Cluster ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count Control_CD40LG R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 15/137 243/10554 5.61181482850867e-07 0.000303599182222319 0.000227426179892193 23283/8926/9631/53981/5435/23511/2962/23279/9879/5356/23165/29107/84991/22826/10465 15 Control_CD40LG R-HSA-6784531 tRNA processing in the nucleus 7/137 56/10554 7.26851143245888e-06 0.00164097756071934 0.00122925646634292 1653/9631/23511/51367/51095/23279/23165 7 Control_CD40LG R-HSA-72306 tRNA processing 9/137 106/10554 9.09969072487618e-06 0.00164097756071934 0.00122925646634292 1653/9631/23511/51367/51095/23279/23165/9836/112858 9 Control_CD40LG R-HSA-168325 Viral Messenger RNA Synthesis 6/137 42/10554 1.53164218560149e-05 0.00207154605602601 0.00155179537225414 9631/5435/23511/2962/23279/23165 6 Control_CD40LG R-HSA-6782135 Dual incision in TC-NER 7/137 66/10554 2.19124552947202e-05 0.00237092766288873 0.00177606216599312 2073/6118/5435/3150/54107/5981/2068 7 Control_CD40LG R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 7/137 79/10554 7.09037341518314e-05 0.00578374447065063 0.00433260360190776 2073/6118/5435/3150/54107/5981/2068 7 Control_CD40LG R-HSA-162599 Late Phase of HIV Life Cycle 9/137 138/10554 7.48358803965886e-05 0.00578374447065063 0.00433260360190776 9631/5435/23511/2962/23279/23165/9397/11198/2068 9 Control_CD40LG R-HSA-72163 mRNA Splicing - Major Pathway 10/137 183/10554 0.00013146437523663 0.00681245449138101 0.00510321038852357 23283/8926/53981/5435/2962/9879/5356/84991/22826/10465 10 Control_CD40LG R-HSA-162587 HIV Life Cycle 9/137 151/10554 0.000149444746539047 0.00681245449138101 0.00510321038852357 9631/5435/23511/2962/23279/23165/9397/11198/2068 9 Control_CD40LG R-HSA-69239 Synthesis of DNA 8/137 119/10554 0.000153614411245164 0.00681245449138101 0.00510321038852357 6118/8454/246184/54107/7324/5981/5721/4172 8 Control_CD40LG R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 5/137 40/10554 0.000156456973860131 0.00681245449138101 0.00510321038852357 9631/53981/23511/23279/23165 5 Control_CD40LG R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 5/137 41/10554 0.000176344210940077 0.00681245449138101 0.00510321038852357 9631/53981/23511/23279/23165 5 Control_CD40LG R-HSA-5696400 Dual Incision in GG-NER 5/137 41/10554 0.000176344210940077 0.00681245449138101 0.00510321038852357 2073/6118/54107/5981/2068 5 Control_CD40LG R-HSA-72172 mRNA Splicing 10/137 191/10554 0.000186707656391495 0.00681245449138101 0.00510321038852357 23283/8926/53981/5435/2962/9879/5356/84991/22826/10465 10 Control_CD40LG R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 6/137 65/10554 0.000188885059834963 0.00681245449138101 0.00510321038852357 6118/5435/3150/54107/5981/2068 6 Control_CD40LG R-HSA-69306 DNA Replication 8/137 127/10554 0.000240724844094637 0.00788300172499448 0.00590515743578728 6118/8454/246184/54107/7324/5981/5721/4172 8 Control_CD40LG R-HSA-4615885 SUMOylation of DNA replication proteins 5/137 44/10554 0.00024770985087783 0.00788300172499448 0.00590515743578728 9631/7155/23511/23279/23165 5 Control_CD40LG R-HSA-191859 snRNP Assembly 5/137 52/10554 0.000545579328300833 0.0138567950616408 0.0103801266635504 9631/23511/23279/23165/50628 5 Control_CD40LG R-HSA-194441 Metabolism of non-coding RNA 5/137 52/10554 0.000545579328300833 0.0138567950616408 0.0103801266635504 9631/23511/23279/23165/50628 5 Control_CD40LG R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 4/137 30/10554 0.000573004639490679 0.0138567950616408 0.0103801266635504 9631/23511/23279/23165 4 Control_CD40LG R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 4/137 30/10554 0.000573004639490679 0.0138567950616408 0.0103801266635504 9631/23511/23279/23165 4 Control_CD40LG R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 4/137 30/10554 0.000573004639490679 0.0138567950616408 0.0103801266635504 9631/23511/23279/23165 4 Control_CD40LG R-HSA-5696398 Nucleotide Excision Repair 7/137 111/10554 0.000589105889866431 0.0138567950616408 0.0103801266635504 2073/6118/5435/3150/54107/5981/2068 7 Control_CD40LG R-HSA-72202 Transport of Mature Transcript to Cytoplasm 6/137 83/10554 0.000713387392480435 0.0147659505471712 0.0110611751350538 9631/53981/23511/23279/23165/29107 6 Control_CD40LG R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 4/137 32/10554 0.00073693283691982 0.0147659505471712 0.0110611751350538 9631/23511/23279/23165 4 Control_CD40LG R-HSA-180746 Nuclear import of Rev protein 4/137 32/10554 0.00073693283691982 0.0147659505471712 0.0110611751350538 9631/23511/23279/23165 4 Control_CD40LG R-HSA-180910 Vpr-mediated nuclear import of PICs 4/137 32/10554 0.00073693283691982 0.0147659505471712 0.0110611751350538 9631/23511/23279/23165 4 Control_CD40LG R-HSA-159227 Transport of the SLBP independent Mature mRNA 4/137 33/10554 0.000830206802771462 0.0149713960099787 0.0112150743532285 9631/23511/23279/23165 4 Control_CD40LG R-HSA-165054 Rev-mediated nuclear export of HIV RNA 4/137 33/10554 0.000830206802771462 0.0149713960099787 0.0112150743532285 9631/23511/23279/23165 4 Control_CD40LG R-HSA-4085377 SUMOylation of SUMOylation proteins 4/137 33/10554 0.000830206802771462 0.0149713960099787 0.0112150743532285 9631/23511/23279/23165 4 Control_CD40LG R-HSA-162906 HIV Infection 10/137 232/10554 0.000869605512549651 0.0151760187835278 0.0113683572947917 9631/5435/23511/2962/23279/23165/9397/5721/11198/2068 10 Control_CD40LG R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 4/137 34/10554 0.000931511141997158 0.0152711372066807 0.0114396105157546 9631/23511/23279/23165 4 Control_CD40LG R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 4/137 34/10554 0.000931511141997158 0.0152711372066807 0.0114396105157546 9631/23511/23279/23165 4 Control_CD40LG R-HSA-176033 Interactions of Vpr with host cellular proteins 4/137 35/10554 0.00104121443474911 0.0160942002628363 0.0120561671392003 9631/23511/23279/23165 4 Control_CD40LG R-HSA-177243 Interactions of Rev with host cellular proteins 4/137 35/10554 0.00104121443474911 0.0160942002628363 0.0120561671392003 9631/23511/23279/23165 4 Control_CD40LG R-HSA-112382 Formation of RNA Pol II elongation complex 5/137 61/10554 0.00113774340196067 0.0166062625773796 0.0124397530738226 5435/2962/123169/11198/2068 5 Control_CD40LG R-HSA-75955 RNA Polymerase II Transcription Elongation 5/137 61/10554 0.00113774340196067 0.0166062625773796 0.0124397530738226 5435/2962/123169/11198/2068 5 Control_CD40LG R-HSA-69242 S Phase 8/137 161/10554 0.00116642879471428 0.0166062625773796 0.0124397530738226 6118/8454/246184/54107/7324/5981/5721/4172 8 Control_CD40LG R-HSA-3232142 SUMOylation of ubiquitinylation proteins 4/137 37/10554 0.00128729201165487 0.0178570507257766 0.0133767186096391 9631/23511/23279/23165 4 Control_CD40LG R-HSA-168276 NS1 Mediated Effects on Host Pathways 4/137 39/10554 0.00157138155726387 0.0212529355619939 0.0159205763038576 9631/23511/23279/23165 4 Control_CD40LG R-HSA-168273 Influenza Viral RNA Transcription and Replication 7/137 133/10554 0.00170504385570233 0.0224982616081697 0.0168534501783157 9631/5435/23511/2962/23279/6146/23165 7 Control_CD40LG R-HSA-3371453 Regulation of HSF1-mediated heat shock response 5/137 68/10554 0.00185447556062097 0.0238594378956099 0.0178731074809025 9631/6118/23511/23279/23165 5 Control_CD40LG R-HSA-168253 Host Interactions with Influenza Factors 4/137 41/10554 0.00189640633920744 0.0238594378956099 0.0178731074809025 9631/23511/23279/23165 4 Control_CD40LG R-HSA-4551638 SUMOylation of chromatin organization proteins 5/137 70/10554 0.00210917283366553 0.0253569445114012 0.0189948898470463 9631/23511/23279/23165/3065 5 Control_CD40LG R-HSA-70171 Glycolysis 5/137 70/10554 0.00210917283366553 0.0253569445114012 0.0189948898470463 9631/23511/23279/132789/23165 5 Control_CD40LG R-HSA-1169408 ISG15 antiviral mechanism 5/137 71/10554 0.00224567585006723 0.0264111007583994 0.0197845584044825 9631/23511/23279/23165/7324 5 Control_CD40LG