Cluster ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count HAM_CD40LG R-HSA-6798695 Neutrophil degranulation 34/132 479/10554 4.47449528785024e-17 2.12985975701671e-14 1.85573804569789e-14 5594/5023/11031/5724/338339/5329/121260/965/57153/6402/4033/10970/5611/116844/2212/8972/6515/54918/7077/3920/6283/25801/978/158747/6386/64386/25797/23593/4318/6282/3482/8993/4311/1604 34 HAM_CD40LG R-HSA-449147 Signaling by Interleukins 21/132 462/10554 2.5277983643453e-07 6.01616010714181e-05 5.24185555553709e-05 5594/6648/5724/6416/1052/3557/4170/2353/57162/3597/8660/3055/6283/7850/1441/5595/4318/57161/3588/6888/9846 21 HAM_CD40LG R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 8/132 93/10554 2.02048901542075e-05 0.00141043912921419 0.00122890981183191 5594/6416/7099/2353/57162/6283/5595/57161 8 HAM_CD40LG R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 8/132 94/10554 2.1854752414833e-05 0.00141043912921419 0.00122890981183191 5594/6416/7099/2353/57162/6283/5595/57161 8 HAM_CD40LG R-HSA-975155 MyD88 dependent cascade initiated on endosome 8/132 94/10554 2.1854752414833e-05 0.00141043912921419 0.00122890981183191 5594/6416/7099/2353/57162/6283/5595/57161 8 HAM_CD40LG R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 8/132 95/10554 2.36162299368958e-05 0.00141043912921419 0.00122890981183191 5594/6416/7099/2353/57162/6283/5595/57161 8 HAM_CD40LG R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 8/132 95/10554 2.36162299368958e-05 0.00141043912921419 0.00122890981183191 5594/6416/7099/2353/57162/6283/5595/57161 8 HAM_CD40LG R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 8/132 98/10554 2.96310741431552e-05 0.00141043912921419 0.00122890981183191 5594/6416/7099/2353/57162/6283/5595/57161 8 HAM_CD40LG R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 8/132 98/10554 2.96310741431552e-05 0.00141043912921419 0.00122890981183191 5594/6416/7099/2353/57162/6283/5595/57161 8 HAM_CD40LG R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 8/132 98/10554 2.96310741431552e-05 0.00141043912921419 0.00122890981183191 5594/6416/7099/2353/57162/6283/5595/57161 8 HAM_CD40LG R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 9/132 130/10554 3.4993941280877e-05 0.00151428327724522 0.00131938879087709 5594/6416/7099/5336/2353/57162/6283/5595/57161 9 HAM_CD40LG R-HSA-2871796 FCERI mediated MAPK activation 5/132 32/10554 4.35529847159183e-05 0.00172760172706476 0.00150525227877823 5594/6416/5336/2353/5595 5 HAM_CD40LG R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 7/132 85/10554 8.95769311908293e-05 0.00284257461645565 0.002476723571171 5594/6416/2353/57162/6283/5595/57161 7 HAM_CD40LG R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 7/132 85/10554 8.95769311908293e-05 0.00284257461645565 0.002476723571171 5594/6416/2353/57162/6283/5595/57161 7 HAM_CD40LG R-HSA-975871 MyD88 cascade initiated on plasma membrane 7/132 85/10554 8.95769311908293e-05 0.00284257461645565 0.002476723571171 5594/6416/2353/57162/6283/5595/57161 7 HAM_CD40LG R-HSA-168898 Toll-like Receptor Cascades 9/132 155/10554 0.000137300048373185 0.00408467643910226 0.00355896178019967 5594/6416/7099/5336/2353/57162/6283/5595/57161 9 HAM_CD40LG R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 8/132 134/10554 0.000269467737641739 0.00754509665396869 0.00657401167992849 5594/5530/6416/5336/2353/5595/7462/9846 8 HAM_CD40LG