This PDF file includes:

• Fig. S1. Expected and observed numbers of 8-week-old offspring with specified Trib1 genotypes.
• Fig. S2. Trib1^mKO and Trib1^mTg mice have normal tissue anatomy and F4/80⁺ macrophage numbers.
• Fig. S3. Plasma lipid levels of chimera and Pcsk9 mice.
• Fig. S4. Atherosclerotic burden in mTrib1➔ApoE^−/− mice, clinical grading of lesions, and presence of foam cells.
• Fig. S5. Reciprocal regulation of OLR1 and SCARB1 RNA levels in polarized MDMs.
• Table S1. Fold changes and P values of genes differentially expressed in both MDMs and monocytes.
• Table S2. Top-ranking biological processes enriched in differentially expressed gene lists of (1) Human TRIB1^High versus TRIB1^Low monocytes and (2) between TRIB1^High versus TRIB1^Low MDMs.
• Table S3. The most significantly altered pathways in TRIB1^High versus TRIB1^Low macrophages.
• Table S4. Linoleic (LiA), oleic (OA), and lauric acid (LA) in vitro polarized human MDMs recapitulate the Olr1^High/Lpl^High/Scarb1^Low/CD36^WT RNA profile of Trib1^mTg BMDM.
• Table S5. Primer sequences.

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