R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 3/137 21/10554 0.0023980924771553 0.0276035751093833 0.0206778410684164 6118/54107/5981 3 Control_CD40LG R-HSA-168255 Influenza Life Cycle 7/137 143/10554 0.00257457800766848 0.0290176396280969 0.0217371169507098 9631/5435/23511/2962/23279/6146/23165 7 Control_CD40LG R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 5/137 74/10554 0.0026938306012618 0.0296727292228094 0.0222278446362129 9631/23511/23279/23165/29107 5 Control_CD40LG R-HSA-167169 HIV Transcription Elongation 4/137 46/10554 0.0029069402011255 0.0296727292228094 0.0222278446362129 5435/2962/11198/2068 4 Control_CD40LG R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 4/137 46/10554 0.0029069402011255 0.0296727292228094 0.0222278446362129 5435/2962/11198/2068 4 Control_CD40LG R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 4/137 46/10554 0.0029069402011255 0.0296727292228094 0.0222278446362129 5435/2962/11198/2068 4 Control_CD40LG R-HSA-4570464 SUMOylation of RNA binding proteins 4/137 46/10554 0.0029069402011255 0.0296727292228094 0.0222278446362129 9631/23511/23279/23165 4 Control_CD40LG R-HSA-2990846 SUMOylation 8/137 187/10554 0.00299216157143507 0.0299770261138217 0.0224557934698343 9631/7155/23511/23279/23165/1786/3065/10055 8 Control_CD40LG R-HSA-73762 RNA Polymerase I Transcription Initiation 4/137 47/10554 0.0031458045238789 0.0309432772257906 0.023179612281213 5435/57459/3065/2068 4 Control_CD40LG R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 5/137 78/10554 0.00338788182660527 0.0322485857132084 0.0241574190088243 9631/23511/23279/23165/7324 5 Control_CD40LG R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 4/137 48/10554 0.00339772529695541 0.0322485857132084 0.0241574190088243 5435/2962/11198/2068 4 Control_CD40LG R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 3/137 24/10554 0.00354726140210303 0.0330873865265127 0.0247857647878342 6118/54107/5981 3 Control_CD40LG R-HSA-168254 Influenza Infection 7/137 154/10554 0.00388834924035189 0.0356541854072944 0.026708554104112 9631/5435/23511/2962/23279/6146/23165 7 Control_CD40LG R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 3/137 25/10554 0.00399305203842391 0.0360040192131223 0.0269706146454949 6118/54107/5981 3 Control_CD40LG R-HSA-2980766 Nuclear Envelope Breakdown 4/137 51/10554 0.00423516864706581 0.0375610858698788 0.0281370134446995 9631/23511/23279/23165 4 Control_CD40LG R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 3/137 26/10554 0.00447144026478793 0.0390169223104882 0.0292275806781554 6118/54107/5981 3 Control_CD40LG R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 5/137 84/10554 0.00465784605568076 0.0393733549394264 0.0294945843986364 2073/6118/54107/5981/2068 5 Control_CD40LG R-HSA-674695 RNA Polymerase II Pre-transcription Events 5/137 84/10554 0.00465784605568076 0.0393733549394264 0.0294945843986364 5435/2962/123169/11198/2068 5 Control_CD40LG R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 3/137 27/10554 0.00498309785979455 0.0408463021537705 0.030597969314528 5435/2962/2068 3 Control_CD40LG R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 3/137 27/10554 0.00498309785979455 0.0408463021537705 0.030597969314528 5435/2962/2068 3 Control_CD40LG R-HSA-3371556 Cellular response to heat stress 5/137 88/10554 0.00567281183695871 0.0458058388626069 0.0343131587938587 9631/6118/23511/23279/23165 5 Control_CD40LG R-HSA-72086 mRNA Capping 3/137 29/10554 0.00610869671333533 0.0481859263526446 0.0360960825873493 5435/2962/2068 3 Control_CD40LG R-HSA-69052 Switching of origins to a post-replicative state 5/137 90/10554 0.00623477790145124 0.0481859263526446 0.0360960825873493 8454/246184/7324/5721/4172 5 Control_CD40LG R-HSA-70326 Glucose metabolism 5/137 90/10554 0.00623477790145124 0.0481859263526446 0.0360960825873493 9631/23511/23279/132789/23165 5 Control_GBP2 R-HSA-6798695 Neutrophil degranulation 10/50 479/10554 6.741856168268e-05 0.0171917332290834 0.0148320835701896 5799/25797/3920/4318/5580/6386/6515/3837/26578/9545 10 Control_GBP2 R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 5/50 123/10554 0.000276028164090935 0.0351935909215942 0.0303630980500028 55788/54625/6515/83666/80025 5 Control_GBP2 R-HSA-2871796 FCERI mediated MAPK activation 3/50 32/10554 0.000450507515787841 0.0361919934179803 0.0312244649096301 3937/5062/6416 3 Control_GBP2 R-HSA-168898 Toll-like Receptor Cascades 5/50 155/10554 0.000796586326060035 0.0361919934179803 0.0312244649096301 29110/5515/6416/57162/51311 5 Control_GBP2 R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 4/50 93/10554 0.000954536513787155 0.0361919934179803 0.0312244649096301 5515/6416/57162/51311 4 Control_GBP2 R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 4/50 94/10554 0.000993505701670047 0.0361919934179803 0.0312244649096301 5515/6416/57162/51311 4 Control_GBP2 R-HSA-975155 MyD88 dependent cascade initiated on endosome 4/50 94/10554 0.000993505701670047 0.0361919934179803 0.0312244649096301 5515/6416/57162/51311 4 Control_GBP2 R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 4/50 98/10554 0.00116063088749096 0.0369951095387744 0.0319173494060014 5515/6416/57162/51311 4 Control_GBP2 R-HSA-449147 Signaling by Interleukins 8/50 462/10554 0.00134746312009238 0.0381781217359509 0.0329379873800361 29110/5515/4318/5062/6416/57162/3570/3597 8 Control_GBP2 R-HSA-75153 Apoptotic execution phase 3/50 52/10554 0.00187808830534559 0.0446517883210657 0.0385231114926841 5062/5580/3837 3 Control_GBP2 R-HSA-196854 Metabolism of vitamins and cofactors 5/50 189/10554 0.0019261555746342 0.0446517883210657 0.0385231114926841 55788/54625/6515/83666/80025 5 Control_GBP2 R-HSA-913531 Interferon Signaling 5/50 197/10554 0.0023086632686488 0.0490590944587871 0.0423254932585614 5580/8638/3837/51191/3430 5 HAM_CD40LG R-HSA-4615885 SUMOylation of DNA replication proteins 7/221 44/10554 3.18214394157001e-05 0.0187110063764317 0.017686021064726 23165/3619/23225/10401/9631/7155/5905 7 HAM_GBP2 R-HSA-909733 Interferon alpha/beta signaling 6/20 69/10554 2.256144194718e-09 3.7226379212847e-07 3.13485298634501e-07 8519/3437/6772/10410/3433/6773 6 HAM_GBP2 R-HSA-913531 Interferon Signaling 7/20 197/10554 4.47919644922771e-08 3.69533707061286e-06 3.11186279630557e-06 8519/3437/6772/10410/9246/3433/6773 7 HAM_GBP2 R-HSA-1296041 Activation of G protein gated Potassium channels 2/20 25/10554 0.000997137048125473 0.0254336980297632 0.0214178509724322 3772/94235 2 HAM_GBP2 R-HSA-1296059 G protein gated Potassium channels 2/20 25/10554 0.000997137048125473 0.0254336980297632 0.0214178509724322 3772/94235 2 HAM_GBP2 R-HSA-8854691 Interleukin-20 family signaling 2/20 25/10554 0.000997137048125473 0.0254336980297632 0.0214178509724322 6772/6773 2 HAM_GBP2 R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 2/20 25/10554 0.000997137048125473 0.0254336980297632 0.0214178509724322 3772/94235 2 HAM_GBP2 R-HSA-912694 Regulation of IFNA signaling 2/20 26/10554 0.00107900537095965 0.0254336980297632 0.0214178509724322 6772/6773 2 HAM_GBP2 R-HSA-1296065 Inwardly rectifying K+ channels 2/20 31/10554 0.00153506573617984 0.0316607308087091 0.0266616680494393 3772/94235 2 HAM_GBP2 R-HSA-977444 GABA B receptor activation 2/20 39/10554 0.00242408679352141 0.0399974320931033 0.0336820480784028 3772/94235 2 HAM_GBP2 R-HSA-991365 Activation of GABAB receptors 2/20 39/10554 0.00242408679352141 0.0399974320931033 0.0336820480784028 3772/94235 2 ATL_GBP2 R-HSA-162906 HIV Infection 37/449 232/10554 2.42579542175013e-12 1.95033951908711e-09 1.28950177682507e-09 5698/5721/6884/5689/6883/5437/9978/5696/23165/5439/5435/3932/9525/3981/5436/5715/5686/2958/9972/5711/9688/5718/5441/6827/7514/137492/6880/5695/4928/5062/5684/5688/5690/6879/7175/5705/10213 37 ATL_GBP2 R-HSA-1236974 ER-Phagosome pathway 21/449 83/10554 2.1499457067258e-11 8.64278174103772e-09 5.71432937840279e-09 4615/5698/5721/5689/6891/6890/5696/10952/8673/23480/5715/5686/5711/5718/9341/5695/5684/5688/5690/5705/10213 21 ATL_GBP2 R-HSA-1236975 