R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 6/132 86/10554 0.00070835743738344 0.0187321188996954 0.0163212181478992 5594/5336/7454/2212/3055/5595 6 HAM_CD40LG R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 6/132 99/10554 0.00147947799444792 0.0353154138973366 0.030770174868533 5594/6416/7099/2353/6283/5595 6 HAM_CD40LG R-HSA-166166 MyD88-independent TLR4 cascade 6/132 100/10554 0.00155803296605897 0.0353154138973366 0.030770174868533 5594/6416/7099/2353/6283/5595 6 HAM_CD40LG R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling 6/132 100/10554 0.00155803296605897 0.0353154138973366 0.030770174868533 5594/6416/7099/2353/6283/5595 6 HAM_CD40LG R-HSA-9020702 Interleukin-1 signaling 6/132 103/10554 0.00181284953311999 0.0392234717165961 0.0341752495717356 6416/3557/57162/6283/7850/57161 6 HAM_GBP2 R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins 10/127 181/10554 6.34541491092254e-05 0.0186463573894349 0.0176517971754452 51588/6996/23512/9112/8924/8364/79902/6015/6095/115426 10 HAM_GBP2 R-HSA-2990846 SUMOylation 10/127 187/10554 8.34288921227511e-05 0.0186463573894349 0.0176517971754452 51588/6996/23512/9112/8924/8364/79902/6015/6095/115426 10 HAM_GBP2 R-HSA-72312 rRNA processing 10/127 205/10554 0.000178182767102711 0.026549232298304 0.0251331482018561 84946/9692/51106/23160/10199/10557/387338/84128/55623/6222 10 HAM_GBP2 R-HSA-72306 tRNA processing 7/127 106/10554 0.00028120089846431 0.0314242004033866 0.0297480950480665 9692/51367/10557/1787/79902/84705/80324 7 ATL_CD40LG R-HSA-5683057 MAPK family signaling cascades 22/281 293/10554 1.13174343338626e-05 0.00579023019919027 0.00423932956220027 80824/5709/7297/8202/25780/5518/6714/2885/84078/5719/5154/8817/5694/1445/3265/8682/5717/5714/1741/5605/5879/115727 22 ATL_CD40LG R-HSA-5684996 MAPK1/MAPK3 signaling 20/281 254/10554 1.43322529682927e-05 0.00579023019919027 0.00423932956220027 80824/5709/7297/25780/5518/6714/2885/84078/5719/5154/8817/5694/1445/3265/8682/5717/5714/1741/5605/115727 20 ATL_CD40LG R-HSA-5673001 RAF/MAP kinase cascade 19/281 248/10554 3.44475788300741e-05 0.00686438748373754 0.00502577614103765 80824/5709/25780/5518/6714/2885/84078/5719/5154/8817/5694/1445/3265/8682/5717/5714/1741/5605/115727 19 ATL_CD40LG R-HSA-453279 Mitotic G1-G1/S phases 14/281 149/10554 4.22633381527603e-05 0.00686438748373754 0.00502577614103765 5422/5709/7083/5518/6714/1876/5719/993/5694/5717/5714/4173/4171/4174 14 ATL_CD40LG R-HSA-69206 G1/S Transition 13/281 131/10554 4.48808867662644e-05 0.00686438748373754 0.00502577614103765 5422/5709/7083/5518/1876/5719/993/5694/5717/5714/4173/4171/4174 13 ATL_CD40LG R-HSA-69275 G2/M Transition 16/281 194/10554 6.00957672705119e-05 0.00686438748373754 0.00502577614103765 5709/2033/5518/5719/84617/993/51400/5694/11258/5717/5714/5347/8636/203068/10844/1454 16 ATL_CD40LG R-HSA-1257604 PIP3 activates AKT signaling 19/281 260/10554 6.55805711527103e-05 0.00686438748373754 0.00502577614103765 5709/54815/1912/5518/6714/2885/5719/5154/3654/8817/5694/55615/5717/57761/5714/1108/1460/5879/64121 19 ATL_CD40LG R-HSA-453274 Mitotic G2-G2/M phases 16/281 196/10554 6.79642325122529e-05 0.00686438748373754 0.00502577614103765 5709/2033/5518/5719/84617/993/51400/5694/11258/5717/5714/5347/8636/203068/10844/1454 16 ATL_CD40LG R-HSA-8941858 Regulation of RUNX3 expression and activity 8/281 55/10554 9.3896761176848e-05 0.00773426458338446 0.00566265854072703 