This PDF file includes:

• Fig. S1. Sequence alignment of different domains in IGF2R.
• Fig. S2. Biochemical characterization of apo state IGF2R and IGF2-bound IGF2R.
• Fig. S3. Data processing and model quality assessment of apo state IGF2R.
• Fig. S4. Cryo-EM map of apo state IGF2R.
• Fig. S5. Structural comparison for seven subgroups of apo state IGF2R in two different views.
• Fig. S6. Data processing for ligand-free IGF2R.
• Fig. S7. Data processing and model quality assessment of IGF2-bound IGF2R.
• Fig. S8. Cryo-EM map of IGF2-bound IGF2R.
• Fig. S9. Structural comparison of CD-MPR and domains of IGF2R for Man6P.
• Table S1. Cryo-EM data collection, refinement, and validation statistics.

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