell proliferation;GO:0008624;GO:0009605//response to external stimulus;GO:0009895;GO:0010829//negative regulation of glucose transport;GO:0010883//regulation of lipid storage;GO:0010893//positive regulation of steroid biosynthetic process;GO:0019221//cytokine-mediated signaling pathway;GO:0019318//hexose metabolic process;GO:0019932//second-messenger-mediated signaling;GO:0022409//positive regulation of cell-cell adhesion;GO:0030073//insulin secretion;GO:0031331;GO:0031334//positive regulation of protein complex assembly;GO:0031960//response to corticosteroid stimulus;GO:0032770//positive regulation of monooxygenase activity;GO:0042108//positive regulation of cytokine biosynthetic process;GO:0042345//regulation of NF-kappaB import into nucleus;GO:0042742//defense response to bacterium;GO:0042993//positive regulation of transcription factor import into nucleus;GO:0043062//extracellular structure organization;GO:0043066//negative regulation of apoptotic process;GO:0043241//protein complex disassembly;GO:0043405//regulation of MAP kinase activity;GO:0043410//positive regulation of MAPK cascade;GO:0044126;GO:0045069//regulation of viral genome replication;GO:0045596//negative regulation of cell differentiation;GO:0045684//positive regulation of epidermis development;GO:0048565//digestive tract development;GO:0050673//epithelial cell proliferation;GO:0050707//regulation of cytokine secretion;GO:0050804//regulation of synaptic transmission;GO:0050900//leukocyte migration;GO:0051091//positive regulation of sequence-specific DNA binding transcription factor activity;GO:0060553;GO:0060688//regulation of morphogenesis of a branching structure gi|25952111|ref|NP_000585.2|/6.9161e-123/tumor necrosis factor [Homo sapiens] 401250 709 0 26 0.001 0.539358606 9.075100995 Up 2.07E-06 5.78E-06 MCCD1 2 - - - gi|155969718|ref|NP_001011700.2|/4.75339e-47/mitochondrial coiled-coil domain protein 1 precursor [Homo sapiens] 643037 604 0 22 0.001 0.535718005 9.065329973 Up 1.60E-05 4.10E-05 LOC643037 1 - - - gi|299473756|ref|NP_001177391.1|/4.67885e-65/uncharacterized protein LOC643037 [Homo sapiens] 4225 2327 0 83 0.001 0.524604739 9.03508703 Up 4.82E-19 2.69E-18 MEP1B 2 GO:0005626//insoluble fraction;GO:0016021//integral to membrane;GO:0044421//extracellular region part GO:0004175//endopeptidase activity;GO:0046914//transition metal ion binding GO:0019538//protein metabolic process;GO:0032501//multicellular organismal process gi|153070264|ref|NP_005916.2|/0/meprin A subunit beta precursor [Homo sapiens] 162605 1692 0 60 0.001 0.521556536 9.026679836 Up 6.04E-14 2.70E-13 KRT28 3 GO:0043234//protein complex;GO:0044424//intracellular part - - gi|34526448|dbj|BAC85240.1|/0/unnamed protein product [Homo sapiens] 387804 603 0 21 0.001 0.512215225 9.000606325 Up 2.66E-05 6.71E-05 VSTM5 1 GO:0031224//intrinsic to membrane - - gi|221554524|ref|NP_001138343.1|/2.91033e-91/V-set and transmembrane domain-containing protein 5 precursor [Homo sapiens] 339240 3153 0 103 0.001 0.48046721 8.908294166 Up 1.78E-23 1.17E-22 LOC339240 1 GO:0043234//protein complex;GO:0044424//intracellular part - - gi|34535120|dbj|BAC87214.1|/1.79798e-80/unnamed protein product [Homo sapiens] 441869 2205 0 72 0.001 0.480257773 8.907665155 Up 1.32E-16 6.69E-16 ANKRD65 1 - - - gi|223634006|ref|NP_001138682.1|/1.23787e-69/ankyrin repeat domain-containing protein 65 isoform 1 [Homo sapiens]//gi|343780881|ref|NP_001230464.1|/2.0623e-95/ankyrin repeat domain-containing protein 65 isoform 2 [Homo sapiens]//gi|343780881|ref|NP_001230464.1|/5.24422e-86/ankyrin repeat domain-containing protein 65 isoform 2 [Homo sapiens] 143941 679 0 22 0.001 0.47654444 8.896466948 Up 1.60E-05 4.10E-05 TTC36 1 - - - gi|122937279|ref|NP_001073910.1|/1.4338e-82/tetratricopeptide repeat protein 36 [Homo sapiens] 201516 2260 0 73 0.001 0.475078002 8.892020595 Up 7.94E-17 4.06E-16 ZSCAN4 2 "GO:0000781//chromosome, telomeric region;GO:0043231//intracellular membrane-bounded organelle" GO:0001071//nucleic acid binding transcription factor activity;GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding "GO:0000723//telomere maintenance;GO:0006351//transcription, DNA-dependent" gi|22749365|ref|NP_689890.1|/0/zinc finger and SCAN domain-containing protein 4 [Homo sapiens] 113802 1890 0 59 0.001 0.459135325 8.842775624 Up 1.01E-13 4.45E-13 HENMT1 1 GO:0043232 GO:0008168//methyltransferase activity GO:0006730//one-carbon metabolic process;GO:0009451//RNA modification;GO:0034660//ncRNA metabolic process gi|156564365|ref|NP_653185.2|/0/small RNA 2'-O-methyltransferase [Homo sapiens] 51471 845 0 26 0.001 0.452550594 8.821935281 Up 2.07E-06 5.79E-06 NAT8B 2 GO:0031224//intrinsic to membrane GO:0016407//acetyltransferase activity GO:0007369//gastrulation;GO:0042221//response to chemical stimulus gi|117168283|ref|NP_057431.2|/1.53626e-112/probable N-acetyltransferase 8B [Homo sapiens] 29895 683 0 21 0.001 0.452219298 8.820878748 Up 2.66E-05 6.71E-05 MYLPF 3 GO:0016460//myosin II complex;GO:0043292//contractile fiber GO:0003779//actin binding;GO:0005198//structural molecule activity;GO:0017111//nucleoside-triphosphatase activity;GO:0046872//metal ion binding GO:0001708//cell fate specification;GO:0002376//immune system process;GO:0003012//muscle system process;GO:0003015//heart process;GO:0016049//cell growth;GO:0030239//myofibril assembly;GO:0055008//cardiac muscle tissue morphogenesis "gi|28372499|ref|NP_037424.2|/6.92966e-93/myosin regulatory light chain 2, skeletal muscle isoform [Homo sapiens]" 1590 2429 0 73 0.001 0.442023995 8.787980878 Up 7.94E-17 4.06E-16 CYP21A1P 1 GO:0031090//organelle membrane;GO:0042598;GO:0043231//intracellular membrane-bounded organelle GO:0004497//monooxygenase activity;GO:0005506//iron ion binding;GO:0008289//lipid binding GO:0006700//C21-steroid hormone biosynthetic process gi|180962|gb|AAA52063.1|/0/CYP21B protein [Homo sapiens] 59340 3686 0 108 0.001 0.430942101 8.75135024 Up 1.39E-24 9.51E-24 HRH4 1 GO:0005626//insoluble fraction;GO:0016021//integral to membrane;GO:0031224//intrinsic to membrane GO:0008227//G-protein coupled amine receptor activity GO:0006952//defense response;GO:0007166//cell surface receptor signaling pathway gi|14251205|ref|NP_067637.2|/0/histamine H4 receptor isoform 1 [Homo sapiens]//gi|15822541|gb|AAL09297.1|/1.25513e-130/histamine receptor H4 [Homo sapiens]//gi|219842331|ref|NP_001137300.1|/1.4285e-147/histamine H4 receptor isoform 2 [Homo sapiens] 279 1660 0 48 0.001 0.42528851 8.732298068 Up 2.76E-11 1.08E-10 AMY2A 2 GO:0044421//extracellular region part GO:0016160//amylase activity;GO:0043168;GO:0046872//metal ion binding GO:0005975//carbohydrate metabolic process;GO:0007586//digestion gi|4502085|ref|NP_000690.1|/0/pancreatic alpha-amylase precursor [Homo sapiens] 79935 1817 0 52 0.001 0.420919375 8.717400108 Up 3.58E-12 1.46E-11 CNTD2 3 - - - gi|242247025|ref|NP_079153.2|/4.01498e-132/cyclin N-terminal domain-containing protein 2 isoform 2 [Homo sapiens] 55821 1470 0 42 0.001 0.420225552 8.715020077 Up 5.90E-10 2.12E-09 ALLC 3 - "GO:0016813//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines" - gi|327478594|sp|Q8N6M5.3|ALLC_HUMAN/0/RecName: Full=Probable allantoicase; AltName: Full=Allantoate amidinohydrolase 401172 2419 0 67 0.001 0.407370367 8.67019723 Up 1.70E-15 8.16E-15 FLJ33360 1 - - - gi|119628516|gb|EAX08111.1|/1.28095e-91/FLJ33360 protein [Homo sapiens] 6554 1631 0 44 0.001 0.396779491 8.632193646 Up 2.12E-10 7.82E-10 SLC10A1 3 GO:0005626//insoluble fraction;GO:0016021//integral to membrane;GO:0044459//plasma membrane part GO:0005343//organic acid:sodium symporter activity;GO:0008028//monocarboxylic acid transmembrane transporter activity GO:0006820//anion transport;GO:0008202//steroid metabolic process;GO:0015718//monocarboxylic acid transport;GO:0035725//sodium ion transmembrane transport gi|4506971|ref|NP_003040.1|/0/sodium/bile acid cotransporter [Homo sapiens] 55891 671 0 18 0.001 0.39454858 8.624059139 Up 0.000122989 0.000289476 LENEP 2 GO:0044424//intracellular part GO:0003676//nucleic acid binding GO:0032501//multicellular organismal process gi|8923830|ref|NP_061125.1|/8.0055e-30/lens epithelial cell protein LEP503 [Homo sapiens] 100505591 878 0 23 0.001 0.385286525 8.58978792 Up 9.59E-06 2.52E-05 LRRC3C 1 GO:0031224//intrinsic to membrane - - gi|306966160|ref|NP_001182474.1|/1.24741e-152/leucine-rich repeat-containing protein 3C precursor [Homo sapiens] 10637 1644 0 43 0.001 0.384695532 8.587573265 Up 3.54E-10 1.29E-09 LEFTY1 3 GO:0031091//platelet alpha granule;GO:0044421//extracellular region part GO:0005126//cytokine receptor binding GO:0001775//cell activation;GO:0006887//exocytosis;GO:0007178//transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007599//hemostasis;GO:0040007//growth gi|10337603|ref|NP_066277.1|/0/left-right determination factor 1 preproprotein [Homo sapiens] 390245 2339 0 61 0.001 0.383574841 8.583364285 Up 3.63E-14 1.64E-13 KDM4E 1 GO:0043231//intracellular membrane-bounded organelle "GO:0016701//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0043169//cation binding" GO:0006325//chromatin organization;GO:0008152//metabolic process gi|256017129|ref|NP_001155102.1|/0/lysine-specific demethylase 4E [Homo sapiens] 72 1345 0 35 0.001 0.382733309 8.580195653 Up 2.10E-08 6.83E-08 ACTG2 1 GO:0032432//actin filament bundle;GO:0043232;GO:0043292//contractile fiber;GO:0044444//cytoplasmic part GO:0005198//structural molecule activity;GO:0032559 GO:0003012//muscle system process;GO:0006939//smooth muscle contraction;GO:0007015//actin filament organization;GO:0008015//blood circulation;GO:0048747//muscle fiber development;GO:0051707//response to other organism "gi|315570273|ref|NP_001186822.1|/0/actin, gamma-enteric smooth muscle isoform 2 precursor [Homo sapiens] //gi|344253851|gb|EGW09955.1|/0/Actin, gamma-enteric smooth muscle [Cricetulus griseus]" 2069 4628 0 119 0.001 0.378184836 8.562947708 Up 5.06E-27 3.75E-26 EREG 2 GO:0016021//integral to membrane;GO:0044421//extracellular region part GO:0070851//growth factor receptor binding "GO:0001547//antral ovarian follicle growth;GO:0006275//regulation of DNA replication;GO:0006351//transcription, DNA-dependent;GO:0007088//regulation of mitosis;GO:0007126//meiosis;GO:0007154//cell communication;GO:0007176//regulation of epidermal growth factor-activated receptor activity;GO:0007186//G-protein coupled receptor signaling pathway;GO:0008284//positive regulation of cell proliferation;GO:0008285//negative regulation of cell proliferation;GO:0009611//response to wounding;GO:0009725//response to hormone stimulus;GO:0009913//epidermal cell differentiation;GO:0022605//oogenesis stage;GO:0031349//positive regulation of defense response;GO:0033674//positive regulation of kinase activity;GO:0042108//positive regulation of cytokine biosynthetic process;GO:0045765//regulation of angiogenesis;GO:0051148//negative regulation of muscle cell differentiation" gi|4557567|ref|NP_001423.1|/3.6882e-85/proepiregulin preproprotein [Homo sapiens] 5017 3039 0 77 0.001 0.372658066 8.541708675 Up 1.03E-17 5.47E-17 OVOL1 3 GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0007128//meiotic prophase I;GO:0009888//tissue development;GO:0048232//male gamete generation gi|37590309|gb|AAH59408.1|/2.19838e-160/Ovo-like 1(Drosophila) [Homo sapiens] 92483 1773 0 44 0.001 0.365001325 8.511757892 Up 2.12E-10 7.82E-10 LDHAL6B 2 GO:0043231//intracellular membrane-bounded organelle GO:0004457//lactate dehydrogenase activity;GO:0005488//binding GO:0006007//glucose catabolic process gi|15082234|ref|NP_149972.1|/0/L-lactate dehydrogenase A-like 6B [Homo sapiens] 696 2859 0 69 0.001 0.35496492 8.471532646 Up 6.11E-16 3.01E-15 BTN1A1 2 GO:0016021//integral to membrane GO:0004871//signal transducer activity - gi|166197658|ref|NP_001723.2|/0/butyrophilin subfamily 1 member A1 precursor [Homo sapiens] 55507 1038 0 25 0.001 0.354236375 8.468568555 Up 3.45E-06 9.47E-06 GPRC5D 1 GO:0031224//intrinsic to membrane GO:0004888//transmembrane signaling receptor activity GO:0007165//signal transduction;GO:0030216//keratinocyte differentiation;GO:0042303//molting cycle gi|8923705|ref|NP_061124.1|/2.7777e-168/G-protein coupled receptor family C group 5 member D [Homo sapiens] 3211 1014 0 23 0.001 0.333611015 8.382023113 Up 9.59E-06 2.51E-05 HOXB1 3 GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0003677//DNA binding;GO:0005515//protein binding GO:0003002//regionalization;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0021546//rhombomere development;GO:0021548//pons development;GO:0021604;GO:0048562//embryonic organ morphogenesis gi|24497526|ref|NP_002135.2|/1.06126e-132/homeobox protein Hox-B1 [Homo sapiens] 1117 1516 0 34 0.001 0.329860426 8.365711897 Up 3.50E-08 1.12E-07 CHI3L2 1 GO:0044421//extracellular region part "GO:0004553//hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0043167//ion binding" GO:0006026 "gi|119576884|gb|EAW56480.1|/0/chitinase 3-like 2, isoform CRA_a [Homo sapiens]//gi|1439568|gb|AAB04534.1|/0/chitinase, partial [Homo sapiens]" 285972 2043 0 44 0.001 0.316763265 8.307261224 Up 2.12E-10 7.82E-10 LOC285972 1 - - - gi|119574494|gb|EAW54109.1|/1.02053e-62/hCG2038204 [Homo sapiens] 8600 2377 0 51 0.001 0.315566937 8.301802248 Up 5.97E-12 2.40E-11 TNFSF11 3 GO:0016021//integral to membrane;GO:0044421//extracellular region part;GO:0044424//intracellular part GO:0004871//signal transducer activity;GO:0032813//tumor necrosis factor receptor superfamily binding GO:0002763//positive regulation of myeloid leukocyte differentiation;GO:0019221//cytokine-mediated signaling pathway;GO:0022409//positive regulation of cell-cell adhesion;GO:0030595//leukocyte chemotaxis;GO:0031622//positive regulation of fever generation;GO:0046887//positive regulation of hormone secretion;GO:0050863//regulation of T cell activation;GO:0051091//positive regulation of sequence-specific DNA binding transcription factor activity;GO:0070374//positive regulation of ERK1 and ERK2 cascade gi|16610213|dbj|BAB71768.1|/1.11854e-140/hRANKL 2 [Homo sapiens]//gi|4507595|ref|NP_003692.1|/1.29572e-159/tumor necrosis factor ligand superfamily member 11 isoform 1 [Homo sapiens] 646862 990 0 21 0.001 0.311985637 8.285335802 Up 2.66E-05 6.71E-05 LOC646862 1 - - - gi|304376280|ref|NP_001182064.1|/1.88065e-94/uncharacterized protein LOC646862 [Homo sapiens] 155038 3952 0 83 0.001 0.308895553 8.270975294 Up 4.82E-19 2.69E-18 GIMAP8 2 GO:0043231//intracellular membrane-bounded organelle GO:0000166//nucleotide binding - gi|28416956|ref|NP_783161.1|/0/GTPase IMAP family member 8 [Homo sapiens] 340543 1166 0 24 0.001 0.302735389 8.241913521 Up 5.75E-06 1.54E-05 TCEAL5 2 GO:0043231//intracellular membrane-bounded organelle GO:0005488//binding - gi|61175239|ref|NP_001012997.1|/2.10438e-106/transcription elongation factor A protein-like 5 [Homo sapiens] 3448 778 0 16 0.001 0.302475975 8.240676749 Up 0.000341308 0.000761201 IFNA14 2 GO:0044421//extracellular region part GO:0005102//receptor binding GO:0001959//regulation of cytokine-mediated signaling pathway;GO:0006950//response to stress;GO:0007599//hemostasis;GO:0051707//response to other organism gi|170763491|ref|NP_002163.2|/5.04005e-88/interferon alpha-14 precursor [Homo sapiens] 387695 835 0 17 0.001 0.29944216 8.226133548 Up 0.000204884 0.000469471 C10orf99 2 - - - "gi|119600771|gb|EAW80365.1|/6.37149e-63/chromosome 10 open reading frame 99, isoform CRA_a [Homo sapiens]" 2160 3278 0 66 0.001 0.2961321 8.210097074 Up 2.83E-15 1.35E-14 F11 3 GO:0016020//membrane;GO:0044421//extracellular region part GO:0004175//endopeptidase activity;GO:0004177//aminopeptidase activity;GO:0005539//glycosaminoglycan binding GO:0030195//negative regulation of blood coagulation;GO:0031638//zymogen activation;GO:0072376 gi|4503627|ref|NP_000119.1|/0/coagulation factor XI precursor [Homo sapiens] 219770 1580 0 31 0.001 0.28857261 8.172790561 Up 1.62E-07 4.93E-07 GJD4 2 GO:0030054//cell junction - - gi|145699105|ref|NP_699199.2|/7.98376e-158/gap junction delta-4 protein [Homo sapiens] 2984 3850 0 74 0.001 0.282697189 8.143113729 Up 4.76E-17 2.46E-16 GUCY2C 3 GO:0031224//intrinsic to membrane GO:0004871//signal transducer activity;GO:0009975//cyclase activity;GO:0016301//kinase activity;GO:0016829//lyase activity;GO:0032559;GO:0032561//guanyl ribonucleotide binding GO:0006164//purine nucleotide biosynthetic process;GO:0006464//cellular protein modification process;GO:0007167//enzyme linked receptor protein signaling pathway;GO:0008283//cell proliferation;GO:0009124//nucleoside monophosphate biosynthetic process;GO:0042221//response to chemical stimulus gi|222080083|ref|NP_004954.2|/0/heat-stable enterotoxin receptor precursor [Homo sapiens] 57467 1875 0 36 0.001 0.282391571 8.141553215 Up 1.26E-08 4.16E-08 HHATL 3 GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part "GO:0005488//binding;GO:0016747//transferase activity, transferring acyl groups other than amino-acyl groups" GO:0010558 gi|239582769|ref|NP_065758.3|/0/protein-cysteine N-palmitoyltransferase HHAT-like protein [Homo sapiens] 9576 2989 0 57 0.001 0.280478413 8.131745926 Up 2.79E-13 1.21E-12 SPAG6 1 GO:0015630//microtubule cytoskeleton;GO:0042995//cell projection;GO:0043231//intracellular membrane-bounded organelle - GO:0007281//germ cell development;GO:0048232//male gamete generation;GO:0048870//cell motility;GO:0071842 gi|27262641|ref|NP_758442.1|/0/sperm-associated antigen 6 isoform 2 [Homo sapiens]//gi|359718953|ref|NP_001240783.1|/0/sperm-associated antigen 6 isoform 3 [Homo sapiens] //gi|6912678|ref|NP_036575.1|/0/sperm-associated antigen 6 isoform 1 [Homo sapiens] 4066 1788 0 34 0.001 0.279680317 8.127634914 Up 3.50E-08 1.12E-07 LYL1 4 - GO:0003676//nucleic acid binding GO:0001568//blood vessel development;GO:0030098//lymphocyte differentiation "gi|1196440|gb|AAA88084.1|/2.91699e-151/unknown protein, partial [Homo sapiens]" 389396 2130 0 40 0.001 0.276204588 8.109593474 Up 1.64E-09 5.73E-09 GLYATL3 1 GO:0043231//intracellular membrane-bounded organelle GO:0016410//N-acyltransferase activity - gi|222831633|ref|NP_001010904.1|/1.50374e-165/glycine N-acyltransferase-like protein 3 [Homo sapiens] 51442 1242 0 23 0.001 0.272368413 8.089415592 Up 9.59E-06 2.52E-05 VGLL1 3 GO:0043231//intracellular membrane-bounded organelle GO:0003712//transcription cofactor activity "GO:0006351//transcription, DNA-dependent" gi|7706741|ref|NP_057351.1|/1.37255e-151/transcription cofactor vestigial-like protein 1 [Homo sapiens] 10578 995 0 18 0.001 0.26607246 8.05567538 Up 0.000122989 0.000289548 GNLY 3 GO:0044421//extracellular region part - GO:0001906//cell killing;GO:0006952//defense response gi|194388214|dbj|BAG65491.1|/4.98563e-87/unnamed protein product [Homo sapiens]//gi|7108344|ref|NP_006424.2|/1.38682e-71/granulysin isoform NKG5 precursor [Homo sapiens] 259197 1109 0 20 0.001 0.265246065 8.051187538 Up 4.43E-05 0.000109535 NCR3 1 GO:0016021//integral to membrane GO:0004871//signal transducer activity GO:0001912//positive regulation of leukocyte mediated cytotoxicity;GO:0006952//defense response;GO:0009987//cellular process gi|224586860|ref|NP_001138938.1|/2.09534e-84/natural cytotoxicity triggering receptor 3 isoform b precursor [Homo sapiens]//gi|224586865|ref|NP_001138939.1|/3.66605e-96/natural cytotoxicity triggering receptor 3 isoform c precursor [Homo sapiens]//gi|24475832|ref|NP_667341.1|/3.21661e-87/natural cytotoxicity triggering receptor 3 isoform a precursor [Homo sapiens] 284835 2019 0 36 0.001 0.262250716 8.0348029 Up 1.26E-08 4.16E-08 LINC00323 1 - - - gi|119630022|gb|EAX09617.1|/3.49274e-39/hCG2007462 [Homo sapiens] 124783 1297 0 23 0.001 0.26081848 8.026902286 Up 9.59E-06 2.52E-05 TEX34 2 - - - gi|149408117|ref|NP_689556.2|/0/testis-expressed sequence 34 protein [Homo sapiens] 3846 1188 0 21 0.001 0.259988031 8.022301396 Up 2.66E-05 6.71E-05 KRTAP5-9 3 - - - gi|16549806|dbj|BAB70862.1|/2.05106e-32/unnamed protein product [Homo sapiens] 6295 1767 0 31 0.001 0.258033233 8.01141308 Up 1.62E-07 4.93E-07 SAG 4 - GO:0005515//protein binding;GO:0019212//phosphatase inhibitor activity "GO:0007186//G-protein coupled receptor signaling pathway;GO:0007603//phototransduction, visible light;GO:0050953//sensory perception of light stimulus" gi|116008178|ref|NP_000532.2|/0/S-arrestin [Homo sapiens] 342574 1612 0 28 0.001 0.25547211 7.997021987 Up 7.47E-07 2.16E-06 KRT27 3 GO:0043234//protein complex;GO:0044424//intracellular part - GO:0001942//hair follicle development "gi|153945736|ref|NP_853515.2|/0/keratin, type I cytoskeletal 27 [Homo sapiens]" 6121 2608 0 45 0.001 0.253778851 7.987428036 Up 1.28E-10 4.76E-10 RPE65 2 GO:0016020//membrane;GO:0044424//intracellular part GO:0004091//carboxylesterase activity;GO:0016859//cis-trans isomerase activity;GO:0043169//cation binding GO:0001523//retinoid metabolic process;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0009653//anatomical structure morphogenesis;GO:0010468//regulation of gene expression;GO:0050953//sensory perception of light stimulus;GO:0051602//response to electrical stimulus gi|4506591|ref|NP_000320.1|/0/retinoid isomerohydrolase [Homo sapiens] 57830 1198 0 20 0.001 0.245540806 7.939818996 Up 4.43E-05 0.000109506 KRTAP5-8 2 - - - gi|297267212|ref|XP_002799497.1|/8.4229e-34/PREDICTED: hypothetical protein LOC100426812 [Macaca mulatta] 390594 3123 0 52 0.001 0.244896095 7.936025958 Up 3.58E-12 1.46E-11 KBTBD13 2 GO:0044424//intracellular part - - gi|157384932|ref|NP_001094832.1|/0/kelch repeat and BTB domain-containing protein 13 [Homo sapiens] 339403 1146 0 19 0.001 0.24384816 7.929839278 Up 7.38E-05 0.000178329 RXFP4 2 GO:0031224//intrinsic to membrane GO:0001595//angiotensin receptor activity - gi|32490567|ref|NP_871001.1|/0/relaxin-3 receptor 2 [Homo sapiens] 316 4949 0 82 0.001 0.243695157 7.928933772 Up 8.03E-19 4.46E-18 AOX1 3 GO:0044424//intracellular part "GO:0000166//nucleotide binding;GO:0016623;GO:0016726//oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor;GO:0046914//transition metal ion binding;GO:0050662//coenzyme binding;GO:0051536//iron-sulfur cluster binding" GO:0006952//defense response;GO:0008152//metabolic process gi|71773480|ref|NP_001150.3|/0/aldehyde oxidase [Homo sapiens] 148870 2174 0 36 0.001 0.243552988 7.92809187 Up 1.26E-08 4.16E-08 CCDC27 2 - - - gi|217035164|ref|NP_689705.2|/0/coiled-coil domain-containing protein 27 [Homo sapiens] 26287 1462 0 24 0.001 0.241442861 7.915537999 Up 5.75E-06 1.54E-05 ANKRD2 2 GO:0030017//sarcomere GO:0005198//structural molecule activity GO:0003012//muscle system process;GO:0048513//organ development gi|34915797|emb|CAE47432.1|/0/ankyrin repeat protein [Homo sapiens] 55889 3178 0 52 0.001 0.240657805 7.910839403 Up 3.58E-12 1.46E-11 GOLGA6B 4 - - - gi|94538359|ref|NP_061122.4|/0/putative golgin subfamily A member 6B [Homo sapiens] 646799 1103 0 18 0.001 0.240020034 7.90701102 Up 0.000122989 0.000289262 ZAR1L 1 GO:0044464//cell part GO:0005343//organic acid:sodium symporter activity GO:0030001//metal ion transport gi|211971095|ref|NP_001130043.1|/0/ZAR1-like protein [Homo sapiens] 100505576 3708 0 60 0.001 0.237991817 7.894768161 Up 6.04E-14 2.70E-13 LOC100505576 1 - - - gi|119601568|gb|EAW81162.1|/3.85941e-29/hCG1814203 [Homo sapiens] 388581 1052 0 17 0.001 0.237675098 7.892846946 Up 0.000204884 0.00046981 FAM132A 2 - - - gi|121949746|ref|NP_001014980.1|/1.32359e-141/protein FAM132A precursor [Homo sapiens] 9982 1369 0 22 0.001 0.236357688 7.884827981 Up 1.60E-05 4.10E-05 FGFBP1 4 GO:0016020//membrane;GO:0044421//extracellular region part GO:0005539//glycosaminoglycan binding;GO:0019838//growth factor binding GO:0008283//cell proliferation;GO:0009967//positive regulation of signal transduction gi|4826754|ref|NP_005121.1|/1.29915e-121/fibroblast growth factor-binding protein 1 precursor [Homo sapiens] 27035 2529 0 39 0.001 0.22681213 7.825353991 Up 2.73E-09 9.41E-09 NOX1 4 GO:0005768//endosome;GO:0005887//integral to plasma membrane;GO:0031253//cell projection membrane "GO:0000166//nucleotide binding;GO:0015252//hydrogen ion channel activity;GO:0017048//Rho GTPase binding;GO:0046914//transition metal ion binding;GO:0050662//coenzyme binding;GO:0050664//oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor" GO:0001819//positive regulation of cytokine production;GO:0001990;GO:0006091//generation of precursor metabolites and energy;GO:0006801//superoxide metabolic process;GO:0006818//hydrogen transport;GO:0006952//defense response;GO:0008284//positive regulation of cell proliferation;GO:0009628//response to abiotic stimulus;GO:0010557//positive regulation of macromolecule biosynthetic process;GO:0023052//signaling;GO:0043062//extracellular structure organization;GO:0045852;GO:0046496//nicotinamide nucleotide metabolic process;GO:0048646//anatomical structure formation involved in morphogenesis;GO:0048870//cell motility gi|148536873|ref|NP_008983.2|/0/NADPH oxidase 1 isoform long [Homo sapiens]//gi|7669510|ref|NP_039249.1|/0/NADPH oxidase 1 isoform long variant [Homo sapiens] 346171 1870 0 28 0.001 0.220225155 7.782835461 Up 7.47E-07 2.16E-06 ZFP57 2 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding "GO:0006306//DNA methylation;GO:0006351//transcription, DNA-dependent;GO:0032501//multicellular organismal process" gi|239582722|ref|NP_001103279.2|/0/zinc finger protein 57 homolog [Homo sapiens] 139105 4720 0 70 0.001 0.218125551 7.769014966 Up 3.67E-16 1.82E-15 BEND2 1 - - - gi|193794843|ref|NP_699177.2|/0/BEN domain-containing protein 2 isoform 1 [Homo sapiens]//gi|296179403|ref|NP_001171696.1|/0/BEN domain-containing protein 2 isoform 2 [Homo sapiens] 112714 1554 0 23 0.001 0.217684407 7.766094261 Up 9.59E-06 2.52E-05 TUBA3E 2 GO:0005815//microtubule organizing center;GO:0042995//cell projection GO:0017111//nucleoside-triphosphatase activity;GO:0032561//guanyl ribonucleotide binding GO:0006458//'de novo' protein folding;GO:0007017//microtubule-based process;GO:0043623//cellular protein complex assembly gi|224471855|sp|Q6PEY2.2|TBA3E_HUMAN/0/RecName: Full=Tubulin alpha-3E chain; AltName: Full=Alpha-tubulin 3E 140576 1085 0 16 0.001 0.216890607 7.760823766 Up 0.000341308 0.000761379 S100A16 1 GO:0031981//nuclear lumen;GO:0044444//cytoplasmic part GO:0042802//identical protein binding;GO:0046872//metal ion binding GO:0010038//response to metal ion gi|17933772|ref|NP_525127.1|/7.76409e-52/protein S100-A16 [Homo sapiens] 399 1999 0 29 0.001 0.213371153 7.737221332 Up 4.49E-07 1.32E-06 RHOH 3 GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part;GO:0044459//plasma membrane part GO:0004857//enzyme inhibitor activity;GO:0017016//Ras GTPase binding;GO:0032561//guanyl ribonucleotide binding GO:0002274;GO:0007249//I-kappaB kinase/NF-kappaB cascade;GO:0009966//regulation of signal transduction;GO:0016310//phosphorylation;GO:0019222//regulation of metabolic process;GO:0030098//lymphocyte differentiation gi|4757770|ref|NP_004301.1|/2.87648e-94/rho-related GTP-binding protein RhoH precursor [Homo sapiens] 81492 2484 0 36 0.001 0.213157888 7.735778637 Up 1.26E-08 4.16E-08 RSPH6A 3 GO:0044464//cell part - - gi|223459604|gb|AAI36353.1|/0/Radial spokehead-like 1 [Homo sapiens] 135644 1939 0 28 0.001 0.212388365 7.730560928 Up 7.47E-07 2.16E-06 TRIM40 3 GO:0044464//cell part GO:0046914//transition metal ion binding - gi|20162564|ref|NP_619645.1|/1.72544e-112/tripartite motif-containing protein 40 [Homo sapiens] 342372 5199 0 75 0.001 0.212173894 7.729103344 Up 2.86E-17 1.49E-16 PKD1L3 1 GO:0031224//intrinsic to membrane GO:0015075//ion transmembrane transporter activity;GO:0030246//carbohydrate binding GO:0006810//transport;GO:0007186//G-protein coupled receptor signaling pathway gi|31559825|ref|NP_853514.1|/0/polycystic kidney disease protein 1-like 3 precursor [Homo sapiens] 5225 1392 0 20 0.001 0.21132032 7.723287693 Up 4.43E-05 0.000109549 PGC 1 GO:0044421//extracellular region part GO:0004175//endopeptidase activity GO:0019538//protein metabolic process;GO:0032501//multicellular organismal process gi|262206232|ref|NP_001159896.1|/0/gastricsin isoform 2 preproprotein [Homo sapiens] //gi|4505757|ref|NP_002621.1|/0/gastricsin isoform 1 preproprotein [Homo sapiens] 10595 3634 0 52 0.001 0.210459687 7.717400108 Up 3.58E-12 1.46E-11 ERN2 3 GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle GO:0004521//endoribonuclease activity;GO:0004672//protein kinase activity;GO:0032559;GO:0046872//metal ion binding GO:0006396//RNA processing;GO:0006464//cellular protein modification process;GO:0012502//induction of programmed cell death;GO:0016072//rRNA metabolic process;GO:0022402//cell cycle process;GO:0050896//response to stimulus gi|145312265|ref|NP_150296.3|/0/serine/threonine-protein kinase/endoribonuclease IRE2 [Homo sapiens] 419 1563 0 23 0.001 0.209721989 7.712334327 Up 9.59E-06 2.52E-05 ART3 5 GO:0016021//integral to membrane "GO:0016763//transferase activity, transferring pentosyl groups" GO:0006464//cellular protein modification process gi|194097380|ref|NP_001123488.1|/0/ecto-ADP-ribosyltransferase 3 isoform a precursor [Homo sapiens]//gi|194097382|ref|NP_001123489.1|/0/ecto-ADP-ribosyltransferase 3 isoform c precursor [Homo sapiens]//gi|21361167|ref|NP_001170.2|/0/ecto-ADP-ribosyltransferase 3 isoform b precursor [Homo sapiens] 941 2757 0 39 0.001 0.208055088 7.700821761 Up 2.73E-09 9.40E-09 CD80 3 GO:0009986//cell surface;GO:0031224//intrinsic to membrane GO:0004872//receptor activity;GO:0005488//binding GO:0001934//positive regulation of protein phosphorylation;GO:0007154//cell communication;GO:0007165//signal transduction;GO:0031294;GO:0042102//positive regulation of T cell proliferation;GO:0042108//positive regulation of cytokine biosynthetic process;GO:0045624//positive regulation of T-helper cell differentiation;GO:0051704 gi|4885123|ref|NP_005182.1|/5.93371e-157/T-lymphocyte activation antigen CD80 precursor [Homo sapiens] 56344 1845 0 26 0.001 0.207265719 7.695337711 Up 2.07E-06 5.78E-06 CABP5 4 GO:0044424//intracellular part GO:0046872//metal ion binding GO:0023052//signaling gi|11067753|ref|NP_062829.1|/4.14879e-92/calcium-binding protein 5 [Homo sapiens] 29113 1145 0 16 0.001 0.205525161 7.683171211 Up 0.000341308 0.000761915 C6orf15 2 GO:0005578//proteinaceous extracellular matrix GO:0005518//collagen binding;GO:0005539//glycosaminoglycan binding GO:0043062//extracellular structure organization gi|116517332|ref|NP_054789.2|/1.88473e-160/uncharacterized protein C6orf15 precursor [Homo sapiens] 283600 1733 0 23 0.001 0.195199982 7.608809111 Up 9.59E-06 2.51E-05 SLC25A47 2 GO:0019866//organelle inner membrane;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle - GO:0006810//transport gi|28207869|emb|CAD62588.1|/1.81247e-150/unnamed protein product [Homo sapiens] 404220 1664 0 22 0.001 0.194455333 7.603294994 Up 1.60E-05 4.10E-05 C6orf201 2 - GO:0005488//binding - gi|332823218|ref|XP_003311134.1|/5.09142e-86/PREDICTED: uncharacterized protein C6orf201-like [Pan troglodytes] 124857 3765 0 49 0.001 0.191417482 7.580578788 Up 1.66E-11 6.53E-11 WFIKKN2 5 - GO:0004866//endopeptidase inhibitor activity;GO:0005488//binding GO:0007178//transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0051346//negative regulation of hydrolase activity "gi|28212222|ref|NP_783165.1|/0/WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2 precursor [Homo sapiens]" 3240 1461 0 19 0.001 0.191273095 7.579490144 Up 7.38E-05 0.000178261 HP 1 GO:0043234//protein complex;GO:0044421//extracellular region part GO:0004175//endopeptidase activity;GO:0005515//protein binding GO:0000302//response to reactive oxygen species;GO:0006875//cellular metal ion homeostasis;GO:0008219//cell death;GO:0010727//negative regulation of hydrogen peroxide metabolic process;GO:0019538//protein metabolic process;GO:0043086//negative regulation of catalytic activity "gi|119579598|gb|EAW59194.1|/0/haptoglobin, isoform CRA_a [Homo sapiens]//gi|119579601|gb|EAW59197.1|/0/haptoglobin, isoform CRA_d [Homo sapiens]" 79853 2310 0 30 0.001 0.191011614 7.577516553 Up 2.69E-07 8.06E-07 TM4SF20 3 GO:0031224//intrinsic to membrane - - gi|188528611|ref|NP_079071.2|/8.05854e-112/transmembrane 4 L6 family member 20 [Homo sapiens] 653361 1409 0 18 0.001 0.187893611 7.553772199 Up 0.000122989 0.00028944 NCF1 4 GO:0000267//cell fraction;GO:0005887//integral to plasma membrane;GO:0044444//cytoplasmic part "GO:0005543//phospholipid binding;GO:0017111//nucleoside-triphosphatase activity;GO:0019904//protein domain specific binding;GO:0032561//guanyl ribonucleotide binding;GO:0050664//oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor" GO:0006605//protein targeting;GO:0006801//superoxide metabolic process;GO:0006952//defense response;GO:0009207 gi|115298672|ref|NP_000256.3|/0/neutrophil cytosol factor 1 [Homo sapiens] 100287596 1655 0 21 0.001 0.186625849 7.544005015 Up 2.66E-05 6.71E-05 DDX11L5 1 GO:0000785//chromatin;GO:0005819//spindle;GO:0043231//intracellular membrane-bounded organelle "GO:0004386//helicase activity;GO:0005488//binding;GO:0042623//ATPase activity, coupled" GO:0007059//chromosome segregation;GO:0051276//chromosome organization;GO:0051325//interphase gi|220675805|emb|CAQ52932.1|/9.9335e-64/DEAD/H box polypeptide 11 like 2 [Homo sapiens] 58511 1279 0 16 0.001 0.183992423 7.523502545 Up 0.000341308 0.000760845 DNASE2B 1 GO:0000323//lytic vacuole "GO:0016889//endodeoxyribonuclease activity, producing 3'-phosphomonoesters" GO:0044260 gi|133778285|gb|AAI26137.2|/2.16478e-157/Deoxyribonuclease II beta [Homo sapiens]//gi|8571464|gb|AAF76893.1|AF274571_1/0/deoxyribonuclease II beta [Homo sapiens] 50964 2322 0 28 0.001 0.177356176 7.470505759 Up 7.47E-07 2.16E-06 SOST 2 GO:0044421//extracellular region part GO:0005539//glycosaminoglycan binding GO:0001503//ossification;GO:0006461//protein complex assembly;GO:0030178//negative regulation of Wnt receptor signaling pathway;GO:0030509//BMP signaling pathway gi|13376846|ref|NP_079513.1|/3.65724e-96/sclerostin precursor [Homo sapiens] 26585 4150 0 50 0.001 0.177203546 7.469263662 Up 9.94E-12 3.97E-11 GREM1 1 GO:0044421//extracellular region part;GO:0044464//cell part GO:0005102//receptor binding GO:0001658//branching involved in ureteric bud morphogenesis;GO:0001837//epithelial to mesenchymal transition;GO:0001838//embryonic epithelial tube formation;GO:0002686//negative regulation of leukocyte migration;GO:0003002//regionalization;GO:0007154//cell communication;GO:0012501//programmed cell death;GO:0016049//cell growth;GO:0030509//BMP signaling pathway;GO:0035108//limb morphogenesis;GO:0042345//regulation of NF-kappaB import into nucleus;GO:0051091//positive regulation of sequence-specific DNA binding transcription factor activity;GO:0060231//mesenchymal to epithelial transition gi|300797307|ref|NP_001178251.1|/4.33811e-63/gremlin-1 isoform 3 [Homo sapiens]//gi|74149177|dbj|BAE22388.1|/1.99114e-71/unnamed protein product [Mus musculus]//gi|74149177|dbj|BAE22388.1|/5.22996e-91/unnamed protein product [Mus musculus] 55363 2210 0 26 0.001 0.173034051 7.434912158 Up 2.07E-06 5.79E-06 HEMGN 1 GO:0031981//nuclear lumen - GO:0030278//regulation of ossification;GO:0048869//cellular developmental process gi|37953336|gb|AAP75762.1|/0/hemogen [Homo sapiens] 132724 2645 0 31 0.001 0.172379858 7.429447397 Up 1.62E-07 4.93E-07 TMPRSS11B 3 GO:0016021//integral to membrane GO:0004175//endopeptidase activity GO:0019538//protein metabolic process gi|187761337|ref|NP_872308.2|/0/transmembrane protease serine 11B [Homo sapiens] 390212 1429 0 16 0.001 0.164679013 7.363512893 Up 0.000341308 0.000761558 GPR152 1 GO:0016020//membrane GO:0004872//receptor activity - gi|46243671|ref|NP_996880.1|/0/probable G-protein coupled receptor 152 [Homo sapiens] 493829 2152 0 24 0.001 0.164028561 7.357803232 Up 5.75E-06 1.54E-05 TRIM72 3 GO:0005886//plasma membrane;GO:0012506//vesicle membrane GO:0005543//phospholipid binding;GO:0046914//transition metal ion binding GO:0003008;GO:0007009//plasma membrane organization;GO:0016192//vesicle-mediated transport;GO:0048513//organ development;GO:0051259//protein oligomerization gi|270265876|ref|NP_001008275.2|/0/tripartite motif-containing protein 72 [Homo sapiens] 60385 1812 0 20 0.001 0.162338789 7.342863949 Up 4.43E-05 0.000109492 TSKS 1 - GO:0005488//binding - gi|11119430|ref|NP_068379.1|/0/testis-specific serine kinase substrate [Homo sapiens] 952 1494 0 16 0.001 0.157514263 7.299338661 Up 0.000341308 0.000762093 CD38 2 GO:0031224//intrinsic to membrane;GO:0042598;GO:0043231//intracellular membrane-bounded organelle "GO:0004871//signal transducer activity;GO:0016799//hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0016829//lyase activity" GO:0006917//induction of apoptosis;GO:0006979//response to oxidative stress;GO:0016049//cell growth;GO:0019229//regulation of vasoconstriction;GO:0022414//reproductive process;GO:0030888//regulation of B cell proliferation;GO:0032845;GO:0033189//response to vitamin A;GO:0034097//response to cytokine stimulus;GO:0043627//response to estrogen stimulus;GO:0048167//regulation of synaptic plasticity;GO:0050796//regulation of insulin secretion;GO:0050851//antigen receptor-mediated signaling pathway;GO:0051480//cytosolic calcium ion homeostasis gi|38454326|ref|NP_001766.2|/8.70943e-167/ADP-ribosyl cyclase 1 [Homo sapiens] 57084 3938 0 42 0.001 0.156864287 7.293373121 Up 5.90E-10 2.12E-09 SLC17A6 2 GO:0005624//membrane fraction;GO:0005768//endosome;GO:0008021//synaptic vesicle;GO:0031224//intrinsic to membrane;GO:0044459//plasma membrane part GO:0015172//acidic amino acid transmembrane transporter activity;GO:0015291//secondary active transmembrane transporter activity GO:0001505//regulation of neurotransmitter levels;GO:0006865//amino acid transport;GO:0015711//organic anion transport;GO:0030001//metal ion transport gi|9966811|ref|NP_065079.1|/0/vesicular glutamate transporter 2 [Homo sapiens] 56169 2731 0 29 0.001 0.156180496 7.28707049 Up 4.49E-07 1.32E-06 GSDMC 2 GO:0043231//intracellular membrane-bounded organelle - - gi|13899221|ref|NP_113603.1|/0/gasdermin-C [Homo sapiens] 3249 2389 0 25 0.001 0.153912665 7.265968145 Up 3.45E-06 9.47E-06 HPN 2 GO:0016021//integral to membrane;GO:0044424//intracellular part GO:0004175//endopeptidase activity;GO:0004888//transmembrane signaling receptor activity GO:0019538//protein metabolic process;GO:0023052//signaling;GO:0040007//growth gi|4504481|ref|NP_002142.1|/0/serine protease hepsin [Homo sapiens] 92749 2515 0 26 0.001 0.152049802 7.248400127 Up 2.07E-06 5.78E-06 CCDC164 2 - - - gi|217416374|ref|NP_659475.2|/0/coiled-coil domain-containing protein 164 [Homo sapiens] 285051 2139 0 22 0.001 0.15127334 7.241013945 Up 1.60E-05 4.10E-05 C2orf61 2 - - - gi|254675143|ref|NP_001157033.1|/3.26559e-140/uncharacterized protein C2orf61 isoform 1 [Homo sapiens] //gi|27735115|ref|NP_775920.1|/6.05572e-98/uncharacterized protein C2orf61 isoform 2 [Homo sapiens] 344191 1617 0 16 0.001 0.145532659 7.18519913 Up 0.000341308 0.000760667 EVX2 1 - GO:0003676//nucleic acid binding GO:0035107//appendage morphogenesis gi|122937319|ref|NP_001073927.1|/2.72319e-161/homeobox even-skipped homolog protein 2 [Homo sapiens] 79792 2326 0 23 0.001 0.145434896 7.184229668 Up 9.59E-06 2.51E-05 GSDMD 1 - - GO:0007154//cell communication "gi|119602652|gb|EAW82246.1|/0/gasdermin domain containing 1, isoform CRA_d [Homo sapiens]" 1674 2268 0 22 0.001 0.142669169 7.156529787 Up 1.60E-05 4.10E-05 DES 3 GO:0000267//cell fraction;GO:0005882//intermediate filament;GO:0005886//plasma membrane;GO:0031674//I band GO:0005198//structural molecule activity;GO:0005488//binding GO:0006936//muscle contraction;GO:0006996//organelle organization;GO:0044057 gi|148728589|gb|ABR08708.1|/0/mutant desmin [Homo sapiens] 93010 3641 0 35 0.001 0.141383219 7.143467085 Up 2.10E-08 6.82E-08 B3GNT7 2 GO:0012505//endomembrane system;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle "GO:0016758//transferase activity, transferring hexosyl groups" GO:0006464//cellular protein modification process "gi|21687139|ref|NP_660279.1|/0/UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 [Homo sapiens]" 254272 1978 0 19 0.001 0.141279066 7.142403896 Up 7.38E-05 0.000178307 TBC1D28 2 GO:0044464//cell part GO:0005099//Ras GTPase activator activity GO:0032318//regulation of Ras GTPase activity gi|151108489|ref|NP_001034486.2|/6.27932e-118/TBC1 domain family member 28 [Homo sapiens] 54681 2294 0 22 0.001 0.141052169 7.140085036 Up 1.60E-05 4.10E-05 P4HTM 2 GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle "GO:0016701//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0019842//vitamin binding;GO:0046914//transition metal ion binding" GO:0008152//metabolic process gi|29570771|ref|NP_808808.1|/0/transmembrane prolyl 4-hydroxylase isoform a [Homo sapiens]//gi|64085083|ref|NP_808807.2|/0/transmembrane prolyl 4-hydroxylase isoform c [Homo sapiens] 642636 1808 0 17 0.001 0.138293254 7.111586973 Up 0.000204884 0.000469924 RAD21L1 2 GO:0008278//cohesin complex;GO:0043231//intracellular membrane-bounded organelle - GO:0007127//meiosis I gi|222136644|ref|NP_001130038.2|/0/double-strand-break repair protein rad21-like protein 1 [Homo sapiens] 1014 2986 0 28 0.001 0.137917294 7.107659566 Up 7.47E-07 2.16E-06 CDH16 1 GO:0016020//membrane;GO:0031224//intrinsic to membrane GO:0046872//metal ion binding GO:0007155//cell adhesion;GO:0016337//cell-cell adhesion gi|325296969|ref|NP_001191673.1|/0/cadherin-16 isoform 2 precursor [Homo sapiens]//gi|325296973|ref|NP_001191674.1|/0/cadherin-16 isoform 3 precursor [Homo sapiens] //gi|325296975|ref|NP_001191675.1|/0/cadherin-16 isoform 4 precursor [Homo sapiens]//gi|4757956|ref|NP_004053.1|/0/cadherin-16 isoform 1 precursor [Homo sapiens] 11085 3006 0 28 0.001 0.136999681 7.098028722 Up 7.47E-07 2.16E-06 ADAM30 3 GO:0031224//intrinsic to membrane GO:0004175//endopeptidase activity;GO:0046914//transition metal ion binding GO:0019538//protein metabolic process gi|20306262|gb|AAH28372.1|/0/ADAM metallopeptidase domain 30 [Homo sapiens] 3684 4745 0 44 0.001 0.136385111 7.09154234 Up 2.12E-10 7.83E-10 ITGAM 1 GO:0005887//integral to plasma membrane;GO:0009986//cell surface;GO:0043231//intracellular membrane-bounded organelle GO:0004871//signal transducer activity;GO:0005539//glycosaminoglycan binding;GO:0043394//proteoglycan binding GO:0007166//cell surface receptor signaling pathway;GO:0007599//hemostasis;GO:0016337//cell-cell adhesion;GO:0030595//leukocyte chemotaxis;GO:0042098//T cell proliferation gi|224831239|ref|NP_001139280.1|/0/integrin alpha-M isoform 1 precursor [Homo sapiens]//gi|88501734|ref|NP_000623.2|/0/integrin alpha-M isoform 2 precursor [Homo sapiens] 353288 1748 0 16 0.001 0.134626035 7.072813624 Up 0.000341308 0.000761469 KRT26 4 GO:0043234//protein complex - - "gi|254675185|ref|NP_853517.2|/0/keratin, type I cytoskeletal 26 [Homo sapiens]" 646658 2629 0 24 0.001 0.134267578 7.068967168 Up 5.75E-06 1.54E-05 SYNDIG1L 1 GO:0016020//membrane;GO:0043231//intracellular membrane-bounded organelle - - gi|119601581|gb|EAW81175.1|/4.04242e-127/hCG1786373 [Homo sapiens] 400046 3181 0 29 0.001 0.13408643 7.067019432 Up 4.49E-07 1.32E-06 FLJ41278 1 - - - gi|397508836|ref|XP_003824846.1|/6.14522e-60/PREDICTED: uncharacterized protein LOC100988397 [Pan paniscus] 5008 1869 0 17 0.001 0.13377967 7.063715081 Up 0.000204884 0.000469754 OSM 4 GO:0005887//integral to plasma membrane;GO:0044421//extracellular region part GO:0005126//cytokine receptor binding GO:0001934//positive regulation of protein phosphorylation;GO:0002376//immune system process;GO:0002526//acute inflammatory response;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0007260//tyrosine phosphorylation of STAT protein;GO:0007399//nervous system development;GO:0007610//behavior;GO:0008283//cell proliferation;GO:0010740//positive regulation of intracellular protein kinase cascade;GO:0010948;GO:0012501//programmed cell death;GO:0046883//regulation of hormone secretion gi|10092621|ref|NP_065391.1|/1.09504e-132/oncostatin-M preproprotein [Homo sapiens] 121214 1765 0 16 0.001 0.133329353 7.058850626 Up 0.000341308 0.000761112 SDR9C7 2 GO:0044424//intracellular part GO:0003824//catalytic activity GO:0008152//metabolic process gi|22507405|ref|NP_683695.1|/2.10595e-178/short-chain dehydrogenase/reductase family 9C member 7 [Homo sapiens] 90167 3227 0 29 0.001 0.132175065 7.046306226 Up 4.49E-07 1.32E-06 FRMD7 2 GO:0030427//site of polarized growth;GO:0042995//cell projection;GO:0043232;GO:0044297//cell body - GO:0031175//neuron projection development gi|34916000|ref|NP_919253.1|/0/FERM domain-containing protein 7 [Homo sapiens] 285593 1781 1 197 0.012402218 1.626869836 7.03535684 Up 2.09E-42 2.30E-41 LOC285593 1 - - - gi|119581801|gb|EAW61397.1|/2.30809e-15/hCG1979273 [Homo sapiens] 51617 2473 0 22 0.001 0.13084257 7.031688188 Up 1.60E-05 4.10E-05 HMP19 4 GO:0000139//Golgi membrane;GO:0005771//multivesicular body;GO:0012506//vesicle membrane;GO:0031224//intrinsic to membrane GO:0001664//G-protein coupled receptor binding GO:0007186//G-protein coupled receptor signaling pathway gi|7706284|ref|NP_057064.1|/2.83212e-94/neuron-specific protein family member 2 [Homo sapiens] 84839 2190 0 19 0.001 0.127602736 6.995515453 Up 7.38E-05 0.000178171 RAX2 3 GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0003677//DNA binding "GO:0006351//transcription, DNA-dependent;GO:0032501//multicellular organismal process" gi|119589694|gb|EAW69288.1|/4.67818e-53/retina and anterior neural fold homeobox like 1 [Homo sapiens] 4114 2310 0 20 0.001 0.127341076 6.992554052 Up 4.43E-05 0.000109464 MAGEB3 4 - - - gi|29171714|ref|NP_002356.2|/0/melanoma-associated antigen B3 [Homo sapiens] 126668 2544 0 22 0.001 0.12719091 6.990851757 Up 1.60E-05 4.10E-05 TDRD10 1 - GO:0003676//nucleic acid binding - gi|148613864|ref|NP_872305.3|/0/tudor domain-containing protein 10 isoform b [Homo sapiens]//gi|148613866|ref|NP_001091945.1|/0/tudor domain-containing protein 10 isoform a [Homo sapiens] 4688 2429 0 21 0.001 0.127157588 6.990473742 Up 2.66E-05 6.71E-05 NCF2 1 GO:0005626//insoluble fraction;GO:0005887//integral to plasma membrane;GO:0030141//secretory granule;GO:0031981//nuclear lumen "GO:0017048//Rho GTPase binding;GO:0050664//oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor" GO:0002237//response to molecule of bacterial origin;GO:0006801//superoxide metabolic process;GO:0006952//defense response;GO:0008217//regulation of blood pressure;GO:0009746;GO:0032502//developmental process;GO:0034405//response to fluid shear stress;GO:0043065//positive regulation of apoptotic process;GO:0048545//response to steroid hormone stimulus gi|299829279|ref|NP_001177718.1|/0/neutrophil cytosol factor 2 isoform 3 [Homo sapiens]//gi|299829294|ref|NP_001177723.1|/0/neutrophil cytosol factor 2 isoform 2 [Homo sapiens]//gi|67189970|ref|NP_000424.2|/0/neutrophil cytosol factor 2 isoform 1 [Homo sapiens] 283847 2446 0 21 0.001 0.126273827 6.980411828 Up 2.66E-05 6.71E-05 CCDC79 1 - GO:0003676//nucleic acid binding - gi|211059433|ref|NP_001129977.1|/0/coiled-coil domain-containing protein 79 [Homo sapiens] 4600 2961 0 25 0.001 0.124180128 6.956290508 Up 3.45E-06 9.47E-06 MX2 1 GO:0043231//intracellular membrane-bounded organelle GO:0017111//nucleoside-triphosphatase activity;GO:0032561//guanyl ribonucleotide binding GO:0006950//response to stress;GO:0009207;GO:0019221//cytokine-mediated signaling pathway;GO:0051707//response to other organism gi|11342664|ref|NP_002454.1|/0/interferon-induced GTP-binding protein Mx2 [Homo sapiens] 146183 3624 0 30 0.001 0.121754092 6.927826449 Up 2.69E-07 8.06E-07 OTOA 1 GO:0031012//extracellular matrix;GO:0031224//intrinsic to membrane;GO:0044459//plasma membrane part - GO:0050954//sensory perception of mechanical stimulus gi|239735575|ref|NP_001155155.1|/0/otoancorin isoform 3 [Homo sapiens] //gi|24638452|ref|NP_733764.1|/0/otoancorin isoform 2 [Homo sapiens] //gi|77404409|ref|NP_653273.3|/0/otoancorin isoform 1 precursor [Homo sapiens] 3783 2240 0 18 0.001 0.118188436 6.884945078 Up 0.000122989 0.000289226 KCNN4 2 GO:0005887//integral to plasma membrane GO:0005227//calcium activated cation channel activity;GO:0005515//protein binding GO:0006950//response to stress;GO:0007589//body fluid secretion;GO:0015914//phospholipid transport;GO:0019725//cellular homeostasis;GO:0030001//metal ion transport;GO:0034220//ion transmembrane transport;GO:0048522//positive regulation of cellular process gi|4504859|ref|NP_002241.1|/0/intermediate conductance calcium-activated potassium channel protein 4 [Homo sapiens] 55124 3997 0 32 0.001 0.117751468 6.879601236 Up 9.70E-08 3.01E-07 PIWIL2 1 GO:0030529//ribonucleoprotein complex;GO:0043186//P granule GO:0003723//RNA binding GO:0006306//DNA methylation;GO:0006396//RNA processing;GO:0006412//translation;GO:0007127//meiosis I;GO:0007292//female gamete generation;GO:0016458//gene silencing;GO:0019827//stem cell maintenance;GO:0034660//ncRNA metabolic process;GO:0048232//male gamete generation gi|24431985|ref|NP_060538.2|/0/piwi-like protein 2 [Homo sapiens] 401375 3010 0 24 0.001 0.117272247 6.873717823 Up 5.75E-06 1.54E-05 GTF2IRD2P1 1 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding - gi|397478009|ref|XP_003810351.1|/0/PREDICTED: general transcription factor II-I repeat domain-containing protein 2B [Pan paniscus] 5535 3401 0 27 0.001 0.116763642 6.867447305 Up 1.24E-06 3.54E-06 PPP3R2 2 GO:0008287//protein serine/threonine phosphatase complex;GO:0044444//cytoplasmic part GO:0004722//protein serine/threonine phosphatase activity;GO:0005515//protein binding;GO:0046872//metal ion binding GO:0000904//cell morphogenesis involved in differentiation;GO:0001525//angiogenesis;GO:0006464//cellular protein modification process;GO:0006917//induction of apoptosis;GO:0030855//epithelial cell differentiation;GO:0042991//transcription factor import into nucleus;GO:0048513//organ development gi|22212896|ref|NP_671709.1|/2.72521e-82/calcineurin subunit B type 2 [Homo sapiens] 131578 5940 0 47 0.001 0.116375595 6.86264473 Up 4.60E-11 1.77E-10 LRRC15 4 GO:0031224//intrinsic to membrane - - gi|288541295|ref|NP_001128529.2|/0/leucine-rich repeat-containing protein 15 isoform a precursor [Homo sapiens] 441151 4637 0 36 0.001 0.114186801 6.835252084 Up 1.26E-08 4.16E-08 TMEM151B 1 GO:0031224//intrinsic to membrane - - gi|387542870|gb|AFJ72062.1|/0/transmembrane protein 151B [Macaca mulatta] 55998 2062 0 16 0.001 0.114125271 6.834474476 Up 0.000341308 0.000760756 NXF5 2 GO:0005856//cytoskeleton;GO:0031981//nuclear lumen;GO:0043234//protein complex GO:0003676//nucleic acid binding;GO:0005215//transporter activity GO:0006405//RNA export from nucleus;GO:0032501//multicellular organismal process gi|13430854|ref|NP_071336.1|/0/nuclear RNA export factor 2 [Homo sapiens] 149620 2844 0 22 0.001 0.113774147 6.830028963 Up 1.60E-05 4.10E-05 RP11-165H20.1 1 GO:0044421//extracellular region part;GO:0044424//intracellular part "GO:0004553//hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0019899//enzyme binding;GO:0030247//polysaccharide binding;GO:0043167//ion binding" GO:0002376//immune system process;GO:0006026;GO:0006030//chitin metabolic process;GO:0012501//programmed cell death;GO:0032722//positive regulation of chemokine production;GO:0042221//response to chemical stimulus;GO:0051707//response to other organism gi|390466373|ref|XP_002751292.2|/1.30075e-160/PREDICTED: probable chitinase 3-like [Callithrix jacchus] 85009 2127 0 16 0.001 0.110637663 6.789698776 Up 0.000341308 0.000761023 MGC16025 1 - - - gi|119591574|gb|EAW71168.1|/1.01446e-20/hCG1818858 [Homo sapiens] 140 2161 0 17 0.001 0.110585671 6.789020658 Up 0.000204884 0.000469584 ADORA3 1 GO:0016021//integral to membrane GO:0004930//G-protein coupled receptor activity GO:0002441;GO:0009967//positive regulation of signal transduction;GO:0031349//positive regulation of defense response;GO:0033008;GO:0035588;GO:0044057;GO:0045762//positive regulation of adenylate cyclase activity;GO:0048243//norepinephrine secretion;GO:0051047//positive regulation of secretion gi|130978672|ref|NP_001075445.1|/5.21715e-137/adenosine receptor A3 isoform 3 [Homo sapiens]//gi|4501953|ref|NP_000668.1|/1.01459e-167/adenosine receptor A3 isoform 2 [Homo sapiens]//gi|46559769|ref|NP_065734.5|/1.86179e-179/adenosine receptor A3 isoform 1 [Homo sapiens] 134466 2420 0 18 0.001 0.109397561 6.773436763 Up 0.000122989 0.000289333 ZNF300P1 1 GO:0005622//intracellular GO:0046872//metal ion binding - gi|345799122|ref|XP_003434523.1|/0/PREDICTED: zinc finger protein 850-like [Canis lupus familiaris] 11148 2689 0 20 0.001 0.109393041 6.773377149 Up 4.43E-05 0.000109435 HHLA2 2 GO:0031224//intrinsic to membrane - - gi|5901964|ref|NP_009003.1|/0/HERV-H LTR-associating protein 2 precursor [Homo sapiens] 643529 4309 0 32 0.001 0.109225486 6.771165711 Up 9.70E-08 3.01E-07 