PHYLUM C57BL/6J DBA/2J name Mean (%) SD (%) Min (%) Max (%) Median (%) Mean (%) SD (%) Min (%) Max (%) Median (%) P-value Actinobacteria 16.1320 11.8567 1.1085 35.1040 17.3093 0.9192 0.314189666 0.3897 1.2596 0.9226 0.0097 Bacteroidetes 17.9199 7.8384 10.4564 32.7491 15.8599 9.2652 4.754888468 4.7170 17.0991 8.1615 0.0384 Deferribacteres 0.0075 0.0012 0.0069 0.0101 0.0070 0.3087 0.32500943 0.0479 0.9315 0.2457 0.0311 Firmicutes 62.2697 8.8588 48.9181 73.5143 60.9154 87.7234 5.116535871 79.1284 92.9587 88.1187 0.0001 GENERA C57BL/6J DBA/2J name Mean (%) SD (%) Min (%) Max (%) Median (%) Mean (%) SD (%) Min (%) Max (%) Median (%) P-value Bifidobacterium 15.1362 12.0810 0.0073 34.4396 16.0227 0.0301 0.0528 0.0068 0.1378 0.0078 0.0112 Flavonifractor 0.1117 0.0635 0.0345 0.2005 0.1232 0.0203 0.0136 0.0068 0.0413 0.0197 0.0055 Lactobacillus 20.9157 10.2091 9.3180 33.9386 17.9266 48.8074 9.7856 30.2239 59.0038 51.1725 0.0004 Mucispirillum 0.0074 0.0012 0.0068 0.0100 0.0070 0.3077 0.3239 0.0478 0.9285 0.2449 0.0311 Peptococcus 0.0074 0.0012 0.0068 0.0100 0.0070 0.0551 0.0466 0.0068 0.1309 0.0514 0.0199 Ruminococcus2 0.4576 0.4163 0.0068 1.0088 0.2980 0.0359 0.0285 0.0136 0.0815 0.0206 0.0317 Sporobacter 0.0315 0.0156 0.0138 0.0602 0.0342 0.0071 0.0007 0.0068 0.0086 0.0069 0.0030 Streptococcus 0.0074 0.0012 0.0068 0.0100 0.0070 0.0587 0.0471 0.0068 0.1455 0.0521 0.0143 Turicibacter 7.2518 4.1205 1.1828 14.4080 6.7737 0.0097 0.0045 0.0068 0.0172 0.0069 0.0013 unclassified_Lactobacillaceae 0.5980 0.7831 0.0068 1.9123 0.0071 2.3015 1.2615 0.8198 3.4459 2.6337 0.0126 unclassified_Porphyromonadaceae 2.7444 2.5715 0.3467 8.0108 2.0952 0.2241 0.1810 0.0409 0.5498 0.1885 0.0365 unclassified_Streptococcaceae 0.0074 0.0012 0.0068 0.0100 0.0070 0.3522 0.2477 0.0068 0.6616 0.3631 0.0034 OTUs C57BL/6J DBA/2J name (Phylum;Family;Genus;Species) Mean (%) SD (%) Min (%) Max (%) Median (%) Mean (%) SD (%) Min (%) Max (%) Median (%) P-value OTU_104_Bacteroidetes;Bacteroidales 0.3054 0.1920 0.0947 0.6329 0.2349 0.0415 0.034090017 0.0134 0.1080 0.0335 0.0070 OTU_106_Firmicutes;Clostridiales;Lachnospiraceae;Coprococcus 0.1273 0.0666 0.0470 0.2426 0.1227 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0011 OTU_107_Firmicutes;Clostridiales;Lachnospiraceae 0.3921 0.4257 0.0339 1.1295 0.1275 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0500 OTU_11_Firmicutes;Clostridiales;Lachnospiraceae;Ruminococcus gnavus 3.5089 3.7785 0.0068 11.1712 3.3813 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0454 OTU_12_Firmicutes;Clostridiales;Lachnospiraceae 0.6676 0.5355 0.2426 1.7341 0.4698 2.2532 1.578164223 0.1940 4.4251 1.9383 0.0289 