{"text_format":"3","workbook":"xlsb","n_sheets":6,"sheets":["Contents","IUPHAR annotated GPCRs","GPCR ligands and linkages","Non-silent Mutations","Mutation Events","GPCR CNV"],"read":"whole","date_system":"1900","formulas":"cached_only","passed_over":{"ids":[37,38,1024],"n":5982}}

{"sheet":"Contents","index":0,"n_rows":13,"n_cols":4,"rows_kept":13,"flags":["formulas_cached_only"]}
[{"$nulls":3},"Sriram K, Moyung K, Corriden R, Carter H and Insel PA. GPCRs show widespread differential mRNA expression and frequent mutation and copy number variation in solid tumors "]
[]
[null,"Sheet","Contents","Notes"]
[]
[null,2,"IUPHAR annotated GPCRs","A list of IUPHAR annotated GPCRs inlcluded in DE analysis presented in this study, along with corresponding aliases used for mutation and CNV analysis"]
[null,3,"GPCR ligands and linkages","Based primarily on data from IUPHAR/BJP, gives which G-alpha these GPCRs generally signal through, plus an example of an endogenous ligand"]
[null,4,"Non-silent Mutations","Number of Tumors that have a GPCR which shows somatic, non-silent mutations, for each tumor type"]
[null,5,"Mutation Events","The number and type of somatic mutation events occurring in GPCR genes, for each tumor type"]
[null,6,"GPCR CNV","GISTIC 2.0 thresholded values for the degree of CNV among GPCRs, for each tumor type"]
[]
[]
[{"$nulls":3},"Data for GPCR mutation and CNV in each individual tumor can be found at insellab.github.io"]
[{"$nulls":3},"All such data were orignially queried from Xena (xena.ucsc.edu) and subsequently annotated and organized to highlight GPCRs"]

{"sheet":"IUPHAR annotated GPCRs","index":1,"n_rows":406,"n_cols":5,"rows_kept":406,"flags":["formulas_cached_only"]}
[null,"IUPHAR Annotated GPCRs included in this study","Hg19 Synonym, used for analysis of mutations","Gene Symbol on CNV Arrays"]
[null,"ACKR1","DARC","DARC"]
[null,"ACKR2","CCBP2","ACKR2"]
[null,"ACKR3","CXCR7","ACKR3"]
[null,"ACKR4","CCRL1","ACKR4"]
[null,"ADCYAP1R1","ADCYAP1R1","ADCYAP1R1"]
[null,"ADGRA1","GPR123","GPR123"]
[null,"ADGRA2","GPR124","GPR124"]
[null,"ADGRA3","GPR125","GPR125"]
[null,"ADGRB1","BAI1","BAI1"]
[null,"ADGRB2","BAI2","BAI2"]
[null,"ADGRB3","BAI3","BAI3"]
[null,"ADGRD1","GPR133","GPR133"]
[null,"ADGRE1","EMR1","EMR1"]
[null,"ADGRE2","EMR2","EMR2"]
[null,"ADGRE3","EMR3","EMR3"]
[null,"ADGRE5","CD97","CD97"]
[null,"ADGRF1","GPR110","GPR110"]
[null,"ADGRF2","GPR111","GPR111"]
[null,"ADGRF3","GPR113","GPR113"]
[null,"ADGRF4","GPR115","GPR115"]
[null,"ADGRF5","GPR116","GPR116"]
[null,"ADGRG1","GPR56","GPR56"]
[null,"ADGRG2","GPR64","GPR64"]
[null,"ADGRG3","GPR97","GPR97"]
[null,"ADGRG4","GPR112","GPR112"]
[null,"ADGRG5","GPR114","GPR114"]
[null,"ADGRG6","GPR126","GPR126"]
[null,"ADGRG7","GPR128","GPR128"]
[null,"ADGRL1","LPHN1","LPHN1"]
[null,"ADGRL2","LPHN2","LPHN2"]
[null,"ADGRL3","LPHN3","LPHN3"]
[null,"ADGRL4","ELTD1","ELTD1"]
[null,"ADGRV1","GPR98","GPR98"]
[null,"ADORA1","ADORA1","ADORA1"]
[null,"ADORA2A","ADORA2A","ADORA2A"]
[null,"ADORA2B","ADORA2B","ADORA2B"]
[null,"ADORA3","ADORA3","ADORA3"]
[null,"ADRA1A","ADRA1A","ADRA1A"]
[null,"ADRA1B","ADRA1B","ADRA1B"]
[null,"ADRA1D","ADRA1D","ADRA1D"]
[null,"ADRA2A","ADRA2A","ADRA2A"]
[null,"ADRA2B","ADRA2B","ADRA2B"]
[null,"ADRA2C","ADRA2C","ADRA2C"]
[null,"ADRB1","ADRB1","ADRB1"]
[null,"ADRB2","ADRB2","ADRB2"]
[null,"ADRB3","ADRB3","ADRB3"]
[null,"AGTR1","AGTR1","AGTR1"]
[null,"AGTR2","AGTR2","AGTR2"]
[null,"APLNR","APLNR","APLNR"]
[null,"AVPR1A","AVPR1A","AVPR1A"]
[null,"AVPR1B","AVPR1B","AVPR1B"]
[null,"AVPR2","AVPR2","AVPR2"]
[null,"BDKRB1","BDKRB1","BDKRB1"]
[null,"BDKRB2","BDKRB2","BDKRB2"]
[null,"BRS3","BRS3","BRS3"]
[null,"C3AR1","C3AR1","C3AR1"]
[null,"C5AR1","C5AR1","C5AR1"]
[null,"C5AR2","C5AR2","C5AR2"]
[null,"CALCR","CALCR","CALCR"]
[null,"CALCRL","CALCRL","CALCRL"]
[null,"CASR","CASR","CASR"]
[null,"CCKAR","CCKAR","CCKAR"]
[null,"CCKBR","CCKBR","CCKBR"]
[null,"CCR1","CCR1","CCR1"]
[null,"CCR10","CCR10","CCR10"]
[null,"CCR2","CCR2","CCR2"]
[null,"CCR3","CCR3","CCR3"]
[null,"CCR4","CCR4","CCR4"]
[null,"CCR5","CCR5","CCR5"]
[null,"CCR6","CCR6","CCR6"]
[null,"CCR7","CCR7","CCR7"]
[null,"CCR8","CCR8","CCR8"]
[null,"CCR9","CCR9","CCR9"]
[null,"CCRL2","CCRL2","ACKR5"]
[null,"CELSR1","CELSR1","CELSR1"]
[null,"CELSR2","CELSR2","CELSR2"]
[null,"CELSR3","CELSR3","CELSR3"]
[null,"CHRM1","CHRM1","CHRM1"]
[null,"CHRM2","CHRM2","CHRM2"]
[null,"CHRM3","CHRM3","CHRM3"]
[null,"CHRM4","CHRM4","CHRM4"]
[null,"CHRM5","CHRM5","CHRM5"]
[null,"CMKLR1","CMKLR1","CMKLR1"]
[null,"CNR1","CNR1","CNR1"]
[null,"CNR2","CNR2","CNR2"]
[null,"CRHR1","CRHR1","CRHR1"]
[null,"CRHR2","CRHR2","CRHR2"]
[null,"CX3CR1","CX3CR1","CX3CR1"]
[null,"CXCR1","CXCR1","CXCR1"]
[null,"CXCR2","CXCR2","CXCR2"]
[null,"CXCR3","CXCR3","CXCR3"]
[null,"CXCR4","CXCR4","CXCR4"]
[null,"CXCR5","CXCR5","CXCR5"]
[null,"CXCR6","CXCR6","CXCR6"]
[null,"CYSLTR1","CYSLTR1","CYSLTR1"]
[null,"CYSLTR2","CYSLTR2","CYSLTR2"]
[null,"DRD1","DRD1","DRD1"]
[null,"DRD2","DRD2","DRD2"]
[null,"DRD3","DRD3","DRD3"]
[null,"DRD4","DRD4","DRD4"]
[null,"DRD5","DRD5","DRD5"]
[null,"EDNRA","EDNRA","EDNRA"]
[null,"EDNRB","EDNRB","EDNRB"]
[null,"F2R","F2R","F2R"]
[null,"F2RL1","F2RL1","F2RL1"]
[null,"F2RL2","F2RL2","F2RL2"]
[null,"F2RL3","F2RL3","F2RL3"]
[null,"FFAR1","FFAR1","FFAR1"]
[null,"FFAR2","FFAR2","FFAR2"]
[null,"FFAR3","FFAR3","FFAR3"]
[null,"FFAR4","FFAR4","FFAR4"]
[null,"FPR1","FPR1","FPR1"]
[null,"FPR2","FPR2","FPR2"]
[null,"FPR3","FPR3","FPR3"]
[null,"FSHR","FSHR","FSHR"]
[null,"FZD1","FZD1","FZD1"]
[null,"FZD10","FZD10","FZD10"]
[null,"FZD2","FZD2","FZD2"]
[null,"FZD3","FZD3","FZD3"]
[null,"FZD4","FZD4","FZD4"]
[null,"FZD5","FZD5","FZD5"]
[null,"FZD6","FZD6","FZD6"]
[null,"FZD7","FZD7","FZD7"]
[null,"FZD8","FZD8","FZD8"]
[null,"FZD9","FZD9","FZD9"]
[null,"GABBR1","GABBR1","GABBR1"]
[null,"GABBR2","GABBR2","GABBR2"]
[null,"GALR1","GALR1","GALR1"]
[null,"GALR2","GALR2","GALR2"]
[null,"GALR3","GALR3","GALR3"]
[null,"GCGR","GCGR","GCGR"]
[null,"GHRHR","GHRHR","GHRHR"]
[null,"GHSR","GHSR","GHSR"]
[null,"GIPR","GIPR","GIPR"]
[null,"GLP1R","GLP1R","GLP1R"]
[null,"GLP2R","GLP2R","GLP2R"]
[null,"GNRHR","GNRHR","GNRHR"]
[null,"GNRHR2","GNRHR2","GNRHR2"]
[null,"GPBAR1","GPBAR1","GPBAR1"]
[null,"GPER1","GPER","GPER"]
[null,"GPR1","GPR1","GPR1"]
[null,"GPR101","GPR101","GPR101"]
[null,"GPR107","GPR107","GPR107"]
[null,"GPR119","GPR119","GPR119"]
[null,"GPR12","GPR12","GPR12"]
[null,"GPR132","GPR132","GPR132"]
[null,"GPR135","GPR135","GPR135"]
[null,"GPR137","GPR137","GPR137"]
[null,"GPR139","GPR139","GPR139"]
[null,"GPR141","GPR141","GPR141"]
[null,"GPR142","GPR142","GPR142"]
[null,"GPR143","GPR143","GPR143"]
[null,"GPR146","GPR146","GPR146"]
[null,"GPR148","GPR148","GPR148"]
[null,"GPR149","GPR149","GPR149"]
[null,"GPR15","GPR15","GPR15"]
[null,"GPR150","GPR150","GPR150"]
[null,"GPR151","GPR151","GPR151"]
[null,"GPR152","GPR152","GPR152"]
[null,"GPR153","GPR153","GPR153"]
[null,"GPR156","GPR156","GPR156"]
[null,"GPR157","GPR157","GPR157"]
[null,"GPR158","GPR158","GPR158"]
[null,"GPR160","GPR160","GPR160"]
[null,"GPR161","GPR161","GPR161"]
[null,"GPR162","GPR162","GPR162"]
[null,"GPR17","GPR17","GPR17"]
[null,"GPR171","GPR171","GPR171"]
[null,"GPR173","GPR173","GPR173"]
[null,"GPR174","GPR174","GPR174"]
[null,"GPR176","GPR176","GPR176"]
[null,"GPR179","GPR179","GPR179"]
[null,"GPR18","GPR18","GPR18"]
[null,"GPR182","GPR182","GPR182"]
[null,"GPR183","GPR183","GPR183"]
[null,"GPR19","GPR19","GPR19"]
[null,"GPR20","GPR20","GPR20"]
[null,"GPR21","GPR21","GPR21"]
[null,"GPR22","GPR22","GPR22"]
[null,"GPR25","GPR25","GPR25"]
[null,"GPR26","GPR26","GPR26"]
[null,"GPR27","GPR27","GPR27"]
[null,"GPR3","GPR3","GPR3"]
[null,"GPR31","GPR31","GPR31"]
[null,"GPR32","GPR32","GPR32"]
[null,"GPR33","GPR33","GPR33"]
[null,"GPR34","GPR34","GPR34"]
[null,"GPR35","GPR35","GPR35"]
[null,"GPR37","GPR37","GPR37"]
[null,"GPR37L1","GPR37L1","GPR37L1"]
[null,"GPR39","GPR39","GPR39"]
[null,"GPR4","GPR4","GPR4"]
[null,"GPR45","GPR45","GPR45"]
[null,"GPR50","GPR50","GPR50"]
[null,"GPR52","GPR52","GPR52"]
[null,"GPR55","GPR55","GPR55"]
[null,"GPR6","GPR6","GPR6"]
[null,"GPR61","GPR61","GPR61"]
[null,"GPR62","GPR62","GPR62"]
[null,"GPR63","GPR63","GPR63"]
[null,"GPR65","GPR65","GPR65"]
[null,"GPR68","GPR68","GPR68"]
[null,"GPR75","GPR75","GPR75"]
[null,"GPR78","GPR78","GPR78"]
[null,"GPR82","GPR82","GPR82"]
[null,"GPR83","GPR83","GPR83"]
[null,"GPR84","GPR84","GPR84"]
[null,"GPR85","GPR85","GPR85"]
[null,"GPR87","GPR87","GPR87"]
[null,"GPR88","GPR88","GPR88"]
[null,"GPRC5A","GPRC5A","GPRC5A"]
[null,"GPRC5B","GPRC5B","GPRC5B"]
[null,"GPRC5C","GPRC5C","GPRC5C"]
[null,"GPRC5D","GPRC5D","GPRC5D"]
[null,"GPRC6A","GPRC6A","GPRC6A"]
[null,"GRM1","GRM1","GRM1"]
[null,"GRM2","GRM2","GRM2"]
[null,"GRM3","GRM3","GRM3"]
[null,"GRM4","GRM4","GRM4"]
[null,"GRM5","GRM5","GRM5"]
[null,"GRM6","GRM6","GRM6"]
[null,"GRM7","GRM7","GRM7"]
[null,"GRM8","GRM8","GRM8"]
[null,"GRPR","GRPR","GRPR"]
[null,"HCAR1","HCAR1","HCAR1"]
[null,"HCAR2","HCAR2","HCAR2"]
[null,"HCAR3","HCAR3","HCAR3"]
[null,"HCRTR1","HCRTR1","HCRTR1"]
[null,"HCRTR2","HCRTR2","HCRTR2"]
[null,"HRH1","HRH1","HRH1"]
[null,"HRH2","HRH2","HRH2"]
[null,"HRH3","HRH3","HRH3"]
[null,"HRH4","HRH4","HRH4"]