LOC643529 1 GO:0044464//cell part GO:0016740//transferase activity GO:0009987//cellular process gi|57920|emb|CAA50040.1|/7.15617e-49/serine/threonine protein kinase [Mus musculus] 200008 2723 0 20 0.001 0.108027134 6.755249922 Up 4.43E-05 0.000109478 CDCP2 2 - - - gi|72384339|ref|NP_963840.2|/0/CUB domain-containing protein 2 precursor [Homo sapiens] 284998 2454 0 18 0.001 0.107881865 6.753308562 Up 0.000122989 0.000289012 LOC284998 1 - - - gi|119622181|gb|EAX01776.1|/3.2597e-34/hCG1986859 [Homo sapiens] 100271702 2352 0 17 0.001 0.106307059 6.73209359 Up 0.000204884 0.000469697 LOC100271702 1 - - - gi|119609323|gb|EAW88917.1|/1.61396e-99/hCG2002101 [Homo sapiens] 286380 2218 0 16 0.001 0.106098426 6.729259444 Up 0.000341308 0.000760578 FOXD4L3 4 GO:0031981//nuclear lumen;GO:0043234//protein complex GO:0000981//sequence-specific DNA binding RNA polymerase II transcription factor activity;GO:0005515//protein binding;GO:0043565//sequence-specific DNA binding;GO:0043566//structure-specific DNA binding GO:0000122//negative regulation of transcription from RNA polymerase II promoter;GO:0001667//ameboidal cell migration;GO:0001822//kidney development;GO:0021782//glial cell development;GO:0030509//BMP signaling pathway;GO:0048675//axon extension;GO:0050931//pigment cell differentiation;GO:0060600 gi|34596581|gb|AAQ76878.1|/0/FOXD4 [Homo sapiens] 84985 2946 0 21 0.001 0.104842424 6.712078802 Up 2.66E-05 6.70E-05 FAM83A 1 - - - gi|40254997|ref|NP_116288.2|/0/protein FAM83A isoform a [Homo sapiens]//gi|46255017|ref|NP_996889.1|/0/protein FAM83A isoform b [Homo sapiens] 56253 2422 0 17 0.001 0.103234601 6.689782785 Up 0.000204884 0.000469867 CRTAM 2 GO:0031224//intrinsic to membrane GO:0005515//protein binding GO:0001912//positive regulation of leukocyte mediated cytotoxicity;GO:0002420;GO:0042098//T cell proliferation;GO:0050707//regulation of cytokine secretion gi|51593098|ref|NP_062550.2|/0/cytotoxic and regulatory T-cell molecule precursor [Homo sapiens] 213 2264 2 308 0.019512677 2.000897282 6.680091561 Up 5.07E-65 8.43E-64 ALB 5 GO:0005578//proteinaceous extracellular matrix;GO:0031091//platelet alpha granule;GO:0032991//macromolecular complex GO:0003676//nucleic acid binding;GO:0005515//protein binding;GO:0008289//lipid binding;GO:0046914//transition metal ion binding;GO:0048037//cofactor binding "GO:0001775//cell activation;GO:0001897;GO:0006887//exocytosis;GO:0006915//apoptotic process;GO:0007599//hemostasis;GO:0008202//steroid metabolic process;GO:0010038//response to metal ion;GO:0015711//organic anion transport;GO:0015718//monocarboxylic acid transport;GO:0031669//cellular response to nutrient levels;GO:0044260;GO:0045188//regulation of circadian sleep/wake cycle, non-REM sleep;GO:0051657" gi|4502027|ref|NP_000468.1|/0/serum albumin preproprotein [Homo sapiens] 79865 3758 0 26 0.001 0.101757651 6.66899346 Up 2.07E-06 5.78E-06 TREML2 2 GO:0031224//intrinsic to membrane GO:0004871//signal transducer activity;GO:0005488//binding GO:0046649//lymphocyte activation gi|56204302|emb|CAI19909.1|/0/triggering receptor expressed on myeloid cells-like 2 [Homo sapiens] 647288 2664 0 18 0.001 0.099377664 6.634849728 Up 0.000122989 0.000289512 CTAGE11P 1 - - - gi|395745430|ref|XP_002824382.2|/0/PREDICTED: LOW QUALITY PROTEIN: putative protein cTAGE-6 [Pongo abelii] 54440 2707 0 18 0.001 0.097799076 6.611748923 Up 0.000122989 0.000289369 SASH3 3 GO:0043231//intracellular membrane-bounded organelle - "GO:0001819//positive regulation of cytokine production;GO:0001894//tissue homeostasis;GO:0002369//T cell cytokine production;GO:0002377//immunoglobulin production;GO:0002696//positive regulation of leukocyte activation;GO:0030888//regulation of B cell proliferation;GO:0042098//T cell proliferation;GO:0043370//regulation of CD4-positive, alpha-beta T cell differentiation;GO:0045927//positive regulation of growth" gi|9506363|ref|NP_061863.1|/2.96012e-177/SAM and SH3 domain-containing protein 3 [Homo sapiens] 401136 3202 0 21 0.001 0.096460269 6.591862924 Up 2.66E-05 6.71E-05 TMPRSS11BNL 2 GO:0016021//integral to membrane GO:0004175//endopeptidase activity GO:0019538//protein metabolic process gi|194018584|ref|NP_001123379.1|/2.9415e-54/transmembrane protease serine 11B-like protein [Homo sapiens] 6010 2768 0 18 0.001 0.095643821 6.579599868 Up 0.000122989 0.000289119 RHO 3 GO:0001750//photoreceptor outer segment;GO:0016021//integral to membrane;GO:0043231//intracellular membrane-bounded organelle GO:0004888//transmembrane signaling receptor activity;GO:0032561//guanyl ribonucleotide binding;GO:0043169//cation binding "GO:0006464//cellular protein modification process;GO:0007186//G-protein coupled receptor signaling pathway;GO:0007603//phototransduction, visible light;GO:0048856//anatomical structure development;GO:0050953//sensory perception of light stimulus" gi|4506527|ref|NP_000530.1|/0/rhodopsin [Homo sapiens] 344454 3738 0 24 0.001 0.094432708 6.561214741 Up 5.75E-06 1.54E-05 AOX2P 4 - GO:0000166//nucleotide binding;GO:0003824//catalytic activity;GO:0046914//transition metal ion binding;GO:0050662//coenzyme binding;GO:0051536//iron-sulfur cluster binding GO:0008152//metabolic process gi|297264657|ref|XP_001089912.2|/0/PREDICTED: aldehyde oxidase-like [Macaca mulatta] 149461 3602 0 23 0.001 0.093914928 6.553282584 Up 9.59E-06 2.52E-05 CLDN19 1 GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0043296//apical junction complex GO:0005515//protein binding GO:0007043//cell-cell junction assembly;GO:0016337//cell-cell adhesion;GO:0050953//sensory perception of light stimulus gi|183979973|ref|NP_683763.2|/1.39583e-116/claudin-19 isoform a [Homo sapiens]//gi|183979975|ref|NP_001116867.1|/4.76277e-109/claudin-19 isoform b [Homo sapiens]//gi|297515502|ref|NP_001172046.1|/4.20904e-94/claudin-19 isoform c [Homo sapiens] 3361 4572 0 29 0.001 0.093291543 6.543674401 Up 4.49E-07 1.32E-06 HTR5A 3 GO:0005783//endoplasmic reticulum;GO:0016021//integral to membrane;GO:0043005//neuron projection;GO:0043025//neuronal cell body GO:0008227//G-protein coupled amine receptor activity GO:0007186//G-protein coupled receptor signaling pathway;GO:0019935//cyclic-nucleotide-mediated signaling;GO:0021543//pallium development;GO:0043627//response to estrogen stimulus gi|109730487|gb|AAI13469.1|/0/5-hydroxytryptamine (serotonin) receptor 5A [Homo sapiens] 78997 2855 0 18 0.001 0.092729281 6.534953065 Up 0.000122989 0.000289083 GDAP1L1 1 - - - gi|16551599|dbj|BAB71128.1|/5.43563e-176/unnamed protein product [Homo sapiens]//gi|30581160|ref|NP_076939.3|/0/ganglioside-induced differentiation-associated protein 1-like 1 isoform 2 [Homo sapiens]//gi|376319237|ref|NP_001243666.1|/0/ganglioside-induced differentiation-associated protein 1-like 1 isoform 1 [Homo sapiens] //gi|376319241|ref|NP_001243668.1|/6.59703e-166/ganglioside-induced differentiation-associated protein 1-like 1 isoform 4 [Homo sapiens] //gi|376319244|ref|NP_001243669.1|/1.18368e-159/ganglioside-induced differentiation-associated protein 1-like 1 isoform 5 [Homo sapiens]//gi|395829028|ref|XP_003787663.1|/2.76773e-102/PREDICTED: ganglioside-induced differentiation-associated protein 1-like 1 isoform 2 [Otolemur garnettii] 151888 3216 0 20 0.001 0.091467004 6.515179497 Up 4.43E-05 0.000109449 BTLA 1 GO:0009986//cell surface;GO:0016021//integral to membrane GO:0004871//signal transducer activity GO:0002764//immune response-regulating signaling pathway;GO:0030888//regulation of B cell proliferation;GO:0031294;GO:0042130//negative regulation of T cell proliferation gi|145580619|ref|NP_001078826.1|/4.36485e-140/B- and T-lymphocyte attenuator isoform 2 [Homo sapiens]//gi|296439425|sp|Q7Z6A9.3|BTLA_HUMAN/1.99187e-151/RecName: Full=B- and T-lymphocyte attenuator; AltName: Full=B- and T-lymphocyte-associated protein; AltName: CD_antigen=CD272; Flags: Precursor 116379 2910 0 18 0.001 0.090976666 6.507424657 Up 0.000122989 0.000289655 IL22RA2 2 GO:0044421//extracellular region part GO:0004896//cytokine receptor activity GO:0042503//tyrosine phosphorylation of Stat3 protein gi|31317241|ref|NP_851826.1|/2.7477e-133/interleukin-22 receptor subunit alpha-2 isoform 2 precursor [Homo sapiens]//gi|31317243|ref|NP_851827.1|/1.92538e-72/interleukin-22 receptor subunit alpha-2 isoform 3 precursor [Homo sapiens]//gi|37182593|gb|AAQ89097.1|/4.50915e-155/IL22RA2 [Homo sapiens] 340745 3096 0 19 0.001 0.090261625 6.496040851 Up 7.38E-05 0.000178239 LRIT2 2 GO:0031224//intrinsic to membrane - - "gi|62988340|ref|NP_001017924.1|/0/leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 precursor [Homo sapiens]" 79742 4735 0 29 0.001 0.090080028 6.493135379 Up 4.49E-07 1.32E-06 CXorf36 2 - - - gi|193804854|ref|NP_789789.2|/0/deleted in autism-related protein 1 isoform 1 precursor [Homo sapiens]//gi|193804856|ref|NP_078965.2|/1.60775e-84/deleted in autism-related protein 1 isoform 2 precursor [Homo sapiens] 63934 4479 0 27 0.001 0.088661118 6.470229645 Up 1.24E-06 3.54E-06 ZNF667 3 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding "GO:0006351//transcription, DNA-dependent" "gi|119592860|gb|EAW72454.1|/0/zinc finger protein 667, isoform CRA_b [Homo sapiens]" 93589 5343 0 31 0.001 0.085334966 6.415065102 Up 1.62E-07 4.93E-07 CACNA2D4 4 GO:0031224//intrinsic to membrane GO:0005261//cation channel activity;GO:0043169//cation binding GO:0006810//transport;GO:0050953//sensory perception of light stimulus gi|132566536|ref|NP_758952.4|/0/voltage-dependent calcium channel subunit alpha-2/delta-4 [Homo sapiens] 128209 3131 0 18 0.001 0.084555125 6.401820302 Up 0.000122989 0.000289619 KLF17 3 GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0043565//sequence-specific DNA binding;GO:0046914//transition metal ion binding "GO:0006355//regulation of transcription, DNA-dependent;GO:0019953//sexual reproduction" gi|104294874|ref|NP_775755.3|/0/Krueppel-like factor 17 [Homo sapiens] 4882 3447 2 252 0.012815985 1.075250759 6.390584944 Up 8.81E-53 1.19E-51 NPR2 3 GO:0005626//insoluble fraction;GO:0031224//intrinsic to membrane GO:0001653//peptide receptor activity;GO:0005515//protein binding;GO:0009975//cyclase activity;GO:0016301//kinase activity;GO:0016829//lyase activity;GO:0032559;GO:0032561//guanyl ribonucleotide binding GO:0006164//purine nucleotide biosynthetic process;GO:0006464//cellular protein modification process;GO:0007167//enzyme linked receptor protein signaling pathway;GO:0008015//blood circulation;GO:0009124//nucleoside monophosphate biosynthetic process;GO:0048856//anatomical structure development gi|4580422|ref|NP_003986.2|/0/atrial natriuretic peptide receptor 2 precursor [Homo sapiens] 84675 2859 0 16 0.001 0.082310706 6.363008189 Up 0.000341308 0.00076129 TRIM55 1 GO:0015630//microtubule cytoskeleton;GO:0043231//intracellular membrane-bounded organelle GO:0046914//transition metal ion binding;GO:0060089 GO:0023052//signaling gi|34878821|ref|NP_149047.2|/0/tripartite motif-containing protein 55 isoform 2 [Homo sapiens]//gi|34878836|ref|NP_908973.1|/0/tripartite motif-containing protein 55 isoform 1 [Homo sapiens]//gi|34878844|ref|NP_908974.1|/0/tripartite motif-containing protein 55 isoform 3 [Homo sapiens]//gi|34878852|ref|NP_908975.1|/1.56525e-123/tripartite motif-containing protein 55 isoform 4 [Homo sapiens] 196996 3318 0 18 0.001 0.079789662 6.318129924 Up 0.000122989 0.000289048 GRAMD2 2 GO:0031224//intrinsic to membrane - - gi|60593095|ref|NP_001012660.1|/0/GRAM domain-containing protein 2 [Homo sapiens] 58985 2988 0 16 0.001 0.078757131 6.299338661 Up 0.000341308 0.000760489 IL22RA1 3 GO:0031224//intrinsic to membrane GO:0004896//cytokine receptor activity - gi|31317239|ref|NP_067081.2|/0/interleukin-22 receptor subunit alpha-1 precursor [Homo sapiens] 29850 3946 0 21 0.001 0.078273132 6.290445276 Up 2.66E-05 6.71E-05 TRPM5 3 GO:0031224//intrinsic to membrane GO:0004871//signal transducer activity;GO:0005216//ion channel activity GO:0006810//transport gi|11225266|ref|NP_055370.1|/0/transient receptor potential cation channel subfamily M member 5 [Homo sapiens] 127435 3417 0 18 0.001 0.077477933 6.275713563 Up 0.000122989 0.000289583 PODN 1 GO:0031012//extracellular matrix;GO:0044421//extracellular region part;GO:0044424//intracellular part GO:0005515//protein binding GO:0008283//cell proliferation;GO:0016477//cell migration gi|312283621|ref|NP_001186009.1|/0/podocan isoform 2 [Homo sapiens]//gi|312283627|ref|NP_001186011.1|/0/podocan isoform 3 [Homo sapiens]//gi|45505137|ref|NP_714914.2|/0/podocan isoform 1 [Homo sapiens] 93377 3629 0 19 0.001 0.077004682 6.266874266 Up 7.38E-05 0.000178284 OPALIN 3 GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle - - gi|15082236|ref|NP_149984.1|/1.1066e-65/opalin isoform a [Homo sapiens]//gi|15082236|ref|NP_149984.1|/6.79641e-63/opalin isoform a [Homo sapiens]//gi|91932795|ref|NP_001035191.1|/3.99324e-52/opalin isoform b [Homo sapiens] 100130899 4246 0 22 0.001 0.076206706 6.251846057 Up 1.60E-05 4.10E-05 LOC100130899 1 - - - gi|119604242|gb|EAW83836.1|/2.1826e-24/hCG2014340 [Homo sapiens] 135656 5306 0 27 0.001 0.074842282 6.225781636 Up 1.24E-06 3.54E-06 DPCR1 3 - - - gi|238624188|ref|NP_543146.2|/0/diffuse panbronchiolitis critical region protein 1 precursor [Homo sapiens] 375612 3191 0 16 0.001 0.073746885 6.2045102 Up 0.000341308 0.000760934 LHFPL3 2 GO:0031224//intrinsic to membrane - - gi|120538345|gb|AAI29938.1|/2.97832e-115/Lipoma HMGIC fusion partner-like 3 [Homo sapiens] 149837 3591 0 18 0.001 0.073723781 6.204058158 Up 0.000122989 0.000289155 LOC149837 1 - - - gi|158260963|dbj|BAF82659.1|/1.31451e-50/unnamed protein product [Homo sapiens] 6514 3439 0 17 0.001 0.072705497 6.183992534 Up 0.000204884 0.000469641 SLC2A2 1 GO:0005626//insoluble fraction;GO:0016021//integral to membrane;GO:0042995//cell projection;GO:0044424//intracellular part GO:0005355//glucose transmembrane transporter activity;GO:0051183//vitamin transporter activity GO:0006629//lipid metabolic process;GO:0008645//hexose transport;GO:0015980//energy derivation by oxidation of organic compounds;GO:0030073//insulin secretion;GO:0031016//pancreas development;GO:0051180//vitamin transport "gi|4557851|ref|NP_000331.1|/0/solute carrier family 2, facilitated glucose transporter member 2 [Homo sapiens]" 155006 3398 0 16 0.001 0.069254358 6.113832957 Up 0.000341308 0.000762004 TMEM213 1 GO:0031224//intrinsic to membrane - - gi|124297107|gb|AAI31698.1|/4.36669e-64/TMEM213 protein [Homo sapiens] 3952 3444 0 16 0.001 0.068329358 6.094433666 Up 0.000341308 0.000761647 LEP 2 GO:0044421//extracellular region part GO:0051427 GO:0006094//gluconeogenesis;GO:0006631//fatty acid metabolic process;GO:0006694//steroid biosynthetic process;GO:0007631//feeding behavior;GO:0010740//positive regulation of intracellular protein kinase cascade;GO:0015980//energy derivation by oxidation of organic compounds;GO:0016125//sterol metabolic process;GO:0019221//cytokine-mediated signaling pathway;GO:0021953//central nervous system neuron differentiation;GO:0022602//ovulation cycle process;GO:0030073//insulin secretion;GO:0030299//intestinal cholesterol absorption;GO:0032096//negative regulation of response to food;GO:0043434//response to peptide hormone stimulus;GO:0045597//positive regulation of cell differentiation;GO:0045927//positive regulation of growth;GO:0048513//organ development gi|4557715|ref|NP_000221.1|/5.56141e-91/leptin precursor [Homo sapiens] 127254 7170 0 33 0.001 0.067693237 6.08093981 Up 5.82E-08 1.83E-07 C1orf173 4 - - - gi|282721063|ref|NP_001002912.4|/0/uncharacterized protein C1orf173 [Homo sapiens] 25966 6349 0 29 0.001 0.067180491 6.069970426 Up 4.49E-07 1.32E-06 C2CD2 2 GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part - - gi|119226222|ref|NP_056315.1|/0/C2 domain-containing protein 2 isoform 1 precursor [Homo sapiens] 284525 4427 0 19 0.001 0.06312401 5.980116949 Up 7.38E-05 0.000178216 SLC9C2 3 GO:0031224//intrinsic to membrane GO:0015078//hydrogen ion transmembrane transporter activity;GO:0015291//secondary active transmembrane transporter activity GO:0030001//metal ion transport gi|224465231|ref|NP_848622.2|/0/sodium/hydrogen exchanger 11 [Homo sapiens] 8842 4257 0 18 0.001 0.062189828 5.95860672 Up 0.000122989 0.00028919 PROM1 1 GO:0005902//microvillus;GO:0016021//integral to membrane;GO:0031513//nonmotile primary cilium;GO:0044421//extracellular region part;GO:0044459//plasma membrane part - GO:0001754//eye photoreceptor cell differentiation;GO:0003407//neural retina development;GO:0050953//sensory perception of light stimulus gi|224994189|ref|NP_001139319.1|/0/prominin-1 isoform 2 precursor [Homo sapiens]//gi|224994193|ref|NP_001139321.1|/0/prominin-1 isoform 7 precursor [Homo sapiens]//gi|224994195|ref|NP_001139322.1|/0/prominin-1 isoform 6 precursor [Homo sapiens]//gi|224994197|ref|NP_001139323.1|/0/prominin-1 isoform 5 precursor [Homo sapiens]//gi|224994199|ref|NP_001139324.1|/0/prominin-1 isoform 4 precursor [Homo sapiens]//gi|5174387|ref|NP_006008.1|/0/prominin-1 isoform 1 precursor [Homo sapiens] 6476 6023 0 25 0.001 0.061048872 5.93189274 Up 3.45E-06 9.47E-06 SI 3 GO:0031224//intrinsic to membrane;GO:0042995//cell projection;GO:0043231//intracellular membrane-bounded organelle;GO:0044459//plasma membrane part GO:0004558//alpha-glucosidase activity;GO:0005488//binding GO:0006950//response to stress;GO:0007586//digestion;GO:0009746;GO:0031960//response to corticosteroid stimulus;GO:0032502//developmental process;GO:0033273//response to vitamin;GO:0034285;GO:0043434//response to peptide hormone stimulus;GO:0044238//primary metabolic process "gi|157364974|ref|NP_001032.2|/0/sucrase-isomaltase, intestinal [Homo sapiens]" 5992 3965 0 16 0.001 0.059350898 5.891197943 Up 0.000341308 0.000761736 RFX4 1 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0007420//brain development;GO:0009653//anatomical structure morphogenesis;GO:0021510//spinal cord development "gi|148689463|gb|EDL21410.1|/0/regulatory factor X, 4 (influences HLA class II expression), isoform CRA_c [Mus musculus]//gi|19743886|ref|NP_115880.2|/0/transcription factor RFX4 isoform a [Homo sapiens]//gi|331999966|ref|NP_001193620.1|/0/transcription factor RFX4 isoform d [Homo sapiens] " 6531 3952 2 175 0.011178315 0.651285806 5.864516132 Up 5.02E-36 4.74E-35 SLC6A3 4 GO:0005624//membrane fraction;GO:0016021//integral to membrane;GO:0043005//neuron projection;GO:0044297//cell body;GO:0044424//intracellular part GO:0005328//neurotransmitter:sodium symporter activity;GO:0005515//protein binding;GO:0008504//monoamine transmembrane transporter activity;GO:0043176//amine binding GO:0007589//body fluid secretion;GO:0007606//sensory perception of chemical stimulus;GO:0007610//behavior;GO:0010038//response to metal ion;GO:0014073;GO:0021983//pituitary gland development;GO:0032102;GO:0035264//multicellular organism growth;GO:0035725//sodium ion transmembrane transport;GO:0042069//regulation of catecholamine metabolic process;GO:0042133//neurotransmitter metabolic process;GO:0042417//dopamine metabolic process;GO:0051937 gi|4507041|ref|NP_001035.1|/0/sodium-dependent dopamine transporter [Homo sapiens] 6523 5061 0 19 0.001 0.055216359 5.787023848 Up 7.38E-05 0.000178194 SLC5A1 1 GO:0005903//brush border;GO:0016021//integral to membrane;GO:0030054//cell junction GO:0005355//glucose transmembrane transporter activity;GO:0005488//binding;GO:0015291//secondary active transmembrane transporter activity GO:0001822//kidney development;GO:0015758//glucose transport;GO:0022600//digestive system process;GO:0030001//metal ion transport;GO:0044238//primary metabolic process gi|145337974|gb|AAI39840.2|/0/SLC5A1 protein [Homo sapiens] 359 4288 0 16 0.001 0.054880203 5.778213903 Up 0.000341308 0.000761825 AQP2 5 GO:0000323//lytic vacuole;GO:0005626//insoluble fraction;GO:0005768//endosome;GO:0005783//endoplasmic reticulum;GO:0012506//vesicle membrane;GO:0030133//transport vesicle;GO:0030135//coated vesicle;GO:0031224//intrinsic to membrane;GO:0032991//macromolecular complex;GO:0044431//Golgi apparatus part;GO:0044459//plasma membrane part GO:0005372//water transmembrane transporter activity;GO:0008092//cytoskeletal protein binding;GO:0015166//polyol transmembrane transporter activity;GO:0019904//protein domain specific binding GO:0001656//metanephros development;GO:0001977;GO:0002237//response to molecule of bacterial origin;GO:0006970//response to osmotic stress;GO:0008154//actin polymerization or depolymerization;GO:0008643//carbohydrate transport;GO:0009414//response to water deprivation;GO:0012501//programmed cell death;GO:0019725//cellular homeostasis;GO:0022414//reproductive process;GO:0042044//fluid transport;GO:0043270//positive regulation of ion transport;GO:0043434//response to peptide hormone stimulus;GO:0046688//response to copper ion;GO:0046689//response to mercury ion gi|4502179|ref|NP_000477.1|/9.10393e-131/aquaporin-2 [Homo sapiens] 6404 2638 4 319 0.033492571 1.778551283 5.730717634 Up 2.79E-64 4.58E-63 SELPLG 1 GO:0005626//insoluble fraction;GO:0016021//integral to membrane GO:0005515//protein binding;GO:0043498//cell surface binding GO:0002376//immune system process;GO:0007159//leukocyte cell-cell adhesion;GO:0007599//hemostasis;GO:0070741//response to interleukin-6 gi|34534636|dbj|BAC87066.1|/1.79986e-92/unnamed protein product [Homo sapiens]//gi|34534636|dbj|BAC87066.1|/1.85242e-92/unnamed protein product [Homo sapiens] 124149 6140 6 467 0.021584707 1.118662319 5.695621259 Up 2.38E-93 5.83E-92 ANKRD26P1 1 - - - gi|119603082|gb|EAW82676.1|/0/hCG1781582 [Homo sapiens] 163479 3064 9 700 0.064880925 3.360158621 5.694591131 Up 2.72E-139 1.01E-137 FNDC7 1 - - - gi|222144290|ref|NP_001138409.1|/0/fibronectin type III domain-containing protein 7 precursor [Homo sapiens] 222611 5135 0 18 0.001 0.051556397 5.688079534 Up 0.000122989 0.000289297 GPR111 6 GO:0031224//intrinsic to membrane GO:0004888//transmembrane signaling receptor activity GO:0007186//G-protein coupled receptor signaling pathway gi|134288847|ref|NP_722581.4|/0/probable G-protein coupled receptor 111 precursor [Homo sapiens] 93035 14017 0 48 0.001 0.050365908 5.654375607 Up 2.76E-11 1.08E-10 PKHD1L1 4 GO:0031224//intrinsic to membrane;GO:0044421//extracellular region part;GO:0044444//cytoplasmic part GO:0004871//signal transducer activity GO:0002376//immune system process gi|126116589|ref|NP_803875.2|/0/fibrocystin-L precursor [Homo sapiens] 79841 3613 1 75 0.006113576 0.305311949 5.642123711 Up 8.97E-16 4.39E-15 AGBL2 3 GO:0044444//cytoplasmic part GO:0008235//metalloexopeptidase activity;GO:0046914//transition metal ion binding GO:0019538//protein metabolic process gi|31657119|ref|NP_079059.2|/0/cytosolic carboxypeptidase 2 [Homo sapiens] 7058 5826 0 18 0.001 0.045441486 5.505938109 Up 0.000122989 0.000289405 THBS2 2 - GO:0005539//glycosaminoglycan binding;GO:0046872//metal ion binding GO:0009987//cellular process gi|152012473|gb|AAI50176.1|/0/Thrombospondin 2 [Homo sapiens] 6540 2226 2 136 0.019845778 0.898595519 5.500767862 Up 1.35E-27 1.02E-26 SLC6A13 2 GO:0016021//integral to membrane GO:0005283//sodium:amino acid symporter activity;GO:0005326//neurotransmitter transporter activity;GO:0005488//binding GO:0001505//regulation of neurotransmitter levels;GO:0006810//transport;GO:0006865//amino acid transport;GO:0035725//sodium ion transmembrane transport gi|21361581|ref|NP_057699.2|/0/sodium- and chloride-dependent GABA transporter 2 isoform 1 [Homo sapiens]//gi|300360519|ref|NP_001177926.1|/0/sodium- and chloride-dependent GABA transporter 2 isoform 2 [Homo sapiens] //gi|343432607|ref|NP_001230321.1|/3.58077e-53/sodium- and chloride-dependent GABA transporter 2 isoform 3 [Homo sapiens] 3596 1282 2 136 0.034459205 1.560275839 5.500767862 Up 1.35E-27 1.02E-26 IL13 2 GO:0000267//cell fraction;GO:0044421//extracellular region part GO:0005126//cytokine receptor binding GO:0001818//negative regulation of cytokine production;GO:0002237//response to molecule of bacterial origin;GO:0002377//immunoglobulin production;GO:0006952//defense response;GO:0007154//cell communication;GO:0009605//response to external stimulus;GO:0014070//response to organic cyclic compound;GO:0015992//proton transport;GO:0023052//signaling;GO:0030888//regulation of B cell proliferation;GO:0048522//positive regulation of cellular process gi|116138167|gb|AAH96141.2|/2.67936e-73/Interleukin 13 [Homo sapiens] 4585 16819 0 51 0.001 0.044598526 5.478924126 Up 5.97E-12 2.40E-11 MUC4 4 GO:0016021//integral to membrane;GO:0031012//extracellular matrix GO:0005102//receptor binding;GO:0005201//extracellular matrix structural constituent GO:0031589//cell-substrate adhesion gi|112382231|ref|NP_612154.2|/0/mucin-4 isoform e precursor [Homo sapiens]//gi|112382233|ref|NP_004523.3|/0/mucin-4 isoform d precursor [Homo sapiens]//gi|257471027|ref|NP_060876.5|/0/mucin-4 isoform a precursor [Homo sapiens] 128346 946 5 319 0.116746039 4.959638778 5.408789539 Up 7.28E-63 1.17E-61 C1orf162 2 GO:0031224//intrinsic to membrane - - gi|28827822|ref|NP_777556.1|/5.68175e-69/transmembrane protein C1orf162 [Homo sapiens] 3818 2252 2 126 0.019616652 0.822910605 5.390584944 Up 1.92E-25 1.35E-24 KLKB1 3 GO:0016020//membrane;GO:0044421//extracellular region part;GO:0044424//intracellular part GO:0004175//endopeptidase activity GO:0002353//plasma kallikrein-kinin cascade;GO:0030195//negative regulation of blood coagulation;GO:0031638//zymogen activation gi|78191798|ref|NP_000883.2|/0/plasma kallikrein preproprotein [Homo sapiens] 5175 6831 1 60 0.003233546 0.129186599 5.320195616 Up 1.53E-12 6.38E-12 PECAM1 4 GO:0030667//secretory granule membrane;GO:0031224//intrinsic to membrane;GO:0044421//extracellular region part;GO:0044459//plasma membrane part GO:0005488//binding GO:0001775//cell activation;GO:0006887//exocytosis;GO:0006897//endocytosis;GO:0007599//hemostasis;GO:0023052//signaling;GO:0050900//leukocyte migration gi|313760624|ref|NP_000433.4|/0/platelet endothelial cell adhesion molecule precursor [Homo sapiens] 58538 2475 1 59 0.008924586 0.35061243 5.29594807 Up 2.51E-12 1.03E-11 MPP4 2 GO:0044424//intracellular part GO:0005488//binding - gi|14780902|ref|NP_149055.1|/0/MAGUK p55 subfamily member 4 [Homo sapiens] 4049 1474 2 118 0.029970625 1.177429802 5.29594807 Up 1.00E-23 6.65E-23 LTA 3 GO:0044421//extracellular region part;GO:0044464//cell part GO:0032813//tumor necrosis factor receptor superfamily binding GO:0001819//positive regulation of cytokine production;GO:0002237//response to molecule of bacterial origin;GO:0002439//chronic inflammatory response to antigenic stimulus;GO:0002455//humoral immune response mediated by circulating immunoglobulin;GO:0007154//cell communication;GO:0008285//negative regulation of cell proliferation;GO:0012502//induction of programmed cell death;GO:0023052//signaling;GO:0031667//response to nutrient levels;GO:0042742//defense response to bacterium;GO:0044126;GO:0048534 gi|6806893|ref|NP_000586.2|/2.60554e-96/lymphotoxin-alpha precursor [Homo sapiens]//gi|6806893|ref|NP_000586.2|/2.71857e-96/lymphotoxin-alpha precursor [Homo sapiens] 126017 4188 2 116 0.0105484 0.407381982 5.271286016 Up 2.69E-23 1.75E-22 ZNF813 3 - GO:0005488//binding - gi|108796666|ref|NP_001004301.2|/0/zinc finger protein 813 [Homo sapiens] 140691 1911 2 112 0.02311706 0.862001132 5.220659942 Up 1.94E-22 1.23E-21 TRIM69 3 GO:0016604//nuclear body GO:0046914//transition metal ion binding GO:0012501//programmed cell death gi|37595541|ref|NP_542783.2|/0/tripartite motif-containing protein 69 isoform b [Homo sapiens]//gi|88999601|ref|NP_892030.3|/0/tripartite motif-containing protein 69 isoform a [Homo sapiens] 401127 1651 2 110 0.026757542 0.979932389 5.194664734 Up 5.19E-22 3.24E-21 LOC401127 1 GO:0000123//histone acetyltransferase complex;GO:0016585//chromatin remodeling complex;GO:0035097//histone methyltransferase complex GO:0005488//binding;GO:0018024//histone-lysine N-methyltransferase activity GO:0016573//histone acetylation;GO:0034968//histone lysine methylation "gi|112491198|pdb|2H9L|A/5.74263e-82/Chain A, Wdr5delta23" 1141 5731 5 274 0.019270939 0.703186711 5.189409008 Up 3.25E-53 4.43E-52 CHRNB2 2 GO:0005626//insoluble fraction;GO:0005887//integral to plasma membrane;GO:0009986//cell surface GO:0004888//transmembrane signaling receptor activity;GO:0005231//excitatory extracellular ligand-gated ion channel activity;GO:0042165//neurotransmitter binding "GO:0001508//regulation of action potential;GO:0001963//synaptic transmission, dopaminergic;GO:0006936//muscle contraction;GO:0006950//response to stress;GO:0007274//neuromuscular synaptic transmission;GO:0007612//learning;GO:0007631//feeding behavior;GO:0007632//visual behavior;GO:0010646//regulation of cell communication;GO:0010769//regulation of cell morphogenesis involved in differentiation;GO:0014046;GO:0014073;GO:0021554//optic nerve development;GO:0021794//thalamus development;GO:0021955//central nervous system neuron axonogenesis;GO:0030534//adult behavior;GO:0030888//regulation of B cell proliferation;GO:0042069//regulation of catecholamine metabolic process;GO:0042747//circadian sleep/wake cycle, REM sleep;GO:0044087;GO:0045187//regulation of circadian sleep/wake cycle, sleep;GO:0050953//sensory perception of light stimulus;GO:0050954//sensory perception of mechanical stimulus;GO:0051259//protein oligomerization;GO:0051705;GO:0070838//divalent metal ion transport" gi|4502833|ref|NP_000739.1|/0/neuronal acetylcholine receptor subunit beta-2 precursor [Homo sapiens] 768206 2081 1 53 0.010614296 0.37458837 5.141225475 Up 4.86E-11 1.87E-10 PRCD 2 GO:0031224//intrinsic to membrane;GO:0044424//intracellular part - GO:0050953//sensory perception of light stimulus "gi|119609818|gb|EAW89412.1|/6.14486e-28/hCG1821181, isoform CRA_d [Homo sapiens]//gi|119609818|gb|EAW89412.1|/6.38738e-28/hCG1821181, isoform CRA_d [Homo sapiens]" 7038 8453 2 104 0.005226157 0.180955993 5.113744739 Up 9.96E-21 5.95E-20 TG 4 GO:0043231//intracellular membrane-bounded organelle;GO:0044421//extracellular region part;GO:0044444//cytoplasmic part GO:0005102//receptor binding GO:0002237//response to molecule of bacterial origin;GO:0006575//cellular modified amino acid metabolic process;GO:0009058//biosynthetic process;GO:0009628//response to abiotic stimulus;GO:0015698//inorganic anion transport;GO:0016192//vesicle-mediated transport;GO:0042552//myelination gi|55770862|ref|NP_003226.4|/0/thyroglobulin precursor [Homo sapiens] 270 2426 2 103 0.018209687 0.624448934 5.099805548 Up 1.63E-20 9.64E-20 AMPD1 2 GO:0044444//cytoplasmic part "GO:0016814//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines;GO:0043169//cation binding" GO:0009112;GO:0009127//purine nucleoside monophosphate biosynthetic process;GO:0042221//response to chemical stimulus gi|289547498|ref|NP_001166097.1|/0/AMP deaminase 1 isoform 2 [Homo sapiens]//gi|289547500|ref|NP_000027.2|/0/AMP deaminase 1 isoform 1 [Homo sapiens] 220115 2627 2 100 0.016816407 0.559874165 5.05716121 Up 7.11E-20 4.09E-19 TPTE2P3 1 GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle GO:0004721//phosphoprotein phosphatase activity;GO:0015075//ion transmembrane transporter activity;GO:0034594//phosphatidylinositol trisphosphate phosphatase activity GO:0006464//cellular protein modification process;GO:0006810//transport;GO:0023052//signaling "gi|119628627|gb|EAX08222.1|/0/transmembrane phosphoinositide 3-phosphatase and tensin homolog 2, isoform CRA_d [Homo sapiens]" 100329135 2835 2 99 0.015582611 0.513609008 5.04266164 Up 1.16E-19 6.64E-19 TRPC5OS 1 - - - gi|307133679|ref|NP_001182505.1|/1.12686e-38/uncharacterized protein LOC100288395 [Homo sapiens]//gi|307133679|ref|NP_001182505.1|/1.14848e-38/uncharacterized protein LOC100288395 [Homo sapiens]//gi|307133679|ref|NP_001182505.1|/1.15856e-38/uncharacterized protein LOC100288395 [Homo sapiens] 147741 2802 2 98 0.015766132 0.514408866 5.028014864 Up 1.90E-19 1.08E-18 ZNF560 2 GO:0005622//intracellular GO:0003676//nucleic acid binding;GO:0046872//metal ion binding - gi|124517687|ref|NP_689689.2|/0/zinc finger protein 560 [Homo sapiens] 3196 2170 2 93 0.020357927 0.630338327 4.952463831 Up 2.20E-18 1.20E-17 TLX2 4 GO:0044424//intracellular part GO:0005488//binding GO:0009653//anatomical structure morphogenesis;GO:0048731;GO:0050794//regulation of cellular process gi|326205295|dbj|BAJ84026.1|/8.07956e-90/T-cell leukemia homeobox protein 2 [Homo sapiens] 79679 2742 2 90 0.016111124 0.482753642 4.905158117 Up 9.56E-18 5.08E-17 VTCN1 1 GO:0031224//intrinsic to membrane - - gi|55959603|emb|CAI12737.1|/3.46436e-44/V-set domain containing T cell activation inhibitor 1 [Homo sapiens]//gi|55959603|emb|CAI12737.1|/3.58401e-138/V-set domain containing T cell activation inhibitor 1 [Homo sapiens]//gi|55959603|emb|CAI12737.1|/8.42313e-69/V-set domain containing T cell activation inhibitor 1 [Homo sapiens]//gi|55959603|emb|CAI12737.1|/8.56377e-140/V-set domain containing T cell activation inhibitor 1 [Homo sapiens]//gi|99028881|ref|NP_078902.2|/4.08521e-139/V-set domain-containing T-cell activation inhibitor 1 isoform 1 precursor [Homo sapiens] 374897 1998 4 176 0.044220922 1.295590289 4.872736639 Up 1.34E-33 1.19E-32 SBSN 1 GO:0044424//intracellular part - - gi|260436922|ref|NP_001159506.1|/0/suprabasin isoform 1 precursor [Homo sapiens]//gi|260447062|ref|NP_001159507.1|/5.19482e-63/suprabasin isoform 3 precursor [Homo sapiens]//gi|38348366|ref|NP_940940.1|/5.18747e-105/suprabasin isoform 2 precursor [Homo sapiens] 79098 5502 10 438 0.040146039 1.170857453 4.866163985 Up 8.96E-82 1.91E-80 C1orf116 1 GO:0016020//membrane;GO:0044424//intracellular part GO:0004871//signal transducer activity - gi|145275189|ref|NP_076427.2|/0/specifically androgen-regulated gene protein isoform 1 [Homo sapiens] 9514 1791 3 130 0.036998912 1.067574684 4.850710333 Up 4.78E-25 3.32E-24 GAL3ST1 1 GO:0005626//insoluble fraction;GO:0012505//endomembrane system;GO:0016021//integral to membrane;GO:0043231//intracellular membrane-bounded organelle GO:0050694//galactose 3-O-sulfotransferase activity GO:0006486//protein glycosylation;GO:0006681//galactosylceramide metabolic process;GO:0008366//axon ensheathment;GO:0048232//male gamete generation gi|4758088|ref|NP_004852.1|/0/galactosylceramide sulfotransferase [Homo sapiens] 9256 7698 2 84 0.005738725 0.160491442 4.805622443 Up 1.79E-16 9.01E-16 BZRAP1 1 GO:0043231//intracellular membrane-bounded organelle GO:0005102//receptor binding - gi|171906559|ref|NP_004749.2|/0/peripheral-type benzodiazepine receptor-associated protein 1 isoform a [Homo sapiens]//gi|34327964|dbj|BAA31587.2|/0/KIAA0612 protein [Homo sapiens]//gi|387912548|ref|NP_001248764.1|/0/peripheral-type benzodiazepine receptor-associated protein 1 isoform c [Homo sapiens] 285800 2704 2 83 0.016337537 0.451462732 4.788344452 Up 2.92E-16 1.46E-15 PRR18 3 - - - gi|58331144|ref|NP_787118.2|/1.78436e-81/proline-rich protein 18 [Homo sapiens] 3938 6274 4 164 0.014082468 0.384458825 4.770857025 Up 4.67E-31 3.86E-30 LCT 2 GO:0005626//insoluble fraction;GO:0016021//integral to membrane;GO:0042995//cell projection;GO:0044459//plasma membrane part "GO:0004553//hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0043167//ion binding" GO:0006950//response to stress;GO:0007586//digestion;GO:0010038//response to metal ion;GO:0031667//response to nutrient levels;GO:0034285;GO:0044238//primary metabolic process;GO:0048545//response to steroid hormone stimulus gi|32481206|ref|NP_002290.2|/0/lactase-phlorizin hydrolase preproprotein [Homo sapiens] 5649 11571 0 20 0.001 0.025421993 4.668005257 Up 4.43E-05 0.00010952 RELN 3 GO:0031012//extracellular matrix;GO:0043005//neuron projection;GO:0044424//intracellular part "GO:0004672//protein kinase activity;GO:0043169//cation binding;GO:0070011//peptidase activity, acting on L-amino acid peptides" GO:0000902//cell morphogenesis;GO:0003002//regionalization;GO:0006468//protein phosphorylation;GO:0006935//chemotaxis;GO:0007610//behavior;GO:0009967//positive regulation of signal transduction;GO:0021795//cerebral cortex cell migration;GO:0030154//cell differentiation;GO:0033555//multicellular organismal response to stress;GO:0033674//positive regulation of kinase activity gi|27436938|ref|NP_005036.2|/0/reelin isoform a precursor [Homo sapiens]//gi|27436940|ref|NP_774959.1|/0/reelin isoform b precursor [Homo sapiens] 80736 2646 2 75 0.016695654 0.416890428 4.642123711 Up 1.43E-14 6.57E-14 SLC44A4 1 GO:0031224//intrinsic to membrane GO:0005275//amine transmembrane transporter activity GO:0015697//quaternary ammonium group transport gi|148612887|ref|NP_079533.2|/0/choline transporter-like protein 4 isoform 1 [Homo sapiens]//gi|295849282|ref|NP_001171515.1|/0/choline transporter-like protein 4 isoform 2 [Homo sapiens] 1436 4006 2 73 0.011027634 0.268017046 4.603129579 Up 3.76E-14 1.70E-13 CSF1R 3 GO:0016021//integral to membrane;GO:0043234//protein complex GO:0004714//transmembrane receptor protein tyrosine kinase activity;GO:0032559;GO:0042802//identical protein binding GO:0006464//cellular protein modification process;GO:0007167//enzyme linked receptor protein signaling pathway;GO:0032501//multicellular organismal process gi|27262659|ref|NP_005202.2|/0/macrophage colony-stimulating factor 1 receptor precursor [Homo sapiens] 10350 6310 3 108 0.010501593 0.25173575 4.583230022 Up 2.10E-20 1.24E-19 ABCA9 3 GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle GO:0017111//nucleoside-triphosphatase activity;GO:0032559 GO:0009207;GO:0051234//establishment of localization gi|27477115|ref|NP_525022.2|/0/ATP-binding cassette sub-family A member 9 [Homo sapiens] 116285 2051 2 71 0.021539103 0.509146999 4.56305214 Up 9.90E-14 4.39E-13 ACSM1 2 GO:0044429//mitochondrial part GO:0016405//CoA-ligase activity;GO:0016878//acid-thiol ligase activity;GO:0032559;GO:0032561//guanyl ribonucleotide binding;GO:0043169//cation binding GO:0006091//generation of precursor metabolites and energy;GO:0046459//short-chain fatty acid metabolic process "gi|115511026|ref|NP_443188.2|/0/acyl-coenzyme A synthetase ACSM1, mitochondrial [Homo sapiens]" 649395 1828 2 69 0.024166686 0.555166689 4.521829477 Up 2.60E-13 1.13E-12 LOC649395 1 GO:0005875//microtubule associated complex;GO:0030424//axon;GO:0048770 GO:0016491//oxidoreductase activity;GO:0016597//amino acid binding;GO:0019899//enzyme binding;GO:0030291//protein serine/threonine kinase inhibitor activity GO:0006470//protein dephosphorylation;GO:0006886//intracellular protein transport;GO:0006917//induction of apoptosis;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0016477//cell migration;GO:0021543//pallium development;GO:0022402//cell cycle process;GO:0051704 gi|5803225|ref|NP_006752.1|/2.04055e-105/14-3-3 protein epsilon [Homo sapiens] 200232 689 1 34 0.032058564 0.725788689 4.500767862 Up 5.24E-07 1.53E-06 FAM209A 3 GO:0031224//intrinsic to membrane - - "gi|119595942|gb|EAW75536.1|/1.33302e-91/hCG2018184, isoform CRA_a [Homo sapiens]" 5345 2296 2 68 0.019240724 0.435599657 4.500767862 Up 4.22E-13 1.81E-12 SERPINF2 1 GO:0031091//platelet alpha granule;GO:0044421//extracellular region part GO:0004866//endopeptidase inhibitor activity;GO:0019899//enzyme binding GO:0001775//cell activation;GO:0002526//acute inflammatory response;GO:0006508//proteolysis;GO:0006887//exocytosis;GO:0010466//negative regulation of peptidase activity;GO:0030194//positive regulation of blood coagulation;GO:0030195//negative regulation of blood coagulation;GO:0042221//response to chemical stimulus "gi|119610986|gb|EAW90580.1|/0/serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2, isoform CRA_c [Homo sapiens]//gi|260064050|ref|NP_001159393.1|/0/alpha-2-antiplasmin isoform b precursor [Homo sapiens] " 1558 2024 2 67 0.021826433 0.486871995 4.479394211 Up 6.84E-13 2.90E-12 CYP2C8 3 GO:0031090//organelle membrane;GO:0042598;GO:0043231//intracellular membrane-bounded organelle "GO:0005506//iron ion binding;GO:0016712//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0033695" GO:0042493//response to drug;GO:0044237//cellular metabolic process;GO:0055114//oxidation-reduction process "gi|311893311|ref|NP_001185783.1|/0/cytochrome P450 2C8 isoform c [Homo sapiens] //gi|42543301|pdb|1PQ2|A/0/Chain A, Crystal Structure Of Human Drug Metabolizing Cytochrome P450 2c8//gi|98991773|ref|NP_000761.3|/0/cytochrome P450 2C8 isoform a precursor [Homo sapiens]" 5837 3633 54 1797 0.328315699 7.275003047 4.469792212 Up 0 0 PYGM 2 GO:0000267//cell fraction;GO:0005783//endoplasmic reticulum GO:0004645//phosphorylase activity;GO:0030246//carbohydrate binding;GO:0032559;GO:0048037//cofactor binding GO:0005977//glycogen metabolic process;GO:0006875//cellular metal ion homeostasis;GO:0006950//response to stress;GO:0010033//response to organic substance;GO:0019318//hexose metabolic process "gi|257900462|ref|NP_001158188.1|/0/glycogen phosphorylase, muscle form isoform 2 [Homo sapiens]//gi|5032009|ref|NP_005600.1|/0/glycogen phosphorylase, muscle form isoform 1 [Homo sapiens]" 29114 1503 2 65 0.029392349 0.636069947 4.435672833 Up 1.79E-12 7.43E-12 TAGLN3 1 - - GO:0007399//nervous system development;GO:0048513//organ development gi|6563190|gb|AAF17189.1|AF112201_1/4.57831e-158/neuronal protein NP25 [Homo sapiens]//gi|6563190|gb|AAF17189.1|AF112201_1/5.202e-158/neuronal protein NP25 [Homo sapiens]//gi|6563190|gb|AAF17189.1|AF112201_1/6.13963e-158/neuronal protein NP25 [Homo sapiens] 148741 3363 2 65 0.013136099 0.284273901 4.435672833 Up 1.79E-12 7.43E-12 ANKRD35 3 - - - gi|121582655|ref|NP_653299.3|/0/ankyrin repeat domain-containing protein 35 [Homo sapiens] 4336 3077 2 65 0.014357069 0.3106965 4.435672833 Up 1.79E-12 7.42E-12 MOBP 2 GO:0000267//cell fraction;GO:0031981//nuclear lumen;GO:0044444//cytoplasmic part GO:0005198//structural molecule activity GO:0048731 "gi|119584996|gb|EAW64592.1|/4.73016e-34/myelin-associated oligodendrocyte basic protein, isoform CRA_c [Homo sapiens]//gi|119584996|gb|EAW64592.1|/5.51147e-34/myelin-associated oligodendrocyte basic protein, isoform CRA_c [Homo sapiens]" 6401 3875 2 65 0.011400439 0.246713066 4.435672833 Up 1.79E-12 7.42E-12 SELE 2 GO:0005856//cytoskeleton;GO:0012505//endomembrane system;GO:0031224//intrinsic to membrane;GO:0044421//extracellular region part;GO:0044444//cytoplasmic part;GO:0044459//plasma membrane part GO:0004872//receptor activity;GO:0019899//enzyme binding;GO:0048029//monosaccharide binding GO:0002090//regulation of receptor internalization;GO:0002237//response to molecule of bacterial origin;GO:0002684//positive regulation of immune system process;GO:0006954//inflammatory response;GO:0007159//leukocyte cell-cell adhesion;GO:0010863//positive regulation of phospholipase C activity;GO:0019932//second-messenger-mediated signaling;GO:0031347//regulation of defense response;GO:0034097//response to cytokine stimulus gi|187960042|ref|NP_000441.2|/0/E-selectin precursor [Homo sapiens] 253039 3806 4 127 0.023214241 0.490778396 4.401989707 Up 2.76E-23 1.79E-22 LOC253039 1 - - - gi|119607880|gb|EAW87474.1|/1.81973e-58/hCG2042142 [Homo sapiens] 1999 3263 6 190 0.040616029 0.856420447 4.398198128 Up 2.99E-34 2.69E-33 ELF3 1 GO:0031981//nuclear lumen GO:0001071//nucleic acid binding transcription factor activity;GO:0003677//DNA binding;GO:0003712//transcription cofactor activity GO:0001701//in utero embryonic development;GO:0006952//defense response;GO:0009888//tissue development;GO:0030154//cell differentiation;GO:0043062//extracellular structure organization;GO:0048771//tissue remodeling gi|48146329|emb|CAG33387.1|/0/ELF3 [Homo sapiens] 54854 2011 7 220 0.076886352 1.60901877 4.387309812 Up 2.06E-39 2.13E-38 FAM83E 3 - - - gi|153251792|ref|NP_060178.2|/0/protein FAM83E [Homo sapiens] 2998 3132 6 188 0.042314848 0.882849339 4.382931371 Up 7.79E-34 6.98E-33 GYS2 3 GO:0000267//cell fraction;GO:0015629//actin cytoskeleton;GO:0044444//cytoplasmic part GO:0035251//UDP-glucosyltransferase activity;GO:0042802//identical protein binding;GO:0048029//monosaccharide binding GO:0005977//glycogen metabolic process;GO:0009746;GO:0019318//hexose metabolic process "gi|119372286|ref|NP_068776.2|/0/glycogen [starch] synthase, liver [Homo sapiens]" 51285 2603 2 60 0.016971456 0.339021767 4.320195616 Up 1.98E-11 7.78E-11 RASL12 2 GO:0044464//cell part GO:0017111//nucleoside-triphosphatase activity;GO:0032561//guanyl ribonucleotide binding GO:0009207;GO:0035556//intracellular signal transduction gi|7706095|ref|NP_057647.1|/1.16142e-138/ras-like protein family member 12 [Homo sapiens] 57402 1075 2 58 0.041094606 0.793542204 4.271286016 Up 5.15E-11 1.98E-10 S100A14 2 GO:0005856//cytoskeleton;GO:0044444//cytoplasmic part;GO:0044459//plasma membrane part GO:0001664//G-protein coupled receptor binding;GO:0046872//metal ion binding GO:0002224//toll-like receptor signaling pathway;GO:0002237//response to molecule of bacterial origin;GO:0002548//monocyte chemotaxis;GO:0002690//positive regulation of leukocyte chemotaxis;GO:0055065//metal ion homeostasis gi|10190712|ref|NP_065723.1|/1.83027e-53/protein S100-A14 [Homo sapiens] 6286 510 1 29 0.043310491 0.836331245 4.271286016 Up 5.83E-06 1.56E-05 S100P 2 GO:0043231//intracellular membrane-bounded organelle GO:0005515//protein binding;GO:0046872//metal ion binding GO:0016477//cell migration gi|5174663|ref|NP_005971.1|/6.5748e-33/protein S100-P [Homo sapiens] 1995 4682 2 58 0.009435434 0.18219946 4.271286016 Up 5.15E-11 1.98E-10 ELAVL3 3 - GO:0003723//RNA binding GO:0048731;GO:0048869//cellular developmental process gi|49355761|ref|NP_001411.2|/2.35496e-180/ELAV-like protein 3 isoform 1 [Homo sapiens]//gi|49355765|ref|NP_115657.2|/9.2148e-177/ELAV-like protein 3 isoform 2 [Homo sapiens] 146225 1073 2 57 0.041171203 0.78131405 4.246195035 Up 8.31E-11 3.14E-10 CMTM2 1 GO:0031224//intrinsic to membrane;GO:0044421//extracellular region part GO:0005102//receptor binding GO:0042221//response to chemical stimulus gi|21389567|ref|NP_653274.1|/1.93742e-87/CKLF-like MARVEL transmembrane domain-containing protein 2 isoform 1 [Homo sapiens]//gi|313569848|ref|NP_001186246.1|/1.60846e-65/CKLF-like MARVEL transmembrane domain-containing protein 2 isoform 2 [Homo sapiens] 26191 3672 2 57 0.012030692 0.228308817 4.246195035 Up 8.31E-11 3.14E-10 PTPN22 1 GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part;GO:0044459//plasma membrane part GO:0004721//phosphoprotein phosphatase activity;GO:0019899//enzyme binding;GO:0019904//protein domain specific binding GO:0001787//natural killer cell proliferation;GO:0006464//cellular protein modification process;GO:0016311//dephosphorylation;GO:0030098//lymphocyte differentiation;GO:0031347//regulation of defense response;GO:0050856//regulation of T cell receptor signaling pathway;GO:0050863//regulation of T cell activation gi|224586929|ref|NP_057051.3|/0/tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens]//gi|301171662|ref|NP_036543.4|/0/tyrosine-protein phosphatase non-receptor type 22 isoform 2 [Homo sapiens]//gi|301171669|ref|NP_001180360.1|/0/tyrosine-protein phosphatase non-receptor type 22 isoform 3 [Homo sapiens] 285643 4426 2 56 0.00998118 0.186091749 4.220659942 Up 1.34E-10 5.00E-10 KIF4B 1 GO:0005819//spindle;GO:0034399//nuclear periphery;GO:0044444//cytoplasmic part GO:0003676//nucleic acid binding;GO:0003774//motor activity;GO:0032559 GO:0006935//chemotaxis;GO:0007599//hemostasis;GO:0008088//axon cargo transport;GO:0071842 gi|150010604|ref|NP_001092763.1|/0/chromosome-associated kinesin KIF4B [Homo sapiens] 1520 4107 2 56 0.010756441 0.200545917 4.220659942 Up 1.34E-10 4.99E-10 CTSS 1 GO:0000323//lytic vacuole GO:0004175//endopeptidase activity GO:0002376//immune system process;GO:0019538//protein metabolic process gi|23110962|ref|NP_004070.3|/0/cathepsin S isoform 1 preproprotein [Homo sapiens]//gi|315075311|ref|NP_001186668.1|/3.84872e-160/cathepsin S isoform 2 preproprotein [Homo sapiens] 54777 8293 1 28 0.002663493 0.049658874 4.220659942 Up 9.41E-06 2.47E-05 TTC40 2 - - - gi|359385708|ref|NP_001186978.2|/0/tetratricopeptide repeat protein 40 [Homo sapiens] 100288801 2069 6 166 0.064055149 1.180043719 4.203381951 Up 2.85E-29 2.25E-28 FRG2C 1 GO:0043231//intracellular membrane-bounded organelle - - gi|185136049|ref|NP_001118231.1|/1.14968e-162/protein FRG2-like-2 [Homo sapiens] 8399 1020 2 55 0.043310491 0.793072732 4.194664734 Up 2.16E-10 7.93E-10 PLA2G10 1 - GO:0004091//carboxylesterase activity;GO:0046872//metal ion binding GO:0000038//very long-chain fatty acid metabolic process;GO:0002694;GO:0006935//chemotaxis;GO:0010742//macrophage derived foam cell differentiation;GO:0010883//regulation of lipid storage;GO:0015914//phospholipid transport;GO:0019637//organophosphate metabolic process;GO:0031325//positive regulation of cellular metabolic process;GO:0032305//positive regulation of icosanoid secretion gi|4505845|ref|NP_003552.1|/7.74954e-83/group 10 secretory phospholipase A2 precursor [Homo sapiens] 5711 3504 5 137 0.031518765 0.575051804 4.189409008 Up 2.59E-24 1.76E-23 PSMD5 1 GO:0005838//proteasome regulatory particle GO:0005488//binding "GO:0006520//cellular amino acid metabolic process;GO:0006915//apoptotic process;GO:0007050//cell cycle arrest;GO:0016070//RNA metabolic process;GO:0030330//DNA damage response, signal transduction by p53 class mediator;GO:0043161//proteasomal ubiquitin-dependent protein catabolic process;GO:0043248//proteasome assembly;GO:0051320//S phase;GO:0051439//regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle" gi|394025672|ref|NP_001257356.1|/0/26S proteasome non-ATPase regulatory subunit 5 isoform 2 [Homo sapiens] //gi|505106|dbj|BAA06687.1|/0/KIAA0072 [Homo sapiens] 284186 3335 1 27 0.006623194 0.119074407 4.168192523 Up 1.52E-05 3.91E-05 TMEM105 3 GO:0031224//intrinsic to membrane - - gi|119610053|gb|EAW89647.1|/1.55855e-90/transmembrane protein 105 [Homo sapiens] 6866 958 3 80 0.0691702 1.228216644 4.150270615 Up 1.43E-14 6.60E-14 TAC3 1 GO:0000267//cell fraction;GO:0044421//extracellular region part GO:0005515//protein binding GO:0007186//G-protein coupled receptor signaling pathway;GO:0008217//regulation of blood pressure;GO:0014072;GO:0022414//reproductive process gi|295849290|ref|NP_001171525.1|/1.01588e-51/tachykinin-3 isoform 2 preproprotein [Homo sapiens]//gi|33331094|gb|AAQ10783.1|/6.16941e-71/alpha tachykinin 3 precursor variant 1 [Homo sapiens]//gi|7019577|ref|NP_037383.1|/1.1016e-62/tachykinin-3 isoform 1 preproprotein [Homo sapiens] 57010 4036 2 52 0.010945664 0.189497152 4.113744739 Up 8.98E-10 3.19E-09 CABP4 3 GO:0033267//axon part;GO:0044424//intracellular part GO:0046872//metal ion binding GO:0007165//signal transduction;GO:0042462//eye photoreceptor cell development;GO:0050953//sensory perception of light stimulus gi|355566246|gb|EHH22625.1|/3.69604e-142/Calcium-binding protein 4 [Macaca mulatta] 339302 1980 2 52 0.022311465 0.386267931 4.113744739 Up 8.98E-10 3.19E-09 CPLX4 3 GO:0044459//plasma membrane part GO:0000149//SNARE binding GO:0016192//vesicle-mediated transport;GO:0050804//regulation of synaptic transmission gi|31795561|ref|NP_857637.1|/6.16725e-65/complexin-4 [Homo sapiens] 2487 2775 4 100 0.031839064 0.530014209 4.05716121 Up 1.07E-17 5.65E-17 FRZB 3 GO:0044421//extracellular region part;GO:0044424//intracellular part GO:0004888//transmembrane signaling receptor activity;GO:0019904//protein domain specific binding GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0006915//apoptotic process;GO:0007417//central nervous system development;GO:0008283//cell proliferation;GO:0016049//cell growth;GO:0030178//negative regulation of Wnt receptor signaling pathway;GO:0042472//inner ear morphogenesis;GO:0045137//development of primary sexual characteristics;GO:0045596//negative regulation of cell differentiation;GO:0045597//positive regulation of cell differentiation;GO:0048771//tissue remodeling;GO:0060026//convergent extension gi|38455388|ref|NP_001454.2|/5.57077e-171/secreted frizzled-related protein 3 precursor [Homo sapiens] 57111 1101 2 50 0.040124161 0.667933438 4.05716121 Up 2.32E-09 8.04E-09 RAB25 2 GO:0016020//membrane;GO:0031143//pseudopodium;GO:0031410//cytoplasmic vesicle GO:0005515//protein binding;GO:0032561//guanyl ribonucleotide binding GO:0006810//transport;GO:0008283//cell proliferation;GO:0030030//cell projection organization;GO:0035556//intracellular signal transduction gi|9789019|gb|AAF98238.1|/6.1569e-121/unknown [Homo sapiens] 342096 3176 2 50 0.013909541 0.231547454 4.05716121 Up 2.32E-09 8.03E-09 GOLGA6A 2 - - - gi|146133848|ref|NP_001033729.2|/0/Golgin subfamily A member 6A [Homo sapiens] 91977 3841 4 98 0.023002708 0.375259995 4.028014864 Up 2.74E-17 1.43E-16 MYOZ3 4 GO:0031674//I band GO:0005488//binding - gi|171184445|ref|NP_588612.2|/1.62493e-130/myozenin-3 [Homo sapiens]//gi|171184445|ref|NP_588612.2|/1.80116e-130/myozenin-3 [Homo sapiens] 128025 4371 1 23 0.005053386 0.07739226 3.936866976 