The PDFset includes:

• Fig. S1. Details of the screening strategy used for studying the role of lncRNAs in neuronal activity and down-regulation in culture.
• Fig. S2. NeuroLNC coding potential, conservation, and locus organization.
• Fig. S3. Specificity of the RNA-FISH approach and expression of neuroLNC in rodent cultures and in adult human brain.
• Fig. S4. Controls for the calcium dynamics experiments.
• Fig. S5. Controls and additional information concerning Fig. 5.
• Fig. S6. NeuroLNC overexpression does not affect the expression of the mRNAs that encode for calcium-related pathways, neuronal activity, or synaptic scaffolds.
• Fig. S7. Schematic representation summarizing the function of NeuroLNC in the nucleus of neurons.

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Other Supplementary Material for this manuscript includes the following:

• Data S1 (Microsoft Excel format). Summary of data used here, see first sheet for details.