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{"sheet":"Table S3","index":0,"n_rows":107,"n_cols":16,"rows_kept":107,"cut":false,"hidden":false,"merged":[[76,4,77,4],[76,5,77,5],[53,6,54,6],[55,6,56,6],[55,4,56,4],[55,5,56,5],[61,4,62,4],[61,5,62,5],[70,4,72,4],[66,4,68,4],[66,5,68,5],[70,6,72,6],[53,4,54,4],[66,6,68,6],[61,6,62,6],[48,1,50,1],[61,1,62,1],[53,1,54,1],[55,1,56,1],[80,1,81,1],[80,2,81,2],[82,0,83,0],[88,0,89,0],[86,0,87,0],[88,1,89,1],[88,2,89,2],[86,1,87,1],[86,2,87,2],[41,2,42,2],[48,0,50,0],[90,2,91,2],[95,2,96,2],[66,2,68,2],[82,2,83,2],[46,2,47,2],[92,2,93,2],[53,0,54,0],[61,0,62,0],[55,0,56,0],[78,0,79,0],[78,1,79,1],[78,2,79,2],[76,0,77,0],[76,1,77,1],[76,2,77,2],[48,2,50,2],[53,2,54,2],[46,0,47,0],[46,1,47,1],[61,2,62,2],[55,2,56,2],[70,0,72,0],[70,1,72,1],[86,4,87,4],[86,5,87,5],[86,6,87,6],[82,6,83,6],[95,5,96,5],[95,6,96,6],[82,3,83,3],[80,3,81,3],[80,4,81,4],[80,5,81,5],[80,6,81,6],[88,3,89,3],[86,3,87,3],[92,3,93,3],[90,3,91,3],[95,3,96,3],[90,0,91,0],[90,1,91,1],[78,4,79,4],[78,5,79,5],[82,4,83,4],[82,5,83,5],[90,5,91,5],[90,6,91,6],[88,6,89,6],[88,4,89,4],[88,5,89,5],[92,6,93,6],[92,4,93,4],[92,5,93,5],[95,4,96,4],[90,4,91,4],[41,0,42,0],[41,1,42,1],[41,3,42,3],[41,6,42,6],[41,4,42,4],[41,5,42,5],[82,1,83,1],[80,0,81,0],[66,0,68,0],[66,1,68,1],[76,6,77,6],[78,6,79,6],[78,3,79,3],[76,3,77,3],[66,3,68,3],[61,3,62,3],[55,3,56,3],[70,5,72,5],[70,2,72,2],[70,3,72,3],[46,4,47,4],[48,4,50,4],[53,5,54,5],[46,5,47,5],[48,6,50,6],[48,3,50,3],[53,3,54,3],[46,3,47,3],[46,6,47,6],[48,5,50,5],[78,9,79,9],[76,10,77,10],[78,10,79,10],[76,9,77,9],[78,14,79,14],[78,15,79,15],[76,11,77,11],[76,13,77,13],[80,9,81,9],[80,10,81,10],[82,13,83,13],[80,13,81,13],[80,14,81,14],[80,15,81,15],[70,13,72,13],[70,14,72,14],[82,9,83,9],[82,10,83,10],[82,14,83,14],[82,15,83,15],[70,9,72,9],[55,11,56,11],[55,10,56,10],[61,9,62,9],[55,9,56,9],[70,15,72,15],[66,14,68,14],[66,15,68,15],[76,14,77,14],[76,15,77,15],[70,11,72,11],[66,11,68,11],[66,9,68,9],[66,10,68,10],[55,7,56,7],[55,8,56,8],[82,11,83,11],[80,11,81,11],[82,7,83,7],[80,7,81,7],[80,8,81,8],[78,11,79,11],[78,13,79,13],[46,9,47,9],[41,9,42,9],[37,8,40,8],[37,9,40,9],[33,8,36,8],[33,9,36,9],[33,11,36,11],[33,13,36,13],[33,14,36,14],[33,15,36,15],[46,14,47,14],[41,14,42,14],[37,15,40,15],[37,14,40,14],[41,15,42,15],[41,11,42,11],[41,13,42,13],[41,10,42,10],[41,8,42,8],[27,15,28,15],[27,13,28,13],[27,14,28,14],[27,11,28,11],[16,15,17,15],[16,14,17,14],[16,13,17,13],[16,3,17,3],[16,4,17,4],[16,0,17,0],[16,7,17,7],[16,6,17,6],[16,1,17,1],[16,2,17,2],[16,10,17,10],[16,11,17,11],[16,5,17,5],[27,9,28,9],[20,9,23,9],[24,11,25,11],[24,14,25,14],[24,13,25,13],[20,13,23,13],[20,14,23,14],[20,15,23,15],[24,15,25,15],[27,10,28,10],[8,11,9,11],