125 351 Contig_333-2 PGPAPVQALIQTEFAGRPMTFTNWKMHRKIAQSTIRKKAFEQQIVAEATELVEIFLTQYFNPAHELTVAAANVICALCFGKRYGHLQRVDEFGPTVMPWLQS--F-PNNKEFFKFVHDKVEQHRETFPDV-TRDMSDAFIGVHNGLTSDHTEGTVSDLIGAGLDTVSTALHWLLLLLAKHPGMQTKLQELIDQEVGRDRLPSVEDRAHLAYVDAFIYETMRFTSFVPITIPHSTTSDVTIEGCHIPKDTVVFINQWSINHDPLKWKEPHIFDPSRFLDEDGCLDKDITNNVMIFSAGKRRCIGDQIAKVEMFLFFAILLHQCSFEKCPTETLNSYGLTLKPLNYKISAKLR Contig_333-1 PGPAPVQALIQTEFAGRPLTFTNWKVHRKIAHSSLRKKAFEQHITAEAMELVHAFLGQYFDPAHEFTVAAANVMCALCFGRRYGHLKRLDKFGETIMPWLQS--F-PNNDEFFTYVRDKVWQHRETFPDV-TRDMTDAIINVDSGLSKEFSEATMTDLIGAGQDTVSTAMQWIILLLVKHPDIQAKLQTAIDKAVGPDRLPTMEDRHNMPLLDAFIYEMMRFTSFVPVTIPHSTTADVTIEGLHIPKDTVVFVNQWSVNHDPLKWKDPHMFDPTRFLDENGALDRDLTSSVLIFSTGKRRCIGDHIAKAEVFLFTAILLHQCCFESDS-ASLDSYGLTLKPLHSSLRAKLR CYP1C1_Danre PGPAPLKALVQTEFAGRPLTFTNWKTHRKVAQSTLRRKTFEQHVVGEAMDLVQKFLGRHFNPAHEATVAAANVICALCFGKRYGHLGRVNKFGETVMPWLQS--F-PNNKEFFNYVKDKVLQHRDTYPDV-TRDMSDAIIGVESTLTKDFVESTVTDLIGAGQDTVSTAMQWMLLLLVKYPSIQSKLQEQIDKVVGRDRLPSIEDRCNLAYLDAFIYETMRFTSFVPVTIPHSTTSDVTIEGLHIPKDTVVFINQWSVNHDPQKWSDPHIFNPSRFLDENGALNKDLTSSVMIFSTGKRRCIGEQIAKVEVFLFSAILLHQCKFERDPSQSMDSYGLALKPLHYTISAKLR CYP1B1_Hum PGPAPLQALVQSAFADRPMAFGHWKVQRRAAHSMMRRQVLEGHVLSEARELVALLVGAFLDPRPLTVVAVANVMSAVCFGCRYSHLSHNEEFGRTVMPWLQY--F-PNNRNFSNFILDKFLRHCESLPGAAPRDMMDAFILSGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEKMNSYGLTIKPKSFKVNVTLR Contig_2783 PGPPPIQALVKPDFAGRPVAFNTWKVHRRVAQSTLRKKTFERHILCEFKELLQLMVHRYFSPLPYLVVSTANIMSALCFGKRYPYVGRNDQFTQTVMPWLQY--F-PNNRDFNAFVRDKVAEHRKTLSGT-VRDMTDAFIVAGATREKDLVTPVVTDVFGASQDTLSTAQ--------QFPEMQQRLQEEVGRVVDRSRLPTIEDQPRLPYVMAFIYEVMRLSSFVPLTIPHATTTDTSIRGHALPKNTVVFINQWSINHDPKLWRDPDTFDPLRFLMADGALNKDLTSSVLIFSLGKRRCIGEELSKLQLFLFTSLIAHQCNIATDPARSLDNYGLTLKPHPYHVAVTLR CYP1B_Danre PGPSPVEALVKTDFAGRPMAFGNWKLHRKVAQSTVRKQTFEKHIVSEIGELIRLFLQQFFQPHRYLVVSVANTMSAVCFGNRYAYVGRNDQFTKTVMPWMQY--F-PNNKEFCAFIELKVSEHRKTIPSH-VRDMTDAFIVAGVSLDKEFVPPTISDIFGASQDTLSTALQWIILLLVRYPEIQKRLQEDVDRVVDRSRLPTIADQPHLPYLMAFIYEVMRFTSFTPLTIPHSTTKDTSINGYPIPKDTVIFVNQWSLNHDPTKWDQPEVFNPQRFLDEDGSLNKDLTTNVLIFSLGKRRCIGEDVSKIQLFLFTSVLVHQCSFKAE--SNMDEYGLTLKPKPFKVSVTAR CYP1D1_Danre PGPPPIEALVRDAFAGRPMTFSEWVLHKKICKNALRSCLLEERICVEAIDMVETLKDSGIDPVQLLVTSVANVVCTLCFGKRYSHVHINNEVLRLFFPIFRY--L-PSINRMNNFMERNIMEHLVNFTNC-IRDITDALIAM-AVLSNSQIVHSVIDIFGAGFDTIITGLQWSLLYLIKFPNIQDKIVQEIDNQVGMDRLPQFKDRPNMPYTEAFINEVFRHASYMPFTIPHCTTENITLNGYFIPKDTCVFINQYQVNHDIEIWDDPESFRPERFLTLSGHLNKSLTEKVMIFGMGIRRCLGDNIARLEMFVFLTTLLHRLHIENVPGQDLSTFGLTMKPRPYRIKIIPR CYP1A_Danre PGPPPIQALLKEEFSGRPLAFSTWRARRKLALNALRSCALEEHISNEGLYLVQRLHDGSFDPFRHIVVSVANVICGICFGRRHSHVNMSDEFGKIVIPFLRI--L-PSNERFSKFMKRLVMEHYDTFKDN-IRDITDSLINHNLQVSDEKIVGIVNDLFGAGFDTISTALSWAVVYLVHYPEVQERLQRELDEKIGKDRTPLLSDRANLPLLESFILEIFRHSSFLPFTIPHCTSKDTSLNGYFIPKDTCVFVNQWQVNHDPELWKDPSSFIPDRFLTADTELNKLEGEKVLVFGLGKRRCIGESIGRAEVFLFLAILLQRLKFTGMPGEDMTEYGLTMKHKRCLLRVTPQ CYP1A1_Hum PGPGPLQALVRDDFKGRPMSFSPWAARRRLAQNGLKSCYLEEHVSKEAEVLISTLQPGHFNPYRYVVVSVTNVICAICFGRRYDHVNLNNNFGEVVIPILRY--L-PNNEKFYSFMQKMVKEHYKTFKGH-IRDITDSLIEHNVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVDMTIYGLTMKHACCEH-FQMQ CYP1_Mouse PGPGPFQALVRDDFKGRPMTFNPWAARRRLAQDALKSCYLEEHVSKEANHLVSKLQVGHFEPVSQVVESVANVIGAMCFGKNFPRVNNSKDFVENVFPVLRY--L-PNNDNFVLFLQKTVQEHYQDFKNS-IQDITSALFKHGGLIPEEKIVNIVNDIFGAGFDTVTTAITWSILLLVTWPNVQRKIHEELDTVVGRDRQPRLSDRPQLPYLEAFILEIYRYTSFVPFTIPHSTTRDTSLNGFHIPKERCIYINQWQVNHDEKQWKDPFVFRPERFLTNNSAIDKTQSEKVMLFGLGKRRCIGEIPAKWEVFLFLAILLQHLEFSVPPGVDLTNYGLTMKPGTCEH-VQAW CYP17_Hum KSLSPLEVLIKKDFSGRPIAFADWQLHRRLAMATFADQKLEKIICQEISTLCDMLAGQSIDISFPVFVAVTNVISLICFNTSYKNQNYNEGIIDNLVPWLKI--FPNK--IRNDLLNKILENYKEKFSDS-ITNMLDTLMQADSELSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGSLEIPKVVFLIDSFKVKIKVR CYP17_Mouse RSLFPLEVLVKKEFSGRPVAFADWQLHRKLVFSTFSDQKLEKMICQEANSLCDLILGESRDLSTLIFKSVINIICTICFNISFENQTFTEGIVDVLFPWLKI--FPNK--IREKTLVEMFEKCKEKFSES-LSSLTDILIQADPSFSDKHILVTVGDIFGAGIETTSSVLNWILAFLVHNPEVKRKIQKEIDQYVGFSRTPSFNDRTHLLMLEATIREVLRIRPVAPLLIPHKANIDSSIGEFAIPKDTHVIINLWALHHDKNEWDQPDRFMPERFLDPTGSHLITPTPSYLPFGAGPRSCIGEALARQELFIFMALLLQRFDFDVSDDKCLVDPKVVFLIDPFKVKITVR CYP17A1_Danre PSLSPIEILIKKIFAGRPIAFADWKFHRKMVHGALCSVSIEKIICREASSMCEVLTNSAVDLGPELTRAVTNVVCALCFNSSYKRLQYSRGIVDTVFPWLQI--FPNK--IRDKLLQKKYEEHKVTYDNV-QRDLLDALLRADVGLTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQDLQKFGVVLQPKKFKVVAKVR CYP17_Fowl RSLAPLEVLLKKAFAGRPIAFASWKFQRKLVHAALSSVALEKIICREAASLCETLGDMALDMAPELTRAVTNVVCSLCFNSSYRRLEYSQGIVDTVFPWLQI--FPNR--VRDQLLQQKFTEHKEAFGDT-VRDLMDALLQVGLELTDDHLLMTVGDIFGAGVETTTTVLKWAVLYLLHYPEVQKKIQEEMDQKIGLARHPHLSDRPLLPYLEATISEGLRIRPVSPLLIPHVSLADTSIGEYSIPKGARVVINLWSVHHDEKEWDKPEEFNPGRFLDEQGQHIHSPSPSYLPFGAGIRVCLGEVLAKMELFLFLAWVLQRFTLECPQDQSLEKFGVVLQVQKFRVKARLR CYP17_Frog NSLCPFEVLLKKTFGGRPIAFANWKFHRKVVHAALSTVAIEKIISREATSLCQSLIDNPLDMAPELTRAVTNVVCALCFNTRYKRLAYSKGIVDTVFPWLQI--FPNK--IRDKLLQKKLKEHKEAFNEE-VNDLLDALLKAEVGLTDDHLLMTVGDIFVAGVETTTTVLKWTMAYLLHYPEVQTKIQEELDFKVGFGRHPVLSDRRILPYLDATISEVLRIRPVAPLLIPHVALQESSIAEYTIPQDARVVINLWSLHHDPNEWENPEEFNPERFLDENGNHVYSPSQSYLPFGAGIRVCLGEALAKMEVFLFLSWILQRFTLELPAGDDLDKFGVVLQVKKFRVTTKLR CYP21A1_Danre SGPSPLEALVKSDFAGRPISLGDWKAHRRVTHSALQTDSLHSVIEKQAQHLCQVLRGKAVDLSEDFTVASSNVITTLTFSKAYDKQECLNEIVSLWFPLLRK--FPNP--RRDELIGKHIEEFKKSEKEG--GTLTSSLLKCHTTLTDTHVHMTTVDLLIGGTETIAALLNWTVAFLLHRPEVQDKVYEELCCVLD-VRYPQYSDRHKLPYLCALISEMLRLRPVAPLAVPHRAIRNSSIAGHFIPKNTIIIPNLYGAHHDPEVWDDPYSFKPERFLEGGGGSL----RSLIPFGGGARLCLGEAVAKMEMFLFTAYLLREFKFLPASKELPEVASVVLKVKPYTVIAHPR CYP2S1_Hum PGPPPLEALGGEEFSGRGGVFFSWRQLRKFTMLALRKREGEELIQAEARCLVETFQGRPFDPSLLLAQATSNVVCSLLFGLRFSYVRAAGGTLLGVFSWFLR--PLPG--TLAAFTVRQVQQHQGNLASGPARDLVDAFLLKGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHEPNIFKHPEEFNPDRFLDADGRFRK--HEAFLPFSLGKRVCLGEGLAKAEVFLFFTTILQAFSLESPCPPSLKVSGLFNIPPAFQLQVRPT CYP2C8_Hum