[null,"HTR1A","HTR1A","HTR1A"]
[null,"HTR1B","HTR1B","HTR1B"]
[null,"HTR1D","HTR1D","HTR1D"]
[null,"HTR1E","HTR1E","HTR1E"]
[null,"HTR1F","HTR1F","HTR1F"]
[null,"HTR2A","HTR2A","HTR2A"]
[null,"HTR2B","HTR2B","HTR2B"]
[null,"HTR2C","HTR2C","HTR2C"]
[null,"HTR4","HTR4","HTR4"]
[null,"HTR5A","HTR5A","HTR5A"]
[null,"HTR6","HTR6","HTR6"]
[null,"HTR7","HTR7","HTR7"]
[null,"KISS1R","KISS1R","KISS1R"]
[null,"LGR4","LGR4","LGR4"]
[null,"LGR5","LGR5","LGR5"]
[null,"LGR6","LGR6","LGR6"]
[null,"LHCGR","LHCGR","LHCGR"]
[null,"LPAR1","LPAR1","LPAR1"]
[null,"LPAR2","LPAR2","LPAR2"]
[null,"LPAR3","LPAR3","LPAR3"]
[null,"LPAR4","LPAR4","LPAR4"]
[null,"LPAR5","LPAR5","LPAR5"]
[null,"LPAR6","LPAR6","LPAR6"]
[null,"LTB4R","LTB4R","LTB4R"]
[null,"LTB4R2","LTB4R2","LTB4R2"]
[null,"MAS1","MAS1","MAS1"]
[null,"MAS1L","MAS1L","MAS1L"]
[null,"MC1R","MC1R","MC1R"]
[null,"MC2R","MC2R","MC2R"]
[null,"MC3R","MC3R","MC3R"]
[null,"MC4R","MC4R","MC4R"]
[null,"MC5R","MC5R","MC5R"]
[null,"MCHR1","MCHR1","MCHR1"]
[null,"MCHR2","MCHR2","MCHR2"]
[null,"MLNR","MLNR","MLNR"]
[null,"MRGPRD","MRGPRD","MRGPRD"]
[null,"MRGPRE","MRGPRE","MRGPRE"]
[null,"MRGPRF","MRGPRF","MRGPRF"]
[null,"MRGPRG","MRGPRG","MRGPRG"]
[null,"MRGPRX1","MRGPRX1","MRGPRX1"]
[null,"MRGPRX2","MRGPRX2","MRGPRX2"]
[null,"MRGPRX3","MRGPRX3","MRGPRX3"]
[null,"MRGPRX4","MRGPRX4","MRGPRX4"]
[null,"MTNR1A","MTNR1A","MTNR1A"]
[null,"MTNR1B","MTNR1B","MTNR1B"]
[null,"NMBR","NMBR","NMBR"]
[null,"NMUR1","NMUR1","NMUR1"]
[null,"NMUR2","NMUR2","NMUR2"]
[null,"NPBWR1","NPBWR1","NPBWR1"]
[null,"NPBWR2","NPBWR2","NPBWR2"]
[null,"NPFFR1","NPFFR1","NPFFR1"]
[null,"NPFFR2","NPFFR2","NPFFR2"]
[null,"NPSR1","NPSR1","NPSR1"]
[null,"NPY1R","NPY1R","NPY1R"]
[null,"NPY2R","NPY2R","NPY2R"]
[null,"NPY4R","NPY4R","NPY4R"]
[null,"NPY5R","NPY5R","NPY5R"]
[null,"NPY6R","NPY6R","NPY6R"]
[null,"NTSR1","NTSR1","NTSR1"]
[null,"NTSR2","NTSR2","NTSR2"]
[null,"OPN3","OPN3","OPN3"]
[null,"OPN4","OPN4","OPN4"]
[null,"OPN5","OPN5","OPN5"]
[null,"OPRD1","OPRD1","OPRD1"]
[null,"OPRK1","OPRK1","OPRK1"]
[null,"OPRL1","OPRL1","OPRL1"]
[null,"OPRM1","OPRM1","OPRM1"]
[null,"OR51E1","OR51E1","OR51E1"]
[null,"OXER1","OXER1","OXER1"]
[null,"OXGR1","OXGR1","OXGR1"]
[null,"OXTR","OXTR","OXTR"]
[null,"P2RY1","P2RY1","P2RY1"]
[null,"P2RY10","P2RY10","P2RY10"]
[null,"P2RY11","P2RY11","P2RY11"]
[null,"P2RY12","P2RY12","P2RY12"]
[null,"P2RY13","P2RY13","P2RY13"]
[null,"P2RY14","P2RY14","P2RY14"]
[null,"P2RY2","P2RY2","P2RY2"]
[null,"P2RY4","P2RY4","P2RY4"]
[null,"P2RY6","P2RY6","P2RY6"]
[null,"P2RY8","P2RY8","P2RY8"]
[null,"PRLHR","PRLHR","PRLHR"]
[null,"PROKR1","PROKR1","PROKR1"]
[null,"PROKR2","PROKR2","PROKR2"]
[null,"PTAFR","PTAFR","PTAFR"]
[null,"PTGDR","PTGDR","PTGDR"]
[null,"PTGDR2","PTGDR2","PTGDR2"]
[null,"PTGER1","PTGER1","PTGER1"]
[null,"PTGER2","PTGER2","PTGER2"]
[null,"PTGER3","PTGER3","PTGER3"]
[null,"PTGER4","PTGER4","PTGER4"]
[null,"PTGFR","PTGFR","PTGFR"]
[null,"PTGIR","PTGIR","PTGIR"]
[null,"PTH1R","PTH1R","PTH1R"]
[null,"PTH2R","PTH2R","PTH2R"]
[null,"QRFPR","QRFPR","QRFPR"]
[null,"RXFP1","RXFP1","RXFP1"]
[null,"RXFP2","RXFP2","RXFP2"]
[null,"RXFP3","RXFP3","RXFP3"]
[null,"RXFP4","RXFP4","RXFP4"]
[null,"S1PR1","S1PR1","S1PR1"]
[null,"S1PR2","S1PR2","S1PR2"]
[null,"S1PR3","S1PR3","S1PR3"]
[null,"S1PR4","S1PR4","S1PR4"]
[null,"S1PR5","S1PR5","S1PR5"]
[null,"SCTR","SCTR","SCTR"]
[null,"SMO","SMO","SMO"]
[null,"SSTR1","SSTR1","SSTR1"]
[null,"SSTR2","SSTR2","SSTR2"]
[null,"SSTR3","SSTR3","SSTR3"]
[null,"SSTR4","SSTR4","SSTR4"]
[null,"SSTR5","SSTR5","SSTR5"]
[null,"SUCNR1","SUCNR1","SUCNR1"]
[null,"TAAR1","TAAR1","TAAR1"]
[null,"TAAR2","TAAR2","TAAR2"]
[null,"TAAR3","TAAR3","TAAR3","* likely pseudogene in humans, but was included in analysis"]
[null,"TAAR5","TAAR5","TAAR5"]
[null,"TAAR6","TAAR6","TAAR6"]
[null,"TAAR8","TAAR8","TAAR8"]
[null,"TAAR9","TAAR9","TAAR9"]
[null,"TACR1","TACR1","TACR1"]
[null,"TACR2","TACR2","TACR2"]
[null,"TACR3","TACR3","TACR3"]
[null,"TAS1R1","TAS1R1","TAS1R1"]
[null,"TAS1R2","TAS1R2","TAS1R2"]
[null,"TAS1R3","TAS1R3","TAS1R3"]
[null,"TAS2R1","TAS2R1","TAS2R1"]
[null,"TAS2R10","TAS2R10","TAS2R10"]
[null,"TAS2R13","TAS2R13","TAS2R13"]
[null,"TAS2R14","TAS2R14","TAS2R14"]
[null,"TAS2R16","TAS2R16","TAS2R16"]
[null,"TAS2R19","TAS2R19","TAS2R19"]
[null,"TAS2R20","TAS2R20","TAS2R20"]
[null,"TAS2R3","TAS2R3","TAS2R3"]
[null,"TAS2R30","TAS2R30","TAS2R30"]
[null,"TAS2R31","TAS2R31","TAS2R31"]
[null,"TAS2R38","TAS2R38","TAS2R38"]
[null,"TAS2R39","TAS2R39","TAS2R39"]
[null,"TAS2R4","TAS2R4","TAS2R4"]
[null,"TAS2R40","TAS2R40","TAS2R40"]
[null,"TAS2R41","TAS2R41","TAS2R41"]
[null,"TAS2R42","TAS2R42","TAS2R42"]
[null,"TAS2R43","TAS2R43","TAS2R43"]
[null,"TAS2R46","TAS2R46","TAS2R46"]
[null,"TAS2R5","TAS2R5","TAS2R5"]
[null,"TAS2R50","TAS2R50","TAS2R50"]
[null,"TAS2R60","TAS2R60","TAS2R60"]
[null,"TAS2R7","TAS2R7","TAS2R7"]
[null,"TAS2R8","TAS2R8","TAS2R8"]
[null,"TAS2R9","TAS2R9","TAS2R9"]
[null,"TBXA2R","TBXA2R","TBXA2R"]
[null,"TPRA1","TPRA1","TPRA1"]
[null,"TRHR","TRHR","TRHR"]
[null,"TSHR","TSHR","TSHR"]
[null,"UTS2R","UTS2R","UTS2R"]
[null,"VIPR1","VIPR1","VIPR1"]
[null,"VIPR2","VIPR2","VIPR2"]
[null,"XCR1","XCR1","XCR1"]
[]
[]
[]
[null,"IUPHAR annotated GPCRs not included in this analysis"]
[]
[]
[null,"ADGRD2",null,null,"* dubious annotation, not a validated protein coding gene, at least per Refseq. No available references desribing presence as functional protein."]
[null,"ADGRE4P",null,null,"*pseudogene"]
[null,"GPR42",null,null,"*pseudogene"]
[null,"GPR42",null,null,"*pseudogene"]
[null,"GPR79",null,null,"*pseudogene"]
[null,"HTR5BP",null,null,"*pseudogene in humans"]
[null,"TAAR4P",null,null,"*pseudogene"]
[null,"TAS2R45",null,null,"*Classified as pseudogene per ensembl"]

{"sheet":"GPCR ligands and linkages","index":2,"n_rows":392,"n_cols":4,"rows_kept":392,"flags":["formulas_cached_only"]}
[null,"IUPHAR Annotated GPCRs considered in this study","Example of an Endogenous Ligand (if known) or if the GPCR is an orphan","Primary G protein Linkage"]
[null,"ACKR1","CXCL5","Unknown"]
[null,"ACKR2","CCL2","Unknown"]
[null,"ACKR3","CXCL11","Unknown"]
[null,"ACKR4","CCL19","Unknown"]
[null,"ADCYAP1R1","PACAP-27","Gs"]
[null,"ADGRA1","Orphan","Unknown"]
[null,"ADGRA2","GAGs","Unknown"]
[null,"ADGRA3","Orphan","Unknown"]
[null,"ADGRB1","phosphatidylserine","Unknown"]
[null,"ADGRB2","Orphan","Unknown"]
[null,"ADGRB3","Orphan","Unknown"]
[null,"ADGRD1","Orphan","Gs"]
[null,"ADGRE1","Orphan","Unknown"]
[null,"ADGRE2","Orphan","Gq/G11"]
[null,"ADGRE3","Orphan","Unknown"]
[null,"ADGRE5","Orphan","G12/13"]
[null,"ADGRF1","Synaptamide","Gs"]
[null,"ADGRF2","Orphan","Unknown"]
[null,"ADGRF3","Orphan","Unknown"]
[null,"ADGRF4","Orphan","Gq/G11"]
[null,"ADGRF5","Orphan","Gq/G11"]
[null,"ADGRG1","COL3A1","Gq/G11, G12/G13"]
[null,"ADGRG2","Orphan","Gs"]
[null,"ADGRG3","Orphan","Gi/Go"]
[null,"ADGRG4","Orphan","Unknown"]
[null,"ADGRG5","Orphan","Unknown"]
[null,"ADGRG6","Collagen IV","Gs"]
[null,"ADGRG7","Orphan","Unknown"]
[null,"ADGRL1","Orphan","Gq/G11"]
[null,"ADGRL2","Orphan","Unknown"]
[null,"ADGRL3","Orphan","Unknown"]
[null,"ADGRL4","Orphan","Unknown"]
[null,"ADGRV1","Orphan","Unknown"]
[null,"ADORA1","adenosine","Gi/Go"]
[null,"ADORA2A","adenosine","Gs"]
[null,"ADORA2B","adenosine","Gs"]
[null,"ADORA3","adenosine","Gi/Go"]
[null,"ADRA1A","(-)-adrenaline","Gq/G11"]
[null,"ADRA1B","(-)-adrenaline","Gq/G11"]
[null,"ADRA1D","(-)-adrenaline","Gq/G11"]
[null,"ADRA2A","(-)-adrenaline","Gi/Go"]
[null,"ADRA2B","(-)-noradrenaline","Gi/Go"]
[null,"ADRA2C","(-)-adrenaline","Gi/Go"]
[null,"ADRB1","noradrenaline","Gs"]
[null,"ADRB2","(-)-adrenaline","Gs"]
[null,"ADRB3","(-)-noradrenaline","Gs"]
[null,"AGTR1","angiotensin A","Gi/Go, Gq/G11"]
[null,"AGTR2","angiotensin II","Gi/Go"]
[null,"APLNR","apelin-36 ","Gi/Go"]
[null,"AVPR1A","arginine vasotocin","Gq/G11"]
[null,"AVPR1B","arginine vasotocin","Gq/G11"]
[null,"AVPR2","arginine vasotocin","Gs"]
[null,"BDKRB1","bradykinin","Gi/Go, Gq/G11"]
[null,"BDKRB2","bradykinin","Gs, Gi/Go, Gq/G11"]
[null,"BRS3","Orphan","Gq/G11"]
[null,"C3AR1","C3a","Unknown"]
[null,"C5AR1","C5a","Gi/Go"]
[null,"C5AR2","C5a","Unknown"]
[null,"CALCR","adrenomedullin","Gs"]
[null,"CALCRL","adrenomedullin","Gs"]
[null,"CASR","Ca<sup>2+</sup>","Gi/Go, Gq/G11, G12/G13"]
[null,"CCKAR","CCK-8","Gq/G11"]
[null,"CCKBR","desulfated gastrin-14","Gq/G11"]
[null,"CCR1","CCL13","Gi/Go"]
[null,"CCR10","CCL27","Gi/Go"]
[null,"CCR2","CCL24","Gi/Go"]
[null,"CCR3","CXCL10","Gi/Go"]
[null,"CCR4","CCL17","Gi/Go"]
[null,"CCR5","CCL7","Gi/Go"]
[null,"CCR6","beta-defensin 4A","Gi/Go"]
[null,"CCR7","CCL19","Gi/Go"]
[null,"CCR8","CCL1","Gi/Go"]
[null,"CCR9","CCL25","Gi/Go"]
[null,"CCRL2","CCL19","Unknown"]
[null,"CELSR1","Orphan","G12/13"]
[null,"CELSR2","Orphan","Unknown"]
[null,"CELSR3","Orphan","Unknown"]
[null,"CHRM1","acetylcholine","Gq/G11"]
[null,"CHRM2","acetylcholine","Gi/Go"]
[null,"CHRM3","acetylcholine","Gq/G11"]
[null,"CHRM4","acetylcholine","Gi/Go"]
[null,"CHRM5","acetylcholine","Gq/G11"]
[null,"CMKLR1","chemerin","Gi/Go"]
[null,"CNR1","anandamide","Gi/Go"]
[null,"CNR2","2-arachidonoylglycerol","Gi/Go"]
[null,"CRHR1","corticotrophin-releasing hormone","Gs"]
[null,"CRHR2","corticotrophin-releasing hormone","Gs"]