[8,13,9,13],[8,14,9,14],[8,15,9,15],[20,11,23,11],[20,10,23,10],[27,6,28,6],[27,7,28,7],[53,10,54,10],[53,13,54,13],[8,4,9,4],[8,3,9,3],[20,3,23,3],[24,3,25,3],[27,3,28,3],[20,6,23,6],[20,7,23,7],[37,6,40,6],[37,5,40,5],[37,3,40,3],[33,4,36,4],[33,5,36,5],[33,3,36,3],[37,4,40,4],[37,7,40,7],[41,7,42,7],[33,6,36,6],[8,10,9,10],[8,9,9,9],[88,7,89,7],[90,8,91,8],[92,8,93,8],[88,9,89,9],[90,9,91,9],[92,9,93,9],[88,8,89,8],[92,7,93,7],[95,8,96,8],[95,7,96,7],[90,7,91,7],[102,6,104,6],[102,7,104,7],[102,8,104,8],[102,9,104,9],[99,9,100,9],[99,8,100,8],[97,6,98,6],[66,7,68,7],[66,8,68,8],[76,7,77,7],[76,8,77,8],[86,8,87,8],[86,7,87,7],[86,9,87,9],[82,8,83,8],[78,7,79,7],[78,8,79,8],[61,7,62,7],[61,8,62,8],[70,7,72,7],[70,8,72,8],[99,7,100,7],[99,6,100,6],[97,7,98,7],[97,8,98,8],[97,9,98,9],[95,9,96,9],[95,0,96,0],[97,0,98,0],[33,0,36,0],[37,0,40,0],[99,0,100,0],[92,0,93,0],[92,1,93,1],[102,1,104,1],[95,1,96,1],[102,2,104,2],[102,0,104,0],[102,3,104,3],[102,4,104,4],[102,5,104,5],[8,1,9,1],[8,2,9,2],[33,1,36,1],[33,2,36,2],[37,1,40,1],[37,2,40,2],[2,0,4,0],[2,1,4,1],[2,2,4,2],[6,1,7,1],[6,2,7,2],[6,0,7,0],[8,0,9,0],[99,4,100,4],[99,5,100,5],[97,1,98,1],[97,2,98,2],[99,2,100,2],[99,1,100,1],[99,3,100,3],[97,5,98,5],[97,3,98,3],[97,4,98,4],[24,0,25,0],[20,0,23,0],[20,2,23,2],[27,0,28,0],[27,1,28,1],[27,2,28,2],[24,1,25,1],[24,2,25,2],[20,1,23,1],[46,10,47,10],[46,11,47,11],[48,10,50,10],[48,9,50,9],[48,7,50,7],[46,7,47,7],[53,7,54,7],[53,8,54,8],[53,9,54,9],[16,8,17,8],[27,8,28,8],[20,8,23,8],[24,8,25,8],[24,10,25,10],[24,7,25,7],[24,9,25,9],[20,4,23,4],[20,5,23,5],[24,4,25,4],[24,5,25,5],[27,4,28,4],[27,5,28,5],[16,9,17,9],[33,10,36,10],[8,7,9,7],[8,5,9,5],[8,6,9,6],[33,7,36,7],[8,8,9,8],[24,6,25,6],[2,8,4,8],[2,15,4,15],[2,14,4,14],[2,11,4,11],[2,13,4,13],[2,9,4,9],[2,10,4,10],[6,9,7,9],[6,11,7,11],[6,15,7,15],[6,10,7,10],[6,8,7,8],[6,13,7,13],[6,14,7,14],[6,5,7,5],[6,6,7,6],[2,7,4,7],[2,4,4,4],[2,3,4,3],[6,3,7,3],[6,4,7,4],[2,6,4,6],[2,5,4,5],[6,7,7,7],[37,11,40,11],[37,13,40,13],[46,15,47,15],[48,15,50,15],[48,14,50,14],[48,8,50,8],[46,13,47,13],[37,10,40,10],[46,8,47,8],[88,13,89,13],[86,13,87,13],[92,13,93,13],[86,10,87,10],[92,11,93,11],[90,11,91,11],[90,10,91,10],[88,11,89,11],[88,10,89,10],[61,15,62,15],[61,14,62,14],[53,11,54,11],[48,11,50,11],[53,15,54,15],[70,10,72,10],[61,11,62,11],[61,10,62,10],[55,15,56,15],[92,15,93,15],[90,15,91,15],[97,15,98,15],[95,15,96,15],[102,15,104,15],[99,15,100,15],[92,14,93,14],[95,14,96,14],[102,14,104,14],[99,14,100,14],[102,13,104,13],[99,13,100,13],[97,13,98,13],[97,14,98,14],[53,14,54,14],[55,14,56,14],[90,14,91,14],[88,15,89,15],[86,15,87,15],[86,14,87,14],[88,14,89,14],[92,10,93,10],[95,10,96,10],[97,10,98,10],[102,10,104,10],[99,10,100,10],[95,11,96,11],[97,11,98,11],[102,11,104,11],[99,11,100,11],[48,13,50,13],[66,13,68,13],[61,13,62,13],[55,13,56,13],[90,13,91,13],[95,13,96,13],[86,11,87,11]]}