Up 0.000101552 0.000241045 WDR64 4 - - - gi|268370094|ref|NP_653226.4|/0/WD repeat-containing protein 64 [Homo sapiens] 7123 886 1 23 0.024930418 0.38180764 3.936866976 Up 0.000101552 0.000241105 CLEC3B 2 GO:0044421//extracellular region part GO:0030246//carbohydrate binding;GO:0046872//metal ion binding GO:0048731 gi|156627579|ref|NP_003269.2|/4.71983e-115/tetranectin precursor [Homo sapiens] 643832 549 1 23 0.04023379 0.616177721 3.936866976 Up 0.000101552 0.000241075 GAGE10 2 - GO:0005488//binding GO:0006952//defense response gi|150010546|ref|NP_001091883.2|/9.98435e-55/G antigen 10 [Homo sapiens] 10888 4300 11 250 0.056505083 0.855110134 3.919657686 Up 1.68E-41 1.80E-40 GPR83 3 GO:0031224//intrinsic to membrane GO:0008188//neuropeptide receptor activity GO:0007166//cell surface receptor signaling pathway;GO:0031960//response to corticosteroid stimulus gi|223633971|ref|NP_057624.3|/0/probable G-protein coupled receptor 83 precursor [Homo sapiens] 570 3478 14 317 0.08891228 1.340541258 3.914289128 Up 3.22E-52 4.31E-51 BAAT 1 GO:0044439 - GO:0006694//steroid biosynthetic process;GO:0006732//coenzyme metabolic process;GO:0009069//serine family amino acid metabolic process;GO:0009887//organ morphogenesis;GO:0015718//monocarboxylic acid transport;GO:0032787//monocarboxylic acid metabolic process gi|4502351|ref|NP_001692.1|/0/bile acid-CoA:amino acid N-acyltransferase [Homo sapiens] 5148 1064 8 180 0.166077824 2.488177608 3.905158117 Up 3.70E-30 3.00E-29 PDE6G 3 GO:0044444//cytoplasmic part "GO:0004112//cyclic-nucleotide phosphodiesterase activity;GO:0004114//3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0019002//GMP binding;GO:0030234//enzyme regulator activity" GO:0000165//MAPK cascade;GO:0001775//cell activation;GO:0007599//hemostasis;GO:0008277//regulation of G-protein coupled receptor protein signaling pathway;GO:0009967//positive regulation of signal transduction;GO:0050953//sensory perception of light stimulus "gi|119610072|gb|EAW89666.1|/2.86312e-75/phosphodiesterase 6G, cGMP-specific, rod, gamma [Homo sapiens] //gi|332849303|ref|XP_001154701.2|/8.04722e-16/PREDICTED: hypothetical protein LOC746726 [Pan troglodytes]" 554 1788 4 90 0.049414655 0.74033025 3.905158117 Up 1.18E-15 5.72E-15 AVPR2 1 GO:0016021//integral to membrane;GO:0043231//intracellular membrane-bounded organelle GO:0008528//G-protein coupled peptide receptor activity "GO:0001816//cytokine production;GO:0003073//regulation of systemic arterial blood pressure;GO:0007187//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007243//intracellular protein kinase cascade;GO:0008283//cell proliferation;GO:0010033//response to organic substance;GO:0010467//gene expression;GO:0030900//forebrain development;GO:0042044//fluid transport;GO:0045762//positive regulation of adenylate cyclase activity" gi|447224|prf||1913493A/9.23424e-88/vasopressin receptor:ISOTYPE=V2//gi|4557345|ref|NP_000045.1|/2.5115e-167/vasopressin V2 receptor isoform 1 [Homo sapiens]//gi|4557345|ref|NP_000045.1|/5.56638e-173/vasopressin V2 receptor isoform 1 [Homo sapiens] 27071 2953 3 67 0.022439909 0.333704341 3.89443171 Up 6.61E-12 2.66E-11 DAPP1 2 GO:0016020//membrane;GO:0043234//protein complex;GO:0044424//intracellular part GO:0004721//phosphoprotein phosphatase activity;GO:0019207//kinase regulator activity;GO:0035091//phosphatidylinositol binding GO:0006464//cellular protein modification process;GO:0016310//phosphorylation;GO:0019222//regulation of metabolic process;GO:0023052//signaling gi|158631203|ref|NP_055210.2|/4.5803e-163/dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [Homo sapiens] 260341 2223 1 22 0.00993628 0.145557209 3.872736639 Up 0.000162788 0.000377968 TFAMP1 1 GO:0005759//mitochondrial matrix - "GO:0006260//DNA replication;GO:0006352//DNA-dependent transcription, initiation;GO:0006355//regulation of transcription, DNA-dependent;GO:0007005//mitochondrion organization" "gi|198282001|ref|NP_001123683.1|/7.44273e-62/transcription factor A, mitochondrial precursor [Sus scrofa]" 3433 3505 9 198 0.056717591 0.83085965 3.872736639 Up 7.36E-33 6.39E-32 IFIT2 4 - GO:0005488//binding GO:0019221//cytokine-mediated signaling pathway;GO:0035455//response to interferon-alpha;GO:0043393//regulation of protein binding;GO:0051707//response to other organism gi|34192824|gb|AAH32839.2|/0/Interferon-induced protein with tetratricopeptide repeats 2 [Homo sapiens] 79132 2631 16 350 0.134326724 1.95658039 3.864516132 Up 5.42E-57 7.90E-56 DHX58 2 GO:0044424//intracellular part GO:0003676//nucleic acid binding;GO:0017111//nucleoside-triphosphatase activity;GO:0032559;GO:0046914//transition metal ion binding GO:0006952//defense response gi|149408122|ref|NP_077024.2|/0/probable ATP-dependent RNA helicase DHX58 [Homo sapiens] 401546 2698 10 218 0.08186935 1.188406582 3.85956125 Up 5.78E-36 5.45E-35 C9orf152 2 - - - gi|163644318|ref|NP_001013011.2|/4.16218e-139/uncharacterized protein C9orf152 [Homo sapiens] 5733 7759 6 129 0.017080823 0.244531301 3.839569775 Up 1.06E-21 6.53E-21 PTGER3 2 GO:0012505//endomembrane system;GO:0016021//integral to membrane GO:0004955//prostaglandin receptor activity "GO:0001660//fever generation;GO:0003014//renal system process;GO:0007187//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0010467//gene expression;GO:0015698//inorganic anion transport;GO:0051480//cytosolic calcium ion homeostasis" "gi|2102645|dbj|BAA19958.1|/0/prostaglandin EP3 receptor subtype isoform [Homo sapiens]//gi|2102647|dbj|BAA19959.1|/0/prostaglandin EP3 receptor subtype isoform [Homo sapiens]//gi|2114196|dbj|BAA19957.1|/0/EP3-IV [Homo sapiens]//gi|38505178|ref|NP_942007.1|/1.80428e-175/prostaglandin E2 receptor EP3 subtype isoform 4 [Homo sapiens]//gi|38505178|ref|NP_942007.1|/2.06636e-174/prostaglandin E2 receptor EP3 subtype isoform 4 [Homo sapiens]//gi|38505182|ref|NP_942009.1|/2.99301e-175/prostaglandin E2 receptor EP3 subtype isoform 6 [Homo sapiens]//gi|38505184|ref|NP_942010.1|/3.71458e-170/prostaglandin E2 receptor EP3 subtype isoform 7 [Homo sapiens]//gi|38505186|ref|NP_942011.1|/0/prostaglandin E2 receptor EP3 subtype isoform 8 [Homo sapiens]//gi|633220|emb|CAA58743.1|/0/prostaglandin E receptor, subtype EP3f [Homo sapiens]" 439927 2884 2 42 0.015317858 0.214192636 3.805622443 Up 9.98E-08 3.09E-07 C1orf180 1 - - - gi|119593635|gb|EAW73229.1|/1.29579e-61/chromosome 1 open reading frame 180 [Homo sapiens] 729475 3589 2 42 0.012308916 0.172118016 3.805622443 Up 9.98E-08 3.09E-07 RAD51AP2 2 - - - gi|149773468|ref|NP_001092688.1|/0/RAD51-associated protein 2 [Homo sapiens] 202500 1686 2 42 0.026202077 0.366388826 3.805622443 Up 9.98E-08 3.09E-07 TCTE1 3 - - - gi|229577123|ref|NP_872345.2|/0/T-complex-associated testis-expressed protein 1 [Homo sapiens] 2819 3083 18 378 0.128962151 1.803303292 3.805622443 Up 9.22E-61 1.44E-59 GPD1 1 GO:0000267//cell fraction;GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex;GO:0044444//cytoplasmic part "GO:0000166//nucleotide binding;GO:0016616//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0016901//oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor;GO:0042802//identical protein binding;GO:0048037//cofactor binding" GO:0006006//glucose metabolic process;GO:0006072//glycerol-3-phosphate metabolic process;GO:0006641//triglyceride metabolic process;GO:0019674//NAD metabolic process;GO:0055114//oxidation-reduction process "gi|380714668|ref|NP_001244128.1|/0/glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 2 [Homo sapiens]//gi|99031626|pdb|1X0X|A/0/Chain A, Co-Structure Of Homo Sapiens Glycerol-3-Phosphate Dehydrogenase 1 Complex With Nad" 162963 2272 1 21 0.009721985 0.135944446 3.805622443 Up 0.00026055 0.00058902 ZNF610 1 GO:0005622//intracellular;GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding;GO:0046872//metal ion binding;GO:0046914//transition metal ion binding "GO:0006351//transcription, DNA-dependent" gi|239787098|ref|NP_001154897.1|/0/zinc finger protein 610 isoform a [Homo sapiens]//gi|239787106|ref|NP_001154899.1|/0/zinc finger protein 610 isoform b [Homo sapiens] 146852 1149 2 41 0.038447956 0.524824775 3.770857025 Up 1.59E-07 4.86E-07 ODF4 4 GO:0019861//flagellum;GO:0031224//intrinsic to membrane;GO:0044447//axoneme part - GO:0048232//male gamete generation;GO:0048869//cellular developmental process gi|171184433|ref|NP_694552.2|/7.2747e-120/outer dense fiber protein 4 [Homo sapiens] 100507674 946 2 40 0.046698416 0.621898279 3.735233115 Up 2.53E-07 7.61E-07 MARK2P9 2 - - - gi|351706291|gb|EHB09210.1|/4.03973e-36/Serine/threonine-protein kinase MARK2 [Heterocephalus glaber] 6445 1661 1 20 0.013298224 0.177096861 3.735233115 Up 0.000416326 0.000919576 SGCG 2 GO:0016011//dystroglycan complex;GO:0031224//intrinsic to membrane;GO:0043232 - GO:0006996//organelle organization;GO:0048513//organ development gi|4557847|ref|NP_000222.1|/1.65592e-153/gamma-sarcoglycan [Homo sapiens] 64005 3313 4 79 0.0266687 0.350716466 3.717085769 Up 1.97E-13 8.60E-13 MYO1G 2 GO:0015629//actin cytoskeleton;GO:0016020//membrane GO:0008092//cytoskeletal protein binding;GO:0017111//nucleoside-triphosphatase activity;GO:0032559 - gi|239582755|ref|NP_149043.2|/0/unconventional myosin-Ig [Homo sapiens] 290 3740 10 196 0.059059761 0.770788044 3.70608677 Up 1.56E-31 1.31E-30 ANPEP 2 GO:0000267//cell fraction;GO:0012505//endomembrane system;GO:0016021//integral to membrane;GO:0031988//membrane-bounded vesicle;GO:0044444//cytoplasmic part GO:0004871//signal transducer activity;GO:0008238//exopeptidase activity;GO:0046914//transition metal ion binding GO:0019538//protein metabolic process;GO:0032501//multicellular organismal process;GO:0044237//cellular metabolic process;GO:0048646//anatomical structure formation involved in morphogenesis;GO:0048869//cellular developmental process;GO:0051704 gi|62089422|dbj|BAD93155.1|/0/membrane alanine aminopeptidase precursor variant [Homo sapiens] 3238 813 2 39 0.054337886 0.705544745 3.698707239 Up 4.03E-07 1.19E-06 HOXD12 3 GO:0005694//chromosome;GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0003677//DNA binding "GO:0006351//transcription, DNA-dependent;GO:0032501//multicellular organismal process" gi|194353946|ref|NP_067016.3|/6.04923e-135/homeobox protein Hox-D12 [Homo sapiens] 5470 3430 7 136 0.045078267 0.583170153 3.69341294 Up 3.34E-22 2.10E-21 PPEF2 2 GO:0031513//nonmotile primary cilium;GO:0044424//intracellular part GO:0004721//phosphoprotein phosphatase activity;GO:0046914//transition metal ion binding GO:0006464//cellular protein modification process;GO:0006796//phosphate-containing compound metabolic process;GO:0050953//sensory perception of light stimulus;GO:0051606//detection of stimulus gi|23312386|ref|NP_006230.2|/0/serine/threonine-protein phosphatase with EF-hands 2 [Homo sapiens] 254778 3471 13 251 0.082727905 1.063578643 3.684408856 Up 7.64E-40 7.94E-39 C8orf46 3 - - - gi|294862516|sp|Q5R5R7.3|CH046_PONAB/1.42362e-102/RecName: Full=Uncharacterized protein C8orf46 homolog 388533 500 2 38 0.088353402 1.117799967 3.661232534 Up 6.41E-07 1.86E-06 KRTDAP 1 - - GO:0048869//cellular developmental process gi|349501070|ref|NP_001231776.1|/1.22695e-31/keratinocyte differentiation-associated protein isoform 2 precursor [Homo sapiens] //gi|46409408|ref|NP_997275.1|/6.96802e-40/keratinocyte differentiation-associated protein isoform 1 precursor [Homo sapiens] 84073 3207 3 56 0.020662629 0.256826343 3.635697442 Up 1.10E-09 3.89E-09 MYCBPAP 4 - - - gi|203098334|ref|NP_115509.4|/0/MYCBP-associated protein [Homo sapiens] 58 1509 31 578 0.45376996 5.633640099 3.634034392 Up 5.69E-89 1.32E-87 ACTA1 3 GO:0000267//cell fraction;GO:0005884//actin filament;GO:0030017//sarcomere;GO:0032432//actin filament bundle GO:0005198//structural molecule activity;GO:0008092//cytoskeletal protein binding;GO:0017111//nucleoside-triphosphatase activity;GO:0032559 GO:0003015//heart process;GO:0006941//striated muscle contraction;GO:0007015//actin filament organization;GO:0009207;GO:0009605//response to external stimulus;GO:0009725//response to hormone stimulus;GO:0009790//embryo development;GO:0010038//response to metal ion;GO:0012501//programmed cell death;GO:0030048//actin filament-based movement;GO:0030239//myofibril assembly;GO:0040007//growth;GO:0043501//skeletal muscle adaptation;GO:0048747//muscle fiber development;GO:0060415//muscle tissue morphogenesis "gi|4501881|ref|NP_001091.1|/0/actin, alpha skeletal muscle [Homo sapiens]" 1524 3264 14 261 0.0947417 1.176090813 3.633856095 Up 6.00E-41 6.38E-40 CX3CR1 1 GO:0016021//integral to membrane GO:0001637//G-protein coupled chemoattractant receptor activity GO:0001525//angiogenesis;GO:0001774//microglial cell activation;GO:0006915//apoptotic process;GO:0006952//defense response;GO:0007166//cell surface receptor signaling pathway;GO:0021987//cerebral cortex development;GO:0030595//leukocyte chemotaxis;GO:0051704 gi|283837934|ref|NP_001164645.1|/0/CX3C chemokine receptor 1 isoform a [Homo sapiens]//gi|283837934|ref|NP_001164645.1|/2.40528e-170/CX3C chemokine receptor 1 isoform a [Homo sapiens]//gi|283837934|ref|NP_001164645.1|/2.54803e-170/CX3C chemokine receptor 1 isoform a [Homo sapiens]//gi|283837934|ref|NP_001164645.1|/5.05813e-171/CX3C chemokine receptor 1 isoform a [Homo sapiens] 3753 3575 4 74 0.024714238 0.304443127 3.622758386 Up 1.98E-12 8.19E-12 KCNE1 1 GO:0000323//lytic vacuole;GO:0005887//integral to plasma membrane GO:0005249//voltage-gated potassium channel activity;GO:0016247//channel regulator activity GO:0002064//epithelial cell development;GO:0003012//muscle system process;GO:0003013;GO:0030001//metal ion transport;GO:0034220//ion transmembrane transport;GO:0042391//regulation of membrane potential;GO:0044057;GO:0050954//sensory perception of mechanical stimulus "gi|119630188|gb|EAX09783.1|/4.90775e-70/potassium voltage-gated channel, Isk-related family, member 1 [Homo sapiens]//gi|119630188|gb|EAX09783.1|/4.91856e-70/potassium voltage-gated channel, Isk-related family, member 1 [Homo sapiens]//gi|119630188|gb|EAX09783.1|/4.97261e-70/potassium voltage-gated channel, Isk-related family, member 1 [Homo sapiens]//gi|119630188|gb|EAX09783.1|/5.06449e-70/potassium voltage-gated channel, Isk-related family, member 1 [Homo sapiens]//gi|119630188|gb|EAX09783.1|/5.14785e-70/potassium voltage-gated channel, Isk-related family, member 1 [Homo sapiens]//gi|119630188|gb|EAX09783.1|/5.23939e-70/potassium voltage-gated channel, Isk-related family, member 1 [Homo sapiens]//gi|119630188|gb|EAX09783.1|/5.37401e-70/potassium voltage-gated channel, Isk-related family, member 1 [Homo sapiens]//gi|119630188|gb|EAX09783.1|/5.64325e-70/potassium voltage-gated channel, Isk-related family, member 1 [Homo sapiens]" 10004 2703 4 73 0.032687163 0.397216531 3.603129579 Up 3.14E-12 1.28E-11 NAALADL1 2 GO:0031224//intrinsic to membrane;GO:0044459//plasma membrane part GO:0008238//exopeptidase activity;GO:0043169//cation binding GO:0019538//protein metabolic process gi|57232740|ref|NP_005459.2|/0/N-acetylated-alpha-linked acidic dipeptidase-like protein [Homo sapiens] 402135 951 2 36 0.046452893 0.556765715 3.583230022 Up 1.61E-06 4.55E-06 OR5K2 1 GO:0031224//intrinsic to membrane GO:0004930//G-protein coupled receptor activity GO:0007606//sensory perception of chemical stimulus gi|52317126|ref|NP_001004737.1|/0/olfactory receptor 5K2 [Homo sapiens] 51309 2141 2 36 0.020633676 0.247306957 3.583230022 Up 1.61E-06 4.54E-06 ARMCX1 1 GO:0031224//intrinsic to membrane - - gi|7706143|ref|NP_057692.1|/0/armadillo repeat-containing X-linked protein 1 [Homo sapiens] 6236 1476 6 107 0.089790043 1.06622269 3.569809506 Up 2.74E-17 1.43E-16 RRAD 1 GO:0016020//membrane GO:0005515//protein binding;GO:0017111//nucleoside-triphosphatase activity;GO:0032561//guanyl ribonucleotide binding GO:0009207;GO:0016049//cell growth;GO:0035556//intracellular signal transduction gi|4759054|ref|NP_004156.1|/1.78726e-132/GTP-binding protein RAD [Homo sapiens]//gi|4759054|ref|NP_004156.1|/1.80249e-132/GTP-binding protein RAD [Homo sapiens] 57091 3179 17 303 0.118119522 1.401853405 3.569016163 Up 1.15E-46 1.38E-45 CASS4 1 GO:0005924//cell-substrate adherens junction;GO:0043232 GO:0004673//protein histidine kinase activity GO:0009987//cellular process gi|255759930|ref|NP_001157586.1|/0/cas scaffolding protein family member 4 isoform b [Homo sapiens] //gi|255759932|ref|NP_001157587.1|/0/cas scaffolding protein family member 4 isoform c [Homo sapiens]//gi|55769585|ref|NP_065089.2|/0/cas scaffolding protein family member 4 isoform a [Homo sapiens] 968 1872 83 1471 0.979344605 11.55732507 3.56084712 Up 2.40E-220 1.50E-218 CD68 1 GO:0005626//insoluble fraction;GO:0016020//membrane;GO:0031090//organelle membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part - - gi|91199548|ref|NP_001242.2|/7.3945e-113/macrosialin isoform A precursor [Homo sapiens]//gi|91199550|ref|NP_001035148.1|/5.378e-113/macrosialin isoform B precursor [Homo sapiens] 5172 4930 17 301 0.076166726 0.897987056 3.559461856 Up 2.87E-46 3.40E-45 SLC26A4 1 GO:0031224//intrinsic to membrane;GO:0044459//plasma membrane part GO:0015103//inorganic anion transmembrane transporter activity;GO:0015301//anion:anion antiporter activity GO:0008104//protein localization;GO:0009653//anatomical structure morphogenesis;GO:0015698//inorganic anion transport;GO:0050954//sensory perception of mechanical stimulus;GO:0055067 gi|4505697|ref|NP_000432.1|/0/pendrin [Homo sapiens] 70 3693 4 70 0.023924561 0.278784891 3.542588037 Up 1.24E-11 4.92E-11 ACTC1 4 GO:0000267//cell fraction;GO:0005884//actin filament;GO:0030017//sarcomere GO:0008092//cytoskeletal protein binding;GO:0017111//nucleoside-triphosphatase activity;GO:0032559 GO:0003015//heart process;GO:0006941//striated muscle contraction;GO:0007015//actin filament organization;GO:0009207;GO:0009790//embryo development;GO:0010033//response to organic substance;GO:0012501//programmed cell death;GO:0030048//actin filament-based movement;GO:0030239//myofibril assembly;GO:0060415//muscle tissue morphogenesis "gi|4885049|ref|NP_005150.1|/0/actin, alpha cardiac muscle 1 proprotein [Homo sapiens]" 146310 796 2 35 0.055498368 0.646703895 3.542588037 Up 2.56E-06 7.08E-06 RNF151 4 GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex GO:0019787//small conjugating protein ligase activity;GO:0046914//transition metal ion binding GO:0048232//male gamete generation;GO:0048869//cellular developmental process gi|87241872|ref|NP_777563.2|/4.14062e-117/RING finger protein 151 [Homo sapiens] 51311 4216 2 35 0.010478345 0.122100641 3.542588037 Up 2.56E-06 7.08E-06 TLR8 4 GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane GO:0003723//RNA binding;GO:0004872//receptor activity GO:0007243//intracellular protein kinase cascade;GO:0009612//response to mechanical stimulus;GO:0019724//B cell mediated immunity;GO:0031349//positive regulation of defense response;GO:0042108//positive regulation of cytokine biosynthetic process;GO:0051707//response to other organism gi|74054086|gb|AAZ95433.1|/0/TLR8 [Homo sapiens] 221091 2600 15 259 0.127432792 1.465132548 3.523222712 Up 1.11E-39 1.15E-38 LRRN4CL 2 GO:0031224//intrinsic to membrane - - gi|158256104|dbj|BAF84023.1|/2.51425e-117/unnamed protein product [Homo sapiens] 7047 3027 4 69 0.029188438 0.335264191 3.521829477 Up 1.96E-11 7.70E-11 TGM4 3 - "GO:0016747//transferase activity, transferring acyl groups other than amino-acyl groups;GO:0016755;GO:0043169//cation binding" GO:0006464//cellular protein modification process gi|156627577|ref|NP_003232.2|/0/protein-glutamine gamma-glutamyltransferase 4 [Homo sapiens] 165545 2650 27 463 0.22505112 2.569718892 3.513285901 Up 1.13E-69 2.02E-68 DQX1 2 GO:0043231//intracellular membrane-bounded organelle GO:0017111//nucleoside-triphosphatase activity;GO:0032559 - gi|163914394|ref|NP_598376.2|/0/ATP-dependent RNA helicase DQX1 [Homo sapiens] 723809 1911 2 34 0.02311706 0.261678915 3.500767862 Up 4.04E-06 1.10E-05 LHFPL3-AS2 1 - - - gi|119603757|gb|EAW83351.1|/2.13098e-06/hCG2041174 [Homo sapiens] 1308 5610 2 34 0.007874635 0.089138753 3.500767862 Up 4.04E-06 1.10E-05 COL17A1 3 GO:0016021//integral to membrane;GO:0030054//cell junction - GO:0007044//cell-substrate junction assembly;GO:0009888//tissue development;GO:0031589//cell-substrate adhesion "gi|179517|gb|AAA35605.1|/0/autoantigen, partial [Homo sapiens]" 6861 1853 2 34 0.023840637 0.26986962 3.500767862 Up 4.04E-06 1.10E-05 SYT5 2 GO:0008021//synaptic vesicle;GO:0010008//endosome membrane;GO:0031224//intrinsic to membrane;GO:0042995//cell projection;GO:0044297//cell body;GO:0044459//plasma membrane part GO:0043169//cation binding GO:0015980//energy derivation by oxidation of organic compounds;GO:0030073//insulin secretion gi|92859638|ref|NP_003171.2|/0/synaptotagmin-5 [Homo sapiens] 1576 2792 2 34 0.015822601 0.179107595 3.500767862 Up 4.04E-06 1.10E-05 CYP3A4 5 GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0042598;GO:0043231//intracellular membrane-bounded organelle "GO:0005506//iron ion binding;GO:0005515//protein binding;GO:0008289//lipid binding;GO:0008395//steroid hydroxylase activity;GO:0016709//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0016712//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0033695;GO:0070643" GO:0006721//terpenoid metabolic process;GO:0006775;GO:0008202//steroid metabolic process;GO:0009820//alkaloid metabolic process;GO:0017144//drug metabolic process;GO:0042493//response to drug;GO:0055114//oxidation-reduction process gi|13435386|ref|NP_059488.2|/0/cytochrome P450 3A4 isoform 1 [Homo sapiens]//gi|322302351|ref|NP_001189784.1|/0/cytochrome P450 3A4 isoform 2 [Homo sapiens] 9610 2698 10 169 0.08186935 0.921287672 3.492256362 Up 3.64E-26 2.63E-25 RIN1 2 GO:0016020//membrane;GO:0043232 GO:0005488//binding;GO:0008047//enzyme activator activity GO:0016192//vesicle-mediated transport;GO:0023052//signaling gi|68989256|ref|NP_004283.2|/0/ras and Rab interactor 1 [Homo sapiens] 6539 3500 13 219 0.082042445 0.920293958 3.487652362 Up 1.72E-33 1.52E-32 SLC6A12 2 GO:0016021//integral to membrane GO:0005283//sodium:amino acid symporter activity;GO:0005326//neurotransmitter transporter activity GO:0001505//regulation of neurotransmitter levels;GO:0006807//nitrogen compound metabolic process;GO:0006865//amino acid transport;GO:0006884//cell volume homeostasis;GO:0006972//hyperosmotic response;GO:0042221//response to chemical stimulus gi|171184404|ref|NP_003035.3|/0/sodium- and chloride-dependent betaine transporter [Homo sapiens] 353149 1883 3 50 0.035191212 0.390544193 3.472198709 Up 1.72E-08 5.63E-08 TBC1D26 4 GO:0000323//lytic vacuole;GO:0005768//endosome;GO:0016020//membrane GO:0004175//endopeptidase activity;GO:0005099//Ras GTPase activator activity;GO:0005515//protein binding;GO:0019783//small conjugating protein-specific protease activity GO:0032318//regulation of Ras GTPase activity;GO:0070646//protein modification by small protein removal gi|148235002|ref|NP_848666.2|/1.54021e-142/TBC1 domain family member 26 [Homo sapiens] 162998 3224 3 50 0.020553676 0.228100098 3.472198709 Up 1.72E-08 5.63E-08 OR7D2 2 GO:0031224//intrinsic to membrane GO:0004930//G-protein coupled receptor activity GO:0007606//sensory perception of chemical stimulus gi|53828729|ref|NP_787079.1|/1.05224e-176/olfactory receptor 7D2 [Homo sapiens] 440896 3182 13 216 0.090241533 0.998398859 3.467752804 Up 6.70E-33 5.83E-32 LOC440896 1 - - - gi|397521894|ref|XP_003831019.1|/3.47623e-31/PREDICTED: LOW QUALITY PROTEIN: putative uncharacterized protein FLJ45355-like [Pan paniscus] 29986 1418 4 66 0.062308464 0.684570539 3.45769914 Up 7.67E-11 2.91E-10 SLC39A2 3 GO:0016021//integral to membrane;GO:0031410//cytoplasmic vesicle GO:0046915//transition metal ion transmembrane transporter activity GO:0006829//zinc ion transport gi|156415986|ref|NP_055394.2|/1.02556e-125/zinc transporter ZIP2 isoform a [Homo sapiens]//gi|156415986|ref|NP_055394.2|/6.52595e-132/zinc transporter ZIP2 isoform a [Homo sapiens] 1268 5901 2 33 0.007486308 0.082250553 3.45769914 Up 6.39E-06 1.70E-05 CNR1 3 GO:0016021//integral to membrane;GO:0042598 GO:0004930//G-protein coupled receptor activity;GO:0005488//binding "GO:0001508//regulation of action potential;GO:0001660//fever generation;GO:0002237//response to molecule of bacterial origin;GO:0002438//acute inflammatory response to antigenic stimulus;GO:0002695;GO:0006635//fatty acid beta-oxidation;GO:0006811//ion transport;GO:0006915//apoptotic process;GO:0007187//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007600//sensory perception;GO:0007611//learning or memory;GO:0008217//regulation of blood pressure;GO:0010975//regulation of neuron projection development;GO:0014046;GO:0014072;GO:0014073;GO:0030073//insulin secretion;GO:0031667//response to nutrient levels;GO:0032769//negative regulation of monooxygenase activity;GO:0043900//regulation of multi-organism process;GO:0048232//male gamete generation;GO:0050795//regulation of behavior;GO:0050804//regulation of synaptic transmission" gi|237681065|ref|NP_149421.2|/0/cannabinoid receptor 1 isoform b [Homo sapiens]//gi|38683844|ref|NP_057167.2|/0/cannabinoid receptor 1 isoform a [Homo sapiens] 391104 1014 3 49 0.06535015 0.71073651 3.443052364 Up 2.71E-08 8.74E-08 VHLL 2 GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part GO:0005515//protein binding GO:0008283//cell proliferation;GO:0009653//anatomical structure morphogenesis;GO:0010468//regulation of gene expression;GO:0016043//cellular component organization;GO:0030154//cell differentiation;GO:0031323//regulation of cellular metabolic process;GO:0032446//protein modification by small protein conjugation;GO:0034641//cellular nitrogen compound metabolic process;GO:0048523//negative regulation of cellular process;GO:0050896//response to stimulus;GO:0051171//regulation of nitrogen compound metabolic process;GO:0080090//regulation of primary metabolic process gi|51972218|ref|NP_001004319.1|/1.26797e-77/von Hippel-Lindau-like protein [Homo sapiens] 780851 217 6 98 0.610737805 6.642274848 3.443052364 Up 1.64E-15 7.93E-15 SNORD3A 1 - - - gi|296489304|gb|DAA31417.1|/1.23247e-15/polypyrimidine tract binding protein 2-like [Bos taurus] 5742 5093 4 65 0.017348008 0.187711198 3.435672833 Up 1.21E-10 4.51E-10 PTGS1 1 GO:0012505//endomembrane system;GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0042598;GO:0043231//intracellular membrane-bounded organelle "GO:0005506//iron ion binding;GO:0016209//antioxidant activity;GO:0016701//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0016705//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" GO:0001516//prostaglandin biosynthetic process;GO:0006939//smooth muscle contraction;GO:0006950//response to stress;GO:0008283//cell proliferation;GO:0014060;GO:0014061//regulation of norepinephrine secretion;GO:0019229//regulation of vasoconstriction;GO:0032502//developmental process;GO:0051384//response to glucocorticoid stimulus gi|249624|gb|AAB22216.1|/0/prostaglandin G/H synthase [Homo sapiens]//gi|76885914|gb|ABA60098.1|/0/cyclooxygenase 1b2 [Homo sapiens] 645158 1429 4 64 0.061828833 0.65871605 3.41330502 Up 1.90E-10 7.01E-10 CBX3P2 2 GO:0044427//chromosomal part;GO:0045120//pronucleus GO:0005515//protein binding GO:0009987//cellular process gi|395540368|ref|XP_003772127.1|/1.45175e-42/PREDICTED: chromobox protein homolog 3 isoform 1 [Sarcophilus harrisii] 200420 1608 5 79 0.068682682 0.722589335 3.395157674 Up 1.37E-12 5.71E-12 ALMS1P 2 - - - "gi|119620132|gb|EAW99726.1|/8.82855e-120/LOC200420, isoform CRA_b [Homo sapiens]" 90594 2566 3 47 0.02582426 0.269396349 3.382931371 Up 6.71E-08 2.10E-07 ZNF439 2 - - - gi|22748625|ref|NP_689475.1|/0/zinc finger protein 439 [Homo sapiens] 83706 2570 31 481 0.266435358 2.752722631 3.369001794 Up 7.33E-70 1.32E-68 FERMT3 5 GO:0015629//actin cytoskeleton;GO:0044459//plasma membrane part GO:0005102//receptor binding GO:0006461//protein complex assembly;GO:0022407//regulation of cell-cell adhesion;GO:0034109//homotypic cell-cell adhesion gi|28626504|ref|NP_113659.3|/0/fermitin family homolog 3 short form [Homo sapiens]//gi|41281905|ref|NP_848537.1|/0/fermitin family homolog 3 long form [Homo sapiens] 9127 2754 2 31 0.016040923 0.165557271 3.367501331 Up 1.59E-05 4.08E-05 P2RX6 3 GO:0005626//insoluble fraction;GO:0016021//integral to membrane;GO:0030425//dendrite;GO:0044297//cell body;GO:0044430//cytoskeletal part;GO:0044459//plasma membrane part GO:0005231//excitatory extracellular ligand-gated ion channel activity;GO:0005515//protein binding;GO:0016502;GO:0032559 GO:0003012//muscle system process;GO:0006811//ion transport;GO:0035587;GO:0051259//protein oligomerization gi|157419148|ref|NP_005437.2|/0/P2X purinoceptor 6 isoform 1 [Homo sapiens]//gi|227116341|ref|NP_001153026.1|/0/P2X purinoceptor 6 isoform 2 [Homo sapiens] 389320 459 2 31 0.096245536 0.993343624 3.367501331 Up 1.59E-05 4.08E-05 C5orf48 1 - - - gi|119569233|gb|EAW48848.1|/3.6432e-76/FLJ27505 protein [Homo sapiens] 162966 2548 2 31 0.017337795 0.178942199 3.367501331 Up 1.59E-05 4.08E-05 ZNF600 2 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding - "gi|119592502|gb|EAW72096.1|/0/zinc finger protein 600, isoform CRA_b [Homo sapiens]" 8972 6513 8 123 0.0271314 0.277763089 3.355819526 Up 8.71E-19 4.84E-18 MGAM 2 GO:0031224//intrinsic to membrane;GO:0044459//plasma membrane part GO:0004558//alpha-glucosidase activity;GO:0005488//binding GO:0005982//starch metabolic process;GO:0007586//digestion "gi|221316699|ref|NP_004659.2|/0/maltase-glucoamylase, intestinal [Homo sapiens]" 6066 188 8 122 0.939929814 9.544484603 3.344042358 Up 1.36E-18 7.51E-18 RNU2-1 3 - - - gi|24940209|emb|CAA24954.2|/1.26016e-12/unnamed protein product [Xenopus laevis] 254050 2045 2 30 0.021602299 0.215763731 3.320195616 Up 2.49E-05 6.31E-05 LRRC43 4 - - - gi|148664213|ref|NP_001091989.1|/0/leucine-rich repeat-containing protein 43 isoform 1 [Homo sapiens] 266812 1965 6 90 0.067445345 0.673644014 3.320195616 Up 6.04E-14 2.70E-13 NAP1L5 2 GO:0043231//intracellular membrane-bounded organelle GO:0005488//binding GO:0034728//nucleosome organization gi|388454312|ref|NP_001253863.1|/3.26139e-42/nucleosome assembly protein 1-like 5 [Macaca mulatta] 63970 3158 4 60 0.027977645 0.279440677 3.320195616 Up 1.15E-09 4.07E-09 TP53AIP1 1 GO:0043231//intracellular membrane-bounded organelle - GO:0012501//programmed cell death gi|304434534|ref|NP_071395.2|/6.38503e-59/p53-regulated apoptosis-inducing protein 1 isoform a [Homo sapiens]//gi|304434536|ref|NP_001182123.1|/3.4963e-57/p53-regulated apoptosis-inducing protein 1 isoform c [Homo sapiens]//gi|304434539|ref|NP_001182124.1|/1.95062e-36/p53-regulated apoptosis-inducing protein 1 isoform b [Homo sapiens]//gi|354459396|ref|NP_001238893.1|/2.79941e-57/p53-regulated apoptosis-inducing protein 1 isoform d [Homo sapiens] 118856 1919 2 30 0.023020689 0.229930604 3.320195616 Up 2.49E-05 6.31E-05 MMP21 1 GO:0044421//extracellular region part GO:0004175//endopeptidase activity;GO:0046914//transition metal ion binding GO:0019538//protein metabolic process gi|22218341|ref|NP_671724.1|/0/matrix metalloproteinase-21 preproprotein [Homo sapiens] 23563 3250 2 30 0.013592831 0.135765178 3.320195616 Up 2.49E-05 6.30E-05 CHST5 4 GO:0000139//Golgi membrane;GO:0031224//intrinsic to membrane GO:0008146//sulfotransferase activity GO:0006024//glycosaminoglycan biosynthetic process;GO:0006041//glucosamine metabolic process;GO:0006464//cellular protein modification process gi|21362052|ref|NP_078809.2|/0/carbohydrate sulfotransferase 5 [Homo sapiens] 340547 3236 12 179 0.081909829 0.813570173 3.312158297 Up 1.73E-26 1.26E-25 VSIG1 1 GO:0031224//intrinsic to membrane - - gi|281599326|ref|NP_001164024.1|/0/V-set and immunoglobulin domain-containing protein 1 isoform 1 precursor [Homo sapiens] //gi|32699028|ref|NP_872413.1|/0/V-set and immunoglobulin domain-containing protein 1 isoform 2 precursor [Homo sapiens] 90634 3051 18 264 0.130314753 1.272659488 3.287774138 Up 3.39E-38 3.38E-37 N4BP2L1 1 - GO:0032559 - gi|119226224|ref|NP_438169.2|/2.73431e-118/NEDD4-binding protein 2-like 1 isoform 1 [Homo sapiens]//gi|119226224|ref|NP_438169.2|/3.68419e-98/NEDD4-binding protein 2-like 1 isoform 1 [Homo sapiens] 118442 2206 3 44 0.030038555 0.293357819 3.287774138 Up 2.59E-07 7.77E-07 GPR62 3 - - - gi|145309315|ref|NP_543141.3|/2.32371e-84/probable G-protein coupled receptor 62 [Homo sapiens] 80737 2914 27 395 0.204662137 1.993691919 3.284126361 Up 2.14E-56 3.11E-55 VWA7 2 - - - gi|153945852|ref|NP_079534.2|/0/von Willebrand factor A domain-containing protein 7 precursor [Homo sapiens] 401027 2259 10 146 0.09777933 0.950576613 3.281201484 Up 1.14E-21 7.01E-21 C2orf66 2 - - - gi|74738241|sp|Q6UXQ4.1|CB066_HUMAN/1.56722e-43/RecName: Full=Uncharacterized protein C2orf66; Flags: Precursor 654463 6051 4 58 0.014601455 0.140977999 3.271286016 Up 2.82E-09 9.73E-09 FER1L6 2 GO:0031224//intrinsic to membrane - - gi|119120884|ref|NP_001034201.2|/0/fer-1-like protein 6 [Homo sapiens] 7125 698 2 29 0.063290403 0.611072973 3.271286016 Up 3.92E-05 9.73E-05 TNNC2 2 GO:0005865//striated muscle thin filament GO:0008092//cytoskeletal protein binding;GO:0046872//metal ion binding GO:0006941//striated muscle contraction "gi|4507617|ref|NP_003270.1|/2.59993e-74/troponin C, skeletal muscle [Homo sapiens]" 3960 1291 3 43 0.051328468 0.489883389 3.254607274 Up 4.06E-07 1.20E-06 LGALS4 3 GO:0016020//membrane;GO:0044444//cytoplasmic part GO:0030246//carbohydrate binding GO:0009987//cellular process gi|5453712|ref|NP_006140.1|/4.06583e-178/galectin-4 [Homo sapiens] 132946 836 3 43 0.079264416 0.756506525 3.254607274 Up 4.06E-07 1.20E-06 ARL9 1 - GO:0032561//guanyl ribonucleotide binding - gi|74749334|sp|Q6T311.1|ARL9_HUMAN/9.15621e-102/RecName: Full=ADP-ribosylation factor-like protein 9 54106 3922 10 143 0.056319099 0.536264377 3.251248262 Up 4.32E-21 2.61E-20 TLR9 3 GO:0000323//lytic vacuole;GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0044459//plasma membrane part;GO:0045335//phagocytic vesicle GO:0003723//RNA binding;GO:0004872//receptor activity;GO:0005126//cytokine receptor binding GO:0001818//negative regulation of cytokine production;GO:0002224//toll-like receptor signaling pathway;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007249//I-kappaB kinase/NF-kappaB cascade;GO:0009607//response to biotic stimulus;GO:0010669//epithelial structure maintenance;GO:0032481//positive regulation of type I interferon production;GO:0042108//positive regulation of cytokine biosynthetic process;GO:0042345//regulation of NF-kappaB import into nucleus;GO:0043406//positive regulation of MAP kinase activity;GO:0043410//positive regulation of MAPK cascade;GO:0043433//negative regulation of sequence-specific DNA binding transcription factor activity;GO:0051091//positive regulation of sequence-specific DNA binding transcription factor activity gi|8394456|ref|NP_059138.1|/0/toll-like receptor 9 precursor [Homo sapiens] 90586 2073 2 28 0.021310517 0.19865945 3.220659942 Up 6.13E-05 0.000149668 AOC4 1 GO:0031224//intrinsic to membrane "GO:0016641//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor;GO:0042802//identical protein binding;GO:0046914//transition metal ion binding;GO:0048037//cofactor binding" GO:0006807//nitrogen compound metabolic process;GO:0006952//defense response;GO:0009987//cellular process gi|114667103|ref|XP_001159482.1|/0/PREDICTED: membrane primary amine oxidase isoform 1 [Pan troglodytes] 440073 6976 2 28 0.006332669 0.059033979 3.220659942 Up 6.13E-05 0.00014963 IQSEC3 1 GO:0044424//intracellular part GO:0005083//small GTPase regulator activity GO:0032011//ARF protein signal transduction gi|282721018|ref|NP_001164209.1|/0/IQ motif and SEC7 domain-containing protein 3 isoform 1 [Homo sapiens]//gi|71143127|ref|NP_056047.1|/0/IQ motif and SEC7 domain-containing protein 3 isoform 2 [Homo sapiens] 84771 2158 3 42 0.030706697 0.286251882 3.220659942 Up 6.34E-07 1.85E-06 DDX11L2 2 GO:0000785//chromatin;GO:0005819//spindle;GO:0031981//nuclear lumen "GO:0000166//nucleotide binding;GO:0003676//nucleic acid binding;GO:0003678//DNA helicase activity;GO:0032559;GO:0042623//ATPase activity, coupled" GO:0000819//sister chromatid segregation;GO:0008283//cell proliferation;GO:0034641//cellular nitrogen compound metabolic process;GO:0051320//S phase;GO:0051704 "gi|119571249|gb|EAW50864.1|/9.23206e-56/hCG2043397, isoform CRA_a [Homo sapiens]//gi|220675805|emb|CAQ52932.1|/2.2294e-73/DEAD/H box polypeptide 11 like 2 [Homo sapiens]" 7732 3252 7 98 0.04754565 0.443226827 3.220659942 Up 1.01E-14 4.70E-14 RNF112 4 GO:0043231//intracellular membrane-bounded organelle GO:0017111//nucleoside-triphosphatase activity;GO:0032561//guanyl ribonucleotide binding;GO:0046914//transition metal ion binding - gi|264681488|ref|NP_009079.2|/0/RING finger protein 112 [Homo sapiens] 399888 1437 2 28 0.030742311 0.286583883 3.220659942 Up 6.13E-05 0.000149649 FAM180B 1 - - - gi|205716727|sp|Q6P0A1.2|F180B_HUMAN/2.00454e-120/RecName: Full=Protein FAM180B 116729 805 2 28 0.05487789 0.511578932 3.220659942 Up 6.13E-05 0.00014961 PPP1R27 3 - - - gi|56090539|ref|NP_001007534.1|/3.41742e-74/protein phosphatase 1 regulatory subunit 27 [Homo sapiens] 390595 1399 3 42 0.047366013 0.441552224 3.220659942 Up 6.34E-07 1.85E-06 UBAP1L 1 - - - gi|254939613|ref|NP_001157164.1|/3.15176e-163/ubiquitin-associated protein 1-like [Homo sapiens] 23439 4773 4 56 0.018511084 0.172562766 3.220659942 Up 6.89E-09 2.32E-08 ATP1B4 2 GO:0012505//endomembrane system;GO:0016021//integral to membrane;GO:0019866//organelle inner membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0044427//chromosomal part GO:0005488//binding;GO:0008556//potassium-transporting ATPase activity "GO:0006351//transcription, DNA-dependent;GO:0009206;GO:0009207;GO:0035725//sodium ion transmembrane transport" gi|215490093|ref|NP_001135919.1|/0/protein ATP1B4 isoform A [Homo sapiens]//gi|6912256|ref|NP_036201.1|/0/protein ATP1B4 isoform B [Homo sapiens] 245711 1830 17 238 0.205192328 1.91282997 3.220659942 Up 5.76E-34 5.17E-33 SPDYA 1 GO:0043231//intracellular membrane-bounded organelle GO:0019900//kinase binding GO:0008283//cell proliferation;GO:0022402//cell cycle process;GO:0032501//multicellular organismal process;GO:0033554//cellular response to stress gi|56961678|ref|NP_001008779.1|/2.40614e-161/speedy protein A isoform 2 [Homo sapiens]//gi|60498969|ref|NP_877433.2|/3.56831e-178/speedy protein A isoform 1 [Homo sapiens]//gi|60498969|ref|NP_877433.2|/3.73772e-178/speedy protein A isoform 1 [Homo sapiens] 140458 3042 2 28 0.014522256 0.135378383 3.220659942 Up 6.13E-05 0.000149687 ASB5 3 - - GO:0007165//signal transduction gi|18254476|ref|NP_543150.1|/0/ankyrin repeat and SOCS box protein 5 [Homo sapiens] 85495 341 16 222 1.036403548 9.575227378 3.207720887 Up 1.16E-31 9.71E-31 RPPH1 1 - - - gi|297694574|ref|XP_002824585.1|/6.22082e-44/PREDICTED: uncharacterized protein LOC100433574 [Pongo abelii] 929 1661 12 166 0.159578692 1.469903946 3.203381951 Up 5.59E-24 3.75E-23 CD14 1 GO:0031224//intrinsic to membrane;GO:0043235//receptor complex;GO:0044421//extracellular region part GO:0001846//opsonin binding;GO:0008329//pattern recognition receptor activity GO:0001819//positive regulation of cytokine production;GO:0006897//endocytosis;GO:0006952//defense response;GO:0007166//cell surface receptor signaling pathway;GO:0012501//programmed cell death;GO:0032496//response to lipopolysaccharide;GO:0070391 gi|4557417|ref|NP_000582.1|/0/monocyte differentiation antigen CD14 precursor [Homo sapiens] 2912 3389 20 275 0.130353205 1.193470326 3.194664734 Up 9.28E-39 9.40E-38 GRM2 1 GO:0016021//integral to membrane;GO:0043005//neuron projection GO:0001640//adenylate cyclase inhibiting G-protein coupled glutamate receptor activity;GO:0016247//channel regulator activity GO:0001505//regulation of neurotransmitter levels;GO:0007166//cell surface receptor signaling pathway;GO:0007270//neuron-neuron synaptic transmission;GO:0007626//locomotory behavior;GO:0023061;GO:0030534//adult behavior;GO:0031280;GO:0050804//regulation of synaptic transmission "gi|27552861|gb|AAH41447.1|/0/Similar to glutamate receptor, metabotropic 2, partial [Homo sapiens]//gi|62087908|dbj|BAD92401.1|/0/glutamate receptor homolog [Homo sapiens]" 60677 3418 13 178 0.084010696 0.765946514 3.188598733 Up 1.61E-25 1.14E-24 CELF6 1 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding "GO:0000380//alternative mRNA splicing, via spliceosome" gi|289547741|ref|NP_001166155.1|/0/CUGBP Elav-like family member 6 isoform 2 [Homo sapiens] //gi|289547743|ref|NP_001166156.1|/2.88005e-146/CUGBP Elav-like family member 6 isoform 3 [Homo sapiens] //gi|70780381|ref|NP_443072.3|/0/CUGBP Elav-like family member 6 isoform 1 [Homo sapiens] 91807 7998 9 123 0.024855608 0.226190423 3.185894524 Up 5.21E-18 2.80E-17 MYLK3 2 GO:0044444//cytoplasmic part GO:0004674//protein serine/threonine kinase activity;GO:0032559 GO:0002526//acute inflammatory response;GO:0006464//cellular protein modification process;GO:0030239//myofibril assembly;GO:0051495//positive regulation of cytoskeleton organization;GO:0070555//response to interleukin-1 gi|146219832|ref|NP_872299.2|/0/putative myosin light chain kinase 3 [Homo sapiens] 167410 3979 10 136 0.055512316 0.502707621 3.178839767 Up 9.56E-20 5.47E-19 LIX1 4 - - - gi|167466286|ref|NP_694966.3|/8.37351e-147/protein limb expression 1 homolog [Homo sapiens] 1180 3093 11 149 0.078555401 0.708527724 3.173041922 Up 1.76E-21 1.08E-20 CLCN1 2 GO:0005886//plasma membrane;GO:0034702//ion channel complex GO:0005254//chloride channel activity GO:0003012//muscle system process;GO:0015698//inorganic anion transport;GO:0034220//ion transmembrane transport;GO:0043269//regulation of ion transport;GO:0050877//neurological system process gi|119433677|ref|NP_000074.2|/0/chloride channel protein 1 [Homo sapiens] 349136 2056 2 27 0.021486722 0.193148417 3.168192523 Up 9.59E-05 0.00022831 WDR86 2 - - - gi|157266266|ref|NP_938026.2|/0/WD repeat-containing protein 86 [Homo sapiens] 54825 4313 2 27 0.010242685 0.092073533 3.168192523 Up 9.59E-05 0.000228339 CDHR2 4 GO:0031224//intrinsic to membrane;GO:0044459//plasma membrane part GO:0046872//metal ion binding GO:0016049//cell growth;GO:0016337//cell-cell adhesion gi|285002214|ref|NP_001165447.1|/0/cadherin-related family member 2 precursor [Homo sapiens] 6795 1261 4 54 0.07006614 0.629838456 3.168192523 Up 1.67E-08 5.49E-08 AURKC 2 GO:0005815//microtubule organizing center;GO:0043231//intracellular membrane-bounded organelle;GO:0044427//chromosomal part GO:0004672//protein kinase activity;GO:0032559 GO:0006464//cellular protein modification process gi|51471708|gb|AAU04399.1|/2.16352e-161/aurora-C [Homo sapiens]//gi|62865639|ref|NP_001015878.1|/3.11271e-175/aurora kinase C isoform 1 [Homo sapiens]//gi|62865641|ref|NP_001015879.1|/5.85378e-167/aurora kinase C isoform 2 [Homo sapiens] 130749 1209 2 27 0.036539869 0.328464141 3.168192523 Up 9.59E-05 0.000228282 CPO 2 - GO:0008235//metalloexopeptidase activity;GO:0046914//transition metal ion binding GO:0019538//protein metabolic process gi|27436871|ref|NP_775100.1|/0/carboxypeptidase O precursor [Homo sapiens] 2302 2666 4 54 0.033140811 0.297909337 3.168192523 Up 1.67E-08 5.48E-08 FOXJ1 3 GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex GO:0000981//sequence-specific DNA binding RNA polymerase II transcription factor activity;GO:0005515//protein binding;GO:0043565//sequence-specific DNA binding;GO:0043566//structure-specific DNA binding GO:0000122//negative regulation of transcription from RNA polymerase II promoter;GO:0002455//humoral immune response mediated by circulating immunoglobulin;GO:0002467//germinal center formation;GO:0002510;GO:0003002//regionalization;GO:0003143//embryonic heart tube morphogenesis;GO:0007010//cytoskeleton organization;GO:0010927;GO:0030323//respiratory tube development;GO:0032321//positive regulation of Rho GTPase activity;GO:0033077//T cell differentiation in thymus;GO:0035088//establishment or maintenance of apical/basal cell polarity;GO:0042036//negative regulation of cytokine biosynthetic process;GO:0042098//T cell proliferation;GO:0043433//negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043627//response to estrogen stimulus;GO:0048232//male gamete generation;GO:0050864;GO:0070848//response to growth factor stimulus gi|50301236|ref|NP_001445.2|/0/forkhead box protein J1 [Homo sapiens] 54831 1924 2 27 0.022960863 0.206399764 3.168192523 Up 9.59E-05 0.000228253 BEST2 2 GO:0034702//ion channel complex;GO:0042995//cell projection GO:0005253//anion channel activity GO:0007606//sensory perception of chemical stimulus;GO:0015698//inorganic anion transport;GO:0042391//regulation of membrane potential gi|119703742|ref|NP_060152.2|/0/bestrophin-2 [Homo sapiens] 79949 3459 5 67 0.03192881 0.284888383 3.157466116 Up 2.91E-10 1.06E-09 PLEKHS1 1 - - - gi|172045921|sp|Q5SXH7.2|CJ081_HUMAN/0/RecName: Full=PH domain-containing protein C10orf81; AltName: Full=Epididymis luminal protein 185; Short=hEL185//gi|301172762|ref|NP_872407.1|/0/PH domain-containing protein C10orf81 isoform 1 [Homo sapiens]//gi|46391075|ref|NP_079165.3|/0/PH domain-containing protein C10orf81 isoform 3 [Homo sapiens] 10677 3163 65 870 0.453918049 4.045484681 3.155808798 Up 4.43E-118 1.40E-116 AVIL 3 GO:0005856//cytoskeleton;GO:0043005//neuron projection GO:0008092//cytoskeletal protein binding GO:0010975//regulation of neuron projection development;GO:0030835//negative regulation of actin filament depolymerization;GO:0048858//cell projection morphogenesis;GO:0050896//response to stimulus gi|295821173|ref|NP_006567.3|/0/advillin [Homo sapiens] 84688 1184 4 53 0.074622806 0.658377026 3.141225475 Up 2.60E-08 8.41E-08 C9orf24 1 GO:0044444//cytoplasmic part GO:0015631//tubulin binding GO:0006461//protein complex assembly "gi|119578863|gb|EAW58459.1|/5.70291e-59/chromosome 9 open reading frame 24, isoform CRA_d [Homo sapiens]//gi|21362074|ref|NP_115985.2|/5.18098e-161/spermatid-specific manchette-related protein 1 isoform 1 [Homo sapiens]//gi|356582253|ref|NP_001239124.1|/1.64705e-93/spermatid-specific manchette-related protein 1 isoform 4 [Homo sapiens]//gi|356582253|ref|NP_001239124.1|/4.0116e-87/spermatid-specific manchette-related protein 1 isoform 4 [Homo sapiens]" 157777 5114 17 224 0.073426273 0.644225327 3.133197101 Up 2.74E-31 2.28E-30 MCMDC2 1 - GO:0003676//nucleic acid binding;GO:0032559 GO:0006259//DNA metabolic process gi|209954821|ref|NP_775789.3|/0/MCM domain-containing protein 2 isoform a [Homo sapiens]//gi|209954823|ref|NP_001129632.1|/0/MCM domain-containing protein 2 isoform b [Homo sapiens] 2529 2428 2 26 0.018194687 0.157498044 3.113744739 Up 0.00014969 0.000348489 FUT7 3 GO:0000139//Golgi membrane;GO:0031224//intrinsic to membrane GO:0008417//fucosyltransferase activity "GO:0002252;GO:0006464//cellular protein modification process;GO:0019317;GO:0043367//CD4-positive, alpha-beta T cell differentiation" "gi|4758406|ref|NP_004470.1|/0/alpha-(1,3)-fucosyltransferase [Homo sapiens]" 6898 2757 3 39 0.024035202 0.208055088 3.113744739 Up 2.40E-06 6.67E-06 TAT 2 GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part GO:0016846//carbon-sulfur lyase activity;GO:0031406//carboxylic acid binding;GO:0048037//cofactor binding;GO:0070547 GO:0006006//glucose metabolic process;GO:0006558//L-phenylalanine metabolic process;GO:0006570//tyrosine metabolic process;GO:0006950//response to stress;GO:0008652//cellular amino acid biosynthetic process;GO:0009063//cellular amino acid catabolic process;GO:0009064//glutamine family amino acid metabolic process;GO:0010038//response to metal ion;GO:0031960//response to corticosteroid stimulus;GO:0043648//dicarboxylic acid metabolic process gi|4507369|ref|NP_000344.1|/0/tyrosine aminotransferase [Homo sapiens] 2125 6587 2 26 0.00670665 0.05805454 3.113744739 Up 0.00014969 0.000348532 EVPL 2 GO:0005856//cytoskeleton;GO:0005911//cell-cell junction GO:0005515//protein binding GO:0006464//cellular protein modification process;GO:0030216//keratinocyte differentiation gi|156104874|ref|NP_001979.2|/0/envoplakin [Homo sapiens] 611 1114 2 26 0.039655926 0.343272219 3.113744739 Up 0.00014969 0.000348574 OPN1SW 2 GO:0016021//integral to membrane;GO:0031513//nonmotile primary cilium GO:0004888//transmembrane signaling receptor activity GO:0006464//cellular protein modification process;GO:0007166//cell surface receptor signaling pathway;GO:0050953//sensory perception of light stimulus gi|4502387|ref|NP_001699.1|/0/short-wave-sensitive opsin 1 [Homo sapiens] 1296 4447 4 52 0.019868091 0.171983473 3.113744739 Up 4.05E-08 1.29E-07 COL8A2 2 GO:0005576//extracellular region - - gi|397482860|ref|XP_003812634.1|/8.61391e-116/PREDICTED: collagen alpha-2(VIII) chain [Pan paniscus] 81607 3520 7 90 0.043925697 0.376054116 3.097803195 Up 3.44E-13 1.48E-12 PVRL4 2 GO:0031224//intrinsic to membrane;GO:0070161 - GO:0007155//cell adhesion;GO:0045216//cell-cell junction organization gi|222136611|ref|NP_112178.2|/0/poliovirus receptor-related protein 4 precursor [Homo sapiens] 80739 2560 6 77 0.051769572 0.442385883 3.09512906 Up 1.92E-11 7.57E-11 C6orf25 2 GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle GO:0004871//signal transducer activity;GO:0005539//glycosaminoglycan binding - gi|168984771|emb|CAQ07019.1|/4.88106e-106/chromosome 6 open reading frame 25 [Homo sapiens]//gi|168984773|emb|CAQ07021.1|/2.40098e-106/chromosome 6 open reading frame 25 [Homo sapiens]//gi|19913377|ref|NP_612117.1|/1.39756e-119/protein G6b isoform G6b-C precursor [Homo sapiens]//gi|19913377|ref|NP_612117.1|/5.08129e-115/protein G6b isoform G6b-C precursor [Homo sapiens]//gi|19913381|ref|NP_612119.1|/8.52004e-106/protein G6b isoform G6b-E precursor [Homo sapiens]//gi|219518025|gb|AAI43851.1|/5.66584e-97/C6orf25 protein [Homo sapiens] 1733 1876 3 38 0.035322522 0.2979211 3.076270033 Up 3.73E-06 1.02E-05 DIO1 1 GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0042598;GO:0043231//intracellular membrane-bounded organelle GO:0005488//binding;GO:0016491//oxidoreductase activity GO:0009058//biosynthetic process;GO:0042403//thyroid hormone metabolic process gi|4557522|ref|NP_000783.2|/6.0335e-131/type I iodothyronine deiodinase isoform a [Homo sapiens]//gi|47132603|ref|NP_998758.1|/3.23495e-88/type I iodothyronine deiodinase isoform b [Homo sapiens]//gi|89357935|ref|NP_001034804.1|/3.69476e-103/type I iodothyronine deiodinase isoform c [Homo sapiens]//gi|89357938|ref|NP_001034805.1|/5.69641e-77/type I iodothyronine deiodinase isoform d [Homo sapiens] 286190 3727 2 25 0.011853153 0.098657729 3.05716121 Up 0.00023308 0.000530444 LOC286190 1 GO:0043231//intracellular membrane-bounded organelle GO:0003824//catalytic activity;GO:0043169//cation binding - gi|67970573|dbj|BAE01629.1|/7.02538e-24/unnamed protein product [Macaca fascicularis] 49 1384 4 50 0.063839164 0.531354563 3.05716121 Up 9.74E-08 3.02E-07 ACR 2 GO:0001669//acrosomal vesicle;GO:0032991//macromolecular complex "GO:0003676//nucleic acid binding;GO:0004175//endopeptidase activity;GO:0016811//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;GO:0046914//transition metal ion binding;GO:0048029//monosaccharide binding" GO:0009725//response to hormone stimulus;GO:0035036//sperm-egg recognition;GO:0045762//positive regulation of adenylate cyclase activity;GO:0051603//proteolysis involved in cellular protein catabolic process gi|148613878|ref|NP_001088.2|/0/acrosin precursor [Homo sapiens] 4993 1036 2 25 0.042641604 0.354920229 3.05716121 Up 0.00023308 0.000530507 OR2C1 2 GO:0031224//intrinsic to membrane;GO:0044444//cytoplasmic part GO:0004930//G-protein coupled receptor activity GO:0007166//cell surface receptor signaling pathway;GO:0007606//sensory perception of chemical stimulus gi|118442843|ref|NP_036500.2|/1.61708e-176/olfactory receptor 2C1 [Homo sapiens] 128854 1215 8 100 0.1454377 1.21052628 3.05716121 Up 2.30E-14 1.05E-13 TSPY26P 1 - - - gi|119596794|gb|EAW76388.1|/0/hCG1641475 [Homo sapiens] 4323 3558 88 1099 0.546311089 4.542994897 3.055849073 Up 2.43E-144 9.49E-143 MMP14 2 GO:0016021//integral to membrane;GO:0044421//extracellular region part;GO:0048770 GO:0001071//nucleic acid binding transcription factor activity;GO:0004175//endopeptidase activity;GO:0005102//receptor binding;GO:0008047//enzyme activator activity;GO:0046914//transition metal ion binding GO:0001763//morphogenesis of a branching structure;GO:0001953//negative regulation of cell-matrix adhesion;GO:0006950//response to stress;GO:0008347//glial cell migration;GO:0009605//response to external stimulus;GO:0022602//ovulation cycle process;GO:0030323//respiratory tube development;GO:0048545//response to steroid hormone stimulus;GO:0048646//anatomical structure formation involved in morphogenesis;GO:0050673//epithelial cell