OTU_121_Firmicutes;Clostridiales;[Mogibacteriaceae] 0.0538 0.0338 0.0068 0.1016 0.0554 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0063 OTU_124_Deferribacteres;Deferribacterales;Deferribacteraceae;Mucispirillum schaedleri 0.0073 0.0011 0.0067 0.0097 0.0068 0.3013 0.31741844 0.0468 0.9098 0.2401 0.0312 OTU_127_Firmicutes;Clostridiales;Ruminococcaceae;Clostridium thermosuccinogenes 0.3280 0.1804 0.1386 0.6134 0.3522 0.0092 0.00534306 0.0067 0.0200 0.0068 0.0013 OTU_140_Firmicutes;Clostridiales 0.0083 0.0028 0.0067 0.0142 0.0068 0.2038 0.184522639 0.0266 0.5418 0.1412 0.0165 OTU_145_Firmicutes;Clostridiales 0.0092 0.0052 0.0067 0.0208 0.0068 0.1151 0.075644474 0.0068 0.2363 0.1135 0.0034 OTU_147_Firmicutes;Clostridiales;Ruminococcaceae 0.0341 0.0187 0.0135 0.0682 0.0341 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0048 OTU_151_Firmicutes;Clostridiales;Ruminococcaceae;Oscillospira 0.1034 0.0575 0.0338 0.1753 0.1208 0.0162 0.010110484 0.0067 0.0338 0.0150 0.0039 OTU_156_Firmicutes;Clostridiales;Ruminococcaceae 0.0360 0.0111 0.0203 0.0554 0.0356 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0001 OTU_163_Firmicutes;Clostridiales;[Mogibacteriaceae] 0.0329 0.0152 0.0142 0.0604 0.0339 0.0103 0.003402635 0.0067 0.0135 0.0108 0.0045 OTU_166_Firmicutes;Clostridiales;Christensenellaceae 0.0278 0.0148 0.0097 0.0427 0.0341 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0056 OTU_178_Firmicutes;Clostridiales;Ruminococcaceae 0.0595 0.0248 0.0203 0.0948 0.0624 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0003 OTU_18_Firmicutes;Clostridiales 0.1206 0.1189 0.0068 0.3408 0.1007 2.3610 1.554676877 0.0068 3.7540 3.0099 0.0028 OTU_180_Firmicutes;Clostridiales;Lachnospiraceae 0.0073 0.0011 0.0067 0.0097 0.0068 0.0877 0.055391418 0.0419 0.1958 0.0708 0.0026 OTU_181_Firmicutes;Lactobacillales;Streptococcaceae;Streptococcus 0.0073 0.0011 0.0067 0.0097 0.0068 0.0587 0.048660914 0.0067 0.1494 0.0510 0.0168 OTU_184_Firmicutes;Clostridiales;Lachnospiraceae;Coprococcus 0.0395 0.0302 0.0135 0.0974 0.0273 0.0092 0.003254576 0.0067 0.0134 0.0076 0.0334 OTU_185_Firmicutes;Clostridiales;Christensenellaceae 0.0330 0.0122 0.0205 0.0498 0.0271 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0003 OTU_189_Firmicutes;Clostridiales;Ruminococcaceae 0.0511 0.0307 0.0205 0.0974 0.0336 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0050 OTU_195_Firmicutes;Clostridiales;Lachnospiraceae 0.0073 0.0011 0.0067 0.0097 0.0068 0.0551 0.037157055 0.0200 0.1089 0.0468 0.0056 OTU_197_Firmicutes;Clostridiales;Peptococcaceae 0.0073 0.0011 0.0067 0.0097 0.0068 0.0539 0.045680291 0.0067 0.1283 0.0502 0.0199 OTU_198_Firmicutes;Clostridiales 0.0673 