5709/2033/6714/5719/5694/5717/5714/864 8 ATL_CD40LG R-HSA-186763 Downstream signal transduction 6/281 29/10554 9.57210963290156e-05 0.00773426458338446 0.00566265854072703 6714/2885/5154/2889/3265/1399 6 ATL_CD40LG R-HSA-187687 Signalling to ERKs 6/281 30/10554 0.000117003284050205 0.0085944230465969 0.00629242541973353 6714/2885/2889/3265/9261/1399 6 ATL_CD40LG R-HSA-69481 G2/M Checkpoints 14/281 168/10554 0.000155396610130228 0.0104633717487687 0.00766078025378842 5709/5982/7156/5719/8339/993/8924/5694/5717/9156/5714/4173/4171/4174 14 ATL_CD40LG R-HSA-69190 DNA strand elongation 6/281 32/10554 0.000170753825972011 0.010613007029645 0.00777033604828099 5422/5982/2237/4173/4171/4174 6 ATL_CD40LG R-HSA-389356 CD28 co-stimulation 6/281 33/10554 0.000204086542923885 0.0117787090487499 0.00862380730249801 6714/2885/55615/9020/57761/5879 6 ATL_CD40LG R-HSA-6806834 Signaling by MET 9/281 79/10554 0.000238065359074426 0.0128237873421424 0.0093889636350756 6714/2885/6692/2889/3914/3265/5879/5867/1399 9 ATL_CD40LG R-HSA-9006925 Intracellular signaling by second messengers 19/281 293/10554 0.000311447776025925 0.0153030232519535 0.0112041415680014 5709/54815/1912/5518/6714/2885/5719/5154/3654/8817/5694/55615/5717/57761/5714/1108/1460/5879/64121 19 ATL_CD40LG R-HSA-69239 Synthesis of DNA 11/281 119/10554 0.000323143146411249 0.0153030232519535 0.0112041415680014 5422/5709/5982/5719/5694/2237/5717/5714/4173/4171/4174 11 ATL_CD40LG R-HSA-5633007 Regulation of TP53 Activity 13/281 160/10554 0.000340908933830647 0.0153030232519535 0.0112041415680014 5982/7159/54815/2033/5518/7156/1616/55615/6749/9156/5564/1108/1460 13 ATL_CD40LG R-HSA-5621481 C-type lectin receptors (CLRs) 12/281 142/10554 0.000401382520210955 0.0162705042552357 0.011912484876814 5709/4582/2033/6714/5719/5694/5971/3265/3384/9020/5717/5714 12 ATL_CD40LG R-HSA-69002 DNA Replication Pre-Initiation 9/281 85/10554 0.000414472574632747 0.0162705042552357 0.011912484876814 5422/5709/5719/5694/5717/5714/4173/4171/4174 9 ATL_CD40LG R-HSA-68867 Assembly of the pre-replicative complex 8/281 68/10554 0.00042287201653459 0.0162705042552357 0.011912484876814 5709/5719/5694/5717/5714/4173/4171/4174 8 ATL_CD40LG R-HSA-388841 Costimulation by the CD28 family 8/281 70/10554 0.000515849237568736 0.0189457356343427 0.0138711613164416 5518/6714/2885/1445/55615/9020/57761/5879 8 ATL_CD40LG R-HSA-69306 DNA Replication 11/281 127/10554 0.000565208218939539 0.0191288713387438 0.0140052445184654 5422/5709/5982/5719/5694/2237/5717/5714/4173/4171/4174 11 ATL_CD40LG R-HSA-68949 Orc1 removal from chromatin 8/281 71/10554 0.000568184297190411 0.0191288713387438 0.0140052445184654 5709/5719/5694/5717/5714/4173/4171/4174 8 ATL_CD40LG R-HSA-8875878 MET promotes cell motility 6/281 41/10554 0.000693141760576721 0.0224023417018396 0.0164019229239628 6714/2885/2889/3914/5879/1399 6 ATL_CD40LG R-HSA-186797 Signaling by PDGF 7/281 58/10554 0.000827972765039415 0.0257308459289172 0.0188388944919899 6714/2885/5154/2889/3265/1298/1399 7 ATL_CD40LG R-HSA-5676590 NIK-->noncanonical NF-kB signaling 7/281 59/10554 0.000918434091300941 0.0274849905841171 0.0201231952947808 5709/5719/5694/5971/9020/5717/5714 7 ATL_CD40LG R-HSA-8878159 Transcriptional regulation by RUNX3 9/281 96/10554 0.00101220092960934 0.0283219943169505 0.0207360093878663 5709/2033/6714/5719/5694/5717/5714/182/864 9 ATL_CD40LG R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 