[null,"CX3CR1","CX<sub>3</sub>CL1","Gi/Go"]
[null,"CXCR1","CXCL1 ","Gi/Go"]
[null,"CXCR2","CXCL1 ","Gi/Go"]
[null,"CXCR3","CCL11","Gi/Go"]
[null,"CXCR4","CXCL12&delta;","Gi/Go"]
[null,"CXCR5","CXCL13 ","Gi/Go"]
[null,"CXCR6","CXCL16","Gi/Go"]
[null,"CYSLTR1","LTC<sub>4</sub>","Gq/G11"]
[null,"CYSLTR2","LTC<sub>4</sub>","Gq/G11"]
[null,"DRD1","dopamine","Gs"]
[null,"DRD2","dopamine","Gi/Go"]
[null,"DRD3","dopamine","Gi/Go"]
[null,"DRD4","dopamine","Gi/Go"]
[null,"DRD5","5-hydroxytryptamine","Gs"]
[null,"EDNRA","endothelin-1","Gq/G11"]
[null,"EDNRB","endothelin-3","Gs, Gi/Go, Gq/G11"]
[null,"F2R","thrombin","Gi/Go, Gq/G11, G12/G13"]
[null,"F2RL1","trypsin","Gi/Go"]
[null,"F2RL2","thrombin","Unknown"]
[null,"F2RL3","thrombin","Gq/G11. G12/13"]
[null,"FFAR1","free fatty acids","Gq/G11"]
[null,"FFAR2","free fatty acids","Gq/G11"]
[null,"FFAR3","free fatty acids","Gi/Go"]
[null,"FFAR4","free fatty acids","Gq/G11"]
[null,"FPR1","annexin 1","Gi/Go"]
[null,"FPR2","annexin 1","Gi/Go"]
[null,"FPR3","F2L","Gi/Go"]
[null,"FSHR","Orphan","Gs"]
[null,"FZD1","Wnt","Gi/Go, Gq/G11"]
[null,"FZD10","Wnt","Unknown"]
[null,"FZD2","Wnt-5a","Gi/Go"]
[null,"FZD3","Wnt-3a","Gs"]
[null,"FZD4","norrin","G12/G13"]
[null,"FZD5","Wnt","Unknown"]
[null,"FZD6","Wnt-3a","Gi/Go, Gq/G11"]
[null,"FZD7","Wnt","Gs, Gi/Go"]
[null,"FZD8","Wnt","Unknown"]
[null,"FZD9","Wnt","Unknown"]
[null,"GABBR1","GABA","Unknown"]
[null,"GABBR2","Orphan","Unknown"]
[null,"GALR1","galanin","Gi/Go"]
[null,"GALR2","[<sup>125</sup>I][Tyr<sup>26</sup>]galanin (human)","Gq/G11"]
[null,"GALR3","galanin","Gi/Go"]
[null,"GCGR","glucagon","Gs"]
[null,"GHRHR","Glucagon","Gs"]
[null,"GHSR","ghrelin","Gq/G11"]
[null,"GIPR","gastric inhibitory polypeptide","Gs"]
[null,"GLP1R","glucagon","Gs"]
[null,"GLP2R","glucagon-like peptide 2","Gs"]
[null,"GNRHR","GnRH I","Gq/G11"]
[null,"GNRHR2","GnRH I and II","Unknown"]
[null,"GPBAR1","chenodeoxycholic acid","Gs"]
[null,"GPER1","17β-estradiol","Gi/Go"]
[null,"GPR1","chemerin","Unknown"]
[null,"GPR101","Orphan","Gs"]
[null,"GPR107","neuronostatin","Unknown"]
[null,"GPR119","N-oleoylethanolamide","Gs"]
[null,"GPR12","sphingosine 1-phosphate","Gs, Gi/Go"]
[null,"GPR132","Protons","Gs, Gq, G12/13"]
[null,"GPR135","Orphan","Unknown"]
[null,"GPR137","Orphan","Gq/G12"]
[null,"GPR139","Orphan","Gq/G11"]
[null,"GPR141","Orphan","Unknown"]
[null,"GPR142","Orphan","Unknown"]
[null,"GPR143","levodopa","Unknown"]
[null,"GPR146","Orphan","Unknown"]
[null,"GPR148","Orphan","Unknown"]
[null,"GPR149","Orphan","Unknown"]
[null,"GPR15","Orphan","Unknown"]
[null,"GPR150","Orphan","Unknown"]
[null,"GPR151","galanin","Unknown"]
[null,"GPR152","Orphan","Unknown"]
[null,"GPR153","Orphan","Unknown"]
[null,"GPR156","Orphan","Unknown"]
[null,"GPR157","Orphan","Unknown"]
[null,"GPR158","Orphan","Unknown"]
[null,"GPR160","Orphan","Unknown"]
[null,"GPR161","Orphan","Unknown"]
[null,"GPR162","Orphan","Unknown"]
[null,"GPR17","ATP","Gi/Go"]
[null,"GPR171","BigLEN","Gi/Go"]
[null,"GPR173","Orphan","Unknown"]
[null,"GPR174","lysophosphatidylserine","Gs, G12/13"]
[null,"GPR176","Orphan","Unknown"]
[null,"GPR179","Orphan","Unknown"]
[null,"GPR18","N-arachidonoylglycine","Gi/Go, Gq/G11"]
[null,"GPR182","Orphan","Unknown"]
[null,"GPR183","25-dihydroxycholesterol","Gi/Go"]
[null,"GPR19","Orphan","Unknown"]
[null,"GPR20","Orphan","Gi/Go"]
[null,"GPR21","Orphan","Gq/G11"]
[null,"GPR22","Orphan","Gi/Go"]
[null,"GPR25","Orphan","Unknown"]
[null,"GPR26","Orphan","Gs"]
[null,"GPR27","Orphan","Gq/G11"]
[null,"GPR3","sphingosine 1-phosphate","Gs"]
[null,"GPR31","Orphan","Gi/Go"]
[null,"GPR32","Resolvin","Unknown"]
[null,"GPR33","Orphan","Gi/Go"]
[null,"GPR34","lysophosphatidylserine","Gi/Go"]
[null,"GPR35","2-oleoyl-LPA","Unknown"]
[null,"GPR37","prosaptide","Gi/Go"]
[null,"GPR37L1","prosaptide","Gi/Go"]
[null,"GPR39","Zn<sup>2+</sup>","Gq/G11"]
[null,"GPR4","Protons","Gs, Gi/Go, Gq/G11, G12/G13"]
[null,"GPR45","Orphan","Unknown"]
[null,"GPR50","Orphan","Unknown"]
[null,"GPR52","Orphan","Unknown"]
[null,"GPR55","2-arachidonoylglycerol","Gq/G11, G12/G13"]
[null,"GPR6","dihydrosphingosine-1-phosphate","Gs, Gi/Go"]
[null,"GPR61","Orphan","Unknown"]
[null,"GPR62","Orphan","Unknown"]
[null,"GPR63","dihydrosphingosine-1-phosphate","Unknown"]
[null,"GPR65","Protons","Gs"]
[null,"GPR68","Protons","Gi/Go, Gq/G11"]
[null,"GPR75","CCL5","Gq/G11"]
[null,"GPR78","Orphan","Gs"]
[null,"GPR82","Orphan","Unknown"]
[null,"GPR83","Orphan","Unknown"]
[null,"GPR84","Orphan","Gi/Go"]
[null,"GPR85","Orphan","Unknown"]
[null,"GPR87","LPA","Unknown"]
[null,"GPR88","Orphan","Unknown"]
[null,"GPRC5A","Orphan","Unknown"]
[null,"GPRC5B","Orphan","Unknown"]
[null,"GPRC5C","Orphan","Unknown"]
[null,"GPRC5D","Orphan","Unknown"]
[null,"GPRC6A","glycine","Gq/G11"]
[null,"GRM1","L-glutamic acid","Gq/G11"]
[null,"GRM2","L-glutamic acid","Gi/Go"]
[null,"GRM3","L-glutamic acid","Gi/Go"]
[null,"GRM4","L-glutamic acid","Gi/Go"]
[null,"GRM5","L-glutamic acid","Gq/G11"]
[null,"GRM6","L-glutamic acid","Gi/Go"]
[null,"GRM7","L-glutamic acid","Gi/Go"]
[null,"GRM8","L-glutamic acid","Gi/Go"]
[null,"GRPR","gastrin-releasing peptide","Gq/G11"]
[null,"HCAR1","hydroxycarboxylic acid","Gi/Go"]
[null,"HCAR2","hydroxycarboxylic acid","Gi/Go"]
[null,"HCAR3","hydroxycarboxylic acid","Gi/Go"]
[null,"HCRTR1","orexin-A","Gs, Gi/Go, Gq/G11"]
[null,"HCRTR2","orexin-A","Gs, Gi/Go, Gq/G11"]
[null,"HRH1","histamine","Gq/G11"]
[null,"HRH2","histamine","Gq/G11"]
[null,"HRH3","histamine","Gi/Go"]
[null,"HRH4","CCL16","Gi/Go"]
[null,"HTR1A","5-hydroxytryptamine","Gi/Go"]
[null,"HTR1B","5-hydroxytryptamine","Gi/Go"]
[null,"HTR1D","5-hydroxytryptamine","Gi/Go"]
[null,"HTR1E","5-hydroxytryptamine","Gi/Go"]
[null,"HTR1F","5-hydroxytryptamine","Gi/Go"]
[null,"HTR2A","5-hydroxytryptamine","Gq/G11"]
[null,"HTR2B","5-hydroxytryptamine","Gq/G11"]
[null,"HTR2C","5-hydroxytryptamine","Gq/G11"]
[null,"HTR4","5-hydroxytryptamine","Gs"]
[null,"HTR5A","5-hydroxytryptamine","Gi/Go"]
[null,"HTR6","5-hydroxytryptamine","Gs"]
[null,"HTR7","5-hydroxytryptamine","Gs"]
[null,"KISS1R","kisspeptin receptor","Gq/G11"]
[null,"LGR4","R-spondin-1","Unknown"]
[null,"LGR5","R-spondin-1","Unknown"]
[null,"LGR6","R-spondin-3","Unknown"]
[null,"LHCGR","hCG","Gs"]
[null,"LPAR1","lysophosphatidic acid","G12/G13, Gi/Go, Gq/G11"]
[null,"LPAR2","lysophosphatidic acid","G12/G13, Gi/Go, Gq/G11"]
[null,"LPAR3","lysophosphatidic acid","Gi/Go, Gq/G11"]
[null,"LPAR4","lysophosphatidic acid","Gs, G12/G13, Gi/Go, Gq/G11"]
[null,"LPAR5","lysophosphatidic acid","Gq/G11, G12/G13"]
[null,"LPAR6","lysophosphatidic acid","Gs, G12/G13, Gi/Go"]
[null,"LTB4R","12R-HETE","Gi/Go, Gq/G11"]
[null,"LTB4R2","12-hydroxyheptadecatrienoic acid","Gi/Go"]
[null,"MAS1","Orphan","Gi/Go, Gq/G11"]
[null,"MAS1L","Orphan","Unknown"]
[null,"MC1R","&alpha;-MSH","Gs"]
[null,"MC2R","ACTH","Gs"]
[null,"MC3R","&alpha;-MSH","Gs"]
[null,"MC4R","&alpha;-MSH","Gs"]
[null,"MC5R","&alpha;-MSH","Gs"]
[null,"MCHR1","melanin concentrating hormone receptor 1","Gi/Go, Gq/G11, Gs"]
[null,"MCHR2","melanin concentrating hormone receptor 2","Gq/G11"]
[null,"MLNR","motilin","Gq/G11, G12/G13"]
[null,"MRGPRD","&beta;-alanine","Gi/Go, Gq/G11"]
[null,"MRGPRE","Orphan","Unknown"]
[null,"MRGPRF","Orphan","Unknown"]
[null,"MRGPRG","Orphan","Unknown"]
[null,"MRGPRX1","bovine adrenal medulla peptide 8-22","Gq/G11"]
[null,"MRGPRX2","PAMP-20","Gi/Go, Gq/G11"]
[null,"MRGPRX3","Orphan","Gq/G11"]
[null,"MRGPRX4","Orphan","Gq/G11"]
[null,"MTNR1A","melatonin","Gi/Go"]
[null,"MTNR1B","melatonin","Gi/Go"]
[null,"NMBR","gastrin releasing peptide(14-27) (human)","Gq/G11"]
[null,"NMUR1","neuromedin S-33","Gq/G11"]
[null,"NMUR2","neuromedin S-33","Gq/G11"]
[null,"NPBWR1","NPBWR1","Gi/Go"]
[null,"NPBWR2","neuropeptides B/W receptor 2","Gi/Go"]
[null,"NPFFR1","neuropeptide FF receptor 1","Gi/Go"]
[null,"NPFFR2","neuropeptide FF receptor 2","Gi/Go"]
[null,"NPSR1","neuropeptide S receptor 2","Gq/G11"]
[null,"NPY1R","neuropeptide Y","Gi/Go"]
[null,"NPY2R","neuropeptide Y","Gi/Go"]
[null,"NPY4R","neuropeptide Y receptor Y5","Gi/Go"]
[null,"NPY5R","[Leu<sup>31</sup>,Pro<sup>34</sup>]PYY (human)","Gi/Go"]
[null,"NPY6R","Orphan","Unknown"]
[null,"NTSR1","large neuromedin N","Gq/G11"]
[null,"NTSR2","neurotensin","Gq/G11"]
[null,"OPN3","Orphan","Unknown"]
[null,"OPN4","Orphan","Gi/Go, Gq/G11"]
[null,"OPN5","Orphan","Gi/Go"]
[null,"OPRD1","&beta;-endorphin","Gi/Go"]
[null,"OPRK1","&alpha;-neoendorphin","Gi/Go"]
[null,"OPRL1","nociceptin/orphanin FQ","Gi/Go"]
[null,"OPRM1","dynorphin A","Gi/Go"]
[null,"OR51E1","Olfactory Receptor, unlcear why it is the only olfactory receptor annotated by IUPHAR","Unknown"]
[null,"OXER1","5-oxo-12-HETE","Gi/Go"]
[null,"OXGR1","&alpha;-ketoglutaric acid","Gq/G11"]
[null,"OXTR","arginine vasotocin","Gq/G11"]
[null,"P2RY1","ATP","Gq/G11"]
[null,"P2RY10","LPA","Unknown"]
[null,"P2RY11","ATP","Gq/G11"]
[null,"P2RY12","adenosine diphosphate","Gi/Go"]
[null,"P2RY13","adenosine diphosphate","Gi/Go"]
[null,"P2RY14","UDP-galactose","Gi/Go"]
[null,"P2RY2","ATP","Gq/G11"]
[null,"P2RY4","uridine triphosphate","Gq/G11"]
[null,"P2RY6","uridine diphosphate","Gq/G11"]
[null,"P2RY8","Orphan","Unknown"]
[null,"PRLHR","prolactin releasing hormone receptor","?"]