proliferation;GO:0051345//positive regulation of hydrolase activity gi|804994|emb|CAA58519.1|/0/MT-MMP [Homo sapiens] 206338 4630 6 74 0.028624212 0.235072177 3.037795885 Up 7.13E-11 2.71E-10 AQPEP 4 GO:0031224//intrinsic to membrane "GO:0046914//transition metal ion binding;GO:0070011//peptidase activity, acting on L-amino acid peptides" GO:0019538//protein metabolic process gi|194239713|ref|NP_776161.3|/0/aminopeptidase Q [Homo sapiens] 9363 1128 9 111 0.17623684 1.447319387 3.037795885 Up 1.00E-15 4.89E-15 RAB33A 2 GO:0016020//membrane GO:0017111//nucleoside-triphosphatase activity;GO:0032561//guanyl ribonucleotide binding GO:0006810//transport;GO:0009207;GO:0035556//intracellular signal transduction gi|4758996|ref|NP_004785.1|/6.61409e-134/ras-related protein Rab-33A [Homo sapiens] 51151 2769 10 123 0.079770136 0.653330083 3.033891431 Up 2.83E-17 1.48E-16 SLC45A2 2 GO:0030659//cytoplasmic vesicle membrane;GO:0031224//intrinsic to membrane - GO:0006582//melanin metabolic process;GO:0006810//transport;GO:0032502//developmental process;GO:0050953//sensory perception of light stimulus gi|61635915|ref|NP_057264.3|/0/membrane-associated transporter protein isoform a [Homo sapiens]//gi|61636000|ref|NP_001012527.1|/0/membrane-associated transporter protein isoform b [Homo sapiens] 462 1599 4 49 0.055255411 0.450710957 3.028014864 Up 1.51E-07 4.61E-07 SERPINC1 3 GO:0016020//membrane;GO:0043234//protein complex;GO:0044421//extracellular region part GO:0004866//endopeptidase inhibitor activity;GO:0005539//glycosaminoglycan binding;GO:0016728;GO:0019899//enzyme binding GO:0006259//DNA metabolic process;GO:0006508//proteolysis;GO:0007599//hemostasis;GO:0010466//negative regulation of peptidase activity;GO:0031348//negative regulation of defense response;GO:0031667//response to nutrient levels gi|4502261|ref|NP_000479.1|/0/antithrombin-III precursor [Homo sapiens] 3059 2050 20 245 0.215496104 1.757772734 3.028014864 Up 4.59E-33 4.01E-32 HCLS1 4 GO:0016020//membrane;GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0003676//nucleic acid binding;GO:0005515//protein binding "GO:0006351//transcription, DNA-dependent;GO:0007260//tyrosine phosphorylation of STAT protein;GO:0008283//cell proliferation;GO:0009719;GO:0030099//myeloid cell differentiation" gi|317373440|sp|P14317.3|HCLS1_HUMAN/0/RecName: Full=Hematopoietic lineage cell-specific protein; AltName: Full=Hematopoietic cell-specific LYN substrate 1; AltName: Full=LckBP1; AltName: Full=p75 63940 1472 7 85 0.105039711 0.849300962 3.015341034 Up 3.04E-12 1.24E-11 GPSM3 1 - GO:0005488//binding - gi|5578775|emb|CAB51287.1|/1.50488e-54/G18.1a protein [Homo sapiens] 151306 2023 8 97 0.08734889 0.705222812 3.013217863 Up 8.49E-14 3.78E-13 GPBAR1 1 GO:0016020//membrane GO:0004871//signal transducer activity - gi|24850109|ref|NP_733800.1|/2.21479e-124/G-protein coupled bile acid receptor 1 [Homo sapiens]//gi|24850109|ref|NP_733800.1|/2.45264e-124/G-protein coupled bile acid receptor 1 [Homo sapiens]//gi|24850109|ref|NP_733800.1|/3.51696e-124/G-protein coupled bile acid receptor 1 [Homo sapiens] 100132677 2603 11 133 0.093343011 0.751498249 3.009155837 Up 1.91E-18 1.04E-17 BSN-AS2 1 - - - gi|21755868|dbj|BAC04774.1|/8.25091e-52/unnamed protein product [Homo sapiens] 683 1497 13 157 0.191816004 1.542511293 3.007486051 Up 1.56E-21 9.56E-21 BST1 2 GO:0031224//intrinsic to membrane "GO:0016799//hydrolase activity, hydrolyzing N-glycosyl compounds" GO:0006955//immune response;GO:0032501//multicellular organismal process gi|168229159|ref|NP_004325.2|/1.95101e-166/ADP-ribosyl cyclase 2 precursor [Homo sapiens] 283726 3146 65 783 0.456370881 3.660610694 3.003805705 Up 1.19E-101 3.25E-100 FAM154B 1 - - - gi|60223083|ref|NP_001008227.1|/0/protein FAM154B [Homo sapiens] 56203 4099 2 24 0.010777434 0.086115995 2.998267521 Up 0.000362076 0.000804881 LMOD3 3 GO:0043232 GO:0008092//cytoskeletal protein binding - gi|54607116|ref|NP_938012.2|/0/leiomodin-3 [Homo sapiens] 146227 2931 2 24 0.015072228 0.120433116 2.998267521 Up 0.000362076 0.000804599 BEAN1 2 GO:0016020//membrane - - gi|295842186|ref|NP_001171491.1|/1.02723e-106/protein BEAN1 isoform 1 [Homo sapiens]//gi|295842186|ref|NP_001171491.1|/9.56767e-102/protein BEAN1 isoform 1 [Homo sapiens]//gi|308387388|ref|NP_001184154.1|/1.58334e-98/protein BEAN1 isoform 3 [Homo sapiens]//gi|308387388|ref|NP_001184154.1|/3.58036e-74/protein BEAN1 isoform 3 [Homo sapiens] 206426 4243 2 24 0.010411667 0.083193369 2.998267521 Up 0.000362076 0.000804412 PIP5K1P1 1 GO:0005849//mRNA cleavage factor complex;GO:0016020//membrane;GO:0016604//nuclear body;GO:0031252//cell leading edge;GO:0044431//Golgi apparatus part GO:0016307//phosphatidylinositol phosphate kinase activity;GO:0019899//enzyme binding;GO:0032559 GO:0006644//phospholipid metabolic process;GO:0006796//phosphate-containing compound metabolic process;GO:0023052//signaling;GO:0048870//cell motility gi|189053510|dbj|BAG35676.1|/0/unnamed protein product [Homo sapiens] 2147 2018 3 36 0.032836993 0.262380671 2.998267521 Up 8.97E-06 2.36E-05 F2 3 GO:0000267//cell fraction;GO:0016020//membrane;GO:0044421//extracellular region part;GO:0044431//Golgi apparatus part;GO:0044432//endoplasmic reticulum part GO:0004175//endopeptidase activity;GO:0004872//receptor activity;GO:0005102//receptor binding;GO:0046872//metal ion binding GO:0001932//regulation of protein phosphorylation;GO:0002376//immune system process;GO:0002526//acute inflammatory response;GO:0006606//protein import into nucleus;GO:0006915//apoptotic process;GO:0008283//cell proliferation;GO:0009967//positive regulation of signal transduction;GO:0010524//positive regulation of calcium ion transport into cytosol;GO:0010543//regulation of platelet activation;GO:0010557//positive regulation of macromolecule biosynthetic process;GO:0016049//cell growth;GO:0018108//peptidyl-tyrosine phosphorylation;GO:0018200;GO:0030162//regulation of proteolysis;GO:0030194//positive regulation of blood coagulation;GO:0030195//negative regulation of blood coagulation;GO:0045686//negative regulation of glial cell differentiation;GO:0072376;GO:0072593//reactive oxygen species metabolic process gi|4503635|ref|NP_000497.1|/0/prothrombin preproprotein [Homo sapiens] 11136 1798 2 24 0.024569912 0.196323395 2.998267521 Up 0.000362076 0.000804787 SLC7A9 1 GO:0016021//integral to membrane GO:0000099;GO:0003823//antigen binding GO:0000101//sulfur amino acid transport;GO:0002376//immune system process;GO:0006807//nitrogen compound metabolic process;GO:0007599//hemostasis;GO:0019752//carboxylic acid metabolic process;GO:0065003 "gi|7657591|ref|NP_055085.1|/0/B(0,+)-type amino acid transporter 1 [Homo sapiens]" 22854 3434 2 24 0.012864502 0.102792505 2.998267521 Up 0.000362076 0.000804693 NTNG1 2 GO:0031225//anchored to membrane GO:0005488//binding GO:0048667//cell morphogenesis involved in neuron differentiation gi|164414431|ref|NP_001106697.1|/0/netrin-G1 isoform 1 precursor [Homo sapiens]//gi|164414437|ref|NP_001106699.1|/0/netrin-G1 isoform 2 precursor [Homo sapiens]//gi|54312078|ref|NP_055732.2|/0/netrin-G1 isoform 3 precursor [Homo sapiens] 286186 2520 2 24 0.017530437 0.140075184 2.998267521 Up 0.000362076 0.000804505 LOC286186 1 - - - gi|119577496|gb|EAW57092.1|/3.85628e-30/hCG1995581 [Homo sapiens] 5341 2866 9 107 0.069363278 0.549108406 2.984847005 Up 5.66E-15 2.66E-14 PLEK 2 GO:0001726//ruffle;GO:0005626//insoluble fraction;GO:0044444//cytoplasmic part GO:0019901//protein kinase binding;GO:0035091//phosphatidylinositol binding;GO:0042802//identical protein binding GO:0006650//glycerophospholipid metabolic process;GO:0006887//exocytosis;GO:0007200//phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007243//intracellular protein kinase cascade;GO:0008361//regulation of cell size;GO:0009306//protein secretion;GO:0009968//negative regulation of signal transduction;GO:0010543//regulation of platelet activation;GO:0010677;GO:0010922//positive regulation of phosphatase activity;GO:0030030//cell projection organization;GO:0030042//actin filament depolymerization;GO:0030097//hemopoiesis;GO:0031334//positive regulation of protein complex assembly;GO:0034109//homotypic cell-cell adhesion;GO:0051017//actin filament bundle assembly gi|156616273|ref|NP_002655.2|/0/pleckstrin [Homo sapiens] 6689 3537 23 271 0.143633606 1.12689832 2.971892106 Up 8.40E-36 7.90E-35 SPIB 1 GO:0005856//cytoskeleton;GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0003677//DNA binding "GO:0002573//myeloid leukocyte differentiation;GO:0006355//regulation of transcription, DNA-dependent" gi|345842493|ref|NP_001230927.1|/3.7076e-76/transcription factor Spi-B isoform 2 [Homo sapiens]//gi|345842499|ref|NP_001230929.1|/1.4263e-126/transcription factor Spi-B isoform 4 [Homo sapiens]//gi|61888836|ref|NP_003112.2|/2.9076e-127/transcription factor Spi-B isoform 1 [Homo sapiens]//gi|61888836|ref|NP_003112.2|/9.86286e-121/transcription factor Spi-B isoform 1 [Homo sapiens] 29999 1911 4 46 0.04623412 0.354036179 2.936866976 Up 5.55E-07 1.62E-06 FSCN3 2 GO:0005856//cytoskeleton GO:0003779//actin binding GO:0007281//germ cell development gi|9966791|ref|NP_065102.1|/0/fascin-3 [Homo sapiens] 11063 3280 8 92 0.053874026 0.412538499 2.936866976 Up 7.35E-13 3.11E-12 SOX30 2 GO:0043231//intracellular membrane-bounded organelle GO:0003677//DNA binding;GO:0003700//sequence-specific DNA binding transcription factor activity "GO:0006355//regulation of transcription, DNA-dependent;GO:0048545//response to steroid hormone stimulus" gi|30581117|ref|NP_848511.1|/0/transcription factor SOX-30 isoform a [Homo sapiens]//gi|5902112|ref|NP_008948.1|/0/transcription factor SOX-30 isoform b [Homo sapiens] 10517 3494 17 194 0.10747051 0.81663752 2.925755021 Up 1.21E-25 8.58E-25 FBXW10 1 - - - gi|389885061|ref|NP_001254514.1|/0/F-box/WD repeat-containing protein 10 isoform 1 [Homo sapiens]//gi|389885064|ref|NP_001254515.1|/0/F-box/WD repeat-containing protein 10 isoform 2 [Homo sapiens] 64577 2567 52 593 0.447446136 3.397655366 2.924753597 Up 2.03E-75 3.95E-74 ALDH8A1 2 GO:0044424//intracellular part "GO:0016620//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" GO:0001523//retinoid metabolic process;GO:0035238//vitamin A biosynthetic process gi|12007648|ref|NP_072090.1|/0/aldehyde dehydrogenase family 8 member A1 isoform 1 [Homo sapiens]//gi|25952152|ref|NP_739577.1|/0/aldehyde dehydrogenase family 8 member A1 isoform 2 [Homo sapiens]//gi|301500698|ref|NP_001180409.1|/0/aldehyde dehydrogenase family 8 member A1 isoform 3 [Homo sapiens] 57758 4550 24 273 0.116509981 0.882473658 2.921099661 Up 1.78E-35 1.66E-34 SCUBE2 1 - GO:0046872//metal ion binding - "gi|283046663|ref|NP_066025.2|/0/signal peptide, CUB and EGF-like domain-containing protein 2 isoform 1 precursor [Homo sapiens]//gi|283046665|ref|NP_001164161.1|/0/signal peptide, CUB and EGF-like domain-containing protein 2 isoform 2 precursor [Homo sapiens]" 29931 2903 34 384 0.258699249 1.945515471 2.91080468 Up 3.78E-49 4.75E-48 LINC00312 2 - - - gi|5566604|gb|AAD45398.1|/3.32233e-49/NAG-7 protein [Homo sapiens] 3663 2900 7 79 0.053316708 0.400663328 2.909730847 Up 4.05E-11 1.57E-10 IRF5 1 GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0003676//nucleic acid binding "GO:0006351//transcription, DNA-dependent;GO:0019221//cytokine-mediated signaling pathway" gi|14249182|ref|NP_116032.1|/0/interferon regulatory factor 5 isoform b [Homo sapiens]//gi|148833494|ref|NP_001092099.1|/0/interferon regulatory factor 5 isoform d [Homo sapiens]//gi|334883190|ref|NP_001229381.1|/0/interferon regulatory factor 5 isoform e [Homo sapiens] 440730 8522 11 124 0.028511131 0.214008319 2.908069712 Up 9.18E-17 4.68E-16 TRIM67 3 GO:0043232 GO:0046914//transition metal ion binding - gi|134288906|ref|NP_001004342.3|/0/tripartite motif-containing protein 67 [Homo sapiens] 339894 2016 4 45 0.043826092 0.328301212 2.905158117 Up 8.55E-07 2.46E-06 LOC339894 1 - - - gi|119599123|gb|EAW78717.1|/2.27445e-22/hCG2045402 [Homo sapiens] 5672 2059 6 67 0.064366248 0.478595881 2.89443171 Up 1.47E-09 5.15E-09 PSG4 1 - - GO:0006950//response to stress;GO:0022414//reproductive process;GO:0048870//cell motility gi|42560235|ref|NP_002771.2|/0/pregnancy-specific beta-1-glycoprotein 4 isoform 1 precursor [Homo sapiens]//gi|47419900|ref|NP_998798.1|/1.33371e-180/pregnancy-specific beta-1-glycoprotein 4 isoform 2 precursor [Homo sapiens] 100130705 3803 48 535 0.278790647 2.069083212 2.891737601 Up 1.90E-67 3.30E-66 LOC100130705 1 - - - "gi|119604101|gb|EAW83695.1|/5.76782e-105/hCG2014363, isoform CRA_b [Homo sapiens]" 10716 3186 3 33 0.020798824 0.152341655 2.872736639 Up 3.29E-05 8.24E-05 TBR1 2 GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0003676//nucleic acid binding GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0006935//chemotaxis;GO:0007420//brain development gi|189069124|dbj|BAG35462.1|/0/unnamed protein product [Homo sapiens] 653641 5379 28 306 0.11497933 0.836701182 2.863337941 Up 7.64E-39 7.75E-38 GOLGA6C 1 - - - gi|256542288|ref|NP_001157876.1|/0/putative golgin subfamily A member 6C [Homo sapiens] 80726 4421 12 131 0.059954808 0.435814104 2.861765521 Up 2.20E-17 1.16E-16 KIAA1683 1 GO:0043231//intracellular membrane-bounded organelle - - gi|224451032|ref|NP_001138776.1|/0/uncharacterized protein KIAA1683 isoform a [Homo sapiens]//gi|54606862|ref|NP_079525.1|/0/uncharacterized protein KIAA1683 isoform b [Homo sapiens] 4640 3658 24 262 0.144920835 1.053435842 2.861765521 Up 1.91E-33 1.69E-32 MYO1A 3 GO:0005884//actin filament;GO:0016323//basolateral plasma membrane;GO:0030427//site of polarized growth;GO:0042995//cell projection;GO:0044297//cell body GO:0008092//cytoskeletal protein binding;GO:0017111//nucleoside-triphosphatase activity;GO:0032559 GO:0008104//protein localization;GO:0030031//cell projection assembly;GO:0050954//sensory perception of mechanical stimulus;GO:0051640//organelle localization gi|4885503|ref|NP_005370.1|/0/unconventional myosin-Ia [Homo sapiens] 201181 2596 16 174 0.136137754 0.985814179 2.856248516 Up 1.26E-22 8.02E-22 ZNF385C 1 - - - gi|337299688|ref|NP_001229633.1|/1.31904e-150/zinc finger protein 385C [Homo sapiens] 10737 1357 25 267 0.406933504 2.8938893 2.830144762 Up 1.08E-33 9.63E-33 RFPL3-AS1 1 - GO:0046914//transition metal ion binding - gi|211829910|gb|AAH69753.2|/2.74066e-108/Ret finger protein-like 3 [Homo sapiens]//gi|211829910|gb|AAH69753.2|/3.61251e-108/Ret finger protein-like 3 [Homo sapiens] 6123 1547 3 32 0.042834552 0.304235693 2.82834252 Up 5.06E-05 0.00012439 RPL3L 2 GO:0030529//ribonucleoprotein complex;GO:0044444//cytoplasmic part GO:0003676//nucleic acid binding;GO:0005198//structural molecule activity GO:0006412//translation;GO:0019080;GO:0031016//pancreas development gi|189053728|dbj|BAG35980.1|/0/unnamed protein product [Homo sapiens] 23460 5296 4 42 0.016683044 0.116641156 2.805622443 Up 3.09E-06 8.50E-06 ABCA6 2 GO:0031224//intrinsic to membrane GO:0017111//nucleoside-triphosphatase activity;GO:0032559 GO:0051234//establishment of localization gi|27436953|ref|NP_525023.2|/0/ATP-binding cassette sub-family A member 6 [Homo sapiens] 7851 3071 4 42 0.028770239 0.201149971 2.805622443 Up 3.09E-06 8.50E-06 MALL 4 GO:0012505//endomembrane system;GO:0030135//coated vesicle;GO:0031224//intrinsic to membrane GO:0005488//binding GO:0055092//sterol homeostasis gi|13162283|ref|NP_005425.1|/1.17016e-76/MAL-like protein [Homo sapiens] 440585 530 4 42 0.166704533 1.165531247 2.805622443 Up 3.09E-06 8.50E-06 FAM183A 2 - - - gi|157837999|ref|NP_001094846.2|/2.92948e-77/protein FAM183A [Homo sapiens] 7499 2944 4 42 0.030011346 0.209827296 2.805622443 Up 3.09E-06 8.50E-06 XG 1 GO:0044464//cell part - - gi|213688346|ref|NP_001135391.1|/7.7352e-70/glycoprotein Xg isoform 2 precursor [Homo sapiens]//gi|213688348|ref|NP_001135392.1|/7.64149e-54/glycoprotein Xg isoform 3 precursor [Homo sapiens]//gi|28212220|ref|NP_780778.1|/5.48402e-60/glycoprotein Xg isoform 1 precursor [Homo sapiens] 100128288 2129 64 665 0.663999267 4.594058109 2.790515551 Up 1.52E-80 3.18E-79 LOC100128288 1 - - - gi|119610464|gb|EAW90058.1|/1.59634e-74/hCG1985372 [Homo sapiens] 3662 5463 8 83 0.032346111 0.223458764 2.788344452 Up 3.39E-11 1.32E-10 IRF4 1 GO:0000786//nucleosome;GO:0031981//nuclear lumen GO:0001071//nucleic acid binding transcription factor activity;GO:0003676//nucleic acid binding;GO:0005515//protein binding GO:0001773//myeloid dendritic cell activation;GO:0002697;GO:0016573//histone acetylation;GO:0019221//cytokine-mediated signaling pathway;GO:0042108//positive regulation of cytokine biosynthetic process;GO:0046649//lymphocyte activation;GO:0051099//positive regulation of binding gi|157816963|ref|NP_001099578.1|/0/interferon regulatory factor 4 [Rattus norvegicus] //gi|167555104|ref|NP_002451.2|/0/interferon regulatory factor 4 isoform 1 [Homo sapiens]//gi|305632828|ref|NP_001182215.1|/0/interferon regulatory factor 4 isoform 2 [Homo sapiens] 254956 724 3 31 0.091526315 0.629757905 2.78253883 Up 7.76E-05 0.000187047 MORN5 2 - - - gi|223278407|ref|NP_940871.2|/2.56856e-96/MORN repeat-containing protein 5 [Homo sapiens] 51129 1967 3 31 0.033688384 0.231797012 2.78253883 Up 7.76E-05 0.000187023 ANGPTL4 1 GO:0031012//extracellular matrix GO:0005515//protein binding;GO:0030234//enzyme regulator activity GO:0006629//lipid metabolic process;GO:0006915//apoptotic process;GO:0006950//response to stress;GO:0023052//signaling;GO:0045765//regulation of angiogenesis;GO:0048869//cellular developmental process;GO:0051004;GO:0051259//protein oligomerization;GO:0055088//lipid homeostasis gi|37181670|gb|AAQ88642.1|/0/NL2 [Homo sapiens] 3902 1995 24 247 0.265724519 1.82097739 2.776709751 Up 1.06E-30 8.74E-30 LAG3 5 GO:0009986//cell surface;GO:0031224//intrinsic to membrane GO:0004872//receptor activity;GO:0042287//MHC protein binding GO:0001912//positive regulation of leukocyte mediated cytotoxicity;GO:0007165//signal transduction;GO:0042036//negative regulation of cytokine biosynthetic process;GO:0050863//regulation of T cell activation gi|167614500|ref|NP_002277.4|/0/lymphocyte activation gene 3 protein precursor [Homo sapiens] 23418 5266 4 40 0.016778086 0.111719668 2.735233115 Up 7.21E-06 1.92E-05 CRB1 1 GO:0031224//intrinsic to membrane;GO:0044459//plasma membrane part GO:0005488//binding;GO:0046872//metal ion binding GO:0001754//eye photoreceptor cell differentiation;GO:0007154//cell communication;GO:0009987//cellular process;GO:0050953//sensory perception of light stimulus gi|221044266|dbj|BAH13810.1|/0/unnamed protein product [Homo sapiens]//gi|302370926|ref|NP_001180569.1|/0/crumbs homolog 1 isoform 2 precursor [Homo sapiens]//gi|384081579|ref|NP_001244894.1|/0/crumbs homolog 1 isoform 3 [Homo sapiens]//gi|384081581|ref|NP_001244895.1|/0/crumbs homolog 1 isoform 4 precursor [Homo sapiens] //gi|41327708|ref|NP_957705.1|/0/crumbs homolog 1 isoform 1 precursor [Homo sapiens]//gi|6014482|gb|AAF01361.1|AF154671_1/0/CRB1 [Homo sapiens] 64091 1667 6 60 0.079502162 0.529378319 2.735233115 Up 2.86E-08 9.22E-08 POPDC2 2 GO:0031224//intrinsic to membrane - - gi|22209004|ref|NP_071418.2|/0/popeye domain-containing protein 2 [Homo sapiens] 645811 2191 4 40 0.040325606 0.268514729 2.735233115 Up 7.21E-06 1.91E-05 CCDC154 1 - - - gi|221136814|ref|NP_001137452.1|/0/coiled-coil domain-containing protein 154 [Homo sapiens] 3683 5226 3 30 0.01267988 0.084431081 2.735233115 Up 0.000118765 0.000279983 ITGAL 1 GO:0005887//integral to plasma membrane;GO:0009986//cell surface GO:0004871//signal transducer activity;GO:0005515//protein binding GO:0002286//T cell activation involved in immune response;GO:0002682//regulation of immune system process;GO:0006952//defense response;GO:0007166//cell surface receptor signaling pathway;GO:0007599//hemostasis;GO:0009967//positive regulation of signal transduction;GO:0016337//cell-cell adhesion;GO:0042098//T cell proliferation gi|167466215|ref|NP_002200.2|/0/integrin alpha-L isoform a precursor [Homo sapiens]//gi|167466217|ref|NP_001107852.1|/0/integrin alpha-L isoform b precursor [Homo sapiens] 6665 1394 71 708 1.125016423 7.470006577 2.731163451 Up 8.60E-84 1.88E-82 SOX15 1 GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0003676//nucleic acid binding GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0008406//gonad development;GO:0016202//regulation of striated muscle tissue development;GO:0042246//tissue regeneration;GO:0048468//cell development;GO:0051276//chromosome organization gi|5902106|ref|NP_008873.1|/1.1272e-120/protein SOX-15 [Homo sapiens] 154197 1920 11 108 0.126547842 0.827319055 2.708760904 Up 7.86E-14 3.50E-13 PNLDC1 1 GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle GO:0005488//binding - "gi|119567997|gb|EAW47612.1|/0/poly(A)-specific ribonuclease (PARN)-like domain containing 1, isoform CRA_a [Homo sapiens]" 93953 3178 87 854 0.604684237 3.952341642 2.708453784 Up 7.26E-100 1.95E-98 ACRC 4 GO:0043231//intracellular membrane-bounded organelle - - gi|119625689|gb|EAX05284.1|/0/acidic repeat containing [Homo sapiens] 2913 4260 3 29 0.015555176 0.100124163 2.686323515 Up 0.000181237 0.000418812 GRM3 2 GO:0016021//integral to membrane;GO:0030425//dendrite;GO:0044430//cytoskeletal part;GO:0044456//synapse part GO:0001640//adenylate cyclase inhibiting G-protein coupled glutamate receptor activity;GO:0016247//channel regulator activity GO:0007193//adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007270//neuron-neuron synaptic transmission;GO:0051931;GO:0051969 gi|46358417|ref|NP_000831.2|/0/metabotropic glutamate receptor 3 precursor [Homo sapiens] 84734 969 4 38 0.091179982 0.576780169 2.661232534 Up 1.67E-05 4.27E-05 FAM167B 2 - - - gi|110238585|ref|NP_116037.2|/2.11235e-42/protein FAM167B [Homo sapiens] 283888 2632 4 38 0.033568922 0.212348018 2.661232534 Up 1.67E-05 4.27E-05 IL21R-AS1 1 GO:0031224//intrinsic to membrane GO:0004896//cytokine receptor activity GO:0046649//lymphocyte activation gi|189053516|dbj|BAG35682.1|/1.70413e-129/unnamed protein product [Homo sapiens] 339483 2341 13 123 0.12266064 0.772777018 2.655379808 Up 2.76E-15 1.32E-14 MTMR9LP 1 - - - "gi|119627955|gb|EAX07550.1|/4.85178e-80/hCG41615, isoform CRA_b [Homo sapiens]" 2633 3050 5 47 0.036210411 0.22664624 2.645965777 Up 1.58E-06 4.45E-06 GBP1 2 GO:0031224//intrinsic to membrane GO:0017111//nucleoside-triphosphatase activity;GO:0032561//guanyl ribonucleotide binding GO:0009207;GO:0019221//cytokine-mediated signaling pathway gi|166706903|ref|NP_002044.2|/0/interferon-induced guanylate-binding protein 1 [Homo sapiens] 162515 1803 3 28 0.036752663 0.228408786 2.635697442 Up 0.000275846 0.000622344 SLC16A11 1 - - - gi|23503293|ref|NP_699188.1|/1.87317e-97/monocarboxylate transporter 11 [Homo sapiens] 629 2646 7 65 0.05843479 0.361305038 2.628317911 Up 1.48E-08 4.85E-08 CFB 5 GO:0016020//membrane GO:0004175//endopeptidase activity;GO:0005515//protein binding GO:0006952//defense response;GO:0006956//complement activation gi|67782358|ref|NP_001701.2|/0/complement factor B preproprotein [Homo sapiens] 4547 4093 12 111 0.064759396 0.398870332 2.622758386 Up 9.43E-14 4.18E-13 MTTP 2 GO:0044432//endoplasmic reticulum part GO:0005488//binding;GO:0022892 GO:0010876//lipid localization;GO:0044238//primary metabolic process;GO:0044260;GO:0051234//establishment of localization gi|153285408|ref|NP_000244.2|/0/microsomal triglyceride transfer protein large subunit precursor [Homo sapiens] 79852 1810 6 55 0.073221052 0.446924965 2.609702233 Up 2.29E-07 6.92E-07 EPHX3 1 - GO:0003824//catalytic activity - gi|13376164|ref|NP_079070.1|/1.00508e-167/epoxide hydrolase 3 precursor [Homo sapiens]//gi|13376164|ref|NP_079070.1|/9.82696e-168/epoxide hydrolase 3 precursor [Homo sapiens] 345193 3583 32 290 0.197272459 1.190424044 2.59321411 Up 2.10E-33 1.85E-32 LRIT3 3 - - - "gi|385298685|ref|NP_940908.3|/0/leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 precursor [Homo sapiens]" 85001 2501 59 533 0.521076644 3.134469278 2.588653694 Up 4.99E-60 7.66E-59 MGC16275 1 - - - gi|119569304|gb|EAW48919.1|/5.52557e-21/hCG2028158 [Homo sapiens] 25764 1351 5 47 0.085283207 0.511673599 2.5848902 Up 1.58E-06 4.45E-06 C15orf63 1 - - - "gi|119597649|gb|EAW77243.1|/2.00367e-58/hCG2003792, isoform CRA_c [Homo sapiens] //gi|119597649|gb|EAW77243.1|/8.94917e-55/hCG2003792, isoform CRA_c [Homo sapiens] " 133060 1869 3 27 0.035454816 0.212473594 2.583230022 Up 0.000418676 0.000923802 OTOP1 1 GO:0031224//intrinsic to membrane;GO:0044421//extracellular region part - GO:0009581//detection of external stimulus;GO:0009888//tissue development;GO:0042471//ear morphogenesis gi|120660054|gb|AAI30431.1|/0/Otopetrin 1 [Homo sapiens] 1325 1238 7 63 0.124893743 0.748463119 2.583230022 Up 3.36E-08 1.08E-07 CORT 4 GO:0000267//cell fraction;GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex;GO:0044427//chromosomal part;GO:0044444//cytoplasmic part GO:0003676//nucleic acid binding;GO:0005179//hormone activity "GO:0006259//DNA metabolic process;GO:0006351//transcription, DNA-dependent;GO:0007067//mitosis;GO:0007188//adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007267//cell-cell signaling;GO:0033554//cellular response to stress" gi|56205681|emb|CAI19195.1|/1.07173e-71/cortistatin [Homo sapiens] 6518 2454 3 27 0.027002874 0.161822798 2.583230022 Up 0.000418676 0.000923909 SLC2A5 1 GO:0031224//intrinsic to membrane GO:0015149//hexose transmembrane transporter activity GO:0008645//hexose transport;GO:0044238//primary metabolic process "gi|207447703|ref|NP_001129057.1|/5.87286e-129/solute carrier family 2, facilitated glucose transporter member 5 isoform 2 [Homo sapiens]//gi|350538429|ref|NP_001233520.1|/0/solute carrier family 2, facilitated glucose transporter member 5 [Pan troglodytes]" 80741 738 13 117 0.389090187 2.331739341 2.583230022 Up 3.23E-14 1.47E-13 LY6G5C 3 - - - gi|262118212|ref|NP_079538.3|/5.12733e-79/lymphocyte antigen 6 complex locus protein G5c precursor [Homo sapiens] 2886 2285 7 63 0.06766672 0.40551306 2.583230022 Up 3.36E-08 1.08E-07 GRB7 1 GO:0044444//cytoplasmic part "GO:0030674//protein binding, bridging" GO:0002376//immune system process;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007599//hemostasis gi|334883159|ref|NP_001229371.1|/0/growth factor receptor-bound protein 7 isoform b [Homo sapiens] 286187 1111 3 27 0.059644511 0.357437575 2.583230022 Up 0.000418676 0.000924016 PPP1R42 2 - - - gi|61966709|ref|NP_001013648.1|/1.76898e-107/protein phosphatase 1 regulatory subunit 42 [Homo sapiens] 140876 4292 4 36 0.020585602 0.123365376 2.583230022 Up 3.84E-05 9.54E-05 FAM65C 2 - - - gi|221042658|dbj|BAH13006.1|/0/unnamed protein product [Homo sapiens] 5961 3027 3 27 0.021891329 0.131190336 2.583230022 Up 0.000418676 0.000924123 PRPH2 4 GO:0031224//intrinsic to membrane - GO:0009987//cellular process;GO:0048856//anatomical structure development;GO:0050953//sensory perception of light stimulus gi|118572596|ref|NP_000313.2|/0/peripherin-2 [Homo sapiens] 285429 4772 56 502 0.259209479 1.547226098 2.577493652 Up 2.28E-56 3.30E-55 DCAF4L1 3 GO:0031461//cullin-RING ubiquitin ligase complex - GO:0032446//protein modification by small protein conjugation gi|146149345|ref|NP_001025126.2|/0/DDB1- and CUL4-associated factor 4-like protein 1 [Homo sapiens] 126432 3062 14 125 0.100991806 0.600420244 2.571734383 Up 4.89E-15 2.31E-14 RINL 1 - - - gi|307938276|ref|NP_001182762.1|/0/ras and Rab interactor-like protein isoform 1 [Homo sapiens] 395 5118 2 25 0.012163189 0.071843954 2.562345265 Up 0.00023308 0.00053057 ARHGAP6 2 GO:0015629//actin cytoskeleton;GO:0044444//cytoplasmic part "GO:0005099//Ras GTPase activator activity;GO:0019899//enzyme binding;GO:0019904//protein domain specific binding;GO:0030674//protein binding, bridging;GO:0060229//lipase activator activity" GO:0001953//negative regulation of cell-matrix adhesion;GO:0007044//cell-substrate junction assembly;GO:0007265//Ras protein signal transduction;GO:0008154//actin polymerization or depolymerization;GO:0009966//regulation of signal transduction;GO:0010863//positive regulation of phospholipase C activity;GO:0032232//negative regulation of actin filament bundle assembly;GO:0032319//regulation of Rho GTPase activity;GO:0033124//regulation of GTP catabolic process gi|95091875|ref|NP_038286.2|/0/rho GTPase-activating protein 6 isoform 1 [Homo sapiens]//gi|95091988|ref|NP_006116.2|/0/rho GTPase-activating protein 6 isoform 3 [Homo sapiens] 55811 5421 19 168 0.077417204 0.455806354 2.55769493 Up 1.18E-19 6.73E-19 ADCY10 1 GO:0000267//cell fraction;GO:0016020//membrane;GO:0030427//site of polarized growth;GO:0043005//neuron projection;GO:0043232;GO:0044297//cell body;GO:0044444//cytoplasmic part GO:0009975//cyclase activity;GO:0019899//enzyme binding;GO:0032559;GO:0046914//transition metal ion binding GO:0006164//purine nucleotide biosynthetic process;GO:0006915//apoptotic process;GO:0007165//signal transduction;GO:0048232//male gamete generation "gi|119611211|gb|EAW90805.1|/0/testicular soluble adenylyl cyclase, isoform CRA_b [Homo sapiens]//gi|209976994|ref|NP_060887.2|/0/adenylate cyclase type 10 isoform 1 [Homo sapiens]" 147686 3712 6 53 0.035703153 0.209999568 2.556262974 Up 5.22E-07 1.53E-06 ZNF418 1 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding "GO:0006351//transcription, DNA-dependent" gi|18916783|dbj|BAB85542.1|/0/KIAA1956 protein [Homo sapiens] 340286 1647 10 88 0.134112633 0.785849848 2.550808544 Up 7.29E-11 2.77E-10 FAM183B 1 - - - gi|119614518|gb|EAW94112.1|/0/hCG1645872 [Homo sapiens] 10740 5125 4 35 0.017239688 0.100444156 2.542588037 Up 5.79E-05 0.000141688 RFPL1-AS1 2 - GO:0046914//transition metal ion binding - "gi|119580206|gb|EAW59802.1|/1.83131e-109/ret finger protein-like 1, isoform CRA_b [Homo sapiens]" 845 2716 4 35 0.032530708 0.18953472 2.542588037 Up 5.79E-05 0.00014167 CASQ2 3 GO:0005788//endoplasmic reticulum lumen GO:0046872//metal ion binding GO:0006936//muscle contraction;GO:0048513//organ development gi|119395727|ref|NP_001223.2|/0/calsequestrin-2 precursor [Homo sapiens] 5507 2576 4 35 0.034298681 0.19983552 2.542588037 Up 5.79E-05 0.000141706 PPP1R3C 5 GO:0042598;GO:0044444//cytoplasmic part GO:0004721//phosphoprotein phosphatase activity;GO:0005515//protein binding GO:0005978//glycogen biosynthetic process;GO:0005980//glycogen catabolic process gi|4885559|ref|NP_005389.1|/0/protein phosphatase 1 regulatory subunit 3C [Homo sapiens] 164633 3001 10 87 0.073603301 0.426386806 2.534320421 Up 1.09E-10 4.10E-10 CABP7 2 GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part GO:0046872//metal ion binding - gi|21322238|ref|NP_620398.1|/1.42169e-119/calcium-binding protein 7 [Mus musculus] 3266 1266 6 52 0.104684126 0.604115722 2.528782238 Up 7.85E-07 2.26E-06 ERAS 2 GO:0016020//membrane GO:0017111//nucleoside-triphosphatase activity;GO:0032561//guanyl ribonucleotide binding GO:0035556//intracellular signal transduction gi|31559833|ref|NP_853510.1|/6.4117e-112/GTPase ERas precursor [Homo sapiens] 2252 3936 11 95 0.061730655 0.354992368 2.52372901 Up 1.63E-11 6.45E-11 FGF7 3 GO:0043231//intracellular membrane-bounded organelle;GO:0044421//extracellular region part GO:0005104//fibroblast growth factor receptor binding;GO:0005539//glycosaminoglycan binding GO:0001934//positive regulation of protein phosphorylation;GO:0001942//hair follicle development;GO:0006935//chemotaxis;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0009611//response to wounding;GO:0022602//ovulation cycle process;GO:0030036//actin cytoskeleton organization;GO:0030323//respiratory tube development;GO:0030335//positive regulation of cell migration;GO:0032940//secretion by cell;GO:0034613//cellular protein localization;GO:0046470//phosphatidylcholine metabolic process;GO:0048875//chemical homeostasis within a tissue;GO:0050679//positive regulation of epithelial cell proliferation;GO:0060638//mesenchymal-epithelial cell signaling;GO:0061138//morphogenesis of a branching epithelium gi|4503705|ref|NP_002000.1|/1.47291e-111/fibroblast growth factor 7 precursor [Homo sapiens] 100750247 2051 7 60 0.075386862 0.43026507 2.512840694 Up 1.14E-07 3.51E-07 HIF1A-AS2 1 - - - - 440044 2377 7 60 0.06504773 0.37125522 2.512840694 Up 1.14E-07 3.51E-07 SLC22A20 4 GO:0031224//intrinsic to membrane GO:0008509//anion transmembrane transporter activity GO:0006820//anion transport gi|172048842|sp|A6NK97.1|S22AK_HUMAN/0/RecName: Full=Solute carrier family 22 member 20; AltName: Full=Organic anion transporter 6//gi|291167771|ref|NP_001004326.4|/1.67044e-143/solute carrier family 22 member 20 [Homo sapiens] 7148 13143 32 274 0.053779747 0.30662429 2.511337103 Up 1.35E-30 1.10E-29 TNXB 3 GO:0005581//collagen;GO:0044464//cell part GO:0005102//receptor binding;GO:0005539//glycosaminoglycan binding GO:0007010//cytoskeleton organization;GO:0023052//signaling;GO:0044238//primary metabolic process;GO:0044259//multicellular organismal macromolecule metabolic process;GO:0085029//extracellular matrix assembly gi|188528648|ref|NP_061978.6|/0/tenascin-X isoform 1 precursor [Homo sapiens] 27285 1536 9 77 0.129423929 0.737309806 2.51016656 Up 1.65E-09 5.79E-09 TEKT2 2 GO:0005924//cell-substrate adherens junction;GO:0005930//axoneme;GO:0015630//microtubule cytoskeleton;GO:0031981//nuclear lumen - GO:0007010//cytoskeleton organization;GO:0048870//cell motility gi|16507950|ref|NP_055281.2|/0/tektin-2 [Homo sapiens] 695 2611 20 171 0.169194566 0.9632516 2.50922944 Up 1.35E-19 7.70E-19 BTK 2 GO:0031982//vesicle;GO:0043231//intracellular membrane-bounded organelle;GO:0044425//membrane part;GO:0044444//cytoplasmic part GO:0004713//protein tyrosine kinase activity;GO:0005515//protein binding;GO:0032559;GO:0035091//phosphatidylinositol binding;GO:0043169//cation binding GO:0002441;GO:0006468//protein phosphorylation;GO:0006917//induction of apoptosis;GO:0006979//response to oxidative stress;GO:0007243//intracellular protein kinase cascade;GO:0009888//tissue development;GO:0019932//second-messenger-mediated signaling;GO:0021700//developmental maturation "gi|119623263|gb|EAX02858.1|/0/Bruton agammaglobulinemia tyrosine kinase, isoform CRA_c [Homo sapiens]" 440603 4986 11 94 0.048730818 0.27728481 2.508462253 Up 2.45E-11 9.58E-11 BCL2L15 2 GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part - GO:0012501//programmed cell death gi|58219054|ref|NP_001010922.1|/1.08511e-82/bcl-2-like protein 15 [Homo sapiens] 64787 3156 45 383 0.314947965 1.784893384 2.502652506 Up 4.98E-42 5.42E-41 EPS8L2 3 GO:0031252//cell leading edge;GO:0044424//intracellular part GO:0003779//actin binding GO:0007265//Ras protein signal transduction "gi|119622781|gb|EAX02376.1|/0/EPS8-like 2, isoform CRA_b [Homo sapiens]" 375323 4895 4 34 0.018049725 0.102159021 2.500767862 Up 8.73E-05 0.000209001 LHFPL4 2 GO:0031224//intrinsic to membrane - - gi|38348398|ref|NP_940962.1|/1.72896e-133/lipoma HMGIC fusion partner-like 4 protein [Homo sapiens] 342 939 4 34 0.09409308 0.532554213 2.500767862 Up 8.73E-05 0.000209027 APOC1P1 1 GO:0034385;GO:0043231//intracellular membrane-bounded organelle GO:0005543//phospholipid binding;GO:0008047//enzyme activator activity;GO:0055102//lipase inhibitor activity GO:0009895;GO:0010872//regulation of cholesterol esterification;GO:0010899//regulation of phosphatidylcholine catabolic process;GO:0010915;GO:0015914//phospholipid transport;GO:0030301//cholesterol transport;GO:0031327;GO:0034369//plasma lipoprotein particle remodeling;GO:0034377;GO:0045806//negative regulation of endocytosis;GO:0051004;GO:0071830 "gi|259563386|sp|P86336.1|APO1A_PANPA/7.90825e-23/RecName: Full=Truncated apolipoprotein C-I, acidic form; Short=Apo-CIA'; Short=ApoC-IA'; AltName: Full=Apolipoprotein C1A//gi|290463117|sp|P0CE37.1|APO1A_PANTR/3.44724e-29/RecName: Full=Apolipoprotein C-I, acidic form; Short=Apo-CIA; Short=ApoC-IA; AltName: Full=Apolipoprotein C1A; Contains: RecName: Full=Truncated apolipoprotein C-I, acidic form; Short=Apo-CIA'; Short=ApoC-IA'; Flags: Precursor//gi|290463117|sp|P0CE37.1|APO1A_PANTR/5.03124e-29/RecName: Full=Apolipoprotein C-I, acidic form; Short=Apo-CIA; Short=ApoC-IA; AltName: Full=Apolipoprotein C1A; Contains: RecName: Full=Truncated apolipoprotein C-I, acidic form; Short=Apo-CIA'; Short=ApoC-IA'; Flags: Precursor" 10699 4942 19 161 0.084920814 0.479152364 2.496294385 Up 1.98E-18 1.08E-17 CORIN 2 GO:0031224//intrinsic to membrane GO:0004175//endopeptidase activity;GO:0004888//transmembrane signaling receptor activity;GO:0008236//serine-type peptidase activity GO:0001990 gi|29244926|ref|NP_006578.2|/0/atrial natriuretic peptide-converting enzyme [Homo sapiens] 29765 1322 20 169 0.334165667 1.880207366 2.492256362 Up 3.01E-19 1.69E-18 TMOD4 2 GO:0043232 GO:0008092//cytoskeletal protein binding GO:0003012//muscle system process gi|156415984|ref|NP_037485.2|/1.64528e-166/tropomodulin-4 [Homo sapiens] 646999 2602 38 321 0.3225816 1.814463517 2.491806994 Up 2.66E-35 2.47E-34 LOC646999 1 - - - gi|194374197|dbj|BAG56994.1|/3.69857e-52/unnamed protein product [Homo sapiens] 375316 4293 23 194 0.118339638 0.664647448 2.489655907 Up 7.15E-22 4.44E-21 RBM44 2 - GO:0005488//binding - gi|207028821|ref|NP_001073973.2|/0/RNA-binding protein 44 [Homo sapiens] 54857 2443 7 59 0.063290403 0.355204979 2.488593148 Up 1.71E-07 5.21E-07 GDPD2 1 GO:0016020//membrane;GO:0031224//intrinsic to membrane;GO:0043232;GO:0044424//intracellular part GO:0008081//phosphoric diester hydrolase activity;GO:0043169//cation binding GO:0019400;GO:0044238//primary metabolic process gi|21361649|ref|NP_060181.2|/0/glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform 2 [Homo sapiens]//gi|284055242|ref|NP_001164663.1|/0/glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform 1 [Homo sapiens] 100128378 3019 8 67 0.058531568 0.326409049 2.479394211 Up 2.51E-08 8.12E-08 C3orf74 1 - - - gi|74711261|sp|Q6ZRV3.1|CC074_HUMAN/7.96569e-70/RecName: Full=Putative uncharacterized protein C3orf74 150209 2439 4 33 0.036225257 0.1989998 2.45769914 Up 0.000131141 0.000307371 AIFM3 1 GO:0019866//organelle inner membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part GO:0003824//catalytic activity;GO:0016505//apoptotic protease activator activity;GO:0043169//cation binding;GO:0050662//coenzyme binding;GO:0051536//iron-sulfur cluster binding GO:0006091//generation of precursor metabolites and energy;GO:0006919//activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0012502//induction of programmed cell death;GO:0051234//establishment of localization;GO:0051881//regulation of mitochondrial membrane potential gi|21389617|ref|NP_653305.1|/0/apoptosis-inducing factor 3 isoform 1 [Homo sapiens]//gi|221045472|dbj|BAH14413.1|/0/unnamed protein product [Homo sapiens]//gi|226437568|ref|NP_001139760.1|/0/apoptosis-inducing factor 3 isoform 3 [Homo sapiens]//gi|65787454|ref|NP_001018070.1|/0/apoptosis-inducing factor 3 isoform 2 [Homo sapiens] 219670 3399 8 66 0.05198788 0.285590181 2.45769914 Up 3.75E-08 1.20E-07 ENKUR 1 GO:0042995//cell projection GO:0019904//protein domain specific binding - gi|21450721|ref|NP_659447.1|/1.92058e-135/enkurin isoform 1 [Homo sapiens]//gi|21450721|ref|NP_659447.1|/3.62026e-135/enkurin isoform 1 [Homo sapiens]//gi|393281726|ref|NP_001257312.1|/1.10513e-96/enkurin isoform 2 [Homo sapiens]//gi|393281726|ref|NP_001257312.1|/1.58878e-19/enkurin isoform 2 [Homo sapiens] 100129583 1627 4 33 0.054304488 0.298316234 2.45769914 Up 0.000131141 0.000307334 FAM47E 2 - - - gi|211971092|ref|NP_001130042.1|/0/protein FAM47E isoform a [Homo sapiens]//gi|339515660|ref|NP_001229865.1|/1.71843e-163/protein FAM47E isoform b [Homo sapiens] 728130 5543 239 1971 0.952393252 5.229886285 2.457150273 Up 2.88E-205 1.69E-203 FAM22D 1 - - - gi|150170710|ref|NP_001092808.1|/0/protein FAM22A [Homo sapiens] 284723 3172 26 214 0.181052054 0.992272819 2.454332289 Up 1.26E-23 8.28E-23 SLC25A34 1 GO:0019866//organelle inner membrane;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle - GO:0051234//establishment of localization gi|46409330|ref|NP_997231.1|/3.35418e-143/solute carrier family 25 member 34 [Homo sapiens] 80122 4165 1 20 0.012909615 0.070626143 2.45175638 Up 0.000416326 0.000919682 YSK4 3 - GO:0004672//protein kinase activity;GO:0032559 GO:0006464//cellular protein modification process gi|63998898|ref|NP_001018056.1|/0/SPS1/STE20-related protein kinase YSK4 isoform 2 [Homo sapiens]//gi|68077164|ref|NP_079328.3|/0/SPS1/STE20-related protein kinase YSK4 isoform 1 [Homo sapiens] 4838 2086 11 90 0.1164774 0.634568786 2.445726498 Up 1.22E-10 4.55E-10 NODAL 4 GO:0044421//extracellular region part GO:0005102//receptor binding GO:0000904//cell morphogenesis involved in differentiation;GO:0001667//ameboidal cell migration;GO:0001825//blastocyst formation;GO:0003143//embryonic heart tube morphogenesis;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0007179//transforming growth factor beta receptor signaling pathway;GO:0007267//cell-cell signaling;GO:0007417//central nervous system development;GO:0007501//mesodermal cell fate specification;GO:0008283//cell proliferation;GO:0009855//determination of bilateral symmetry;GO:0009946//proximal/distal axis specification;GO:0014020;GO:0022603//regulation of anatomical structure morphogenesis;GO:0033504//floor plate development;GO:0045595//regulation of cell differentiation;GO:0048609//multicellular organismal reproductive process;GO:0048704//embryonic skeletal system morphogenesis;GO:0060425//lung morphogenesis gi|222352098|ref|NP_060525.3|/0/nodal homolog precursor [Homo sapiens] 132014 2790 16 130 0.126671545 0.685314072 2.435672833 Up 9.30E-15 4.33E-14 IL17RE 2 GO:0031224//intrinsic to membrane;GO:0044424//intracellular part GO:0004871//signal transducer activity - gi|301129232|ref|NP_705616.2|/0/interleukin-17 receptor E isoform 5 [Homo sapiens] 5794 3935 16 130 0.089812861 0.48590248 2.435672833 Up 9.30E-15 4.33E-14 PTPRH 1 GO:0016021//integral to membrane;GO:0044424//intracellular part GO:0004725//protein tyrosine phosphatase activity;GO:0005488//binding GO:0006464//cellular protein modification process;GO:0012501//programmed cell death gi|241896924|ref|NP_002833.3|/0/receptor-type tyrosine-protein phosphatase H isoform 1 precursor [Homo sapiens]//gi|241896926|ref|NP_001154912.1|/0/receptor-type tyrosine-protein phosphatase H isoform 2 precursor [Homo sapiens] 149428 2412 44 354 0.402938403 2.158621304 2.421478952 Up 1.36E-37 1.34E-36 BNIPL 1 GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part GO:0005515//protein binding GO:0008283//cell proliferation;GO:0012502//induction of programmed cell death;GO:0040008//regulation of growth gi|109715844|ref|NP_612122.2|/0/bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform a [Homo sapiens] 8515 5189 76 608 0.323514097 1.72333778 2.41330502 Up 3.19E-63 5.17E-62 ITGA10 3 GO:0005887//integral to plasma membrane GO:0004871//signal transducer activity;GO:0005515//protein binding GO:0007166//cell surface receptor signaling pathway;GO:0031589//cell-substrate adhesion "gi|119591830|gb|EAW71424.1|/0/integrin, alpha 10, isoform CRA_a [Homo sapiens]" 83850 4449 4 32 0.01985916 0.105788406 2.41330502 Up 0.000196525 0.000451786 ESYT3 3 GO:0031224//intrinsic to membrane - - gi|103472031|ref|NP_114119.2|/0/extended synaptotagmin-3 [Homo sapiens] 122970 1703 4 32 0.051881035 0.276366775 2.41330502 Up 0.000196525 0.00045184 ACOT4 3 GO:0042579//microbody - GO:0006732//coenzyme metabolic process;GO:0046459//short-chain fatty acid metabolic process gi|187761341|ref|NP_689544.3|/0/acyl-coenzyme A thioesterase 4 [Homo sapiens] 84519 1886 6 48 0.070270469 0.374326048 2.41330502 Up 3.95E-06 1.08E-05 ACRBP 2 GO:0030141//secretory granule - - gi|17999524|ref|NP_115878.2|/0/acrosin-binding protein precursor [Homo sapiens] 171169 978 7 56 0.158096579 0.842169817 2.41330502 Up 5.71E-07 1.67E-06 SPACA4 2 GO:0030141//secretory granule;GO:0031224//intrinsic to membrane - GO:0009987//cellular process gi|19424138|ref|NP_598005.1|/9.60853e-51/sperm acrosome membrane-associated protein 4 precursor [Homo sapiens] 729689 790 8 64 0.2236795 1.191525615 2.41330502 Up 8.34E-08 2.60E-07 FAM90A2P 1 - GO:0005488//binding - gi|206558319|sp|Q658T7.2|F90A2_HUMAN/1.46518e-106/RecName: Full=Putative protein FAM90A2P 285676 2172 4 32 0.040678362 0.216690892 2.41330502 Up 0.000196525 0.000451731 ZNF454 1 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding "GO:0006351//transcription, DNA-dependent" gi|296010893|ref|NP_872400.2|/0/zinc finger protein 454 [Homo sapiens]//gi|390459538|ref|XP_003732332.1|/0/PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100395167 [Callithrix jacchus] 1235 3479 10 80 0.063490516 0.338209699 2.41330502 Up 1.82E-09 6.34E-09 CCR6 5 GO:0016021//integral to membrane GO:0004950//chemokine receptor activity GO:0006952//defense response;GO:0006955//immune response;GO:0007166//cell surface receptor signaling pathway;GO:0042221//response to chemical stimulus;GO:0051480//cytosolic calcium ion homeostasis gi|158259491|dbj|BAF85704.1|/0/unnamed protein product [Homo sapiens] 54716 5455 7 56 0.028344355 0.150988466 2.41330502 Up 5.71E-07 1.67E-06 SLC6A20 3 GO:0016021//integral to membrane;GO:0044459//plasma membrane part GO:0005275//amine transmembrane transporter activity;GO:0005326//neurotransmitter transporter activity;GO:0015291//secondary active transmembrane transporter activity GO:0006807//nitrogen compound metabolic process;GO:0015804//neutral amino acid transport;GO:0035725//sodium ion transmembrane transport gi|12408638|ref|NP_071800.1|/0/sodium- and chloride-dependent transporter XTRP3 isoform 2 [Homo sapiens]//gi|18568111|gb|AAL75944.1|AF125107_1/0/neurotransmitter transporter RB21A [Homo sapiens] 284085 1950 10 79 0.113273593 0.595858282 2.395157674 Up 2.70E-09 9.32E-09 KRT18P55 1 GO:0005813//centrosome;GO:0005882//intermediate filament GO:0005488//binding GO:0006915//apoptotic process;GO:0019221//cytokine-mediated signaling pathway;GO:0032502//developmental process;GO:0043001//Golgi to plasma membrane protein transport;GO:0051704 "gi|109067677|ref|XP_001098060.1|/1.50544e-157/PREDICTED: keratin, type I cytoskeletal 18 [Macaca mulatta]" 116842 707 16 126 0.499877808 2.621208886 2.390584944 Up 4.53E-14 2.04E-13 LEAP2 2 - - GO:0006952//defense response gi|16418465|ref|NP_443203.1|/2.36456e-38/liver-expressed antimicrobial peptide 2 precursor [Homo sapiens] 100652770 2000 8 63 0.088353402 0.463298671 2.390584944 Up 1.24E-07 3.81E-07 LOC100652770 1 GO:0005911//cell-cell junction;GO:0031224//intrinsic to membrane GO:0046872//metal ion binding GO:0006915//apoptotic process;GO:0016337//cell-cell adhesion gi|355754963|gb|EHH58830.1|/2.17319e-25/HDGC [Macaca fascicularis] 285759 2006 7 55 0.077077993 0.403257321 2.387309812 Up 8.51E-07 2.45E-06 FLJ34503 1 - - - gi|21750285|dbj|BAC03756.1|/6.68744e-75/unnamed protein product [Homo sapiens] 123872 2451 4 31 0.0360479 0.186023959 2.367501331 Up 0.000293672 0.000660606 DNAAF1 4 GO:0005819//spindle;GO:0005930//axoneme GO:0005515//protein binding GO:0043623//cellular protein complex assembly;GO:0048858//cell projection morphogenesis "gi|157674358|ref|NP_848547.4|/0/dynein assembly factor 1, axonemal [Homo sapiens]" 1638 2403 12 93 0.110303873 0.56921938 2.367501331 Up 1.32E-10 4.92E-10 DCT 1 GO:0030659//cytoplasmic vesicle membrane;GO:0031224//intrinsic to membrane;GO:0042598;GO:0048770 "GO:0016863//intramolecular oxidoreductase activity, transposing C=C bonds;GO:0046914//transition metal ion binding" GO:0006570//tyrosine metabolic process;GO:0006582//melanin metabolic process;GO:0009888//tissue development gi|193788640|ref|NP_001123361.1|/0/L-dopachrome tautomerase isoform 2 precursor [Homo sapiens]//gi|6041667|ref|NP_001913.2|/0/L-dopachrome tautomerase isoform 1 precursor [Homo sapiens] 6999 1703 4 31 0.051881035 0.267730313 2.367501331 Up 0.000293672 0.000660528 TDO2 3 GO:0000267//cell fraction;GO:0044444//cytoplasmic part "GO:0005506//iron ion binding;GO:0016702//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0031406//carboxylic acid binding" GO:0006084//acetyl-CoA metabolic process;GO:0006569//tryptophan catabolic process "gi|5032165|ref|NP_005642.1|/0/tryptophan 2,3-dioxygenase [Homo sapiens]" 170392 2361 4 31 0.037422026 0.193115088 2.367501331 Up 0.000293672 0.00066045 OIT3 1 GO:0012505//endomembrane system;GO:0043231//intracellular membrane-bounded organelle GO:0046872//metal ion binding - gi|22749297|ref|NP_689848.1|/0/oncoprotein-induced transcript 3 protein precursor [Homo sapiens] 229 2426 9 69 0.081943593 0.41832016 2.351904476 Up 4.02E-08 1.28E-07 ALDOB 3 GO:0000323//lytic vacuole;GO:0005789//endoplasmic reticulum membrane;GO:0005813//centrosome;GO:0042598 GO:0005543//phospholipid binding;GO:0016832//aldehyde-lyase activity;GO:0019899//enzyme binding;GO:0048029//monosaccharide binding GO:0001101//response to acid;GO:0006000//fructose metabolic process;GO:0006007//glucose catabolic process;GO:0006950//response to stress;GO:0007154//cell communication;GO:0009746;GO:0010038//response to metal ion;GO:0031960//response to corticosteroid stimulus;GO:0032868//response to insulin stimulus;GO:0034097//response to cytokine stimulus;GO:0043462//regulation of ATPase activity;GO:0048513//organ development;GO:0055114//oxidation-reduction process;GO:0070070//proton-transporting V-type ATPase complex assembly gi|40354205|ref|NP_000026.2|/0/fructose-bisphosphate aldolase B [Homo sapiens] 169270 2890 83 625 0.634371315 3.18077299 2.325977969 Up 2.71E-62 4.32E-61 ZNF596 1 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding "GO:0006351//transcription, DNA-dependent" gi|109240540|ref|NP_775810.2|/0/zinc finger protein 596 [Homo sapiens] 644890 638 4 30 0.138484957 0.691593776 2.320195616 Up 0.000437526 0.00096283 MEIG1 2 GO:0043231//intracellular membrane-bounded organelle - - gi|119606652|gb|EAW86246.1|/8.73673e-52/hCG2039913 [Homo sapiens] 653404 2725 4 30 0.032423267 0.161921772 2.320195616 Up 0.000437526 0.000963053 FOXD4L6 1 GO:0031981//nuclear lumen;GO:0043234//protein complex GO:0000981//sequence-specific DNA binding RNA polymerase II transcription factor activity;GO:0005515//protein binding;GO:0043565//sequence-specific DNA binding;GO:0043566//structure-specific DNA binding GO:0000122//negative regulation of transcription from RNA polymerase II promoter;GO:0001667//ameboidal cell migration;GO:0001822//kidney development;GO:0021782//glial cell development;GO:0030509//BMP signaling pathway;GO:0048675//axon extension;GO:0050931//pigment cell differentiation;GO:0060600 gi|34596581|gb|AAQ76878.1|/0/FOXD4 [Homo sapiens] 286059 2636 10 75 0.083794957 0.418471955 2.320195616 Up 1.30E-08 4.30E-08 LOC286059 1 - - - gi|119584043|gb|EAW63639.1|/3.18285e-51/hCG1994826 [Homo sapiens] 150368 2369 8 60 0.074591306 0.372508931 2.320195616 Up 4.05E-07 1.20E-06 FAM109B 2 GO:0005768//endosome;GO:0030135//coated vesicle - - gi|115583657|ref|NP_001002034.2|/1.08092e-127/sesquipedalian-2 [Homo sapiens] 400500 1314 4 30 0.067240032 0.335796674 2.320195616 Up 0.000437526 0.000962608 BCAR4 1 - - - "gi|119605542|gb|EAW85136.1|/1.06827e-61/hCG1814062, isoform CRA_a [Homo sapiens]//gi|119605542|gb|EAW85136.1|/3.17687e-61/hCG1814062, isoform CRA_a [Homo sapiens]" 387700 4622 4 30 0.019115838 0.095464481 2.320195616 Up 0.000437526 0.000962941 SLC16A12 3 GO:0031224//intrinsic to membrane GO:0015291//secondary active transmembrane transporter activity GO:0006810//transport gi|291621700|ref|NP_998771.3|/0/monocarboxylate transporter 12 [Homo sapiens] 2516 3095 4 30 0.028547141 0.142564404 2.320195616 Up 0.000437526 0.000962719 NR5A1 4 GO:0031981//nuclear lumen GO:0001071//nucleic acid binding transcription factor activity;GO:0003712//transcription cofactor activity;GO:0004879//ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity;GO:0005515//protein binding;GO:0008289//lipid binding;GO:0043566//structure-specific DNA binding;GO:0046914//transition metal ion binding GO:0006694//steroid biosynthetic process;GO:0007154//cell communication;GO:0008584//male gonad development;GO:0008585//female gonad development;GO:0009755//hormone-mediated signaling pathway;GO:0022602//ovulation cycle process;GO:0035270//endocrine system development;GO:0048869//cellular developmental process;GO:0072595 gi|20070193|ref|NP_004950.2|/0/steroidogenic factor 1 [Homo sapiens] 1137 5568 6 45 0.023802102 0.11886768 2.320195616 Up 1.30E-05 3.37E-05 CHRNA4 1 GO:0005626//insoluble fraction;GO:0005887//integral to plasma membrane;GO:0009986//cell surface;GO:0043005//neuron projection;GO:0044297//cell body GO:0004888//transmembrane signaling receptor activity;GO:0005231//excitatory extracellular ligand-gated ion channel activity;GO:0042165//neurotransmitter binding GO:0006259//DNA metabolic process;GO:0006950//response to stress;GO:0007600//sensory perception;GO:0010646//regulation of cell communication;GO:0014070//response to