This PDF file includes:

• Fig. S1. Common noncoding variants in and around CTNNB1 show significant association signals with BMI in GIANT UK Biobank study.
• Fig. S2. Genetic mutations in the CTNNB1 gene in young obese and control subjects.
• Fig. S3. Phenotypes of APBKO mice.
• Fig. S4. Metabolic parameters in ABKO mice fed normal chow diet at young and old ages.
• Fig. S5. Food intake, fecal calorie excretion, and energy expenditure in ABKO mice fed HFD.
• Fig. S6. The expression changes of genes involved in adipogenesis and the percentage changes of progenitors in adipose tissues of ABKO mice fed HFD.
• Fig. S7. Cell viability of Saa3-treated preadipocytes and the expression of secreted factors in Saa3-treated macrophages.
• Table S1. The BMI association signals of common variants in and around CTNNB1 from GIANT UK Biobank GWAS.
• Table S2. Rare missense variants in the CTNNB1 gene in young, severely obese cases and controls.
• Table S3. The clinical parameters related to obesity in gain-of-function CTNNB1 carriers.
• References (47, 48)

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