[null,"PROKR1","prokineticin receptor 2","Gq/G11"]
[null,"PROKR2","prokineticin receptor 2","Gq/G11"]
[null,"PTAFR","PAF","Gi/Go, Gq/G11"]
[null,"PTGDR","PGD<sub>2</sub>","Gs"]
[null,"PTGDR2","prostaglandin E receptor 2","Gi/Go"]
[null,"PTGER1","PGD<sub>2</sub>","Gq/G11"]
[null,"PTGER2","PGD<sub>2</sub>","Gs"]
[null,"PTGER3","PGE<sub>2</sub>","Gi/Go"]
[null,"PTGER4","PGD<sub>2</sub>","Gs"]
[null,"PTGFR","PGD<sub>2</sub>","Gq/G11"]
[null,"PTGIR","PGE<sub>1</sub>","Gs"]
[null,"PTH1R","parathyroid hormone 2 receptor","Gs"]
[null,"PTH2R","parathyroid hormone 2 receptor","Gs"]
[null,"QRFPR","pyroglutamylated RFamide peptide receptor","Gi/Go, Gq/G11"]
[null,"RXFP1","relaxin/insulin like family peptide receptor 1","Gs, Gi/Go"]
[null,"RXFP2","relaxin/insulin like family peptide receptor 2","Gs, Gi/Go"]
[null,"RXFP3","relaxin/insulin like family peptide receptor 3","Gi/Go"]
[null,"RXFP4","relaxin/insulin like family peptide receptor 4","Gi/Go"]
[null,"S1PR1","sphingosine-1-phosphate","Gi/Go"]
[null,"S1PR2","sphingosine-1-phosphate","Gs, Gi/Go, Gq/G11"]
[null,"S1PR3","sphingosine-1-phosphate","G12/G13, Gi/Go, Gq/G11"]
[null,"S1PR4","sphingosine-1-phosphate","Gi/Go, G12/G13"]
[null,"S1PR5","sphingosine-1-phosphate","Gi/Go, G12/G13"]
[null,"SCTR","secretin","Gs"]
[null,"SMO","Orphan","Gi/Go, G12/G13"]
[null,"SSTR1","cortistatin-14","Gi/Go"]
[null,"SSTR2","cortistatin-14","Gi/Go"]
[null,"SSTR3","cortistatin-14","Gi/Go"]
[null,"SSTR4","cortistatin-14","Gi/Go"]
[null,"SSTR5","cortistatin-14","Gi/Go"]
[null,"SUCNR1","succinic acid","Gi/Go, Gq/G11"]
[null,"TAAR1","&beta;-phenylethylamine","Gs"]
[null,"TAAR2","Orphan","Unknown"]
[null,"TAAR3","Orphan","Unknown"]
[null,"TAAR5","Orphan","Unknown"]
[null,"TAAR6","Orphan","Unknown"]
[null,"TAAR8","Orphan","Unknown"]
[null,"TAAR9","Orphan","Unknown"]
[null,"TACR1","hemokinin 1","Gs, Gq/G11"]
[null,"TACR2","hemokinin 1","Gs, Gq/G11"]
[null,"TACR3","neurokinin A","Gq/G11"]
[null,"TAS1R1","Orphan","Unknown"]
[null,"TAS1R2","Orphan","Unknown"]
[null,"TAS1R3","Orphan","Unknown"]
[null,"TAS2R1","Orphan","Unknown"]
[null,"TAS2R10","Orphan","Unknown"]
[null,"TAS2R13","Orphan","Unknown"]
[null,"TAS2R14","Orphan","Unknown"]
[null,"TAS2R16","Orphan","Unknown"]
[null,"TAS2R19","Orphan","Unknown"]
[null,"TAS2R20","Orphan","Unknown"]
[null,"TAS2R3","Orphan","Unknown"]
[null,"TAS2R30","Orphan","Unknown"]
[null,"TAS2R31","Orphan","Unknown"]
[null,"TAS2R38","Orphan","Unknown"]
[null,"TAS2R39","Orphan","Unknown"]
[null,"TAS2R4","Orphan","Unknown"]
[null,"TAS2R40","Orphan","Unknown"]
[null,"TAS2R41","Orphan","Unknown"]
[null,"TAS2R42","Orphan","Unknown"]
[null,"TAS2R43","Orphan","Unknown"]
[null,"TAS2R46","Orphan","Unknown"]
[null,"TAS2R5","Orphan","Unknown"]
[null,"TAS2R50","Orphan","Unknown"]
[null,"TAS2R60","Orphan","Unknown"]
[null,"TAS2R7","Orphan","Unknown"]
[null,"TAS2R8","Orphan","Unknown"]
[null,"TAS2R9","Orphan","Unknown"]
[null,"TBXA2R","PGE<sub>2</sub>","Gq/G11"]
[null,"TPRA1","Orphan","Unknown"]
[null,"TRHR","TRH","Gq/G11"]
[null,"TSHR","TSH","Gs"]
[null,"UTS2R","urotensin-II","Gq/G11"]
[null,"VIPR1","GHRH","Gs"]
[null,"VIPR2","PACAP-27","Gs"]
[null,"XCR1","xcl1","Gi/Go"]

{"sheet":"Non-silent Mutations","index":3,"n_rows":394,"n_cols":26,"rows_kept":394,"flags":["formulas_cached_only"]}
["The number of tumors within each cancer type that possess a somatic non-silent GPCR mutation",null,null,"n = ",91,396,771,40,217,184,66,213,113,202,543,178,472,142,185,499,91,139,504,57,null,"Total number of samples = 5103"]
[null,"Gene Symbol DB","Number of Tumors with a mutation for the indicated GPCR",null,"Adrenocortical Cancer, ACC","Bladder Cancer, BLCA","Breast Cancer, BRCA","Cervical Cancer, CESC","Colon cancer, COAD","Esophageal cancer, ESCA","Kidney Chromophobe, KICH","Kidney Clear Cell Carcinoma, KIRC","Kidney Papillary Cell Carcinoma, KIRP","Liver hepatocellular carcinoma, LIHC","Lung adenocarcinoma, LUAD","Lung squamus cell carcinoma, LSQC","Skin cutaneous melanoma, SKCM","Ovarian carcinoma, OV","Pancreatic adenocarcinoma, PAAD","Prostate adenocarcinoma, PRAD","Stomach adenocarcinoma, STAD","Testicular carcinoma, TGCT","Thyroid carcinoma, THCA","Uterine carcinomasarcoma, UCS"]
["Number of replicates (n) for each tumor type are indicated above the cancer name","GPR98",432,null,6,42,15,4,31,15,0,6,4,22,56,31,177,2,2,11,2,1,4,1]
[null,"GPR112",286,null,0,23,8,3,9,4,0,6,0,8,90,15,98,2,5,7,5,0,1,2]
["Gene names are based on Hg19, which was used for TCGA mutation analysis; sheet 2 shows IUPHAR gene names","BAI3",254.5,null,2,15,7,0,12.5,11,0,2,2,8,63,22,87,1,1,10,6,1,3,1]
[null,"LPHN3",205,null,2,20,7,0,15.5,7,1,0.5,0,8,68,16,45,0,0,9,3,1,1,1]
["Mutational status (1 or 0 for mutated or not) for each GPCR in each TCGA sample in each cancer type is downloadable at     insellab.github.io","GPR158",190,null,2,20,2,1,14,5,1,2,0,8,52,15,53,0,3,7,2,0,1,2]
[null,"LPHN2",188,null,1,21,6,0,10.5,9,0,0.5,2,6,42,7,66,0,4,4,4,2,1,2]
["Values with 0.5 occur in cases for which two aliquots of the same sample were tested, with only one sample positive for a mutation","GRM8",185.5,null,1,7,3,1,8.5,10,1,3,0,9,47,14,69,0,4,2,3,2,0,1]
[null,"GRM7",174,null,0,12,3,0,14,3,1,2,0,7,40,10,67,2,1,3,6,0,0,3]
[null,"GRM3",166.5,null,4,10,8,0,5,10,2,3,0,8,16.5,13,77,0,1,3,5,0,0,1]
[null,"CELSR1",159,null,1,19,6,0,21,6,2,6,4,13,15,9,40,0,3,4,3,3,3,1]
[null,"CELSR2",157.5,null,11,15,7,6,21.5,5,1,6,1,9,19,8,28,3,2,5,6,0,1,3]
[null,"GRM1",156.5,null,1,19,4,0,12.5,8,0,3,0,8,40,12,22,1,4,10,9,1,1,1]
[null,"CELSR3",154.5,null,0,25,7,1,11.5,3,2,2.5,1,10,29.5,8,35,0,5,6,4,0,1,3]
[null,"CASR",152.5,null,1,5,8,1,14.5,1,0,0,0,8,20,11,74,1,2,3,2,0,0,1]
[null,"ELTD1",143.5,null,1,10,4,0,5.5,2,0,0,1,11,35,18,48,0,5,1,1,0,1,0]
[null,"GRM5",143,null,1,17,2,0,15,4,0,4,1,8,41,12,25,1,1,4,6,0,0,1]
[null,"GPR179",140.5,null,0,18,5,1,13,1,1,2.5,1,8,17,3,52,2,1,3,9,1,1,1]
[null,"CHRM2",122.5,null,0,5,4,0,7.5,7,1,2,1,8,33,10,37,0,1,2,2,0,0,2]
[null,"FSHR",115.5,null,0,5,4,0,4,4,0,0.5,0,5,30,15,36,2,2,2,4,0,1,1]
[null,"BAI1",114.5,null,0,5,8,3,7.5,6,2,1,2,9,21,10,22,1,3,7,5,0,1,1]
[null,"GRM6",110,null,0,8,3,0,10,3,0,1,0,6,17,6,41,1,2,2,4,0,4,2]
[null,"CHRM3",108,null,0,8,1,0,5,4,0,1,0,8,26,5,41,1,1,1,3,1,1,1]
[null,"HCRTR2",106.5,null,0,9,3,0,1,5,0,4,1,4,23.5,3,44,0,1,4,1,0,0,3]
[null,"LHCGR",106,null,0,7,5,0,8,4,0,0,0,8,13,8,42,1,2,1,3,1,0,3]
[null,"GPR116",103,null,0,9,3,1,6,2,0,1,1,8,9,5,50,0,1,2,3,0,1,1]
[null,"TAS1R2",99.5,null,0,6,1,0,9.5,2,1,0,3,6,27,0,34,0,1,4,4,0,1,0]
[null,"EMR1",96,null,1,4,2,0,5,5,0,0,0,5,22,10,39,0,0,0,1,0,0,2]
[null,"CALCR",95,null,1,9,1,0,4,0,0,0,1,3,24,11,31,2,1,4,1,0,1,1]
[null,"LGR5",94,null,1,11,3,0,8,2,0,1,0,5,26,4,26,0,1,2,0,0,1,3]
[null,"BAI2",93.5,null,2,7,3,0,12.5,7,1,1.5,1,8,14.5,7,18,1,3,2,1,2,1,1]
[null,"GPR133",93,null,1,12,2,0,8,2,1,2,1,7,16,3,28,0,3,2,3,0,1,1]
[null,"LGR6",93,null,0,7,3,1,5,4,0,1,0,5,21,1,38,1,1,2,1,0,0,2]
[null,"GPRC6A",92,null,0,7,2,1,5,2,0,0,0,8,0,2,58,1,2,0,4,0,0,0]
[null,"FZD10",89.5,null,0,10,0,0,6,1,0,4,1,6,30.5,2,15,0,6,5,1,1,1,0]
[null,"GRM4",87.5,null,1,8,1,2,5.5,6,0,1,1,6,15,3,28,0,2,2,0,1,2,3]
[null,"GPR115",84,null,0,4,1,0,7,3,0,1,0,5,17,5,32,2,1,3,1,1,1,0]
[null,"TACR3",84,null,1,5,1,0,4,0,0,2,0,4,14,4,40,1,2,2,1,0,3,0]
[null,"RXFP1",84,null,1,8,3,0,3,4,0,1,0,3,19,8,28,0,1,2,0,0,1,2]
[null,"GPR50",84,null,2,13,2,0,9,1,0,0,0,2,18,4,27,1,1,3,1,0,0,0]
[null,"MCHR2",82,null,0,2,2,1,10,2,0,3,0,3,15,6,31,1,2,2,1,0,0,1]
[null,"DRD5",81.5,null,0,3,2,1,6,1,0,2.5,2,2,21,4,30,0,1,2,2,0,2,0]
[null,"NPSR1",78,null,0,4,1,0,3,0,0,1,0,5,15,3,43,0,0,0,1,0,1,1]
[null,"HTR2C",78,null,1,1,2,0,7,1,0,1,0,6,10,5,33,3,2,3,3,0,0,0]
[null,"HTR5A",77.5,null,2,3,2,0,10.5,1,0,0,0,2,18,4,26,0,3,1,3,1,0,1]
[null,"HTR1E",76,null,0,1,3,0,8.5,4,0,1.5,0,1,22,5,19,2,0,6,2,0,0,1]
[null,"CCKBR",76,null,0,8,1,0,7,2,0,0,2,6,23,2,17,0,1,2,5,0,0,0]
[null,"ADCYAP1R1",76,null,1,6,1,0,1,1,0,1,1,5,15,8,33,0,0,2,0,0,1,0]
[null,"TSHR",75.5,null,0,7,4,1,6.5,2,0,1,0,3,20,5,19,0,1,1,3,0,1,1]
[null,"HTR1A",75,null,0,9,3,1,8,1,0,2,0,2,19,7,15,1,2,3,2,0,0,0]
[null,"NPFFR2",74.5,null,1,5,4,0,5.5,2,0,1,0,3,21,8,19,1,1,0,2,0,1,0]
[null,"GPR139",74,null,0,0,2,0,6,3,1,0,0,3,22,2,29,0,1,1,2,0,2,0]
[null,"GPR125",73.5,null,1,9,4,0,6.5,1,0,0,1,4,22,6,10,0,3,4,1,0,0,1]
[null,"EMR3",73,null,1,4,3,0,5.5,2,0,3.5,0,8,9,5,27,2,1,1,1,0,0,0]
[null,"OPRM1",73,null,0,0,7,0,11.5,4,0,2.5,0,9,15,6,13,0,1,2,2,0,0,0]
[null,"RXFP2",72,null,0,5,1,1,7,3,0,0,0,5,8,3,33,0,1,1,1,0,2,1]
[null,"NPY5R",72,null,0,5,0,0,1,0,0,0,0,7,18,4,33,0,1,2,0,0,0,1]
[null,"GRM2",72,null,0,10,3,0,10.5,2,0,1,2.5,7,7,3,21,0,1,1,2,0,1,0]
[null,"LPHN1",71.5,null,2,9,3,1,14.5,1,1,0,1,8,7,3,11,0,2,3,2,2,0,1]
[null,"NMUR2",71.5,null,0,1,2,0,8.5,0,0,0,0,5,20,2,29,0,1,2,1,0,0,0]
[null,"GPR156",71,null,1,8,3,1,6,2,0,0,0,3,16,4,19,1,2,2,3,0,0,0]
[null,"PTH2R",70.5,null,0,7,2,0,4.5,2,0,0,0,4,14,6,26,1,0,0,3,0,1,0]
[null,"NPY2R",70.5,null,0,3,1,0,5.5,2,0,4,1,3,19,4,23,0,1,2,2,0,0,0]
[null,"MRGPRX1",70.5,null,0,8,1,1,5.5,2,0,0,0,4,7,6,30,0,1,4,1,0,0,0]
[null,"GPR123",70,null,0,6,0,0,4.5,3,0,2,1,2,12.5,4,28,0,2,2,0,0,2,1]
[null,"GPR149",70,null,0,6,3,0,9,2,0,2,0,7,0,5,26,2,1,1,3,0,1,2]
[null,"CALCRL",70,null,0,8,2,0,1,1,0,0,1,1,18,3,30,1,0,1,2,0,0,1]
[null,"GABBR2",69.5,null,0,6,2,0,9.5,3,0,0,0,3,13,3,20,1,2,3,3,0,0,1]
[null,"NPY1R",69,null,0,6,4,1,1,0,1,0,0,3,15,3,30,0,2,2,1,0,0,0]
[null,"GPR126",68.5,null,2,8,3,1,5,0,0,2.5,0,5,15,6,14,0,1,3,3,0,0,0]