organic cyclic compound;GO:0030534//adult behavior;GO:0046649//lymphocyte activation;GO:0060078//regulation of postsynaptic membrane potential;GO:0070838//divalent metal ion transport "gi|4502827|ref|NP_000735.1|/0/neuronal acetylcholine receptor subunit alpha-4 isoform 1 precursor [Homo sapiens]//gi|64654852|gb|AAH96290.1|/0/Cholinergic receptor, nicotinic, alpha 4 [Homo sapiens]" 6447 1244 13 97 0.230826815 1.146837418 2.312778144 Up 9.42E-11 3.55E-10 SCG5 1 GO:0016023//cytoplasmic membrane-bounded vesicle GO:0005515//protein binding;GO:0030234//enzyme regulator activity;GO:0032561//guanyl ribonucleotide binding GO:0007186//G-protein coupled receptor signaling pathway;GO:0010646//regulation of cell communication;GO:0015031//protein transport gi|221139785|ref|NP_001138229.1|/1.21797e-115/neuroendocrine protein 7B2 isoform 1 precursor [Homo sapiens]//gi|4506917|ref|NP_003011.1|/3.5311e-115/neuroendocrine protein 7B2 isoform 2 precursor [Homo sapiens] 29881 5066 22 164 0.095922565 0.476133965 2.311425406 Up 2.72E-17 1.42E-16 NPC1L1 1 GO:0012506//vesicle membrane;GO:0031224//intrinsic to membrane;GO:0044459//plasma membrane part GO:0004888//transmembrane signaling receptor activity;GO:0015248//sterol transporter activity GO:0008203//cholesterol metabolic process;GO:0030301//cholesterol transport;GO:0044260;GO:0055092//sterol homeostasis gi|156231351|ref|NP_037521.2|/0/Niemann-Pick C1-like protein 1 isoform 1 precursor [Homo sapiens]//gi|156231353|ref|NP_001095118.1|/0/Niemann-Pick C1-like protein 1 isoform 2 precursor [Homo sapiens] 155054 3244 243 1810 1.654583601 8.206315874 2.310266499 Up 9.05E-176 4.39E-174 ZNF425 2 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding "GO:0006351//transcription, DNA-dependent" gi|119600467|gb|EAW80061.1|/0/zinc finger protein 425 [Homo sapiens] 151835 2066 9 67 0.096222244 0.476974307 2.309469209 Up 8.80E-08 2.74E-07 CPNE9 2 - - - gi|387539560|gb|AFJ70407.1|/0/copine-9 [Macaca mulatta] 973 1258 9 67 0.158024766 0.783329824 2.309469209 Up 8.80E-08 2.74E-07 CD79A 3 GO:0005770//late endosome;GO:0009986//cell surface;GO:0019814;GO:0031224//intrinsic to membrane GO:0004872//receptor activity GO:0030098//lymphocyte differentiation;GO:0042113//B cell activation;GO:0050851//antigen receptor-mediated signaling pathway gi|11038672|ref|NP_067612.1|/3.15204e-99/B-cell antigen receptor complex-associated protein alpha chain isoform 2 precursor [Homo sapiens]//gi|4502685|ref|NP_001774.1|/1.31377e-133/B-cell antigen receptor complex-associated protein alpha chain isoform 1 precursor [Homo sapiens] 5724 4318 98 729 0.501310412 2.483106751 2.308370181 Up 9.28E-72 1.72E-70 PTAFR 2 GO:0016021//integral to membrane;GO:0031981//nuclear lumen GO:0001530//lipopolysaccharide binding;GO:0004930//G-protein coupled receptor activity;GO:0008289//lipid binding GO:0002237//response to molecule of bacterial origin;GO:0002376//immune system process;GO:0006952//defense response;GO:0019221//cytokine-mediated signaling pathway;GO:0022414//reproductive process;GO:0032501//multicellular organismal process;GO:0032957//inositol trisphosphate metabolic process;GO:0048017//inositol lipid-mediated signaling gi|4506241|ref|NP_000943.1|/5.21622e-176/platelet-activating factor receptor [Homo sapiens]//gi|4506241|ref|NP_000943.1|/5.33119e-176/platelet-activating factor receptor [Homo sapiens]//gi|4506241|ref|NP_000943.1|/5.4121e-176/platelet-activating factor receptor [Homo sapiens]//gi|4506241|ref|NP_000943.1|/5.48926e-176/platelet-activating factor receptor [Homo sapiens] 138724 3406 5 37 0.032425647 0.159774542 2.300830291 Up 9.10E-05 0.000217345 C9orf131 1 - - - gi|94536860|ref|NP_001035500.1|/0/uncharacterized protein C9orf131 isoform B [Homo sapiens]//gi|94536862|ref|NP_001035501.1|/0/uncharacterized protein C9orf131 isoform C [Homo sapiens]//gi|94536864|ref|NP_001035502.1|/0/uncharacterized protein C9orf131 isoform D [Homo sapiens]//gi|94681096|ref|NP_976044.2|/0/uncharacterized protein C9orf131 isoform A [Homo sapiens] 4438 3293 64 473 0.42929075 2.112612817 2.299001394 Up 6.67E-47 8.00E-46 MSH4 3 GO:0000794//condensed nuclear chromosome;GO:0043234//protein complex "GO:0003690//double-stranded DNA binding;GO:0032559;GO:0042623//ATPase activity, coupled" GO:0006298//mismatch repair;GO:0006310//DNA recombination;GO:0007127//meiosis I;GO:0009207;GO:0022602//ovulation cycle process;GO:0048232//male gamete generation gi|36949366|ref|NP_002431.2|/0/mutS protein homolog 4 [Homo sapiens] 204219 3894 6 44 0.034034439 0.166190896 2.287774138 Up 1.92E-05 4.90E-05 CERS3 3 GO:0005635//nuclear envelope;GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane GO:0001071//nucleic acid binding transcription factor activity;GO:0003677//DNA binding;GO:0016410//N-acyltransferase activity "GO:0006351//transcription, DNA-dependent;GO:0006665//sphingolipid metabolic process" gi|116235446|ref|NP_849164.2|/0/ceramide synthase 3 [Homo sapiens] 84163 3551 12 88 0.074643821 0.364487384 2.287774138 Up 9.27E-10 3.29E-09 GTF2IRD2 2 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding - gi|48762700|ref|NP_775808.2|/0/general transcription factor II-I repeat domain-containing protein 2A [Homo sapiens] 286006 1686 32 232 0.419233226 2.023862087 2.271286016 Up 1.95E-23 1.27E-22 C7orf53 1 GO:0031224//intrinsic to membrane - - gi|32699019|ref|NP_872403.1|/2.67887e-51/coiled-coil domain-containing transmembrane protein C7orf53 [Homo sapiens]//gi|32699019|ref|NP_872403.1|/3.16998e-51/coiled-coil domain-containing transmembrane protein C7orf53 [Homo sapiens] 201625 9542 9 65 0.020833699 0.100190016 2.265747832 Up 1.91E-07 5.80E-07 DNAH12 3 GO:0005875//microtubule associated complex;GO:0005930//axoneme GO:0003774//motor activity;GO:0032559 GO:0007017//microtubule-based process "gi|194440727|ref|NP_848599.3|/0/dynein heavy chain 12, axonemal isoform 1 [Homo sapiens]//gi|89274173|ref|NP_940966.2|/0/dynein heavy chain 12, axonemal isoform 2 [Homo sapiens]" 339290 3979 10 72 0.055512316 0.266139329 2.261301927 Up 4.17E-08 1.33E-07 LOC339290 1 - - - "gi|291394138|ref|XP_002713630.1|/5.15432e-28/PREDICTED: leucine zipper, down-regulated in cancer 1-like [Oryctolagus cuniculus]" 9075 3163 10 72 0.069833546 0.334798732 2.261301927 Up 4.17E-08 1.33E-07 CLDN2 1 GO:0031224//intrinsic to membrane;GO:0043296//apical junction complex GO:0005515//protein binding GO:0016337//cell-cell adhesion gi|9966781|ref|NP_065117.1|/5.47873e-92/claudin-2 [Homo sapiens]//gi|9966781|ref|NP_065117.1|/5.62308e-92/claudin-2 [Homo sapiens]//gi|9966781|ref|NP_065117.1|/5.98396e-92/claudin-2 [Homo sapiens] 115111 5280 10 72 0.041833997 0.200562195 2.261301927 Up 4.17E-08 1.33E-07 SLC26A7 2 GO:0010008//endosome membrane;GO:0031224//intrinsic to membrane;GO:0044459//plasma membrane part GO:0005253//anion channel activity;GO:0005310//dicarboxylic acid transmembrane transporter activity;GO:0015103//inorganic anion transmembrane transporter activity GO:0006835//dicarboxylic acid transport;GO:0015698//inorganic anion transport gi|16306483|ref|NP_439897.1|/0/anion exchange transporter isoform a [Homo sapiens]//gi|20336282|ref|NP_599028.1|/0/anion exchange transporter isoform b [Homo sapiens] 92162 887 5 36 0.124511559 0.596938213 2.261301927 Up 0.000134696 0.000315084 TMEM88 1 - - - gi|44662813|ref|NP_981956.1|/2.48091e-31/transmembrane protein 88 [Homo sapiens] 347744 701 28 201 0.882273634 4.217242162 2.25700179 Up 2.39E-20 1.40E-19 C6orf52 1 - - - "gi|119575668|gb|EAW55264.1|/6.76315e-89/hCG1792372, isoform CRA_a [Homo sapiens]//gi|55958879|emb|CAI14001.1|/1.44356e-64/chromosome 6 open reading frame 52 [Homo sapiens]//gi|55958879|emb|CAI14001.1|/2.88893e-73/chromosome 6 open reading frame 52 [Homo sapiens]" 345079 2921 12 86 0.090742967 0.433029411 2.254607274 Up 2.01E-09 6.98E-09 SOWAHB 1 - - - gi|71274172|ref|NP_001025041.1|/0/ankyrin repeat domain-containing protein SOWAHB [Homo sapiens] 284440 2385 13 93 0.120397718 0.573515375 2.252024113 Up 4.42E-10 1.60E-09 LOC284440 1 - - - gi|119605265|gb|EAW84859.1|/3.97107e-45/hCG2001421 [Homo sapiens] 100526835 2799 4 34 0.03156606 0.150260939 2.251023915 Up 8.73E-05 0.000209054 FPGT-TNNI3K 1 GO:0043231//intracellular membrane-bounded organelle GO:0004672//protein kinase activity;GO:0008092//cytoskeletal protein binding;GO:0032559;GO:0043169//cation binding GO:0006464//cellular protein modification process gi|313569861|ref|NP_001186256.1|/0/FPGT-TNNI3K fusion protein isoform b [Homo sapiens]//gi|62087462|dbj|BAD92178.1|/0/TNNI3 interacting kinase variant [Homo sapiens] 4807 2594 29 207 0.246939926 1.173683162 2.248810983 Up 7.88E-21 4.73E-20 NHLH1 3 - - GO:0032502//developmental process gi|344237291|gb|EGV93394.1|/1.90751e-24/Helix-loop-helix protein 1 [Cricetulus griseus] 51555 9205 23 164 0.055190882 0.262041789 2.247295069 Up 9.00E-17 4.59E-16 PEX5L 1 GO:0030427//site of polarized growth;GO:0034703//cation channel complex;GO:0043005//neuron projection;GO:0044424//intracellular part;GO:0044439 GO:0000268//peroxisome targeting sequence binding;GO:0005083//small GTPase regulator activity;GO:0005217//intracellular ligand-gated ion channel activity GO:0006625//protein targeting to peroxisome;GO:0006811//ion transport;GO:0006873//cellular ion homeostasis;GO:0006887//exocytosis;GO:0009966//regulation of signal transduction;GO:0019222//regulation of metabolic process;GO:0046887//positive regulation of hormone secretion;GO:0051235 gi|377520115|ref|NP_001243679.1|/0/PEX5-related protein isoform 2 [Homo sapiens]//gi|377520117|ref|NP_001243680.1|/0/PEX5-related protein isoform 3 [Homo sapiens]//gi|377520119|ref|NP_001243681.1|/0/PEX5-related protein isoform 4 [Homo sapiens]//gi|377520121|ref|NP_001243682.1|/0/PEX5-related protein isoform 5 [Homo sapiens]//gi|377520125|ref|NP_001243684.1|/0/PEX5-related protein isoform 7 [Homo sapiens]//gi|7706671|ref|NP_057643.1|/0/PEX5-related protein isoform 1 [Homo sapiens] 7018 2808 8 57 0.062929774 0.298557684 2.246195035 Up 1.30E-06 3.69E-06 TF 3 GO:0005768//endosome;GO:0012505//endomembrane system;GO:0016023//cytoplasmic membrane-bounded vesicle;GO:0016323//basolateral plasma membrane;GO:0031090//organelle membrane GO:0005506//iron ion binding;GO:0019899//enzyme binding GO:0000041//transition metal ion transport;GO:0001775//cell activation;GO:0006875//cellular metal ion homeostasis;GO:0006887//exocytosis;GO:0007599//hemostasis;GO:0015031//protein transport "gi|380258836|pdb|3QYT|A/0/Chain A, Diferric Bound Human Serum Transferrin" 125050 332 85 604 5.655150008 26.75773542 2.242318824 Up 9.27E-58 1.38E-56 RN7SK 2 GO:0044444//cytoplasmic part "GO:0016763//transferase activity, transferring pentosyl groups;GO:0042802//identical protein binding;GO:0046872//metal ion binding" GO:0006177//GMP biosynthetic process;GO:0006188//IMP biosynthetic process;GO:0007610//behavior;GO:0008219//cell death;GO:0009169;GO:0014075//response to amine stimulus;GO:0021544//subpallium development;GO:0021953//central nervous system neuron differentiation;GO:0032943//mononuclear cell proliferation;GO:0042053//regulation of dopamine metabolic process;GO:0043096//purine nucleobase salvage;GO:0048812//neuron projection morphogenesis gi|332831420|ref|XP_003312023.1|/1.1858e-24/PREDICTED: hypothetical protein LOC100608461 [Pan troglodytes] 387644 3650 28 198 0.169444881 0.797852897 2.235306718 Up 7.50E-20 4.31E-19 LINC00202 1 GO:0005924//cell-substrate adherens junction;GO:0031252//cell leading edge;GO:0043232;GO:0044444//cytoplasmic part - GO:0007599//hemostasis;GO:0023052//signaling "gi|119606482|gb|EAW86076.1|/7.58121e-54/hCG1783738, isoform CRA_b [Homo sapiens]" 8639 4040 116 817 0.634219968 2.974343972 2.229516293 Up 4.98E-77 9.97E-76 AOC3 2 GO:0031224//intrinsic to membrane "GO:0016641//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor;GO:0042802//identical protein binding;GO:0046914//transition metal ion binding;GO:0048037//cofactor binding" GO:0006807//nitrogen compound metabolic process;GO:0006952//defense response;GO:0009987//cellular process gi|4502119|ref|NP_003725.1|/0/membrane primary amine oxidase [Homo sapiens] 2056 1340 8 56 0.13187075 0.61465827 2.220659942 Up 1.91E-06 5.35E-06 EPO 2 GO:0044421//extracellular region part GO:0005126//cytokine receptor binding GO:0002237//response to molecule of bacterial origin;GO:0003013;GO:0006275//regulation of DNA replication;GO:0006970//response to osmotic stress;GO:0008283//cell proliferation;GO:0009611//response to wounding;GO:0020027//hemoglobin metabolic process;GO:0030099//myeloid cell differentiation;GO:0033273//response to vitamin;GO:0034097//response to cytokine stimulus;GO:0042506//tyrosine phosphorylation of Stat5 protein;GO:0043523//regulation of neuron apoptotic process;GO:0045597//positive regulation of cell differentiation;GO:0046578//regulation of Ras protein signal transduction;GO:0048469//cell maturation;GO:0048545//response to steroid hormone stimulus gi|62240997|ref|NP_000790.2|/3.46768e-79/erythropoietin precursor [Homo sapiens] 8022 2419 7 49 0.063918336 0.297927582 2.220659942 Up 8.90E-06 2.34E-05 LHX3 3 GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex GO:0001071//nucleic acid binding transcription factor activity;GO:0003677//DNA binding;GO:0046914//transition metal ion binding GO:0003002//regionalization;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0006915//apoptotic process;GO:0007411//axon guidance;GO:0021523//somatic motor neuron differentiation;GO:0021536//diencephalon development gi|30023847|ref|NP_835258.1|/0/LIM/homeobox protein Lhx3 isoform a [Homo sapiens]//gi|7657303|ref|NP_055379.1|/0/LIM/homeobox protein Lhx3 isoform b [Homo sapiens] 80270 2233 140 978 1.384849569 6.441702029 2.217712658 Up 2.68E-91 6.40E-90 HSD3B7 3 GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0042598;GO:0043231//intracellular membrane-bounded organelle "GO:0033764//steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" GO:0006694//steroid biosynthetic process;GO:0016049//cell growth "gi|149067682|gb|EDM17234.1|/1.35061e-127/hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7, isoform CRA_d [Rattus norvegicus]//gi|149067682|gb|EDM17234.1|/1.51015e-127/hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7, isoform CRA_d [Rattus norvegicus]//gi|19923621|ref|NP_079469.2|/0/3 beta-hydroxysteroid dehydrogenase type 7 isoform a [Homo sapiens]" 153770 725 10 69 0.304666905 1.399785803 2.199901382 Up 1.32E-07 4.04E-07 PLAC8L1 1 - - - gi|71274180|ref|NP_001025040.1|/8.88621e-105/PLAC8-like protein 1 [Homo sapiens] 152831 6079 45 310 0.163509751 0.750032445 2.197576329 Up 1.07E-29 8.60E-29 KLB 3 GO:0031224//intrinsic to membrane "GO:0016798//hydrolase activity, acting on glycosyl bonds;GO:0019838//growth factor binding;GO:0043167//ion binding" GO:0008283//cell proliferation;GO:0008543//fibroblast growth factor receptor signaling pathway;GO:0044238//primary metabolic process gi|28376633|ref|NP_783864.1|/0/beta-klotho [Homo sapiens] 200958 6462 21 143 0.071782012 0.32547646 2.180858934 Up 2.56E-14 1.17E-13 MUC20 2 - - - gi|149193325|ref|NP_689886.2|/0/mucin-20 isoform L precursor [Homo sapiens] 1586 1895 5 34 0.058280608 0.263888341 2.178839767 Up 0.000292672 0.000658512 CYP17A1 3 GO:0031090//organelle membrane;GO:0043005//neuron projection;GO:0043231//intracellular membrane-bounded organelle;GO:0044297//cell body GO:0005506//iron ion binding;GO:0008395//steroid hydroxylase activity GO:0003006//developmental process involved in reproduction;GO:0006700//C21-steroid hormone biosynthetic process;GO:0010033//response to organic substance;GO:0033189//response to vitamin A "gi|4503195|ref|NP_000093.1|/0/steroid 17-alpha-hydroxylase/17,20 lyase precursor [Homo sapiens]" 100506082 463 9 61 0.429363187 1.937757133 2.174117357 Up 8.88E-07 2.55E-06 LOC100506082 1 - - - gi|119622989|gb|EAX02584.1|/7.401e-37/hCG2040648 [Homo sapiens] 114898 2411 13 88 0.11909936 0.536828992 2.172296921 Up 2.97E-09 1.02E-08 C1QTNF2 4 GO:0044421//extracellular region part GO:0005515//protein binding GO:0000165//MAPK cascade;GO:0005979//regulation of glycogen biosynthetic process;GO:0010828//positive regulation of glucose transport;GO:0045923//positive regulation of fatty acid metabolic process;GO:0051259//protein oligomerization "gi|380799161|gb|AFE71456.1|/3.98245e-77/complement C1q tumor necrosis factor-related protein 2, partial [Macaca mulatta]" 100505538 2484 110 744 0.978147572 4.405263029 2.171104118 Up 4.08E-68 7.11E-67 RBM26-AS1 1 - - - "gi|119601001|gb|EAW80595.1|/7.60817e-39/hCG1817733, isoform CRA_a [Homo sapiens]" 280 2215 79 534 0.787801218 3.545830952 2.170220204 Up 2.54E-49 3.20E-48 AMY2B 3 GO:0044421//extracellular region part GO:0016160//amylase activity;GO:0043168;GO:0046872//metal ion binding GO:0005975//carbohydrate metabolic process;GO:0007586//digestion gi|10280622|ref|NP_066188.1|/0/alpha-amylase 2B precursor [Homo sapiens] 5026 2341 8 54 0.075483471 0.339267959 2.168192523 Up 4.11E-06 1.12E-05 P2RX5 1 GO:0016021//integral to membrane GO:0005231//excitatory extracellular ligand-gated ion channel activity;GO:0016502;GO:0032559 GO:0009967//positive regulation of signal transduction;GO:0010522//regulation of calcium ion transport into cytosol;GO:0035587;GO:0048731 gi|62088826|dbj|BAD92860.1|/0/purinergic receptor P2X5 isoform A variant [Homo sapiens] 2660 2823 8 54 0.062595397 0.28134123 2.168192523 Up 4.11E-06 1.12E-05 MSTN 2 GO:0044421//extracellular region part;GO:0044424//intracellular part GO:0005102//receptor binding GO:0007178//transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0009628//response to abiotic stimulus;GO:0014743;GO:0014823//response to activity;GO:0014891;GO:0031960//response to corticosteroid stimulus;GO:0042246//tissue regeneration;GO:0042698//ovulation cycle;GO:0048631 gi|4885259|ref|NP_005250.1|/0/growth/differentiation factor 8 precursor [Homo sapiens] 339977 3348 66 443 0.435433435 1.946116242 2.16007379 Up 5.89E-41 6.27E-40 LRRC66 1 GO:0031224//intrinsic to membrane - - gi|66912176|ref|NP_001019782.1|/0/leucine-rich repeat-containing protein 66 [Homo sapiens] 344657 1825 10 67 0.121032058 0.539961051 2.157466116 Up 2.82E-07 8.43E-07 LRRIQ4 1 - - - gi|122937315|ref|NP_001073929.1|/0/leucine-rich repeat and IQ domain-containing protein 4 [Homo sapiens] 5913 1671 6 40 0.079311851 0.352074071 2.150270615 Up 9.01E-05 0.000215344 RAPSN 4 GO:0043231//intracellular membrane-bounded organelle;GO:0043232;GO:0044459//plasma membrane part;GO:0045202//synapse GO:0004871//signal transducer activity;GO:0005102//receptor binding;GO:0035254//glutamate receptor binding;GO:0046914//transition metal ion binding GO:0007267//cell-cell signaling;GO:0007268//synaptic transmission;GO:0043065//positive regulation of apoptotic process gi|15619013|ref|NP_005046.2|/0/43 kDa receptor-associated protein of the synapse isoform 1 [Homo sapiens]//gi|38045928|ref|NP_116034.2|/0/43 kDa receptor-associated protein of the synapse isoform 2 [Homo sapiens] 1133 3055 6 40 0.043381376 0.192574721 2.150270615 Up 9.01E-05 0.000215425 CHRM5 3 GO:0016021//integral to membrane;GO:0044459//plasma membrane part GO:0004629//phospholipase C activity;GO:0016907//G-protein coupled acetylcholine receptor activity GO:0007154//cell communication;GO:0007193//adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0019216//regulation of lipid metabolic process;GO:0051937 "gi|27469809|gb|AAH41805.1|/0/Cholinergic receptor, muscarinic 5 [Homo sapiens] " 283933 2013 15 100 0.164592777 0.730645519 2.150270615 Up 3.07E-10 1.12E-09 ZNF843 1 GO:0044464//cell part GO:0046914//transition metal ion binding - gi|119572521|gb|EAW52136.1|/0/hCG2042318 [Homo sapiens] 9074 1389 6 40 0.095414042 0.423553472 2.150270615 Up 9.01E-05 0.000215371 CLDN6 4 GO:0031224//intrinsic to membrane;GO:0043296//apical junction complex GO:0005515//protein binding GO:0016337//cell-cell adhesion gi|153792768|ref|NP_067018.2|/4.605e-90/claudin-6 precursor [Homo sapiens] 1244 5051 93 620 0.406695032 1.805364179 2.150270615 Up 2.20E-56 3.19E-55 ABCC2 3 GO:0005626//insoluble fraction;GO:0005911//cell-cell junction;GO:0016021//integral to membrane GO:0008509//anion transmembrane transporter activity;GO:0015405;GO:0017111//nucleoside-triphosphatase activity;GO:0032559 GO:0006820//anion transport;GO:0009207 gi|4557481|ref|NP_000383.1|/0/canalicular multispecific organic anion transporter 1 [Homo sapiens] 6580 1921 6 40 0.068990163 0.306254957 2.150270615 Up 9.01E-05 0.000215398 SLC22A1 2 GO:0005626//insoluble fraction;GO:0016021//integral to membrane;GO:0044459//plasma membrane part GO:0005488//binding;GO:0008324//cation transmembrane transporter activity GO:0006812//cation transport gi|23510410|ref|NP_694857.1|/0/solute carrier family 22 member 1 isoform b [Homo sapiens]//gi|4506999|ref|NP_003048.1|/0/solute carrier family 22 member 1 isoform a [Homo sapiens] 23109 3744 146 971 0.861351279 3.814467247 2.146807947 Up 3.40E-87 7.81E-86 DDN 1 GO:0030425//dendrite;GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0032589//neuron projection membrane;GO:0043025//neuronal cell body;GO:0043231//intracellular membrane-bounded organelle - - gi|194272140|ref|NP_055901.2|/0/dendrin [Homo sapiens] 5146 2980 5 33 0.037060991 0.162872655 2.135771045 Up 0.00042944 0.000946347 PDE6C 3 GO:0016020//membrane "GO:0004114//3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0019002//GMP binding;GO:0043169//cation binding" GO:0007602//phototransduction;GO:0042462//eye photoreceptor cell development;GO:0050953//sensory perception of light stimulus "gi|157364939|ref|NP_006195.3|/0/cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [Homo sapiens]" 145376 1405 5 33 0.07860623 0.345452322 2.135771045 Up 0.00042944 0.000946457 PPP1R36 1 - - - gi|27312029|ref|NP_758953.1|/0/protein phosphatase 1 regulatory subunit 36 [Homo sapiens] 11251 2910 10 66 0.075904985 0.333581108 2.135771045 Up 4.11E-07 1.21E-06 PTGDR2 2 GO:0016021//integral to membrane GO:0004955//prostaglandin receptor activity;GO:0008528//G-protein coupled peptide receptor activity GO:0002376//immune system process;GO:0007188//adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0008277//regulation of G-protein coupled receptor protein signaling pathway;GO:0042221//response to chemical stimulus gi|153791424|ref|NP_004769.2|/2.81128e-173/prostaglandin D2 receptor 2 [Homo sapiens] 645752 3117 14 92 0.099209788 0.434111734 2.129512054 Up 2.02E-09 7.02E-09 LOC645752 1 - - - gi|256542288|ref|NP_001157876.1|/0/putative golgin subfamily A member 6C [Homo sapiens] 8174 1546 7 46 0.100011937 0.437621693 2.129512054 Up 2.80E-05 7.03E-05 MADCAM1 2 GO:0005626//insoluble fraction;GO:0031224//intrinsic to membrane - GO:0002682//regulation of immune system process;GO:0002684//positive regulation of immune system process;GO:0009913//epidermal cell differentiation;GO:0023052//signaling gi|109633022|ref|NP_570116.2|/4.287e-132/mucosal addressin cell adhesion molecule 1 isoform a precursor [Homo sapiens]//gi|18780285|ref|NP_570118.1|/2.48432e-127/mucosal addressin cell adhesion molecule 1 isoform b precursor [Homo sapiens] 100316868 3772 59 385 0.34549647 1.501203422 2.119376607 Up 5.32E-35 4.90E-34 HOTTIP 2 - - - gi|119614297|gb|EAW93891.1|/1.38609e-42/hCG2009941 [Homo sapiens] 146177 4686 18 117 0.084846417 0.367226554 2.113744739 Up 1.50E-11 5.92E-11 VWA3A 3 - - - gi|218505703|ref|NP_775886.3|/0/von Willebrand factor A domain-containing protein 3A precursor [Homo sapiens] 26548 1235 46 299 0.822723991 3.560858622 2.113744739 Up 1.99E-27 1.49E-26 ITGB1BP2 1 GO:0031674//I band GO:0005102//receptor binding;GO:0019904//protein domain specific binding;GO:0046914//transition metal ion binding GO:0023052//signaling;GO:0048513//organ development gi|6912438|ref|NP_036410.1|/0/integrin beta-1-binding protein 2 [Homo sapiens] 57191 1566 8 52 0.112839594 0.488384741 2.113744739 Up 8.75E-06 2.30E-05 VN1R1 3 GO:0031224//intrinsic to membrane GO:0004930//G-protein coupled receptor activity GO:0010033//response to organic substance gi|10190668|ref|NP_065684.1|/0/vomeronasal type-1 receptor 1 [Homo sapiens] 3965 1835 14 90 0.168521476 0.721368113 2.097803195 Up 4.25E-09 1.45E-08 LGALS9 3 GO:0044424//intracellular part GO:0048029//monosaccharide binding;GO:0060089 GO:0007249//I-kappaB kinase/NF-kappaB cascade gi|102469694|ref|NP_002299.2|/4.69941e-159/galectin-9 isoform short [Homo sapiens]//gi|102469694|ref|NP_002299.2|/7.0936e-179/galectin-9 isoform short [Homo sapiens]//gi|6806890|ref|NP_033665.1|/0/galectin-9 isoform long [Homo sapiens] 58484 3385 62 397 0.404572449 1.724973128 2.092103907 Up 1.71E-35 1.60E-34 NLRC4 1 GO:0044424//intracellular part GO:0032559;GO:0042802//identical protein binding;GO:0046872//metal ion binding GO:0006952//defense response;GO:0009581//detection of external stimulus;GO:0042981//regulation of apoptotic process;GO:0050701//interleukin-1 secretion gi|40788015|ref|NP_067032.3|/0/NLR family CARD domain-containing protein 4 [Homo sapiens] 158511 885 11 70 0.274544471 1.163336273 2.083156419 Up 2.75E-07 8.24E-07 CSAG1 1 - - GO:0042221//response to chemical stimulus gi|24234760|ref|NP_705611.1|/2.90231e-40/putative chondrosarcoma-associated gene 1 protein [Homo sapiens]//gi|24234760|ref|NP_705611.1|/4.95705e-40/putative chondrosarcoma-associated gene 1 protein [Homo sapiens] 346288 3785 14 89 0.081700636 0.345839523 2.081683529 Up 6.16E-09 2.08E-08 14-Sep 2 GO:0032156 GO:0032561//guanyl ribonucleotide binding GO:0009987//cellular process gi|153252198|ref|NP_997249.2|/0/septin-14 [Homo sapiens] 100130522 3352 27 171 0.177919292 0.750313224 2.076270033 Up 5.89E-16 2.90E-15 PARD6G-AS1 1 - - - gi|119587052|gb|EAW66648.1|/2.01626e-29/hCG1996578 [Homo sapiens]//gi|119587052|gb|EAW66648.1|/5.47337e-25/hCG1996578 [Homo sapiens] 8521 2780 6 38 0.047672699 0.20104316 2.076270033 Up 0.000191998 0.000442339 GCM1 3 GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex GO:0001071//nucleic acid binding transcription factor activity;GO:0003676//nucleic acid binding;GO:0005515//protein binding;GO:0046914//transition metal ion binding "GO:0006351//transcription, DNA-dependent;GO:0021781//glial cell fate commitment;GO:0048598//embryonic morphogenesis" gi|45269133|ref|NP_003634.2|/0/chorion-specific transcription factor GCMa [Homo sapiens] 284013 821 6 38 0.161425218 0.680755157 2.076270033 Up 0.000191998 0.000442392 VMO1 1 - - GO:0048477//oogenesis gi|32698964|ref|NP_872372.1|/1.22752e-107/vitelline membrane outer layer protein 1 homolog isoform 1 precursor [Homo sapiens]//gi|32698964|ref|NP_872372.1|/2.26833e-113/vitelline membrane outer layer protein 1 homolog isoform 1 precursor [Homo sapiens]//gi|32698964|ref|NP_872372.1|/3.79818e-107/vitelline membrane outer layer protein 1 homolog isoform 1 precursor [Homo sapiens]//gi|32698964|ref|NP_872372.1|/6.79168e-88/vitelline membrane outer layer protein 1 homolog isoform 1 precursor [Homo sapiens] 84419 953 6 38 0.139066216 0.586463781 2.076270033 Up 0.000191998 0.000442285 C15orf48 2 GO:0043231//intracellular membrane-bounded organelle - - gi|14165280|ref|NP_115789.1|/1.18518e-40/normal mucosa of esophagus-specific gene 1 protein [Homo sapiens]//gi|14165280|ref|NP_115789.1|/1.47418e-40/normal mucosa of esophagus-specific gene 1 protein [Homo sapiens] 402573 1020 11 69 0.238207703 0.994945791 2.062397859 Up 3.98E-07 1.18E-06 C7orf61 1 - - - gi|51972226|ref|NP_001004323.1|/7.5423e-78/uncharacterized protein C7orf61 [Homo sapiens] 1959 2992 30 187 0.221474104 0.919243394 2.053308885 Up 4.20E-17 2.17E-16 EGR2 1 GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0001085//RNA polymerase II transcription factor binding;GO:0003676//nucleic acid binding;GO:0019899//enzyme binding;GO:0046872//metal ion binding;GO:0046914//transition metal ion binding "GO:0001503//ossification;GO:0006355//regulation of transcription, DNA-dependent;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0006366//transcription from RNA polymerase II promoter;GO:0007411//axon guidance;GO:0007422//peripheral nervous system development;GO:0007610//behavior;GO:0008366//axon ensheathment;GO:0019226//transmission of nerve impulse;GO:0021594//rhombomere formation;GO:0021604;GO:0022008//neurogenesis;GO:0042221//response to chemical stimulus;GO:0043434//response to peptide hormone stimulus;GO:0048167//regulation of synaptic plasticity;GO:0051239;GO:0065008" gi|9845524|ref|NP_000390.2|/0/E3 SUMO-protein ligase EGR2 isoform a [Homo sapiens] 177 1691 174 1083 2.272840336 9.419662646 2.051179052 Up 8.91E-92 2.15E-90 AGER 1 GO:0016021//integral to membrane GO:0004872//receptor activity;GO:0005515//protein binding GO:0006952//defense response;GO:0007165//signal transduction;GO:0030030//cell projection organization;GO:0051091//positive regulation of sequence-specific DNA binding transcription factor activity gi|194389738|dbj|BAG60385.1|/0/unnamed protein product [Homo sapiens]//gi|194389738|dbj|BAG60385.1|/1.59787e-173/unnamed protein product [Homo sapiens]//gi|194389738|dbj|BAG60385.1|/3.51944e-167/unnamed protein product [Homo sapiens]//gi|194389738|dbj|BAG60385.1|/7.70642e-175/unnamed protein product [Homo sapiens]//gi|194389738|dbj|BAG60385.1|/8.44856e-175/unnamed protein product [Homo sapiens]//gi|26787962|ref|NP_751947.1|/5.8537e-159/advanced glycosylation end product-specific receptor isoform 7 precursor [Homo sapiens]//gi|332800965|ref|NP_001193858.1|/0/advanced glycosylation end product-specific receptor isoform 2 precursor [Homo sapiens]//gi|332800969|ref|NP_001193863.1|/0/advanced glycosylation end product-specific receptor isoform 4 precursor [Homo sapiens]//gi|332800971|ref|NP_001193865.1|/0/advanced glycosylation end product-specific receptor isoform 5 precursor [Homo sapiens]//gi|332800985|ref|NP_001193883.1|/1.2976e-179/advanced glycosylation end product-specific receptor isoform 8 precursor [Homo sapiens] 84941 2369 18 112 0.167830439 0.695350005 2.050734941 Up 9.45E-11 3.56E-10 HSH2D 2 GO:0043231//intracellular membrane-bounded organelle "GO:0030674//protein binding, bridging" GO:0046649//lymphocyte activation gi|14249584|ref|NP_116244.1|/0/hematopoietic SH2 domain-containing protein [Homo sapiens] 374286 2780 42 261 0.333708894 1.38084907 2.048893594 Up 2.92E-23 1.89E-22 CDRT1 3 - - - gi|157694487|ref|NP_006373.2|/0/CMT1A duplicated region transcript 1 protein [Homo sapiens] 374768 1009 10 62 0.218913287 0.903755646 2.045573236 Up 1.82E-06 5.11E-06 SPEM1 2 GO:0016020//membrane - GO:0032501//multicellular organismal process;GO:0032502//developmental process gi|116268095|ref|NP_955371.2|/3.05074e-140/spermatid maturation protein 1 [Homo sapiens] 51364 1780 65 402 0.806597073 3.321670512 2.041988899 Up 6.87E-35 6.31E-34 ZMYND10 2 GO:0044424//intracellular part GO:0046914//transition metal ion binding - gi|37594444|ref|NP_056980.2|/0/zinc finger MYND domain-containing protein 10 [Homo sapiens] 161247 1064 6 37 0.124558368 0.511458731 2.037795885 Up 0.00027903 0.00062908 FITM1 2 GO:0031090//organelle membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0044425//membrane part - GO:0006996//organelle organization;GO:0010884//positive regulation of lipid storage gi|42822882|ref|NP_981947.1|/3.1218e-122/fat storage-inducing transmembrane protein 1 [Homo sapiens] 400999 514 6 37 0.257840669 1.058739473 2.037795885 Up 0.00027903 0.000629155 FLJ42351 1 - - - - 50856 1284 7 43 0.120419357 0.492554093 2.032214853 Up 8.60E-05 0.000206246 CLEC4A 2 GO:0016021//integral to membrane GO:0004872//receptor activity;GO:0030246//carbohydrate binding GO:0006952//defense response;GO:0007165//signal transduction gi|148536836|ref|NP_919429.2|/4.51976e-117/C-type lectin domain family 4 member A isoform 3 [Homo sapiens]//gi|37577117|ref|NP_919430.1|/2.0468e-97/C-type lectin domain family 4 member A isoform 4 [Homo sapiens]//gi|37577119|ref|NP_919432.1|/6.22027e-106/C-type lectin domain family 4 member A isoform 2 [Homo sapiens]//gi|7705338|ref|NP_057268.1|/8.24206e-123/C-type lectin domain family 4 member A isoform 1 [Homo sapiens] 347736 2133 7 43 0.072488727 0.296502323 2.032214853 Up 8.60E-05 0.00020622 NME9 2 GO:0043232 "GO:0016776//phosphotransferase activity, phosphate group as acceptor;GO:0032559" GO:0009206;GO:0009209;GO:0019725//cellular homeostasis gi|30023828|ref|NP_835231.1|/6.79326e-150/thioredoxin domain-containing protein 6 [Homo sapiens] 152206 2847 26 159 0.201720097 0.821410325 2.025748258 Up 1.62E-14 7.42E-14 CCDC13 3 - - - gi|154090997|ref|NP_653320.3|/0/coiled-coil domain-containing protein 13 [Homo sapiens] 142680 2180 9 55 0.091190438 0.371070728 2.024739732 Up 8.36E-06 2.21E-05 SLC34A3 2 GO:0005903//brush border;GO:0031224//intrinsic to membrane;GO:0031982//vesicle;GO:0044459//plasma membrane part GO:0015081//sodium ion transmembrane transporter activity;GO:0015114//phosphate ion transmembrane transporter activity;GO:0015291//secondary active transmembrane transporter activity GO:0006817//phosphate ion transport;GO:0009991//response to extracellular stimulus;GO:0010038//response to metal ion;GO:0035725//sodium ion transmembrane transport;GO:0072502 gi|313104149|sp|Q8N130.2|NPT2C_HUMAN/0/RecName: Full=Sodium-dependent phosphate transport protein 2C; Short=Sodium-phosphate transport protein 2C; AltName: Full=Na(+)-dependent phosphate cotransporter 2C; AltName: Full=Sodium/inorganic phosphate cotransporter IIC; AltName: Full=Sodium/phosphate cotransporter 2C; Short=Na(+)/Pi cotransporter 2C; Short=NaPi-2c; AltName: Full=Solute carrier family 34 member 3 340152 4907 10 61 0.045013961 0.18283708 2.022114263 Up 2.63E-06 7.27E-06 ZC3H12D 2 GO:0043231//intracellular membrane-bounded organelle GO:0004518//nuclease activity;GO:0046914//transition metal ion binding - gi|282394049|ref|NP_997243.2|/0/probable ribonuclease ZC3H12D [Homo sapiens] 340351 3542 49 298 0.305570068 1.237423067 2.017763697 Up 7.07E-26 5.07E-25 AGBL3 3 GO:0044444//cytoplasmic part "GO:0046914//transition metal ion binding;GO:0070011//peptidase activity, acting on L-amino acid peptides" GO:0019538//protein metabolic process gi|222352158|ref|NP_848658.3|/0/cytosolic carboxypeptidase 3 [Homo sapiens] 203562 732 51 310 1.538942461 6.228753053 2.017004084 Up 7.56E-27 5.58E-26 TMEM31 2 GO:0016020//membrane - - gi|20809912|gb|AAH29575.1|/4.70968e-53/Transmembrane protein 31 [Homo sapiens] 25787 2434 39 235 0.353921805 1.42003088 2.004419748 Up 1.51E-20 8.95E-20 DGCR9 1 - - - gi|150385310|sp|Q3SYA9.2|P12L1_HUMAN/2.76132e-110/RecName: Full=Putative POM121-like protein 1 151516 2216 30 180 0.299030017 1.194684556 1.998267521 Up 5.28E-16 2.61E-15 ASPRV1 2 GO:0031224//intrinsic to membrane GO:0004175//endopeptidase activity GO:0006508//proteolysis;GO:0008544//epidermis development gi|189409122|ref|NP_690005.2|/2.35044e-177/retroviral-like aspartic protease 1 precursor [Homo sapiens] 2797 423 6 36 0.313309938 1.251735686 1.998267521 Up 0.000404242 0.000894336 GNRH2 1 GO:0000267//cell fraction GO:0005102//receptor binding GO:0023052//signaling;GO:0032501//multicellular organismal process gi|30581150|ref|NP_847901.1|/7.60735e-50/progonadoliberin-2 isoform c preproprotein [Homo sapiens]//gi|30581152|ref|NP_847902.1|/2.22058e-49/progonadoliberin-2 isoform b preproprotein [Homo sapiens]//gi|4504057|ref|NP_001492.1|/8.77275e-54/progonadoliberin-2 isoform a preproprotein [Homo sapiens] 23349 5950 12 72 0.044547934 0.177977881 1.998267521 Up 3.79E-07 1.12E-06 KIAA1045 1 - GO:0046914//transition metal ion binding - gi|5689427|dbj|BAA82997.1|/0/KIAA1045 protein [Homo sapiens] 158381 2867 11 66 0.08474777 0.338584243 1.998267521 Up 1.20E-06 3.41E-06 ATP8B5P 1 GO:0016020//membrane;GO:0030141//secretory granule "GO:0000166//nucleotide binding;GO:0005548//phospholipid transporter activity;GO:0016820//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;GO:0043492//ATPase activity, coupled to movement of substances" GO:0006869//lipid transport;GO:0006996//organelle organization;GO:0009205 gi|397519566|ref|XP_003829929.1|/0/PREDICTED: LOW QUALITY PROTEIN: probable phospholipid-transporting ATPase FetA-like [Pan paniscus]//gi|397519566|ref|XP_003829929.1|/8.27887e-136/PREDICTED: LOW QUALITY PROTEIN: probable phospholipid-transporting ATPase FetA-like [Pan paniscus] 10110 2146 6 36 0.061756805 0.246730753 1.998267521 Up 0.000404242 0.000894232 SGK2 2 - GO:0004672//protein kinase activity;GO:0016247//channel regulator activity;GO:0032559 GO:0006464//cellular protein modification process;GO:0006950//response to stress;GO:0035556//intracellular signal transduction gi|20127541|ref|NP_057360.2|/0/serine/threonine-protein kinase Sgk2 isoform beta [Homo sapiens] 3081 2012 6 36 0.065869833 0.263163119 1.998267521 Up 0.000404242 0.00089444 HGD 3 GO:0044444//cytoplasmic part "GO:0016702//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0043169//cation binding" GO:0006558//L-phenylalanine metabolic process;GO:0006570//tyrosine metabolic process "gi|115527117|ref|NP_000178.2|/0/homogentisate 1,2-dioxygenase [Homo sapiens]" 5458 3141 6 36 0.042193602 0.168571855 1.998267521 Up 0.000404242 0.000894128 POU4F2 2 GO:0005634//nucleus GO:0001071//nucleic acid binding transcription factor activity;GO:0003677//DNA binding GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0007411//axon guidance;GO:0045595//regulation of cell differentiation;GO:0048675//axon extension;GO:0050905//neuromuscular process;GO:0050954//sensory perception of mechanical stimulus "gi|110347455|ref|NP_004566.2|/6.64628e-160/POU domain, class 4, transcription factor 2 [Homo sapiens]" 619189 2494 29 174 0.256841286 1.026132161 1.998267521 Up 1.63E-15 7.84E-15 SERINC4 1 GO:0031224//intrinsic to membrane - GO:0006644//phospholipid metabolic process gi|384475530|ref|NP_001244960.1|/0/serine incorporator 4 isoform 1 [Homo sapiens]//gi|384475532|ref|NP_001244961.1|/2.95513e-146/serine incorporator 4 isoform 3 [Homo sapiens] 2620 2240 28 167 0.276104383 1.096526049 1.989654391 Up 7.18E-15 3.36E-14 GAS2 1 GO:0015629//actin cytoskeleton;GO:0044444//cytoplasmic part - GO:0006915//apoptotic process;GO:0022402//cell cycle process;GO:0065008 gi|4885253|ref|NP_005247.1|/2.11695e-161/growth arrest-specific protein 2 [Homo sapiens]//gi|4885253|ref|NP_005247.1|/2.31406e-161/growth arrest-specific protein 2 [Homo sapiens]//gi|4885253|ref|NP_005247.1|/2.3929e-161/growth arrest-specific protein 2 [Homo sapiens] 284427 1571 17 101 0.239020981 0.945574363 1.984053662 Up 1.80E-09 6.30E-09 SLC25A41 3 GO:0019866//organelle inner membrane;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle - GO:0006810//transport gi|149274607|ref|NP_775908.2|/0/solute carrier family 25 member 41 [Homo sapiens] 618 200 418 2476 46.16465279 182.0837315 1.979741488 Up 2.22E-198 1.22E-196 BCYRN1 1 - - - gi|119581507|gb|EAW61103.1|/1.74365e-06/hCG2003764 [Homo sapiens] 761 1753 9 53 0.113402827 0.444676782 1.971300474 Up 1.74E-05 4.44E-05 CA3 3 GO:0044424//intracellular part GO:0016836//hydro-lyase activity;GO:0046914//transition metal ion binding GO:0006950//response to stress;GO:0044237//cellular metabolic process gi|4885099|ref|NP_005172.1|/1.55167e-157/carbonic anhydrase 3 [Homo sapiens] 80115 2153 26 153 0.266742739 1.045196391 1.970253145 Up 1.40E-13 6.13E-13 BAIAP2L2 4 - "GO:0019904//protein domain specific binding;GO:0030674//protein binding, bridging" GO:0023052//signaling;GO:0030035//microspike assembly gi|113205091|ref|NP_079321.3|/0/brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 [Homo sapiens] 100268168 1594 8 47 0.110857469 0.43367066 1.967893872 Up 5.56E-05 0.000136188 LOC100268168 1 GO:0016021//integral to membrane GO:0004936//alpha-adrenergic receptor activity "GO:0001508//regulation of action potential;GO:0007166//cell surface receptor signaling pathway;GO:0007204//elevation of cytosolic calcium ion concentration;GO:0007266//Rho protein signal transduction;GO:0008283//cell proliferation;GO:0009719;GO:0010863//positive regulation of phospholipase C activity;GO:0012501//programmed cell death;GO:0019229//regulation of vasoconstriction;GO:0032228//regulation of synaptic transmission, GABAergic;GO:0032502//developmental process;GO:0042221//response to chemical stimulus;GO:0043410//positive regulation of MAPK cascade;GO:0045989//positive regulation of striated muscle contraction" gi|119577496|gb|EAW57092.1|/8.39182e-30/hCG1995581 [Homo sapiens]//gi|34531922|dbj|BAC86261.1|/2.33947e-17/unnamed protein product [Homo sapiens] 84660 3228 30 176 0.205282069 0.80191741 1.965846043 Up 2.21E-15 1.06E-14 CCDC62 4 GO:0043231//intracellular membrane-bounded organelle - - gi|30060228|gb|AAP13075.1|/0/aaa-protein [Homo sapiens] //gi|75677376|ref|NP_958843.2|/0/coiled-coil domain-containing protein 62 [Homo sapiens] 6023 277 32 187 2.551722815 9.929156084 1.96019948 Up 3.33E-16 1.66E-15 RMRP 3 - - - - 83591 4840 241 1405 1.099853822 4.269543698 1.956770099 Up 1.07E-111 3.20E-110 THAP2 3 GO:0031981//nuclear lumen GO:0003676//nucleic acid binding;GO:0043169//cation binding - gi|13899259|ref|NP_113623.1|/3.83986e-117/THAP domain-containing protein 2 [Homo sapiens] 441317 1844 17 99 0.203634469 0.78963207 1.955198799 Up 3.70E-09 1.26E-08 FAM90A7P 1 - GO:0046914//transition metal ion binding - gi|158513830|sp|A6NKC0.1|F90A7_HUMAN/0/RecName: Full=Putative protein FAM90A7P 79168 3930 11 64 0.0618249 0.239517872 1.953873402 Up 2.47E-06 6.84E-06 LILRA6 2 GO:0016021//integral to membrane GO:0004872//receptor activity GO:0006950//response to stress;GO:0007165//signal transduction gi|110611910|ref|NP_077294.2|/0/leukocyte immunoglobulin-like receptor subfamily A member 6 precursor [Homo sapiens] 326332 2177 10 58 0.101462336 0.391850193 1.949357921 Up 7.82E-06 2.07E-05 FLJ31813 1 GO:0005768//endosome;GO:0016020//membrane;GO:0043234//protein complex GO:0005488//binding GO:0016197//endosomal transport gi|154090959|ref|NP_060702.1|/1.25263e-48/WASH complex subunit FAM21B [Homo sapiens] 100289495 3908 44 254 0.248691767 0.955937859 1.942558089 Up 2.80E-21 1.71E-20 LOC100289495 1 GO:0043229//intracellular organelle - - gi|22209001|ref|NP_663748.1|/0/tigger transposable element-derived protein 1 [Homo sapiens] 11155 5436 14 80 0.056886849 0.216451719 1.927878193 Up 1.61E-07 4.92E-07 LDB3 1 GO:0030016//myofibril;GO:0031674//I band;GO:0042995//cell projection GO:0019901//protein kinase binding;GO:0046872//metal ion binding;GO:0046914//transition metal ion binding - gi|122056614|ref|NP_001073583.1|/0/LIM domain-binding protein 3 isoform 2 [Homo sapiens]//gi|122056617|ref|NP_001073584.1|/1.0264e-166/LIM domain-binding protein 3 isoform 3 [Homo sapiens]//gi|122056619|ref|NP_001073585.1|/3.79952e-158/LIM domain-binding protein 3 isoform 4 [Homo sapiens]//gi|284413714|ref|NP_001165081.1|/0/LIM domain-binding protein 3 isoform 5 [Homo sapiens] //gi|284413714|ref|NP_001165081.1|/2.98022e-171/LIM domain-binding protein 3 isoform 5 [Homo sapiens] //gi|284413716|ref|NP_001165082.1|/0/LIM domain-binding protein 3 isoform 6 [Homo sapiens] 5169 3180 7 40 0.048622155 0.18500496 1.927878193 Up 0.00025783 0.000583148 ENPP3 3 GO:0016021//integral to membrane;GO:0044444//cytoplasmic part GO:0001871;GO:0004527//exonuclease activity;GO:0004888//transmembrane signaling receptor activity;GO:0016462//pyrophosphatase activity;GO:0043169//cation binding GO:0002376//immune system process;GO:0006793//phosphorus metabolic process;GO:0009141//nucleoside triphosphate metabolic process;GO:0015698//inorganic anion transport gi|111160296|ref|NP_005012.2|/0/ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [Homo sapiens] 29802 602 10 57 0.366916123 1.392607933 1.92426694 Up 1.12E-05 2.92E-05 VPREB3 2 GO:0043231//intracellular membrane-bounded organelle - - gi|7019567|ref|NP_037510.1|/2.21439e-67/pre-B lymphocyte protein 3 precursor [Homo sapiens] 80217 5365 76 430 0.312901146 1.178824707 1.913570357 Up 2.36E-34 2.13E-33 WDR96 5 - - - gi|94681049|ref|NP_079421.5|/0/WD repeat-containing protein 96 [Homo sapiens] 339488 2189 16 90 0.161449799 0.604710136 1.905158117 Up 3.35E-08 1.07E-07 TFAP2E 3 GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0003676//nucleic acid binding;GO:0042802//identical protein binding;GO:0046983//protein dimerization activity GO:0006357//regulation of transcription from RNA polymerase II promoter gi|194353976|ref|NP_848643.2|/2.32588e-161/transcription factor AP-2-epsilon [Homo sapiens] 92745 2006 8 45 0.088089135 0.329937808 1.905158117 Up 0.000114435 0.000270109 SLC38A5 2 GO:0031224//intrinsic to membrane GO:0015175//neutral amino acid transmembrane transporter activity GO:0006807//nitrogen compound metabolic process;GO:0015804//neutral amino acid transport gi|193788624|ref|NP_277053.2|/0/sodium-coupled neutral amino acid transporter 5 [Homo sapiens] 1734 6379 13 73 0.045014667 0.1683142 1.902689861 Up 7.23E-07 2.09E-06 DIO2 4 GO:0031224//intrinsic to membrane GO:0016491//oxidoreductase activity;GO:0019899//enzyme binding GO:0006451//translational readthrough;GO:0019336;GO:0042403//thyroid hormone metabolic process gi|4009517|gb|AAC95470.1|/3.49576e-155/type 2 iodothyronine deiodinase [Homo sapiens]//gi|4009517|gb|AAC95470.1|/3.62165e-155/type 2 iodothyronine deiodinase [Homo sapiens]//gi|55749998|ref|NP_001007024.1|/2.18062e-173/type II iodothyronine deiodinase isoform b [Homo sapiens]//gi|7549803|ref|NP_054644.1|/6.49403e-109/type II iodothyronine deiodinase isoform a [Homo sapiens]//gi|7549803|ref|NP_054644.1|/6.61636e-109/type II iodothyronine deiodinase isoform a [Homo sapiens] 15 1935 12 67 0.136982019 0.509265591 1.89443171 Up 2.28E-06 6.32E-06 AANAT 1 GO:0044444//cytoplasmic part GO:0008080//N-acetyltransferase activity GO:0009058//biosynthetic process;GO:0009648//photoperiodism;GO:0010038//response to metal ion;GO:0030186//melatonin metabolic process;GO:0034694//response to prostaglandin stimulus;GO:0043434//response to peptide hormone stimulus;GO:0048511//rhythmic process;GO:0051384//response to glucocorticoid stimulus gi|262231744|ref|NP_001160051.1|/1.66666e-136/serotonin N-acetyltransferase isoform 1 [Homo sapiens]//gi|262231744|ref|NP_001160051.1|/3.91646e-149/serotonin N-acetyltransferase isoform 1 [Homo sapiens] 85462 6480 257 1430 0.876034893 3.245723589 1.889479903 Up 1.21E-108 3.52E-107 FHDC1 2 - GO:0008092//cytoskeletal protein binding GO:0007010//cytoskeleton organization gi|145309324|ref|NP_203751.2|/0/FH2 domain-containing protein 1 [Homo sapiens] 7101 3271 9 50 0.06077504 0.224822597 1.887236209 Up 5.10E-05 0.000125224 NR2E1 3 GO:0031981//nuclear lumen GO:0000982//RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity;GO:0003677//DNA binding;GO:0004879//ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity;GO:0046914//transition metal ion binding GO:0001654//eye development;GO:0002042//cell migration involved in sprouting angiogenesis;GO:0002209//behavioral defense response;GO:0006915//apoptotic process;GO:0008284//positive regulation of cell proliferation;GO:0008285//negative regulation of cell proliferation;GO:0009755//hormone-mediated signaling pathway;GO:0010769//regulation of cell morphogenesis involved in differentiation;GO:0019827//stem cell maintenance;GO:0021766//hippocampus development;GO:0021953//central nervous system neuron differentiation;GO:0021988//olfactory lobe development;GO:0043062//extracellular structure organization;GO:0045664//regulation of neuron differentiation;GO:0045686//negative regulation of glial cell differentiation;GO:0045765//regulation of angiogenesis;GO:0048167//regulation of synaptic plasticity;GO:0050953//sensory perception of light stimulus;GO:0051705;GO:0051726//regulation of cell cycle gi|4507537|ref|NP_003260.1|/0/nuclear receptor subfamily 2 group E member 1 [Homo sapiens] 642366 6699 89 494 0.293456218 1.084594684 1.885938821 Up 1.59E-38 1.60E-37 LOC642366 1 - - - gi|297675237|ref|XP_002815594.1|/1.79337e-36/PREDICTED: uncharacterized protein LOC100436501 [Pongo abelii] 84329 1736 23 127 0.292645198 1.075980747 1.878427751 Up 6.93E-11 2.64E-10 HVCN1 1 GO:0031224//intrinsic to membrane GO:0015252//hydrogen ion channel activity GO:0006810//transport;GO:0006818//hydrogen transport;GO:0009628//response to abiotic stimulus;GO:0010038//response to metal ion gi|91992153|ref|NP_001035196.1|/1.65857e-95/voltage-gated hydrogen channel 1 isoform 1 [Homo sapiens]//gi|91992153|ref|NP_001035196.1|/1.66993e-95/voltage-gated hydrogen channel 1 isoform 1 [Homo sapiens]//gi|91992153|ref|NP_001035196.1|/7.04641e-91/voltage-gated hydrogen channel 1 isoform 1 [Homo sapiens] 414778 746 8 44 0.236872393 0.867489745 1.872736639 Up 0.000163473 0.000379465 HCG17 1 - - - gi|119623682|gb|EAX03277.1|/9.63573e-33/hCG2040863 [Homo sapiens] 3263 1635 17 93 0.229664808 0.836595823 1.86500099 Up 3.07E-08 9.89E-08 HPX 2 GO:0044421//extracellular region part GO:0005506//iron ion binding;GO:0051184 GO:0001961//positive regulation of cytokine-mediated signaling pathway;GO:0002377//immunoglobulin production;GO:0002455//humoral immune response mediated by circulating immunoglobulin;GO:0006778//porphyrin-containing compound metabolic process;GO:0006875//cellular metal ion homeostasis;GO:0042508//tyrosine phosphorylation of Stat1 protein;GO:0051181//cofactor transport;GO:0051704;GO:0060255;GO:0060330//regulation of response to interferon-gamma gi|11321561|ref|NP_000604.1|/0/hemopexin precursor [Homo sapiens] 57096 3950 12 65 0.06710385 0.24202864 1.850710333 Up 4.60E-06 1.24E-05 RPGRIP1 3 GO:0042995//cell projection;GO:0043231//intracellular membrane-bounded organelle - GO:0001754//eye photoreceptor cell differentiation;GO:0050953//sensory perception of light stimulus gi|112734867|ref|NP_065099.3|/0/X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 [Homo sapiens] 89801 3448 221 1196 1.415755652 5.101694197 1.849404135 Up 1.19E-88 2.77E-87 PPP1R3F 1 GO:0016020//membrane;GO:0031224//intrinsic to membrane - - gi|194383480|dbj|BAG64711.1|/0/unnamed protein product [Homo sapiens]//gi|58761532|ref|NP_149992.3|/0/protein phosphatase 1 regulatory subunit 3F isoform 1 [Homo sapiens] 3034 3927 39 211 0.219364827 0.790263738 1.84900199 Up 6.98E-17 3.58E-16 HAL 1 GO:0000267//cell fraction;GO:0044444//cytoplasmic part GO:0016841//ammonia-lyase activity GO:0006547//histidine metabolic process gi|385251411|ref|NP_001245263.1|/0/histidine ammonia-lyase isoform 3 [Homo sapiens]//gi|4504333|ref|NP_002099.1|/0/histidine ammonia-lyase isoform 1 [Homo sapiens] 716 2850 32 173 0.248009551 0.892794988 1.847933248 Up 4.46E-14 2.01E-13 C1S 3 - GO:0004175//endopeptidase activity;GO:0046872//metal ion binding GO:0002455//humoral immune response mediated by circulating immunoglobulin;GO:0006952//defense response;GO:0010033//response to organic substance;GO:0019538//protein metabolic process;GO:0030154//cell differentiation gi|4502495|ref|NP_001725.1|/0/complement C1s subcomponent precursor [Homo sapiens] 83733 2087 25 135 0.264594521 0.951397092 1.846264428 Up 2.91E-11 1.14E-10 SLC25A18 1 GO:0019866//organelle inner membrane;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle GO:0015291//secondary active transmembrane transporter activity GO:0006810//transport gi|13899342|ref|NP_113669.1|/3.36589e-178/mitochondrial glutamate carrier 2 [Homo sapiens] 403340 3126 61 328 0.431026676 1.543246747 1.840119687 Up 2.66E-25 1.87E-24 MGC70870 1 GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex;GO:0044459//plasma membrane part "GO:0000166//nucleotide binding;GO:0003712//transcription cofactor activity;GO:0016614//oxidoreductase activity, acting on CH-OH group of donors" "GO:0006355//regulation of transcription, DNA-dependent;GO:0008283//cell proliferation;GO:0019058//viral infectious cycle;GO:0045444//fat cell differentiation" gi|282721029|ref|NP_001164215.1|/9.69497e-157/C-terminal-binding protein 2 isoform 1 [Mus musculus] 8817 1999 8 43 0.088397601 0.316377917 1.839569775 Up 0.000232834 0.000530137 FGF18 2 GO:0031981//nuclear lumen;GO:0044421//extracellular region part GO:0005104//fibroblast growth factor receptor binding GO:0001503//ossification;GO:0002062//chondrocyte differentiation;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008283//cell proliferation;GO:0030323//respiratory tube development;GO:0043410//positive regulation of MAPK cascade;GO:0048646//anatomical structure formation involved in morphogenesis gi|4503695|ref|NP_003853.1|/2.7861e-89/fibroblast growth factor 18 precursor [Homo sapiens] 5475 2873 8 43 0.061506023 0.220132076 1.839569775 Up 0.000232834 0.000530074 PPEF1 1 - GO:0004721//phosphoprotein phosphatase activity;GO:0046914//transition metal ion binding GO:0006464//cellular protein modification process;GO:0051606//detection of stimulus gi|23312374|ref|NP_689410.1|/0/serine/threonine-protein phosphatase with EF-hands 1 isoform 1b [Homo sapiens]//gi|23312378|ref|NP_689412.1|/0/serine/threonine-protein phosphatase with EF-hands 1 isoform 3 [Homo sapiens]//gi|23312380|ref|NP_006231.2|/0/serine/threonine-protein phosphatase with EF-hands 1 isoform 1 [Homo sapiens] 200350 2067 20 107 0.21372376 