Antigen processing-Cross presentation 21/449 99/10554 7.50600748217964e-10 1.52682874757593e-07 1.00949007269683e-07 4615/5698/5721/5689/6891/6890/5696/10952/8673/23480/5715/5686/5711/5718/9341/5695/5684/5688/5690/5705/10213 21 ATL_GBP2 R-HSA-5689880 Ub-specific processing proteases 32/449 220/10554 8.80725732769035e-10 1.52682874757593e-07 1.00949007269683e-07 3416/5698/5721/5689/84196/5696/9101/55031/23358/6478/3017/5715/8345/85236/5686/8347/57695/5711/8970/55611/5718/7186/10869/8339/5695/10254/7416/5684/5688/5690/5705/10213 32 ATL_GBP2 R-HSA-5688426 Deubiquitination 38/449 297/10554 9.87117679922487e-10 1.52682874757593e-07 1.00949007269683e-07 3416/5698/5721/5689/10392/84196/5696/9101/84282/51377/55031/23358/4738/6478/7347/3017/5715/8345/85236/5686/8347/8027/57695/5711/8970/55611/5718/7186/10869/8339/5695/10254/7416/5684/5688/5690/5705/10213 38 ATL_GBP2 R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 15/449 50/10554 1.226782038562e-09 1.52682874757593e-07 1.00949007269683e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5062/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-5663205 Infectious disease 44/449 382/10554 1.32932851157108e-09 1.52682874757593e-07 1.00949007269683e-07 5698/5721/6884/51065/5689/6883/5437/9978/5696/23165/5439/5435/3932/9525/9045/3981/5436/5715/5686/2958/9636/8027/9972/5711/9688/5718/116832/5441/51121/6827/7514/137492/6880/5695/10254/4928/5062/5684/5688/5690/6879/7175/5705/10213 44 ATL_GBP2 R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 15/449 51/10554 1.67103652953596e-09 1.67939171218364e-07 1.11035979923113e-07 5698/5721/5689/5696/5715/5686/5711/5718/4946/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-169911 Regulation of Apoptosis 15/449 53/10554 3.02821431558107e-09 2.493356626906e-07 1.648527227792e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5062/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-162909 Host Interactions of HIV factors 23/449 128/10554 3.63208390048881e-09 2.493356626906e-07 1.648527227792e-07 5698/5721/5689/9978/5696/23165/3932/5715/5686/9972/5711/9688/5718/7514/5695/4928/5062/5684/5688/5690/7175/5705/10213 23 ATL_GBP2 R-HSA-180585 Vif-mediated degradation of APOBEC3G 15/449 54/10554 4.03154678479826e-09 2.493356626906e-07 1.648527227792e-07 5698/5721/5689/9978/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 15/449 54/10554 4.03154678479826e-09 2.493356626906e-07 1.648527227792e-07 5698/5721/5689/9978/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-9604323 Negative regulation of NOTCH4 signaling 15/449 54/10554 4.03154678479826e-09 2.493356626906e-07 1.648527227792e-07 5698/5721/5689/9978/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-4641258 Degradation of DVL 15/449 57/10554 9.13444957374377e-09 5.20331703970199e-07 3.44026591391661e-07 5698/5721/5689/9978/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 16/449 66/10554 1.06128008754898e-08 5.20331703970199e-07 3.44026591391661e-07 5698/5721/5689/9978/5696/5715/7323/5686/5711/5718/5695/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen 17/449 75/10554 1.10020385167828e-08 5.20331703970199e-07 3.44026591391661e-07 5698/5721/5689/9978/5696/5715/7323/25994/5686/5711/5718/5695/5684/5688/5690/5705/10213 17 ATL_GBP2 R-HSA-2262749 Cellular response to hypoxia 17/449 75/10554 1.10020385167828e-08 5.20331703970199e-07 3.44026591391661e-07 5698/5721/5689/9978/5696/5715/7323/25994/5686/5711/5718/5695/5684/5688/5690/5705/10213 17 ATL_GBP2 R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 14/449 50/10554 1.19542514022185e-08 5.33956562632427e-07 3.53034909831599e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-5610780 Degradation of GLI1 by the proteasome 15/449 60/10554 1.95827731729657e-08 6.52363469755373e-07 4.31321749445488e-07 5698/5721/5689/9978/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-5610783 Degradation of GLI2 by the proteasome 15/449 60/10554 1.95827731729657e-08 6.52363469755373e-07 4.31321749445488e-07 5698/5721/5689/9978/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 15/449 60/10554 1.95827731729657e-08 6.52363469755373e-07 4.31321749445488e-07 5698/5721/5689/9978/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-180534 Vpu mediated degradation of CD4 14/449 52/10554 2.08509762375389e-08 6.52363469755373e-07 4.31321749445488e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 14/449 52/10554 2.08509762375389e-08 6.52363469755373e-07 4.31321749445488e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1 14/449 52/10554 2.08509762375389e-08 6.52363469755373e-07 4.31321749445488e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 14/449 52/10554 2.08509762375389e-08 6.52363469755373e-07 4.31321749445488e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-8948751 Regulation of PTEN stability and activity 16/449 69/10554 2.10963311114922e-08 6.52363469755373e-07 4.31321749445488e-07 5698/5721/23608/5689/5696/4734/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-202403 TCR signaling 21/449 119/10554 2.44281091878839e-08 7.27414806928099e-07 4.80943280307266e-07 5698/4690/5721/5689/5795/5696/5291/3932/5715/5686/5711/5718/27040/5695/10892/5062/5684/5688/5690/5705/10213 21 ATL_GBP2 R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 14/449 53/10554 2.72488907736265e-08 7.3027027273319e-07 4.82831222480048e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-69610 p53-Independent DNA Damage Response 14/449 53/10554 2.72488907736265e-08 7.3027027273319e-07 4.82831222480048e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-69613 p53-Independent G1/S DNA damage checkpoint 14/449 53/10554 2.72488907736265e-08 7.3027027273319e-07 4.82831222480048e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-68949 Orc1 removal from chromatin 16/449 71/10554 3.26344869618618e-08 8.46391210236674e-07 5.59606652486935e-07 5698/5721/5689/9978/5696/5715/5686/5711/5718/4175/5695/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-195253 Degradation of beta-catenin by the destruction complex 17/449 82/10554 4.5610905274274e-08 1.01916370685583e-06 6.73838271749401e-07 5698/5721/5689/9978/5696/5715/5686/5519/5711/5718/5525/5695/5684/5688/5690/5705/10213 17 ATL_GBP2 R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 14/449 55/10554 4.56341958293654e-08 1.01916370685583e-06 6.73838271749401e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-4641257 Degradation of AXIN 14/449 55/10554 4.56341958293654e-08 1.01916370685583e-06 6.73838271749401e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-6799198 Complex I biogenesis 14/449 55/10554 4.56341958293654e-08 1.01916370685583e-06 6.73838271749401e-07 4716/4708/4701/4709/4694/55967/126328/4712/4717/51103/4714/4713/4731/4711 14 ATL_GBP2 R-HSA-8941858 Regulation of RUNX3 expression and activity 14/449 55/10554 4.56341958293654e-08 1.01916370685583e-06 6.73838271749401e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-8939902 Regulation of RUNX2 expression and activity 16/449 73/10554 4.96758585029385e-08 1.06682228062274e-06 7.0534858826196e-07 5698/5721/5689/9978/5696/5715/5686/5711/5718/11059/5695/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-983169 Class I MHC mediated antigen processing & presentation 40/449 371/10554 5.0421948586647e-08 1.06682228062274e-06 7.0534858826196e-07 4615/9690/5698/5721/200845/23608/5689/6891/6890/7174/92912/9354/9978/5696/9616/10484/10427/10952/8673/23480/9604/6478/7320/4734/5715/7323/7332/5686/5711/5718/4591/9320/9341/11059/5695/5684/5688/5690/5705/10213 40 ATL_GBP2 R-HSA-9020702 Interleukin-1 signaling 19/449 103/10554 5.44545004946163e-08 1.12260047173517e-06 7.42227334676956e-07 4615/5698/11213/5721/5689/10392/9978/1326/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 19 ATL_GBP2 R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 14/449 56/10554 5.85122739429468e-08 1.14741142073486e-06 7.58631536359131e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 14/449 56/10554 5.85122739429468e-08 1.14741142073486e-06 