[null,"GPR110",68.5,null,0,8,3,0,5.5,2,0,1,1,7,3,3,27,2,1,2,2,0,0,1]
[null,"GABBR1",68,null,1,7,1,1,10,2,0,1.5,0,8,8.5,5,14,1,2,1,4,0,0,1]
[null,"PTGER3",67,null,0,4,3,1,8.5,1,0,2,0,5,12.5,4,22,0,0,0,2,1,1,0]
[null,"EDNRB",66,null,1,8,2,0,6,3,0,2,0,6,17,5,10,0,1,0,4,0,0,1]
[null,"PROKR2",65,null,0,5,0,0,3,1,0,0,0,2,14,4,25,1,0,4,4,0,1,1]
[null,"GLP2R",65,null,0,3,1,0,3,2,0,0,0,6,17,5,22,0,1,1,1,0,2,1]
[null,"GPR128",64,null,0,3,2,0,4,0,0,1,1,5,19,7,18,0,2,1,0,0,0,1]
[null,"DRD2",64,null,0,3,2,0,2,2,0,1,0,1,21,4,25,0,0,1,1,0,0,1]
[null,"GPR174",63,null,0,4,3,0,2,2,0,2,1,6,18,5,18,0,1,1,0,0,0,0]
[null,"SMO",62.5,null,2,8,2,0,4.5,2,1,2,0,4,16,1,14,0,2,0,3,0,0,1]
[null,"PTGFR",62,null,0,7,1,0,1,0,0,1,0,5,11,5,27,2,1,0,1,0,0,0]
[null,"TAS2R60",61,null,0,4,0,0,1,3,0,1,0,2,9,7,33,0,1,0,0,0,0,0]
[null,"EMR2",60,null,1,6,5,0,6,2,0,0,0,5,12,3,10,0,1,6,2,0,1,0]
[null,"CMKLR1",60,null,0,3,2,1,3,2,0,0,0,3,19,2,21,0,1,2,0,0,0,1]
[null,"ADRA1A",60,null,0,6,2,1,5,4,0,1,1,2,7,2,21,0,3,1,3,0,1,0]
[null,"GPR124",59.5,null,1,5,0,0,4,3,1,1,1,7,9.5,4,11,0,4,3,2,1,1,1]
[null,"LGR4",59.5,null,0,6,3,0,8,0,0,1,2,5,9.5,3,16,1,1,1,2,0,0,1]
[null,"TRHR",59,null,0,8,0,0,1,0,0,1,0,4,0,2,37,0,1,1,2,0,0,2]
[null,"GPR111",58.5,null,0,2,2,0,2.5,0,0,1,0,4,14,6,26,0,0,0,1,0,0,0]
[null,"DARC",58.5,null,0,2,2,1,3.5,3,0,0,0,3,16,7,17,0,0,1,3,0,0,0]
[null,"GPR64",58,null,0,7,6,1,10,0,0,0,0,5,12,4,9,0,1,1,1,0,0,1]
[null,"OPRK1",58,null,0,4,2,0,2,1,1,0,0,2,11,1,30,0,1,1,2,0,0,0]
[null,"HTR7",57.5,null,0,4,0,0,9,1,0,1.5,0,8,12,3,16,0,1,0,2,0,0,0]
[null,"RXFP3",57,null,0,4,3,0,8,2,1,1,0,4,15,9,7,0,1,1,0,0,0,1]
[null,"FPR2",57,null,1,5,1,0,4,3,0,1,1,2,12,2,20,0,0,1,3,0,0,1]
[null,"FPR1",57,null,1,3,1,0,4,2,0,0,0,2,9,1,26,0,2,3,2,0,1,0]
[null,"CCKAR",57,null,0,3,1,0,4,1,1,2,1,3,14,2,18,0,2,2,2,0,0,1]
[null,"CX3CR1",56,null,1,4,3,0,3,2,0,1,0,3,10,3,24,0,0,0,1,0,0,1]
[null,"GPR97",55,null,0,7,3,1,6.5,1,0,0.5,1,3,8,3,18,0,0,1,1,0,0,1]
[null,"HTR1F",55,null,0,6,2,1,3,4,1,0,0,6,10,3,15,1,1,0,2,0,0,0]
[null,"CD97",54.5,null,1,5,5,1,6,1,0,0.5,1,4,11,0,10,2,1,2,3,1,0,0]
[null,"TAS2R16",54,null,0,4,3,1,5,1,0,0,0,4,15,4,15,1,1,0,0,0,0,0]
[null,"TAS2R1",54,null,1,1,1,1,2,0,0,0,0,4,20,4,17,1,2,0,0,0,0,0]
[null,"LPAR4",54,null,0,2,1,0,3,0,0,1,0,2,16,6,20,0,1,0,1,0,0,1]
[null,"GPR101",54,null,0,7,5,0,2.5,1,1,0,0,4,18.5,1,9,0,0,1,1,0,3,0]
[null,"GPR37",53.5,null,0,5,2,0,2.5,2,0,1,1,3,17,2,8,1,0,1,4,1,0,3]
[null,"TAS2R41",53,null,0,3,0,0,1,1,0,0,1,4,15,5,22,0,1,0,0,0,0,0]
[null,"OR51E1",52.5,null,1,4,1,1,7,1,0,1,0,4,8.5,1,20,0,2,0,0,1,0,0]
[null,"P2RY10",52,null,0,2,2,0,2,3,0,0,0,1,20,5,12,0,0,1,1,0,0,3]
[null,"OPRL1",51.5,null,1,2,2,1,2,4,0,1.5,0,4,12,2,13,0,2,2,1,0,1,1]
[null,"MTNR1B",50.5,null,0,1,0,0,6.5,2,0,1,0,2,11,10,10,0,2,2,2,0,1,0]
[null,"CNR1",50.5,null,0,4,2,1,6.5,4,0,0,0,2,0,5,18,0,0,4,0,0,2,2]
[null,"TAAR6",50,null,0,3,2,0,3,0,0,0,0,2,15,5,14,1,1,3,1,0,0,0]
[null,"MC5R",50,null,0,3,0,1,1,0,0,1,0,5,18,3,12,1,2,1,2,0,0,0]
[null,"MC3R",50,null,0,4,1,0,4,0,0,1,0,3,15,2,12,1,2,1,2,0,0,2]
[null,"HTR4",50,null,0,6,0,0,1,1,0,0,0,4,8,3,22,1,1,1,0,0,1,1]
[null,"GPRC5C",50,null,0,3,0,0,6,2,0,1,0,4,8,4,16,0,1,1,4,0,0,0]
[null,"GPR83",49.5,null,1,3,4,0,2.5,4,0,0,0,2,12,2,15,0,1,2,1,0,0,0]
[null,"TAS2R38",49,null,0,0,1,0,4,0,0,1,0,0,9,2,28,0,2,2,0,0,0,0]
[null,"OPRD1",49,null,0,5,2,0,22,0,1,1,0,0,2,2,8,0,2,1,2,0,0,1]
[null,"DRD1",49,null,0,2,0,1,7,3,0,0,0,4,12,1,15,0,3,0,1,0,0,0]
[null,"AGTR1",48.5,null,0,3,0,0,6.5,0,0,0,0,6,9,5,16,0,0,3,0,0,0,0]
[null,"TAS1R3",48,null,0,12,1,0,7,1,1,1,0,6,5,2,6,0,1,1,1,1,1,1]
[null,"S1PR1",48,null,0,8,0,0,4,1,0,0,0,0,12,3,13,2,2,1,0,0,1,1]
[null,"GPR142",48,null,0,7,3,0,4,2,0,1,0,6,0,3,15,1,1,1,2,0,1,1]
[null,"F2R",48,null,0,2,3,1,6,2,1,0,0,4,9,2,12,0,0,2,4,0,0,0]
[null,"ADORA3",48,null,0,5,2,0,5,1,0,0,0,6,4,1,16,0,3,3,2,0,0,0]
[null,"SSTR4",47.5,null,0,5,0,0,8.5,0,0,1,1,3,14,2,8,0,1,2,1,0,0,1]
[null,"C3AR1",47.5,null,1,4,2,0,2.5,2,0,1,2,2,10,2,13,0,1,2,2,0,0,1]
[null,"GPR141",47,null,0,9,0,0,2,2,0,0,0,3,0,4,18,3,0,3,2,0,1,0]
[null,"CCR2",47,null,0,0,5,0,2,1,1,0,1,3,6,1,26,0,0,1,0,0,0,0]
[null,"TAS1R1",46.5,null,0,2,1,0,5,0,1,0,1,6,5.5,3,19,0,1,0,1,1,0,0]
[null,"SSTR1",46.5,null,1,3,0,1,5,1,0,0.5,0,1,9,3,16,1,1,3,1,0,0,0]
[null,"HRH1",46.5,null,0,9,2,0,2,1,0,0,0,2,4.5,3,22,0,0,1,0,0,0,0]
[null,"GPR45",46.5,null,0,4,1,0,3,1,0,2,0,2,12.5,4,10,0,0,1,4,1,0,1]
[null,"APLNR",46.5,null,1,4,3,0,2.5,2,0,0,1,3,7,7,14,0,0,1,0,0,0,1]
[null,"AVPR1A",46,null,2,4,0,0,9,3,0,1,0,1,11,3,6,0,1,2,3,0,0,0]
[null,"GPR113",45.5,null,0,3,1,0,7.5,1,0,0,2,6,2,0,14,1,3,1,2,0,2,0]
[null,"SSTR3",45.5,null,1,4,2,0,4,3,0,1,0,2,7.5,2,14,0,1,2,2,0,0,0]
[null,"DRD3",45.5,null,0,1,1,0,1.5,2,1,0,0,4,16,5,10,0,0,2,1,0,0,1]
[null,"CRHR1",45.5,null,0,4,1,0,3,2,0,1,0,7,7.5,4,12,0,0,0,1,0,2,1]
[null,"PTH1R",45,null,0,7,1,1,2,2,0,0,2,5,5,1,15,0,0,1,3,0,0,0]
[null,"GPR63",45,null,0,3,1,0,1,0,0,1,0,7,9,4,15,0,0,1,1,0,0,2]
[null,"GPR32",45,null,0,1,2,0,3.5,5,0,1,0,1,15.5,1,11,0,0,2,1,0,0,1]
[null,"P2RY8",44.5,null,0,1,2,0,7,2,0,0,0,3,8.5,2,14,0,2,1,2,0,0,0]
[null,"OPN4",44.5,null,1,1,4,0,3.5,2,0,1,0,5,11,1,12,1,0,0,0,0,2,0]
[null,"MTNR1A",44,null,1,4,0,0,0,1,0,0,0,2,15,1,16,0,1,1,0,0,1,1]
[null,"HTR2A",44,null,1,2,3,0,4,1,0,0,0,3,6,3,15,0,2,2,2,0,0,0]
[null,"GPR161",44,null,0,8,2,0,4,4,1,0,0,7,6,2,8,0,1,0,1,0,0,0]
[null,"AGTR2",44,null,1,4,0,0,2,2,0,0,1,2,5,3,23,0,1,0,0,0,0,0]
[null,"PROKR1",43.5,null,1,1,1,0,6.5,1,0,2,0,1,11,2,12,0,2,2,1,0,0,0]
[null,"LPAR1",43,null,0,3,2,1,3,2,0,0,0,1,3,1,25,0,1,1,0,0,0,0]
[null,"GPR85",42.5,null,1,4,1,1,2.5,2,0,1,0,4,16,2,6,0,0,0,1,0,0,1]
[null,"GPR20",42.5,null,2,2,1,0,10.5,2,0,0,0,2,4,2,15,0,0,1,0,0,0,1]
[null,"GHRHR",42.5,null,0,5,2,0,0,1,0,0,0,3,6.5,4,18,1,1,1,0,0,0,0]
[null,"FPR3",42.5,null,0,3,1,0,1.5,1,0,0,0,4,2,3,21,0,1,1,2,0,0,2]
[null,"PRLHR",42,null,1,4,0,0,10,3,0,0,0,3,9,2,9,0,0,0,1,0,0,0]
[null,"OPN5",42,null,1,3,0,0,1,2,0,0,0,4,14,3,11,0,0,2,0,0,0,1]
[null,"GPR162",42,null,1,7,3,0,6,0,0,1,1,3,4,2,10,1,0,2,0,1,0,0]
[null,"FZD7",42,null,0,7,1,1,6,3,0,0,0,4,6,3,5,1,0,2,3,0,0,0]
[null,"PTGDR",41.5,null,0,3,1,0,1.5,0,0,0,1,3,8,6,16,0,1,0,1,0,0,0]
[null,"NPY4R",41,null,0,5,0,0,0,1,0,0,0,3,6,0,20,0,1,2,1,0,0,2]
[null,"MRGPRX2",41,null,0,3,0,0,6,1,0,0,0,4,4,1,15,0,0,4,2,0,1,0]
[null,"HRH4",41,null,0,3,1,0,2,2,0,1,0,5,5,4,13,0,0,2,3,0,0,0]
[null,"GPR78",41,null,1,1,1,0,12,1,0,2,0,1,7,2,9,0,0,1,2,0,1,0]
[null,"GLP1R",41,null,0,3,0,1,3,1,1,0,0,5,8,1,17,0,0,1,0,0,0,0]
[null,"CXCR2",41,null,0,0,0,0,2,4,0,0,0,2,8,1,22,0,0,2,0,0,0,0]
[null,"QRFPR",40,null,1,2,0,0,6,2,0,0,0,6,7,6,6,0,0,0,3,0,0,1]
[null,"AVPR1B",40,null,0,3,2,1,3,0,0,0,0,5,7,2,14,0,0,2,0,1,0,0]
[null,"MRGPRX3",39.5,null,0,2,2,0,4.5,2,1,1,1,2,8,1,4,1,1,2,6,0,0,1]
[null,"FZD6",39.5,null,0,11,3,0,5.5,3,0,0,0,5,2,2,3,0,1,3,1,0,0,0]
[null,"FZD1",39.5,null,6,4,1,1,7,3,0,1.5,1,1,5,1,5,0,1,1,1,0,0,0]
[null,"TACR1",39,null,0,3,1,0,3,0,0,1,0,7,5,3,11,1,1,2,0,0,0,1]
[null,"SCTR",39,null,0,4,0,0,3,1,0,0,0,4,4,1,15,1,0,3,3,0,0,0]
[null,"NTSR2",39,null,0,2,1,0,19,0,0,0,0,1,6,3,3,0,0,2,1,0,1,0]
[null,"MRGPRX4",39,null,1,0,1,0,1,0,0,1,0,4,12,4,8,0,0,3,2,0,2,0]
[null,"GHSR",39,null,0,8,1,0,3,1,0,0,0,4,5,4,12,0,0,1,0,0,0,0]
[null,"FZD2",39,null,0,3,1,0,3.5,3,0,2.5,0,4,8,1,8,0,1,1,2,0,0,1]
[null,"CCR1",39,null,0,1,1,0,2,1,0,0,0,7,3,3,15,0,1,3,2,0,0,0]
[null,"TAAR2",38.5,null,0,0,1,0,1.5,0,1,0,0,5,8,4,13,0,1,1,3,0,0,0]
[null,"OXGR1",38.5,null,0,2,3,0,1.5,1,0,0,0,4,9,2,15,1,0,0,0,0,0,0]
[null,"CCR3",38.5,null,1,2,1,0,2.5,1,0,0,1,5,3,1,15,1,0,0,3,0,0,2]
[null,"GPR114",38,null,0,5,2,0,3,0,0,1,0,6,6,2,10,0,1,0,0,1,1,0]
[null,"LPAR3",38,null,0,6,0,0,2,0,0,0,0,4,6,3,13,1,0,2,0,0,0,1]
[null,"HRH2",38,null,0,1,2,1,7,1,0,0,0,4,14,2,4,0,0,1,0,0,1,0]
[null,"GPR65",38,null,0,3,0,0,1,0,1,1.5,0,2,12.5,3,14,0,0,0,0,0,0,0]
[null,"GPR39",38,null,1,4,0,0,2,1,0,0,0,3,6,2,14,0,2,1,0,1,0,1]
[null,"EDNRA",38,null,0,4,1,0,2,1,0,0,0,4,2,1,20,0,0,2,1,0,0,0]
[null,"CCR5",38,null,0,5,1,0,6,0,0,0,2,1,4,2,14,0,0,2,1,0,0,0]
[null,"NMBR",37.5,null,0,6,2,0,2,0,0,0,0,2,7.5,3,14,0,0,1,0,0,0,0]
[null,"GPR61",37.5,null,0,4,1,1,3.5,0,0,1,0,4,8,2,11,0,1,0,0,0,0,1]
[null,"GPR37L1",37.5,null,0,5,0,0,4.5,2,0,0,0,3,0,2,10,1,7,2,1,0,0,0]
[null,"GPR15",37.5,null,0,2,0,1,5.5,2,0,1,0,4,9,4,5,1,1,1,0,0,0,1]
[null,"VIPR2",37,null,0,5,1,0,5,0,0,0,1,5,3,3,12,0,1,0,1,0,0,0]
[null,"TAAR5",37,null,0,2,3,0,3,2,0,0,0,2,10,5,7,0,1,1,0,0,1,0]
[null,"HTR6",37,null,1,5,0,0,4,1,0,0,0,5,10,2,7,1,0,1,0,0,0,0]
[null,"NTSR1",36.5,null,0,2,0,0,4,1,0,1,0,1,8.5,4,11,0,0,2,1,0,0,1]
[null,"BRS3",36,null,0,3,3,2,1.5,1,1,1,0,3,7.5,0,10,0,0,1,0,1,0,1]
[null,"TAS2R9",35.5,null,0,6,2,0,0,0,0,0.5,0,4,3,3,14,0,1,0,1,0,0,1]
[null,"PTGER4",35.5,null,1,5,0,0,4.5,3,0,1,0,4,7,2,3,0,0,1,3,0,1,0]
[null,"ADORA1",35.5,null,0,4,2,0,4.5,2,0,0,0,2,9,3,6,0,0,3,0,0,0,0]
[null,"TAAR9",35,null,0,3,0,0,0,2,0,0,0,4,12,3,6,0,1,2,0,1,0,1]
[null,"S1PR4",35,null,1,4,2,0,8,0,1,2,0,2,3,1,7,0,1,2,1,0,0,0]
[null,"NPBWR2",35,null,0,4,0,0,1,3,0,1,0,1,8,3,12,0,0,0,1,0,1,0]
[null,"MC2R",35,null,0,0,2,0,1,1,0,0,0,5,12,2,7,2,1,0,1,0,0,1]
[null,"HCAR3",35,null,0,2,1,0,5.5,2,0,0,0,3,4.5,3,11,1,0,0,1,0,1,0]
[null,"GPRC5B",35,null,0,1,0,0,1,3,0,1,0,2,13,0,6,0,2,1,4,0,1,0]
[null,"GPR152",35,null,0,2,0,0,6,0,0,1,0,5,7,1,12,0,1,0,0,0,0,0]
[null,"CXCR1",35,null,0,0,2,0,3,0,0,0,1,1,5,1,15,0,3,2,1,0,1,0]
[null,"BDKRB2",35,null,0,3,1,0,2,0,0,1,0,3,3,3,15,1,0,2,1,0,0,0]
[null,"GRPR",34.5,null,0,1,1,0,2,1,0,0.5,1,2,7,3,11,1,1,1,1,0,0,1]
[null,"GPR56",34,null,0,7,1,0,4,2,1,0,0,3,5,1,5,0,1,1,3,0,0,0]