0.761366565 1.832843912 Up 4.11E-09 1.40E-08 FOXD4L1 4 GO:0031981//nuclear lumen;GO:0043234//protein complex GO:0000981//sequence-specific DNA binding RNA polymerase II transcription factor activity;GO:0005515//protein binding;GO:0043565//sequence-specific DNA binding;GO:0043566//structure-specific DNA binding GO:0000122//negative regulation of transcription from RNA polymerase II promoter;GO:0001667//ameboidal cell migration;GO:0001822//kidney development;GO:0021782//glial cell development;GO:0030509//BMP signaling pathway;GO:0048675//axon extension;GO:0050931//pigment cell differentiation;GO:0060600 gi|18959276|ref|NP_036316.1|/1.94843e-178/forkhead box protein D4-like 1 [Homo sapiens] 55515 2857 12 64 0.092775711 0.329473306 1.82834252 Up 6.51E-06 1.74E-05 ASIC4 2 GO:0016021//integral to membrane GO:0005261//cation channel activity;GO:0046873//metal ion transmembrane transporter activity GO:0035725//sodium ion transmembrane transport gi|256773230|ref|NP_878267.2|/0/acid-sensing ion channel 4 [Homo sapiens] 203102 2742 10 53 0.080555619 0.284288256 1.81929738 Up 4.60E-05 0.000113319 ADAM32 5 GO:0031224//intrinsic to membrane GO:0004175//endopeptidase activity;GO:0046914//transition metal ion binding GO:0019538//protein metabolic process gi|148664238|ref|NP_659441.3|/0/disintegrin and metalloproteinase domain-containing protein 32 precursor [Homo sapiens] 91450 1016 10 53 0.217405026 0.767242518 1.81929738 Up 4.60E-05 0.000113333 LOC91450 1 - - - - 7462 2199 49 259 0.492191533 1.732307697 1.815403464 Up 6.02E-20 3.47E-19 LAT2 2 GO:0031224//intrinsic to membrane GO:0019904//protein domain specific binding GO:0002279;GO:0019932//second-messenger-mediated signaling;GO:0046649//lymphocyte activation;GO:0050851//antigen receptor-mediated signaling pathway gi|14702182|ref|NP_054865.2|/3.27925e-122/linker for activation of T-cells family member 2 precursor [Homo sapiens]//gi|14702182|ref|NP_054865.2|/3.50712e-122/linker for activation of T-cells family member 2 precursor [Homo sapiens]//gi|14702182|ref|NP_054865.2|/3.64864e-122/linker for activation of T-cells family member 2 precursor [Homo sapiens] 90246 2761 142 748 1.136018033 3.984608816 1.810452361 Up 1.50E-54 2.10E-53 LOC90246 1 - - - gi|119599717|gb|EAW79311.1|/3.07831e-12/hCG2022765 [Homo sapiens] 10343 7660 177 930 0.510396614 1.785684296 1.806786376 Up 3.09E-67 5.34E-66 PKDREJ 1 GO:0031224//intrinsic to membrane GO:0015075//ion transmembrane transporter activity;GO:0046872//metal ion binding GO:0006810//transport;GO:0007186//G-protein coupled receptor signaling pathway;GO:0007338//single fertilization gi|5174633|ref|NP_006062.1|/0/polycystic kidney disease and receptor for egg jelly-related protein precursor [Homo sapiens] 7399 18883 8 42 0.009357984 0.032713635 1.805622443 Up 0.000330602 0.000739315 USH2A 2 GO:0002141//stereocilia ankle link;GO:0005578//proteinaceous extracellular matrix;GO:0031224//intrinsic to membrane;GO:0031528//microvillus membrane;GO:0043232 GO:0008092//cytoskeletal protein binding GO:0042490//mechanoreceptor differentiation;GO:0043954//cellular component maintenance;GO:0045596//negative regulation of cell differentiation;GO:0050954//sensory perception of mechanical stimulus gi|219842259|ref|NP_009054.5|/0/usherin isoform A [Homo sapiens]//gi|219842266|ref|NP_996816.2|/0/usherin isoform B [Homo sapiens] 400709 1714 8 42 0.103096152 0.360403478 1.805622443 Up 0.000330602 0.000739401 SIGLEC16 1 GO:0031224//intrinsic to membrane GO:0030246//carbohydrate binding GO:0009987//cellular process "gi|119572970|gb|EAW52585.1|/5.01664e-81/sialic acid binding Ig-like lectin 11, isoform CRA_b [Homo sapiens]" 8483 4484 8 42 0.039408297 0.137763506 1.805622443 Up 0.000330602 0.000739228 CILP 3 GO:0031012//extracellular matrix GO:0016462//pyrophosphatase activity;GO:0016791//phosphatase activity GO:0009968//negative regulation of signal transduction gi|192449445|ref|NP_003604.3|/0/cartilage intermediate layer protein 1 preproprotein [Homo sapiens] 112476 3195 122 639 0.843436236 2.941578861 1.802239804 Up 1.46E-46 1.74E-45 PRRT2 2 GO:0031224//intrinsic to membrane - GO:0050896//response to stimulus gi|156523246|ref|NP_660282.2|/4.40922e-146/proline-rich transmembrane protein 2 isoform 1 [Homo sapiens]//gi|156523246|ref|NP_660282.2|/4.90175e-143/proline-rich transmembrane protein 2 isoform 1 [Homo sapiens]//gi|374253785|ref|NP_001243372.1|/1.4233e-133/proline-rich transmembrane protein 2 isoform 3 [Homo sapiens] 59285 1886 9 47 0.105405703 0.366527589 1.797968871 Up 0.000146273 0.000340868 CACNG6 1 GO:0016021//integral to membrane;GO:0034704//calcium channel complex GO:0005262//calcium channel activity GO:0032412//regulation of ion transmembrane transporter activity;GO:0034765//regulation of ion transmembrane transport;GO:0070838//divalent metal ion transport gi|22027554|ref|NP_665813.1|/6.80417e-90/voltage-dependent calcium channel gamma-6 subunit isoform a [Homo sapiens]//gi|22027557|ref|NP_665814.1|/3.64444e-82/voltage-dependent calcium channel gamma-6 subunit isoform b [Homo sapiens]//gi|22027560|ref|NP_114103.2|/2.24511e-57/voltage-dependent calcium channel gamma-6 subunit isoform c [Homo sapiens] 201294 4406 28 146 0.140370816 0.487370079 1.795774657 Up 1.10E-11 4.37E-11 UNC13D 2 GO:0000323//lytic vacuole;GO:0005768//endosome;GO:0030133//transport vesicle GO:0005488//binding GO:0002323//natural killer cell activation involved in immune response;GO:0002460//adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;GO:0002886;GO:0006897//endocytosis;GO:0017157//regulation of exocytosis gi|46195765|ref|NP_954712.1|/0/protein unc-13 homolog D [Homo sapiens] 201243 1670 16 83 0.211624916 0.730991154 1.788344452 Up 3.80E-07 1.13E-06 C17orf74 4 GO:0031224//intrinsic to membrane - - gi|154240732|ref|NP_783861.3|/0/uncharacterized protein C17orf74 [Homo sapiens] 100506714 1338 77 399 1.271153212 4.385986419 1.786763416 Up 2.46E-29 1.95E-28 LOC100506714 1 - - - gi|119593775|gb|EAW73369.1|/8.09904e-20/hCG1805852 [Homo sapiens] 23632 1757 19 98 0.238860934 0.820360639 1.780087351 Up 3.54E-08 1.13E-07 CA14 1 GO:0031224//intrinsic to membrane GO:0016836//hydro-lyase activity;GO:0043169//cation binding - gi|6912284|ref|NP_036245.1|/0/carbonic anhydrase 14 precursor [Homo sapiens] 55080 1834 13 67 0.156569552 0.537311297 1.778954493 Up 5.83E-06 1.56E-05 TAPBPL 4 GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0042598;GO:0043231//intracellular membrane-bounded organelle - GO:0002474//antigen processing and presentation of peptide antigen via MHC class I gi|157739930|ref|NP_060479.3|/0/tapasin-related protein precursor [Homo sapiens] 79819 3871 99 507 0.56490486 1.926350404 1.769790337 Up 2.09E-36 2.00E-35 WDR78 4 - - - gi|282165776|ref|NP_996897.2|/0/WD repeat-containing protein 78 isoform 2 [Homo sapiens]//gi|282165778|ref|NP_079039.4|/0/WD repeat-containing protein 78 isoform 1 [Homo sapiens] 131450 2272 17 87 0.16527375 0.563198418 1.768785675 Up 2.42E-07 7.27E-07 CD200R1 2 GO:0031224//intrinsic to membrane GO:0004871//signal transducer activity GO:0002682//regulation of immune system process;GO:0051704 gi|25777655|ref|NP_620385.1|/5.40603e-92/cell surface glycoprotein CD200 receptor 1 isoform b precursor [Homo sapiens]//gi|25777657|ref|NP_620386.1|/1.0499e-78/cell surface glycoprotein CD200 receptor 1 isoform c precursor [Homo sapiens]//gi|25777659|ref|NP_740750.1|/2.41762e-166/cell surface glycoprotein CD200 receptor 1 isoform d precursor [Homo sapiens]//gi|33469474|gb|AAQ19772.1|/1.16111e-179/CD200 cell surface glycoprotein receptor isoform 1 [Homo sapiens] 1302 6425 202 1033 0.694450868 2.364708921 1.767718076 Up 2.26E-72 4.22E-71 COL11A2 1 GO:0005583//fibrillar collagen GO:0005201//extracellular matrix structural constituent;GO:0005515//protein binding GO:0009888//tissue development;GO:0030198//extracellular matrix organization;GO:0032501//multicellular organismal process;GO:0048731;GO:0048856//anatomical structure development;GO:0050954//sensory perception of mechanical stimulus gi|254939712|ref|NP_001157243.1|/1.97944e-142/collagen alpha-2(XI) chain isoform 4 precursor [Homo sapiens]//gi|374095517|sp|P13942.5|COBA2_HUMAN/0/RecName: Full=Collagen alpha-2(XI) chain; Flags: Precursor//gi|397474332|ref|XP_003808636.1|/0/PREDICTED: collagen alpha-2(XI) chain-like isoform 2 [Pan paniscus]//gi|397474334|ref|XP_003808637.1|/0/PREDICTED: collagen alpha-2(XI) chain-like isoform 3 [Pan paniscus] 8608 1738 9 46 0.114381562 0.389276834 1.766941975 Up 0.000206646 0.000473338 RDH16 3 GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0042598;GO:0043231//intracellular membrane-bounded organelle "GO:0016616//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" GO:0044238//primary metabolic process gi|150247226|ref|NP_003699.3|/0/retinol dehydrogenase 16 [Homo sapiens] 51226 923 9 46 0.215379367 0.733004483 1.766941975 Up 0.000206646 0.000473395 COPZ2 2 GO:0005798//Golgi-associated vesicle;GO:0030120//vesicle coat - GO:0015031//protein transport gi|7705983|ref|NP_057513.1|/1.37246e-96/coatomer subunit zeta-2 [Homo sapiens] 345895 2858 98 500 0.757403205 2.573109571 1.764379461 Up 8.79E-36 8.26E-35 RSPH4A 1 GO:0005929//cilium;GO:0005930//axoneme;GO:0043232;GO:0043234//protein complex - GO:0006928//cellular component movement;GO:0010927 gi|239582735|ref|NP_001155136.1|/0/radial spoke head protein 4 homolog A isoform 2 [Homo sapiens]//gi|58219006|ref|NP_001010892.1|/0/radial spoke head protein 4 homolog A isoform 1 [Homo sapiens] 1193 2702 10 51 0.081748152 0.277610144 1.763802267 Up 9.17E-05 0.000219001 CLIC2 4 GO:0034702//ion channel complex;GO:0043231//intracellular membrane-bounded organelle GO:0005254//chloride channel activity;GO:0015036//disulfide oxidoreductase activity GO:0015698//inorganic anion transport;GO:0019725//cellular homeostasis;GO:0023052//signaling "gi|169404567|pdb|2PER|A/4.03269e-142/Chain A, Crystal Structure Of Human Chloride Intracellular Channel Protein 2" 221442 4585 171 870 0.823796719 2.790810915 1.760324096 Up 7.00E-61 1.09E-59 ADCY10P1 2 - - - gi|297290798|ref|XP_001114224.2|/1.04883e-165/PREDICTED: adenylate cyclase type 10-like [Macaca mulatta] 3936 3808 48 244 0.278424588 0.942417597 1.759079857 Up 3.78E-18 2.04E-17 LCP1 4 GO:0001726//ruffle;GO:0015629//actin cytoskeleton;GO:0044444//cytoplasmic part;GO:0044459//plasma membrane part GO:0003779//actin binding;GO:0046872//metal ion binding GO:0002285;GO:0006886//intracellular protein transport;GO:0006950//response to stress;GO:0007015//actin filament organization;GO:0009887//organ morphogenesis gi|167614506|ref|NP_002289.2|/0/plastin-2 [Homo sapiens] 399474 2584 25 127 0.213703083 0.722872514 1.758133517 Up 4.43E-10 1.60E-09 TMEM200B 1 - - - gi|51242137|ref|NP_001003682.1|/6.80397e-104/transmembrane protein 200B [Homo sapiens]//gi|51242137|ref|NP_001003682.1|/7.04318e-104/transmembrane protein 200B [Homo sapiens] 643596 1514 13 66 0.189662192 0.64116316 1.757259422 Up 8.20E-06 2.16E-05 RNF224 1 - GO:0046872//metal ion binding - gi|298160964|ref|NP_001177157.1|/5.17168e-74/RING finger protein 224 [Homo sapiens] 3750 4720 154 781 0.720679236 2.433657935 1.755697218 Up 1.24E-54 1.73E-53 KCND1 4 GO:0005887//integral to plasma membrane GO:0005267//potassium channel activity;GO:0043169//cation binding GO:0030001//metal ion transport;GO:0034220//ion transmembrane transport gi|27436981|ref|NP_004970.3|/0/potassium voltage-gated channel subfamily D member 1 precursor [Homo sapiens] 10256 2564 59 299 0.508273279 1.715156161 1.754663645 Up 7.55E-22 4.68E-21 CNKSR1 2 GO:0030054//cell junction;GO:0044444//cytoplasmic part GO:0005515//protein binding GO:0007167//enzyme linked receptor protein signaling pathway;GO:0007265//Ras protein signal transduction gi|188497618|ref|NP_006305.2|/0/connector enhancer of kinase suppressor of ras 1 [Homo sapiens] 169436 2779 15 76 0.119224635 0.402231007 1.754341938 Up 1.66E-06 4.67E-06 C9orf96 3 - GO:0016301//kinase activity;GO:0032559 GO:0006464//cellular protein modification process gi|76563908|ref|NP_714921.3|/0/protein kinase-like protein SgK071 [Homo sapiens] 339666 1558 34 172 0.482030758 1.623721323 1.752106934 Up 3.91E-13 1.68E-12 LOC339666 1 - - - "gi|119579992|gb|EAW59588.1|/3.92959e-08/hCG1812916, isoform CRA_a [Homo sapiens]" 751071 1382 138 696 2.205638484 7.407159506 1.747724059 Up 1.42E-48 1.76E-47 METTL12 1 GO:0043231//intracellular membrane-bounded organelle GO:0016741 GO:0006730//one-carbon metabolic process "gi|112734863|ref|NP_001036694.1|/5.89061e-130/methyltransferase-like protein 12, mitochondrial precursor [Homo sapiens]" 4242 2129 14 70 0.14524984 0.483585064 1.735233115 Up 5.17E-06 1.39E-05 MFNG 1 GO:0031228//intrinsic to Golgi membrane;GO:0044421//extracellular region part GO:0008375//acetylglucosaminyltransferase activity GO:0007275//multicellular organismal development "gi|21536461|ref|NP_002396.2|/4.66368e-175/beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform 1 [Homo sapiens]//gi|261824031|ref|NP_001159815.1|/2.19376e-166/beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform 2 [Homo sapiens] //gi|261824031|ref|NP_001159815.1|/4.47495e-160/beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform 2 [Homo sapiens] " 440435 7980 35 175 0.096878731 0.322541542 1.735233115 Up 3.48E-13 1.50E-12 GPR179 2 GO:0031224//intrinsic to membrane GO:0004888//transmembrane signaling receptor activity - gi|93352554|ref|NP_001004334.2|/0/probable G-protein coupled receptor 179 precursor [Homo sapiens] 646892 1892 11 55 0.128420643 0.427555067 1.735233115 Up 5.74E-05 0.000140519 SH2D7 1 - - - gi|157820785|ref|NP_001094874.1|/0/SH2 domain-containing protein 7 [Homo sapiens] 345275 2395 10 50 0.092226934 0.307054161 1.735233115 Up 0.000129012 0.00030253 HSD17B13 1 - GO:0003824//catalytic activity GO:0008152//metabolic process gi|210032110|ref|NP_835236.2|/5.04367e-157/17-beta-hydroxysteroid dehydrogenase 13 isoform A precursor [Homo sapiens]//gi|210032112|ref|NP_001129702.1|/2.30251e-135/17-beta-hydroxysteroid dehydrogenase 13 isoform B [Homo sapiens] 100302736 3627 27 134 0.164429409 0.543385122 1.724506709 Up 2.51E-10 9.21E-10 TMED7-TICAM2 2 GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle GO:0004872//receptor activity;GO:0005488//binding GO:0001816//cytokine production;GO:0002224//toll-like receptor signaling pathway;GO:0007166//cell surface receptor signaling pathway;GO:0007249//I-kappaB kinase/NF-kappaB cascade;GO:0051234//establishment of localization gi|256985100|ref|NP_001157940.1|/0/TRAM adaptor with GOLD domain isoform 1 precursor [Homo sapiens] 729956 6035 17 84 0.062220706 0.204716342 1.718159602 Up 6.63E-07 1.92E-06 SHISA7 1 GO:0031224//intrinsic to membrane - - gi|223633890|ref|NP_001138648.1|/0/protein shisa-7 precursor [Homo sapiens] 9961 2943 176 868 1.320947913 4.337904267 1.715424634 Up 1.09E-58 1.64E-57 MVP 3 GO:0005635//nuclear envelope;GO:0032991//macromolecular complex GO:0005488//binding GO:0042221//response to chemical stimulus;GO:0050658//RNA transport gi|19913410|ref|NP_059447.2|/0/major vault protein [Homo sapiens] 3383 3249 14 69 0.095179104 0.312356019 1.714474555 Up 7.23E-06 1.92E-05 ICAM1 2 GO:0009986//cell surface;GO:0016021//integral to membrane;GO:0044421//extracellular region part;GO:0044459//plasma membrane part GO:0004872//receptor activity;GO:0005102//receptor binding GO:0001101//response to acid;GO:0001666//response to hypoxia;GO:0001678//cellular glucose homeostasis;GO:0001909//leukocyte mediated cytotoxicity;GO:0002286//T cell activation involved in immune response;GO:0002456//T cell mediated immunity;GO:0002687//positive regulation of leukocyte migration;GO:0007568//aging;GO:0009314//response to radiation;GO:0009725//response to hormone stimulus;GO:0010038//response to metal ion;GO:0016337//cell-cell adhesion;GO:0019221//cytokine-mediated signaling pathway;GO:0019229//regulation of vasoconstriction;GO:0022406//membrane docking;GO:0022415;GO:0022602//ovulation cycle process;GO:0031328//positive regulation of cellular biosynthetic process;GO:0031667//response to nutrient levels;GO:0032496//response to lipopolysaccharide;GO:0034612//response to tumor necrosis factor;GO:0043271//negative regulation of ion transport;GO:0043279//response to alkaloid;GO:0051091//positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051702//interaction with symbiont;GO:0070555//response to interleukin-1 gi|167466198|ref|NP_000192.2|/0/intercellular adhesion molecule 1 precursor [Homo sapiens] 8111 2880 12 59 0.092034794 0.301307557 1.710985569 Up 3.59E-05 8.95E-05 GPR68 1 GO:0016021//integral to membrane GO:0004888//transmembrane signaling receptor activity GO:0006952//defense response;GO:0007166//cell surface receptor signaling pathway gi|47834444|gb|AAT38917.1|/0/ovarian cancer G protein-coupled receptor 1 [Homo sapiens] 643723 1642 12 59 0.161425218 0.528480977 1.710985569 Up 3.59E-05 8.95E-05 LOC643723 1 - - - - 8029 11933 44 216 0.081445356 0.26622854 1.708760904 Up 1.19E-15 5.77E-15 CUBN 3 GO:0005626//insoluble fraction;GO:0005764//lysosome;GO:0005903//brush border;GO:0009897//external side of plasma membrane;GO:0012505//endomembrane system;GO:0030139//endocytic vesicle;GO:0031090//organelle membrane;GO:0032991//macromolecular complex GO:0004871//signal transducer activity;GO:0019842//vitamin binding;GO:0042802//identical protein binding;GO:0046872//metal ion binding GO:0006775;GO:0006897//endocytosis;GO:0009058//biosynthetic process;GO:0016125//sterol metabolic process;GO:0017038//protein import;GO:0023052//signaling;GO:0031667//response to nutrient levels;GO:0043009//chordate embryonic development;GO:0044260;GO:0048871//multicellular organismal homeostasis;GO:0051180//vitamin transport;GO:0051260//protein homooligomerization gi|126091152|ref|NP_001072.2|/0/cubilin precursor [Homo sapiens] 284306 2788 64 314 0.507049656 1.656484509 1.707925769 Up 4.27E-22 2.67E-21 ZNF547 2 - GO:0005488//binding - gi|390479459|ref|XP_002762586.2|/0/PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100412703 [Callithrix jacchus] 1943 2143 61 299 0.628739798 2.052104712 1.706569357 Up 4.34E-21 2.63E-20 EFNA2 3 GO:0031224//intrinsic to membrane;GO:0043025//neuronal cell body;GO:0045202//synapse GO:0005102//receptor binding GO:0006935//chemotaxis;GO:0007154//cell communication;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0021988//olfactory lobe development;GO:0042471//ear morphogenesis gi|27894381|ref|NP_001396.2|/1.8803e-115/ephrin-A2 precursor [Homo sapiens] 154442 1725 30 147 0.384145228 1.253368384 1.70608677 Up 4.65E-11 1.79E-10 BVES-AS1 1 - - - gi|55958949|emb|CAI13617.1|/3.99384e-49/novel protein [Homo sapiens] 8942 1774 9 44 0.112060403 0.364795575 1.702811638 Up 0.000408664 0.000903385 KYNU 1 GO:0000267//cell fraction;GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part GO:0016823;GO:0042802//identical protein binding;GO:0048037//cofactor binding GO:0006568//tryptophan metabolic process;GO:0019359//nicotinamide nucleotide biosynthetic process;GO:0033273//response to vitamin;GO:0034097//response to cytokine stimulus;GO:0043650 gi|4504937|ref|NP_003928.1|/0/kynureninase isoform a [Homo sapiens]//gi|74101437|ref|NP_001028170.1|/1.9934e-172/kynureninase isoform b [Homo sapiens] 554236 2827 12 58 0.093760243 0.301753757 1.686323515 Up 5.02E-05 0.000123362 DPY19L2P1 2 GO:0031224//intrinsic to membrane - - gi|37182703|gb|AAQ89152.1|/0/RKQG3127 [Homo sapiens] 25876 1597 47 227 0.65006417 2.090602384 1.685264656 Up 4.27E-16 2.12E-15 SPEF1 4 GO:0019861//flagellum - - gi|89363026|ref|NP_056232.2|/2.39171e-109/sperm flagellar protein 1 [Homo sapiens] 7007 6468 139 671 0.474687807 1.525818967 1.684532904 Up 1.19E-44 1.37E-43 TECTA 2 GO:0031012//extracellular matrix;GO:0031224//intrinsic to membrane GO:0005198//structural molecule activity GO:0031589//cell-substrate adhesion;GO:0050954//sensory perception of mechanical stimulus gi|134268640|ref|NP_005413.2|/0/alpha-tectorin precursor [Homo sapiens] 4588 8003 17 82 0.04692015 0.150699404 1.683394184 Up 1.29E-06 3.65E-06 MUC6 2 - GO:0005198//structural molecule activity GO:0010669//epithelial structure maintenance gi|151301154|ref|NP_005952.2|/0/mucin-6 precursor [Homo sapiens] 22989 7074 81 390 0.252920045 0.810867795 1.680785331 Up 1.59E-26 1.16E-25 MYH15 1 GO:0016459//myosin complex;GO:0043292//contractile fiber GO:0008092//cytoskeletal protein binding;GO:0017111//nucleoside-triphosphatase activity;GO:0032559 - gi|166997692|dbj|BAA76844.3|/0/KIAA1000 protein [Homo sapiens] 137872 1907 40 192 0.463310973 1.480815788 1.676339426 Up 9.81E-14 4.35E-13 ADHFE1 2 GO:0044429//mitochondrial part "GO:0016614//oxidoreductase activity, acting on CH-OH group of donors;GO:0043169//cation binding" GO:0006818//hydrogen transport;GO:0043648//dicarboxylic acid metabolic process "gi|133922590|ref|NP_653251.2|/0/hydroxyacid-oxoacid transhydrogenase, mitochondrial [Homo sapiens]" 284297 4910 15 72 0.067479686 0.215675843 1.676339426 Up 6.32E-06 1.69E-05 SSC5D 1 GO:0044464//cell part GO:0004888//transmembrane signaling receptor activity - gi|222352122|ref|NP_001138422.1|/0/soluble scavenger receptor cysteine-rich domain-containing protein SSC5D isoform 1 precursor [Homo sapiens]//gi|305410878|ref|NP_001182196.1|/0/soluble scavenger receptor cysteine-rich domain-containing protein SSC5D isoform 2 precursor [Homo sapiens] 28968 2945 69 331 0.51751993 1.653077425 1.67546797 Up 1.21E-22 7.68E-22 SLC6A16 2 GO:0016021//integral to membrane GO:0005326//neurotransmitter transporter activity;GO:0015291//secondary active transmembrane transporter activity GO:0006810//transport gi|55749589|ref|NP_054756.2|/0/orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 [Homo sapiens] 100271715 4316 14 67 0.071648959 0.228319953 1.672039289 Up 1.40E-05 3.63E-05 ARHGEF33 2 - - - gi|290463441|ref|NP_001138923.2|/0/rho guanine nucleotide exchange factor 33 [Homo sapiens] 84432 1372 13 62 0.209291952 0.664642454 1.667061613 Up 3.13E-05 7.84E-05 PROK1 2 - GO:0005102//receptor binding GO:0000165//MAPK cascade;GO:0008283//cell proliferation;GO:0022603//regulation of anatomical structure morphogenesis;GO:0048511//rhythmic process;GO:0048522//positive regulation of cellular process;GO:0048646//anatomical structure formation involved in morphogenesis gi|14165282|ref|NP_115790.1|/7.03955e-59/prokineticin-1 precursor [Homo sapiens] 340037 1600 13 62 0.179467849 0.569930904 1.667061613 Up 3.13E-05 7.84E-05 PRR7-AS1 1 - - - gi|34527111|dbj|BAC85329.1|/1.05466e-25/unnamed protein product [Homo sapiens]//gi|34527111|dbj|BAC85329.1|/1.25717e-25/unnamed protein product [Homo sapiens] 497258 2322 17 81 0.161714884 0.51306608 1.665692182 Up 1.79E-06 5.01E-06 BDNF-AS 1 GO:0031410//cytoplasmic vesicle GO:0005102//receptor binding GO:0006935//chemotaxis;GO:0007405//neuroblast proliferation;GO:0007610//behavior;GO:0008037//cell recognition;GO:0008152//metabolic process;GO:0023061;GO:0031175//neuron projection development;GO:0033555//multicellular organismal response to stress;GO:0035295//tube development;GO:0043066//negative regulation of apoptotic process;GO:0045597//positive regulation of cell differentiation;GO:0050804//regulation of synaptic transmission "gi|119588686|gb|EAW68280.1|/1.6049e-59/hCG2039157, isoform CRA_a [Homo sapiens]//gi|119588686|gb|EAW68280.1|/9.16008e-60/hCG2039157, isoform CRA_a [Homo sapiens]//gi|119588687|gb|EAW68281.1|/5.43038e-42/hCG2039157, isoform CRA_b [Homo sapiens]//gi|119588687|gb|EAW68281.1|/6.3775e-42/hCG2039157, isoform CRA_b [Homo sapiens]//gi|119588687|gb|EAW68281.1|/9.8756e-42/hCG2039157, isoform CRA_b [Homo sapiens]" 144406 3785 37 176 0.21592311 0.683907371 1.663283273 Up 1.40E-12 5.84E-12 WDR66 5 - GO:0046872//metal ion binding - gi|145279222|ref|NP_653269.3|/0/WD repeat-containing protein 66 isoform 1 [Homo sapiens]//gi|295821176|ref|NP_001171474.1|/0/WD repeat-containing protein 66 isoform 2 [Homo sapiens] 282808 1029 16 76 0.34345346 1.086297344 1.661232534 Up 3.96E-06 1.08E-05 RAB40AL 1 GO:0016020//membrane;GO:0043231//intracellular membrane-bounded organelle GO:0032561//guanyl ribonucleotide binding GO:0006810//transport;GO:0035556//intracellular signal transduction gi|73611940|ref|NP_001027004.1|/1.35593e-159/ras-related protein Rab-40A-like [Homo sapiens] 94086 616 16 76 0.573723393 1.814610336 1.661232534 Up 3.96E-06 1.08E-05 HSPB9 2 GO:0043231//intracellular membrane-bounded organelle GO:0005488//binding GO:0050896//response to stimulus gi|15082238|ref|NP_149971.1|/4.52058e-87/heat shock protein beta-9 [Homo sapiens] 2810 1336 24 114 0.396796718 1.255014933 1.661232534 Up 1.37E-08 4.51E-08 SFN 3 GO:0043231//intracellular membrane-bounded organelle;GO:0044421//extracellular region part GO:0005515//protein binding;GO:0030291//protein serine/threonine kinase inhibitor activity GO:0008283//cell proliferation;GO:0008629;GO:0008637//apoptotic mitochondrial changes;GO:0009913//epidermal cell differentiation;GO:0010466//negative regulation of peptidase activity;GO:0016049//cell growth;GO:0023052//signaling;GO:0033673//negative regulation of kinase activity;GO:0051726//regulation of cell cycle gi|5454052|ref|NP_006133.1|/1.52519e-127/14-3-3 protein sigma [Homo sapiens] 124751 1964 105 495 1.180894509 3.706928555 1.650344218 Up 1.85E-32 1.59E-31 KRBA2 2 GO:0044464//cell part GO:0003676//nucleic acid binding "GO:0006259//DNA metabolic process;GO:0006351//transcription, DNA-dependent" gi|47106061|ref|NP_998762.1|/0/KRAB-A domain-containing protein 2 [Homo sapiens] 220979 3212 28 132 0.192551002 0.604434013 1.650344218 Up 1.14E-09 4.01E-09 C10orf25 2 - - - gi|282847365|ref|NP_001034469.2|/1.72392e-70/uncharacterized protein C10orf25 precursor [Homo sapiens] 50939 8365 24 113 0.06337363 0.198684047 1.648521482 Up 1.89E-08 6.17E-08 IMPG2 3 GO:0031012//extracellular matrix;GO:0031224//intrinsic to membrane GO:0004871//signal transducer activity;GO:0005198//structural molecule activity;GO:0005539//glycosaminoglycan binding GO:0050953//sensory perception of light stimulus gi|57242793|ref|NP_057331.2|/0/interphotoreceptor matrix proteoglycan 2 precursor [Homo sapiens] 9077 1642 20 94 0.269042029 0.841986641 1.645965777 Up 3.19E-07 9.52E-07 DIRAS3 2 GO:0016020//membrane GO:0017111//nucleoside-triphosphatase activity;GO:0032561//guanyl ribonucleotide binding "GO:0009207;GO:0035556//intracellular signal transduction;GO:0040029//regulation of gene expression, epigenetic;GO:0051726//regulation of cell cycle" gi|4757772|ref|NP_004666.1|/5.29901e-120/GTP-binding protein Di-Ras3 [Homo sapiens] 56924 3961 33 155 0.184023118 0.575542443 1.645035306 Up 4.36E-11 1.68E-10 PAK6 1 - GO:0004672//protein kinase activity;GO:0032559 GO:0006464//cellular protein modification process gi|9910476|ref|NP_064553.1|/0/serine/threonine-protein kinase PAK 6 [Homo sapiens] 7454 1844 29 136 0.347376447 1.084747086 1.642786867 Up 7.18E-10 2.57E-09 WAS 2 GO:0005856//cytoskeleton;GO:0012505//endomembrane system;GO:0044444//cytoplasmic part GO:0005515//protein binding;GO:0030695//GTPase regulator activity GO:0006950//response to stress;GO:0007599//hemostasis;GO:0008154//actin polymerization or depolymerization;GO:0009888//tissue development;GO:0016192//vesicle-mediated transport;GO:0046649//lymphocyte activation;GO:0050851//antigen receptor-mediated signaling pathway;GO:0065003 gi|12804207|gb|AAH02961.1|/6.47322e-162/WAS protein [Homo sapiens] 8288 2731 16 75 0.129408133 0.403915076 1.642123711 Up 5.49E-06 1.47E-05 EPX 4 - GO:0003824//catalytic activity;GO:0005506//iron ion binding;GO:0016209//antioxidant activity GO:0006950//response to stress;GO:0042743//hydrogen peroxide metabolic process gi|4503595|ref|NP_000493.1|/0/eosinophil peroxidase preproprotein [Homo sapiens] 9806 5463 106 496 0.428585972 1.335368035 1.639580876 Up 3.07E-32 2.62E-31 SPOCK2 2 GO:0031012//extracellular matrix GO:0046872//metal ion binding GO:0007399//nervous system development;GO:0023052//signaling;GO:0043062//extracellular structure organization;GO:0050793//regulation of developmental process gi|40788936|dbj|BAA13404.2|/0/KIAA0275 [Homo sapiens]//gi|40788936|dbj|BAA13404.2|/1.40386e-64/KIAA0275 [Homo sapiens] 27076 1745 51 238 0.64556211 2.006005069 1.635697442 Up 3.50E-16 1.74E-15 LYPD3 2 GO:0031225//anchored to membrane GO:0005515//protein binding GO:0031589//cell-substrate adhesion gi|93004088|ref|NP_055215.2|/5.65914e-168/ly6/PLAUR domain-containing protein 3 precursor [Homo sapiens] 91181 5455 16 74 0.059768918 0.184066325 1.622758386 Up 7.59E-06 2.01E-05 NUP210L 1 GO:0031224//intrinsic to membrane - - gi|117414168|ref|NP_997191.2|/0/nuclear pore membrane glycoprotein 210-like isoform 1 precursor [Homo sapiens]//gi|226958663|ref|NP_001152956.1|/0/nuclear pore membrane glycoprotein 210-like isoform 2 precursor [Homo sapiens] 220004 1558 15 69 0.212660629 0.651376577 1.614938882 Up 1.68E-05 4.31E-05 PPP1R32 1 - - - "gi|119594352|gb|EAW73946.1|/0/hCG2017012, isoform CRA_a [Homo sapiens]//gi|283046778|ref|NP_659454.2|/0/protein phosphatase 1 regulatory subunit 32 isoform 1 [Homo sapiens]" 646903 1964 59 271 0.663550248 2.029449774 1.612811012 Up 6.67E-18 3.57E-17 LOC646903 1 GO:0044424//intracellular part GO:0005488//binding GO:0030036//actin cytoskeleton organization gi|119599255|gb|EAW78849.1|/8.52309e-67/hCG2022540 [Homo sapiens] 2242 2783 40 183 0.317475395 0.967137858 1.607076764 Up 1.76E-12 7.29E-12 FES 1 GO:0044444//cytoplasmic part GO:0004713//protein tyrosine kinase activity;GO:0032559 GO:0006468//protein phosphorylation;GO:0006935//chemotaxis;GO:0032501//multicellular organismal process gi|219842230|ref|NP_001137255.1|/0/tyrosine-protein kinase Fes/Fps isoform 2 [Homo sapiens]//gi|219842233|ref|NP_001137256.1|/0/tyrosine-protein kinase Fes/Fps isoform 3 [Homo sapiens]//gi|219842236|ref|NP_001137257.1|/0/tyrosine-protein kinase Fes/Fps isoform 4 [Homo sapiens] //gi|4503687|ref|NP_001996.1|/0/tyrosine-protein kinase Fes/Fps isoform 1 [Homo sapiens] 283624 5439 2579 11766 10.47359004 31.81707748 1.603045284 Up 0 0 LOC283624 1 - - - "gi|119577128|gb|EAW56724.1|/1.1006e-14/GLI-Kruppel family member HKR1, isoform CRA_d [Homo sapiens]//gi|119586805|gb|EAW66401.1|/3.09313e-22/hCG2038558 [Homo sapiens]" 144321 2448 25 114 0.225575476 0.684926451 1.602338845 Up 3.12E-08 1.00E-07 GLIPR1L2 1 GO:0031224//intrinsic to membrane - - gi|22748923|ref|NP_689649.1|/2.64515e-128/GLIPR1-like protein 2 isoform 2 [Homo sapiens]//gi|394025727|ref|NP_001257325.1|/2.17959e-149/GLIPR1-like protein 2 isoform 1 [Homo sapiens]//gi|394025727|ref|NP_001257325.1|/6.19229e-118/GLIPR1-like protein 2 isoform 1 [Homo sapiens] 4703 26202 206 937 0.173658508 0.525963551 1.598709731 Up 1.90E-57 2.81E-56 NEB 4 GO:0031674//I band - - gi|115527120|ref|NP_004534.2|/0/nebulin isoform 3 [Homo sapiens]//gi|257743023|ref|NP_001157979.1|/0/nebulin isoform 1 [Homo sapiens]//gi|257743025|ref|NP_001157980.1|/0/nebulin isoform 2 [Homo sapiens] 168507 9075 31 141 0.075453319 0.22851935 1.598660062 Up 7.44E-10 2.66E-09 PKD1L1 3 GO:0031224//intrinsic to membrane - GO:0007155//cell adhesion gi|19923084|ref|NP_612152.1|/0/polycystic kidney disease protein 1-like 1 [Homo sapiens] 161253 1885 13 59 0.152333453 0.46035319 1.595508352 Up 8.34E-05 0.000200132 REM2 2 GO:0016020//membrane GO:0005515//protein binding;GO:0017111//nucleoside-triphosphatase activity;GO:0032559;GO:0032561//guanyl ribonucleotide binding "GO:0006351//transcription, DNA-dependent;GO:0009207;GO:0035556//intracellular signal transduction" gi|124248562|ref|NP_775798.2|/2.3652e-159/GTP-binding protein REM 2 [Homo sapiens] 5199 1785 18 81 0.22273967 0.667417053 1.583230022 Up 4.07E-06 1.11E-05 CFP 1 GO:0044421//extracellular region part - GO:0006952//defense response;GO:0006956//complement activation gi|4505737|ref|NP_002612.1|/0/properdin precursor [Homo sapiens] 149297 1481 12 54 0.178973807 0.536277038 1.583230022 Up 0.00018617 0.00042964 FAM78B 3 - - - gi|63003925|ref|NP_780670.2|/2.97399e-151/protein FAM78B [Mus musculus] 149483 2267 28 126 0.272815976 0.817465674 1.583230022 Up 7.72E-09 2.59E-08 CCDC17 1 - - - gi|298104089|ref|NP_001177111.1|/0/coiled-coil domain-containing protein 17 isoform 2 [Homo sapiens]//gi|298104091|ref|NP_001108410.2|/0/coiled-coil domain-containing protein 17 isoform 1 [Homo sapiens] 5016 2258 116 519 1.134742547 3.380601039 1.574914754 Up 6.89E-32 5.84E-31 OVGP1 3 GO:0016023//cytoplasmic membrane-bounded vesicle "GO:0004553//hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0043167//ion binding" GO:0006026;GO:0009566//fertilization gi|58386720|ref|NP_002548.3|/0/oviduct-specific glycoprotein precursor [Homo sapiens] 8741 2293 72 322 0.693572283 2.065391176 1.574296897 Up 2.41E-20 1.41E-19 TNFSF13 2 GO:0031981//nuclear lumen;GO:0044421//extracellular region part GO:0032813//tumor necrosis factor receptor superfamily binding GO:0008283//cell proliferation;GO:0016070//RNA metabolic process;GO:0023052//signaling;GO:0045830//positive regulation of isotype switching gi|26051246|ref|NP_742084.1|/1.99149e-115/tumor necrosis factor ligand superfamily member 13 isoform beta proprotein [Homo sapiens]//gi|26051248|ref|NP_742085.1|/4.09923e-123/tumor necrosis factor ligand superfamily member 13 isoform gamma proprotein [Homo sapiens]//gi|310750385|ref|NP_001185551.1|/3.57206e-109/tumor necrosis factor ligand superfamily member 13 isoform delta [Homo sapiens]//gi|310750387|ref|NP_001185552.1|/1.35511e-108/tumor necrosis factor ligand superfamily member 13 isoform zeta [Homo sapiens] //gi|310750387|ref|NP_001185552.1|/4.80888e-104/tumor necrosis factor ligand superfamily member 13 isoform zeta [Homo sapiens] //gi|4507599|ref|NP_003799.1|/8.2347e-125/tumor necrosis factor ligand superfamily member 13 isoform alpha proprotein [Homo sapiens] 10297 10151 97 432 0.211069846 0.625929499 1.56827968 Up 1.20E-26 8.76E-26 APC2 2 GO:0005874//microtubule;GO:0012505//endomembrane system;GO:0015629//actin cytoskeleton;GO:0019897//extrinsic to plasma membrane;GO:0030027//lamellipodium;GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part GO:0015631//tubulin binding GO:0030178//negative regulation of Wnt receptor signaling pathway;GO:0035411//catenin import into nucleus "gi|119589902|gb|EAW69496.1|/0/adenomatosis polyposis coli 2, isoform CRA_a [Homo sapiens]" 80108 2405 47 209 0.431664232 1.278149651 1.566075301 Up 1.31E-13 5.78E-13 ZFP2 2 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding GO:0010467//gene expression gi|297295868|ref|XP_001097848.2|/0/PREDICTED: zinc finger protein 2 homolog isoform 1 [Macaca mulatta] 8557 963 27 120 0.61929955 1.832759415 1.565308114 Up 2.31E-08 7.48E-08 TCAP 3 GO:0031674//I band GO:0005198//structural molecule activity;GO:0008092//cytoskeletal protein binding;GO:0019904//protein domain specific binding GO:0006941//striated muscle contraction;GO:0007015//actin filament organization;GO:0007507//heart development;GO:0009612//response to mechanical stimulus;GO:0009952//anterior/posterior pattern specification;GO:0014866//skeletal myofibril assembly;GO:0048747//muscle fiber development;GO:0060415//muscle tissue morphogenesis;GO:0065003 gi|4507435|ref|NP_003664.1|/2.69845e-82/telethonin [Homo sapiens] 10903 2879 135 598 1.035751071 3.054991593 1.560491098 Up 4.78E-36 4.52E-35 MTMR11 1 - GO:0042578//phosphoric ester hydrolase activity - gi|224994251|ref|NP_001139334.1|/0/myotubularin-related protein 11 isoform a [Homo sapiens]//gi|89111941|ref|NP_870988.2|/0/myotubularin-related protein 11 isoform b [Homo sapiens] 348 1223 38 168 0.686310158 2.020381229 1.55769493 Up 3.98E-11 1.54E-10 APOE 2 GO:0005768//endosome;GO:0009897//external side of plasma membrane;GO:0015630//microtubule cytoskeleton;GO:0034385;GO:0043005//neuron projection;GO:0044297//cell body GO:0005539//glycosaminoglycan binding;GO:0008047//enzyme activator activity;GO:0008092//cytoskeletal protein binding;GO:0008289//lipid binding;GO:0015248//sterol transporter activity;GO:0042802//identical protein binding;GO:0046872//metal ion binding;GO:0046983//protein dimerization activity;GO:0070325//lipoprotein particle receptor binding;GO:0071814 GO:0001558//regulation of cell growth;GO:0001935//endothelial cell proliferation;GO:0006182//cGMP biosynthetic process;GO:0006639//acylglycerol metabolic process;GO:0006875//cellular metal ion homeostasis;GO:0006897//endocytosis;GO:0006979//response to oxidative stress;GO:0006996//organelle organization;GO:0007166//cell surface receptor signaling pathway;GO:0007266//Rho protein signal transduction;GO:0008203//cholesterol metabolic process;GO:0010467//gene expression;GO:0010543//regulation of platelet activation;GO:0010596//negative regulation of endothelial cell migration;GO:0010872//regulation of cholesterol esterification;GO:0010874//regulation of cholesterol efflux;GO:0010894//negative regulation of steroid biosynthetic process;GO:0012502//induction of programmed cell death;GO:0015914//phospholipid transport;GO:0019935//cyclic-nucleotide-mediated signaling;GO:0031103//axon regeneration;GO:0031331;GO:0031348//negative regulation of defense response;GO:0032770//positive regulation of monooxygenase activity;GO:0034370//triglyceride-rich lipoprotein particle remodeling;GO:0034377;GO:0034645//cellular macromolecule biosynthetic process;GO:0042157//lipoprotein metabolic process;GO:0043066//negative regulation of apoptotic process;GO:0043405//regulation of MAP kinase activity;GO:0048167//regulation of synaptic plasticity;GO:0048514//blood vessel morphogenesis;GO:0050880//regulation of blood vessel size;GO:0055092//sterol homeostasis;GO:0070848//response to growth factor stimulus;GO:0071830 gi|4557325|ref|NP_000032.1|/1.25413e-157/apolipoprotein E precursor [Homo sapiens] 8578 3864 19 84 0.10861249 0.319736833 1.55769493 Up 3.48E-06 9.54E-06 SCARF1 1 GO:0031224//intrinsic to membrane GO:0004888//transmembrane signaling receptor activity;GO:0071813//lipoprotein particle binding GO:0006897//endocytosis;GO:0008203//cholesterol metabolic process;GO:0010975//regulation of neuron projection development;GO:0023052//signaling;GO:0032103;GO:0042551//neuron maturation gi|145309306|ref|NP_663327.2|/0/scavenger receptor class F member 1 isoform 5 precursor [Homo sapiens]//gi|33598929|ref|NP_003684.2|/0/scavenger receptor class F member 1 isoform 1 precursor [Homo sapiens]//gi|33598931|ref|NP_663325.1|/0/scavenger receptor class F member 1 isoform 3 precursor [Homo sapiens] 1821 7118 81 357 0.251356617 0.737667641 1.553235282 Up 5.35E-22 3.34E-21 DRP2 2 GO:0005626//insoluble fraction;GO:0016020//membrane;GO:0043005//neuron projection;GO:0043232 GO:0046914//transition metal ion binding GO:0007399//nervous system development;GO:0043062//extracellular structure organization gi|133777549|gb|AAI11696.2|/0/Dystrophin related protein 2 [Homo sapiens]//gi|148539558|ref|NP_001930.2|/0/dystrophin-related protein 2 isoform 1 [Homo sapiens] 653659 1706 32 141 0.414318417 1.215599705 1.552856373 Up 1.64E-09 5.75E-09 TMEM183B 1 GO:0031224//intrinsic to membrane - - gi|119369512|ref|NP_001073277.1|/0/transmembrane protein 183B [Homo sapiens] 389813 2931 39 171 0.293908452 0.858085952 1.545755316 Up 3.41E-11 1.33E-10 C9orf172 2 - - - gi|148762978|ref|NP_001073951.2|/0/uncharacterized protein C9orf172 [Homo sapiens] 23166 7965 24 105 0.066556235 0.193889379 1.542588037 Up 2.40E-07 7.23E-07 STAB1 2 GO:0016021//integral to membrane GO:0004888//transmembrane signaling receptor activity;GO:0005539//glycosaminoglycan binding;GO:0015036//disulfide oxidoreductase activity;GO:0030169//low-density lipoprotein particle binding;GO:0043498//cell surface binding GO:0001525//angiogenesis;GO:0006897//endocytosis;GO:0006952//defense response;GO:0007154//cell communication gi|20521856|dbj|BAA13377.2|/0/KIAA0246 protein [Homo sapiens] 80759 1443 91 398 1.392959048 4.056647217 1.542135001 Up 4.04E-24 2.72E-23 KHDC1 1 GO:0031224//intrinsic to membrane GO:0003676//nucleic acid binding - gi|353523794|ref|NP_001238803.1|/8.17151e-138/KH homology domain-containing protein 1 isoform 1 [Homo sapiens]//gi|353523794|ref|NP_001238803.1|/8.65334e-97/KH homology domain-containing protein 1 isoform 1 [Homo sapiens] 55138 2516 27 118 0.237037149 0.689797905 1.541060568 Up 4.31E-08 1.37E-07 FAM90A1 3 - GO:0046914//transition metal ion binding - gi|144953905|ref|NP_060558.3|/0/protein FAM90A1 [Homo sapiens] 51315 1774 425 1857 5.29174127 15.39603141 1.540744089 Up 1.85E-106 5.24E-105 KRCC1 1 - - - gi|7706156|ref|NP_057702.1|/3.80332e-119/lysine-rich coiled-coil protein 1 [Homo sapiens] 79690 2561 30 131 0.258746786 0.752336647 1.539837426 Up 7.76E-09 2.60E-08 GAL3ST4 4 GO:0000139//Golgi membrane;GO:0005626//insoluble fraction;GO:0031224//intrinsic to membrane GO:0030554//adenyl nucleotide binding;GO:0050694//galactose 3-O-sulfotransferase activity GO:0005975//carbohydrate metabolic process;GO:0006029//proteoglycan metabolic process;GO:0007154//cell communication gi|62087868|dbj|BAD92381.1|/0/galactose-3-O-sulfotransferase 4 variant [Homo sapiens] 2661 2020 37 161 0.4045886 1.172262863 1.534768533 Up 1.60E-10 5.95E-10 GDF9 3 GO:0044421//extracellular region part GO:0005102//receptor binding GO:0003006//developmental process involved in reproduction;GO:0007178//transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007276//gamete generation;GO:0016049//cell growth gi|4885261|ref|NP_005251.1|/0/growth/differentiation factor 9 preproprotein [Homo sapiens] 2979 2287 20 87 0.193164413 0.559504506 1.534320421 Up 2.96E-06 8.17E-06 GUCA1B 5 GO:0016020//membrane GO:0030250//guanylate cyclase activator activity;GO:0046872//metal ion binding GO:0007154//cell communication;GO:0007167//enzyme linked receptor protein signaling pathway;GO:0030826//regulation of cGMP biosynthetic process;GO:0046903//secretion;GO:0050953//sensory perception of light stimulus gi|153945858|ref|NP_002089.4|/2.09707e-112/guanylyl cyclase-activating protein 2 [Homo sapiens] 26038 9663 61 265 0.139437999 0.403352167 1.532416232 Up 2.08E-16 1.04E-15 CHD5 2 GO:0043231//intracellular membrane-bounded organelle;GO:0044427//chromosomal part "GO:0003676//nucleic acid binding;GO:0032559;GO:0042623//ATPase activity, coupled;GO:0046914//transition metal ion binding" GO:0006325//chromatin organization gi|24308089|ref|NP_056372.1|/0/chromodomain-helicase-DNA-binding protein 5 [Homo sapiens] 100861532 13357 5022 21687 8.304836177 23.88037013 1.523801583 Up 0 0 RN45S 1 - GO:0001071//nucleic acid binding transcription factor activity;GO:0005515//protein binding "GO:0006351//transcription, DNA-dependent" gi|68226711|ref|NP_001020173.1|/6.24964e-80/uncharacterized protein LOC310926 [Rattus norvegicus] 57538 10936 60 259 0.121187 0.348330708 1.523222712 Up 6.07E-16 2.99E-15 ALPK3 4 GO:0043231//intracellular membrane-bounded organelle GO:0004672//protein kinase activity;GO:0032559 GO:0006464//cellular protein modification process;GO:0048513//organ development gi|115511036|ref|NP_065829.3|/0/alpha-protein kinase 3 [Homo sapiens] 144193 2143 20 86 0.206144196 0.590237476 1.51764168 Up 4.05E-06 1.10E-05 AMDHD1 2 GO:0044444//cytoplasmic part "GO:0016812//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0043169//cation binding" GO:0006536//glutamate metabolic process;GO:0006547//histidine metabolic process gi|51555810|dbj|BAD38660.1|/0/putative protein product of HMFT1272 [Homo sapiens] 51655 1814 14 60 0.170472386 0.486479415 1.512840694 Up 0.000133477 0.000312348 RASD1 1 GO:0000267//cell fraction;GO:0016020//membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part GO:0017111//nucleoside-triphosphatase activity;GO:0032561//guanyl ribonucleotide binding "GO:0006355//regulation of transcription, DNA-dependent;GO:0007166//cell surface receptor signaling pathway;GO:0009207;GO:0035556//intracellular signal transduction" gi|7706359|ref|NP_057168.1|/6.38148e-138/dexamethasone-induced Ras-related protein 1 isoform 1 proprotein [Homo sapiens]//gi|8118457|gb|AAF72997.1|AF262018_1/1.15463e-118/dexamethasone-induced ras-related protein 1 [Homo sapiens] 151649 2130 14 60 0.145181647 0.414306882 1.512840694 Up 0.000133477 0.000312386 PP2D1 1 - - - gi|119584708|gb|EAW64304.1|/0/chromosome 3 open reading frame 48 [Homo sapiens]//gi|358030299|ref|NP_001239586.1|/0/protein phosphatase 2C-like domain-containing protein 1 [Homo sapiens] 285755 4223 103 439 0.538740259 1.528952309 1.504881623 Up 1.38E-25 9.81E-25 PPIL6 2 - GO:0016859//cis-trans isomerase activity GO:0044267//cellular protein metabolic process gi|27735045|ref|NP_775943.1|/0/peptidyl-prolyl cis-trans isomerase-like 6 isoform 1 [Homo sapiens]//gi|289803023|ref|NP_001104768.2|/0/peptidyl-prolyl cis-trans isomerase-like 6 isoform 2 [Homo sapiens] 126248 1724 16 68 0.204996293 0.580125762 1.500767862 Up 5.09E-05 0.000124904 WDR88 3 - - - gi|102470001|ref|NP_775750.3|/0/WD repeat-containing protein 88 [Homo sapiens] 728118 3308 262 1113 1.749440103 4.948575079 1.500119896 Up 3.90E-62 6.21E-61 FAM22A 1 - - - gi|150170710|ref|NP_001092808.1|/0/protein FAM22A [Homo sapiens] 54757 4511 26 110 0.127310378 0.358649606 1.494225016 Up 2.36E-07 7.11E-07 FAM20A 1 - - - gi|149635068|ref|XP_001509531.1|/0/PREDICTED: protein FAM20A-like [Ornithorhynchus anatinus]//gi|241896898|ref|NP_060035.2|/0/protein FAM20A isoform a precursor [Homo sapiens] 314 2681 179 757 1.474753734 4.152881757 1.493638733 Up 1.55E-42 1.71E-41 AOC2 3 GO:0016020//membrane;GO:0044424//intracellular part "GO:0016641//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor;GO:0046914//transition metal ion binding;GO:0048037//cofactor binding" GO:0006576//cellular biogenic amine metabolic process;GO:0050953//sensory perception of light stimulus gi|60498982|ref|NP_001149.2|/0/retina-specific copper amine oxidase isoform a precursor [Homo sapiens]//gi|60498984|ref|NP_033720.2|/0/retina-specific copper amine oxidase isoform b precursor [Homo sapiens] 3429 665 22 93 0.730742427 2.056893489 1.493032213 Up 2.13E-06 5.93E-06 IFI27 3 GO:0044464//cell part - GO:0043065//positive regulation of apoptotic process;GO:0050794//regulation of cellular process "gi|194272171|ref|NP_001123552.1|/4.53537e-09/interferon alpha-inducible protein 27, mitochondrial isoform 1 [Homo sapiens]//gi|55925614|ref|NP_005523.3|/1.19333e-14/interferon alpha-inducible protein 27, mitochondrial isoform 2 [Homo sapiens]" 8705 1704 31 131 0.401842059 1.130712532 1.492531712 Up 1.66E-08 5.44E-08 B3GALT4 3 GO:0012505//endomembrane system;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle GO:0035250//UDP-galactosyltransferase activity GO:0006464//cellular protein modification process "gi|4502341|ref|NP_003773.1|/0/beta-1,3-galactosyltransferase 4 [Homo sapiens]" 23615 1071 14 59 0.288736609 0.810238809 1.488593148 Up 0.000182206 0.000420899 PYY2 2 - - - "gi|119571449|gb|EAW51064.1|/2.83078e-30/peptide YY, 2 (seminalplasmin) [Homo sapiens]" 202915 6293 14 59 0.049139823 0.137893813 1.488593148 Up 0.000182206 0.00042095 TMEM184A 1 GO:0031224//intrinsic to membrane - - gi|74711763|sp|Q6ZTR0.1|YG017_HUMAN/0/RecName: Full=Putative uncharacterized protein MGC9712 5803 8169 15 63 0.040558852 0.113428491 1.483694348 Up 0.00011224 0.000265158 PTPRZ1 2 GO:0016021//integral to membrane;GO:0031012//extracellular matrix GO:0004725//protein tyrosine phosphatase activity;GO:0005488//binding GO:0006464//cellular protein modification process;GO:0006796//phosphate-containing compound metabolic process;GO:0048667//cell morphogenesis involved in neuron differentiation gi|332205943|ref|NP_001193767.1|/0/receptor-type tyrosine-protein phosphatase zeta isoform 2 precursor [Homo sapiens]//gi|332205945|ref|NP_001193768.1|/0/receptor-type tyrosine-protein phosphatase zeta isoform 3 precursor [Homo sapiens]//gi|91208428|ref|NP_002842.2|/0/receptor-type tyrosine-protein phosphatase zeta isoform 1 precursor [Homo sapiens] 54954 8090 511 2123 1.395197425 3.859685984 1.468014195 Up 2.48E-113 7.53E-112 FAM120C 4 - - - gi|157388908|ref|NP_060318.3|/0/constitutive coactivator of PPAR-gamma-like protein 2 isoform 1 [Homo sapiens]//gi|296278244|ref|NP_940858.1|/1.03302e-68/constitutive coactivator of PPAR-gamma-like protein 2 isoform 2 [Homo sapiens] 130132 3131 39 162 0.275134358 0.760996128 1.467752804 Up 5.29E-10 1.91E-09 RFTN2 2 GO:0016020//membrane - - gi|188528644|ref|NP_653230.2|/0/raftlin-2 [Homo sapiens] 219731 3163 14 58 0.097766964 0.269698979 1.463931093 Up 0.000248024 0.000562438 LOC219731 1 - - - "gi|119606740|gb|EAW86334.1|/9.6097e-66/hCG2017698, isoform CRA_a [Homo sapiens]" 219293 3859 15 62 0.085857802 0.236302008 1.460610735 Up 0.000152597 0.000355041 ATAD3C 2 - GO:0016462//pyrophosphatase activity;GO:0032559 - "gi|56204889|emb|CAI22067.1|/0/ATPase family, AAA domain containing 3C [Homo sapiens]" 51168 11876 27 111 0.050217705 0.13746853 1.452833385 Up 3.65E-07 1.08E-06 MYO15A 3 GO:0005902//microvillus;GO:0015629//actin cytoskeleton GO:0008092//cytoskeletal protein binding;GO:0017111//nucleoside-triphosphatase activity;GO:0032559 GO:0007610//behavior;GO:0042471//ear morphogenesis;GO:0050954//sensory perception of mechanical stimulus gi|118402590|ref|NP_057323.3|/0/unconventional myosin-XV [Homo sapiens] 51265 2138 47 193 0.485571786 1.327700468 1.451173206 Up 1.71E-11 6.72E-11 CDKL3 3 GO:0044424//intracellular part GO:0004674//protein serine/threonine kinase activity;GO:0032559 GO:0006464//cellular protein modification process gi|166064027|ref|NP_001107047.1|/0/cyclin-dependent kinase-like 3 isoform 1 [Homo sapiens] 10411 6239 29 119 0.102670647 0.280532044 1.450141789 Up 1.42E-07 4.35E-07 RAPGEF3 2 GO:0005626//insoluble fraction;GO:0016020//membrane;GO:0043234//protein complex GO:0016208//AMP binding;GO:0019887//protein kinase regulator activity;GO:0030695//GTPase regulator activity GO:0006468//protein phosphorylation;GO:0007599//hemostasis;GO:0009966//regulation of signal transduction;GO:0015980//energy derivation by oxidation of organic compounds;GO:0030073//insulin secretion gi|148747859|ref|NP_001092001.1|/0/rap guanine nucleotide exchange factor 3 isoform a [Homo sapiens] 414245 2858 21 86 0.162300687 0.442574846 1.447252352 Up 8.52E-06 2.25E-05 DNAJC9-AS1 1 - - - gi|172049034|sp|A6NH13.2|DAS1_HUMAN/4.58493e-43/RecName: Full=Putative uncharacterized protein DNAJC9-AS1; AltName: Full=DNAJC9 antisense RNA 1; AltName: Full=DNAJC9 antisense gene protein 1 100507043 3214 25 102 0.171813555 0.466772004 1.441874173 Up 1.27E-06 3.61E-06 LINC00617 1 - - - "gi|148686815|gb|EDL18762.1|/8.12889e-20/mCG53020, isoform CRA_a [Mus musculus]" 100505696 5592 655 2661 2.587244216 6.998874598 1.435706719 Up 4.47E-137 1.64E-135 LOC100505696 1 GO:0043231//intracellular membrane-bounded organelle GO:0019887//protein kinase regulator activity;GO:0019904//protein domain specific binding GO:0007165//signal transduction gi|397511821|ref|XP_003826263.1|/4.72068e-34/PREDICTED: SH3 domain-binding protein 5 [Pan paniscus] 26206 2010 17 69 0.186816896 0.504897864 1.434366636 Up 7.86E-05 0.000189065 SPAG8 1 GO:0030141//secretory granule - - gi|27502373|ref|NP_758516.1|/0/sperm-associated antigen 8 isoform 2 [Homo sapiens]//gi|88853066|ref|NP_001034681.1|/3.03533e-166/sperm-associated antigen 8 isoform 1 [Homo sapiens] 728658 658 17 69 0.570671673 1.542317184 1.434366636 Up 7.86E-05 0.000189041 RPL13AP5 1 GO:0030529//ribonucleoprotein complex;GO:0044444//cytoplasmic part GO:0005198//structural molecule activity GO:0006412//translation;GO:0019080;GO:0031016//pancreas development gi|6912634|ref|NP_036555.1|/5.27843e-103/60S ribosomal protein L13a isoform 1 [Homo sapiens] 4883 7450 18 73 0.053367827 0.144117622 1.433204578 Up 4.85E-05 0.000119375 NPR3 1 GO:0005626//insoluble fraction;GO:0031224//intrinsic to membrane GO:0001653//peptide receptor activity;GO:0042802//identical protein binding GO:0003014//renal system process;GO:0007188//adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0008015//blood circulation;GO:0031280;GO:0033687//osteoblast proliferation;GO:0048731;GO:0070661//leukocyte proliferation gi|324120921|ref|NP_001191304.1|/0/atrial natriuretic peptide receptor 3 isoform 1 precursor [Homo sapiens]//gi|324120923|ref|NP_001191305.1|/9.17184e-175/atrial natriuretic peptide receptor 3 isoform 3 [Homo sapiens] //gi|4505441|ref|NP_000899.1|/0/atrial natriuretic peptide receptor 3 isoform 2 precursor [Homo sapiens] 338321 3484 20 81 0.126798798 0.341945878 1.431226928 Up 1.86E-05 4.74E-05 NLRP9 2 GO:0044424//intracellular part GO:0032559 - "gi|33519450|ref|NP_789790.2|/0/NACHT, LRR and PYD domains-containing protein 9 [Homo sapiens]" 81575 4752 138 558 0.641454627 1.727063347 1.428901875 Up 7.08E-30 5.70E-29 APOLD1 1 - - GO:0007275//multicellular organismal development;GO:0009987//cellular process gi|194353993|ref|NP_110444.3|/4.10989e-84/apolipoprotein L domain-containing protein 1 isoform 2 [Homo sapiens]//gi|27503692|gb|AAH42478.1|/2.53649e-97/APOLD1 protein [Homo sapiens] 6853 3210 15 60 0.103216592 0.274913912 1.41330502 Up 0.000279734 0.000630518 SYN1 2 