PGPPPIEALIDEEFSGRGGIISSWKEIRRFSLTNLRKRSIEDRVQEEAHCLVEELRASPCDPTFILGCAPCNVICSVVFQKRFDYMKRFNENFRILFPLLID--CFPG--LTRSYIREKVKEHQASLVNNP-RDFMDCFLIKKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKK--SDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLNTTTKGIVSLPPSYQICFIPV CYP2E1_Hum PGPPPIEALLDDEFSGRGGIIFNWKDIRRFSLTTLRKQGNESRIQREAHFLLEALRGQPFDPTFLIGCAPCNVIADILFRKHFDYMYLFNENFHLLFPSFLH--YLPG--EVKEYVSERVKEHHQSLPNCP-RDLTDCLLVEERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKY--SDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPDLSHIGFGCIPPRYKLCVIPR CYP2E1_Mouse PGPPPFEVLLNNEFSGRGGIIFNWKDVRRFSLSILRKQGNEARIQREAHFLVEELKGQPFDPTFLIGCAPCNVIADILFNKRFDYMSLFNENFYLLFSDYLQ--YLPG--EIRQYTLGKAKEHLKSLINCP-RDVTDCLLIEEPMYTMENISVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRAPAVRDRMNMPYMDAVVHEIQRFINLVPSNLPHEATRDTVFRGYVIPKGTVVIPTLDSLLFDNYEFPDPETFKPEHFLNENGKFKY--SDYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPDLSTIGFGSIPREFKLCVIPR CYP2F1_Hum PGPPSIEALVDEEFSGRGGIAFSWKVLRQFSIQILRKRSIEERILEEGSFLLADVRGEPFDPTFVLSRSVSNIICSVLFGSRFDYIRLINDNFQIMFPSLLD--WVPG--CLRDLIAHSVHDHQ---ASSP-RDFIQCFLTKLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKK--SPAFMPFSAGRRLCLGELLARMELFLYLTAILQSFSLQPLGAPDLTSSGLGNLPRPFQLCLRPR CYP2A6_Hum PGPPPFEALVDEEFSGRGGVVFSAKQLRRFSIATLRKRGIEERIQEEAGFLIDALRGANIDPTFFLSRTVSNVISSIVFGDRFDYLRMMLGIFQFTFSSVMK--HLPG--GLEDFIAKKVEHNQRTLPNSP-RDFIDSFLIRNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKK--SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPDVSHVGFATIPRNYTMSFLPR CYP2B6_Hum PGPPPLEALVDEAFSGRGGVIFAWKVLRRFSVTTMRKRSVEERIQEEAQCLIEELRGALMDPTFLFQSITANIICSIVFGKRFHYLNLFYQTFSLIFSGFLK--YFPG--EINAYIGHSVEKHRETLPSAP-KDLIDTYLLHHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK--TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPDLTECGVGKIPPTYQIRFLPR CYP2AA2_Danre PGPPPFEALVQEAFAGRPIIMATWKQQRRFALHTLRKKSLESRVLEESQYLIAEMLGRPMNPQHAVQNALSNIICSIVFGDRFDYLKILNESIILTAPIIKH---FPG--EVYSFVRHEVEEHRKTLPGS-PRDFIDGYLLEDSTFHEDNLITTTVDLFLAGSDSTSSSIRWGLLFLIQNPDVQERCHEEIVQVLGYDRLPCMDDRDRLPYTLATVHEIQRCGNIAPFGLFHETVQPTKLRGYNIPQGTIIMTNYTAIFSNKEHWKHPDTFNPENFLDENGQFSK--PKCFIAFGVGPRICLGDTLAKTALFLFITSLLQRIRFSLPPDADMDILSIIRYPETFSIICCSR CYP2AA1_Danre PGPPPFEAYVQDAFSGRPIVMVTWRQQRRFALHTLRKKTVEDRVLEESRYLIAEMLGKSMNPQHALQNAISNIICSIVFGDRFEYLKTLNENIMLAVPFIKH---FPG--ELLGFIRDEAKEHKQTLPDS-PRDFIDAYLLEDSTFHEENLVVSASDLFLAGTDTTETTIRWGLINLIQNPDVQERCHEEIVRVLGYDRLPSMDDRDKLPYTLATVYEIQRCANIAPN-VMHQTILPTRLHGYDIPQGTIILTNLAAIFSNKDHWKHPDAFNPENFLDENGHFSK--PESFIPFSLGPRVCLGETLARTELFLFITALLQRIRFSWPPDADMDIMGLVRSPQTFNVVCHSR CYP2AA3v2 PGPPPFETLVQDTFSGKPIAMVTWRQQRRFALHTLKKKSVEDRVLEESRYLIAEMLGKPVDPHHPIQNAVSNIICSIVFGDRFEYLKMLNETIMLAVPFIKH---FPG--DLLIFLGDEVEEHRKTLPGS-PRDFIDAYLLEDSTFHEGNLLASAGDLFMAGTDTTETTIRWGLLFLIQNPDVQERCHEEIVQVLGYDRLPSMDDRDRLPYTLATVHEIQRYGNIIPI-LIHETILPTKLQGYSIPQGTTIVTNIQAIFSSKDHWKHPDSFNPENFLED-RHFIK--PESFIMFSLGPRSCLGEILARTELFLFITSLLQRIHFSWPPDADMDIFGLVHSPQAFNVICRSR CYP2Y3_Danre PGPAPLEALVDEDFAPRAGLAISWRQLRRFTLTTLRRKQMEQWIQEESRYLLKSFESKPVDPTFFFSRTVSNVICSLVFGQRFDYLQIISKLLRFLFPQVME--RFSS--NIRTFIRNKVKEHEQRLFSD-PSDFIDCFLIRDTEFHKDNLMATVLNLFVAGTETTSTTLRYALMLLIKHPQIQEQMQREIDRVIGQNRIPTMEDRKSLPFTDAVIHEVQRYMDIVPLSLPHYAMKDITFRGYKIPKDTVIIPMLHSVLRDEGQWETPWTFNPEHFLDSNGNFKK--NPAFMPFSAGKRSCVGESLARMELFLFTVSLLQKFTFSSPNGPIDLLSSFANMPRFYELIASPR CYP2AE1_Danre PGPPPFEAFVEDIFTDRPGLIMSWRQQRRFALATLKKKTLENAILQECRFLCDSLQGLPFDPQHLVTNAVSNIICGLVFGHRFEYQTYINNILQLPFPTLMS--LLPG--KLQPFLKEEITKHQQDRPSS-PRDYIDCYLEEDAEFTEENLMFCVVDLFGAGTETTSNTLRWALAFMVKYPDVQEKVQSEIDQVIGQTRQPLMDDRTNLPYTYAVIHEIQRFANIVTFTPPRVANKDTTVGGQLIPKGVIVLPMLKPILLDKKEYSTPYDFNPDHFLDQNGKFLK--KENFIPFSIGKRMCPGEQLARMELFLFFISLMQHFTFLPVEGQSL-TTSVSSAPQPFQIRAVPR CYP2N13_Danre PSPSPLEALVTENFVDRPGLFFSWKKQRRFALSTLRKKTMELAICEESRFLLEEIDGAAFDPTILLYNAVSNIICQMVFGQRFDYLKYISKSIQLEFPAIMK--HLPG--LLKSFVHEVIVKHKAKLPSE-PRDYIDTFLIEVNGFEEPNLVACVLDLFLAGTESTSNTLCWGLIYLIMYPDVQEKVQEEIDRVIGNSREPSIADKPNMPYTEAVIHEIMRFGDVIPLNGLRVAARDTTLGECFIPKGTTVLPILHSVLFDENEWETPYKFNPGHFLDKEGKFVR--RDAFMPFSAGKRVCLGEQIARIELFLFFVSLFRKFRFSATEGENM-VIGITRTPHPFKICATAR Contig_2591 -----MEALVTENFVDRPGLFFSWRRQRRFAMATLRTSSMENRICEESRYLQDAMEGVPFDPVPLLNNAVANIICQIVFGKRFDYLNDLNELAYLEFPVLMA--HMPG--SLEIFIREEVERHKLDLSSS-PRDYIDTFLIEELGFSETNLVLCCLDLFLAGTETTSKTLQWGLIHLINDTRIQG-------EVIGQSRQPTMADRAYLPYTDAVLHEIQRIGNIVPLNGFRRAAKDMTLGGYFIPKGTSVMPILTSVLFDKTEWATPDQFNPQHFLDSEGKFVK--REAFLPFSAGKRVCLGEGLARMELFLFFVSLLQKFSFVTLDGVQT-IIGATRTPHPFQLCARHR Contig_2591-1 ------------------------------------------------------------------------------------------------FPWLMK--HLPG--TVLEFIAEEVEKHKPDLPSN-PRDYIDAFIIEDAGFDETNLAYCSMDLFLAGTETTSTTLQWALIYLIKHPEVQEKVQAEIDRVIGQSRLPTMADRANLPYTDAVIHEIQRIANIIPLNGLRLTSRDTTLGGYFIPKGTTIMPMLHSVLFDKTQWETPDTFNPGHFLDKDGKFMK--RDALLPFSAGKRVCLGEGLAKMELFLFLVGLMQKFSFYVPAGVRT-VSGATRVPHPFEVHAKVR Contig_2591-2 ------------------------------------------------------------------------------------------------FPWLMK--HLPG--TIQKFVAEEVERHKQDLPSN-PRDYIDAFIIEDTGFDETNLAYCSMDMFFAGTDTTSTTLQWALIYLIKHPEVQEKVQAEIDRVIGQSRLPTMADRTNLPYTNAVIHEIQRIGNIVPLNAPRMTSRDTTLGGYFIPKGTTIMPMLHSVLFDKTRWETPDTFNPGHFLDKDGTFMK--RDALLPFSAGKRVCLGEGLAKMELFLFLVGLLQKFSFYVPDGVRT-ITGITRVPHPFKVHAKVR CYP2X6_Danre PGPPPIEALVTQDFSGRPIVLADLKGHRRFALMTMRKQSMEERILGEISHVVDYLDGKRVDPHIMFHNVASNVISLLLFGCRFDYIQLINEISKIIFPLLRI---LPL--VIKSMNLKLIDEHKSTRPGE-PRDFIDCYLDEVSTFSEDKLLMSIMDLHFAGTDTISNTLLTAFLYLMNHPEVQVKCQQEIDDVLEGKDQVTYEDRHNMPYTLAVIHEVQRVANTVPLSVFHCTTRDTELMGYSIPKGTIIIPNLTRVLKEEGQWKFPYEFNPANFLNEQGQFEK--PEAFIPFSTGLRMCLGEGLARMELFLIFVTLLRRFQFVWPEDADYTVFGLTLTPKPYRMHIRRR CYP2X7_Danre PGPPPIEALVTQDFSGRPVVLADWKDHRRFALMTLRKQSMEERILGEISHIVDFLDGKTVDPQIMFHNIASNVINLVLFGCRFDYIQRIAENLRILFPLLRI---LPL--IIKSMNRKLIDEHKSTRPGQ-PRDFIDCYLDEVSTFSEDQLIMNIMDMSFAGTDTTSNTLLAAFLYLMNHPDVQVKCQQEIDDVLEGKDQVTYEDRHNMPYTLAVIHEVQRVANIVPLSVLHCTTRDTELMGYSIPKGTVIIPNLTVVLKEEGQWKFPHEFNPANFLNEQGQFEK--PEAFIPFSTGPRVCLGEGLARMELFLIFVTLLRRFQFVWPEDADYTVFGLTMTPKPYRMHIRRR