7/281 60/10554 0.00101650722177174 0.0283219943169505 0.0207360093878663 5709/5719/5694/5971/9020/5717/5714 7 ATL_CD40LG R-HSA-187037 Signaling by NTRK1 (TRKA) 8/281 78/10554 0.00106682854498568 0.0287332488116144 0.0210371102555072 5518/6714/2885/2889/3265/9261/1211/1399 8 ATL_CD40LG R-HSA-373760 L1CAM interactions 10/281 117/10554 0.00110774034918893 0.0288727161982148 0.0211392216042167 1641/6714/84617/5962/1741/1460/1808/5605/5879/1211 10 ATL_CD40LG R-HSA-69242 S Phase 12/281 161/10554 0.00122768219324966 0.0308763799081894 0.022606208322567 5422/5709/5982/5719/993/5694/2237/5717/5714/4173/4171/4174 12 ATL_CD40LG R-HSA-166520 Signaling by NTRKs 9/281 99/10554 0.00126104026852754 0.0308763799081894 0.022606208322567 5518/6714/2885/2889/3265/9261/5879/1211/1399 9 ATL_CD40LG R-HSA-9013694 Signaling by NOTCH4 8/281 82/10554 0.00148005418099134 0.0351730523012059 0.0257520263070319 5709/2033/5719/5694/5663/5717/5714/182 8 ATL_CD40LG R-HSA-167044 Signalling to RAS 4/281 20/10554 0.00170141454175118 0.0392783699924272 0.0287577435327568 6714/2885/3265/9261 4 ATL_CD40LG R-HSA-5621575 CD209 (DC-SIGN) signaling 4/281 21/10554 0.00205820048508033 0.0460652744942535 0.0337267903410246 2033/5971/3265/3384 4 ATL_CD40LG R-HSA-5658442 Regulation of RAS by GAPs 7/281 68/10554 0.00213034360822175 0.0460652744942535 0.0337267903410246 5709/84078/5719/5694/3265/5717/5714 7 ATL_CD40LG R-HSA-983169 Class I MHC mediated antigen processing & presentation 20/281 371/10554 0.0021750495710984 0.0460652744942535 0.0337267903410246 5709/84078/5719/25831/26118/23014/9871/10333/54850/8924/5694/6047/79654/5717/29927/81559/5714/25898/10075/10616 20 ATL_CD40LG R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 6/281 51/10554 0.00222344765504442 0.0460652744942535 0.0337267903410246 5709/5719/4946/5694/5717/5714 6 ATL_CD40LG R-HSA-69052 Switching of origins to a post-replicative state 8/281 90/10554 0.002682199503962 0.0498018928820184 0.0364625635743803 5709/5719/5694/5717/5714/4173/4171/4174 8 ATL_CD40LG R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 6/281 53/10554 0.00271158194616744 0.0498018928820184 0.0364625635743803 5709/5719/993/5694/5717/5714 6 ATL_CD40LG R-HSA-69610 p53-Independent DNA Damage Response 6/281 53/10554 0.00271158194616744 0.0498018928820184 0.0364625635743803 5709/5719/993/5694/5717/5714 6 ATL_CD40LG R-HSA-69613 p53-Independent G1/S DNA damage checkpoint 6/281 53/10554 0.00271158194616744 0.0498018928820184 0.0364625635743803 5709/5719/993/5694/5717/5714 6 ATL_CD40LG R-HSA-176187 Activation of ATR in response to replication stress 5/281 37/10554 0.00280005458175957 0.0498018928820184 0.0364625635743803 5982/993/4173/4171/4174 5 ATL_CD40LG R-HSA-112409 RAF-independent MAPK1/3 activation 4/281 23/10554 0.00292046003903812 0.0498018928820184 0.0364625635743803 80824/7297/8682/5605 4 ATL_CD40LG R-HSA-446203 Asparagine N-linked glycosylation 17/281 302/10554 0.0029572394500626 0.0498018928820184 0.0364625635743803 10959/54732/4247/8775/5373/11253/23193/5537/55907/9871/84617/29925/11258/79947/1650/10960/1075 17 ATL_CD40LG R-HSA-199992 trans-Golgi Network Vesicle Budding 7/281 72/10554 0.00295852829002089 0.0498018928820184 0.0364625635743803 6272/1777/8775/9829/4074/5878/1211 7 ATL_CD40LG R-HSA-421837 Clathrin derived vesicle budding 7/281 72/10554 0.00295852829002089 0.0498018928820184 0.0364625635743803 6272/1777/8775/9829/4074/5878/1211 7