Supplemental Data

• Supplementary Methods - Detailed description of the fitting procedures for the scaling parameter, melting points, and mean functions of the model.
• Table S1 - Spreadsheet containing the results of the NPARC approach and of the Tm-based approach for all datasets listed in Table 1.
• Supplementary Figures S1-S5 - PDF containing Supplementary Figures S1-S5.
• Supplementary Figure S6 -

  All proteins detected by the NPARC approach with Benjamini-Hochberg adjusted F-test p-values <= 0.01 in the staurosporine data.

• Supplementary Figure S7 -

  All proteins detected by the NPARC approach with Benjamini-Hochberg adjusted F-test p-values <= 0.01 in the ATP data.