Contig_3027-2 -------------------LVFSWREMRRFALTNLRKKACEDKISEECGHLVDVLQNEPFDSMKPLNYSVSNIICSMLYGSRFEYVDRVNTRIQLAFPWIGR--WIRN--FLKSENLSLIRRLRATLPHM-CRGVIDSFLVKDSMYNDDNLVASVTSLFSAGTETTSTTLRWGLLLMAKYPHIQDQVREEISRVIG-ARQVQTENRKDLPFTDAVIHETQRFGNIAPMAVPHRTTQDITFQGHFIKKGTTVFPLLTSVLYDESQWEKPHSFYPAHFLDKDGKFVK--RDAFMPFSAGRRVCLGEGLARMELFIFFVTLMQRFRFTPPPGVELDTMGFTLSPRPHQICAVSL CYP2K6_Danre PGPPPLEALVNEEFGDRDGIAFSWREMRRFALSTLRRKRSEELIIEEIKYVKEEFEGNPFETKLPLALAISNIIASIVFSVRFEYVGRAYENMKLTFPWLRP--IVAN--DTFKQNEELINGVMKTLPFN-PRGIVDSFLIRDSLYNSNNLYCTVNNLFGAGTDTTVTTLRWGLLLMAKYPEIQAKVQDEIERVIG-GRQPVVEDRKNLPYTDAVIHEIQRFADISPIGAPRQTTCDVHLNGYFIKKGTPVFPLLVSVLRDENEWETPDSFNPKHFLNKQGQFVK--KDAFMPFGAGRRVCIGESLARMELFLFFTSLLQYFRFTPPPGVDLDVVGFTLNPKPHQLCAVKR CYP2U1_Danre PGPPPIDAMLNETFSDRPIVFAPWRTNRRFCHSTLRRMSLEPCIHEGLAIIKTELQPSGIDLTPLISNAVSNIISLMSLGQRFHHRDLMSHGLEISFPWLYY--LPFG--DITAFLKRIIARHRATLPEN-PRDFIDMYLVEENLFSEDDLFYIIGDLFIAGTDTTTNSMLWSILYMSLYPDVQEKVQKEIDAVVGSERVPSLTDKSSLPYTEATIMEVIRMTVVVPLSIPHMASETTEFRGFTIPKGTVIIPNLWSVHRDPTVWENPDDFNPSRFLDDQGKILR--KDCFIPFGLGRRVCMGEQLAKMELFLMFTSLMQTFTFRFPEGASMHRFGLTLAPCPFTVCVKTR CYP2W1_Hum PGPPPLEALAGQELADRPGIFFSWRAARQFTVRALHREPVADKILQELKCLSGQLDGRPF-PLALLGWAPSNITFALLFGRRFDYLGLIDEVMVLLYPWLGA--L-LQ--EVRAILRTLLEARRPHVPGDPVCSYVDALIQ-EGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVK--REAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSLDARAFTMRPRAQALCAVPR Contig_1597 ------ECLYHEVFADRPLLNCKWTEHRKLACNSFRQRFFERRISEECMFFVDAIDGKPFNPKHLVTNAVSNITNLIIFGQRFTYIEIFSENVELAFPWLEY--VPFG--QVYDFLQQ-----------V-PRHYVDAYLDESSSFSKENLIYSVGELIIAGTETTTNTLRWAMLYMALYPNIQGEVHREIDSVLSNGRLPTLDDKHKMPFVEAVLHEVLRFCNIVPLGIFRATSQDANVNGYKIPKATMVITNLYSVHFDEKYWHEPGVFSPQRFLDNNGNFVK--REAFLPFSLGRRQCLGEQLARMEMFLFFTTLLQRFHLQFPPGTSVTKLGMTLQPKPYSICAVRR CYP2R1_Danre PGPPPIECLYHEVFADRP----------KLAVNCFRQRMFE-RISEECLYFLDAIDGKPFNPKHLVTNAVSNITNLIIFGQRFTYIEIFSENVELAFPWMEY--LPFG--EVYKFLLQIIRRFSQGRPQS-PQHYIDAYLDEATSFSQDNLIFSVGELIIAGTETTTNCLRWAMLYMALYPRIQEKVQMEIDSVL-NGRQPAFEDRQRMPYVEAVLHEVLRLCNIVPLGIFRATSQDAVVRGYTIPKGTMVITNLYSVHFDEKYWSDPSIFCPERFLDCNGKFIR--HEAFLPFSIGKRHCLGEQLARLEMFLFFTTLLQRFHLQFSEGFSLSKLGMTLQPQPYSICAIRR CYP2V1_Danre LGPPPFKVLNDNSFMYRPGLTFNWKQHRRFTLSTLKKRSLEFIIMEEYKFLHQSILGLPFNPHYIINNGVSNIICSMVFGRRFEYLSLISKALKLQFPRLMD--LLPG--QVRAFIKEEVDKHRADWPSS-PRDFIDCYLTEEAGFHDEGLQYAVLDLFVAGTETTSTTLLWAFVYMMKYQ-KSKKVQAEIDKVVGRYRRPSMDDRPCMPYTDAVIHEIQRMGNVVPLSVPRMTNEDTLLEGLFHSRVLQIIPNLTSVLFDQTKWKTQHSFDPQNFLNAQGKLKS--LKLLSPFSLGKRSCPGESLARMELFLFFTSFLQSFSLSAPDETSLDKCGMTLSPKPFKICFTPR CYP2J2_Hum PGPRPFEALIHQNFGNRPGLIMSWKEQRRFTLTALRKKSLEERIQEEAQHLTEAIKGQPFDPHFKINNAVSNIICSITFGERFEYLKLLDEVTYLEFPWIMK--FLPG--KLKLFVSHMIDKHRKDWPAE-TRDFIDAYLKETSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQVEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPQNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKK--REAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNESLKRMGITISPVSHRLC---- CYP2D6_Hum PGPPPGEALVTEDTADRPVFLARWREQRRFSVSTLRKKSLEQWVTEEAACLCAAFAGRPFRPNGLLDKAVSNVIASLTCGRRFEYLDLAQEGLKEEVPVLLH---IPA--AFLTQLDELLTEHRMTWPAQPPRDLTEAFLAEESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVK--PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQSHHVFAFLVSPSPYELCAVPR Contig_4427-1 ------------------------------------------------------------------------------------------------------------------------------LPNL-KKYIIKKKLS-ESGFDLRNLSFSALDLFVAGTETTTTTLYWALLFMIYYPHIQEKVQAEIDAEVG-SRMPSLQDRDELHFTNAVIHEVQRMGNILPLNVGHMTTKETTLENFTIPKGVMVIGNLDSVLHDETMWESPHTFNPGHFLDEQGKFRK--RDAFLPFSIGKRVCLGEQLARMELFLFFSGLLQRFTFSAPEGESLEDMGVVHSPKPYCLCAKLR CYP2P6_Danre PGPPPIEVYIQDNVADRPGLVAPWKQQRRFALSTLRKKSLEPSINLECHYLNEAISGRPFDPHLLLNNAISNVICVLVFGNRFDYLNNINEAMYLDHPRIMR--LLPG--KVIDFARERVKEHRVDYPSN-PRDYVDCFLAEAAGFDVENLCICTLDLFVAGTETTSTTLSWSLLYMIKYPEIQAKVQEEIDRVIGSSRQPSVSDRDNMPYTNAVIHEIQRFGNIAALNLPRAAVKDIQVGKYLIPKGTIVIGNLTSVLFDESEWETPHSFNPGHFLDAEGKFRR--RDAFLPFS-GKRVCLGEQLARMELFLFFTSLLQHFTFSSPAGVSFNKLGTTRAPKPFKLCAVSR Contig_4427-2 ----------------------------------------------------------------------------------------------------------------------------------------------LAGFNMDTLLVCTLDLLEAGTETTATTLRWALVLMMNYPEIQEKVQAEVDAVIGHSRQPIVTDRPDMPYTDAVIHEVQRFGNIVPLGFPKMASKDTTLGGYFIPKGTISTMNLSSVLFDENQWETPHKFNPEHFLDAEGRFRR--RDAFLPFSAGKRACLGEHLAKMQLFLFFASVLQRFTLKAPPGESLIVQGFTNSPDQFRMMAVPR CYP2AD2_Danre PGPPPFEALVTDSFVLRPGLTMSWRSHRRFAASHLRKKNLELGIQQECVYLCDAFKKEPFNPIFILHGAVSNTVACLTFGQRFDYLRLDNQCVQLAFPKLLD--YLPG--KITQSLKDEIIKHREDWPAN-PRDFIDNYLTEQAGFNIESLIISCLDIVEAGTETGATTLRWGLLFMIKFPEIQEKVQAEIDRVIGQSRQPCLDDRVNMPYTEAVLHEIQRFGDVVPLGFPKQAAVDTKIGNYFIPKGTSITTNLSSVLHDPNEWETPDTFNPGHFLDKNGQFRK--RDAFLPFSAGKRACVGELLARNVLFLFFTSLLQQFTLSKCPGESLEEIWFTYAPAPFRISVSVR CYP39A1_Hum PCIGPWVFLKSKLAVQNIVFLA-HEKLYIMLKGK-MLHQFTGQLTEELHEQLENLGHGTMDLNNLVRHLLYPVTVNMLFNKSLFSKEFHQYFQVYDFE---YGSQLPEWSKSKKWFLELFEKNIPDIKDN-SMTLLQATLDI--ETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKVSEDDLENLLLIKWCVLETIRLKAPGV-ITRKV-VKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLE-K---LDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLQSYLVGVPQPEGQCRIEYKQR CYP39A1_Danre PCIGPWVFFTSKQAVQEPNFFE-HPTCSAIIKGR-LTAMLSPHLCEEFNDHLESLGEGSGQLNELIKSVMYPSVMSNLLGRCNSPQEFLEKFTTYDFE---YGSQLPEWSNSKHWLLSLLRKMVIKSESD-RKTLL----QH--SISEQYLPNYGLLLLWASLANAIPVTFWAVAFILSNPTAYKIVMDQINSVLGRQGKVTLDDLQQMPYVKWCIMEAIRLRAPGA-ITRKV-VRPLKL?NYVIPPGDMLMLSPYWAHRNPKYFPDPEDFKPERWETADLE-K---LEGFVAFGGGKNQCPGRWYAIMELHMFVALILYKFEFAQLDPM--------------------- CYP8A1_Danre