GO:0000267//cell fraction;GO:0000794//condensed nuclear chromosome;GO:0008021//synaptic vesicle;GO:0044459//plasma membrane part GO:0003824//catalytic activity;GO:0008092//cytoskeletal protein binding;GO:0032559 GO:0001505//regulation of neurotransmitter levels;GO:0051234//establishment of localization gi|19924097|ref|NP_598006.1|/0/synapsin-1 isoform Ib [Homo sapiens] 7881 4518 49 195 0.239559358 0.634802875 1.40592549 Up 3.91E-11 1.51E-10 KCNAB1 3 GO:0031224//intrinsic to membrane;GO:0044424//intracellular part GO:0003824//catalytic activity;GO:0005267//potassium channel activity;GO:0005488//binding;GO:0016247//channel regulator activity GO:0008152//metabolic process;GO:0030001//metal ion transport;GO:0034220//ion transmembrane transport gi|27436962|ref|NP_003462.2|/0/voltage-gated potassium channel subunit beta-1 isoform 2 [Homo sapiens]//gi|27436966|ref|NP_751892.1|/0/voltage-gated potassium channel subunit beta-1 isoform 1 [Homo sapiens]//gi|8393643|ref|NP_058999.1|/0/voltage-gated potassium channel subunit beta-1 [Rattus norvegicus] 388730 1350 113 449 1.848876756 4.891736699 1.403697693 Up 9.53E-24 6.33E-23 TMEM81 1 GO:0031224//intrinsic to membrane - - gi|42794618|ref|NP_976310.1|/4.08808e-120/transmembrane protein 81 precursor [Homo sapiens] 100131320 2474 68 270 0.607117155 1.605146105 1.402657776 Up 7.62E-15 3.56E-14 LOC100131320 1 GO:0000267//cell fraction;GO:0031982//vesicle;GO:0044431//Golgi apparatus part GO:0008047//enzyme activator activity;GO:0017111//nucleoside-triphosphatase activity;GO:0019899//enzyme binding;GO:0032561//guanyl ribonucleotide binding "GO:0000301//retrograde transport, vesicle recycling within Golgi;GO:0006479//protein methylation;GO:0007265//Ras protein signal transduction;GO:0009207;GO:0015031//protein transport;GO:0033365//protein localization to organelle;GO:0042221//response to chemical stimulus;GO:0072384//organelle transport along microtubule" gi|6808528|gb|AAF28422.1|AF124200_1/3.76814e-30/Rab6-like protein [Homo sapiens] 90226 1546 33 131 0.471484845 1.246270475 1.402333903 Up 7.02E-08 2.20E-07 UCN2 3 - GO:0005515//protein binding GO:0009987//cellular process gi|119585296|gb|EAW64892.1|/5.2312e-21/hCG2045959 [Homo sapiens] 146456 940 31 123 0.728445606 1.924543617 1.401623215 Up 1.80E-07 5.47E-07 TMED6 3 GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle - GO:0051234//establishment of localization gi|269914167|ref|NP_653277.2|/9.33665e-141/transmembrane emp24 domain-containing protein 6 precursor [Homo sapiens] 51561 1049 22 87 0.463244722 1.219815829 1.396816898 Up 1.29E-05 3.35E-05 IL23A 2 GO:0043234//protein complex;GO:0044421//extracellular region part GO:0005126//cytokine receptor binding GO:0001787//natural killer cell proliferation;GO:0001818//negative regulation of cytokine production;GO:0001819//positive regulation of cytokine production;GO:0001912//positive regulation of leukocyte mediated cytotoxicity;GO:0002763//positive regulation of myeloid leukocyte differentiation;GO:0002824;GO:0010455//positive regulation of cell fate commitment;GO:0010534;GO:0031349//positive regulation of defense response;GO:0034103//regulation of tissue remodeling;GO:0042345//regulation of NF-kappaB import into nucleus;GO:0042503//tyrosine phosphorylation of Stat3 protein;GO:0042504;GO:0042506//tyrosine phosphorylation of Stat5 protein;GO:0042508//tyrosine phosphorylation of Stat1 protein;GO:0042742//defense response to bacterium;GO:0046641//positive regulation of alpha-beta T cell proliferation;GO:0050691//regulation of defense response to virus by host gi|11528343|gb|AAG37232.1|AF301620_1/1.86853e-87/interleukin 23 p19 subunit [Homo sapiens] 439965 3294 22 87 0.147523896 0.388459868 1.396816898 Up 1.29E-05 3.35E-05 FAM35B2 1 - - - gi|10434681|dbj|BAB14342.1|/0/unnamed protein product [Homo sapiens] 56 1189 15 59 0.278658755 0.729828229 1.389057474 Up 0.000377124 0.000836575 ACRV1 4 GO:0030141//secretory granule - GO:0032501//multicellular organismal process gi|4501879|ref|NP_001603.1|/5.08029e-140/acrosomal protein SP-10 isoform a precursor [Homo sapiens]//gi|9955927|ref|NP_064454.1|/3.77116e-129/acrosomal protein SP-10 isoform b precursor [Homo sapiens]//gi|9955929|ref|NP_064492.1|/4.54475e-115/acrosomal protein SP-10 isoform c precursor [Homo sapiens]//gi|9955931|ref|NP_064493.1|/1.05063e-105/acrosomal protein SP-10 isoform d precursor [Homo sapiens] 11213 8351 28 110 0.074059851 0.19373349 1.387309812 Up 9.97E-07 2.86E-06 IRAK3 2 GO:0043231//intracellular membrane-bounded organelle GO:0004672//protein kinase activity;GO:0032559;GO:0042802//identical protein binding;GO:0046872//metal ion binding;GO:0046983//protein dimerization activity GO:0001959//regulation of cytokine-mediated signaling pathway;GO:0002224//toll-like receptor signaling pathway;GO:0002237//response to molecule of bacterial origin;GO:0002645;GO:0002719;GO:0009895;GO:0031348//negative regulation of defense response;GO:0043241//protein complex disassembly;GO:0043331//response to dsRNA;GO:0043405//regulation of MAP kinase activity;GO:0043433//negative regulation of sequence-specific DNA binding transcription factor activity;GO:0051091//positive regulation of sequence-specific DNA binding transcription factor activity gi|216547504|ref|NP_001135995.1|/0/interleukin-1 receptor-associated kinase 3 isoform b [Homo sapiens]//gi|216547519|ref|NP_009130.2|/0/interleukin-1 receptor-associated kinase 3 isoform a [Homo sapiens] 57468 6084 27 106 0.098025225 0.256251939 1.386337973 Up 1.60E-06 4.51E-06 SLC12A5 4 GO:0031224//intrinsic to membrane;GO:0032589//neuron projection membrane;GO:0043025//neuronal cell body GO:0005488//binding;GO:0015377//cation:chloride symporter activity GO:0007267//cell-cell signaling;GO:0007611//learning or memory;GO:0015695//organic cation transport;GO:0015698//inorganic anion transport;GO:0030001//metal ion transport;GO:0040007//growth;GO:0042221//response to chemical stimulus;GO:0045851//pH reduction gi|158260539|dbj|BAF82447.1|/0/unnamed protein product [Homo sapiens]//gi|198041678|ref|NP_001128243.1|/0/solute carrier family 12 member 5 isoform 1 [Homo sapiens] 441549 1330 38 149 0.631095732 1.647726505 1.384546027 Up 1.20E-08 3.96E-08 CDNF 2 - GO:0005102//receptor binding - gi|82880674|ref|NP_001025125.2|/1.38012e-104/cerebral dopamine neurotrophic factor precursor [Homo sapiens] 285962 2262 46 180 0.449188386 1.170389467 1.381596161 Up 3.77E-10 1.37E-09 FLJ40852 1 GO:0005815//microtubule organizing center;GO:0031981//nuclear lumen GO:0004713//protein tyrosine kinase activity;GO:0032559;GO:0046872//metal ion binding GO:0000087//M phase of mitotic cell cycle;GO:0006464//cellular protein modification process gi|74729241|sp|Q8N7M3.1|YG005_HUMAN/9.13907e-68/RecName: Full=Putative uncharacterized protein FLJ40852 6543 5111 22 86 0.095078011 0.247481689 1.380138156 Up 1.73E-05 4.42E-05 SLC8A2 2 GO:0015630//microtubule cytoskeleton;GO:0030425//dendrite;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0044297//cell body GO:0005515//protein binding;GO:0015081//sodium ion transmembrane transporter activity;GO:0015291//secondary active transmembrane transporter activity GO:0001775//cell activation;GO:0007204//elevation of cytosolic calcium ion concentration;GO:0007599//hemostasis;GO:0030900//forebrain development;GO:0033273//response to vitamin;GO:0070838//divalent metal ion transport gi|5689511|dbj|BAA83039.1|/0/KIAA1087 protein [Homo sapiens] 54863 4069 173 676 0.939121321 2.443484038 1.379556229 Up 4.06E-34 3.65E-33 TOR4A 2 GO:0031224//intrinsic to membrane GO:0016462//pyrophosphatase activity;GO:0032559 GO:0051084//'de novo' posttranslational protein folding gi|116063568|ref|NP_060193.2|/0/torsin-4A [Homo sapiens] 720 5426 21 82 0.085487535 0.222271901 1.378539602 Up 2.79E-05 7.02E-05 C4A 2 GO:0044421//extracellular region part GO:0061135 GO:0002455//humoral immune response mediated by circulating immunoglobulin;GO:0006952//defense response gi|356582273|ref|NP_001239133.1|/0/complement C4-A isoform 2 preproprotein [Homo sapiens]//gi|68533033|dbj|BAE06071.1|/0/C4A variant protein [Homo sapiens] 81027 3496 162 631 1.023544851 2.654657125 1.374951212 Up 8.42E-32 7.10E-31 TUBB1 3 GO:0015630//microtubule cytoskeleton;GO:0032991//macromolecular complex GO:0005198//structural molecule activity;GO:0017111//nucleoside-triphosphatase activity;GO:0032561//guanyl ribonucleotide binding GO:0006458//'de novo' protein folding;GO:0007051//spindle organization;GO:0009207;GO:0043623//cellular protein complex assembly gi|13562114|ref|NP_110400.1|/0/tubulin beta-1 chain [Homo sapiens] 11126 1559 19 74 0.269197346 0.698129685 1.374830873 Up 7.30E-05 0.000176496 CD160 2 GO:0031225//anchored to membrane GO:0004888//transmembrane signaling receptor activity;GO:0005515//protein binding GO:0002682//regulation of immune system process;GO:0006952//defense response;GO:0007165//signal transduction gi|157849872|gb|ABV89736.1|/5.90977e-97/CD160 transmembrane isoform [Homo sapiens] 126549 3217 75 292 0.514959993 1.335003151 1.374310889 Up 1.66E-15 8.02E-15 ANKLE1 4 GO:0012505//endomembrane system - - "gi|119604994|gb|EAW84588.1|/0/ankyrin repeat domain 41, isoform CRA_c [Homo sapiens]" 22973 1543 23 89 0.329249556 0.848349056 1.365476495 Up 1.44E-05 3.71E-05 LAMB2P1 1 GO:0005604//basement membrane - GO:0022008//neurogenesis;GO:0048468//cell development;GO:0048513//organ development;GO:0071842 gi|31982223|ref|NP_032509.2|/4.3369e-37/laminin subunit beta-2 precursor [Mus musculus] 149069 1367 28 108 0.452431468 1.161998965 1.3608376 Up 1.78E-06 4.99E-06 DCDC2B 1 - - GO:0007165//signal transduction gi|150456471|ref|NP_001092904.1|/0/doublecortin domain-containing protein 2B [Homo sapiens] 135154 526 83 320 3.485424147 8.947768399 1.360193684 Up 1.28E-16 6.48E-16 C6orf57 2 GO:0043231//intracellular membrane-bounded organelle - - gi|46275839|ref|NP_660310.2|/9.11697e-60/UPF0369 protein C6orf57 precursor [Homo sapiens] 728743 3369 69 266 0.452388303 1.161264436 1.360062999 Up 4.73E-14 2.12E-13 LOC728743 1 - - - gi|297289638|ref|XP_001098218.2|/3.73286e-99/PREDICTED: zinc finger protein 615-like [Macaca mulatta] 9992 809 26 100 0.709885187 1.818033907 1.356721492 Up 4.59E-06 1.24E-05 KCNE2 1 GO:0000323//lytic vacuole;GO:0005887//integral to plasma membrane GO:0005267//potassium channel activity;GO:0016247//channel regulator activity GO:0003012//muscle system process;GO:0003013;GO:0030001//metal ion transport;GO:0034220//ion transmembrane transport;GO:0044057 gi|27436978|ref|NP_751951.1|/3.2291e-64/potassium voltage-gated channel subfamily E member 2 [Homo sapiens] 6565 5523 36 138 0.143976213 0.367497631 1.351904476 Up 7.24E-08 2.26E-07 SLC15A2 1 GO:0005626//insoluble fraction;GO:0016021//integral to membrane GO:0005488//binding;GO:0015198//oligopeptide transporter activity;GO:0015238//drug transmembrane transporter activity;GO:0015295//solute:hydrogen symporter activity GO:0015833//peptide transport gi|226371746|ref|NP_066568.3|/0/solute carrier family 15 member 2 isoform a [Homo sapiens]//gi|226371748|ref|NP_001139470.1|/0/solute carrier family 15 member 2 isoform b [Homo sapiens] 387849 1139 17 65 0.329676875 0.839344276 1.348209992 Up 0.000256834 0.000581033 REP15 1 GO:0005769//early endosome - - gi|71274164|ref|NP_001025045.1|/1.76204e-134/rab15 effector protein [Homo sapiens] 147670 2542 33 126 0.286748848 0.729030166 1.346190825 Up 2.97E-07 8.88E-07 LOC147670 1 - - - gi|302318930|ref|NP_001180557.1|/8.35345e-41/uncharacterized protein LOC147670 [Homo sapiens] 100533970 6285 145 553 0.509595997 1.294107486 1.344531601 Up 3.45E-27 2.57E-26 P2RX5-TAX1BP3 1 GO:0016021//integral to membrane GO:0005231//excitatory extracellular ligand-gated ion channel activity;GO:0016502;GO:0032559 GO:0009967//positive regulation of signal transduction;GO:0010522//regulation of calcium ion transport into cytosol;GO:0035587;GO:0048731 gi|62088826|dbj|BAD92860.1|/0/purinergic receptor P2X5 isoform A variant [Homo sapiens] 221395 5822 16 61 0.060703128 0.15410195 1.344042358 Up 0.000417314 0.000921331 GPR116 1 GO:0031224//intrinsic to membrane GO:0004888//transmembrane signaling receptor activity GO:0007186//G-protein coupled receptor signaling pathway "gi|119624714|gb|EAX04309.1|/0/G protein-coupled receptor 116, isoform CRA_b [Homo sapiens]//gi|71891679|dbj|BAA34478.2|/0/KIAA0758 protein [Homo sapiens]" 257044 3208 48 183 0.330499012 0.83901018 1.344042358 Up 6.17E-10 2.22E-09 C1orf101 1 GO:0031224//intrinsic to membrane - - "gi|119597517|gb|EAW77111.1|/0/hCG2042312, isoform CRA_c [Homo sapiens]//gi|195972862|ref|NP_001124429.1|/0/uncharacterized protein C1orf101 isoform 1 precursor [Homo sapiens]" 2298 2204 57 216 0.571250447 1.441427028 1.335302508 Up 2.17E-11 8.54E-11 FOXD4 4 GO:0031981//nuclear lumen;GO:0043234//protein complex GO:0000981//sequence-specific DNA binding RNA polymerase II transcription factor activity;GO:0005515//protein binding;GO:0043565//sequence-specific DNA binding;GO:0043566//structure-specific DNA binding GO:0000122//negative regulation of transcription from RNA polymerase II promoter;GO:0001667//ameboidal cell migration;GO:0001822//kidney development;GO:0021782//glial cell development;GO:0030509//BMP signaling pathway;GO:0048675//axon extension;GO:0050931//pigment cell differentiation;GO:0060600 gi|34596581|gb|AAQ76878.1|/0/FOXD4 [Homo sapiens] 284837 4622 122 462 0.583033054 1.470153001 1.334316724 Up 1.01E-22 6.47E-22 LOC284837 1 - - - gi|74711021|sp|Q6ZR03.1|YU004_HUMAN/1.32446e-159/RecName: Full=Uncharacterized protein FLJ46757 80863 1931 67 253 0.766400565 1.927031206 1.330209405 Up 4.87E-13 2.08E-12 PRRT1 3 GO:0031224//intrinsic to membrane - - "gi|119623993|gb|EAX03588.1|/4.29163e-172/proline-rich transmembrane protein 1, isoform CRA_a [Homo sapiens]" 717 2867 62 233 0.47766925 1.195304979 1.323294855 Up 4.94E-12 2.00E-11 C2 1 GO:0044421//extracellular region part GO:0004175//endopeptidase activity GO:0002455//humoral immune response mediated by circulating immunoglobulin;GO:0006952//defense response;GO:0019538//protein metabolic process gi|14550407|ref|NP_000054.2|/0/complement C2 isoform 1 preproprotein [Homo sapiens]//gi|194385074|dbj|BAG60943.1|/0/unnamed protein product [Homo sapiens]//gi|225543438|ref|NP_001139375.1|/0/complement C2 isoform 2 preproprotein [Homo sapiens]//gi|295849303|ref|NP_001171534.1|/0/complement C2 isoform 3 [Homo sapiens] 6094 1894 45 169 0.524802417 1.312372829 1.32233136 Up 4.39E-09 1.49E-08 ROM1 3 GO:0016021//integral to membrane - GO:0009987//cellular process;GO:0050953//sensory perception of light stimulus gi|143745282|sp|Q03395.2|ROM1_HUMAN/1.83427e-143/RecName: Full=Rod outer segment membrane protein 1; Short=ROSP1; AltName: Full=Tetraspanin-23; Short=Tspan-23 100505783 1743 96 357 1.216570086 3.01246028 1.308122784 Up 2.08E-17 1.09E-16 LOC100505783 1 - - - "gi|119596342|gb|EAW75936.1|/6.0481e-32/hCG2018868, isoform CRA_a [Homo sapiens]//gi|119596342|gb|EAW75936.1|/6.96922e-32/hCG2018868, isoform CRA_a [Homo sapiens]//gi|119596342|gb|EAW75936.1|/7.67098e-32/hCG2018868, isoform CRA_a [Homo sapiens]" 4502 466 241 893 11.42337446 28.18487042 1.302932049 Up 5.24E-41 5.59E-40 MT2A 3 - GO:0005488//binding GO:0007165//signal transduction;GO:0042221//response to chemical stimulus gi|5174764|ref|NP_005944.1|/3.67332e-12/metallothionein-2 [Homo sapiens] 114904 2954 242 895 1.809539895 4.456183278 1.300185655 Up 5.73E-41 6.10E-40 C1QTNF6 1 - - - gi|32967294|ref|NP_114116.3|/1.97018e-154/complement C1q tumor necrosis factor-related protein 6 [Homo sapiens]//gi|32967294|ref|NP_114116.3|/3.88646e-154/complement C1q tumor necrosis factor-related protein 6 [Homo sapiens] 5630 1833 72 266 0.86762752 2.134369823 1.298662454 Up 3.35E-13 1.44E-12 PRPH 3 GO:0043234//protein complex - - gi|21264345|ref|NP_006253.2|/0/peripherin [Homo sapiens] 84849 1291 49 181 0.838364973 2.062067288 1.298441063 Up 2.07E-09 7.18E-09 MGC16142 1 - - - "gi|119618124|gb|EAW97718.1|/4.64761e-27/5'-nucleotidase domain containing 3, isoform CRA_d [Homo sapiens]" 643641 6913 759 2802 2.425149446 5.961452314 1.297590185 Up 3.56E-124 1.19E-122 ZNF862 1 GO:0043231//intracellular membrane-bounded organelle GO:0005515//protein binding;GO:0043169//cation binding "GO:0006351//transcription, DNA-dependent" gi|149773449|ref|NP_001092690.1|/0/zinc finger protein 862 [Homo sapiens] 56241 3201 68 251 0.469230816 1.153290057 1.297385733 Up 1.61E-12 6.71E-12 SUSD2 3 GO:0031224//intrinsic to membrane GO:0001871;GO:0004888//transmembrane signaling receptor activity GO:0002376//immune system process;GO:0023052//signaling gi|10092665|ref|NP_062547.1|/0/sushi domain-containing protein 2 precursor [Homo sapiens] 4621 6061 472 1742 1.720128938 4.227215291 1.29719088 Up 7.40E-78 1.49E-76 MYH3 3 GO:0016459//myosin complex;GO:0043292//contractile fiber GO:0003774//motor activity;GO:0008092//cytoskeletal protein binding;GO:0032559 GO:0006936//muscle contraction;GO:0030029//actin filament-based process;GO:0048513//organ development gi|98986453|ref|NP_002461.2|/0/myosin-3 [Homo sapiens] 100509894 3508 19 70 0.119634738 0.293487059 1.294660524 Up 0.000230946 0.000526027 CPB2-AS1 1 - - - "gi|355564236|gb|EHH20736.1|/2.20584e-33/hypothetical protein EGK_03652, partial [Macaca mulatta]//gi|355564236|gb|EHH20736.1|/2.42443e-33/hypothetical protein EGK_03652, partial [Macaca mulatta]" 400684 968 18 66 0.410733793 1.002810975 1.287774138 Up 0.000374048 0.000830235 LOC400684 1 GO:0012505//endomembrane system;GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part;GO:0044459//plasma membrane part "GO:0000166//nucleotide binding;GO:0003779//actin binding;GO:0005506//iron ion binding;GO:0016597//amino acid binding;GO:0016709//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0050662//coenzyme binding" GO:0001990;GO:0006525//arginine metabolic process;GO:0006996//organelle organization;GO:0008283//cell proliferation;GO:0009719;GO:0010033//response to organic substance;GO:0010543//regulation of platelet activation;GO:0014738;GO:0014805//smooth muscle adaptation;GO:0016477//cell migration;GO:0030001//metal ion transport;GO:0031281;GO:0032768;GO:0042311//vasodilation;GO:0043066//negative regulation of apoptotic process;GO:0043269//regulation of ion transport;GO:0044271//cellular nitrogen compound biosynthetic process;GO:0045765//regulation of angiogenesis;GO:0048771//tissue remodeling gi|119575293|gb|EAW54898.1|/1.09498e-06/hCG1811730 [Homo sapiens] 646 4627 161 590 0.768581035 1.8754393 1.286959287 Up 3.78E-27 2.81E-26 BNC1 3 GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding GO:0008283//cell proliferation;GO:0009888//tissue development;GO:0010467//gene expression gi|157276588|ref|NP_001708.3|/0/zinc finger protein basonuclin-1 [Homo sapiens] 4501 468 236 863 11.13856997 27.12160852 1.28387872 Up 7.72E-39 7.84E-38 MT1X 3 - - - "gi|119603291|gb|EAW82885.1|/9.28466e-19/metallothionein 1X, isoform CRA_a [Homo sapiens]" 388722 697 69 252 2.18665164 5.317631801 1.282060487 Up 2.31E-12 9.51E-12 C1orf53 2 - - - gi|66912196|ref|NP_001019765.1|/4.1018e-80/uncharacterized protein C1orf53 [Homo sapiens] 5896 6582 20 73 0.067117443 0.163123106 1.281201484 Up 0.000189229 0.000436222 RAG1 2 GO:0043231//intracellular membrane-bounded organelle GO:0003677//DNA binding;GO:0004518//nuclease activity;GO:0019787//small conjugating protein ligase activity;GO:0042802//identical protein binding;GO:0046914//transition metal ion binding GO:0002329//pre-B cell differentiation;GO:0002562;GO:0006325//chromatin organization;GO:0006513//protein monoubiquitination;GO:0010466//negative regulation of peptidase activity;GO:0030217//T cell differentiation;GO:0070233//negative regulation of T cell apoptotic process gi|313104166|sp|P15918.2|RAG1_HUMAN/0/RecName: Full=V(D)J recombination-activating protein 1; Short=RAG-1; AltName: Full=RING finger protein 74; Includes: RecName: Full=Endonuclease RAG1; Includes: RecName: Full=E3 ubiquitin-protein ligase RAG1 1893 2242 54 197 0.532012013 1.29235289 1.280469338 Up 6.08E-10 2.18E-09 ECM1 2 GO:0031012//extracellular matrix GO:0019899//enzyme binding;GO:0060089 GO:0001935//endothelial cell proliferation;GO:0007249//I-kappaB kinase/NF-kappaB cascade;GO:0009888//tissue development;GO:0030279//negative regulation of ossification;GO:0045765//regulation of angiogenesis;GO:0051346//negative regulation of hydrolase activity gi|221316614|ref|NP_004416.2|/0/extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]//gi|221316616|ref|NP_073155.2|/0/extracellular matrix protein 1 isoform 2 precursor [Homo sapiens]//gi|322302700|ref|NP_001189787.1|/0/extracellular matrix protein 1 isoform 3 precursor [Homo sapiens] 196385 13716 110 401 0.177144836 0.429998951 1.279403733 Up 8.85E-19 4.91E-18 DNAH10 3 GO:0005875//microtubule associated complex;GO:0005930//axoneme GO:0003774//motor activity;GO:0032559 GO:0007017//microtubule-based process "gi|198442844|ref|NP_997320.2|/0/dynein heavy chain 10, axonemal [Homo sapiens]" 162394 4660 239 870 1.132857467 2.745894431 1.277309803 Up 7.57E-39 7.69E-38 SLFN5 3 GO:0043231//intracellular membrane-bounded organelle GO:0032559 GO:0048869//cellular developmental process gi|119600565|gb|EAW80159.1|/0/likely ortholog of mouse schlafen 5 [Homo sapiens] 7292 3493 36 130 0.227649763 0.547387993 1.265747832 Up 6.76E-07 1.96E-06 TNFSF4 3 GO:0016021//integral to membrane;GO:0044421//extracellular region part GO:0032813//tumor necrosis factor receptor superfamily binding GO:0001818//negative regulation of cytokine production;GO:0001819//positive regulation of cytokine production;GO:0016125//sterol metabolic process;GO:0023052//signaling;GO:0031349//positive regulation of defense response;GO:0032496//response to lipopolysaccharide;GO:0034695//response to prostaglandin E stimulus;GO:0042102//positive regulation of T cell proliferation;GO:0043392//negative regulation of DNA binding;GO:0050707//regulation of cytokine secretion;GO:0050714//positive regulation of protein secretion gi|4507603|ref|NP_003317.1|/3.30464e-99/tumor necrosis factor ligand superfamily member 4 [Homo sapiens] 100506757 1333 20 72 0.331408111 0.794424899 1.261301927 Up 0.000250152 0.000566791 LINC00629 1 - - - gi|119632163|gb|EAX11758.1|/4.57346e-23/hCG1818089 [Homo sapiens] 7042 5966 72 259 0.266570775 0.638508988 1.260188307 Up 2.24E-12 9.24E-12 TGFB2 2 GO:0005578//proteinaceous extracellular matrix;GO:0031091//platelet alpha granule;GO:0043005//neuron projection;GO:0044297//cell body;GO:0044421//extracellular region part;GO:0044431//Golgi apparatus part GO:0004674//protein serine/threonine kinase activity;GO:0005160//transforming growth factor beta receptor binding;GO:0042802//identical protein binding;GO:0046983//protein dimerization activity GO:0001775//cell activation;GO:0001837//epithelial to mesenchymal transition;GO:0001944//vasculature development;GO:0002684//positive regulation of immune system process;GO:0002719;GO:0003006//developmental process involved in reproduction;GO:0006606//protein import into nucleus;GO:0006887//exocytosis;GO:0007178//transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007420//brain development;GO:0007423//sensory organ development;GO:0007431//salivary gland development;GO:0007599//hemostasis;GO:0008016//regulation of heart contraction;GO:0008285//negative regulation of cell proliferation;GO:0009611//response to wounding;GO:0009628//response to abiotic stimulus;GO:0009887//organ morphogenesis;GO:0009967//positive regulation of signal transduction;GO:0010523//negative regulation of calcium ion transport into cytosol;GO:0010557//positive regulation of macromolecule biosynthetic process;GO:0010631//epithelial cell migration;GO:0010692;GO:0012502//induction of programmed cell death;GO:0014706//striated muscle tissue development;GO:0014855;GO:0016049//cell growth;GO:0016337//cell-cell adhesion;GO:0017145//stem cell division;GO:0022008//neurogenesis;GO:0022402//cell cycle process;GO:0030198//extracellular matrix organization;GO:0030278//regulation of ossification;GO:0030323//respiratory tube development;GO:0030595//leukocyte chemotaxis;GO:0032872//regulation of stress-activated MAPK cascade;GO:0032906;GO:0033189//response to vitamin A;GO:0033627//cell adhesion mediated by integrin;GO:0034330;GO:0034405//response to fluid shear stress;GO:0035051//cardiocyte differentiation;GO:0035270//endocrine system development;GO:0042417//dopamine metabolic process;GO:0043029//T cell homeostasis;GO:0043065//positive regulation of apoptotic process;GO:0043627//response to estrogen stimulus;GO:0045165//cell fate commitment;GO:0045597//positive regulation of cell differentiation;GO:0045860//positive regulation of protein kinase activity;GO:0048534;GO:0048545//response to steroid hormone stimulus;GO:0048565//digestive tract development;GO:0048598//embryonic morphogenesis;GO:0048646//anatomical structure formation involved in morphogenesis;GO:0048771//tissue remodeling;GO:0048818;GO:0051726//regulation of cell cycle;GO:0060363//cranial suture morphogenesis gi|189053677|dbj|BAG35929.1|/0/unnamed protein product [Homo sapiens]//gi|208022653|ref|NP_001129071.1|/0/transforming growth factor beta-2 isoform 1 precursor [Homo sapiens] 151295 2418 27 97 0.246644114 0.59001892 1.25833036 Up 2.05E-05 5.21E-05 SLC23A3 1 GO:0016020//membrane;GO:0031224//intrinsic to membrane GO:0005488//binding GO:0006810//transport gi|158635944|ref|NP_653313.3|/0/solute carrier family 23 member 3 isoform 1 [Homo sapiens]//gi|222080105|ref|NP_001138361.1|/0/solute carrier family 23 member 3 isoform 2 [Homo sapiens]//gi|222080107|ref|NP_001138362.1|/0/solute carrier family 23 member 3 isoform 3 [Homo sapiens] 7352 2438 85 305 0.770102462 1.839994981 1.256579517 Up 2.86E-14 1.30E-13 UCP3 2 GO:0019866//organelle inner membrane;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle GO:0022857//transmembrane transporter activity GO:0000305//response to oxygen radical;GO:0006818//hydrogen transport;GO:0022900//electron transport chain;GO:0031667//response to nutrient levels;GO:0031960//response to corticosteroid stimulus;GO:0032501//multicellular organismal process;GO:0032502//developmental process;GO:0032787//monocarboxylic acid metabolic process;GO:0043434//response to peptide hormone stimulus;GO:0044238//primary metabolic process;GO:0046907//intracellular transport gi|4507807|ref|NP_003347.1|/2.31771e-156/mitochondrial uncoupling protein 3 isoform UCP3L [Homo sapiens]//gi|4507807|ref|NP_003347.1|/4.05307e-178/mitochondrial uncoupling protein 3 isoform UCP3L [Homo sapiens] 63973 2370 58 208 0.540558792 1.290819416 1.255763743 Up 3.70E-10 1.34E-09 NEUROG2 3 - GO:0003677//DNA binding GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0006935//chemotaxis;GO:0007420//brain development;GO:0016477//cell migration;GO:0021953//central nervous system neuron differentiation;GO:0045597//positive regulation of cell differentiation gi|11875764|gb|AAG40770.1|/3.65437e-75/neurogenin 2 [Homo sapiens] 54457 2371 24 86 0.22358516 0.533479085 1.254607274 Up 6.44E-05 0.000156812 TAF7L 1 GO:0005667//transcription factor complex - "GO:0006352//DNA-dependent transcription, initiation;GO:0048232//male gamete generation;GO:0048869//cellular developmental process" gi|270483792|ref|NP_079161.3|/0/transcription initiation factor TFIID subunit 7-like isoform 1 [Homo sapiens]//gi|270483792|ref|NP_079161.3|/3.05121e-169/transcription initiation factor TFIID subunit 7-like isoform 1 [Homo sapiens] 100529209 1909 72 258 0.833086037 1.987761514 1.254607274 Up 2.93E-12 1.20E-11 RNASEK-C17ORF49 1 GO:0031010;GO:0031224//intrinsic to membrane;GO:0035097//histone methyltransferase complex GO:0003676//nucleic acid binding;GO:0003824//catalytic activity "GO:0006325//chromatin organization;GO:0006351//transcription, DNA-dependent" gi|218563737|ref|NP_001136270.1|/3.73309e-77/chromatin complexes subunit BAP18 isoform 1 [Homo sapiens] 8857 16407 127 455 0.170977054 0.407880289 1.254343069 Up 1.60E-20 9.46E-20 FCGBP 2 - GO:0005488//binding - gi|154146262|ref|NP_003881.2|/0/IgGFc-binding protein precursor [Homo sapiens] 84077 3349 26 93 0.171483164 0.408430627 1.252024113 Up 3.28E-05 8.21E-05 C3orf20 1 GO:0031224//intrinsic to membrane;GO:0044424//intracellular part - - gi|296785031|ref|NP_115513.4|/0/uncharacterized protein C3orf20 isoform 1 [Homo sapiens] 10235 2310 53 189 0.506788997 1.203373171 1.24762699 Up 2.85E-09 9.82E-09 RASGRP2 1 GO:0001726//ruffle;GO:0005624//membrane fraction;GO:0044444//cytoplasmic part;GO:0044459//plasma membrane part GO:0008289//lipid binding;GO:0030695//GTPase regulator activity;GO:0046872//metal ion binding GO:0001775//cell activation;GO:0007264//small GTPase mediated signal transduction;GO:0007599//hemostasis;GO:0009966//regulation of signal transduction;GO:0016049//cell growth gi|6358505|gb|AAF07219.1|AF043722_1/0/guanine exchange factor MCG7 isoform 1 [Homo sapiens]//gi|82571741|gb|AAI10307.1|/0/RASGRP2 protein [Homo sapiens] 100128398 1897 20 71 0.232876654 0.550479966 1.241124045 Up 0.000329818 0.000737734 LOC100128398 1 - - - gi|119592955|gb|EAW72549.1|/8.75843e-53/hCG1811579 [Homo sapiens] 10457 2775 20 71 0.15919532 0.376310089 1.241124045 Up 0.000329818 0.000737821 GPNMB 1 GO:0016021//integral to membrane;GO:0048770 GO:0005102//receptor binding;GO:0005539//glycosaminoglycan binding GO:0001503//ossification;GO:0008283//cell proliferation;GO:0009987//cellular process gi|194388124|dbj|BAG65446.1|/0/unnamed protein product [Homo sapiens] 57822 2879 28 99 0.214822444 0.505759478 1.235306718 Up 2.20E-05 5.59E-05 GRHL3 1 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding GO:0030036//actin cytoskeleton organization gi|303324553|ref|NP_937817.3|/0/grainyhead-like protein 3 homolog isoform 3 [Homo sapiens]//gi|38049007|ref|NP_067003.2|/0/grainyhead-like protein 3 homolog isoform 1 [Homo sapiens]//gi|38049009|ref|NP_937816.1|/0/grainyhead-like protein 3 homolog isoform 2 [Homo sapiens] 114814 6257 258 910 0.910787032 2.139073649 1.2318005 Up 1.91E-38 1.92E-37 GNRHR2 3 GO:0031224//intrinsic to membrane GO:0016500//protein-hormone receptor activity GO:0007166//cell surface receptor signaling pathway gi|16589056|gb|AAL27000.1|AF403014_1/1.1679e-89/type II gonadotropin-releasing hormone receptor [Homo sapiens] 128344 2346 25 88 0.235383105 0.55170277 1.228880449 Up 6.92E-05 0.000167838 C1orf88 4 - - - gi|166197696|ref|NP_857594.2|/5.14384e-114/protein pitchfork [Homo sapiens] 55853 1324 64 224 1.067714834 2.488344656 1.220659942 Up 1.97E-10 7.27E-10 IDI2-AS1 1 GO:0042579//microbody "GO:0016863//intramolecular oxidoreductase activity, transposing C=C bonds;GO:0043169//cation binding" GO:0008203//cholesterol metabolic process;GO:0016109 gi|71152996|sp|Q9NZ38.1|IDAS1_HUMAN/4.46708e-74/RecName: Full=Uncharacterized protein IDI2-AS1; AltName: Full=IDI2 antisense RNA 1; AltName: Full=IDI2 antisense gene protein 1//gi|71152996|sp|Q9NZ38.1|IDAS1_HUMAN/5.69518e-74/RecName: Full=Uncharacterized protein IDI2-AS1; AltName: Full=IDI2 antisense RNA 1; AltName: Full=IDI2 antisense gene protein 1//gi|71152996|sp|Q9NZ38.1|IDAS1_HUMAN/6.73704e-74/RecName: Full=Uncharacterized protein IDI2-AS1; AltName: Full=IDI2 antisense RNA 1; AltName: Full=IDI2 antisense gene protein 1//gi|71152996|sp|Q9NZ38.1|IDAS1_HUMAN/7.36216e-74/RecName: Full=Uncharacterized protein IDI2-AS1; AltName: Full=IDI2 antisense RNA 1; AltName: Full=IDI2 antisense gene protein 1 55259 2651 22 77 0.183305814 0.42720025 1.220659942 Up 0.000219208 0.000500548 CASC1 3 - - - gi|131888105|ref|NP_060742.3|/0/cancer susceptibility candidate protein 1 isoform a [Homo sapiens]//gi|131889097|ref|NP_001076442.1|/0/cancer susceptibility candidate protein 1 isoform b [Homo sapiens]//gi|131889447|ref|NP_001076441.1|/0/cancer susceptibility candidate protein 1 isoform c [Homo sapiens]//gi|211830020|gb|AAI17282.2|/0/CASC1 protein [Homo sapiens] 376940 11557 304 1063 0.581020904 1.352815752 1.219303388 Up 5.88E-44 6.66E-43 ZC3H6 2 - GO:0046914//transition metal ion binding - gi|118766347|ref|NP_940983.2|/0/zinc finger CCCH domain-containing protein 6 [Homo sapiens] 6235 735 9330 32553 280.3868181 651.4096372 1.216146539 Up 0 0 RPS29 3 GO:0005622//intracellular;GO:0015935//small ribosomal subunit GO:0003824//catalytic activity;GO:0005198//structural molecule activity;GO:0046914//transition metal ion binding GO:0006412//translation;GO:0007049//cell cycle;GO:0010467//gene expression;GO:0019080;GO:0031016//pancreas development;GO:0048646//anatomical structure formation involved in morphogenesis;GO:0048863//stem cell differentiation gi|148704682|gb|EDL36629.1|/8.74898e-30/mCG7602 [Mus musculus]//gi|291400443|ref|XP_002716568.1|/2.02075e-43/PREDICTED: ribosomal protein L32-like [Oryctolagus cuniculus] 170954 4615 528 1841 2.527117904 5.867222842 1.215184812 Up 1.74E-74 3.32E-73 PPP1R18 3 GO:0044424//intracellular part - - gi|18916755|dbj|BAB85535.1|/0/KIAA1949 protein [Homo sapiens] 388524 1397 861 3002 13.61350743 31.60565405 1.215143855 Up 2.67E-120 8.69E-119 RPSAP58 2 GO:0005578//proteinaceous extracellular matrix;GO:0005626//insoluble fraction;GO:0015935//small ribosomal subunit;GO:0016020//membrane;GO:0030684//preribosome;GO:0043231//intracellular membrane-bounded organelle;GO:0044297//cell body GO:0004888//transmembrane signaling receptor activity;GO:0005198//structural molecule activity;GO:0005515//protein binding;GO:0043021//ribonucleoprotein complex binding "GO:0000462//maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006412//translation;GO:0007155//cell adhesion;GO:0019080;GO:0022618//ribonucleoprotein complex assembly;GO:0023052//signaling;GO:0030154//cell differentiation;GO:0031016//pancreas development" gi|44890755|gb|AAH66941.1|/3.72043e-156/Ribosomal protein SA [Homo sapiens] 126129 2918 222 774 1.680470815 3.901271485 1.21507891 Up 2.77E-32 2.37E-31 CPT1C 1 GO:0031224//intrinsic to membrane;GO:0031966//mitochondrial membrane GO:0016406 GO:0006520//cellular amino acid metabolic process;GO:0032787//monocarboxylic acid metabolic process "gi|209862905|ref|NP_001129524.1|/0/carnitine O-palmitoyltransferase 1, brain isoform isoform 1 [Homo sapiens]//gi|22748777|ref|NP_689572.1|/0/carnitine O-palmitoyltransferase 1, brain isoform isoform 2 [Homo sapiens]" 440574 3967 2107 7341 11.73182626 27.21720497 1.214091308 Up 6.15E-291 5.11E-289 MINOS1 1 GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle - - gi|323276668|ref|NP_001191011.1|/1.71656e-29/mitochondrial inner membrane organizing system protein 1 isoform b [Homo sapiens]//gi|323276670|ref|NP_001191012.1|/5.33734e-77/mitochondrial inner membrane organizing system protein 1 isoform c [Homo sapiens] //gi|332807837|ref|XP_003307892.1|/1.0973e-45/PREDICTED: UPF0327 protein C1orf151-like isoform 4 [Pan troglodytes]//gi|332807837|ref|XP_003307892.1|/1.82588e-37/PREDICTED: UPF0327 protein C1orf151-like isoform 4 [Pan troglodytes]//gi|332807837|ref|XP_003307892.1|/8.03543e-51/PREDICTED: UPF0327 protein C1orf151-like isoform 4 [Pan troglodytes] 10230 1371 44 153 0.708889444 1.641362384 1.211261244 Up 1.83E-07 5.55E-07 NBR2 1 GO:0043231//intracellular membrane-bounded organelle GO:0032561//guanyl ribonucleotide binding GO:0006810//transport gi|6093476|sp|O15453.1|NBR2_HUMAN/8.01066e-63/RecName: Full=Next to BRCA1 gene 2 protein; AltName: Full=Neighbor of BRCA1 gene 2 protein 8736 5848 21 73 0.079318633 0.183597176 1.210812156 Up 0.00035293 0.000785374 MYOM1 1 GO:0005859//muscle myosin complex;GO:0016459//myosin complex;GO:0031672//A band GO:0005198//structural molecule activity GO:0003012//muscle system process gi|140560917|ref|NP_062830.1|/0/myomesin-1 isoform b [Homo sapiens]//gi|140560919|ref|NP_003794.3|/0/myomesin-1 isoform a [Homo sapiens] 26974 2703 42 146 0.343215215 0.794433063 1.210812156 Up 3.55E-07 1.05E-06 ZNF285 3 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding "GO:0006351//transcription, DNA-dependent" gi|219518988|gb|AAI43985.1|/0/ZNF285A protein [Homo sapiens] 487 3570 172 597 1.064200646 2.459555434 1.208627387 Up 4.59E-25 3.19E-24 ATP2A1 4 GO:0005789//endoplasmic reticulum membrane;GO:0031672//A band;GO:0034703//cation channel complex;GO:0042598 GO:0015144//carbohydrate transmembrane transporter activity;GO:0019829//cation-transporting ATPase activity;GO:0032559;GO:0042802//identical protein binding;GO:0046872//metal ion binding GO:0001775//cell activation;GO:0006915//apoptotic process;GO:0006942//regulation of striated muscle contraction;GO:0007599//hemostasis;GO:0008643//carbohydrate transport;GO:0009206;GO:0009207;GO:0009725//response to hormone stimulus;GO:0031443//fast-twitch skeletal muscle fiber contraction;GO:0032469//endoplasmic reticulum calcium ion homeostasis;GO:0033554//cellular response to stress;GO:0051560//mitochondrial calcium ion homeostasis;GO:0051657;GO:0070588//calcium ion transmembrane transport;GO:0090075 gi|27886529|ref|NP_775293.1|/0/sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform b [Homo sapiens] 729013 1113 203 704 4.02869288 9.303106551 1.207400722 Up 3.11E-29 2.45E-28 LOC729013 1 - - - gi|119588955|gb|EAW68549.1|/7.83513e-39/hCG2039892 [Homo sapiens] 30819 2608 45 156 0.381125682 0.879766684 1.206854143 Up 1.50E-07 4.59E-07 KCNIP2 2 GO:0005887//integral to plasma membrane;GO:0043005//neuron projection;GO:0044424//intracellular part GO:0005048//signal sequence binding;GO:0005515//protein binding;GO:0015271//outward rectifier potassium channel activity;GO:0046872//metal ion binding GO:0003012//muscle system process;GO:0007267//cell-cell signaling;GO:0009593//detection of chemical stimulus;GO:0030001//metal ion transport;GO:0034220//ion transmembrane transport;GO:0044057;GO:0045161//neuronal ion channel clustering;GO:0051259//protein oligomerization gi|21361460|ref|NP_055406.2|/8.89651e-147/Kv channel-interacting protein 2 isoform 1 [Homo sapiens]//gi|27886670|ref|NP_775283.1|/1.39499e-152/Kv channel-interacting protein 2 isoform 2 [Homo sapiens]//gi|27886672|ref|NP_775284.1|/1.07995e-141/Kv channel-interacting protein 2 isoform 3 [Homo sapiens]//gi|27886674|ref|NP_775285.1|/2.33025e-125/Kv channel-interacting protein 2 isoform 4 [Homo sapiens]//gi|27886676|ref|NP_775286.1|/5.45883e-128/Kv channel-interacting protein 2 isoform 5 [Homo sapiens]//gi|27886678|ref|NP_775287.1|/3.44577e-121/Kv channel-interacting protein 2 isoform 6 [Homo sapiens]//gi|27886680|ref|NP_775289.1|/7.55437e-100/Kv channel-interacting protein 2 isoform 7 [Homo sapiens] 282997 2015 90 311 0.986576454 2.270052173 1.202222694 Up 1.17E-13 5.15E-13 LOC282997 1 - - - gi|21756629|dbj|BAC04924.1|/2.76869e-28/unnamed protein product [Homo sapiens] 129881 2187 40 138 0.40399361 0.928070148 1.199901382 Up 8.96E-07 2.58E-06 C2orf77 1 - - - gi|146260271|ref|NP_001078916.1|/0/uncharacterized protein C2orf77 [Homo sapiens] 3108 1122 56 193 1.102448872 2.529967559 1.198407136 Up 5.95E-09 2.01E-08 HLA-DMA 3 GO:0005764//lysosome;GO:0005770//late endosome;GO:0031224//intrinsic to membrane;GO:0042611 - GO:0019221//cytokine-mediated signaling pathway;GO:0019882//antigen processing and presentation;GO:0031294;GO:0050851//antigen receptor-mediated signaling pathway "gi|18765715|ref|NP_006111.2|/3.34719e-138/HLA class II histocompatibility antigen, DM alpha chain precursor [Homo sapiens]" 114625 3485 271 933 1.717630708 3.937579738 1.19688925 Up 1.00E-37 9.85E-37 ERMAP 1 GO:0031224//intrinsic to membrane;GO:0031982//vesicle;GO:0044424//intracellular part - - gi|19923536|ref|NP_061008.2|/0/erythroid membrane-associated protein precursor [Homo sapiens] 414328 1644 48 165 0.644915347 1.476157275 1.194664734 Up 8.27E-08 2.58E-07 IDNK 3 GO:0044424//intracellular part GO:0016301//kinase activity;GO:0032559 GO:0044238//primary metabolic process gi|148744483|gb|AAI42992.1|/1.09345e-92/C9orf103 protein [Homo sapiens]//gi|148744483|gb|AAI42992.1|/1.60663e-92/C9orf103 protein [Homo sapiens]//gi|299758445|ref|NP_001001551.2|/1.03466e-101/probable gluconokinase isoform 1 [Homo sapiens]//gi|299758445|ref|NP_001001551.2|/2.96055e-91/probable gluconokinase isoform 1 [Homo sapiens] 7166 1815 28 96 0.340756924 0.777938211 1.190912599 Up 4.92E-05 0.000120963 TPH1 2 GO:0042995//cell projection;GO:0044444//cytoplasmic part "GO:0016714//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen;GO:0031406//carboxylic acid binding;GO:0046914//transition metal ion binding" GO:0006520//cellular amino acid metabolic process;GO:0009058//biosynthetic process;GO:0042428//serotonin metabolic process;GO:0048771//tissue remodeling;GO:0048856//anatomical structure development;GO:0050896//response to stimulus gi|4759248|ref|NP_004170.1|/0/tryptophan 5-hydroxylase 1 [Homo sapiens] 256949 2801 175 599 1.380029046 3.145315491 1.188506101 Up 1.55E-24 1.06E-23 KANK3 2 - - - gi|157504499|ref|NP_940873.2|/0/KN motif and ankyrin repeat domain-containing protein 3 [Homo sapiens] 402778 3721 36 123 0.213700785 0.486178715 1.185894524 Up 4.40E-06 1.19E-05 IFITM10 3 GO:0031224//intrinsic to membrane - GO:0050896//response to stimulus gi|334848153|ref|NP_001164291.2|/1.02736e-114/interferon-induced transmembrane protein 10 [Homo sapiens] 643669 1074 24 82 0.493594427 1.1229491 1.185894524 Up 0.000190047 0.000438001 LOC643669 1 - - - gi|342349323|ref|NP_001230141.1|/1.43986e-90/uncharacterized protein LOC643669 precursor [Homo sapiens] 57149 1657 692 2357 9.224585775 20.92124736 1.181412836 Up 7.47E-91 1.78E-89 LYRM1 1 GO:0043231//intracellular membrane-bounded organelle - - gi|10092683|ref|NP_065157.1|/3.43466e-64/LYR motif-containing protein 1 [Homo sapiens]//gi|10092683|ref|NP_065157.1|/3.96725e-64/LYR motif-containing protein 1 [Homo sapiens]//gi|10092683|ref|NP_065157.1|/4.17401e-64/LYR motif-containing protein 1 [Homo sapiens] 143689 3214 25 85 0.171813555 0.38897667 1.178839767 Up 0.000154588 0.000359453 PIWIL4 2 GO:0043186//P granule;GO:0043231//intracellular membrane-bounded organelle GO:0003723//RNA binding GO:0006306//DNA methylation;GO:0006412//translation;GO:0016458//gene silencing;GO:0022403;GO:0034660//ncRNA metabolic process;GO:0048232//male gamete generation;GO:0048869//cellular developmental process gi|221316711|ref|NP_689644.2|/0/piwi-like protein 4 [Homo sapiens] 92691 3477 40 136 0.254108146 0.575287209 1.178839767 Up 1.51E-06 4.27E-06 TMEM169 1 GO:0031224//intrinsic to membrane - - gi|19923913|ref|NP_612399.1|/1.89421e-168/transmembrane protein 169 [Homo sapiens]//gi|19923913|ref|NP_612399.1|/1.89806e-168/transmembrane protein 169 [Homo sapiens]//gi|19923913|ref|NP_612399.1|/1.9519e-168/transmembrane protein 169 [Homo sapiens] 54084 3980 30 102 0.166495105 0.376935985 1.178839767 Up 3.27E-05 8.18E-05 TSPEAR 2 - - GO:0009987//cellular process gi|22001420|ref|NP_659428.2|/0/protein TSPEAR precursor [Homo sapiens] 57165 2411 81 275 0.742080631 1.677590599 1.176742826 Up 6.97E-12 2.80E-11 GJC2 3 GO:0005911//cell-cell junction GO:0022829//wide pore channel activity GO:0007154//cell communication gi|45439367|ref|NP_065168.2|/1.17159e-153/gap junction gamma-2 protein [Homo sapiens] 80778 1943 149 505 1.693857047 3.822689977 1.174276078 Up 1.46E-20 8.67E-20 ZNF34 3 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding "GO:0006351//transcription, DNA-dependent" gi|157954634|ref|NP_085057.3|/0/zinc finger protein 34 [Homo sapiens] 100288181 5714 60 203 0.231939278 0.522524071 1.171750342 Up 4.51E-09 1.53E-08 LOC100288181 1 GO:0031224//intrinsic to membrane;GO:0031981//nuclear lumen - - gi|1698455|gb|AAC52011.1|/4.81946e-42/mariner transposase [Homo sapiens] 92973 5245 45 152 0.189509205 0.426234497 1.169379437 Up 4.26E-07 1.26E-06 FP588 1 - - - gi|33341694|gb|AAQ15218.1|AF370382_1/6.14086e-52/FP588 [Homo sapiens] 79369 1554 54 182 0.767548863 1.72254618 1.166212158 Up 3.23E-08 1.04E-07 B3GNT4 2 GO:0012505//endomembrane system;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle "GO:0016758//transferase activity, transferring hexosyl groups" GO:0006464//cellular protein modification process "gi|13540527|ref|NP_110392.1|/0/UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 [Homo sapiens]" 219347 4059 92 309 0.500647513 1.119669707 1.161206092 Up 6.14E-13 2.60E-12 LOC219347 1 - - - "gi|119600821|gb|EAW80415.1|/1.35752e-51/hCG1993682, isoform CRA_a [Homo sapiens]//gi|119600821|gb|EAW80415.1|/3.50288e-36/hCG1993682, isoform CRA_a [Homo sapiens]//gi|119600822|gb|EAW80416.1|/5.05836e-29/hCG1993682, isoform CRA_b [Homo sapiens]//gi|119600822|gb|EAW80416.1|/5.1916e-29/hCG1993682, isoform CRA_b [Homo sapiens]//gi|119600822|gb|EAW80416.1|/5.22835e-29/hCG1993682, isoform CRA_b [Homo sapiens]" 6218 511 67 225 2.89612425 6.476078706 1.160997021 Up 8.65E-10 3.08E-09 RPS17 3 GO:0015935//small ribosomal subunit GO:0003824//catalytic activity;GO:0005198//structural molecule activity GO:0006412//translation;GO:0019080;GO:0022618//ribonucleoprotein complex assembly;GO:0031016//pancreas development;GO:0042254//ribosome biogenesis;GO:0048872//homeostasis of number of cells gi|26377673|dbj|BAC25377.1|/1.22566e-71/unnamed protein product [Mus musculus] 286016 2017 95 319 1.040353648 2.326136978 1.160862026 Up 2.63E-13 1.14E-12 TPI1P2 3 GO:0000267//cell fraction;GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part "GO:0016861//intramolecular oxidoreductase activity, interconverting aldoses and ketoses" GO:0006007//glucose catabolic process;GO:0006631//fatty acid metabolic process;GO:0007275//multicellular organismal development gi|205830477|sp|Q7Z6K2.2|TPISL_HUMAN/4.74551e-122/RecName: Full=Putative triosephosphate isomerase-like protein LOC286016 43847 1133 29 97 0.565368198 1.259193069 1.155236867 Up 6.77E-05 0.000164209 KLK14 4 GO:0044421//extracellular region part GO:0004175//endopeptidase activity GO:0008277//regulation of G-protein coupled receptor protein signaling pathway;GO:0019538//protein metabolic process;GO:0019953//sexual reproduction;GO:0048609//multicellular organismal reproductive process;GO:0048729//tissue morphogenesis gi|91823048|ref|NP_071329.2|/1.33199e-150/kallikrein-14 preproprotein [Homo sapiens] 30816 3044 69 230 0.500688631 1.111306074 1.150270615 Up 7.48E-10 2.67E-09 ERVW-1 1 GO:0031224//intrinsic to membrane;GO:0044423 - GO:0009987//cellular process;GO:0032502//developmental process gi|48949851|ref|NP_055405.3|/0/HERV-W_7q21.2 provirus ancestral Env polyprotein precursor [Homo sapiens] 152273 5897 24 80 0.089896628 0.199530532 1.150270615 Up 0.000321676 0.000720368 FGD5 3 GO:0031252//cell leading edge;GO:0043231//intracellular membrane-bounded organelle;GO:0043232 GO:0005088//Ras guanyl-nucleotide exchange factor activity;GO:0043169//cation binding;GO:0051020//GTPase binding GO:0007010//cytoskeleton organization;GO:0030035//microspike assembly;GO:0032319//regulation of Rho GTPase activity;GO:0065008 "gi|194018497|ref|NP_689749.3|/0/FYVE, RhoGEF and PH domain-containing protein 5 [Homo sapiens]" 100506472 3566 91 303 0.563667949 1.249717323 1.148684364 Up 1.60E-12 6.63E-12 LOC100506472 1 - - - "gi|119580729|gb|EAW60325.1|/1.43762e-57/mitogen-activated protein kinase kinase kinase 7 interacting protein 1, isoform CRA_a [Homo sapiens]" 84101 3476 529 1760 3.36154703 7.447035092 1.147540822 Up 2.54E-65 4.26E-64 USP44 1 GO:0043231//intracellular membrane-bounded organelle GO:0016790//thiolester hydrolase activity;GO:0019783//small conjugating protein-specific protease activity;GO:0046914//transition metal ion binding GO:0000087//M phase of mitotic cell cycle;GO:0031577//spindle checkpoint;GO:0032435//negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0070646//protein modification by small protein removal gi|109134332|ref|NP_115523.2|/0/ubiquitin carboxyl-terminal hydrolase 44 [Homo sapiens] 825 3316 70 232 0.466280019 1.02902035 1.142002999 Up 7.88E-10 2.81E-09 CAPN3 2 GO:0043231//intracellular membrane-bounded organelle GO:0004197//cysteine-type endopeptidase activity;GO:0046872//metal ion binding;GO:0060089 GO:0010038//response to metal ion;GO:0010927;GO:0019538//protein metabolic process;GO:0023052//signaling;GO:0031032//actomyosin structure organization;GO:0048513//organ development "gi|209574304|gb|ACI63188.1|/3.22819e-98/calpain 3 transcription variant 11 [Homo sapiens]//gi|209574304|gb|ACI63188.1|/7.41587e-162/calpain 3 transcription variant 11 [Homo sapiens]//gi|27765072|ref|NP_077320.1|/0/calpain-3 isoform b [Homo sapiens]//gi|27765074|ref|NP_775110.1|/0/calpain-3 isoform c [Homo sapiens]//gi|380800759|gb|AFE72255.1|/1.21073e-97/calpain-3 isoform d, partial [Macaca mulatta]//gi|4557405|ref|NP_000061.1|/0/calpain-3 isoform a [Homo sapiens]" 285267 4201 211 698 1.109412516 2.443730118 1.139289058 Up 1.30E-26 9.49E-26 ZNF619 1 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding - gi|223029403|ref|NP_001138565.1|/0/zinc finger protein 619 isoform 2 [Homo sapiens]//gi|223029512|ref|NP_001138554.1|/0/zinc finger protein 619 isoform 1 [Homo sapiens]//gi|223029514|ref|NP_001138555.1|/0/zinc finger protein 619 isoform 5 [Homo sapiens] 199800 2112 199 658 2.08124137 4.582289041 1.138624174 Up 3.73E-25 2.60E-24 C19orf76 1 - - - gi|119572907|gb|EAW52522.1|/4.58509e-82/hCG1998069 [Homo sapiens] 64170 2147 57 188 0.586416388 1.287882687 1.135003858 Up 3.78E-08 1.21E-07 CARD9 3 GO:0044424//intracellular part GO:0019904//protein domain specific binding;GO:0042802//identical protein binding GO:0001819//positive regulation of cytokine production;GO:0002252;GO:0006915//apoptotic process;GO:0007249//I-kappaB kinase/NF-kappaB cascade;GO:0031349//positive regulation of defense response;GO:0032494//response to peptidoglycan;GO:0032663;GO:0032675//regulation of interleukin-6 production;GO:0032680//regulation of tumor necrosis factor production;GO:0032872//regulation of stress-activated MAPK cascade;GO:0042742//defense response to bacterium;GO:0043331//response to dsRNA;GO:0043410//positive regulation of MAPK cascade;GO:0051091//positive regulation of sequence-specific DNA binding transcription factor activity "gi|119608629|gb|EAW88223.1|/0/caspase recruitment domain family, member 9, isoform CRA_d [Homo sapiens]//gi|47717131|ref|NP_434700.2|/0/caspase recruitment domain-containing protein 9 isoform 1 [Homo sapiens]" 399972 753 34 112 0.997349165 2.18762837 1.133197101 Up 2.41E-05 6.10E-05 FLJ39051 1 - - - gi|119588096|gb|EAW67692.1|/1.56764e-22/hCG2032840 [Homo sapiens] 253724 4516 51 168 0.249447715 0.547149301 1.133197101 Up 2.11E-07 6.37E-07 GNN 1 - - - gi|193806376|sp|Q6P2S7.3|GNN_HUMAN/0/RecName: Full=Tetratricopeptide repeat protein GNN; Short=TPR repeat protein GNN; AltName: Full=Grp94-neighboring nucleotidase 6327 4922 24 79 0.10770427 0.236067381 1.132123268 Up 0.000416922 0.000920679 SCN2B 4 GO:0005887//integral to plasma membrane GO:0005272//sodium channel activity GO:0006814//sodium ion transport;GO:0007267//cell-cell signaling;GO:0017085//response to insecticide;GO:0034220//ion transmembrane transport;GO:0048731 gi|4759066|ref|NP_004579.1|/1.30202e-96/sodium channel subunit beta-2 precursor [Homo sapiens] 6768 3319 24 79 0.159722933 0.35008245 1.132123268 Up 0.000416922 0.000920572 ST14 3 GO:0016021//integral to membrane;GO:0019898//extrinsic to membrane;GO:0044421//extracellular region part;GO:0044459//plasma membrane part GO:0004175//endopeptidase activity GO:0019538//protein metabolic process;GO:0048870//cell motility gi|11415040|ref|NP_068813.1|/0/suppressor of tumorigenicity 14 protein [Homo sapiens] 54752 1369 38 125 0.61311711 1.342941409 1.131161792 Up 8.21E-06 2.17E-05 FNDC8 2 - - - gi|8922138|ref|NP_060029.1|/4.11192e-176/fibronectin type III domain-containing protein 8 [Homo sapiens] 57333 1882 44 144 0.516412023 1.12536492 1.123798403 Up 1.87E-06 5.23E-06 RCN3 2 GO:0044432//endoplasmic reticulum part GO:0046872//metal ion binding - gi|28626510|ref|NP_065701.2|/0/reticulocalbin-3 precursor [Homo sapiens] 1056 2384 52 170 0.481792883 1.048801188 1.122256238 Up 2.21E-07 6.67E-07 CEL 3 GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part GO:0004091//carboxylesterase activity;GO:0005539//glycosaminoglycan binding GO:0006464//cellular protein modification process;GO:0006631//fatty acid metabolic process;GO:0006639//acylglycerol metabolic process;GO:0007589//body fluid secretion;GO:0008203//cholesterol metabolic process;GO:0030301//cholesterol transport;GO:0044240//multicellular organismal lipid catabolic process gi|148536848|ref|NP_001798.2|/0/bile salt-activated lipase precursor [Homo sapiens] 10692 1558 30 98 0.425321257 0.925143544 1.121124269 Up 9.19E-05 0.000219386 RRH 2 GO:0016021//integral to membrane GO:0004888//transmembrane signaling receptor activity GO:0006464//cellular protein modification process;GO:0007166//cell surface receptor signaling pathway;GO:0050953//sensory perception of light stimulus gi|5730019|ref|NP_006574.1|/7.05859e-175/visual pigment-like receptor peropsin [Homo sapiens] 6752 2996 116 378 0.855223188 1.855668908 1.117566449 Up 1.10E-14 5.07E-14 SSTR2 2 GO:0005626//insoluble fraction;GO:0016021//integral to membrane;GO:0044424//intracellular