This PDF file includes:

• Fig. S1. Mito-SN38 does not trap nuclear-Top1cc but impairs mitochondrial metabolism through SCAN1-TDP1 trapping in the mitochondria.
• Fig. S2. Differentiation of SH-SY5Y cells showing expression of FLAG-TDP1 and lysosomal localization of SCAN1 mitochondria showing mitophagy.
• Table S1. List of primers used.

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