PLDGPWAVLSDASYAQVLP----KKRAEMHFQGA-SLTQLSNSMQNNLRLLMTPSEWKKDGLFNLCYSLLFKTGYLTVFGAENN-TQIYEEFRRFDLPKLARTTINKESAAREKLWKWLTPSGLDR-KPR-EQSWLGSYVKQE-GIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQGG-----RL-EERQKNTPVFDSVLWETLRLTAAAL-ITRDV-TQDKKIQEYHLRRGDRLCVFPFIPQMDPQIHQQPEMFQFDRFLNADRTEKARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNVPLGFGILQPAGDLEIRYRIR CYP8A1_Hum PLDGPWAVVWETAYAIFLP----KARMKLTLLHR-ELQALTEAMYTNLHAVLLGATWHEMGLLDFSYSFLLRAGYLTLYGIEALPADVFHTFRQLDLPKLARGSLSVGCSVKSRLWKLLSPARLAR-RAH-RSKWLESYLLHM-GVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAETLPQKVLDSTPVLDSVLSESLRLTAAPF-ITREV-VVDLAMREFNLRRGDRLLLFPFLPQRDPEIYTDPEVFKYNRFLNPDGSEKKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADIPEGFGLMQPEHDVPVRYRIR CYP8B1_Hum PLDGPWPILKDRQYAKKLH----HSASTKHLRGD-GLKDLNETMLDSLSFVMLTKGWHEDSLFRFCYYILFTAGYLSLFGYTK--GELFMEFRKFDFPRFVYSLLWPRGRLQHLFHKMLSVSHSQE-KEG-ISNWLGNMLQFQ-GVPSAMQDKFNFMMLWASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARAFKLGALQHTPVLDSVVEETLRLRAAPT-LLRLV-HEDYTLQEYLFRHGDILALFPYLVHMDPDIHPEPTVFKYDRFLNPNGSRKKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDLPHGFGTMQPSHDVRFRYRLH CYP8B1_Danre PLEGPWAVVKEAKFAEQLH----QASSTKHLMGD-GLVVMTQAMMYNLQNLMLHVGWQESGLFAYSYNIVFRAGYLSLFGNESPKNDLFWEFRKYDFPNLAYGVLGPSERLKRLFWSTLSVQKMRA-RDN-ISGWVSDQQQVH-GMQEFMQDRYMFLLLWASQGNTGPSAFWLLLYLMKHPEAMSAVRKEVEEILKEAGDLSRDMLLKTPILDSAVEETLRLTAAPI-LTRAV-MQDMTIQEYKIREGDRVAVFPYVVHVDPEVHPDPLTFKYDRFLNADGSRKKKLKYYSMPWGAGTTMCPGRFFATNELKQFVFLMLSYFDFELTNPNIPGGFGSMQPDRDIQFRYRPR Contig_1598 PLDGPWAFFKEEIFSRELH----EATSQKHLKGH-GLQIMTESVMSNLQNLMLHLGWKEDGLFNYCYNIVFRAGYLALYGNAISQEVLFHEICKYDFPNLVYGVLTPKYRLTALFCDGLSMERMIN-KEN-ISGWIWDMYHMQ-GMKELMIDRYMFVLLWASQGNTGPSSFWLIYYLLKHPDAMKVVRNEVLKVLKESGNITHEMLMKTPVLDSAVEETLRLVAAPL-LTRAV-LQDMTLRKFFIRKGDRIAVFPYIVHIDPEIHPDPFTFKYDRFLTPEGTQKKRVRFYTMPWGSGLSMCPGRFLATNEIKQFAFLMLLYLDFELINPDIPHGFGTMHPDREVQFRYRLR Contig_79-4 -------------------------------------------------------------------------------------EVLFHEFRKYDFPNLAYGVLTPKNRLLSFFWGTLSMERMKS-KEN-NSGWIWDMSHNE-GVQESMIDRHMFVLLWASQGNTGPSSFWLLFYLMKHPDAMEAVRNE---------NLTHEMLMKTPVLDSAVEEVLRLVAAPL-LTRSV-LQDMTLREFLIRKGDRMAVFPYIVHIDPEIHPDPFTFKYDRFLTPEGTKKKRVRYYTMPWGSGVSMCPGRFFATNELKQFVFLMLVYFDFELMNPDIPHGFGTMQPDREVQFRYRLR Contig_79-2 -----------------------------------------------------------------------------------------------------------------FFWDTLSMERIKS-KEN-ISGWIWDMSHNE-GMQESMIDRYMFVLLFVSQSNTGPSSFWLLFYLMKHPDAMEAVRNEVLKVLKESGNLTHEMLMKTPVLDSAVEETLRLVAAPL-LTRSV-LQDMTLREFLIRKGDRMAVFPYIVHTDPEIHPDPFTFKYDRFLTPEGTKKKRVRYYTMPWGSGVSMCPGRFFATNELKQFVFLMLVYFDFELMNPDIPHGFGTMQPDRESNFVTGLG Contig_79-1 ------AFAKEETFSRQLH----EATSQKHLKGH-GLQIMTESMMSNLQNLMLHLGWKEDGLFNYCYNIVFRAGYLALYGNATAQEILFHEFRKYDFPNLAYGVLTPKNRLTRFFEDSLSMKRMKN-KEN-VSGWIWDMSHME-GMKELMIDRCMFVLLWGSQGNTGPSSFWLLLYLMKHPDAMEAVRNEVLKVLKESGNLTHEMLMKTPVLDSAVEEVLRLVAAPL-LTRSV-LQDMTQREFLIRKGDRMAVFPYIVHIDPEIHPDPFTFKYDRFLTPEGTKKKRVRYYTMPWGSGVSMCPGRFFATNELKQFVFLMLVYFDFELMNPDIPHGFGTMQPDREVQFRYRLR Contig_79-3 PLDGPWAFAKEETFSRQLH----EAASQKHLKGH-GLQIMTESMMSNLQNLMLHLGWKEDGLFNYCYNIVFRAGYLALYGNATAQEILFHEFRKYDFPNLAYGVLTPKNRLTRFFEDSLSMKRMKN-KEN-VSGWIWDMSHME-GMKELMIDRYMFVLLWASQGNTGPSSFWLLLYLMKHPDAMEAVRNEVLKVLKESGNLTHEMLMKTPVLDSAVEEVLRLVAAPL-LTRSV-LQNMTLREFLIRKGDRMAVFPYIVHIDPEIHPDPFTFKYDRFLTPEGTKKKRVRYYTMPWGSGVSMCPGRFFATNELKQFVFLMLVYFDFELMNPDIPHGFGTMQPDREVQFRYRLR Ctonig_79-5 ----------------------------------------------------------------------------------------------------------------------------------------------E-GMKELMIDRYMFVLLWASQGNTGPSSFWLLFYLMKHPDAMEAVRNEVLKVLKESGNLTHEMLMKTPVLDSAVEEVLRLVAAPL-LTRSV-LQDMTLREFLIRKGDRMAVFPYIVHIDPEIHPDPFTFKYDRFLTPEGTKKKRVRYYTMPWGSGVSMCPGRFFATNELKQFVFLMLVYFDFELMNPDIPHGFGTMQPDREVQFRYRLR CYP7D1_Danre PLVGPFSVVRQKKFAINFQLSGNHSIFRQTLQGP-SLQHLTQSMLCNLQTVLERL-WLEEGVQSFTNRIMFEAGFLTLFGKEDIRPKATQDFLVFDFPLLAAGVP-IGWRAREALAEELLHDELHR-RKC-ISDLIQRRMDIM-LLDETGKARTDVCMLWASQANTLPAAFWSLYYTLKSVDAFTAARTEVNRVLL--GYLSKDQLDSMTVLESIIEEALRLSSASM-MIRVA-SDDFTLQTAAIRKGDYIALYPQLLHLDPEIYPNPTEFKYNRFLDENDQPKRRLRNFLMPFGSGASECPGRFFAVYEIKLFLALTLWHYDLQLRDPDV-VGLGIMPPSQDVLLRFRKK CYP7A1_Hum PLEGPYKVLCHKKFHFATD-GNTNDTFIKTLQGH-ALNSLTESMMENLQRIMRPVSWVTEGMYSFCYRVMFEAGYLTIFGRDLT-LNNLDNFKQFDFPALVAGLP-IHHNAREKLAESLRHENLQK-RES-ISELISLRMFLLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGCLSQAELNDLPVLDSIIKESLRLSSASL-NIRTA-KEDFTLGSYNIRKDSIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQCPPGLGILPPLNDIEFKYKFK CYP7A1_Danre PLEGPFAVIRQRKFHFDAQ-GYTHQTFLKTLQGD-ALSSLIETMMENLQGTMLQGMWQSDGIYAFCYKVMFEAGYLTLFGKELDGLNALDNFKEFDFPALIAGLP-IHYSAREKLAKTMLHENLSR-RAN-VSDLISLRMLLLSTFNELSKARTHVAILWASQANTLPATFWTLFHMIRCPAAMKAASEEVRQTFESSNVLTREQLDNMPVLDSIIKEAMRLSSASL-NVRMA-KSDFLLESYHIRKDDVIAMYPPMIHFDPEIYDDPLEFKYDRYIDEKGQEKRKLRYYYMPFGSGVTKCPGRFFAVHEIKQFLSLLLSYFEMELLDSDEPPGLGVLQPTYDVDFRYRLK CYP7B1_Hum PLIGPYLVIKNKVFSNKLH--DMHLC-YQFLQGK-SLDILLESMMQNLKQVFEPL-WDTAELYPFCSSIIFEITFTTIYGKVIVCSELRDDFLKFDFAYLVSNIP-IEKSIREKIIKCFSSEKLAK-MQG-WSEVFQSRQDVYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGHLTREQLDSLICLESSIFEALRLSSYST-TIRFV-EEDLTLGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFIE-DGKKKKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIIDDKI-GLFGIQYPDSDVLFRYKVK CYP7C1_Danre PLIGPFSVIKHKTFSDSAHFPGLQRS-YTLLQGP-ALDPLTFSMMGNLQKVLRQFLWQQAELYKFCKSAMFQSTFKTLYGHSPHLDQLREDFEKFDFPLLMARIP-IGKEIREKLIHFFYPQRMME-WTA-PCEFVQTRTALYDTLQDRDKAAHHFAMLWASVGNTIPAALWCLYHLISCLEALAAVREEITNVLGEKNAITRQQLEQMVYLESSVNESLRLYSVSM-NIRVV-QEDFCLRSINMRKDDIIALYPQSTHLDPEIYKEP-KFQFDRFVK-DGKEKQKVRYYRMPFGSGATQCPGRFFAMNELKQFVCVTLLMCEMQLLDGQA-SGLGILPPANPIPFKYKTR CYP21A2_Hum RLLNWKEAMV-------KDY---WKAHKKL-TRSALRDSMEPVVEQLTQEFCERMR--PVAIEEEFSLLTCSIICYLTFGDKIKDYKCIQEVLKTWIPF-L--RFFPNRDHIVEM-------QLRQHAGQ-WRDMMDYMLQGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGARVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGK------NSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSG--ALPHCSVILKMQPFQVRLQPR