["Supplementary Table 1: Germline mutation classified as benign or variants of unknown significance and clinical characteristics of the patients with those mutations in this study"]
["Patient\nID","Gene","Reference\nsequence","dbSNP Accession Number","Nucleotide change","Amino acid change","Type of mutation","dbSNP","ClinVar","SIFT","PolyPhen2","Previous\ncancer","Cancer in first- or second- degress relatives","Age at","Sex","Primary organ of tumor *"]
[19.0,"BRCA2","NM_000059","rs397507568","c.10150 C>T","p.Arg3384Ter","Nonsense","VUS","Conflicting","-","-","None","1 breast,",65.0,"M","Gallbladder"]
[{"$nulls":12},"1 lung and"]
[{"$nulls":12},"1 esophageal"]
[1.0,"MSH6","NM_000179","rs63750554","c.3772 C>G","p.Gln1258Glu","Missense","-","VUS","-","Benign","None","None",44.0,"M","IHBD"]
[58.0,"BRCA2","NM_000059","rs587782191","c.7507G>A","p.Val2503Ile","Missense","VUS","VUS","-","Benign","-","1 breast and",51.0,"M","IHBD"]
[{"$nulls":12},"1 lung"]
[58.0,"MLH1","NM_000249","rs63751713","c.1744C>G","p.Leu582Val","Missense","VUS","VUS","-","Benign","-","1 breast and",51.0,"M","IHBD"]
[{"$nulls":12},"1 lung"]
[55.0,"BRCA2","NM_000059","rs11571640","c.964 A>C","p.Lys322Gln","Missense","other","Conflicting","Damaging","Probably damaging","bladder","1 gastric",75.0,"M","IHBD"]
[55.0,"CHEK2","NM_007194","-","c.790 G>T","p.Ala264Ser","Missense","-","-","-","Benign","bladder","1 gastric",75.0,"M","IHBD"]
[40.0,"BRIP1","NM_032043","rs550707862","c.587A>G","p.Asn196Ser","Missense","VUS","Conflicting","-","Benign","gastric","2 gastric",65.0,"M","Ampulla of Vater"]
[39.0,"PMS2","NM_000535","rs63750668","c.1688G>A","p.Arg563Gln","Missense","VUS","Conflicting","-","Benign","-","3 gastric",67.0,"M","Gallbladder"]
[38.0,"MRE11A","NM_005590","rs147771140","c.469A>G","p.Met157Val","Missense","Likely benign","Conflicting","-","Benign","gastric, bladder","-",75.0,"M","IHBD"]
[26.0,"BRCA1","NM_007294","rs80357028","c.5255 C>G","p.Ala1752Gly","Missense","VUS","VUS","-","Benign","-","2 colorectal and 1 liver",64.0,"M","EHBD"]
[24.0,"BRCA1","NM_007294","-","c.2210 C>T","p.Thr737Ile","Missense","-","-","-","Benign","-","2 gastric and",74.0,"F","Gallbladder"]
[{"$nulls":12},"1 thyroid"]
[17.0,"BRIP1","NM_032043","rs201024366","c.1935 +7 T>C","-","Splice","-","-","-","-","-","2 biliary tract",66.0,"F","EHBD"]
[17.0,"MSH6","NM_000179","rs63750753","c.3260 C>A","p.Pro1087His","Missense","Other","VUS","-","Probably damaging","-","2 biliary tract",66.0,"F","EHBD"]
[7.0,"BRIP1","NM_032043","rs140233356","c.2830 C>G","p.Gln944Glu","Missense","VUS","VUS","-","Possibly damaging","-","1 lung,",76.0,"M","EHBD"]
