This PDF file includes:

• Fig. S1. Awake fMRI system and physiological parameters.
• Fig. S2. EEG recording.
• Fig. S3. Head motion parameters.
• Fig. S4. Similar BOLD response to odor stimulation in the olfactory bulb between WT and 15q dup-saline mice.
• Fig. S5. Common ICA components in WT and 15q dup mice.
• Fig. S6. DMN in WT and 15q dup mice.
• Fig. S7. Modular decomposition of functional connectivity networks and comparison of within-module–averaged connectivity.
• Table S1. Amino acid concentration in hindbrain in WT and 15q dup mice.
• Table S2. Amino acid concentration in forebrain in WT and 15q dup mice.

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