The PDFset includes:

• Supplementary Materials and Methods
• Fig. S1. Analytic subsets and microglial gene sets.
• Fig. S2. Antemortem sleep fragmentation and expression of microglia marker genes in Galatro and NeuroExpresso microglial gene sets.
• Fig. S3. Antemortem sleep fragmentation and expression of shared and unshared microglial marker genes from the HuMi_Aged, Galatro, and NeuroExpresso microglial gene sets.
• Fig. S4. Antemortem circadian regularity and expression of microglial marker genes.
• Fig. S5. Antemortem sleep fragmentation and expression of astrocytic marker genes.
• Fig. S6. Representative photomicrographs of microglial morphological stages.
• Fig. S7. Summary diagram.
• Legend for table S1
• Table S2. Antemortem sleep fragmentation and composite expression of aging-enriched microglial genes: Adjustment for neuropathology.
• Table S3. Antemortem sleep fragmentation, composite expression of genes characteristic of aged microglia, and proportion of activated microglia.
• Table S4. Sleep fragmentation, expression of microglial genes, microglial activation, and composite global cognition proximate to death.
• References (44–55)

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Other Supplementary Material for this manuscript includes the following:

• Table S1 (Microsoft Excel format). Antemortem sleep fragmentation and expression of microglia and astrocyte marker genes: Gene level results.