7.58631536359131e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-69541 Stabilization of p53 14/449 57/10554 7.4588774900362e-08 1.42686121279797e-06 9.43394753159168e-07 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-69563 p53-Dependent G1 DNA Damage Response 15/449 66/10554 7.80869320436697e-08 1.42686121279797e-06 9.43394753159168e-07 5698/57060/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 15/449 66/10554 7.80869320436697e-08 1.42686121279797e-06 9.43394753159168e-07 5698/57060/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-1169091 Activation of NF-kappaB in B cells 15/449 67/10554 9.67452039908632e-08 1.72851431130342e-06 1.14283808223125e-06 5698/5721/5689/5696/5715/5686/5711/5718/5695/10892/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-5387390 Hh mutants abrogate ligand secretion 14/449 59/10554 1.19216217976627e-07 1.85224129023415e-06 1.22464238225745e-06 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-5676590 NIK-->noncanonical NF-kB signaling 14/449 59/10554 1.19216217976627e-07 1.85224129023415e-06 1.22464238225745e-06 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex 14/449 59/10554 1.19216217976627e-07 1.85224129023415e-06 1.22464238225745e-06 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-5658442 Regulation of RAS by GAPs 15/449 68/10554 1.19355943483793e-07 1.85224129023415e-06 1.22464238225745e-06 5698/5721/5689/9978/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-68867 Assembly of the pre-replicative complex 15/449 68/10554 1.19355943483793e-07 1.85224129023415e-06 1.22464238225745e-06 5698/5721/5689/5696/5715/5686/5711/5718/4175/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-69615 G1/S DNA Damage Checkpoints 15/449 68/10554 1.19355943483793e-07 1.85224129023415e-06 1.22464238225745e-06 5698/57060/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 21/449 130/10554 1.19796700363402e-07 1.85224129023415e-06 1.22464238225745e-06 5698/5721/5689/5696/3017/5715/8345/85236/5686/8347/5711/8970/5718/8339/5695/5684/5688/5690/5705/10213/6688 21 ATL_GBP2 R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 14/449 60/10554 1.49539440308176e-07 2.22647611125506e-06 1.47207441239042e-06 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 14/449 60/10554 1.49539440308176e-07 2.22647611125506e-06 1.47207441239042e-06 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-69481 G2/M Checkpoints 24/449 168/10554 1.67064196953913e-07 2.44217480638084e-06 1.61468745381294e-06 5698/5721/5689/5696/10111/3017/5715/5932/8345/85236/5686/8347/5711/8970/5718/4175/8339/5695/5684/5688/5690/7158/5705/10213 24 ATL_GBP2 R-HSA-5678895 Defective CFTR causes cystic fibrosis 14/449 61/10554 1.86645299392766e-07 2.64344958314667e-06 1.74776386421716e-06 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-69275 G2/M Transition 26/449 194/10554 1.87408739103682e-07 2.64344958314667e-06 1.74776386421716e-06 5698/10133/5721/5689/9978/5696/4659/5500/5928/5108/5715/5686/5519/5711/8481/5718/7514/4218/121441/5695/5684/5688/5690/5520/5705/10213 26 ATL_GBP2 R-HSA-453274 Mitotic G2-G2/M phases 26/449 196/10554 2.30336020586007e-07 3.19293380260603e-06 2.1110651614507e-06 5698/10133/5721/5689/9978/5696/4659/5500/5928/5108/5715/5686/5519/5711/8481/5718/7514/4218/121441/5695/5684/5688/5690/5520/5705/10213 26 ATL_GBP2 R-HSA-68886 M Phase 40/449 393/10554 2.40491263096931e-07 3.27720297508361e-06 2.16678122861642e-06 5698/5721/5689/5696/23165/5861/5108/81565/6418/3017/5715/7444/8345/85236/5686/8347/5519/84930/9972/5711/8970/9688/8481/5718/5525/7514/8339/4001/121441/5695/5925/8379/4928/5684/5688/5690/7175/5520/5705/10213 40 ATL_GBP2 R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 14/449 63/10554 2.86667015639139e-07 3.84133800956446e-06 2.539769173645e-06 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-69202 Cyclin E associated events during G1/S transition 16/449 83/10554 3.29005875111679e-07 4.33640530475066e-06 2.86709175032611e-06 5698/5721/5689/5696/5928/5715/5686/5711/5718/5695/5925/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-4608870 Asymmetric localization of PCP proteins 14/449 64/10554 3.52877649784963e-07 4.57602629721146e-06 3.02552144552473e-06 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-446652 Interleukin-1 family signaling 21/449 139/10554 3.84769368645172e-07 4.91039003794791e-06 3.24659199942877e-06 4615/5698/11213/29110/5721/5689/10392/9978/1326/5696/5715/5686/5771/5711/5718/5695/5684/5688/5690/5705/10213 21 ATL_GBP2 R-HSA-5358346 Hedgehog ligand biogenesis 14/449 65/10554 4.32520011858128e-07 5.43353264896774e-06 3.59247707217689e-06 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-5632684 Hedgehog 'on' state 16/449 85/10554 4.62870686751788e-07 5.6386065477036e-06 3.72806533986687e-06 5698/5721/5689/9978/5696/25989/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 16/449 85/10554 4.62870686751788e-07 5.6386065477036e-06 3.72806533986687e-06 5698/5721/5689/5696/5928/5715/5686/5711/5718/5695/5925/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 14/449 67/10554 6.41845951260645e-07 7.70215141512774e-06 5.09241485289278e-06 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-202424 Downstream TCR signaling 17/449 98/10554 6.85908983016246e-07 8.1098650344862e-06 5.3619819879753e-06 5698/5721/5689/5696/5291/3932/5715/5686/5711/5718/5695/10892/5684/5688/5690/5705/10213 17 ATL_GBP2 R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 16/449 88/10554 7.57108536370864e-07 8.82196033684311e-06 5.83279650445898e-06 5698/5721/5689/5696/6418/5715/5686/5711/5718/7514/5695/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-5687128 MAPK6/MAPK4 signaling 16/449 89/10554 8.87546693499108e-07 1.01941077367612e-05 6.74001624386541e-06 5698/5721/5689/5696/5715/5686/5711/5718/7514/5695/5062/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-5610787 Hedgehog 'off' state 18/449 111/10554 9.08509751450709e-07 1.02879132417799e-05 6.80203742746639e-06 5698/5721/5689/9978/5696/5715/5686/5711/8481/5718/51098/5695/5573/5684/5688/5690/5705/10213 18 ATL_GBP2 R-HSA-611105 Respiratory electron transport 17/449 100/10554 9.22313105849393e-07 1.02991630153182e-05 6.80947541599333e-06 9997/4716/4708/4701/4709/4694/55967/126328/4712/4717/51103/4714/4697/7386/4713/4731/4711 17 ATL_GBP2 R-HSA-69052 Switching of origins to a post-replicative state 16/449 90/10554 1.03793401767575e-06 1.1431492468648e-05 7.55813524046509e-06 5698/5721/5689/9978/5696/5715/5686/5711/5718/4175/5695/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-5689603 UCH proteinases 17/449 102/10554 1.23020242760893e-06 1.33659831323998e-05 8.83715826376261e-06 5698/5721/5689/5696/51377/4738/7347/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 17 ATL_GBP2 R-HSA-2871837 FCERI mediated NF-kB activation 15/449 82/10554 1.55004010927154e-06 1.63977927349252e-05 1.0841693285071e-05 5698/5721/5689/5696/5715/5686/5711/5718/5695/10892/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-9013694 Signaling by NOTCH4 15/449 82/10554 1.55004010927154e-06 1.63977927349252e-05 1.0841693285071e-05 5698/5721/5689/9978/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 14/449 72/10554 1.61245184612483e-06 1.6410269421321e-05 1.08499424689279e-05 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 14/449 72/10554 1.61245184612483e-06 1.6410269421321e-05 1.08499424689279e-05 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 14/449 72/10554 1.61245184612483e-06 1.6410269421321e-05 1.08499424689279e-05 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 15/449 83/10554 1.81938589621857e-06 1.82848282569967e-05 1.20893404946103e-05 5698/5721/5689/5696/5715/5686/5711/5718/5695/10892/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 14/449 73/10554 1.91874179432835e-06 1.90452889214814e-05 1.2592132633344e-05 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-69002 DNA Replication Pre-Initiation 15/449 85/10554 2.48718449092698e-06 2.43865406183572e-05 1.6123596507293e-05 5698/5721/5689/5696/5715/5686/5711/5718/4175/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-69620 