This PDF file includes:

• Fig. S1. Variants of antibody 1B7 bind PTx equivalently by ELISA.
• Fig. S2. Dosing hu1B7 in the mouse challenge model.
• Fig. S3. Temporal data for WBC count and bacterial colonization for each treatment group.
• Fig. S4. Temporal correlation of anti-PTx and WBC counts for each baboon.
• Fig. S5. Temporal correlation of anti-PTx and antidrug antibody titers for each treated baboon.
• Fig. S6. Pearson correlation of antidrug antibody titers and anti-PTx titers.
• Fig. S7. Presence of 1B7 does not interfere with anti-PTx responses due to vaccination.
• Table S1. Baboon raw data.

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