This PDF file includes:

• Supplementary Materials and Methods
• Scheme S1. Preparation and tumor-targeted delivery of dual pH-sensitive nanodrug.
• Fig. S1. The synthetic route and ¹H NMR spectra of copolymers.
• Fig. S2. Characterizations of copolymers, antibody, and nanomicelle.
• Fig. S3. T cell binding and cellular uptake of nanodrug at pH 6.5.
• Fig. S4. Cytotoxicities of nanomicelles and concentrations of CUR in tumor tissue.
• Fig. S5. PD-1⁺ T cell binding of NR@PPC–aPD-1 in vivo.
• Fig. S6. T1WI signal intensities of tumors and T1WI of the B16F10 tumor-bearing mice.
• Fig. S7. CLSM images showing the colocalization of aPD-1 and PD-1 and intratumor distribution of nanodrug.
• Fig. S8. In vivo immune response regulated by nanodrug.
• Fig. S9. Schedule of in vivo study and biosafety of nanodrug.
• Table S1. Molecular weight of the synthesized polymers.
• Table S2. Sequences for forward and reverse specific primers for real-time reverse transcription PCR amplification.
• References (36–40)

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