Cell Cycle Checkpoints 31/449 293/10554 2.54630277414282e-06 2.46653907278413e-05 1.63079632332546e-05 5698/57060/5721/5689/5696/81565/10111/3017/5715/5932/8345/85236/5686/8347/5519/5711/8970/5718/5525/7514/4175/8339/5695/8379/4928/5684/5688/5690/7158/5705/10213 31 ATL_GBP2 R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 14/449 75/10554 2.69125050116966e-06 2.54560635640048e-05 1.68307306884295e-05 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 14/449 75/10554 2.69125050116966e-06 2.54560635640048e-05 1.68307306884295e-05 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-351202 Metabolism of polyamines 15/449 86/10554 2.89712697083544e-06 2.70847684250197e-05 1.79075779715043e-05 5698/5721/5689/5696/5715/5686/5711/5718/4946/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 14/449 76/10554 3.17280094526652e-06 2.89878631817532e-05 1.91658430306172e-05 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-5619084 ABC transporter disorders 14/449 76/10554 3.17280094526652e-06 2.89878631817532e-05 1.91658430306172e-05 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-8878166 Transcriptional regulation by RUNX2 18/449 121/10554 3.28787869306111e-06 2.97017356092262e-05 1.96378325250841e-05 5698/8493/5721/5689/9978/5696/5715/5686/5711/5718/11059/5695/5925/5684/5688/5690/5705/10213 18 ATL_GBP2 R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 19/449 134/10554 3.6593136682909e-06 3.26898687700654e-05 2.16134900875662e-05 5698/5721/5689/5696/5291/5715/5686/4214/5711/5718/27040/5695/10892/5062/5684/5688/5690/5705/10213 19 ATL_GBP2 R-HSA-453279 Mitotic G1-G1/S phases 20/449 149/10554 4.81132839974125e-06 4.25088794878238e-05 2.8105504243717e-05 5698/5721/5689/5696/5928/5715/3717/5686/5519/5711/5718/4175/5695/5925/5684/5688/5690/5520/5705/10213 20 ATL_GBP2 R-HSA-5607764 CLEC7A (Dectin-1) signaling 16/449 101/10554 5.02431508430266e-06 4.39081448671668e-05 2.90306535191401e-05 5698/5721/5689/5696/5715/5686/5711/5718/29108/5695/10892/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-8852135 Protein ubiquitination 14/449 79/10554 5.11019932910601e-06 4.41784974258197e-05 2.9209401937731e-05 92912/51322/7320/7347/3017/7323/7332/8345/85236/8347/8970/5194/8339/56852 14 ATL_GBP2 R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 12/449 59/10554 5.49631678572979e-06 4.70110499545399e-05 3.10821945889534e-05 51322/7320/3017/7323/7332/8345/85236/8347/8970/5194/8339/56852 12 ATL_GBP2 R-HSA-162599 Late Phase of HIV Life Cycle 19/449 138/10554 5.69394572438645e-06 4.79903957612322e-05 3.17297065454599e-05 6884/6883/5437/23165/5439/5435/9525/5436/2958/9972/9688/5441/6827/7514/137492/6880/4928/6879/7175 19 ATL_GBP2 R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 16/449 102/10554 5.73019650880385e-06 4.79903957612322e-05 3.17297065454599e-05 5698/5721/5689/5696/7293/5715/5686/5711/5718/7186/5695/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-162587 HIV Life Cycle 20/449 151/10554 5.91409837997941e-06 4.88755271590113e-05 3.23149269642586e-05 6884/6883/5437/23165/5439/5435/9525/3981/5436/2958/9972/9688/5441/6827/7514/137492/6880/4928/6879/7175 20 ATL_GBP2 R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 14/449 80/10554 5.95746475321283e-06 4.88755271590113e-05 3.23149269642586e-05 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-72766 Translation 30/449 291/10554 6.26774858387714e-06 5.09017157720931e-05 3.36545777231042e-05 51642/6183/51065/60559/2935/6301/9789/54516/10952/6727/92259/85476/9045/23480/64963/64960/5859/116832/6748/3735/51121/51258/64976/65993/6185/6745/84340/65008/10573/23471 30 ATL_GBP2 R-HSA-201681 TCF dependent signaling in response to WNT 26/449 233/10554 6.35887960392947e-06 5.11253920155929e-05 3.38024652629935e-05 5698/5721/5689/9978/5696/9101/3017/5715/8345/85236/5686/8347/83999/5519/5711/8970/5718/5525/7514/8339/5695/5684/5688/5690/5705/10213 26 ATL_GBP2 R-HSA-4086400 PCP/CE pathway 15/449 92/10554 6.89197304066235e-06 5.48628348979458e-05 3.62735423192755e-05 5698/5721/5689/5696/5715/5686/5880/5711/5718/5695/5684/5688/5690/5705/10213 15 ATL_GBP2 R-HSA-168325 Viral Messenger RNA Synthesis 10/449 42/10554 7.58639640248519e-06 5.97986539960597e-05 3.95369471956143e-05 5437/23165/5439/5435/5436/9972/9688/5441/4928/7175 10 ATL_GBP2 R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 31/449 309/10554 7.67031830221813e-06 5.98731642231396e-05 3.9586210961882e-05 9690/5698/5721/200845/23608/5689/7174/92912/9354/9978/5696/9616/9604/6478/7320/4734/5715/7323/7332/5686/5711/5718/4591/9320/11059/5695/5684/5688/5690/5705/10213 31 ATL_GBP2 R-HSA-5578749 Transcriptional regulation by small RNAs 16/449 105/10554 8.41051428574726e-06 6.50197450552e-05 4.29889647196596e-05 5437/23165/5439/5435/3017/5436/8345/85236/8347/9972/8970/9688/5441/8339/4928/7175 16 ATL_GBP2 R-HSA-69206 G1/S Transition 18/449 131/10554 1.03094063870628e-05 7.89405974780807e-05 5.21929847164582e-05 5698/5721/5689/5696/5928/5715/5686/5519/5711/5718/4175/5695/5925/5684/5688/5690/5705/10213 18 ATL_GBP2 R-HSA-195721 Signaling by WNT 32/449 330/10554 1.10653004727245e-05 8.39292601893441e-05 5.54913280906242e-05 5698/5721/50999/2787/5689/9978/5696/9101/9559/3017/5715/8345/85236/5686/5880/8347/83999/5519/51699/5711/8970/5718/5525/7514/8339/5695/80326/5684/5688/5690/5705/10213 32 ATL_GBP2 R-HSA-9010553 Regulation of expression of SLITs and ROBOs 21/449 171/10554 1.15166216381191e-05 8.65361102527828e-05 5.72148935292686e-05 5698/5721/51065/5689/2935/9978/5696/9045/5715/5686/26019/5711/5718/116832/51121/5695/5684/5688/5690/5705/10213 21 ATL_GBP2 R-HSA-68882 Mitotic Anaphase 23/449 199/10554 1.22524124478315e-05 9.12124037783008e-05 6.03067084420554e-05 5698/5721/5689/5696/81565/5715/7444/5686/5519/5711/5718/5525/7514/4001/5695/8379/4928/5684/5688/5690/5520/5705/10213 23 ATL_GBP2 R-HSA-2555396 Mitotic Metaphase and Anaphase 23/449 200/10554 1.33084134881016e-05 9.81648114168231e-05 6.49034168178786e-05 5698/5721/5689/5696/81565/5715/7444/5686/5519/5711/5718/5525/7514/4001/5695/8379/4928/5684/5688/5690/5520/5705/10213 23 ATL_GBP2 R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 14/449 86/10554 1.41918014450539e-05 0.000102794669926336 6.79645303912017e-05 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-453276 Regulation of mitotic cell cycle 14/449 86/10554 1.41918014450539e-05 0.000102794669926336 6.79645303912017e-05 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-5358351 Signaling by Hedgehog 19/449 147/10554 1.44232176497086e-05 0.000103538098128265 6.84560612133727e-05 5698/5721/5689/9978/5696/25989/5715/5686/5711/8481/5718/51098/5695/5573/5684/5688/5690/5705/10213 19 ATL_GBP2 R-HSA-211000 Gene Silencing by RNA 18/449 135/10554 1.57259890417719e-05 0.00011189110787243 7.39788026650658e-05 143689/5437/23165/5439/5435/57510/3017/5436/8345/85236/8347/9972/8970/9688/5441/8339/4928/7175 18 ATL_GBP2 R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 17/449 123/10554 1.6753264917817e-05 0.000118154605209867 7.81200257017321e-05 9997/4716/4708/4701/4709/4694/55967/126328/4712/4717/51103/4714/4697/7386/4713/4731/4711 17 ATL_GBP2 R-HSA-983705 Signaling by the B Cell Receptor (BCR) 16/449 112/10554 1.94382940910434e-05 0.000135899029993034 8.98520687961272e-05 5698/4690/5721/5689/5696/5715/5686/5711/5718/5695/10892/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-167161 HIV Transcription Initiation 10/449 47/10554 2.20532965404591e-05 0.000146535953872141 9.68848608345528e-05 6884/6883/5437/5439/5435/5436/2958/5441/6880/6879 10 ATL_GBP2 R-HSA-167162 RNA Polymerase II HIV Promoter Escape 10/449 47/10554 2.20532965404591e-05 0.000146535953872141 9.68848608345528e-05 6884/6883/5437/5439/5435/5436/2958/5441/6880/6879 10 ATL_GBP2 R-HSA-73776 RNA Polymerase II Promoter Escape 10/449 47/10554 2.20532965404591e-05 0.000146535953872141 9.68848608345528e-05 6884/6883/5437/5439/5435/5436/2958/5441/6880/6879 10 ATL_GBP2 R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 10/449 47/10554 