The PDFset includes:

• Note S1. Frequency shifting of the tagged photons.
• Note S2. Mathematical description of GePGS-guided optical focusing inside scattering media.
• Note S3. Minimizing the impact of the fast motions in scattering media.
• Note S4. Curvature compensation and pixel matching.
• Note S5. SNR of the averaged differential hologram.
• Note S6. Filtering out the photons tagged by the GePGS from noise photons.
• Fig. S1. Fluorescence spectra of DrBphP-PCM in the Pr state (OFF; red line) and after photoconversion to the Pfr state (ON; black line).
• Fig. S2. Calculation of the binary amplitude map displayed on the DMD.
• Fig. S3. DMD curvature compensation and pixel matching between the DMD and the camera.
• Fig. S4. Relationship between the detected signals of tagged photons and the total cycle number.
• Fig. S5. Fluorescence imaging of DrBphP-PCM in live neurons.
• Fig. S6. Normalized intensity distribution of the optical foci inside the brain slices.

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Other Supplementary Material for this manuscript includes the following:

• Movie S1 (.mp4 format). Principle of GePGS-guided optical focusing inside scattering media.
• Movie S2 (.mp4 format). Time-reversed focusing inside mouse tumors in vivo.