part GO:0008188//neuropeptide receptor activity;GO:0019904//protein domain specific binding GO:0006950//response to stress;GO:0007188//adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007267//cell-cell signaling;GO:0008283//cell proliferation;GO:0014821;GO:0022037//metencephalon development;GO:0031667//response to nutrient levels;GO:0032355//response to estradiol stimulus;GO:0048232//male gamete generation;GO:0051384//response to glucocorticoid stimulus gi|4557859|ref|NP_001041.1|/0/somatostatin receptor type 2 [Homo sapiens] 644128 5811 851 2773 3.234759315 7.018583877 1.1175216 Up 9.19E-98 2.41E-96 RPL23AP53 2 GO:0015934//large ribosomal subunit;GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex GO:0003723//RNA binding;GO:0005198//structural molecule activity GO:0006412//translation;GO:0019080;GO:0031016//pancreas development gi|158259651|dbj|BAF85784.1|/1.91357e-43/unnamed protein product [Homo sapiens] 375190 1386 83 269 1.322751155 2.854562459 1.109727952 Up 9.51E-11 3.58E-10 FAM228B 1 - - - gi|224589111|ref|NP_001139182.1|/0/UPF0638 protein B [Homo sapiens] 4987 3391 72 233 0.468994764 1.010598459 1.107566164 Up 1.83E-09 6.37E-09 OPRL1 1 GO:0016021//integral to membrane GO:0004985//opioid receptor activity GO:0007188//adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0050877//neurological system process;GO:0051480//cytosolic calcium ion homeostasis gi|4505513|ref|NP_000904.1|/2.52965e-162/nociceptin receptor [Homo sapiens]//gi|4505513|ref|NP_000904.1|/2.6466e-162/nociceptin receptor [Homo sapiens]//gi|4505513|ref|NP_000904.1|/2.65198e-162/nociceptin receptor [Homo sapiens] 100287482 1068 60 194 1.240918574 2.671658704 1.106327267 Up 4.35E-08 1.38E-07 LOC100287482 1 - - - gi|119604128|gb|EAW83722.1|/1.30908e-27/hCG2038584 [Homo sapiens] 6876 1574 125 403 1.754157451 3.765744222 1.102156764 Up 2.96E-15 1.41E-14 TAGLN 1 GO:0044424//intracellular part GO:0003779//actin binding GO:0006996//organelle organization;GO:0048513//organ development "gi|119587704|gb|EAW67300.1|/1.92871e-115/transgelin, isoform CRA_c [Homo sapiens]//gi|119587704|gb|EAW67300.1|/8.3154e-115/transgelin, isoform CRA_c [Homo sapiens]" 8870 1254 339 1090 5.971252679 12.78437384 1.098275977 Up 1.89E-38 1.90E-37 IER3 3 GO:0031224//intrinsic to membrane GO:0005488//binding GO:0032502//developmental process;GO:0043066//negative regulation of apoptotic process gi|119964723|ref|NP_003888.2|/1.98828e-73/radiation-inducible immediate-early gene IEX-1 [Homo sapiens] 142684 1354 61 196 0.995117716 2.129060033 1.097277527 Up 4.54E-08 1.44E-07 RAB40A 2 GO:0016020//membrane;GO:0043231//intracellular membrane-bounded organelle GO:0032561//guanyl ribonucleotide binding GO:0006810//transport;GO:0035556//intracellular signal transduction gi|56550077|ref|NP_543155.2|/5.50905e-149/ras-related protein Rab-40A [Homo sapiens] 100131089 2819 152 488 1.191000104 2.546098766 1.096114845 Up 5.09E-18 2.73E-17 LOC100131089 1 - - - "gi|355755615|gb|EHH59362.1|/3.09731e-33/hypothetical protein EGM_09449, partial [Macaca fascicularis]//gi|355755615|gb|EHH59362.1|/3.48862e-33/hypothetical protein EGM_09449, partial [Macaca fascicularis]" 90853 3888 62 199 0.352231929 0.752796031 1.095733331 Up 3.70E-08 1.18E-07 SPOCD1 4 - - - gi|47271475|ref|NP_653170.3|/0/SPOC domain-containing protein 1 [Homo sapiens] 150678 759 1435 4594 41.76124261 89.02248543 1.09200514 Up 5.70E-155 2.41E-153 MYEOV2 1 - - - gi|19923883|ref|NP_612209.1|/3.03947e-22/myeloma-overexpressed gene 2 protein isoform 1 [Homo sapiens]//gi|19923883|ref|NP_612209.1|/8.53187e-133/myeloma-overexpressed gene 2 protein isoform 1 [Homo sapiens] 100505894 739 100 320 2.988951369 6.368776966 1.091376925 Up 3.10E-12 1.27E-11 TMEM161B-AS1 1 - - - - 150384 1532 41 131 0.591137321 1.25765937 1.089176017 Up 9.36E-06 2.46E-05 CN5H6.4 1 - - - gi|47678373|emb|CAG30307.1|/1.06892e-42/cN5H6.4 [Homo sapiens] 9636 685 72 230 2.321695248 4.938417066 1.08887007 Up 3.80E-09 1.30E-08 ISG15 3 GO:0044421//extracellular region part;GO:0044444//cytoplasmic part GO:0005488//binding GO:0001818//negative regulation of cytokine production;GO:0006464//cellular protein modification process;GO:0007154//cell communication;GO:0019221//cytokine-mediated signaling pathway;GO:0051603//proteolysis involved in cellular protein catabolic process;GO:0051707//response to other organism "gi|340780633|pdb|3SDL|C/5.89359e-76/Chain C, Crystal Structure Of Human Isg15 In Complex With Ns1 N-Terminal Region From Influenza B Virus, Northeast Structural Genomics Consortium Target Ids Hx6481, Hr2873, And Or2" 100131205 566 31 99 1.209785988 2.57258222 1.08846533 Up 0.000123289 0.000289646 RPL21P28 1 GO:0015934//large ribosomal subunit GO:0003676//nucleic acid binding;GO:0005198//structural molecule activity GO:0006412//translation;GO:0019080;GO:0031016//pancreas development gi|119613805|gb|EAW93399.1|/1.0333e-89/hCG1782414 [Homo sapiens] 29906 2627 26 83 0.218613291 0.464695557 1.087904734 Up 0.000454366 0.000998044 ST8SIA5 4 GO:0031228//intrinsic to Golgi membrane GO:0008373//sialyltransferase activity GO:0006464//cellular protein modification process;GO:0006687//glycosphingolipid metabolic process "gi|28373101|ref|NP_037437.2|/0/alpha-2,8-sialyltransferase 8E [Homo sapiens]" 59286 537 3850 12286 158.3615454 336.5012839 1.087389958 Up 0 0 UBL5 3 GO:0044424//intracellular part - - "gi|40889756|pdb|1UH6|A/1.48101e-37/Chain A, Solution Structure Of The Murine Ubiquitin-Like 5 Protein From Riken Cdna 0610031k06//gi|40889756|pdb|1UH6|A/4.64071e-38/Chain A, Solution Structure Of The Murine Ubiquitin-Like 5 Protein From Riken Cdna 0610031k06" 340156 5760 43 137 0.164895673 0.349823181 1.085072349 Up 6.19E-06 1.65E-05 MYLK4 3 - GO:0004672//protein kinase activity;GO:0032559 GO:0006464//cellular protein modification process gi|167466233|ref|NP_001012418.2|/0/myosin light chain kinase family member 4 [Homo sapiens] 100125288 1997 140 446 1.548507304 3.284787612 1.084921903 Up 2.38E-16 1.19E-15 ZGLP1 1 GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0003677//DNA binding;GO:0046914//transition metal ion binding GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0007281//germ cell development;GO:0048232//male gamete generation gi|157266269|ref|NP_001096637.1|/2.90968e-163/GATA-type zinc finger protein 1 [Homo sapiens] 387066 524 4110 13064 173.250231 366.6868916 1.081691417 Up 0 0 SNHG5 2 - - - gi|119569006|gb|EAW48621.1|/3.51299e-11/hCG2031039 [Homo sapiens] 157869 3804 80 254 0.46452893 0.982072859 1.080061612 Up 7.51E-10 2.68E-09 SBSPON 3 GO:0044421//extracellular region part GO:0001871;GO:0004888//transmembrane signaling receptor activity GO:0002376//immune system process;GO:0023052//signaling gi|15146045|gb|AAK83466.1|/1.64733e-168/RPE-spondin [Homo sapiens] 348801 2233 229 726 2.265218223 4.781876967 1.07792697 Up 2.02E-25 1.42E-24 LNP1 1 - - - gi|146260273|ref|NP_001078920.1|/1.24868e-85/leukemia NUP98 fusion partner 1 [Homo sapiens] 257019 5306 77 244 0.320543347 0.676352471 1.077255817 Up 1.76E-09 6.14E-09 FRMD3 1 GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0043232 GO:0005515//protein binding - gi|117500790|ref|NP_777598.3|/0/FERM domain-containing protein 3 isoform 1 [Homo sapiens]//gi|350276212|ref|NP_001231888.1|/0/FERM domain-containing protein 3 isoform 2 [Homo sapiens]//gi|350276216|ref|NP_001231889.1|/0/FERM domain-containing protein 3 isoform 3 [Homo sapiens]//gi|350276218|ref|NP_001231890.1|/6.04776e-154/FERM domain-containing protein 3 isoform 4 [Homo sapiens]//gi|350276220|ref|NP_001231891.1|/3.50562e-93/FERM domain-containing protein 3 isoform 5 [Homo sapiens] 2785 962 34 107 0.780669357 1.635909242 1.067309166 Up 8.41E-05 0.000201838 GNG3 4 GO:0031234//extrinsic to internal side of plasma membrane GO:0017111//nucleoside-triphosphatase activity;GO:0031701//angiotensin receptor binding;GO:0060089 GO:0000165//MAPK cascade;GO:0007166//cell surface receptor signaling pathway;GO:0007267//cell-cell signaling;GO:0009207;GO:0015980//energy derivation by oxidation of organic compounds;GO:0033762//response to glucagon stimulus;GO:0051480//cytosolic calcium ion homeostasis gi|351699179|gb|EHB02098.1|/4.36851e-32/Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [Heterocephalus glaber] 653162 1440 85 265 1.303826252 2.706661105 1.053762634 Up 7.08E-10 2.53E-09 RPSAP9 1 GO:0005578//proteinaceous extracellular matrix;GO:0005626//insoluble fraction;GO:0015935//small ribosomal subunit;GO:0016020//membrane;GO:0030684//preribosome;GO:0043231//intracellular membrane-bounded organelle;GO:0044297//cell body GO:0004888//transmembrane signaling receptor activity;GO:0005198//structural molecule activity;GO:0005515//protein binding;GO:0043021//ribonucleoprotein complex binding "GO:0000462//maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006412//translation;GO:0007155//cell adhesion;GO:0019080;GO:0022618//ribonucleoprotein complex assembly;GO:0023052//signaling;GO:0030154//cell differentiation;GO:0031016//pancreas development" gi|44890755|gb|AAH66941.1|/2.06121e-149/Ribosomal protein SA [Homo sapiens] 100507634 2048 60 185 0.647119647 1.328593968 1.037795885 Up 3.82E-07 1.13E-06 LOC100507634 1 - - - gi|119627061|gb|EAX06656.1|/1.68526e-65/hCG2038638 [Homo sapiens] 255043 1751 110 339 1.387617686 2.847502096 1.03708677 Up 5.61E-12 2.26E-11 TMEM86B 4 GO:0031224//intrinsic to membrane - - gi|281427107|ref|NP_776165.3|/2.4218e-118/lysoplasmalogenase [Homo sapiens] 84698 2155 38 117 0.389492958 0.798526048 1.035742227 Up 5.90E-05 0.000144089 CAPS2 3 - GO:0046872//metal ion binding - gi|166795238|ref|NP_115995.2|/0/calcyphosin-2 [Homo sapiens] 6168 434 24329 74857 1238.220005 2536.840655 1.03476523 Up 0 0 RPL37A 4 GO:0030529//ribonucleoprotein complex;GO:0044444//cytoplasmic part GO:0005198//structural molecule activity;GO:0043169//cation binding GO:0006412//translation;GO:0019080;GO:0031016//pancreas development gi|4506643|ref|NP_000989.1|/9.30139e-48/60S ribosomal protein L37a [Homo sapiens] 171220 1122 118 363 2.323017267 4.758436393 1.034487709 Up 1.11E-12 4.66E-12 DSTNP2 2 GO:0015629//actin cytoskeleton GO:0008092//cytoskeletal protein binding GO:0030042//actin filament depolymerization "gi|119609124|gb|EAW88718.1|/5.26068e-75/hCG1640728, isoform CRA_b [Homo sapiens]" 54429 1150 40 122 0.768290456 1.560315744 1.022114263 Up 4.92E-05 0.000120916 TAS2R5 2 GO:0031224//intrinsic to membrane GO:0004930//G-protein coupled receptor activity GO:0007166//cell surface receptor signaling pathway;GO:0007606//sensory perception of chemical stimulus;GO:0007610//behavior gi|9507173|ref|NP_061853.1|/1.36158e-158/taste receptor type 2 member 5 [Homo sapiens] 257106 4425 63 192 0.314478212 0.638173041 1.020987598 Up 3.29E-07 9.81E-07 ARHGAP30 1 GO:0044444//cytoplasmic part GO:0008047//enzyme activator activity GO:0009966//regulation of signal transduction;GO:0035556//intracellular signal transduction gi|47077657|dbj|BAD18709.1|/0/FLJ00267 protein [Homo sapiens]//gi|71040096|ref|NP_859071.2|/0/rho GTPase-activating protein 30 isoform 2 [Homo sapiens] 286527 683 448 1359 14.48840568 29.26504885 1.014279839 Up 5.18E-42 5.63E-41 TMSB15B 2 - - GO:0007010//cytoskeleton organization gi|11496273|ref|NP_068832.1|/1.80774e-08/thymosin beta-15A [Homo sapiens] 9398 3557 258 782 1.602135074 3.233503893 1.013102562 Up 8.15E-25 5.62E-24 CD101 1 GO:0031224//intrinsic to membrane "GO:0016810//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds" GO:0007165//signal transduction "gi|119577068|gb|EAW56664.1|/0/immunoglobulin superfamily, member 2, isoform CRA_a [Homo sapiens]//gi|368711318|ref|NP_001243040.1|/0/immunoglobulin superfamily member 2 isoform 2 precursor [Homo sapiens] " 100289635 6202 453 1372 1.613354213 3.253665106 1.012002547 Up 3.00E-42 3.28E-41 ZNF605 1 GO:0005622//intracellular GO:0046872//metal ion binding - gi|257900460|ref|NP_001158187.1|/0/zinc finger protein 605 isoform 2 [Homo sapiens]//gi|34222391|ref|NP_899061.1|/0/zinc finger protein 605 isoform 1 [Homo sapiens] 84222 1978 35 106 0.390845436 0.788188471 1.011942458 Up 0.000178374 0.000412496 TMEM191A 1 GO:0031224//intrinsic to membrane - - gi|74717969|sp|Q9H0A3.1|T191A_HUMAN/2.17411e-86/RecName: Full=Transmembrane protein 191A 100463486 1290 1100 3326 18.83502766 37.92128408 1.009589665 Up 1.55E-99 4.14E-98 MTRNR2L8 1 - - - gi|345543|pir||JC1348/1.97832e-15/hypothetical 18K protein - goldfish mitochondrion 65266 4194 236 713 1.242930555 2.50041217 1.008420237 Up 1.33E-22 8.44E-22 WNK4 4 GO:0043296//apical junction complex;GO:0044424//intracellular part GO:0004672//protein kinase activity;GO:0032559 GO:0006464//cellular protein modification process;GO:0006796//phosphate-containing compound metabolic process;GO:0015698//inorganic anion transport;GO:0030320//cellular monovalent inorganic anion homeostasis;GO:0033036;GO:0035556//intracellular signal transduction gi|34365793|ref|NP_115763.2|/0/serine/threonine-protein kinase WNK4 [Homo sapiens] 89932 5849 52 157 0.196374463 0.394792171 1.007486051 Up 5.09E-06 1.37E-05 PAPLN 3 - - - gi|145309328|ref|NP_775733.3|/0/papilin precursor [Homo sapiens] 100507062 2555 141 425 1.218965729 2.446518622 1.005072699 Up 5.29E-14 2.37E-13 PSMD6-AS2 1 - - - - 100287898 1775 10 0 0.124441412 0.001 -6.959322859 Down 8.32E-05 0.000199856 TTC34 1 - - - gi|336455091|ref|NP_001229601.1|/0/tetratricopeptide repeat protein 34 [Homo sapiens] 1812 3373 12 0 0.078582925 0.001 -6.296143971 Down 1.33E-05 3.44E-05 DRD1 3 GO:0005626//insoluble fraction;GO:0016021//integral to membrane;GO:0030425//dendrite;GO:0031090//organelle membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0044297//cell body;GO:0044459//plasma membrane part "GO:0001588//dopamine neurotransmitter receptor activity, coupled via Gs" "GO:0001508//regulation of action potential;GO:0002209//behavioral defense response;GO:0006605//protein targeting;GO:0006813//potassium ion transport;GO:0007189//adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007200//phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007618//mating;GO:0007631//feeding behavior;GO:0007632//visual behavior;GO:0008344//adult locomotory behavior;GO:0010524//positive regulation of calcium ion transport into cytosol;GO:0014073;GO:0014075//response to amine stimulus;GO:0014821;GO:0015758//glucose transport;GO:0021544//subpallium development;GO:0021766//hippocampus development;GO:0021782//glial cell development;GO:0021830;GO:0032102;GO:0032225//regulation of synaptic transmission, dopaminergic;GO:0032868//response to insulin stimulus;GO:0033673//negative regulation of kinase activity;GO:0042069//regulation of catecholamine metabolic process;GO:0042754//negative regulation of circadian rhythm;GO:0046475//glycerophospholipid catabolic process;GO:0046958//nonassociative learning;GO:0048168//regulation of neuronal synaptic plasticity;GO:0048871//multicellular organismal homeostasis;GO:0050806//positive regulation of synaptic transmission;GO:0051937" "gi|119581780|gb|EAW61376.1|/0/dopamine receptor D1, isoform CRA_a [Homo sapiens]" 25812 3995 10 0 0.055289989 0.001 -5.78894638 Down 8.32E-05 0.000199831 POM121L1P 1 - - - gi|194380164|dbj|BAG63849.1|/0/unnamed protein product [Homo sapiens] 100506314 1743 12 1 0.152071261 0.008438264 -4.17165748 Down 0.00011706 0.000276169 LOC100506314 1 - - - "gi|119616698|gb|EAW96292.1|/4.63229e-45/hCG1774691, isoform CRA_b [Homo sapiens]" 3269 4578 17 2 0.082023146 0.006425467 -3.674157821 Down 9.96E-06 2.61E-05 HRH1 1 GO:0005626//insoluble fraction;GO:0016021//integral to membrane;GO:0031981//nuclear lumen GO:0008227//G-protein coupled amine receptor activity;GO:0043176//amine binding GO:0006694//steroid biosynthetic process;GO:0006952//defense response;GO:0007186//G-protein coupled receptor signaling pathway;GO:0007267//cell-cell signaling;GO:0009628//response to abiotic stimulus;GO:0019229//regulation of vasoconstriction;GO:0031328//positive regulation of cellular biosynthetic process gi|4504491|ref|NP_000852.1|/0/histamine H1 receptor [Homo sapiens] 137075 1972 14 2 0.156813848 0.014916729 -3.394049902 Down 0.000113115 0.000267127 CLDN23 2 GO:0031224//intrinsic to membrane;GO:0043296//apical junction complex GO:0005515//protein binding GO:0007043//cell-cell junction assembly;GO:0016337//cell-cell adhesion gi|124107616|ref|NP_919260.2|/3.64173e-142/claudin-23 [Homo sapiens] 130497 1911 23 4 0.265846187 0.030785755 -3.110256936 Down 1.64E-06 4.61E-06 OSR1 2 GO:0031981//nuclear lumen GO:0046914//transition metal ion binding "GO:0006351//transcription, DNA-dependent;GO:0006915//apoptotic process;GO:0007498//mesoderm development;GO:0008284//positive regulation of cell proliferation;GO:0010463//mesenchymal cell proliferation;GO:0030857//negative regulation of epithelial cell differentiation;GO:0042471//ear morphogenesis;GO:0045137//development of primary sexual characteristics;GO:0072012//glomerulus vasculature development;GO:0072075//metanephric mesenchyme development;GO:0072141//renal interstitial cell development;GO:0072165;GO:0072166//posterior mesonephric tubule development;GO:0072171" gi|384945338|gb|AFI36274.1|/5.77141e-145/protein odd-skipped-related 1 [Macaca mulatta] 2863 2821 25 5 0.195749297 0.026068583 -2.908623075 Down 1.33E-06 3.77E-06 GPR39 2 GO:0016021//integral to membrane GO:0004888//transmembrane signaling receptor activity;GO:0043169//cation binding GO:0007166//cell surface receptor signaling pathway gi|4504097|ref|NP_001499.1|/0/G-protein coupled receptor 39 [Homo sapiens] 677839 138 15 3 2.400907676 0.319736833 -2.908623075 Down 0.000200502 0.000460316 SNORA71C 2 - - - - 387097 1444 19 4 0.290636192 0.040742089 -2.834622493 Down 3.41E-05 8.51E-05 C6orf147 1 GO:0031224//intrinsic to membrane GO:0003676//nucleic acid binding - gi|353523794|ref|NP_001238803.1|/1.0265e-31/KH homology domain-containing protein 1 isoform 1 [Homo sapiens] 55511 3069 18 4 0.129550444 0.019169624 -2.756619981 Down 7.15E-05 0.000173021 SAGE1 2 - - - gi|145580597|ref|NP_061136.2|/0/sarcoma antigen 1 [Homo sapiens] 100505676 4372 17 4 0.085887914 0.013456445 -2.674157821 Down 0.00014885 0.000346704 LOC100505676 1 - - - "gi|119618124|gb|EAW97718.1|/2.98027e-28/5'-nucleotidase domain containing 3, isoform CRA_d [Homo sapiens]" 342125 3303 20 5 0.133747203 0.022264448 -2.58669498 Down 5.20E-05 0.000127624 TMC3 1 GO:0031224//intrinsic to membrane - - gi|122937502|ref|NP_001074001.1|/0/transmembrane channel-like protein 3 [Homo sapiens] 100505893 628 22 6 0.773795722 0.140521283 -2.461164098 Down 3.66E-05 9.12E-05 SLIT2-IT1 2 - - - gi|119613200|gb|EAW92794.1|/9.72648e-32/hCG2045574 [Homo sapiens] 145783 3017 21 6 0.15374722 0.029250038 -2.394049902 Down 7.33E-05 0.000177121 LOC145783 1 - - - gi|119597916|gb|EAW77510.1|/1.15962e-36/hCG1820887 [Homo sapiens] 5367 757 22 7 0.641933572 0.136004307 -2.238771676 Down 9.73E-05 0.000231455 PMCH 2 GO:0043231//intracellular membrane-bounded organelle;GO:0044421//extracellular region part GO:0005179//hormone activity;GO:0031776 "GO:0001963//synaptic transmission, dopaminergic;GO:0006950//response to stress;GO:0007186//G-protein coupled receptor signaling pathway;GO:0007589//body fluid secretion;GO:0007631//feeding behavior;GO:0008016//regulation of heart contraction;GO:0008217//regulation of blood pressure;GO:0033500//carbohydrate homeostasis;GO:0042320//regulation of circadian sleep/wake cycle, REM sleep;GO:0048167//regulation of synaptic plasticity;GO:0048232//male gamete generation;GO:0048869//cellular developmental process;GO:0051480//cytosolic calcium ion homeostasis" gi|71361684|ref|NP_002665.2|/1.97394e-89/pro-MCH preproprotein [Homo sapiens] 27199 2285 28 10 0.270666878 0.064367152 -2.072121807 Down 2.78E-05 6.98E-05 OXGR1 3 GO:0031224//intrinsic to membrane GO:0001608;GO:0001882//nucleoside binding;GO:0032559 GO:0035588 gi|52426789|ref|NP_543008.3|/0/2-oxoglutarate receptor 1 [Homo sapiens] 100506776 3516 36 13 0.226160587 0.054380724 -2.056180263 Down 2.20E-06 6.13E-06 LOC100506776 1 - - - "gi|119577128|gb|EAW56724.1|/5.94204e-25/GLI-Kruppel family member HKR1, isoform CRA_d [Homo sapiens]" 9940 5632 26 12 0.101970369 0.031337843 -1.702172197 Down 0.000416638 0.000920158 DLEC1 2 GO:0044424//intracellular part - GO:0008283//cell proliferation gi|90669194|ref|NP_031361.2|/0/deleted in lung and esophageal cancer protein 1 isoform DLEC1-N1 [Homo sapiens]//gi|90669228|ref|NP_031363.2|/0/deleted in lung and esophageal cancer protein 1 isoform DLEC1-S3 [Homo sapiens] 55220 2500 28 13 0.247389527 0.07648105 -1.693610184 Down 0.000262054 0.00059235 KLHDC8A 1 - - - gi|8922640|ref|NP_060673.1|/0/kelch domain-containing protein 8A [Homo sapiens] 221662 2467 30 14 0.268605804 0.083465959 -1.686230653 Down 0.000165085 0.000382973 RBM24 1 GO:0043231//intracellular membrane-bounded organelle GO:0003723//RNA binding;GO:0003729//mRNA binding GO:0009987//cellular process;GO:0014902//myotube differentiation;GO:0016071//mRNA metabolic process gi|221139802|ref|NP_001137414.1|/5.51107e-90/RNA-binding protein 24 isoform 1 [Homo sapiens]//gi|23308561|ref|NP_694565.1|/1.61457e-62/RNA-binding protein 24 isoform 2 [Homo sapiens]//gi|291409234|ref|XP_002720915.1|/5.798e-60/PREDICTED: RNA binding motif protein 24 [Oryctolagus cuniculus] 57571 3983 32 16 0.177461014 0.059082679 -1.58669498 Down 0.000196519 0.000451879 CARNS1 1 - - - gi|119595023|gb|EAW74617.1|/0/hCG21065 [Homo sapiens] //gi|261245046|ref|NP_001159694.1|/0/carnosine synthase 1 isoform 1 [Homo sapiens] 57537 6061 32 16 0.116618911 0.038826317 -1.58669498 Down 0.000196519 0.000451933 SORCS2 2 GO:0031224//intrinsic to membrane GO:0008528//G-protein coupled peptide receptor activity GO:0007186//G-protein coupled receptor signaling pathway gi|170014689|ref|NP_065828.2|/0/VPS10 domain-containing receptor SorCS2 precursor [Homo sapiens] 5744 1881 52 27 0.610629576 0.2111181 -1.532247196 Down 3.69E-06 1.01E-05 PTHLH 1 GO:0043231//intracellular membrane-bounded organelle;GO:0044421//extracellular region part GO:0005102//receptor binding GO:0001649//osteoblast differentiation;GO:0002062//chondrocyte differentiation;GO:0006171//cAMP biosynthetic process;GO:0007154//cell communication;GO:0007188//adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0008283//cell proliferation;GO:0022414//reproductive process;GO:0043392//negative regulation of DNA binding;GO:0048646//anatomical structure formation involved in morphogenesis;GO:0048875//chemical homeostasis within a tissue;GO:0051604//protein maturation;GO:0060560//developmental growth involved in morphogenesis gi|130499270|ref|NP_001076188.1|/4.36862e-65/parathyroid hormone-related protein precursor [Oryctolagus cuniculus]//gi|130499270|ref|NP_001076188.1|/4.423e-65/parathyroid hormone-related protein precursor [Oryctolagus cuniculus]//gi|39995091|ref|NP_945316.1|/1.24226e-65/parathyroid hormone-related protein isoform 1 preproprotein [Homo sapiens]//gi|39995091|ref|NP_945316.1|/1.26694e-65/parathyroid hormone-related protein isoform 1 preproprotein [Homo sapiens] 407975 5018 1656 861 7.289419814 2.523614388 -1.53031251 Down 2.37E-150 9.61E-149 MIR17HG 1 - - - gi|119629331|gb|EAX08926.1|/5.16333e-35/hCG2038628 [Homo sapiens]//gi|47076874|dbj|BAD18387.1|/7.18381e-34/C13orf25 v_2 [Homo sapiens] 54345 1718 43 24 0.552851616 0.205465345 -1.427997234 Down 6.59E-05 0.000160058 SOX18 2 GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0043565//sequence-specific DNA binding GO:0001885//endothelial cell development;GO:0001945//lymph vessel development;GO:0003348;GO:0008544//epidermis development;GO:0022404;GO:0043009//chordate embryonic development;GO:0043542//endothelial cell migration;GO:0048646//anatomical structure formation involved in morphogenesis gi|8924248|ref|NP_060889.1|/3.52147e-122/transcription factor SOX-18 [Homo sapiens] 158326 10086 57 33 0.12483006 0.0481222 -1.375190874 Down 8.04E-06 2.12E-05 FREM1 1 GO:0005578//proteinaceous extracellular matrix;GO:0031224//intrinsic to membrane GO:0030246//carbohydrate binding;GO:0043169//cation binding GO:0031589//cell-substrate adhesion;GO:0032501//multicellular organismal process gi|122056683|ref|NP_659403.4|/0/FRAS1-related extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]//gi|295293182|ref|NP_001171175.1|/0/FRAS1-related extracellular matrix protein 1 isoform 2 [Homo sapiens] 221981 10607 103 61 0.214490442 0.084583912 -1.342458169 Down 3.86E-09 1.32E-08 THSD7A 2 GO:0031224//intrinsic to membrane - - gi|150170672|ref|NP_056019.1|/0/thrombospondin type-1 domain-containing protein 7A precursor [Homo sapiens] 29995 1754 404 246 5.087624658 2.062794754 -1.302391957 Down 4.66E-30 3.77E-29 LMCD1 2 GO:0043231//intracellular membrane-bounded organelle;GO:0044421//extracellular region part GO:0003712//transcription cofactor activity;GO:0046914//transition metal ion binding GO:0003300//cardiac muscle hypertrophy;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0050850//positive regulation of calcium-mediated signaling gi|7657309|ref|NP_055398.1|/0/LIM and cysteine-rich domains protein 1 [Homo sapiens] 2194 8481 48282 29654 125.7481128 51.42647067 -1.289953696 Down 0 0 FASN 4 GO:0000267//cell fraction;GO:0016020//membrane;GO:0048770 GO:0016297//acyl-[acyl-carrier-protein] hydrolase activity;GO:0019842//vitamin binding;GO:0022892;GO:0042802//identical protein binding;GO:0046914//transition metal ion binding;GO:0050661//NADP binding GO:0006575//cellular modified amino acid metabolic process;GO:0006631//fatty acid metabolic process;GO:0006641//triglyceride metabolic process;GO:0006766//vitamin metabolic process;GO:0009893//positive regulation of metabolic process;GO:0015980//energy derivation by oxidation of organic compounds;GO:0035336//long-chain fatty-acyl-CoA metabolic process gi|41872631|ref|NP_004095.4|/0/fatty acid synthase [Homo sapiens] 5743 4507 78 49 0.382270102 0.159903888 -1.257387354 Down 1.12E-06 3.21E-06 PTGS2 2 GO:0031090//organelle membrane;GO:0032991//macromolecular complex;GO:0042598;GO:0042995//cell projection;GO:0044432//endoplasmic reticulum part;GO:0044459//plasma membrane part "GO:0005506//iron ion binding;GO:0005515//protein binding;GO:0016209//antioxidant activity;GO:0016701//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0016705//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" "GO:0001503//ossification;GO:0001516//prostaglandin biosynthetic process;GO:0001660//fever generation;GO:0001819//positive regulation of cytokine production;GO:0001963//synaptic transmission, dopaminergic;GO:0002042//cell migration involved in sprouting angiogenesis;GO:0002237//response to molecule of bacterial origin;GO:0003006//developmental process involved in reproduction;GO:0006915//apoptotic process;GO:0006939//smooth muscle contraction;GO:0007049//cell cycle;GO:0007292//female gamete generation;GO:0007611//learning or memory;GO:0008284//positive regulation of cell proliferation;GO:0009746;GO:0010038//response to metal ion;GO:0019229//regulation of vasoconstriction;GO:0022405//hair cycle process;GO:0031328//positive regulation of cellular biosynthetic process;GO:0031347//regulation of defense response;GO:0031960//response to corticosteroid stimulus;GO:0033273//response to vitamin;GO:0043271//negative regulation of ion transport;GO:0043627//response to estrogen stimulus;GO:0045600//positive regulation of fat cell differentiation;GO:0048167//regulation of synaptic plasticity;GO:0050806//positive regulation of synaptic transmission" gi|4506265|ref|NP_000954.1|/0/prostaglandin G/H synthase 2 precursor [Homo sapiens] 4627 7505 30327 19161 89.25694993 37.55069458 -1.249124914 Down 0 0 MYH9 4 GO:0005887//integral to plasma membrane;GO:0005911//cell-cell junction;GO:0015630//microtubule cytoskeleton;GO:0031252//cell leading edge;GO:0031254//trailing edge;GO:0032155;GO:0032432//actin filament bundle;GO:0032991//macromolecular complex;GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part;GO:0045202//synapse "GO:0003774//motor activity;GO:0003779//actin binding;GO:0032559;GO:0042623//ATPase activity, coupled;GO:0042802//identical protein binding" GO:0000768//syncytium formation by plasma membrane fusion;GO:0000902//cell morphogenesis;GO:0001767;GO:0002573//myeloid leukocyte differentiation;GO:0006810//transport;GO:0006935//chemotaxis;GO:0007051//spindle organization;GO:0007127//meiosis I;GO:0007155//cell adhesion;GO:0007166//cell surface receptor signaling pathway;GO:0009207;GO:0030030//cell projection organization;GO:0030036//actin cytoskeleton organization;GO:0033619//membrane protein proteolysis;GO:0043009//chordate embryonic development;GO:0043542//endothelial cell migration;GO:0065008 gi|12667788|ref|NP_002464.1|/0/myosin-9 [Homo sapiens] 9413 2423 129 82 1.175979047 0.497749622 -1.24037023 Down 5.90E-10 2.12E-09 FAM189A2 1 GO:0031224//intrinsic to membrane - - "gi|119582886|gb|EAW62482.1|/0/chromosome 9 open reading frame 61, isoform CRA_a [Homo sapiens]" 7092 7284 154 98 0.466996979 0.197882158 -1.238771676 Down 1.39E-11 5.50E-11 TLL1 1 - GO:0004175//endopeptidase activity;GO:0005515//protein binding;GO:0046914//transition metal ion binding GO:0019538//protein metabolic process;GO:0048731;GO:0048869//cellular developmental process gi|22547221|ref|NP_036596.3|/0/tolloid-like protein 1 isoform 1 precursor [Homo sapiens]//gi|325652110|ref|NP_001191689.1|/0/tolloid-like protein 1 isoform 2 precursor [Homo sapiens] 1778 14361 53632 34186 82.49024583 35.01177319 -1.236383406 Down 0 0 DYNC1H1 4 GO:0030286//dynein complex;GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part GO:0003774//motor activity;GO:0016887//ATPase activity;GO:0032559 GO:0000278//mitotic cell cycle;GO:0007017//microtubule-based process;GO:0022402//cell cycle process;GO:0022618//ribonucleoprotein complex assembly;GO:0051234//establishment of localization gi|71891782|dbj|BAA20783.3|/0/KIAA0325 protein [Homo sapiens] 94032 1360 83 53 1.348039045 0.573175293 -1.233813956 Down 7.53E-07 2.17E-06 CAMK2N2 2 GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part "GO:0004860//protein kinase inhibitor activity;GO:0016772//transferase activity, transferring phosphorus-containing groups;GO:0019900//kinase binding" GO:0001932//regulation of protein phosphorylation;GO:0033673//negative regulation of kinase activity;GO:0050804//regulation of synaptic transmission gi|15147234|ref|NP_150284.1|/3.9752e-30/calcium/calmodulin-dependent protein kinase II inhibitor 2 [Homo sapiens] 3431 2591 122 78 1.040053561 0.442769493 -1.232030098 Down 2.09E-09 7.27E-09 SP110 3 GO:0043231//intracellular membrane-bounded organelle GO:0003676//nucleic acid binding;GO:0046914//transition metal ion binding;GO:0060089 GO:0023052//signaling;GO:0051704 gi|190343006|ref|NP_536349.2|/0/sp110 nuclear body protein isoform c [Homo sapiens]//gi|190343008|ref|NP_004501.3|/0/sp110 nuclear body protein isoform b [Homo sapiens]//gi|190343010|ref|NP_004500.3|/0/sp110 nuclear body protein isoform a [Homo sapiens]//gi|297139787|ref|NP_001171944.1|/0/sp110 nuclear body protein isoform d [Homo sapiens] 79948 2405 81 52 0.743931975 0.318008526 -1.226105264 Down 1.16E-06 3.30E-06 LPPR3 2 GO:0016020//membrane GO:0016787//hydrolase activity GO:0008152//metabolic process gi|13376339|ref|NP_079164.1|/0/lipid phosphate phosphatase-related protein type 3 isoform 1 [Homo sapiens]//gi|392996998|ref|NP_001257295.1|/0/lipid phosphate phosphatase-related protein type 3 isoform 2 [Homo sapiens] 2334 13746 45 29 0.072310183 0.031029313 -1.220567081 Down 0.000302762 0.00068009 AFF2 1 GO:0016604//nuclear body GO:0003723//RNA binding GO:0006396//RNA processing;GO:0007417//central nervous system development;GO:0010468//regulation of gene expression gi|282165691|ref|NP_001162593.1|/0/AF4/FMR2 family member 2 isoform 2 [Homo sapiens]//gi|282165693|ref|NP_001162594.1|/0/AF4/FMR2 family member 2 isoform 3 [Homo sapiens]//gi|282165695|ref|NP_001162595.1|/0/AF4/FMR2 family member 2 isoform 4 [Homo sapiens]//gi|282165697|ref|NP_001162596.1|/0/AF4/FMR2 family member 2 isoform 5 [Homo sapiens]//gi|282165701|ref|NP_001164099.1|/0/AF4/FMR2 family member 2 isoform 6 [Homo sapiens] //gi|87162461|ref|NP_002016.2|/0/AF4/FMR2 family member 2 isoform 1 [Homo sapiens] 78990 3873 707 459 4.032136299 1.743073454 -1.209911041 Down 8.01E-46 9.39E-45 OTUB2 3 - GO:0005488//binding;GO:0008238//exopeptidase activity;GO:0019783//small conjugating protein-specific protease activity GO:0016579//protein deubiquitination;GO:0019752//carboxylic acid metabolic process gi|12962939|ref|NP_075601.1|/4.04789e-130/ubiquitin thioesterase OTUB2 [Homo sapiens] 441263 1782 46 30 0.57018189 0.247607648 -1.20336634 Down 0.000304142 0.000683109 DTX2P1-UPK3BP1-PMS2P11 1 - GO:0005488//binding - gi|1061426|gb|AAA97460.1|/8.1297e-146/hPMSR6 [Homo sapiens] 392255 3716 69 46 0.410144293 0.182067583 -1.17165748 Down 1.50E-05 3.87E-05 GDF6 2 GO:0044421//extracellular region part GO:0005102//receptor binding;GO:0042802//identical protein binding GO:0001934//positive regulation of protein phosphorylation;GO:0007178//transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0045597//positive regulation of cell differentiation gi|48475062|ref|NP_001001557.1|/0/growth/differentiation factor 6 precursor [Homo sapiens] 5328 2680 54 36 0.445063781 0.197568729 -1.17165748 Down 0.000128206 0.000300716 PLAU 1 GO:0016020//membrane;GO:0044421//extracellular region part GO:0004175//endopeptidase activity GO:0001952//regulation of cell-matrix adhesion;GO:0008283//cell proliferation;GO:0009966//regulation of signal transduction;GO:0014909//smooth muscle cell migration;GO:0019538//protein metabolic process;GO:0030195//negative regulation of blood coagulation;GO:0042221//response to chemical stimulus gi|222537759|ref|NP_001138503.1|/0/urokinase-type plasminogen activator isoform 2 [Homo sapiens]//gi|4505863|ref|NP_002649.1|/0/urokinase-type plasminogen activator isoform 1 preproprotein [Homo sapiens] 3727 1890 928 623 10.84549702 4.848157753 -1.161587622 Down 6.67E-56 9.57E-55 JUND 4 GO:0043229//intracellular organelle GO:0043565//sequence-specific DNA binding "GO:0006355//regulation of transcription, DNA-dependent" gi|102469037|ref|NP_005345.3|/1.24219e-99/transcription factor jun-D [Homo sapiens] 3371 8605 563 379 1.445176223 0.647796856 -1.157632054 Down 2.01E-34 1.82E-33 TNC 3 GO:0005578//proteinaceous extracellular matrix GO:0005515//protein binding GO:0002009//morphogenesis of an epithelium;GO:0006950//response to stress;GO:0008283//cell proliferation;GO:0010467//gene expression;GO:0023052//signaling;GO:0048610//cellular process involved in reproduction;GO:0048741//skeletal muscle fiber development gi|68533131|dbj|BAE06120.1|/0/TNC variant protein [Homo sapiens] 729171 3670 86 58 0.517601677 0.232440836 -1.154978739 Down 1.79E-06 5.02E-06 ANKRD20A8P 2 GO:0016020//membrane - - "gi|119631101|gb|EAX10696.1|/0/hCG2003116, isoform CRA_a [Homo sapiens]" 10811 1650 163 110 2.182061304 0.980526287 -1.15406342 Down 5.07E-11 1.95E-10 NOXA1 1 GO:0005887//integral to plasma membrane;GO:0044424//intracellular part GO:0008047//enzyme activator activity;GO:0017048//Rho GTPase binding GO:0019222//regulation of metabolic process;GO:0042743//hydrogen peroxide metabolic process gi|366039970|ref|NP_001242996.1|/0/NADPH oxidase activator 1 isoform 2 [Homo sapiens]//gi|366039972|ref|NP_001242997.1|/0/NADPH oxidase activator 1 isoform 3 [Homo sapiens]//gi|41393187|ref|NP_006638.1|/0/NADPH oxidase activator 1 isoform 1 [Homo sapiens] 5737 5431 117 79 0.475849203 0.213942856 -1.153278951 Down 2.65E-08 8.56E-08 PTGFR 1 GO:0016021//integral to membrane GO:0004955//prostaglandin receptor activity GO:0007166//cell surface receptor signaling pathway;GO:0022414//reproductive process gi|351698844|gb|EHB01763.1|/5.37838e-175/Prostaglandin F2-alpha receptor [Heterocephalus glaber]//gi|4506261|ref|NP_000950.1|/0/prostaglandin F2-alpha receptor isoform a precursor [Homo sapiens] 81788 3443 93 63 0.596635669 0.26912499 -1.148573867 Down 7.66E-07 2.21E-06 NUAK2 1 - GO:0004672//protein kinase activity;GO:0032559;GO:0046872//metal ion binding GO:0006464//cellular protein modification process;GO:0006796//phosphate-containing compound metabolic process;GO:0006915//apoptotic process;GO:0007010//cytoskeleton organization;GO:0009267//cellular response to starvation gi|194383252|dbj|BAG64597.1|/0/unnamed protein product [Homo sapiens] 100288123 1698 56 38 0.728473283 0.329151934 -1.146122388 Down 0.00012743 0.000298968 LOC100288123 1 - - - gi|119589858|gb|EAW69452.1|/6.04873e-42/hCG2045262 [Homo sapiens] 26512 7465 1606 1091 4.752028278 2.149539543 -1.144515771 Down 3.72E-93 9.12E-92 INTS6 1 "GO:0005856//cytoskeleton;GO:0016591//DNA-directed RNA polymerase II, holoenzyme" GO:0004872//receptor activity;GO:0005488//binding GO:0016073//snRNA metabolic process gi|11024694|ref|NP_036273.1|/0/integrator complex subunit 6 isoform a [Homo sapiens]//gi|90193624|ref|NP_001035027.1|/8.68226e-59/integrator complex subunit 6 isoform c [Homo sapiens] 55879 2000 79 54 0.872489849 0.397113146 -1.135588226 Down 6.32E-06 1.69E-05 GABRQ 2 GO:0034702//ion channel complex;GO:0044459//plasma membrane part GO:0005253//anion channel activity;GO:0015276//ligand-gated ion channel activity;GO:0016917//GABA receptor activity GO:0007186//G-protein coupled receptor signaling pathway;GO:0015698//inorganic anion transport gi|268838843|ref|NP_061028.2|/0/gamma-aminobutyric acid receptor subunit theta precursor [Homo sapiens] 728747 3517 54 37 0.339144422 0.154731899 -1.132129116 Down 0.000195095 0.00044893 ANKRD20A4 1 GO:0016020//membrane - - gi|149363679|ref|NP_001092275.1|/0/ankyrin repeat domain-containing protein 20A4 [Homo sapiens] 83714 2787 115 79 0.911431762 0.416908378 -1.128404282 Down 6.01E-08 1.89E-07 NRIP2 2 GO:0043231//intracellular membrane-bounded organelle GO:0004175//endopeptidase activity;GO:0005488//binding GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0019538//protein metabolic process gi|13899327|ref|NP_113662.1|/8.72995e-140/nuclear receptor-interacting protein 2 [Homo sapiens] 5799 4842 71 49 0.323889487 0.148840731 -1.121732255 Down 2.25E-05 5.71E-05 PTPRN2 2 GO:0005626//insoluble fraction;GO:0016021//integral to membrane;GO:0016023//cytoplasmic membrane-bounded vesicle;GO:0033267//axon part GO:0004725//protein tyrosine phosphatase activity;GO:0004871//signal transducer activity;GO:0005488//binding GO:0006464//cellular protein modification process;GO:0006796//phosphate-containing compound metabolic process;GO:0043087//regulation of GTPase activity gi|194097438|ref|NP_570857.2|/0/receptor-type tyrosine-protein phosphatase N2 isoform 2 precursor [Homo sapiens]//gi|194097440|ref|NP_002838.2|/0/receptor-type tyrosine-protein phosphatase N2 isoform 1 precursor [Homo sapiens]//gi|194097442|ref|NP_570858.2|/0/receptor-type tyrosine-protein phosphatase N2 isoform 3 precursor [Homo sapiens] 25822 2817 646 451 5.06534416 2.354725003 -1.105101711 Down 1.67E-36 1.60E-35 DNAJB5 2 GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part GO:0005515//protein binding GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0044267//cellular protein metabolic process gi|15082401|gb|AAH12115.1|/0/DNAJB5 protein [Homo sapiens] //gi|201862587|ref|NP_001128477.1|/0/dnaJ homolog subfamily B member 5 isoform 1 [Homo sapiens]//gi|330864767|ref|NP_001128476.2|/0/dnaJ homolog subfamily B member 5 isoform 2 [Homo sapiens] 6781 3897 229 161 1.297981086 0.607639462 -1.09498189 Down 8.78E-14 3.90E-13 STC1 2 GO:0044421//extracellular region part;GO:0044424//intracellular part;GO:0044459//plasma membrane part GO:0005102//receptor binding GO:0001666//response to hypoxia;GO:0003006//developmental process involved in reproduction;GO:0006875//cellular metal ion homeostasis;GO:0007154//cell communication;GO:0007165//signal transduction;GO:0007275//multicellular organismal development;GO:0030002//cellular anion homeostasis;GO:0033273//response to vitamin;GO:0051384//response to glucocorticoid stimulus;GO:0051591//response to cAMP gi|4507265|ref|NP_003146.1|/4.49627e-137/stanniocalcin-1 precursor [Homo sapiens] 55359 3022 88 62 0.643208092 0.301750313 -1.091930288 Down 3.93E-06 1.07E-05 STYK1 2 GO:0031224//intrinsic to membrane GO:0004713//protein tyrosine kinase activity;GO:0032559 GO:0006464//cellular protein modification process gi|222352145|ref|NP_060893.2|/0/tyrosine-protein kinase STYK1 [Homo sapiens] 161882 3241 194 137 1.322166004 0.621715989 -1.088575739 Down 8.38E-12 3.35E-11 ZFPM1 2 GO:0031981//nuclear lumen GO:0003712//transcription cofactor activity;GO:0005488//binding GO:0007599//hemostasis;GO:0048513//organ development gi|110556644|ref|NP_722520.2|/0/zinc finger protein ZFPM1 [Homo sapiens] 285513 6352 1279 908 4.447575636 2.102450886 -1.080947041 Down 4.53E-68 7.88E-67 GPRIN3 2 - - - gi|40789081|dbj|BAC23123.2|/0/KIAA2027 protein [Homo sapiens] 2637 1335 92 66 1.522193451 0.727131853 -1.065862816 Down 3.73E-06 1.02E-05 GBX2 2 GO:0043231//intracellular membrane-bounded organelle GO:0001071//nucleic acid binding transcription factor activity;GO:0003677//DNA binding "GO:0001525//angiogenesis;GO:0001667//ameboidal cell migration;GO:0006351//transcription, DNA-dependent;GO:0006935//chemotaxis;GO:0021546//rhombomere development;GO:0021924;GO:0022037//metencephalon development;GO:0030917//midbrain-hindbrain boundary development;GO:0042471//ear morphogenesis" gi|45593144|ref|NP_001476.2|/2.10858e-161/homeobox protein GBX-2 [Homo sapiens] 148113 4199 458 329 2.409255676 1.152392767 -1.063954994 Down 7.16E-25 4.95E-24 CILP2 2 GO:0031012//extracellular matrix GO:0005488//binding;GO:0008238//exopeptidase activity;GO:0016462//pyrophosphatase activity;GO:0016791//phosphatase activity - gi|145699139|ref|NP_694953.2|/0/cartilage intermediate layer protein 2 precursor [Homo sapiens] 776 7771 189 136 0.537215065 0.257402345 -1.061474563 Down 3.98E-11 1.54E-10 CACNA1D 1 GO:0034704//calcium channel complex GO:0005262//calcium channel activity GO:0006935//chemotaxis;GO:0015980//energy derivation by oxidation of organic compounds;GO:0030073//insulin secretion;GO:0032412//regulation of ion transmembrane transporter activity;GO:0070838//divalent metal ion transport gi|192807298|ref|NP_001122311.1|/0/voltage-dependent L-type calcium channel subunit alpha-1D isoform c [Homo sapiens]//gi|192807300|ref|NP_001122312.1|/0/voltage-dependent L-type calcium channel subunit alpha-1D isoform b [Homo sapiens]//gi|4502527|ref|NP_000711.1|/0/voltage-dependent L-type calcium channel subunit alpha-1D isoform a [Homo sapiens] 26093 2093 582 419 6.142102274 2.944389735 -1.060763889 Down 5.21E-31 4.31E-30 CCDC9 2 - - - gi|7661690|ref|NP_056418.1|/0/coiled-coil domain-containing protein 9 [Homo sapiens] 23130 6378 2682 1932 9.288328059 4.455260552 -1.059909123 Down 3.43E-136 1.25E-134 ATG2A 2 - GO:0005488//binding - gi|2662089|dbj|BAA23700.1|/0/KIAA0404 [Homo sapiens] 84467 8967 54 39 0.133017836 0.063968761 -1.056180263 Down 0.000431458 0.000950465 FBN3 3 GO:0031012//extracellular matrix GO:0005198//structural molecule activity;GO:0046872//metal ion binding - gi|73490266|dbj|BAB47408.2|/0/fibrillin3 [Homo sapiens] 10514 4585 9456 6848 45.55451329 21.96721051 -1.052242313 Down 0 0 MYBBP1A 3 GO:0031074//nucleocytoplasmic shuttling complex;GO:0031981//nuclear lumen GO:0003676//nucleic acid binding;GO:0005515//protein binding;GO:0034061 "GO:0006351//transcription, DNA-dependent;GO:0051169//nuclear transport" gi|157694492|ref|NP_055335.2|/0/myb-binding protein 1A isoform 2 [Homo sapiens]//gi|157694494|ref|NP_001099008.1|/0/myb-binding protein 1A isoform 1 [Homo sapiens] 6517 3159 109 79 0.762149483 0.367813754 -1.051098556 Down 6.46E-07 1.88E-06 SLC2A4 2 GO:0005770//late endosome;GO:0005798//Golgi-associated vesicle;GO:0005886//plasma membrane;GO:0009986//cell surface;GO:0012505//endomembrane system;GO:0016021//integral to membrane;GO:0030135//coated vesicle;GO:0030141//secretory granule;GO:0042598 GO:0005355//glucose transmembrane transporter activity;GO:0005488//binding GO:0010033//response to organic substance;GO:0015758//glucose transport;GO:0033500//carbohydrate homeostasis;GO:0044238//primary metabolic process;GO:0045444//fat cell differentiation "gi|4507011|ref|NP_001033.1|/0/solute carrier family 2, facilitated glucose transporter member 4 [Homo sapiens]" 8613 3324 1388 1007 9.223414759 4.455730917 -1.049638864 Down 2.66E-70 4.81E-69 PPAP2B 4 GO:0031090//organelle membrane;GO:0031224//intrinsic to membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0070161 GO:0005102//receptor binding;GO:0016791//phosphatase activity GO:0001934//positive regulation of protein phosphorylation;GO:0001944//vasculature development;GO:0006643//membrane lipid metabolic process;GO:0007276//gamete generation;GO:0007369//gastrulation;GO:0016337//cell-cell adhesion;GO:0019637//organophosphate metabolic process;GO:0031647//regulation of protein stability;GO:0043388//positive regulation of DNA binding;GO:0060070//canonical Wnt receptor signaling pathway gi|29171740|ref|NP_003704.3|/2.18986e-169/lipid phosphate phosphohydrolase 3 [Homo sapiens] 5091 4192 1865 1354 9.826997592 4.750593724 -1.048642871 Down 1.16E-93 2.86E-92 PC 1 GO:0000267//cell fraction;GO:0019866//organelle inner membrane;GO:0044429//mitochondrial part "GO:0016879//ligase activity, forming carbon-nitrogen bonds;GO:0016885;GO:0019842//vitamin binding;GO:0032559;GO:0043169//cation binding" GO:0006006//glucose metabolic process;GO:0006629//lipid metabolic process;GO:0032787//monocarboxylic acid metabolic process;GO:0043648//dicarboxylic acid metabolic process "gi|106049292|ref|NP_071504.2|/0/pyruvate carboxylase, mitochondrial precursor [Homo sapiens]" 83987 3334 2275 1658 15.07228484 7.314243779 -1.043117518 Down 7.56E-113 2.28E-111 CCDC8 4 GO:0016020//membrane - - gi|199559779|ref|NP_114429.2|/0/coiled-coil domain-containing protein 8 [Homo sapiens] 999 4815 321 234 1.472556708 0.714776172 -1.042759747 Down 2.26E-17 1.18E-16 CDH1 3 GO:0005856//cytoskeleton;GO:0005911//cell-cell junction;GO:0005924//cell-substrate adherens junction;GO:0016234//inclusion body;GO:0019897//extrinsic to plasma membrane;GO:0031224//intrinsic to membrane;GO:0044444//cytoplasmic part GO:0019902//phosphatase binding;GO:0046872//metal ion binding GO:0001825//blastocyst formation;GO:0002682//regulation of immune system process;GO:0007162//negative regulation of cell adhesion;GO:0010226//response to lithium ion;GO:0016337//cell-cell adhesion;GO:0021536//diencephalon development;GO:0030030//cell projection organization;GO:0042307//positive regulation of protein import into nucleus;GO:0042981//regulation of apoptotic process;GO:0043170;GO:0045216//cell-cell junction organization;GO:0051259//protein oligomerization;GO:0060605;GO:0060688//regulation of morphogenesis of a branching structure;GO:0071310//cellular response to organic substance gi|4757960|ref|NP_004351.1|/0/cadherin-1 preproprotein [Homo sapiens] 5097 4779 292 213 1.349612551 0.655530757 -1.041809918 Down 6.38E-16 3.14E-15 PCDH1 3 GO:0016021//integral to membrane;GO:0030054//cell junction GO:0046872//metal ion binding GO:0007154//cell communication;GO:0016337//cell-cell adhesion;GO:0048731 gi|27754771|ref|NP_002578.2|/0/protocadherin-1 isoform 1 precursor [Homo sapiens]//gi|27754773|ref|NP_115796.2|/0/protocadherin-1 isoform 2 precursor [Homo sapiens] 89837 1162 74 54 1.406659162 0.683499391 -1.041260843 Down 4.69E-05 0.00011545 ULK4P3 1 - - - gi|223590224|sp|Q0P5Q8.3|FAM7A_HUMAN/9.62988e-27/RecName: Full=Protein FAM7A 376497 3562 231 169 1.432456202 0.697819803 -1.037564585 Down 7.80E-13 3.30E-12 SLC27A1 1 GO:0019866//organelle inner membrane;GO:0031224//intrinsic to membrane;GO:0042598;GO:0043231//intracellular membrane-bounded organelle;GO:0044459//plasma membrane part GO:0005319//lipid transporter activity;GO:0015645//fatty acid ligase activity;GO:0042802//identical protein binding GO:0006655//phosphatidylglycerol biosynthetic process;GO:0006658//phosphatidylserine metabolic process;GO:0006950//response to stress;GO:0015908//fatty acid transport;GO:0019221//cytokine-mediated signaling pathway;GO:0031649//heat generation;GO:0032787//monocarboxylic acid metabolic process;GO:0043434//response to peptide hormone stimulus;GO:0045860//positive regulation of protein kinase activity;GO:0046335//ethanolamine biosynthetic process;GO:0046394;GO:0046470//phosphatidylcholine metabolic process gi|38524616|ref|NP_940982.1|/0/long-chain fatty acid transport protein 1 [Homo sapiens] 388815 3475 75 55 0.476726992 0.232786816 -1.034153957 Down 4.60E-05 0.000113461 LINC00478 1 - - - "gi|119630444|gb|EAX10039.1|/5.86081e-56/chromosome 21 open reading frame 34, isoform CRA_c [Homo sapiens]//gi|120659960|gb|AAI30607.1|/1.773e-54/Chromosome 21 open reading frame 34 [Homo sapiens]" 54809 6855 128 94 0.412444767 0.201683744 -1.032106128 Down 1.09E-07 3.35E-07 SAMD9 3 GO:0044424//intracellular part - - gi|24899174|dbj|BAC23101.1|/0/KIAA2004 protein [Homo sapiens] 4647 7465 290 213 0.858087298 0.419662624 -1.031894449 Down 1.35E-15 6.51E-15 MYO7A 1 GO:0005764//lysosome;GO:0005902//microvillus;GO:0015629//actin cytoskeleton;GO:0031513//nonmotile primary cilium;GO:0044459//plasma membrane part;GO:0048770 GO:0003774//motor activity;GO:0008092//cytoskeletal protein binding;GO:0032559 GO:0001754//eye photoreceptor cell differentiation;GO:0006897//endocytosis;GO:0006906//vesicle fusion;GO:0007033//vacuole organization;GO:0030029//actin filament-based process;GO:0042471//ear morphogenesis;GO:0050953//sensory perception of light stimulus;GO:0050954//sensory perception of mechanical stimulus;GO:0051648//vesicle localization;GO:0060122//inner ear receptor stereocilium organization gi|189083798|ref|NP_000251.3|/0/unconventional myosin-VIIa isoform 1 [Homo sapiens]//gi|189083802|ref|NP_001120652.1|/0/unconventional myosin-VIIa isoform 2 [Homo sapiens] //gi|256355179|ref|NP_001120651.2|/0/unconventional myosin-VIIa isoform 3 [Homo sapiens] 79784 6930 2211 1627 7.047235674 3.453065518 -1.029179754 Down 2.42E-107 6.97E-106 MYH14 1 - GO:0000166//nucleotide binding;GO:0005515//protein binding GO:0006935//chemotaxis "gi|119592244|gb|EAW71838.1|/0/myosin, heavy polypeptide 14, isoform CRA_a [Homo sapiens]//gi|119592249|gb|EAW71843.1|/0/myosin, heavy polypeptide 14, isoform CRA_f [Homo sapiens]//gi|224831241|ref|NP_001139281.1|/0/myosin-14 isoform 3 [Homo sapiens]" 646024 1891 191 141 2.23102854 1.096675355 -1.024572455 Down 1.14E-10 4.26E-10 RAET1K 1 GO:0031224//intrinsic to membrane;GO:0042611;GO:0043231//intracellular membrane-bounded organelle GO:0004888//transmembrane signaling receptor activity GO:0002682//regulation of immune system process;GO:0046649//lymphocyte activation gi|119568160|gb|EAW47775.1|/5.43999e-63/hCG1735795 [Homo sapiens] 2019 2962 261 193 1.946340146 0.958346928 -1.022143939 Down 5.44E-14 2.44E-13 EN1 3 - GO:0003677//DNA binding GO:0003002//regionalization;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0007420//brain development;GO:0030326//embryonic limb morphogenesis;GO:0048468//cell development "gi|119615611|gb|EAW95205.1|/1.89011e-116/engrailed homolog 1, isoform CRA_a [Homo sapiens]" 54718 2483 300 222 2.668749571 1.315003035 -1.021097804 Down 7.88E-16 3.87E-15 BTN2A3P 1 GO:0016021//integral to membrane - GO:0044238//primary metabolic process gi|16552389|dbj|BAB71298.1|/1.96535e-103/unnamed protein product [Homo sapiens] 84182 2750 66 49 0.530120415 0.262067935 -1.016379255 Down 0.000164038 0.000380685 FAM188B 2 - - - gi|93102405|ref|NP_115598.2|/0/protein FAM188B [Homo sapiens] 55356 4729 291 217 1.359211256 0.674902319 -1.01001909 Down 3.77E-15 1.78E-14 SLC22A15 2 GO:0031224//intrinsic to membrane GO:0005215//transporter activity GO:0006810//transport gi|166197673|ref|NP_060890.2|/0/solute carrier family 22 member 15 [Homo sapiens] 3913 5817 4989 3723 18.94426358 9.413355768 -1.008980033 Down 6.48E-232 4.25E-230 LAMB2 3 GO:0043256//laminin complex - GO:0048676 gi|119703755|ref|NP_002283.3|/0/laminin subunit beta-2 precursor [Homo sapiens] 23345 27748 2685 2011 2.137351211 1.065935399 -1.003703986 Down 1.11E-124 3.72E-123 SYNE1 3 GO:0030016//myofibril;GO:0031224//intrinsic to membrane;GO:0031965//nuclear membrane;GO:0031981//nuclear lumen;GO:0034992//microtubule organizing center attachment site GO:0008092//cytoskeletal protein binding GO:0007010//cytoskeleton organization;GO:0030154//cell differentiation;GO:0043578//nuclear matrix organization;GO:0051647//nucleus localization gi|23097308|ref|NP_149062.1|/0/nesprin-1 isoform 2 [Homo sapiens]//gi|330688408|ref|NP_892006.3|/0/nesprin-1 isoform 1 [Homo sapiens] 140738 1687 84 63 1.099834886 0.549257464 -1.001732479 Down 2.68E-05 6.75E-05 TMEM37 2 GO:0031224//intrinsic to membrane GO:0005261//cation channel activity GO:0034220//ion transmembrane transport gi|116325983|ref|NP_899063.2|/1.08199e-83/voltage-dependent calcium channel gamma-like subunit [Homo sapiens]