[null,"HTR1D",34,null,0,6,0,0,2,4,0,1,0,1,5,0,11,0,1,2,0,1,0,0]
[null,"GPR87",34,null,0,2,0,0,3,2,1,0,0,3,4,4,9,0,1,3,0,1,1,0]
[null,"GPR75",34,null,1,8,2,0,4,1,0,1,0,3,5,2,6,0,0,1,0,0,0,0]
[null,"GPR26",34,null,0,0,1,0,6,3,0,0,0,1,11,2,5,0,3,1,1,0,0,0]
[null,"F2RL2",34,null,0,2,1,0,2,0,0,0,1,3,11,1,11,0,1,0,1,0,0,0]
[null,"CYSLTR1",34,null,0,0,2,1,3,1,0,1,0,4,5,2,11,1,0,2,0,0,0,1]
[null,"ADRA1D",34,null,0,5,0,0,4,2,0,0,0,5,8,3,5,0,0,2,0,0,0,0]
[null,"HRH3",33.5,null,0,4,2,0,1.5,1,1,0,1,5,7,1,7,0,1,0,1,1,0,0]
[null,"XCR1",33,null,0,0,4,0,4,1,0,1,0,3,6,2,7,0,2,2,1,0,0,0]
[null,"GPR84",33,null,1,2,3,0,2.5,2,0,1.5,0,3,4,0,12,0,0,1,1,0,0,0]
[null,"GALR1",33,null,0,3,2,0,4,0,0,0,0,2,7,5,6,0,2,0,1,0,0,1]
[null,"FZD3",33,null,0,6,3,0,3,1,0,1,0,4,2,5,2,0,2,0,2,0,1,1]
[null,"C5AR1",33,null,0,1,1,1,0,2,0,1,0,1,6,3,15,0,1,0,1,0,0,0]
[null,"GPR4",32.5,null,0,4,0,0,2.5,1,0,1,0,3,7,0,8,1,1,1,2,0,1,0]
[null,"GPR176",32.5,null,0,3,0,1,0.5,0,0,0,0,4,6,1,15,1,0,0,1,0,0,0]
[null,"BDKRB1",32.5,null,0,3,2,0,1.5,1,0,1,0,2,1,3,10,2,1,3,1,0,0,1]
[null,"P2RY1",32,null,0,3,3,0,2,0,0,0,1,8,4,3,7,0,1,0,0,0,0,0]
[null,"HTR1B",32,null,0,4,1,1,7,0,0,0,0,1,7,3,7,0,0,0,0,0,0,1]
[null,"GPR6",32,null,1,5,2,0,3,0,0,0,0,1,7,2,7,0,1,1,2,0,0,0]
[null,"GPR137",32,null,2,2,1,1,4,0,0,1,0,2,2,1,14,0,1,0,0,0,0,1]
[null,"FZD8",32,null,1,4,2,0,3,0,0,0,0,2,6,1,8,0,0,0,2,1,2,0]
[null,"CNR2",32,null,0,5,1,0,1,0,0,3,0,3,0,2,12,0,0,1,1,0,2,1]
[null,"ADRA2B",32,null,0,1,2,0,2,1,0,0,0,3,0,6,10,0,2,2,1,0,1,1]
[null,"SUCNR1",31.5,null,0,2,0,0,1.5,2,0,0,1,4,1,2,15,1,1,0,1,0,0,0]
[null,"GPR151",31.5,null,0,7,3,0,2.5,0,0,0,0,2,4,0,8,1,2,0,0,0,2,0]
[null,"F2RL1",31.5,null,1,5,0,0,0.5,0,0,0,0,2,2,3,14,0,1,1,0,0,0,2]
[null,"CHRM5",31.5,null,0,3,2,0,1.5,1,0,0,0,2,6,3,11,0,1,0,0,0,0,1]
[null,"TACR2",31,null,0,1,2,0,7,0,0,0,1,6,2,1,9,0,1,1,0,0,0,0]
[null,"P2RY2",31,null,1,1,1,0,5,0,0,1,0,1,3,3,11,0,1,2,1,0,0,0]
[null,"MAS1L",31,null,0,5,1,0,2,0,0,0,0,1,10,1,7,2,1,0,1,0,0,0]
[null,"GPR55",31,null,0,2,1,0,1,1,0,0,1,3,8,1,9,0,0,2,2,0,0,0]
[null,"GPR22",31,null,0,3,1,0,5,1,0,0,0,5,8,0,6,0,0,0,2,0,0,0]
[null,"FFAR3",31,null,0,5,2,0,2,1,0,0,0,3,7,2,8,0,1,0,0,0,0,0]
[null,"CCR8",31,null,0,4,0,0,1,0,0,0,0,2,5,1,17,0,0,0,0,0,0,1]
[null,"CCR6",31,null,1,2,0,0,0,0,0,1,0,5,9,2,7,0,0,1,1,0,1,1]
[null,"GPR35",30,null,0,2,1,1,6,0,1,0,0,3,8,1,6,0,0,1,0,0,0,0]
[null,"P2RY14",29.5,null,0,2,0,0,1.5,1,0,1,0,2,2,3,13,0,1,2,1,0,0,0]
[null,"NMUR1",29.5,null,0,0,1,0,2,1,0,0,0,3,8.5,0,10,0,1,1,2,0,0,0]
[null,"GPR119",29.5,null,0,4,0,0,1.5,0,0,0,0,2,6,0,9,1,0,3,2,0,1,0]
[null,"P2RY13",29,null,0,3,3,1,6,2,0,1,0,3,1,1,5,0,1,0,1,1,0,0]
[null,"NPBWR1",29,null,0,0,1,0,2,6,0,0,0,2,5,4,3,1,1,0,3,0,1,0]
[null,"HTR2B",29,null,0,5,1,0,5,0,0,0,1,5,5,1,2,0,1,2,0,0,1,0]
[null,"HCAR2",29,null,0,6,1,0,0,5,0,1,1,1,2,0,11,0,1,0,0,0,0,0]
[null,"GPR12",29,null,0,2,1,0,3,1,0,0,0,1,5,2,12,0,2,0,0,0,0,0]
[null,"CXCR4",29,null,0,4,0,0,3,1,0,0,0,2,5,5,8,0,1,0,0,0,0,0]
[null,"CRHR2",29,null,0,3,1,0,2,0,0,1,0,5,0,3,11,0,1,2,0,0,0,0]
[null,"CHRM4",29,null,0,2,0,0,1,1,0,0,0,3,6,1,9,0,1,2,2,0,1,0]
[null,"PTGER2",28,null,0,7,0,0,2,1,0,1,0,1,4,2,8,0,0,1,1,0,0,0]
[null,"GPR171",28,null,0,3,0,0,2,0,0,1,0,5,2,2,12,0,1,0,0,0,0,0]
[null,"GPR107",28,null,0,7,1,0,1,0,0,1,0,3,6,1,6,0,0,2,0,0,0,0]
[null,"AVPR2",28,null,0,4,3,0,2,2,0,0,0,3,6,3,1,0,1,0,2,1,0,0]
[null,"ADRA1B",28,null,0,1,1,0,1,0,0,0,0,4,8,3,8,0,0,1,0,0,0,1]
[null,"TAS2R40",27.5,null,1,2,1,0,2.5,0,0,0,0,2,7,3,8,0,0,0,0,1,0,0]
[null,"TAS2R10",27.5,null,0,0,3,0,2.5,0,1,0,0,5,2,3,9,0,1,0,1,0,0,0]
[null,"GPR148",27.5,null,0,1,0,1,1.5,1,0,1,0,3,0,2,14,0,1,2,0,0,0,0]
[null,"F2RL3",27.5,null,0,1,2,2,8,1,0,0,0,1,1.5,1,8,0,1,1,0,0,0,0]
[null,"TAAR8",27,null,0,5,0,0,1,1,0,0,0,1,7,3,7,0,1,1,0,0,0,0]
[null,"GPR153",27,null,0,3,1,2,2,1,0,0,0,5,1,3,4,0,1,2,1,0,0,1]
[null,"FZD9",27,null,0,2,3,0,4,2,0,0,0,4,4,2,3,0,1,2,0,0,0,0]
[null,"FFAR2",27,null,0,1,0,0,3,0,0,0,0,4,3,2,5,0,7,0,1,0,1,0]
[null,"CCR9",27,null,0,1,0,1,1,3,0,0,0,5,1,1,9,0,1,1,3,0,0,0]
[null,"TAAR1",26.5,null,0,3,1,0,2.5,0,0,1,0,4,4,5,4,0,1,0,1,0,0,0]
[null,"MAS1",26.5,null,0,2,2,1,1,1,0,1,0,0,4.5,3,8,1,0,1,1,0,0,0]
[null,"TBXA2R",26,null,0,0,0,1,3,3,1,2,0,1,1,2,6,0,1,5,0,0,0,0]
[null,"TAS2R39",26,null,0,3,0,0,0,0,0,0,0,4,5,2,11,0,0,0,0,0,1,0]
[null,"P2RY4",26,null,0,1,2,2,2,1,0,0,0,5,4,2,4,0,1,2,0,0,0,0]
[null,"OPN3",26,null,0,1,0,0,3,1,0,0,0,4,3,2,9,0,1,1,0,1,0,0]
[null,"GPR31",26,null,0,5,1,0,3,0,0,0,0,3,9,1,3,0,0,0,1,0,0,0]
[null,"GPR132",26,null,0,4,2,0,2,1,0,0,0,3,5,1,4,0,1,1,1,0,0,1]
[null,"FFAR1",26,null,0,0,1,0,6,0,1,0,0,1,7,0,8,0,0,0,1,0,1,0]
[null,"CXCR3",26,null,1,3,5,0,3,1,0,0,0,3,3,1,5,1,0,0,0,0,0,0]
[null,"CCR4",26,null,1,3,0,0,1,2,0,0,0,2,3,3,10,0,1,0,0,0,0,0]
[null,"TAS2R30",25.5,null,0,4,1,0,2.5,3,2,0,0,5,4,0,1,0,1,0,1,0,0,1]
[null,"SSTR5",25.5,null,0,1,1,0,2,1,0,0,0,3,5.5,1,6,0,2,2,0,0,0,1]
[null,"S1PR5",25,null,0,4,1,0,3,1,0,0,0,4,3,1,2,0,1,0,3,1,1,0]
[null,"PTGIR",25,null,1,2,0,0,1,0,0,1,0,2,6,1,7,0,0,3,1,0,0,0]
[null,"OXER1",25,null,0,2,3,1,4,1,1,0,0,3,3,0,4,0,0,0,2,0,1,0]
[null,"GPR19",25,null,2,2,0,0,5,1,1,0,0,2,2,0,6,0,1,1,1,0,1,0]
[null,"GPR18",25,null,0,3,0,0,2,1,0,0,2,4,3,2,6,0,0,2,0,0,0,0]
[null,"CCR7",25,null,0,3,3,1,4,2,0,0,0,3,0,0,4,0,1,3,1,0,0,0]
[null,"ADRB2",25,null,0,3,1,0,3,0,0,2,0,3,4,4,4,0,0,0,1,0,0,0]
[null,"SSTR2",24,null,0,0,1,0,2,0,1,0,0,2,4,2,10,0,0,1,0,0,1,0]
[null,"P2RY12",24,null,1,2,0,0,1,0,0,0,0,5,2,0,10,0,0,0,2,0,0,1]
[null,"GPR52",24,null,0,2,1,0,2,5,0,0,0,3,3,2,4,0,0,0,0,1,0,1]
[null,"GPR25",24,null,0,1,0,0,0.5,0,0,0,0,1,2.5,1,4,0,12,0,2,0,0,0]
[null,"GPR17",24,null,0,3,2,0,1,0,0,2,0,0,8,4,2,0,0,1,1,0,0,0]
[null,"TAS2R3",23.5,null,1,3,1,0,2,1,0,2.5,0,2,2,2,4,0,1,0,1,0,0,1]
[null,"MCHR1",23.5,null,1,3,0,0,0.5,1,0,0,1,0,4,2,6,0,1,1,2,0,1,0]
[null,"TAS2R8",23,null,0,1,1,0,3,1,0,0,0,4,0,1,9,1,1,0,0,1,0,0]
[null,"HCAR1",23,null,1,2,0,0,0,1,0,1,0,3,1,1,10,0,1,0,1,0,1,0]
[null,"GNRHR",23,null,0,2,0,0,4,0,0,0,0,2,7,0,2,0,1,3,1,0,0,1]
[null,"ADORA2A",23,null,0,1,2,0,1,1,1,0,1,2,3,4,3,0,1,2,1,0,0,0]
[null,"MC4R",22.5,null,0,3,2,0,2.5,2,0,1,0,3,3,2,2,0,0,1,1,0,0,0]
[null,"TAS2R7",22,null,0,1,0,0,3,1,0,0,0,3,3,1,9,0,0,0,0,0,1,0]
[null,"TAS2R31",22,null,0,3,3,0,4,1,0,0,0,3,3,0,4,0,0,0,1,0,0,0]
[null,"TAS2R19",22,null,0,0,1,1,3,0,0,0,0,2,8,5,1,0,0,1,0,0,0,0]
[null,"OXTR",22,null,0,1,0,1,0,1,1,0,0,1,4,1,9,0,2,0,0,0,0,1]
[null,"GPRC5A",22,null,0,2,1,0,3,0,0,1,0,4,2,1,5,0,1,0,1,0,0,1]
[null,"FZD5",22,null,1,1,0,0,0,1,0,1,1,3,5,0,4,2,0,3,0,0,0,0]
[null,"GPER",21.5,null,0,0,0,0,3.5,1,0,0,0,2,3,1,7,1,1,1,1,0,0,0]
[null,"GPR1",21.5,null,0,3,2,0,0,0,0,1,0,3,2.5,2,5,0,0,0,2,0,0,1]
[null,"GIPR",21.5,null,1,3,1,0,2,0,0,1,2,2,2.5,0,3,0,1,2,1,0,0,0]
[null,"TAS2R46",21,null,1,2,0,0,2,3,0,0,0,2,4,0,3,1,0,1,1,0,1,0]
[null,"TAS2R20",21,null,0,5,0,0,1,1,0,0,1,3,3,1,3,0,0,1,0,1,0,1]
[null,"GPR68",21,null,0,5,0,0,3,1,0,0,0,4,1,1,3,0,0,2,0,1,0,0]
[null,"GPR183",21,null,0,2,0,1,1,1,0,2,0,2,4,1,4,0,1,1,1,0,0,0]
[null,"GPR173",21,null,2,2,0,2,1,0,0,0,0,3,4,1,2,0,1,0,2,0,1,0]
[null,"C5AR2",21,null,0,1,0,1,0,1,0,0,0,3,2,0,10,0,1,1,1,0,0,0]
[null,"TAS2R50",20.5,null,1,3,0,0,2.5,0,1,1,0,3,1,0,3,1,1,1,0,1,0,1]
[null,"GPR34",20.5,null,0,0,1,1,3.5,1,0,0,0,4,4,1,3,1,0,0,0,0,0,1]
[null,"VIPR1",20,null,1,1,0,0,1,0,0,1,0,3,2,0,8,0,1,1,0,1,0,0]
[null,"TAS2R4",20,null,0,1,0,0,3,1,0,0,0,4,2,1,6,0,1,1,0,0,0,0]
[null,"TAS2R14",20,null,0,1,2,1,1,0,0,0,0,2,4,0,7,0,0,0,2,0,0,0]
[null,"S1PR3",20,null,0,0,2,0,2,0,0,1,0,4,6,1,2,1,0,0,1,0,0,0]
[null,"FZD4",20,null,0,2,0,0,2,0,0,1,0,4,4,1,3,0,0,1,2,0,0,0]
[null,"CYSLTR2",20,null,0,1,2,0,2,0,0,0,0,2,0,1,8,0,1,1,0,0,1,1]
[null,"CHRM1",20,null,0,2,2,0,1,1,0,0,0,2,5,0,6,0,0,0,1,0,0,0]
[null,"ADRA2A",20,null,1,3,0,0,3,2,0,0,0,2,0,0,3,0,1,2,2,0,0,1]
[null,"TAS2R5",19,null,1,1,1,0,1,0,0,0,0,2,3,1,7,0,0,1,1,0,0,0]
[null,"LTB4R",19,null,0,0,0,0,1,0,0,1,0,5,5,0,3,0,2,0,0,1,1,0]
[null,"GPR182",19,null,1,0,1,0,2.5,1,0,0,0,2,1.5,0,6,0,1,0,2,0,0,1]
[null,"FFAR4",19,null,0,1,0,0,0,1,0,0,0,4,3,0,9,0,0,0,0,0,1,0]
[null,"TAS2R13",18.5,null,0,2,2,0,3.5,3,0,0,1,2,2,0,2,0,0,1,0,0,0,0]
[null,"RXFP4",18.5,null,0,3,2,0,1.5,0,0,0,0,3,2,1,5,0,0,1,0,0,0,0]
[null,"LPAR6",18.5,null,0,5,1,0,3.5,0,0,0,0,2,3,0,1,1,1,0,0,0,1,0]
[null,"PTGDR2",18,null,1,1,0,0,7,1,0,0,0,1,1,0,0,0,0,1,0,1,4,0]
[null,"P2RY6",18,null,0,2,1,0,4,1,0,1,0,1,2,2,2,0,1,0,1,0,0,0]
[null,"LPAR2",18,null,0,2,0,0,2,0,0,0,1,2,3,2,5,0,0,0,1,0,0,0]
[null,"HCRTR1",18,null,1,1,2,0,0,0,0,0,0,3,4,0,5,0,1,0,1,0,0,0]
[null,"CXCR5",18,null,1,2,0,0,3,1,0,0,0,2,2,1,6,0,0,0,0,0,0,0]
[null,"GALR2",17.5,null,0,4,2,0,0,0,0,0.5,0,1,5,0,1,0,1,2,1,0,0,0]
[null,"TPRA1",17,null,0,2,0,0,1,0,0,0,0,2,2,2,6,0,1,0,1,0,0,0]
[null,"S1PR2",17,null,1,1,0,0,3,1,0,0,0,1,1,2,4,0,1,1,0,0,0,1]
[null,"PTAFR",17,null,0,1,0,0,0,0,0,1,0,2,6,3,3,0,0,0,1,0,0,0]
[null,"MRGPRE",17,null,0,3,0,0,3,0,0,0,0,2,0,3,5,1,0,0,0,0,0,0]
[null,"TAS2R43",16.5,null,0,1,2,1,5.5,0,0,0,0,2,1,0,2,0,0,1,1,0,0,0]
[null,"MRGPRF",16,null,0,2,0,0,0,5,0,0,0,1,0,2,3,0,1,0,2,0,0,0]
[null,"GPR27",16,null,0,1,1,0,1,0,1,0,0,0,5,1,5,0,0,0,1,0,0,0]
[null,"GPR160",16,null,0,2,1,0,4,0,0,0,0,2,4,1,0,0,0,0,0,1,1,0]
[null,"GPR143",16,null,0,1,4,1,0,0,0,0,0,3,0,2,4,0,1,0,0,0,0,0]
[null,"ADRA2C",16,null,1,3,0,0,1,1,0,0,0,2,0,2,2,0,2,2,0,0,0,0]
[null,"LPAR5",15.5,null,0,0,0,0,3,0,1,0.5,0,1,2,0,2,1,1,1,2,1,0,0]
[null,"MLNR",15,null,0,3,0,1,0,1,1,0,0,1,1,2,3,0,1,1,0,0,0,0]
[null,"CXCR6",15,null,0,3,0,0,0,0,0,0,0,4,1,0,5,0,0,1,1,0,0,0]
[null,"CCR10",15,null,0,3,1,0,2,1,0,0,0,2,1,1,2,0,2,0,0,0,0,0]