CYP21_Mouse RWLGWKEALI-------QDY---WKAHKKL-SRSALRDSMEPLIEQLTQEFCERMR--PVAIHKEFSFLTCSIISCLTFGDK--DHDCVQDLLQAWIPL-L--RFLPNRDHIVKQ-------QLKQHAGQ-WKDMIDYMLQGEERLHEGHVHMSVVDLFIGGTETTATTLSWAVAFLLHHPEIQKRLQEELDLKLGPGSQLLYRNRMQLPLLMATIAEVLRLRPVVPLALPHRATRASSISGYDIPKDMVIIPNIQGANLDEMVWELPSKFWPDRFLEPGK------NPRTPSFGCGARVCLGEPLARLELFVVLARLLQAFTLLPPP-DTLPYAGINLPIPPFQVRLQPR CYP27A1_Hum LGQ-RFQVMRQKVRNDMEPFT-TWYQLRQALNQRLLAALYTDAFNEVIDDFMTRLDNQVSDMAQLFYYFALEAICYILFEKRIGCVRSIGLMFQNSLPKWTR-PVLP-WNAIFSFGKKLIDEKLEDMGIQ-VSGYLHFLL--SGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVV--PAVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRII-EKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETELKARIVLVPNKKVGLQFLQR CYP27A1_Mouse TGT-QFQVMRQKIRDHMDIFI-AWYHLRQALKQRLLAALYTDALNEVISDFITRLDDQVPDMAHLLYHLALEAITYILFEKRIGCIRSVAIMFQNSLPKWNR-PLLP-WDNIFSFGKKLIDEKVQELGVR-VSGYLHFLL--NELLSTQETIGTFPELLLAGVDTTSNTLTWALYHLSKSPEIQEALHKEVTGVV--PFVPQHKDFAHMPLLKAVIKETLRLYPVVPTNSRIITEKETEINGFLFPKNTQFVLCHYVVSRDPSVFPEPNSFQPHRWLRKKEADNILHPFGSVPFGYGVRSCLGRRIAELEMQLMLSRLVQKYEIALAPGMEVKSRIVLVPSKKVRLHFLQR Contig_1029 -----------------------WQRIRSILNPRMLVSSYTDTINEVVTDFILKVSAVVHNLTEELYKFAFEGICSVLFETRMGCITSVGDMFMLSFPRSVW-PYLP-WDYLFKVCT--FRKKVEEI-NI-EGAYLTHLL--SEKMTLSEVLGSITELLLAGVDTTSNTISWALYHLAKEPEIQEQLYQEVSAVC--PGVPTSEDTAQMPFMKAVIRETLRLYPVVPGNARYMVDNEIIVGDHLFPKKTLFHLCHFAVSYDERIFPSPHSFLPHRWLRGSEEK-RLHPFGSVPFGFGTRACLGRRVAELEMYLLLSRVRR------------------------------- CYP27A3_Danre PSF-TSQVLRQRIRTDMPPLT-EWQRIRSILNPRMLVSNYTNAINGVVSDFIEKMAVMVYDVAGELYKFAFEGISSVLFETRMGCIFSVGEMFRLSFPKFLW-PYMP-WDHLFKVADELVQQKMTEI-PV-EGEYLTHLL--SEQMSFTEVLGSITELLLAGVDTVSITISWALYHLAREPEIQQKLHEEVVSVC--PGTPSSDDITRMPLLKAIVRETLRLYPVVPANARVVAQNEIVVGDHLFPKQTLFHLCHFAVSYDETVFPDPFAFLPQRWIREQKQ--SQHPFGSVPFGFGIRACLGRRVAELEMYLLLSRLIKRYEVRPDPSGTVKTRTLLVPATSIDLQFIDR CYP27C1_Hum PRT-ANQVLRAAQRANMELIS-AWLKMRSVLRQRILVAIYSGEVNQVIADLIKRIYETVTNVNDLFFKYSMEGVATILYESRLGCIEALELMFSMFIPRWLR-PFIPKWDGLFKFSQIHVDNKLRDIRRV-SGGLLTYLF--SQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNL--GEVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVT-QEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDL--RVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTAVHTHGLLTPGGPIHVRFVNR CYP27C1_Danre PST-ANQVLRSAQRGNMELIS-AWLKMRSVLRQLIMVAVFSSDVTDVVADLVKRVKQTVLNINDLFFKYAMEGVATILYETRLGCITALHLMFSSFIPKWLR-PIIPKWDGLFKFS-IHVDKRLSEIEEI-KGGLLTHML--TREMNLEEIYANMTEMLLAGVDTTSFTLSWSTYLLARHPTIQQQIFEEVDRVL--GGVPTGEDVPYLPLIRGLVKETLRLFPVLPGNGRVT-HDDLIVGGYLIPKGTQLALCHYSTSMDEENFPRPEEFRPDRWIRKDAS--RVDNFGSIPFGYGIRSCVGRRIAELEMHLALTQLLQNFHIEVSPQTEVHTHGLLCPGASINLRFTDR CYP27B1_Hum PST-SFELLRQPERCSFSLLT-AWQRLRSLLAPLLLAARYAGTLNNVVCDLVRRLRALVRDVAGEFYKFGLEGIAAVLLGSRLGCIRAVGSVFVSTMPHWLR-HLVPGWDQMFAFAQRHVERREAEADLE-SGAHLTHFL--REELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVP-DKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGP---TPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAPVRTRTVLVPERSINLQFLDR CYP27B1_Frog PST-SFQVLRQKIRSDLSLLT-AWQQFRSILGKHMLVEAYSDVLNDVVGDLIKKINNVVKDIAKEFYMFGLEGISSVLFESRIGCIQSINTMFVMTMPKFLH-KIFRKWDYMFAFAKGHIDKRMKDVEKV-EGKYLTYYL--QEKIPMKSIYGNVTELLLAGVDTISSTLSWSLYELAQHPDIQSAVYSEVEEIL-QG-IPSPSDVARMPLLKAVVKEVLRLYPVIPGNARVVADRDIQVGDYIIPKKTLITLCHYATSRDENVFSNPNEFQPDRWLKKED---THHPYASLPFGFGKRSCIGRRIAELEVYLALARILSHFEVKPEQPGLVMTRTLLVPEKEINLQFLER Contig_2 --------------------------------------------------------------------------------------------------------------------KGHIDQRLAAEEKV-EGRYLTFFL--QTGLPMKTVYSNVTELLLAGVDTISSTLSWTLYELSRHPEVQSRLREEVLKVL--GDIPEAADVAQMSLLKATVKEVLRLYPVIPANARVITERDIHVGGYIIPKKTLITLCHFATSRDPAVFSSPDEFLPQRWLNRDH---THHPYATVPFGVGKRSCIGRRIAELELYLAIARVS-------------------------------- CYP27B1_Danre PSP-RFQVLRQQMRSELSLLT-SWQCVRSLLSKHMLVEAYDGALNAVVSDLLQKLKRIVSDISAEFYRFGLEGISSVLFESRIGCIQSINTMFVMTMPQWLH-RLLPKWDVMFEFAKGHIDQRLQQEEQL-EGRYLTYFL--QAGLPLTSVYSNVTELLLAGVDTISSTLSWSLYELSRHPDVQTALR?EVLSVM-KGRVPQASDVAAMPLLKAVVKEILRLYPVIPANARVIN-KDIEVGGYVIPKNTLITLCHYATSRDPQQFRDPDSFRPQRWGDRSD---RSHPYATVPFGVGKRSCIGRRIAELEVYLALSRILMHFTVEPARQDTVHTRTLLVPERQIDLRFTER CYP24A1_Danre PTNPGSALYRKSERLEIKLLI-L-------------------------ADLIK---GKMDDLYFELNKWSFETICYVIYDKRFGLITAVKTMMSTFPVELHK-TLNTKWDRIFSTAKHYIDKNLQKQ-----DDFLSDIF--NGNLTKKELYAATTELQVGGVETTANSMLWVIFNLSRNPCAQGKLLKEIQDVV--PATPRAEHIKNMPYLKACLKESMRVSPSVPFTSRTL-DKDTVLGDYTLPKGTVLMLNSQAIGVSEEYFDNGRQFRPERWLEEKS---SINPFAHVPFGVGKRMCIGRRLAELQIQLGLCWILRDYKIVATD-LPVDHSGTLVPSRELPVAFVPR CYP24_Hum PTSPASALYRT-QRLEIKLLI-LWQRVRSAFQKKLMVMKLDNKINEVLADFMGRIDGHVEDLYSELNKWSFESICLVLYEKRFGLIMAIKTMMSTFPVELHK-SLNTKWDTIFKSVKACIDNRLEKY-----ADFLCDIY--QNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL--PERPREEDLRNMPYLKACLKESMRLTPGVPFTTRTL-DKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKE---KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATD-NPVEHSGTLVPSRELPIAFCQR CYP24A1_Mouse PTNPGSALYRTAQRLEIKLMI-LWQRVRSAFQKKLMIMKLDKKINEVLADFMGQIDGRIQDLYSELNKWSFESICLVLYEKRFGLIAAIKTMMSTFPVELHK-RLNTKWDTIFKSVKPCIDHRLERY-----ADFLCDIY--QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQRLLREIQSVL--PDTPRAEDVRNMPYLKACLKESMRLTPSVPFTTRTL-DKPTVLGEYTLPKGTVLTLNTQVLGSSEDNFEDADKFRPERWLEKEK---KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIIQKYNIVATD-SPVEHLGILVPSRELPIAFCPR CYP11B1_Hum RPGRLRKLQQVLHRMSLEVFL-LWRFNRLRLNPEVLVQRFLPMVDAVARDFSQALKSLTLDVQPSIFHYTIEASNLALFGERLGLLHALEVMFKSTPRSLSR-WTSPKWDCIFQYGDNCIQKIYQEL-QQ-YTSIVAELL--NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAA--ASEHPQKATTELPLLRAALKETLRLYPVGLFLERVA-SSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG---SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLT-QDIKYSFILRPSMCPLLTFRAI