[{"$nulls":12},"1 colorectal,"]
[{"$nulls":12},"1 gastric and"]
[{"$nulls":12},"1 pharyngeal"]
[8.0,"ATM","NM_000051","rs55812024","c.2466 +7 A>G","-","Splice","Benign","Benign","-","-","-","1 gastric and",78.0,"M","IHBD"]
[{"$nulls":12},"1 uterus"]
[2.0,"MSH6","NM_000179","-","c.3801 +4 T>C","-","Splice","-","-","-","-","-","-",48.0,"M","IHBD"]
[16.0,"BRIP1","NM_032043","rs571108955","c.2324 A>G","p.Asn775Ser","Missense","VUS","VUS","-","Probably damaging","-","2 gastric and",72.0,"F","Gallbladder"]
[{"$nulls":12},"1 colorectal"]
[51.0,"BRCA2","NM_000059","-","c.1340C>A","p.Pro447Gln","Missense","-","-","-","Possibly damaging","-","-",43.0,"M","Gallbladder"]
[51.0,"BRIP1","NM_032043","-","c.787C>T","p.Leu263Phe","Missense","-","-","-","Probably damaging","-","-",43.0,"M","Gallbladder"]
[42.0,"BRCA2","NM_000059","rs79456940","c.6325G>A","p.Val2109Ile","Missense","VUS","Conflicting","-","Benign","lung, colorectal","2 colorectal",73.0,"M","EHBD"]
[42.0,"MLH1","NM_000249","rs4986984","c.649C>T","p.Arg217Cys","Missense","VUS","VUS","-","Probably damaging","lung, colorectal","2 colorectal",73.0,"M","EHBD"]
[43.0,"MSH2","NM_000251","-","c.1695A>C","p.Lys565Asn","Missense","-","-","-","Possibly damaging","-","2 breast,",69.0,"F","Gallbladder"]
[{"$nulls":12},"1 prostate,"]
[{"$nulls":12},"1 gastric and"]
[{"$nulls":12},"1 esophageal"]
[43.0,"MSH2","NM_000251","-","c.942 +3_+4 delAA","-","Splice","-","-","-","-","-","2 breast,",69.0,"F","Gallbladder"]
[{"$nulls":12},"1 prostate,"]
[{"$nulls":12},"1 gastric and"]
[{"$nulls":12},"1 esophageal"]
[6.0,"PALB2","NM_024675","rs201657283","c.3307 G>A","p.Val1103Met","Missense","VUS","VUS","-","Possibly damaging","gastric","1 lung and",69.0,"M","EHBD"]
[{"$nulls":12},"1 liver"]
[52.0,"MSH6","NM_000179","rs545466048","c.4002-10 T>A","-","Splice","VUS","VUS","-","-","colorectal","1 biliary tract and 1 uterus",73.0,"M","IHBD"]
[23.0,"MUTYH","NM_001128425","rs533899702","c.554G>A","p.Arg185Gln","Missense","-","-","-","-","-","1 biliary tract",59.0,"M","Gallbladder"]
[13.0,"MSH6","NM_000179","rs545466048","c.4002 -10 T>A","-","Splice","VUS","VUS","-","-","prostate","1 breast",74.0,"M","Gallbladder"]
[46.0,"MSH6","NM_000179","rs63750065","c.1190 A>G","p.Tyr397Cys","Missense","VUS","VUS","-","Probably damaging","-","1 gastric and",76.0,"F","IHBD"]
[{"$nulls":12},"1 lung"]
[4.0,"CDH1","NM_004360","rs116093741","c.1018 A>G","p.Thr340Ala","Missense","VUS","Conflicting","-","Benign","None","1 gastric,",62.0,"M","Gallbladder"]
[{"$nulls":12},"1 colorectal and"]
[{"$nulls":12},"1 lung"]
[10.0,"TP53","NM_000546","rs201382018","c.31G>C","p.Glu11Gln","Missense","VUS","VUS","-","Probably damaging","uterus","1 gastric",68.0,"F","Gallbladder"]