[null,"TAS2R42",14.5,null,0,0,1,0,1.5,0,0,1,0,2,2,2,3,0,1,1,0,0,0,0]
[null,"GPR3",14.5,null,1,0,2,0,2.5,0,0,0,1,3,0,0,4,0,1,0,0,0,0,0]
[null,"UTS2R",14,null,0,1,0,0,2,0,0,0,0,2,5,0,2,0,1,0,1,0,0,0]
[null,"NPFFR1",14,null,0,2,0,0,2,1,0,0,0,3,2,0,2,0,1,0,1,0,0,0]
[null,"GPRC5D",14,null,0,1,0,0,2,1,0,1,0,3,2,0,3,0,0,0,0,0,1,0]
[null,"GPR135",14,null,0,2,0,0,1,0,0,0,0,3,4,2,1,0,0,0,1,0,0,0]
[null,"DRD4",14,null,0,1,1,0,0,1,0,0,1,0,2,1,3,0,0,1,1,0,2,0]
[null,"MRGPRD",13.5,null,0,3,0,0,1,0,0,0.5,0,0,0,2,5,0,1,1,0,0,0,0]
[null,"GPR21",13.5,null,0,1,0,0,1.5,0,0,0,0,2,3,0,1,1,3,1,0,0,0,0]
[null,"ADRB1",13,null,0,3,0,0,1,1,0,0,0,0,1,1,5,0,0,1,0,0,0,0]
[null,"MC1R",12,null,1,2,0,0,2,0,0,0,0,3,2,0,1,0,0,0,0,0,0,1]
[null,"LTB4R2",12,null,0,3,1,0,0,0,0,0,0,0,0,1,3,0,1,0,1,1,1,0]
[null,"GPR88",12,null,0,3,0,0,2,1,0,0,0,0,1,0,4,0,0,0,0,0,0,1]
[null,"ADRB3",12,null,0,0,0,0,4,0,0,0,0,0,6,0,1,0,0,0,1,0,0,0]
[null,"CCRL1",11,null,1,0,1,0,6,0,1,0,0,0,0,2,0,0,0,0,0,0,0,0]
[null,"GPR62",11,null,0,3,0,0,0,0,0,1,0,3,1,0,1,0,1,1,0,0,0,0]
[null,"GPBAR1",11,null,0,0,0,0,1,1,0,0,0,3,2,0,1,0,1,1,1,0,0,0]
[null,"ADORA2B",11,null,0,1,0,0,1,1,0,0,0,1,1,0,4,1,0,0,1,0,0,0]
[null,"GPR82",10.5,null,2,1,0,0,1.5,0,0,0,0,3,1,1,0,1,0,0,0,0,0,0]
[null,"GPR146",10,null,0,1,0,0,7,0,0,0,0,2,0,0,0,0,0,0,0,0,0,0]
[null,"GALR3",10,null,1,3,0,0,0,0,0,0,0,1,1,0,2,0,0,0,1,0,1,0]
[null,"CCRL2",10,null,0,4,2,0,3,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0]
[null,"CXCR7",9,null,0,0,1,0,6,0,0,0,0,0,0,2,0,0,0,0,0,0,0,0]
[null,"GPR150",9,null,2,1,0,0,1,1,0,0,0,0,3,0,0,0,0,1,0,0,0,0]
[null,"GPR157",8,null,0,0,0,0,0,0,0,0,0,1,1,2,3,0,0,1,0,0,0,0]
[null,"CCBP2",6,null,0,0,0,0,2,0,0,0,0,0,0,4,0,0,0,0,0,0,0,0]
[null,"PTGER1",6,null,0,1,2,0,0,0,0,0,1,0,0,0,2,0,0,0,0,0,0,0]
[null,"NPY6R",6,null,0,0,0,0,0,2,0,0,0,0,4,0,0,0,0,0,0,0,0,0]
[null,"KISS1R",6,null,3,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0]
[null,"MRGPRG",5,null,0,0,0,0,2,0,0,0,0,3,0,0,0,0,0,0,0,0,0,0]
[null,"GNRHR2",5,null,0,0,0,0,0,1,0,0,0,3,0,0,1,0,0,0,0,0,0,0]
[null,"GCGR",3,null,0,0,2,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,"P2RY11",2,null,0,0,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,"ADGRE4P",0,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,"TAAR3",0,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,"GPR33",0,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]

{"sheet":"Mutation Events","index":4,"n_rows":393,"n_cols":314,"rows_kept":281,"cut":true,"bounds":{"rows_first":125,"rows_last":31,"rows_between":125,"halvings":4},"flags":["formulas_cached_only"]}
["The number of somatic mutation events for each GPCR, within each TCGA cancer cohort",null,"ACC",null,10,2,2,16,152,3,0,1,70,1,0,null,"BLCA","Totals",24,8,2,2,1489,118,4,3,850,33,12,null,"BRCA","Totals",62,12,9,3,1020,67,0,0,409,13,0,0,null,"CESC","Totals",0,0,2,0,91,3,0,0,49,3,1,0,null,"COAD","Totals",112,38,7,6,1516,72,0,7,790,11,0,0,null,"ESCA","Totals",0,0,0,0,174,7,0,2,73,5,1,0,null,"KICH","Totals",0,0,0,0,35,0,0,0,12,0,0,0,null,"KIRP","Totals",3,8,3,1,102,3,0,0,51,2,0,0,null,"KIRC","Totals",29,30,1,3,227,9,0,0,71,14,1,0,null,"LIHC","Totals",1875,84,0,3,477,18,1,11,175,37,5,0,null,"LUAD","Totals",131,45,6,4,3980,290,12,22,1622,113,15,0,null,"LSQC","Totals",14,5,1,0,1055,83,0,4,440,19,1,0,null,"SKCM","Totals",38,4,7,0,6140,453,6,7,4514,154,25,0,null,"OV","Totals",3,0,1,0,106,5,0,0,43,1,0,0,null,"PAAD","Totals",6,3,25,0,419,16,0,1,171,8,2,0,null,"PRAD","Totals",12,7,5,0,551,22,0,2,202,8,2,0,null,"STAD","Totals",32,11,2,1,469,19,0,0,178,8,1,0,null,"TGCT","Totals",3,2,5,0,52,1,0,1,16,0,0,0,null,"THCA","Totals",12,2,5,1,119,2,0,0,47,2,1,0,null,"UCS","Totals",11,0,1,0,165,8,0,1,55,4,1,0,{"$nulls":3},"Totals number of mutation events per GPCR across all cancers surveyed"]
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["Number of replicates (n) are the same as on the previous sheet",null,null,"ADCYAP1R1",0,0,0,0,0,0,0,0,0,0,0,null,null,"ADCYAP1R1",1,0,0,0,5,0,0,0,2,1,0,null,null,"ADCYAP1R1",4,2,0,0,0,0,0,0,2,0,0,0,null,null,"ADCYAP1R1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADCYAP1R1",0,0,0,0,0,1,0,0,0,0,0,0,null,null,"ADCYAP1R1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADCYAP1R1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADCYAP1R1",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"ADCYAP1R1",4,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADCYAP1R1",6,0,0,0,1,1,0,0,0,0,0,0,null,null,"ADCYAP1R1",1,0,0,0,16,0,0,0,12,0,0,0,null,null,"ADCYAP1R1",0,0,0,0,8,0,0,0,2,1,0,0,null,null,"ADCYAP1R1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADCYAP1R1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADCYAP1R1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADCYAP1R1",0,0,0,0,2,0,0,0,0,0,0,0,null,null,"ADCYAP1R1",0,0,0,0,0,0,0,0,1,0,0,0,null,null,"ADCYAP1R1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADCYAP1R1",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"ADCYAP1R1",0,0,0,0,0,0,0,0,0,0,0,0,{"$nulls":3},"ADCYAP1R1",16,2,0,0,34,2,0,0,19,2,0]
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["Gene names are based on Hg19, which was used for TCGA mutation analysis; sheet 2 shows IUPHAR gene names",null,null,"ADORA2A",0,0,0,0,0,0,0,0,0,0,0,null,null,"ADORA2A",0,0,0,0,0,1,0,0,2,0,0,null,null,"ADORA2A",0,0,0,0,2,0,0,0,0,0,0,0,null,null,"ADORA2A",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADORA2A",0,0,0,0,1,0,0,0,1,0,0,0,null,null,"ADORA2A",0,0,0,0,1,0,0,0,1,0,0,0,null,null,"ADORA2A",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"ADORA2A",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"ADORA2A",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADORA2A",1,0,0,0,1,0,0,0,1,0,0,0,null,null,"ADORA2A",0,0,0,0,3,0,0,0,0,0,0,0,null,null,"ADORA2A",0,0,0,0,5,0,0,0,2,0,0,0,null,null,"ADORA2A",0,0,0,0,2,0,0,0,9,1,0,0,null,null,"ADORA2A",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADORA2A",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"ADORA2A",0,0,0,0,2,0,0,0,0,0,0,0,null,null,"ADORA2A",0,0,0,0,1,0,0,0,1,0,0,0,null,null,"ADORA2A",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADORA2A",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADORA2A",0,0,0,0,0,0,0,0,0,0,0,0,{"$nulls":3},"ADORA2A",1,0,0,0,21,1,0,0,17,1,0]
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["Details of mutation events for each GPCR in each TCGA sample in each cancer type is downloadable at     insellab.github.io",null,null,"ADORA3",0,0,0,0,0,0,0,0,0,0,0,null,null,"ADORA3",0,0,0,0,5,0,0,0,0,0,0,null,null,"ADORA3",0,0,0,0,4,0,0,0,1,0,0,0,null,null,"ADORA3",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADORA3",0,0,0,0,5,0,0,0,0,0,0,0,null,null,"ADORA3",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADORA3",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADORA3",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADORA3",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADORA3",5,2,0,0,2,0,0,0,1,0,0,0,null,null,"ADORA3",0,0,0,0,3,1,0,0,6,4,0,0,null,null,"ADORA3",0,0,0,0,1,0,0,0,1,0,0,0,null,null,"ADORA3",0,0,0,0,16,3,0,0,18,0,0,0,null,null,"ADORA3",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADORA3",0,0,0,0,2,0,0,0,0,0,1,0,null,null,"ADORA3",0,0,0,0,3,0,0,0,1,0,0,0,null,null,"ADORA3",0,0,0,0,2,0,0,0,1,0,0,0,null,null,"ADORA3",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADORA3",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"ADORA3",0,0,0,0,0,0,0,0,0,0,0,0,{"$nulls":3},"ADORA3",5,2,0,0,43,4,0,0,29,4,1]
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[{"$nulls":3},"TSHR",0,0,0,0,0,0,0,0,1,0,0,null,null,"TSHR",0,0,0,0,8,0,0,0,1,0,0,null,null,"TSHR",0,0,0,0,9,0,0,0,2,0,0,0,null,null,"TSHR",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"TSHR",0,0,0,0,7,0,0,0,1,0,0,0,null,null,"TSHR",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"TSHR",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"TSHR",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"TSHR",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"TSHR",7,2,0,0,0,0,0,0,0,0,0,0,null,null,"TSHR",2,0,0,0,21,2,0,0,11,0,0,0,null,null,"TSHR",0,0,0,0,4,0,0,0,1,1,0,0,null,null,"TSHR",1,0,0,0,22,1,0,0,13,0,0,0,null,null,"TSHR",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"TSHR",0,0,0,0,2,0,0,0,0,1,0,0,null,null,"TSHR",0,0,0,0,2,0,0,0,0,0,0,0,null,null,"TSHR",0,0,0,0,3,0,0,0,1,0,0,0,null,null,"TSHR",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"TSHR",0,0,0,0,1,0,0,0,1,0,0,0,null,null,"TSHR",0,0,0,0,2,0,0,0,0,0,0,0,{"$nulls":3},"TSHR",10,2,0,0,84,3,0,0,32,2,0]
[{"$nulls":3},"UTS2R",0,0,0,0,0,0,0,0,0,0,0,null,null,"UTS2R",0,0,0,0,1,0,0,0,1,0,0,null,null,"UTS2R",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"UTS2R",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"UTS2R",0,0,0,0,2,0,0,0,4,0,0,0,null,null,"UTS2R",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"UTS2R",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"UTS2R",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"UTS2R",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"UTS2R",2,0,0,0,0,0,0,0,1,0,0,0,null,null,"UTS2R",1,0,0,0,4,0,0,0,1,0,0,0,null,null,"UTS2R",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"UTS2R",0,0,0,0,2,0,0,0,3,0,0,0,null,null,"UTS2R",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"UTS2R",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"UTS2R",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"UTS2R",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"UTS2R",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"UTS2R",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"UTS2R",0,0,0,0,0,0,0,0,0,0,0,0,{"$nulls":3},"UTS2R",3,0,0,0,12,0,0,0,10,0,0]