CYP11B1_Danre TGSGMNELFRSLRRMTLQVFL-KWRADRLLLNREVMVHRFLPLLDEVAQDFCRSLRTLTLDPSPDLFRFALEASCHVLYGERIGLISAVERMLATTPPRLLL-RLRASWDDIFSHAEQRIQRSYQRLDCS-FPGVLGKLM--AGQLSLELIQIHITELMAGGVDTTAVPLQFALFELARNPDVQECVRAQVLSSW--RQGDPLNALQGAPLLKGTLKETLRLYPVGITVQRYP-VRDIVLQNYHVPAGTLVQVCLYPLGRSAEVFSRPECFDPSRWSADADA--SAGGFRSLAFGFGSRQCVGRRIAENEMQLLLMHILRTFKLTVSS-TELSYTLILQPECPPRITFSTL CYP11A1_Hum PGDGLNLLFKSPERFLIPVLL-KWKKDRVALNQEVMTKNFLPLLDAVSRDFVSVLHNYSGDISDDLFRFAFESITNVIFGERQGMIDAIYQMFHTSPPDLFR-LFRTKWDVIFSKADIYTQNFYWELHHD-YRGMLYRLL--DSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR--HQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL-VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDK---NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQH-LDVGFNLILMPEKPISFTFWPF CYP11A1_Mouse PGDGLNILFSCPERFLVPVLF-KWKKDRIVLNQEVMIKNFVPLLEGVAQDFIKVLHNFSGVISDDLFRFSFESISSVIFGERMGMINAVYQMFHTSPPDFFR-LLRTKWDVIFNKADEYTQNFYWDL-SQ-YPGVLYSLL--GNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAAR--RQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYT-VNDLVLRNYKIPAKTLVQVASFAMGRDPGFFPNPNKFDPTRWLEKSQ---NTTHFRYLGFGWGVRQCLGRRIAELEMTILLINLLENFRIEVQN-LDVGFSLILMPENPILFNFQPL CYP11A1_Danre RWRSLSILFKAHNRINVDVLL-KWKTDRMILNKELLQGTFVPLLEEVGQDFVARVNQWTTDLTHDLFKFSLESVSAVLYGERLGLIDCVSVMFKTTPPGLLR-SIGSNWDGIFNQADRYIQNIFKQWNGK-YPGVLAILL--QDKLSIEDIKASVTELMAGGVDSVTFTLLWTLYELARQPDLQDELRAEISAAR--IAGDMVQMVKMIPLLKAALKETLRLHPVAMSLPRFI-TEDTVIQNYHIPAGTLVQLGVYAMGRDHQFFPKPEQYCPSRWISSK-----RQYFKSLGFGFGPRQCLGRRIAETEMQIFLIHMLENFRIEKQK-QEVRFELLLMPEKPIMLTIKPL CYP11A1_Fowl EWRGLNTLFKSMERFSVPVLL-KWRSDRLTLNKEVLVDSFVPLLDQVSQDFLRRARRWTADFSHELFRFALESVCHVLYGERLGLIDAVTLMFHTTPPALLR-HLNTKWDAIFTQADKCIQNVYRDITEE-HTGILFSLL--QDKLPLDDIKASVTEMMAGGVDTTSMTLQWAMLELARSPGIQERLRAEVLAAK--QEGDRVKMLKSIRLLKAAIKETLRLHPVAVTLQRYT-TQEVILQDYRIPPKTLVQVGLYAMGRDPEVFPKPEQFNPERWLVMG-----SKHFKGLSFGFGPRQCLGRRIAELEMQLFLMHILENFKIETKR-AEVGFDLILVPEKPIYLRLRPL CYP20A1_Hum T--TEKQHINPTTMLKS-SGGGSENHMRKKLYEN-GLKSNFALLLKLSEELLDKWLQHV-PLSQHMLGFAMKSVTQMVMGSTFEDQKNHGTVWSEILDGS----L---LMQLESVLRNIIKERKGR-NFS-QHIFIDSL---QGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNG-PVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQ-DIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVM-K---TFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQETK--LVTSSREEAWITVSKR CYP20A1_Danre N--TEKQHINPTTMLKS-SGSGVESMMRKKVYEG-ALENNFPLLLQQVEELVDKWAQHT-PLCAHFLGLAMKAVTQLAMGSRFRDRKNHEAIWSEILDGS----L---LAEMESVLKSVAKQRPGQ-GSS-Q-SFVNYL---QANLTERQVMEDGMVFTLAGCVITANLCIWAVHFLSVSEAVQDRLYHELVEVLGDE-LVSLEKIPQLRYCQQVLNETVRTAKLTPVAARLQ-EVEGKVDQHVIPKETLVIYALGVVLQDADTWSLPYRFNPDRFAEESVM-K---SFSLLGFS-GSQACPELRFAYTVATVLLSTLVRRLRMHRVDGQEAR--LVTTPKDDTWITVSKR CYP19_Hum G---YCHIMKHY--SSRFIIFNNWKTTRPFFMKA-LLVRMVTVCAESLKTHLDRLESGYVDVLTLLRRVMLDTSNTLFLRIPLDEIQGYFDAWQALFFKI-S-W----VKDLKDAIEVLIAEKRCRILEE-CMDFATELILARGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD-IKIDDIQKLKVMENFIYESMRYQPVVDLVMRKA-LEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENFAKNVPY-R-----YFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQESIIHDPDETKNMLEMIFTPR Contig_1563 Y---FLHILRSY--IARFIIFNSWKKARSFFAK---LQRTVSVCVESTTKHLDNLHSGQVDTLNLLRAIVVNISNKLFLGVPFNEIHNYFETWQTVFFMI-G-W----GQELQDVIQELLEVKKKMILDD-DRDFATELIFAHGELSSENVRQCVLEMVIAAPDTLSITLFFMLLLLKQNPAVEESIVEEMKAVLGDGG-AENLKHQDLNLLEKFINESMRFHPVVDFTMRKA-LEDDTIDDIKIRKGTNIILNIGLMHKT-EYFTHPNEFTLDNFDKTVPN-R-----YFQPFGCGPRSCVGKHIAMVMMKAILVTLLSRYTVCPLQGRSSITNDPVEDEDSLAMRFIPR Contig_1685 -------------------------------------------------------------------------------------IHLYFETWQAVYFKL-H-W----AQELKDAIEELVEQKRRAMLD--HINFTAKLIFAHGELSADDVRQCVLEMVIAAPDTLSLTLLFMLLLLKEHPLVELQLLREIDTVVGERRAVQNSDLPRLQVMESFINESLRFHPVVDFSMRRA-LADDVIDGYSVPKGTNIIVNTGHMHRT-EFFPKPNEFSLENFEKNTPR-R-----YFQPFGSGPRNCVGKYMAMVMMKAILVTLLSQYSVCPHDLVEMLTNDPVEKDEPLTMDFLPR CYP19A1_Danre S---FFHVLRKY--TSRFIIFNSWKKVRAFYAKA-LLQRTMEICTTSTNSHLDDLSQGQLDILNLLRCIVVDVSNRLFLGVPLNEIHKYFDTWQTVYFRL-D-W----AQELQDAITALIEQKKVQLLD--HLDFTAELIFAHGELSAENVRQCVLEMVIAAPDTLSISLFFMLLLLKQNPDVELKILQEMDSVLAG-QSLQHSHLSKLQILESFINESLRFHPVVDFTMRRA-LDDDVIEGYNVKKGTNIILNVGRMHRS-EFFSKPNQFSLDNFQKNVPS-R-----FFQPFGSGPRSCVGKHIAMVMMKSILVALLSRFSVCPMKACENITNNPVEEPSSLSVQLILR CYP46A1_Danre P--DFLTIMMSYPFVYRRLITAVWYRQRRIMDPA-FLRSLISTFDEMSERLMDKLEKTPAVMHDLVNCVTLDVICKVAFGVDLNFQNAVELCLKGMIPKN---WK---TELLRKTGEKWIQNRKTAV------DILTQILKSQNVTSTEDFEQMLDNFVMAGQETTANQLSFAIMELGRNPEIYKRAKAEVDEVLGTKREISNEDLGKLTYLSQVLKETLRLYPTAPGTNRWL-HEDMVINGIKIPGGCSVMFSSYVSQRLEKFFKDPLKFDPERFDVNAP----KPYYTYYPLALGPRTCIGQVFSQMEAKLVLAKLLQRFEFSLVPGQSFDDNGTLRPKSGVICNIKQC CYP46_Hum P--PFLKFLMSYSKMYRALVSECWHKQRRVIDLA-FLVSLMETFNEKAEQLVEILEQTPVSMQDMLTYTAMDILAKAAFGMETSMSQAVKLMLEGILPGK---RK---IRFLRQVGRDWVQRRREAL------DILTQILKA----GAQDDEGLLDNFVIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLL-EEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAP----KPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGEQATLKPLDPVLCTLRPR CYP46_Mouse P--PFLKFLMSYSKMYRALVSECWYKQRKVMDLA-FLVSLMETFNEKAEQLVEILEQTPVSMQDMLTCATIDILAKAAFGMETSMSQAVKVMLEGIMPGK---RK---IRLLRQVGKDWVQRRREAL------DILTQILKA----GAQDDEVLLDNFVIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRHLDYEDLGRLQYLSQVLKESLRLYPPAWGTFRLL-EEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAP----KPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVPGQRFGEQATLKPLDPVLCTLRPR CYP46_Rat P--PFLKFLMSYSKMYRALVSECWYKQRRVMDLA-FLVSLMGTFNEKAEQLMEILEQTPVSMQDMLTCATIDILAKAAFGMETSMSQAVKVMLEGIMPGK---RK---IRLLRQVGKDWVQRRREAL------DILTQILKA----GAQDDEVLLDNFVIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRHLDYEDLGRLQYLSQVLKESLRLYPPAWGTFRLL-EEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAP----KPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGEQATLKPLDPVLCTLRPR CYP4V2_Hum A--APLGILTSQSSMYKFLLT-SWRSRRKMLTPT-FLEDFLDIMNEQANILVKKLEQEAFNCFFYITLCALDIICETAMGKNIGAVRAVYRMSEMIWYLM---FK---LQILHTFTNSVIAERANEMKNK-RRAFLDLLLSVGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVK--SDPATVEDLKKLRYLECVIKETLRLFPSVPLFARSV-SEDYFTAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQ-G-RHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKRELGGQLILRPSNGIWIKLKRR CYP4V7_Danre A--APIVVLSNHSYSYRFLLT-SWRNRRKMLTPT-FLSDFLEVMNEQTDILIQKMQGEPFNCFNFITLCALDIICETAMGKKIYAVQSVYKMSDIIIYNK---LK---LKILHSFTANVIRERAEFMGRK-RQAFLDMLLKTGQKLSHEDIQEEVDTFMFEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFGSSEHVGVEDLKKLRYLECVIKESLRIFPSVPLFARSI-CEACHIDGFKVPKGVNAVIIPYALHRDPRYFPEPEEFQPERFMPENSK-G-RHPYAYIPFSAGPRNCIGQRFAMMEEKVVLATILRHFDVEACQSRELRGELILRPEKGIWIKLQRR Contig_2650-1 ----------------------------------------------------------------------------------------------------------------------NIS------GKK-RRAFLDMLLKTGNSMSHQDIQEEVDTFMFEGHDTTAAAMNWALHLLGSHPEVQRKVHQELDEVFE---PINTEDLKKLRYLECVIKEGLRLFPSVPFFARTI-CQDTTIKGYKVPKGSNVIIFTYVLHRDPRFFPDPDEFRPERFLPENSV-G-RPAYAYIPFSAGLRNCIGQRFALMEEKVVLASVLRSFTVEACQKRELQGELILRPEKGIWIKLEKR Contig_2650-2 ------------------------------VDPT-FLADFLEVMNEQAEILVEKLHKGVFNCFSHVTLCALDIICGQYSTQN---PNMSSVMSDIVVYYS---IG---LKVLHSFTYKNIS------EKK-RRAFLDMLLKTGNSMSHQDIQEEVDTFIPQGHDTTAAAMNWALHLLGSHPEVQRKVHQELDEVFE---PINTEDLKKLRYLECVIKEGLRLYPSVPFFARTI-CQDTTIRGFKVPKDSNVIIVTYALHRDPKYFPEPEAFRPERFLPENSV-G-RPAYAYVPFSAGLRNCIGQRFALMEEKVVLASILRNFTVEACQKRDLQGELILRPENGILIKVEKR CYP4F2_Hum P--RWFPVLFAAKFFYSFLLL-SWSRHRRMLTPA-FLKPYMKIFNESVNIMHAKWQSACLDMFEHISLMTLDSLQKCVFSFDSHCIAAILELSALVLYYL---TP---CRLVHDFTDAVIQERRRTLKSK-TLDFIDVLLLSGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHV-TQDIVPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIK-E-RSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLAFRVLPDHTE-PRPELVLRAEGGLWLRVEPL CYP4F43_Danre P--RWISLLTASRIFYGFLLL-QWSRHRRLLTPA-FLKKYVHIFNQSTNIMHDEWREHSVDMFEQISSLTLDSLLKCTFSCDTHSISAILDLSRLLLYWR---SA---CAVVHQFTADIVQERRTQLKRK-NTDLIDLLLLAGEALTNEEIKAHADMFMFAGHDTTASALSWIFYNLAMNQDYQERCRAEVRDLLADRDTIGWEDLSQLTFTTMCIKESLRLHSPVLALTRYY-SQNMKPGDCVIPHGCLCLISIYGVHRNPQVWPDPLVFDPTRFDPHNSD-S-RSPHAFIPFSAGPRNCIGQNFAMAEMKVVVALTLARFKILPGPKP-VRYQLVLRAEGGMILHFQEL CYP4T8_Danre P--AWLTILTT-DYAYKFLLV-SWFRHRRLLTPG-FLKPYVKLISDSTKVMLDKWEEESFELFKHVSLMTLDSIMKCAFSCNSNCIQAVFDLCHLVIFHL---SP---ASIAHNHTAEVIRKRKEVLNRR-YLDFLDILLSAQQGLSDEDIRAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCRQEIQQALDGKDTLEWEDLNKIPYTTMCIKESLRLHPPVPGISRKL-TKPLTFDGRTVPEGCTIGVSIYGIHMNSTVWENPYKFDPLRFLPENAA-N-RSPHAFVPFSAGPRFVTRSV---------------------------------------------- CYP4Z1_Hum P--AWFILLKR-AVSHKILVT-LWKKHRQIVKPG-FLKIFITMMSESVRMMLNKWENSRLELFQHVSLMTLDSIMKCAFSHQGSILKAVFNLSKISVFKF---SS---NQELHQFTEKVIQDRKESLKRR--WDFLDILLSATKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLL-DKPITPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSE-K-IHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQRQVVLKSKNGIHVFAKKV CYP4X1_Hum P--TWFTLLSR-QYLQKFLAA-LWFQHRRLLTPG-FLKAYIEVMAHSVKMMLDKWEDTSVEVYEHINSMSLDIIMKCAFSKETNCAKAIFELSKIIIFKL---SP---SRVLNQYTDTIIQERKKSLKRK-YQDFLDIVLSAGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDL-SKPLTPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSD-Q-RHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTNHFILKPKNGMYLHLKKL CYP4X1_Mouse P--AWLIFLSR-QYLHQLLLN-LWFQHRCLLTPA-FLKPCVDTMAHSVKVMLDKWEETTIEVFEHINLMTLDIIMKCAFGQETNCVKATFELGEIIIFKL---SP---GKVIHQYTEKIIQDRKKILT---SQIFLDIVLSAERAFSDADLRAEVNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDGSSITWEQLDEMSYTTMCIKETLRLIPPVPSISREL-SKPLTPDGHSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPLRFTKENSD-Q-RHPCAFLPFSSGPRNCIGQQFAMLELKVAIALILLHFQVAPDLTRPPASHTVLRPKHGIYLHLKKL CYP4A11_Hum P--SWLVILGR-HGSYRFLLL-LWFQHRRMLTPA-FLKPYVGLMADSVRVMLDKWEDSPLEVFQHVSLMTLDTIMKCAFSHQGSIIQAISDLNNLVIYSL---TS---CQLAHQHTDQVIQLRKAQLRKR-HLDFLDILLLAGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGREL-STPVTPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSA----QHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIARLVLKSKNGIHLRLRRL CYP4B1_Hum P--TWLAVYSR-PDVYDFLLV-LWLQHRKLLTPG-FLKPYVAVFTESTRIMLDKWEGKSFDIFCDVGHMALNTLMKCTFGRGDT-YLAVSDLTLLMIYWL---TP---CQVAHDHTDQVIRERKAALNRR-HLDFLDILLGADIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQL-SKPVTVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENAS-K-RHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIPQLVLRSKNGFHLHLKPL CYP26A1_Hum PGTGPFRILLGR--LVSVCLSNLHKQRKKVIMRA-FLECYVPVITEEVGSSLEQWL-------RGLLVYMFRIAMRILLGCEPQLVEAFEEMTRNL-PFS--------RNLIHARIEQNIRAKICGLGQG-CKDALQLLIEHGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVA-LKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPE-D-ASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLN-GTMKTSPTVYPVDNLPARFTHF CYP26A1_Danre PGTGPFQILLGK--LVSVTLSNVHKNKKKAIMRA-FLEHYIPVIQQEVKSAIQEWL-------SCVLVYMFRIAMRILLGFEPEQVEAFEEMIKNL-PFS--------RNFIHSKIEENIRKKIQDDEQK-YKDALQLLIENDEPFSLQAMKEAATELLFGGHETTASTATSLVMFLGLNTEVVQKVREEVQEKVEMGMGLSMELLDQLKYTGCVIKETLRINPPVPGGFRVA-LKTFELNGYQIPKGWNVIYSICDTHDVADVFPNKEEFQPERFMSKGLE-D-GSRFNYIPFGGGSRMCVGKEFAKVLLKIFLVELTQHCNWILSN-GTMKTGPTIYPVDNLPTKFTSY CYP26C1_Hum KGSGPFTILLGR--LVRSTLLGAHRRRRKVLARV-FLERYVPRLQGALRHEVRSWCVSV---------YTFRMAARILLGLRLDEARTFEQLVENL-PFS--------RDQLHRHLEGAISEKLHEDAAE-PGDALDLIIHSGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRADLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTA-LRTFELDGYQIPKGWSVMYSIRDTHETAAVYRSPEGFDPERFGAARED-SASSRLHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWELATPAAMQTVPIVHPVDGLRLFFHPL CYP26C1_Danre