0.0436 0.0068 0.1109 0.0886 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0063 OTU_199_Firmicutes;Erysipelotrichales;Erysipelotrichaceae 0.0161 0.0120 0.0067 0.0409 0.0135 0.0589 0.040809036 0.0067 0.1215 0.0584 0.0223 OTU_2_Actinobacteria;Bifidobacteriales;Bifidobacteriaceae;Bifidobacterium pseudolongum 14.8272 11.8419 0.0071 33.7446 15.7014 0.0295 0.05177304 0.0067 0.1350 0.0076 0.0112 OTU_200_Firmicutes;Clostridiales 0.0656 0.0507 0.0208 0.1494 0.0474 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0169 OTU_202_Firmicutes;Clostridiales;[Mogibacteriaceae] 0.0255 0.0131 0.0071 0.0487 0.0205 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0057 OTU_21_Bacteroidetes;Bacteroidales 1.3172 1.1668 0.1779 3.3982 0.8524 0.1302 0.066968861 0.0334 0.2140 0.1329 0.0310 OTU_213_Firmicutes;Clostridiales;Lachnospiraceae 0.0320 0.0144 0.0195 0.0609 0.0273 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0014 OTU_219_Firmicutes;Clostridiales;Lachnospiraceae 0.0233 0.0129 0.0068 0.0406 0.0271 0.0081 0.002757491 0.0067 0.0136 0.0067 0.0174 OTU_235_Firmicutes;Clostridiales 0.0265 0.0142 0.0135 0.0487 0.0268 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0066 OTU_24_Firmicutes;Clostridiales 0.1466 0.0958 0.0545 0.3116 0.1141 4.3801 2.009482808 2.0894 6.8933 3.9561 0.0002 OTU_244_Firmicutes;Clostridiales;Ruminococcaceae;Ruminococcus 0.0073 0.0011 0.0067 0.0097 0.0068 0.0293 0.024704932 0.0067 0.0608 0.0275 0.0364 OTU_25_Firmicutes;Clostridiales 1.4802 0.9590 0.4767 3.0075 1.4520 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0033 OTU_253_Firmicutes;Clostridiales;Lachnospiraceae 0.0161 0.0084 0.0068 0.0285 0.0136 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0228 OTU_254_Firmicutes;Clostridiales 0.0248 0.0160 0.0068 0.0406 0.0341 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0209 OTU_256_Firmicutes;Lactobacillales;Lactobacillaceae;Lactobacillus 0.0092 0.0031 0.0067 0.0135 0.0071 0.0198 0.007047385 0.0134 0.0270 0.0194 0.0039 OTU_265_Firmicutes;Clostridiales;Lachnospiraceae;Ruminococcus gnavus 0.0122 0.0051 0.0068 0.0213 0.0134 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0308 OTU_268_Firmicutes;Clostridiales 0.0477 0.0443 0.0068 0.1210 0.0485 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0469 OTU_27_Firmicutes;Clostridiales;Lachnospiraceae 0.1980 0.1453 0.0203 0.4765 0.1500 0.6028 0.355767268 0.2675 1.2157 0.5344 0.0182 OTU_279_Firmicutes;Clostridiales;Ruminococcaceae;Oscillospira 0.0604 0.0280 0.0271 0.0881 0.0640 0.1933 0.143038434 0.0466 0.4524 0.1514 0.0339 OTU_283_Firmicutes;Clostridiales;Ruminococcaceae 0.0159 0.0089 0.0068 0.0292 0.0136 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0341 