2.20532965404591e-05 0.000146535953872141 9.68848608345528e-05 6884/6883/5437/5439/5435/5436/2958/5441/6880/6879 10 ATL_GBP2 R-HSA-75953 RNA Polymerase II Transcription Initiation 10/449 47/10554 2.20532965404591e-05 0.000146535953872141 9.68848608345528e-05 6884/6883/5437/5439/5435/5436/2958/5441/6880/6879 10 ATL_GBP2 R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 10/449 47/10554 2.20532965404591e-05 0.000146535953872141 9.68848608345528e-05 6884/6883/5437/5439/5435/5436/2958/5441/6880/6879 10 ATL_GBP2 R-HSA-6807070 PTEN Regulation 18/449 140/10554 2.59949867893258e-05 0.000171311224414901 0.000113265473068245 5698/5721/23608/5689/5696/5928/6009/4734/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 18 ATL_GBP2 R-HSA-9020591 Interleukin-12 signaling 10/449 48/10554 2.68132905223553e-05 0.00017526736243881 0.000115881144319978 5721/4478/9446/3936/3717/6950/4001/3716/5062/6888 10 ATL_GBP2 R-HSA-2262752 Cellular responses to stress 37/449 426/10554 2.7573102004109e-05 0.000178780435575029 0.000118203875314729 5698/5721/5689/9978/5696/23165/5928/2876/23043/10111/3017/50488/5715/7323/25994/8345/85236/5686/7295/8347/9972/5711/8970/9688/5718/5052/8339/4001/5695/5925/4928/5684/5688/5690/7175/5705/10213 37 ATL_GBP2 R-HSA-68875 Mitotic Prophase 18/449 141/10554 2.86521917915285e-05 0.000184290897603111 0.000121847215618711 23165/5861/6418/3017/7444/8345/85236/8347/5519/84930/9972/8970/9688/8339/4001/5925/4928/7175 18 ATL_GBP2 R-HSA-5621481 C-type lectin receptors (CLRs) 18/449 142/10554 3.15486294538258e-05 0.000201310302229174 0.000133099898698263 5698/5721/5689/5696/5715/3385/5686/5711/5718/29108/5695/10892/5062/5684/5688/5690/5705/10213 18 ATL_GBP2 R-HSA-69239 Synthesis of DNA 16/449 119/10554 4.17992541096763e-05 0.000264618900032911 0.000174957507877219 5698/5721/5689/9978/5696/5715/5686/5711/5718/4175/5695/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 20/449 174/10554 4.88268170494438e-05 0.000306693444591819 0.000202775843831983 9997/4716/4708/4701/3418/4709/4694/55967/126328/4712/4717/51103/4714/4697/7386/4713/4731/7416/3029/4711 20 ATL_GBP2 R-HSA-8878159 Transcriptional regulation by RUNX3 14/449 96/10554 5.07204489538134e-05 0.000316118146967953 0.000209007153991642 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-376176 Signaling by ROBO receptors 23/449 218/10554 5.3118838689937e-05 0.000328519586974687 0.000217206587355613 5698/4690/5721/51065/5689/2935/9978/5696/9045/5715/5686/26019/5711/5718/116832/51121/5695/5062/5684/5688/5690/5705/10213 23 ATL_GBP2 R-HSA-5663202 Diseases of signal transduction 33/449 378/10554 6.82364840602374e-05 0.000418794909804816 0.000276893728006588 5698/5721/5689/5437/9978/5696/8826/5439/5291/5435/7750/3932/56829/5436/5715/3717/5686/5880/83999/5519/5711/5718/5906/5441/5525/57534/8805/5695/5684/5688/5690/5705/10213 33 ATL_GBP2 R-HSA-8878171 Transcriptional regulation by RUNX1 24/449 239/10554 8.10213965002235e-05 0.000493493960501361 0.000326282338378093 5698/5721/200845/5689/5696/122809/3017/5715/8345/85236/5686/8347/5711/8970/5718/8339/5695/5684/5688/5690/5705/10213/6605/6688 24 ATL_GBP2 R-HSA-69306 DNA Replication 16/449 127/10554 9.28407736689715e-05 0.00056123294759288 0.0003710691784949 5698/5721/5689/9978/5696/5715/5686/5711/5718/4175/5695/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-109581 Apoptosis 19/449 169/10554 0.000101363013114969 0.000608178078689815 0.000402107789654827 5698/5721/8743/5689/6093/5696/5715/5686/5711/5718/7186/4001/5695/5062/5684/5688/5690/5705/10213 19 ATL_GBP2 R-HSA-382556 ABC-family proteins mediated transport 14/449 103/10554 0.000111139252910916 0.000661895995113899 0.000437624348694055 5698/5721/5689/5696/5715/5686/5711/5718/5695/5684/5688/5690/5705/10213 14 ATL_GBP2 R-HSA-5619115 Disorders of transmembrane transporters 17/449 144/10554 0.000128011188114754 0.000752910289682455 0.000497800073696831 5698/5721/5689/5696/9197/285195/5715/5686/5711/5718/5695/5684/5688/5690/7175/5705/10213 17 ATL_GBP2 R-HSA-5357801 Programmed Cell Death 19/449 172/10554 0.000128294415032956 0.000752910289682455 0.000497800073696831 5698/5721/8743/5689/6093/5696/5715/5686/5711/5718/7186/4001/5695/5062/5684/5688/5690/5705/10213 19 ATL_GBP2 R-HSA-2467813 Separation of Sister Chromatids 20/449 188/10554 0.00014449872340291 0.000839173112565019 0.000554834278404471 5698/5721/5689/5696/81565/5715/5686/5519/5711/5718/5525/7514/5695/8379/4928/5684/5688/5690/5705/10213 20 ATL_GBP2 R-HSA-5368287 Mitochondrial translation 13/449 93/10554 0.000145679661776661 0.000839173112565019 0.000554834278404471 51642/6183/54516/92259/85476/64963/64960/51258/64976/65993/84340/65008/10573 13 ATL_GBP2 R-HSA-447115 Interleukin-12 family signaling 10/449 58/10554 0.000146124671342167 0.000839173112565019 0.000554834278404471 5721/4478/9446/3936/3717/6950/4001/3716/5062/6888 10 ATL_GBP2 R-HSA-449147 Signaling by Interleukins 37/449 462/10554 0.000151549363816735 0.000864153819210317 0.00057135071838336 4615/5698/11213/29110/5721/5689/3560/4478/9446/10392/9978/1326/5696/5291/3932/3936/5715/3717/5686/5519/5771/5711/5718/6950/4001/6095/9655/5695/3716/4170/5062/5684/5688/5690/6888/5705/10213 37 ATL_GBP2 R-HSA-69242 S Phase 18/449 161/10554 0.000164843966253511 0.00093334189343537 0.000617095648317442 5698/5721/5689/9978/5696/5928/5715/5686/5711/5718/4175/5695/5925/5684/5688/5690/5705/10213 18 ATL_GBP2 R-HSA-157118 Signaling by NOTCH 23/449 235/10554 0.000167188059608758 0.000939994405073015 0.000621494075100645 5698/5721/5689/9978/5696/3017/5715/8345/85236/5686/10959/8347/5711/8970/5718/57534/8339/5695/5684/5688/5690/5705/10213 23 ATL_GBP2 R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 8/449 39/10554 0.000193631237538741 0.00108110774292464 0.000714793676586726 5721/4478/9446/3936/6950/4001/5062/6888 8 ATL_GBP2 R-HSA-167172 Transcription of the HIV genome 11/449 73/10554 0.000239254931683771 0.00132662734533622 0.000877123343014915 6884/6883/5437/5439/5435/5436/2958/5441/6827/6880/6879 11 ATL_GBP2 R-HSA-1257604 PIP3 activates AKT signaling 24/449 260/10554 0.000295005220642843 0.0016182736072751 0.00106995047351915 4615/5698/5721/23608/5689/5696/5928/5291/3932/6009/4734/5715/5686/5880/5519/5711/5718/5525/5695/5684/5688/5690/5705/10213 24 ATL_GBP2 R-HSA-5419276 Mitochondrial translation termination 12/449 87/10554 0.000295878383419701 0.0016182736072751 0.00106995047351915 51642/6183/54516/92259/64963/64960/51258/64976/65993/84340/65008/10573 12 ATL_GBP2 R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 6/449 23/10554 0.000311914401101362 0.00169445390868578 0.0011203184392332 5437/5439/5435/5436/5441/6827 6 ATL_GBP2 R-HSA-5673001 RAF/MAP kinase cascade 23/449 248/10554 0.000367052349748546 0.0019806046254888 0.00130951209200294 5698/5721/5689/3560/9978/5696/8826/5715/3717/5686/5519/5711/5718/5906/5525/27040/5695/3716/5684/5688/5690/5705/10213 23 ATL_GBP2 R-HSA-203927 MicroRNA (miRNA) biogenesis 6/449 24/10554 0.000401103495730178 0.00214991473711376 0.00142145449364028 5437/5439/5435/57510/5436/5441 6 ATL_GBP2 R-HSA-3858494 Beta-catenin independent WNT signaling 16/449 145/10554 0.000435778862219677 0.00232030599486504 0.00153411171433208 5698/5721/2787/5689/5696/5715/5686/5880/5711/5718/5695/5684/5688/5690/5705/10213 16 ATL_GBP2 R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 7/449 34/10554 0.000476624660378035 0.0025210935983154 0.00166686602140518 29110/54941/8887/84282/7323/9636/9641 7 ATL_GBP2 R-HSA-5684996 MAPK1/MAPK3 signaling 23/449 254/10554 0.000515289747831357 0.00270779710625105 0.00179030837739825 5698/5721/5689/3560/9978/5696/8826/5715/3717/5686/5519/5711/5718/5906/5525/27040/5695/3716/5684/5688/5690/5705/10213 23 ATL_GBP2 R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 10/449 69/10554 0.000627162556811135 0.00327427724465034 0.00216484682973085 22976/10111/3017/3981/8345/85236/8347/8970/8339/7158 10 ATL_GBP2 R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 14/449 122/10554 0.000661733243344374 0.00341047133108254 0.00225489398035701 