The PDFset includes:

• Fig. S1. Synthetic pathways of DOX-hyd-BSA.
• Fig. S2. ¹H NMR analysis.
• Fig. S3. TEM images of BSA NPs and DOX-ab-BSA NPs.
• Fig. S4. The stability of BSA NPs in serum.
• Fig. S5. Quantitative analysis of cellular uptake of DOX by differentiated HL-60 cells.
• Fig. S6. Flow cytometric analysis on apoptosis of differentiated HL-60 cells 24 hours after treatments with free DOX (0.2 mg/kg), DOX-ab-BSA, or DOX-hyd-BSA NPs (equal to DOX of 0.2 mg/kg), respectively.
• Fig. S7. Flow cytometric analysis of neutrophils in BALF.
• Fig. S8. DOX-hyd-BSA NPs decrease systemic inflammation in the mouse sepsis model.
• Fig. S9. Mouse body weights were monitored following the experiment as shown in Fig. 5M.
• Fig. S10. Toxicity of DOX-conjugated BSA NPs evaluated by histological analysis.

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Other Supplementary Material for this manuscript includes the following:

• Movie S1 (.mp4 format). Intravital microscopy of a cremaster venule shows resting neutrophils in circulation.
• Movie S2 (.mp4 format). Intravital microscopy of a cremaster venule shows activated neutrophils in circulation.
• Movie S3 (.mp4 format). Movement of a sham mouse in the cerebral I/R model.
• Movie S4 (.mp4 format). Movement of a mouse with cerebral I/R after PBS treatment.
• Movie S5 (.mp4 format). Movement of a mouse with cerebral I/R after DOX treatment.
• Movie S6 (.mp4 format). Movement of a mouse with cerebral I/R after treatment of DOX-hyd-BSA NPs.