OTU_284_Firmicutes;Clostridiales 0.0131 0.0057 0.0068 0.0203 0.0135 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0251 OTU_29_Firmicutes;Clostridiales;Lachnospiraceae 0.0370 0.0106 0.0195 0.0485 0.0403 1.0756 0.924828318 0.1765 2.7952 0.8356 0.0122 OTU_294_Firmicutes;Clostridiales;Lachnospiraceae;Coprococcus 0.0458 0.0368 0.0068 0.0954 0.0339 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0265 OTU_295_Actinobacteria;Actinomycetales;Corynebacteriaceae;Corynebacterium 0.0073 0.0011 0.0067 0.0097 0.0068 0.0104 0.003439111 0.0067 0.0136 0.0109 0.0424 OTU_296_Firmicutes;Clostridiales;Ruminococcaceae;Clostridium thermosuccinogenes 0.0344 0.0222 0.0068 0.0745 0.0292 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0122 OTU_3_Firmicutes;Lactobacillales;Lactobacillaceae;Lactobacillus 2.3176 2.9710 0.0067 6.8534 0.0203 12.8961 7.668206873 3.6662 20.4796 14.8989 0.0061 OTU_303_Firmicutes;Clostridiales;Ruminococcaceae 0.0112 0.0032 0.0068 0.0139 0.0134 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0105 OTU_327_Firmicutes;Lactobacillales;Lactobacillaceae;Lactobacillus 0.0073 0.0011 0.0067 0.0097 0.0068 4.3730 4.909481247 0.0067 10.7016 3.6222 0.0371 OTU_33_Firmicutes;Clostridiales;Lachnospiraceae;Ruminococcus gnavus 0.1648 0.0778 0.0693 0.2921 0.1494 0.6723 0.428969543 0.2430 1.2561 0.5114 0.0102 OTU_331_Firmicutes;Clostridiales;Lachnospiraceae 0.0287 0.0146 0.0134 0.0554 0.0292 0.0115 0.005264995 0.0067 0.0203 0.0108 0.0201 OTU_35_Firmicutes;Clostridiales;Lachnospiraceae 0.0576 0.0425 0.0142 0.1363 0.0470 0.4675 0.236756282 0.1215 0.7852 0.4713 0.0009 OTU_38_Firmicutes;Clostridiales;Ruminococcaceae;Oscillospira 0.6250 0.3652 0.0812 1.0702 0.6885 0.2282 0.18900496 0.0334 0.5199 0.1714 0.0358 OTU_4_Firmicutes;Lactobacillales;Lactobacillaceae;Lactobacillus reuteri 0.9160 1.2621 0.0067 3.2136 0.0069 9.3292 3.079400099 5.7177 12.7082 9.7154 <0.0001 OTU_40_Firmicutes;Clostridiales;Lachnospiraceae;Ruminococcus gnavus 0.4423 0.4201 0.0067 1.0226 0.2356 0.0271 0.027669729 0.0067 0.0799 0.0169 0.0352 OTU_44_Bacteroidetes;Bacteroidales 0.1664 0.0911 0.0271 0.3019 0.1802 0.3014 0.095991248 0.1803 0.4456 0.2879 0.0248 OTU_46_Firmicutes;Clostridiales 0.1441 0.1133 0.0068 0.3273 0.1753 1.4614 0.704233176 0.7615 2.7088 1.2890 0.0005 OTU_47_Firmicutes;Clostridiales 0.2255 0.2041 0.0273 0.5842 0.1040 0.7909 0.437912357 0.1806 1.3493 0.7604 0.0107 OTU_5_Firmicutes;Turicibacterales;Turicibacteraceae;Turicibacter 7.0967 4.0394 1.1589 14.1262 6.6311 0.0095 0.00442612 0.0067 0.0168 0.0068 0.0013 OTU_52_Firmicutes;Clostridiales 0.0092 0.0033 0.0067 0.0139 0.0071 0.0859 0.066304444 0.0067 0.1630 0.0859 