5437/5439/5928/5435/22976/63925/3017/5436/8345/85236/8347/8970/5441/8339 14 ATL_GBP2 R-HSA-5619507 Activation of HOX genes during differentiation 14/449 122/10554 0.000661733243344374 0.00341047133108254 0.00225489398035701 5437/5439/5928/5435/22976/63925/3017/5436/8345/85236/8347/8970/5441/8339 14 ATL_GBP2 R-HSA-5683057 MAPK family signaling cascades 25/449 293/10554 0.000722465382474077 0.00367634283233644 0.00243067966788414 5698/5721/5689/3560/9978/5696/8826/5715/3717/5686/5519/5711/5718/5906/5525/7514/27040/5695/3716/5062/5684/5688/5690/5705/10213 25 ATL_GBP2 R-HSA-9006925 Intracellular signaling by second messengers 25/449 293/10554 0.000722465382474077 0.00367634283233644 0.00243067966788414 4615/5698/5721/23608/5689/5696/5928/5291/3932/6009/4734/5715/5686/5880/5519/5711/5718/5525/5695/5573/5684/5688/5690/5705/10213 25 ATL_GBP2 R-HSA-674695 RNA Polymerase II Pre-transcription Events 11/449 84/10554 0.000820678674984835 0.00414984688482898 0.00274374532186257 6884/6883/5437/5439/5435/5436/2958/5441/6827/6880/6879 11 ATL_GBP2 R-HSA-168254 Influenza Infection 16/449 154/10554 0.000847784650410569 0.00426011786831311 0.00281665295037722 51065/5437/23165/5439/5435/9045/5436/9636/9972/9688/116832/5441/51121/7514/4928/7175 16 ATL_GBP2 R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 13/449 112/10554 0.000916630709237142 0.00457746018774324 0.00302646948783757 51065/60559/9789/10952/6727/9045/23480/116832/6748/51121/6185/6745/23471 13 ATL_GBP2 R-HSA-73894 DNA Repair 26/449 316/10554 0.000976353169580909 0.00484560461940155 0.00320375796386198 5437/9978/4350/5439/5435/22976/10111/7320/3017/3981/5436/5932/8345/85236/8347/9636/5980/8970/5441/4292/8339/56852/8467/7158/23583/6613 26 ATL_GBP2 R-HSA-8951664 Neddylation 21/449 234/10554 0.00100004499390018 0.00493273727052606 0.00326136727103386 5698/5721/200845/5689/9978/5696/9616/4738/7347/5715/7323/5686/5711/5718/9655/5695/5684/5688/5690/5705/10213 21 ATL_GBP2 R-HSA-6807505 RNA polymerase II transcribes snRNA genes 10/449 74/10554 0.00109659449780941 0.00535524220545165 0.00354071394835439 6619/6884/5437/5439/5435/5436/2958/5441/6827/6880 10 ATL_GBP2 R-HSA-5389840 Mitochondrial translation elongation 11/449 87/10554 0.00110380872482436 0.00535524220545165 0.00354071394835439 51642/6183/92259/85476/64963/64960/51258/64976/65993/65008/10573 11 ATL_GBP2 R-HSA-168255 Influenza Life Cycle 15/449 143/10554 0.00110568433595146 0.00535524220545165 0.00354071394835439 51065/5437/23165/5439/5435/9045/5436/9972/9688/116832/5441/51121/7514/4928/7175 15 ATL_GBP2 R-HSA-15869 Metabolism of nucleotides 12/449 101/10554 0.00116263394082611 0.00559735142768977 0.00370078878107271 11164/4831/2987/3251/2876/30833/4830/50484/7295/4521/4832/7084 12 ATL_GBP2 R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 6/449 29/10554 0.00118179883181343 0.00565575155224998 0.00373940106557507 143689/5437/5439/5435/5436/5441 6 ATL_GBP2 R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 6/449 30/10554 0.00142500031290051 0.00673941324454126 0.00445588333136074 23165/9972/9688/7514/4928/7175 6 ATL_GBP2 R-HSA-499943 Interconversion of nucleotide di- and triphosphates 6/449 30/10554 0.00142500031290051 0.00673941324454126 0.00445588333136074 4831/2987/4830/50484/7295/4832 6 ATL_GBP2 R-HSA-72165 mRNA Splicing - Minor Pathway 8/449 52/10554 0.00145986925647548 0.00683859944488724 0.00452146205769581 5437/5439/5435/10907/5436/55954/5441/6634 8 ATL_GBP2 R-HSA-70326 Glucose metabolism 11/449 90/10554 0.00146298396084652 0.00683859944488724 0.00452146205769581 23165/5313/5519/9972/5106/9688/8604/7167/4928/7175/5214 11 ATL_GBP2 R-HSA-168273 Influenza Viral RNA Transcription and Replication 14/449 133/10554 0.00154892383217224 0.00719846682697386 0.00475939479919062 51065/5437/23165/5439/5435/9045/5436/9972/9688/116832/5441/51121/4928/7175 14 ATL_GBP2 R-HSA-6807004 Negative regulation of MET activity 5/449 21/10554 0.00157464498903888 0.00727594581142102 0.00481062141236923 5795/9101/5771/8027/10254 5 ATL_GBP2 R-HSA-5250924 B-WICH complex positively regulates rRNA expression 11/449 91/10554 0.00160207851890847 0.00736040645258521 0.00486646407247386 5437/5435/3017/8345/85236/8347/9014/8970/5441/8339/8467 11 ATL_GBP2 R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 10/449 78/10554 0.00165134552636539 0.00754364660907825 0.00498761657185718 29110/54941/8887/84282/7323/9636/4214/7186/9641/10010 10 ATL_GBP2 R-HSA-5250913 Positive epigenetic regulation of rRNA expression 12/449 106/10554 0.0017730331645983 0.00805377776461601 0.0053248988886241 5437/5928/5435/3017/8345/85236/8347/9014/8970/5441/8339/8467 12 ATL_GBP2 R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 6/449 32/10554 0.00202384298248543 0.00914140313437239 0.00604400181049759 23165/9972/9688/7514/4928/7175 6 ATL_GBP2 R-HSA-9007101 Rab regulation of trafficking 13/449 124/10554 0.00233477267118485 0.010484176246419 0.00693180021529404 10133/26088/51552/5861/51399/6399/117177/201475/374403/9363/4218/23682/27342 13 ATL_GBP2 R-HSA-113418 Formation of the Early Elongation Complex 6/449 33/10554 0.00238632369787895 0.010484176246419 0.00693180021529404 5437/5439/5435/5436/5441/6827 6 ATL_GBP2 R-HSA-165054 Rev-mediated nuclear export of HIV RNA 6/449 33/10554 0.00238632369787895 0.010484176246419 0.00693180021529404 23165/9972/9688/7514/4928/7175 6 ATL_GBP2 R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 6/449 33/10554 0.00238632369787895 0.010484176246419 0.00693180021529404 5437/5439/5435/5436/5441/6827 6 ATL_GBP2 R-HSA-4085377 SUMOylation of SUMOylation proteins 6/449 33/10554 0.00238632369787895 0.010484176246419 0.00693180021529404 23165/9972/9688/4928/7175/6613 6 ATL_GBP2 R-HSA-73980 RNA Polymerase III Transcription Termination 5/449 23/10554 0.00242734312978624 0.0106064341105877 0.00701263318387902 5437/5435/51728/5441/6741 5 ATL_GBP2 R-HSA-70171 Glycolysis 9/449 70/10554 0.00273039688713611 0.0118661572824726 0.00784552163871256 23165/5313/5519/9972/9688/7167/4928/7175/5214 9 ATL_GBP2 R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 6/449 34/10554 0.00279554492020057 0.0120193482130549 0.00794680655615699 5437/5439/5435/5436/5441/6827 6 ATL_GBP2 R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 6/449 34/10554 0.00279554492020057 0.0120193482130549 0.00794680655615699 5437/5439/5435/5436/5441/6827 6 ATL_GBP2 R-HSA-177243 Interactions of Rev with host cellular proteins 6/449 35/10554 0.00325511800512712 0.0139208238091607 0.00920400107832697 23165/9972/9688/7514/4928/7175 6 ATL_GBP2 R-HSA-5368286 Mitochondrial translation initiation 10/449 87/10554 0.0037405589343744 0.0158640828760217 0.0104888214878122 51642/6183/92259/64963/64960/51258/64976/65993/65008/10573 10 ATL_GBP2 R-HSA-167287 HIV elongation arrest and recovery 6/449 36/10554 0.00376870625537332 0.0158640828760217 0.0104888214878122 5437/5439/5435/5436/5441/6827 6 ATL_GBP2 R-HSA-167290 Pausing and recovery of HIV elongation 6/449 36/10554 0.00376870625537332 0.0158640828760217 0.0104888214878122 5437/5439/5435/5436/5441/6827 6 ATL_GBP2 R-HSA-6803529 FGFR2 alternative splicing 5/449 26/10554 0.00427230651781887 0.0178902835433665 0.0118284802165489 5437/5439/5435/5436/5441 5 ATL_GBP2 R-HSA-73777 RNA Polymerase I Chain Elongation 10/449 90/10554 0.00477844057943474 0.0198187568893481 0.0131035247828238 5437/5435/3017/8345/85236/8347/9014/8970/5441/8339 10 ATL_GBP2 R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 9/449 76/10554 0.00478213785638498 0.0198187568893481 0.0131035247828238 10111/3017/8345/85236/8347/8970/8339/8467/7158 9 ATL_GBP2 R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 5/449 27/10554 0.00506339701347018 0.0207702612185205 0.0137326288496372 5437/5439/5435/5436/5441 5 ATL_GBP2 R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 5/449 27/10554 0.00506339701347018 0.0207702612185205 0.0137326288496372 5437/5439/5435/5436/5441 5 ATL_GBP2 R-HSA-5693606 DNA Double Strand Break Response 9/449 77/10554 0.0052171967184016 0.0212925185867761 0.0140779286283345 10111/3017/8345/85236/8347/8970/8339/8467/7158 