This PDF file includes:

• Fig. S1. Particle size distribution for compounds 2 to 5.
• Fig. S2. TEM photographs of compound 5.
• Fig. S3. Expression of APC maturation markers MHC-II and CD40 on CD11c⁺ DCs and F4/80⁺ macrophages in response to stimulation with vaccine candidates.
• Fig. S4. Expression of APC maturation markers CD40, CD80, CD86, and MHC-II on CD11c⁺ DCs and F4/80⁺ macrophages in response to stimulation with vaccine candidates in vivo.
• Fig. S5. ELISpot analysis of IFN-γ– and IL-4–producing T cells.
• Fig. S6. Antibody titers measured in two distinct in vivo experiments.
• Fig. S7. Photos of mouse tails 55 days after primary immunization.
• Fig. S8. MS and HPLC spectra of compounds 1 to 5.
• Fig. S9. Latex agglutination test results of bacteria collected from the challenge experiment.
• Table S1. Particle size distribution for compounds 2 to 5 analyzed by intensity.

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