QGSGPLKILLGT--VVCTTLVNSHKRKRKVLAKV-FQ*APFIRLQDVVEFDIAKWCVEV---------TTFRITVGVVLGMHLKDSKALEQLMNNL-PVS--------REILHSAMEKIIEEKLKKQASD-YCDAFDYMLSSDYELTMQELKSPAVELIFAAHSTTASASTSLIMQLLRHPDVSERARAELESEGLITDYLSLEKLSQLSYLDCVVKEVLRFLPPVSGGYRTV-LQTFELNGYQIPKGWSVMYSIRDTHETAEAYQNPEFFDPDRFCVGREE-S-SERFSYVPFGGGVRRCIGRELALIVLKTLAVELLATADCTLATQTRMQTVPIVHPVNGLHVFFNYR CYP26B1_Hum KGSGPLKILMGH--LVSTTVSNSHRNKRKVFSKI-FLESYLPKIQLVIQDTLRAWSINV---------YTFRMAIRVLLGFSIPEFEVYQQFVDNV-PFS--------RQILQKGLEKAIREKLQCTGKD-YLDALDLLIESGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTV-LQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSE-D-DGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTRITLVPVLHPVDGLSVKFFG- Contig_1854 -----------------------------VFAKV-FLQSYLPKIQQVIQESLRVWSSTVMNVCKCVCVSSFTMAVRVLLGFRVSEFSTFQDFVDNL-PFS--------RDTLQRSIEKAILEKPLS-SKD-YSDALDVLMESGTELSMQELKESTIELIFAAFATTASASTSLIMQLLRHPQVLERLRDELRARGLLQNELRLDTVVSLRYLDCVIKEVLRLFTPVSGAYRTA-VQTFELDGVQIPKGWSVMYSIRDTHDTSSVFKDVDAFDPDRFSQERGE-D-EGRFHYLPFGGGVRSCLGKQLATLFLRLLAIELASTSRFELATRSRMVTVPVVHPTDGLKVKFYG- CYP26B1_Danre KGSGPIKVLMGS--LVTVSLANSHRKRRKIFAKV-FLESYLPKIQQVIQETLRVWSINV---------YSFNMAVRVLLGFRIPEFSTFQEFVENV-PFS--------RDSLQKSIEKAIREKPLHTGKD-YTDALDVLLESNTELTMQELKESTIELIFAAFATTASASTSLVMQLLRHPAVLEKLREELRSCGLLHDELRLDSIISLKYLDCVIKEVLRLFAPVSGGYRIA-TQTFELDGVQVPKGWSVMYSIRDTHDTSAVFKDVEAFDPDRFSPERSE-D-EGRFHYLPFGGGVRSCLGKQLATLFLKLLAVELAGGSRFELSTRTRMISVPVVHPTDGLRVKFFG- Contig_1333 ------DLNAEY--SKLTIPNA----QKKLLKTG-LFRDHVRIIEAETIEYFQRWGG----VENLFEALSELIILTASSCLHGKEVAQLYADLDGG--GWLP-LP---KNIFFKVIQKRRQ------AEK-VDDFLQTLVDAGRPLTDDEIAGMLIGLLLAGQHTSSTTSSWMGFFLAQDKSLQDRCYTEQKAVCGED-PLDFDQ--------RCLKETLRLRPPIMQHTLSC-IILQTAAGYTIPVGHQVCVSPTVNHRLHDTWVERLEFNPERYLTDSPA-A-GEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRMYEFELVDGYTINT-MIHTPHNPV-IRYKRR CYP51_Hum ---PPFDLNAEY--SRLTVPNPVFLEQKKMLKSG-LFKQHVSIIEKETKEYFESWGG----EKNVFEALSELIILTASHCLHGKEVAQLYADLDGG--GWLP-LP---KDIFYKAIQKRRQ------QEK-IDDILQTLLDAGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGEN-PLTYDQLKDLNLLDRCIKETLRLRPPIM-----------TVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPA-S-GEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYTVNT-MIHTPENPV-IRYKRR CYP51A1_Danre ---SPFDLNAEY--ARLTVPNPLFLEQKKMLKTG-LFKQHVEIIEEETKDYFRRWGG----ERNLFDALSELIILTASRCLHGCEVAQLYADLDGG--GWLP-LP---KKIFYNVIKKRRE------TEK-HDDILQTLIDAGRPLSDDEIAGMLIGLLLAGQHTSSTTSAWMGFFLARDRALQERCYSEQKSVCGEE-PLHYDQLKDLSLLDRCLKETLRLRPPIM-----------KVGEYTIPPGHQVCVSPTVNHRLQDTWAERLDFDPDRYLHDNPA-A-GEKFAYIPFGAGRHRCIGENFAYVQIKTIWSTLLRMFDFELVDGHPVNT-MIHTPHNPI-IRYTRR CYP3C1_Danre ---PPFTILVKY--STFTGITLVWRRIRSSLSPY-FLKEIFPIAMTHADRFIKNMENLPLKIKDVVAPYSLDVVASSSFSVDFDSVTSIKSFFNINCPSAAN-LL---TDFYYKALRKIKDEH----SNG-RVDFLKLMIQNVKGLTDHEILSQSFIFILGGYETTSTTLSYLLYNLATNPDCLEKLVEEIDKNFPLD-PITYDALMRMDYLEMAIHESMRVFPAGPRLERVC-KKTVEINGITIPKNTLVGIPLYVLSRDPDLWESPNEFKPERFSPESKT-E-INQCAFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKYTVETCKETPVQF--FFQPKVPITLKLIPR CYP3_Rat ---PPFTVLVKY--STFTAISISWKRIRALLSPT-FLKEMFPIINQYTDMLVRNMRGKPTSMKDIFGAYSMDVITATSFGVNVDSVEKIKKLLKFDFPFLTP-LF---IDFFKTSVERMKENR----EKQ-RMDFLQLMINSHKALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNK-HATYDTLLQMEYLDMVVNETLRLYPIAGRLERVC-KTDVEINGVFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQD-N-INPYMYLPFGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKETPLKKQGLLQPEKPLLLKVVSR CYP3A4_Hum ---PPFTVLVKY--SVFTAISIAWKRLRSLLSPT-FLKEMVPIIAQYGDVLVRNLRGKPVTLKDVFGAYSMDVITSTSFGVNIDSVENTKKLLRFDFPFLIP-IL---TNFLRKSVKRMKESR----QKH-RVDFLQLMIDSHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNK-PPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVC-KKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKD-N-IDPYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETPLKLGGLLQPEKPVVLKVESR CYP3A7_Hum ---PPFTVLVKY--SVFTAISIAWKRIRSLLSPT-FLKEMVPIIAQYGDVLVRNLRGKPVTLKHVFGAYSMDVITSTSFGVSIDSVENTKKLLRFNFPFLTP-IL---ISFLTKSVKQIKEGR----QKH-RVDFLQLMIDSHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNK-PPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVC-KKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKD-N-IDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETPLKFGGLLLTEKPIVLKAESR Contig_3024 -------------------------------------------------------------------------------------------------------------------------------------------------LSDHEILSQAMIFLFAGYETTSSSLCFLAYNLAVNPEVMEKLQAEIDSTFPNK-SAQYQEVMQMEYLDCVVNESLRLYPIA-RLERVA-KASVEINGLLIPKDMVVMVPTWPLHRDPDIWPEPEAFKPERFSKENKD-N-IDPYTYMPFGIGPRNCIGMRFALVMMKLAIVEILQKYSFSVCKET--------------------- CYP3A65_Danre ---TPFTVLIKY--SLFTAVSIAWRRIRSVLSPS-FLKEMFGIMKKHSHILVDSMGGESADIKEFFGAYSMDVVTSTAFSVDIDSVTNIKKMLKFDFPFMAP-VL---TDFFYAALQKIKSDRDTKTTKK-RVDFLQLMVDSEKGLSDHEILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETFPNQ-PVDYETLMSMDYLDAALSESLRLYPVAARLERVC-KKTVEINGLLIPKDLVVMVPTYALHRDPDYWSEPESFKPERFTKGNKE-S-IDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETPLEFNGLLSPKDPIKLKLQPR CYP5A1_Hum ---PPFQVLVEF--SNFTSVLFLWEEVRGALMSA-FLNEMVPLISQACDLLLAHLKGDAFDIQRCYCNYTTDVVASVPFGTPVDSVKHCKRFFEFCFPSIMV-PL---NGFFNKLIRNVIALRDQQ-EER-RRDFLQMVLDAARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKH-APEFCSLEGLPYLDMVIAETLRMYPPAFRFTREA-AQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQ-Q-HRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETPLQSKSALGPKNGVYIKIVSR CYP5A1_Danre ---PPFQVMVKF--NKFPSLIMLWKRVRSILTPT-FMKEMVPLINTATETLLRNLKENSFNIHKCFGCFTMDVIASVAFGTQVDSVHQASKFFAFSFPFLLR-PL---NSFFTQCIQKMIKQRDDL-EQR-RKDFLQLMLDVKRMMTEDEIVGQSFIFLVAGYETSSNTLAFTCYLLAVHPECQKKLQEEVDEFFSRH-MVDYANVQELKYLDMVICESLRLYPPAFRVARDV-EEDTVLNGQFLPKGASLEIPTGFLHYDPEHWTEPTKFIPERFTPEAKA-R-RHPFVYLPFGAGPRSCVGMRLAQLEIKVALVHIFRRFNVLACEDTPLESHTTLGPKNGVMVKITER