9 ATL_GBP2 R-HSA-427413 NoRC negatively regulates rRNA expression 11/449 106/10554 0.00533043266560719 0.0216447871876171 0.0143108373000087 5437/5435/3017/8345/85236/8347/9014/8970/5441/8339/8467 11 ATL_GBP2 R-HSA-2980766 Nuclear Envelope Breakdown 7/449 51/10554 0.00550951272920271 0.0221539108208821 0.0146474534754457 23165/7444/9972/9688/4001/4928/7175 7 ATL_GBP2 R-HSA-8873719 RAB geranylgeranylation 8/449 64/10554 0.00551092308977167 0.0221539108208821 0.0146474534754457 51552/5861/84932/53917/201475/9363/4218/23682 8 ATL_GBP2 R-HSA-168276 NS1 Mediated Effects on Host Pathways 6/449 39/10554 0.00567068018836281 0.0226827207534512 0.0149970855989695 23165/9636/9972/9688/4928/7175 6 ATL_GBP2 R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 5/449 28/10554 0.0059528996490392 0.0236937193951857 0.0156655253922084 6619/5437/5435/51728/5441 5 ATL_GBP2 R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 12/449 123/10554 0.00606452064677296 0.0240190866995343 0.0158806477916533 27010/55191/79668/9446/55312/55788/5095/51248/23475/4594/4522/65220 12 ATL_GBP2 R-HSA-5250941 Negative epigenetic regulation of rRNA expression 11/449 109/10554 0.00656946709221727 0.0257651294738668 0.0170350751300114 5437/5435/3017/8345/85236/8347/9014/8970/5441/8339/8467 11 ATL_GBP2 R-HSA-73854 RNA Polymerase I Promoter Clearance 11/449 109/10554 0.00656946709221727 0.0257651294738668 0.0170350751300114 5437/5928/5435/3017/8345/85236/8347/9014/8970/5441/8339 11 ATL_GBP2 R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 9/449 80/10554 0.00670804402537726 0.0261809096912782 0.017309975640345 10111/3017/8345/85236/8347/8970/8339/4001/5925 9 ATL_GBP2 R-HSA-72086 mRNA Capping 5/449 29/10554 0.00694687898596124 0.0268523591572733 0.0177539164367937 5437/5439/5435/5436/5441 5 ATL_GBP2 R-HSA-933541 TRAF6 mediated IRF7 activation 5/449 29/10554 0.00694687898596124 0.0268523591572733 0.0177539164367937 29110/84282/7186/9641/10010 5 ATL_GBP2 R-HSA-168253 Host Interactions with Influenza Factors 6/449 41/10554 0.00727696379860019 0.0277283359908747 0.0183330841521232 23165/9636/9972/9688/4928/7175 6 ATL_GBP2 R-HSA-74158 RNA Polymerase III Transcription 6/449 41/10554 0.00727696379860019 0.0277283359908747 0.0183330841521232 6619/5437/5435/51728/5441/6741 6 ATL_GBP2 R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 6/449 41/10554 0.00727696379860019 0.0277283359908747 0.0183330841521232 6619/5437/5435/51728/5441/6741 6 ATL_GBP2 R-HSA-9609507 Protein localization 12/449 127/10554 0.00778899253322919 0.0295393867769635 0.0195304926975211 3416/54469/373156/6342/7323/10531/6901/5194/8604/4714/4358/7416 12 ATL_GBP2 R-HSA-204005 COPII-mediated vesicle transport 8/449 68/10554 0.00794479334012117 0.0299685592376898 0.0198142477285066 5861/10484/10427/51399/6399/23256/9117/10959 8 ATL_GBP2 R-HSA-73864 RNA Polymerase I Transcription 11/449 112/10554 0.00802363983419425 0.0299685592376898 0.0198142477285066 5437/5928/5435/3017/8345/85236/8347/9014/8970/5441/8339 11 ATL_GBP2 R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 5/449 30/10554 0.00805125472057337 0.0299685592376898 0.0198142477285066 23165/9972/9688/4928/7175 5 ATL_GBP2 R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 5/449 30/10554 0.00805125472057337 0.0299685592376898 0.0198142477285066 23165/9972/9688/4928/7175 5 ATL_GBP2 R-HSA-5693607 Processing of DNA double-strand break ends 10/449 98/10554 0.00866832132230274 0.0321167296918498 0.0212345489583453 10111/3017/5932/8345/85236/8347/8970/8339/7158/6613 10 ATL_GBP2 R-HSA-5627117 RHO GTPases Activate ROCKs 4/449 20/10554 0.00910157481904865 0.0334140007055485 0.0220922628388348 6093/4659/5500/4637 4 ATL_GBP2 R-HSA-622312 Inflammasomes 4/449 20/10554 0.00910157481904865 0.0334140007055485 0.0220922628388348 24145/7295/22861/29108 4 ATL_GBP2 R-HSA-6784531 tRNA processing in the nucleus 7/449 56/10554 0.00920626199616465 0.0336447029314381 0.0222447957323596 23165/339487/10775/9972/9688/4928/7175 7 ATL_GBP2 R-HSA-1169408 ISG15 antiviral mechanism 8/449 71/10554 0.0102430300531648 0.0371855410233023 0.0245858840230003 23165/4734/9636/9972/9688/3716/4928/7175 8 ATL_GBP2 R-HSA-4615885 SUMOylation of DNA replication proteins 6/449 44/10554 0.0102676493870312 0.0371855410233023 0.0245858840230003 23165/9972/9688/4928/7175/6613 6 ATL_GBP2 R-HSA-180746 Nuclear import of Rev protein 5/449 32/10554 0.0106139828189056 0.0378801672406061 0.0250451485421656 23165/9972/9688/4928/7175 5 ATL_GBP2 R-HSA-180910 Vpr-mediated nuclear import of PICs 5/449 32/10554 0.0106139828189056 0.0378801672406061 0.0250451485421656 23165/9972/9688/4928/7175 5 ATL_GBP2 R-HSA-2173789 TGF-beta receptor signaling activates SMADs 5/449 32/10554 0.0106139828189056 0.0378801672406061 0.0250451485421656 5499/5500/51377/4738/7514 5 ATL_GBP2 R-HSA-912446 Meiotic recombination 9/449 86/10554 0.0106479077069365 0.0378801672406061 0.0250451485421656 10111/3017/5932/8345/85236/8347/8970/4292/8339 9 ATL_GBP2 R-HSA-9018519 Estrogen-dependent gene expression 13/449 150/10554 0.0115426441456829 0.0408823167098195 0.02703007323705 200845/5437/5439/5435/3017/5436/8345/85236/2958/8347/8970/5441/8339 13 ATL_GBP2 R-HSA-1500620 Meiosis 11/449 118/10554 0.011672043098403 0.0411593098733158 0.0272132122100347 10111/3017/5932/8345/85236/8347/8970/4292/10388/8339/4001 11 ATL_GBP2 R-HSA-159227 Transport of the SLBP independent Mature mRNA 5/449 33/10554 0.0120832076619461 0.0422386911313246 0.0279268643903102 23165/9972/9688/4928/7175 5 ATL_GBP2 R-HSA-1839126 FGFR2 mutant receptor activation 5/449 33/10554 0.0120832076619461 0.0422386911313246 0.0279268643903102 5437/5439/5435/5436/5441 5 ATL_GBP2 R-HSA-167169 HIV Transcription Elongation 6/449 46/10554 0.0126906603056136 0.0434182590881418 0.0287067567943331 5437/5439/5435/5436/5441/6827 6 ATL_GBP2 R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 6/449 46/10554 0.0126906603056136 0.0434182590881418 0.0287067567943331 5437/5439/5435/5436/5441/6827 6 ATL_GBP2 R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 6/449 46/10554 0.0126906603056136 0.0434182590881418 0.0287067567943331 5437/5439/5435/5436/5441/6827 6 ATL_GBP2 R-HSA-4570464 SUMOylation of RNA binding proteins 6/449 46/10554 0.0126906603056136 0.0434182590881418 0.0287067567943331 23165/9972/9688/4928/7175/6613 6 ATL_GBP2 R-HSA-8854214 TBC/RABGAPs 6/449 46/10554 0.0126906603056136 0.0434182590881418 0.0287067567943331 10133/26088/374403/9363/4218/27342 6 ATL_GBP2 R-HSA-2299718 Condensation of Prophase Chromosomes 8/449 74/10554 0.0130010150736985 0.0439193954590487 0.0290380920487295 6418/3017/8345/85236/8347/8970/8339/5925 8 ATL_GBP2 R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 8/449 74/10554 0.0130010150736985 0.0439193954590487 0.0290380920487295 5928/3017/8345/85236/8347/8970/8339/8467 8 ATL_GBP2 R-HSA-774815 Nucleosome assembly 8/449 74/10554 0.0130010150736985 0.0439193954590487 0.0290380920487295 5928/3017/8345/85236/8347/8970/8339/8467 8 ATL_GBP2 R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 5/449 34/10554 0.013684528824316 0.0458431715614586 0.0303100309485947 23165/9972/9688/4928/7175 5 ATL_GBP2 R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 5/449 34/10554 0.013684528824316 0.0458431715614586 0.0303100309485947 23165/9972/9688/4928/7175 5 ATL_GBP2 R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 9/449 90/10554 0.0141043251477139 0.0470534332728713 0.031110217076198 51552/5861/51399/6399/117177/201475/4218/23682/27342 9 ATL_GBP2 R-HSA-72306 tRNA processing 10/449 106/10554 0.0146248816751006 0.0483884973941598 0.0319929185441879 23165/339487/63892/10775/9972/9688/83480/54517/4928/7175 10 ATL_GBP2 R-HSA-977225 Amyloid fiber formation 10/449 106/10554 0.0146248816751006 0.0483884973941598 0.0319929185441879 26088/6478/3017/8345/85236/8347/8970/6653/8339/4240 10 ATL_GBP2 R-HSA-3108214 SUMOylation of DNA damage response and repair proteins 8/449 76/10554 0.0151189785734144 0.0498182736599392 0.0329382406366448 23165/9972/197370/9688/6672/4928/7175/6613 8