0.0105 OTU_53_Firmicutes;Clostridiales;Lachnospiraceae 0.6899 0.4406 0.2639 1.5177 0.7840 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0031 OTU_55_Bacteroidetes;Bacteroidales 1.0415 0.6155 0.2639 2.0267 0.9544 0.0836 0.041554829 0.0267 0.1464 0.0795 0.0030 OTU_61_Firmicutes;Clostridiales 0.3371 0.1372 0.2287 0.6164 0.2726 0.1521 0.162836031 0.0200 0.4119 0.0903 0.0478 OTU_66_Firmicutes;Clostridiales;Lachnospiraceae;Anaerostipes 0.0197 0.0272 0.0068 0.0805 0.0071 0.4221 0.360092673 0.0868 1.0870 0.3114 0.0128 OTU_68_Firmicutes;Clostridiales;Lachnospiraceae 0.0407 0.0529 0.0067 0.1594 0.0205 0.4237 0.424383198 0.0401 0.8882 0.3448 0.0362 OTU_69_Bacteroidetes;Bacteroidales;Bacteroidaceae;Bacteroides acidifaciens 0.0073 0.0011 0.0067 0.0097 0.0068 0.2483 0.118047212 0.1002 0.4022 0.2434 0.0002 OTU_70_Firmicutes;Clostridiales 0.1604 0.0651 0.0947 0.2772 0.1476 0.5289 0.368624201 0.0665 0.9351 0.5468 0.0240 OTU_74_Firmicutes;Clostridiales;Lachnospiraceae 0.0694 0.1059 0.0068 0.2824 0.0135 0.2046 0.094446285 0.0865 0.3327 0.2283 0.0346 OTU_75_Firmicutes;Clostridiales 0.0965 0.1178 0.0069 0.2913 0.0389 0.5081 0.328492696 0.0815 0.8651 0.5322 0.0099 OTU_76_Firmicutes;Clostridiales;Lachnospiraceae 0.0240 0.0090 0.0097 0.0356 0.0205 0.2844 0.19131736 0.0068 0.5523 0.2989 0.0040 OTU_78_Actinobacteria;Coriobacteriales;Coriobacteriaceae;Adlercreutzia 0.2487 0.1348 0.0762 0.4606 0.2434 0.1083 0.059078233 0.0200 0.1927 0.1043 0.0381 OTU_79_Firmicutes;Clostridiales 0.1772 0.0990 0.0624 0.3315 0.1779 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0015 OTU_8_Firmicutes;Clostridiales 5.3898 3.9333 1.3907 12.8344 5.5404 0.0081 0.002723633 0.0067 0.0135 0.0067 0.0067 OTU_80_Firmicutes;Clostridiales 0.0565 0.0642 0.0068 0.1626 0.0292 1.2206 1.26016466 0.1603 3.4704 0.8815 0.0317 OTU_81_Firmicutes;Lactobacillales;Streptococcaceae;Lactococcus garvieae 0.0073 0.0011 0.0067 0.0097 0.0068 0.3592 0.253071653 0.0067 0.6787 0.3694 0.0035 OTU_82_Actinobacteria;Coriobacteriales;Coriobacteriaceae;Adlercreutzia 0.1356 0.0854 0.0271 0.2434 0.1386 0.0346 0.040208014 0.0067 0.1137 0.0236 0.0228 OTU_86_Firmicutes;Clostridiales;Lachnospiraceae 0.5932 0.4929 0.0068 1.2613 0.5570 0.0070 0.00068225 0.0067 0.0084 0.0067 0.0146 OTU_89_Actinobacteria;Coriobacteriales;Coriobacteriaceae;Adlercreutzia 0.0307 0.0417 0.0067 0.1150 0.0069 0.1136 0.055501743 0.0466 0.1873 0.1246 0.0105 OTU_93_Firmicutes;Clostridiales;Ruminococcaceae;Ruminococcus 0.4989 0.3142 0.2483 1.0949 0.3590 0.0748 0.040456188 0.0251 0.1485 0.0700 0.0075 OTU_96_Bacteroidetes;Bacteroidales;Rikenellaceae 0.0082 0.0026 0.0067 0.0135 0.0069 0.1354 0.095428122 0.0401 0.2633 0.1114 0.0045