[10.0,"BRCA1","NM_007294","rs80356909","c.4729T>C","p.Ser1577Pro","Missense","Other","Conflicting","-","Benign","uterus","1 gastric",68.0,"F","Gallbladder"]
[31.0,"RAD50","NM_005732","-","c.3380C>T","p.Thr1127Ile","Missense","-","-","-","-","-","1 uterus and",65.0,"M","EHBD"]
[{"$nulls":12},"1 ovarian"]
[14.0,"BRIP1","NM_032043","-","c.409 A>G","p.Lys137Glu","Missense","-","-","-","Probably damaging","-","1 biliary tract ",45.0,"M","Ampulla of Vater"]
[{"$nulls":12},"and 1 lung"]
[33.0,"MUTYH","NM_001128425","-","c.1541C>A","p.Ser514Tyr","Missense","-","-","-","-","-","1 biliary tract and 1 gastric",65.0,"M","EHBD"]
[15.0,"BRCA2","NM_000059","-","c.3184 C>T","p.Pro1062Ser","Missense","-","-","-","Benign","colorectal","1 biliary tract and 1 lung",59.0,"M","EHBD"]
[18.0,"BRIP1","NM_032043","rs200062099","c.1442 G>A","p.Gly481Asp","Missense","VUS","VUS","-","Probably damaging","-","-",26.0,"M","IHBD"]
[12.0,"MSH6","NM_000179","rs201096652","c.1937A>G","p.Lys646Arg","Missense","-","-","-","Benign","gastric, esophagus","1 colorectal",67.0,"M","Ampulla of Vater"]
[49.0,"PALB2","NM_024675","-","c.1379A>G","p.Gln460Arg","Missense","VUS","VUS","-","Benign","-","1 breast and",76.0,"M","EHBD"]
[{"$nulls":12},"1 gastric"]
[57.0,"MLH1","NM_000249","rs63751713","c.1744C>G","p.Leu582Val","Missense","VUS","VUS","-","Benign","-","1 breast",55.0,"F","IHBD"]
[50.0,"BARD1","NM_000465","rs16852741","c.556 A>G","p.Ser186Gly","Missense","-","-","-","Benign","-","-",48.0,"F","Gallbladder"]
[20.0,"RAD50","NM_005732","rs549559726","c.2209 C>G","p.Gln737Glu","Missense","VUS","VUS","-","Benign","-","1 gastric",48.0,"M","Gallbladder"]
[45.0,"PALB2","NM_024675","rs571063157","c.734 C>T","p.Ala245Val","Missense","VUS","VUS","-","Benign","-","1 pancreatic,",64.0,"F","IHBD"]
[{"$nulls":12},"1 lung, 1 uterus and"]
[{"$nulls":12},"1 pharyngeal"]
[60.0,"BRCA2","NM_000059","rs80358423","c.1343G>A","p.Arg448His","Missense","VUS","VUS","-","Benign","-","1 biliary tract",58.0,"M","EHBD"]
[73.0,"MSH2","NM_000251","-","c.959 C>T","p.Thr320Ile","Missense","-","-","-","Benign","-","1 gastric,",67.0,"F","IHBD"]
[{"$nulls":12},"1 uterus and"]
[{"$nulls":12},"1 renal"]
[75.0,"BRCA1","NM_007294","rs80357272","c.3448C>T","p.Pro1150Ser","Missense","VUS","VUS","-","Probably damaging","-","2 colorectal",72.0,"M","EHBD"]
[75.0,"MSH2","NM_000251","rs63751260","c.118 G>A","p.Gly40Ser","Missense","VUS","VUS","-","Benign","-","2 colorectal",72.0,"M","EHBD"]
[75.0,"MSH6","NM_000179","rs587778531","c.1063G>A","p.Gly355Ser","Missense","VUS","VUS","-","Benign","-","2 colorectal",72.0,"M","EHBD"]
[78.0,"BRCA2","NM_000059","rs55794205","c.6322 C>T","p.Arg2108Cys","Missense","Other","Conflicting","-","Benign","-","2 gastric and",60.0,"F","Gallbladder"]
