This PDF file includes:

• Section S1. Contact scaling of random fractal chain
• Section S2. Granular and porous packing of SRRW
• Section S3. Tree domains and TADs
• Section S4. Non-Gaussian statistics
• Section S5. Effect of α on the statistics of tree domains
• Section S6. Chromatin scanning transmission electron microscopy
• Section S7. Heat shock experiments across multiple cell lines
• Section S8. Histone modification affects fractal dimension D
• Fig. S1. Contact probabilities of RWs and LFs in 2D and 3D space.
• Fig. S2. Comparing packing cross sections of confined SRRW and RW.
• Fig. S3. Structure of local SRRW segment and ensemble-averaged contact map.
• Fig. S4. End-to-end distance distributions of 100-kb SRRW segment (green) and of 100-kb RW segment (red).
• Fig. S5. Effect of α on the tree domains.
• Fig. S6. D and s from the modeled chromatin at varying α.
• Fig. S7. ChromEM sample preparation and STEM imaging on A549 cells.
• Fig. S8. ChromEM sample preparation and TEM imaging on BJ cells.
• Fig. S9. Heat shock increases fractal dimension D across multiple cell lines.
• Fig. S10. Histone deacetylase inhibitor valproic acid decreases fractal dimension D.

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