[{"$nulls":3},"VIPR1",0,0,0,0,1,0,0,0,0,0,0,null,null,"VIPR1",0,0,0,0,1,0,0,0,7,0,0,null,null,"VIPR1",0,0,0,0,1,0,0,0,2,0,0,0,null,null,"VIPR1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"VIPR1",0,0,0,0,1,0,0,0,1,0,0,0,null,null,"VIPR1",0,0,0,0,0,0,0,0,1,0,0,0,null,null,"VIPR1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"VIPR1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"VIPR1",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"VIPR1",10,0,0,0,0,0,0,0,1,0,0,0,null,null,"VIPR1",0,0,0,0,1,0,0,0,2,1,0,0,null,null,"VIPR1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"VIPR1",0,0,0,0,10,1,0,0,8,0,0,0,null,null,"VIPR1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"VIPR1",0,0,0,0,0,0,0,0,0,1,0,0,null,null,"VIPR1",0,0,0,0,1,0,0,0,1,0,0,0,null,null,"VIPR1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"VIPR1",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"VIPR1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"VIPR1",0,0,0,0,0,0,0,0,0,0,0,0,{"$nulls":3},"VIPR1",10,0,0,0,18,1,0,0,23,2,0]
[{"$nulls":3},"VIPR2",0,0,0,0,0,0,0,0,0,0,0,null,null,"VIPR2",0,0,0,0,1,3,0,0,3,2,0,null,null,"VIPR2",0,0,0,0,0,1,0,0,0,0,0,0,null,null,"VIPR2",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"VIPR2",1,0,0,0,4,0,0,0,2,0,0,0,null,null,"VIPR2",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"VIPR2",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"VIPR2",1,0,0,0,0,0,0,0,0,0,0,0,null,null,"VIPR2",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"VIPR2",9,0,0,0,1,0,0,0,1,0,0,0,null,null,"VIPR2",0,0,0,0,4,0,0,0,1,0,0,0,null,null,"VIPR2",0,0,0,0,3,0,0,0,0,0,0,0,null,null,"VIPR2",0,0,0,0,9,0,0,0,9,3,0,0,null,null,"VIPR2",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"VIPR2",0,0,0,0,1,0,0,0,1,0,0,0,null,null,"VIPR2",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"VIPR2",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"VIPR2",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"VIPR2",0,0,0,0,0,0,0,0,1,0,0,0,null,null,"VIPR2",0,0,0,0,0,0,0,0,0,0,0,0,{"$nulls":3},"VIPR2",11,0,0,0,25,4,0,0,18,5,0]
[{"$nulls":3},"XCR1",0,0,0,0,0,0,0,0,0,0,0,null,null,"XCR1",0,0,0,0,0,0,0,0,2,0,0,null,null,"XCR1",0,0,0,0,6,0,0,0,1,0,0,0,null,null,"XCR1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"XCR1",1,0,0,0,3,0,0,0,1,0,0,0,null,null,"XCR1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"XCR1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"XCR1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"XCR1",0,0,0,0,1,0,0,0,0,0,0,0,null,null,"XCR1",4,0,0,0,0,0,0,0,0,0,0,0,null,null,"XCR1",0,0,0,0,6,0,0,0,3,0,0,0,null,null,"XCR1",0,0,0,0,2,0,0,0,0,0,0,0,null,null,"XCR1",0,0,0,0,7,0,0,0,15,0,0,0,null,null,"XCR1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"XCR1",0,0,0,0,3,0,0,0,0,0,0,0,null,null,"XCR1",0,0,0,0,2,0,0,0,0,0,0,0,null,null,"XCR1",1,0,0,0,0,0,0,0,0,0,0,0,null,null,"XCR1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"XCR1",0,0,0,0,0,0,0,0,0,0,0,0,null,null,"XCR1",0,0,0,0,0,0,0,0,0,0,0,0,{"$nulls":3},"XCR1",6,0,0,0,30,0,0,0,22,0,0]

{"sheet":"GPCR CNV","index":5,"n_rows":392,"n_cols":161,"rows_kept":392,"flags":["formulas_cached_only"]}
["The number of tumors within each cancer type that show CNV of the type indicated",null,"ACC","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"BLCA","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"BRCA","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"CESC","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"COAD","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"ESCA","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"KICH (kidney chromophobe)","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"KIRC (kidney clear cell)","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"KIRP (kidney ppillary)","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"LIHC","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"LUAD","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"LSQC","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"SKCM","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"OV","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"PAAD","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"PRAD","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"STAD","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"TGCT","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"THCA","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification",null,"UCS","Gene Symbol","Homozygous deletion","Single copy deletion","diploid copy number","low level amplification","high level amplification"]
[null,null,"n = 90","ACKR2",0,22,57,11,0,null,"n = 408","ACKR2",2,90,194,116,6,null,"n = 1080","ACKR2",5,306,668,99,2,null,"n = 295","ACKR2",4,108,150,32,1,null,"n = 451","ACKR2",0,65,347,39,0,null,"n = 184","ACKR2",0,114,55,14,1,null,"n = 66","ACKR2",0,9,49,7,1,null,"n = 528","ACKR2",56,409,57,6,0,null,"n = 288","ACKR2",0,25,191,72,0,null,"n = 370","ACKR2",1,53,270,43,3,null,"n = 516","ACKR2",1,237,245,33,0,null,"n = 501","ACKR2",4,421,69,7,0,null,"n = 367","ACKR2",0,66,236,62,3,null,"n = 579","ACKR2",2,182,284,101,10,null,"n = 184","ACKR2",0,46,131,6,1,null,"n = 492","ACKR2",0,11,442,38,1,null,"n = 441","ACKR2",2,135,273,30,1,null,"n = 150","ACKR2",0,37,88,25,0,null,"n = 499","ACKR2",0,3,493,3,0,null,"n = 56","ACKR2",0,30,16,10,0]
["Number of replicates (n) in each cancer type are indicated below the cancer name",null,null,"ACKR3",1,16,59,14,0,null,null,"ACKR3",13,190,188,17,0,null,null,"ACKR3",8,300,704,68,0,null,null,"ACKR3",11,113,162,9,0,null,null,"ACKR3",3,19,344,85,0,null,null,"ACKR3",3,43,103,34,1,null,null,"ACKR3",0,49,16,1,0,null,null,"ACKR3",3,44,408,69,4,null,null,"ACKR3",4,8,231,44,1,null,null,"ACKR3",0,57,269,43,1,null,null,"ACKR3",3,55,329,125,4,null,null,"ACKR3",4,152,269,76,0,null,null,"ACKR3",3,81,222,61,0,null,null,"ACKR3",6,156,262,141,14,null,null,"ACKR3",0,8,153,22,1,null,null,"ACKR3",3,32,449,8,0,null,null,"ACKR3",6,61,313,61,0,null,null,"ACKR3",0,11,102,37,0,null,null,"ACKR3",1,11,486,1,0,null,null,"ACKR3",0,8,25,22,1]
[{"$nulls":3},"ACKR4",0,21,51,18,0,null,null,"ACKR4",1,22,188,190,7,null,null,"ACKR4",0,109,722,241,8,null,null,"ACKR4",1,7,97,170,20,null,null,"ACKR4",0,33,351,67,0,null,null,"ACKR4",1,20,67,83,13,null,null,"ACKR4",0,8,51,7,0,null,null,"ACKR4",0,99,359,67,3,null,null,"ACKR4",0,9,183,96,0,null,null,"ACKR4",0,43,282,43,2,null,null,"ACKR4",2,120,276,115,3,null,null,"ACKR4",1,27,106,316,51,null,null,"ACKR4",0,61,236,70,0,null,null,"ACKR4",0,33,190,319,37,null,null,"ACKR4",0,19,143,22,0,null,null,"ACKR4",3,8,413,61,7,null,null,"ACKR4",2,48,276,112,3,null,null,"ACKR4",0,24,90,36,0,null,null,"ACKR4",0,4,493,2,0,null,null,"ACKR4",0,9,20,25,2]
["Gene names as used on Affy SNP arrays for CNV; sheet 2 shows IUPHAR gene names",null,null,"ADCYAP1R1",0,6,35,48,1,null,null,"ADCYAP1R1",2,19,207,171,9,null,null,"ADCYAP1R1",0,112,622,329,17,null,null,"ADCYAP1R1",1,23,227,43,1,null,null,"ADCYAP1R1",0,2,194,253,2,null,null,"ADCYAP1R1",1,10,53,110,10,null,null,"ADCYAP1R1",0,1,41,24,0,null,null,"ADCYAP1R1",0,2,354,172,0,null,null,"ADCYAP1R1",0,1,114,172,1,null,null,"ADCYAP1R1",0,15,237,115,3,null,null,"ADCYAP1R1",3,28,211,262,12,null,null,"ADCYAP1R1",2,64,191,235,9,null,null,"ADCYAP1R1",0,22,140,199,6,null,null,"ADCYAP1R1",5,142,252,161,19,null,null,"ADCYAP1R1",0,3,126,52,3,null,null,"ADCYAP1R1",0,3,383,101,5,null,null,"ADCYAP1R1",0,10,214,207,10,null,null,"ADCYAP1R1",0,3,22,124,1,null,null,"ADCYAP1R1",0,0,481,18,0,null,null,"ADCYAP1R1",0,10,22,24,0]
[{"$nulls":3},"ADORA1",0,13,63,13,1,null,null,"ADORA1",0,63,220,122,3,null,null,"ADORA1",0,17,248,683,132,null,null,"ADORA1",0,7,137,148,3,null,null,"ADORA1",0,45,309,95,2,null,null,"ADORA1",0,21,80,81,2,null,null,"ADORA1",0,51,14,1,0,null,null,"ADORA1",0,33,436,58,1,null,null,"ADORA1",0,20,250,18,0,null,null,"ADORA1",0,6,93,233,38,null,null,"ADORA1",0,16,134,335,31,null,null,"ADORA1",0,26,223,240,12,null,null,"ADORA1",0,17,148,184,18,null,null,"ADORA1",0,51,232,255,41,null,null,"ADORA1",0,8,120,53,3,null,null,"ADORA1",1,4,455,31,1,null,null,"ADORA1",0,21,287,127,6,null,null,"ADORA1",0,3,77,70,0,null,null,"ADORA1",0,3,468,24,4,null,null,"ADORA1",0,4,15,36,1]
["CNV for each GPCR in each TCGA sample in each cancer type is downloadable at     insellab.github.io",null,null,"ADORA2A",1,43,40,5,1,null,null,"ADORA2A",2,138,188,73,7,null,null,"ADORA2A",0,453,487,127,13,null,null,"ADORA2A",0,63,198,34,0,null,null,"ADORA2A",1,147,287,16,0,null,null,"ADORA2A",0,69,78,35,2,null,null,"ADORA2A",0,8,39,19,0,null,null,"ADORA2A",0,40,447,40,1,null,null,"ADORA2A",1,61,221,5,0,null,null,"ADORA2A",1,74,243,50,2,null,null,"ADORA2A",1,205,228,77,5,null,null,"ADORA2A",1,84,167,235,14,null,null,"ADORA2A",1,38,197,129,2,null,null,"ADORA2A",0,375,128,59,17,null,null,"ADORA2A",0,47,130,7,0,null,null,"ADORA2A",3,52,430,6,1,null,null,"ADORA2A",0,146,257,36,2,null,null,"ADORA2A",1,33,62,53,1,null,null,"ADORA2A",0,87,410,2,0,null,null,"ADORA2A",0,28,10,17,1]
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