[{"$nulls":12},"1 ovarian"]
[78.0,"NBN","NM_002485","rs182756889","c.505 C>T","p.Arg169Cys","Missense","VUS","VUS","-","Benign","-","2 gastric and",60.0,"F","Gallbladder"]
[{"$nulls":12},"1 ovarian"]
[72.0,"PMS1","NM_000534","-","c.830 G>A","p.Arg277Gln","Missense","-","-","-","Probably damaging","-","2 gastric and",62.0,"M","EHBD"]
[{"$nulls":12},"1 liver"]
[72.0,"MLH1","NM_000249","rs63751713","c.1744C>G","p.Leu582Val","Missense","VUS","VUS","-","Benign","-","2 gastric and",62.0,"M","EHBD"]
[{"$nulls":12},"1 liver"]
[64.0,"BRCA2","NM_000059","rs80358762","c.53 G>A","p.Arg18His","Missense","VUS","Benign","-","Probably damaging","-","1 colorectal",49.0,"F","IHBD"]
[64.0,"RAD50","NM_005732","rs549559726","c.2209 C>G","p.Gln737Glu","Missense","VUS","VUS","-","Benign","-","1 colorectal",49.0,"F","IHBD"]
[80.0,"BRCA2","NM_000059","rs80358457","c.1744A>C","p.Thr582Pro","Missense","VUS","Benign","-","Probably damaging","-","1 pancreatic",73.0,"M","EHBD"]
[{"$nulls":12},"and 1 gastric"]
[77.0,"ATM","NM_000051","rs201773026","c.125 A>G","p.His42Arg","Missense","Other","Likely benign","-","Benign","-","1 pancreatic",66.0,"M","IHBD"]
[{"$nulls":12},"and 1 uterus"]
[77.0,"ATM","NM_000051","rs55870064","c.4949A>G","p.Asn1650Ser","Missense","Other","Benign","Tolerated","Benign","-","1 pancreatic",66.0,"M","IHBD"]
[{"$nulls":12},"and 1 uterus"]
[77.0,"MSH6","NM_000179","rs545466048","c.4002-10T>A","-","Splice","VUS","VUS","-","-","-","1 pancreatic",66.0,"M","IHBD"]
[{"$nulls":12},"and 1 uterus"]
[65.0,"ATM","NM_000051","rs3218708","c.2804 C>G","p.Thr935Arg","Missense","VUS","VUS","-","Benign","-","1 ovarian",75.0,"F","Ampulla of Vater"]
[67.0,"STK11","NM_000455","-","c.1062_1063 insGACATCGAGGAT","p.Glu357_Ile360 dup","Insertion","-","-","-","-","-","2 pancreatic",78.0,"M","EHBD"]
[{"$nulls":12},"and 1 lung"]
[71.0,"MSH2","NM_000251","-","c.266 T>C","p.Val89Ala","Missense","-","-","-","Benign","-","1 biliary tract",64.0,"M","EHBD"]
[{"$nulls":12},"and 1 liver"]
[69.0,"BRIP1","NM_032043","rs550707862","c.587 A>G","p.Asn196Ser","Missense","VUS","Conflicting","-","Benign","-","1 prostate and",49.0,"F","Gallbladder"]
[{"$nulls":12},"1 liver"]
[79.0,"BRCA2","NM_000059","rs11571640","c.964 A>C","p.Lys322Gln","Missense","Other","Conflicting","Damaging","Probably damaging","-","1 biliary tract",63.0,"M","Gallbladder"]
[74.0,"PALB2","NM_024675","-","c.718 C>A","p.Pro240Thr","Missense","-","-","-","Benign","-","2 colorectal,",81.0,"F","Gallbladder"]
[{"$nulls":12},"1 gastric and"]
[{"$nulls":12},"1 prostate"]
[63.0,"TP53","NM_000546","rs201753350","c.91 G>A","p.Val31Ile","Missense","VUS","Conflicting","-","Benign","-","-",44.0,"F","Gallbladder"]
["* EHBD: extrahepatic bile duct, IHBD: intrahepatic bile duct"]