>AaegIR21a/1-488 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------SINSESAYV------------------------------------------------------ ------------------------------------------------------------------------ -----------------------LYTHELYI-----------------------------------DGLGSN RPIVLTSW---------------------------------------------------------------- ------------------------------------------INGKFSRP---------------------- --------NLD----------------------------L------FPPK-------IRKG----------- ----------FSGHR-FTVSAAH------------------------------------------------- ---------------------------------------------------------Q-PP--------FVF --------------------------------------KIM------------------------------- -------------STD-------------G-----------------------VGNIAIRWDGLE-M----- ------------RVLRTLGN-Y----------------------L----N----------F----------- ------------T----FDIKE-PSK---------PYL-GS----G-------------------------- --------------------------------DA-------------------------------------- --------------------------VTD---EV--------------ER-K--------------Q---AD IGLA-----------------------------------------------------------GAFVT---- -SER--NVKA--------------EM-S-VS-----HSTDC---AAFVT-----------LMSSS------- -------------------------------LPR--------YR------------AILGP---FQ------ ----------------------------------WPV--W-LAL-TLVY------LM-AIFPLAFSDKLSLR HLIGNW------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------T--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------EIEN-----MFWY---VFG--------TFTN-SLTFTG- --------ENSWSNTKKTSTRMLIGI------YWV-----FTIIITSCYTG-----SI-----IA-FVTMPV V--PD-----------------------TID-----SVEQLKSGFFR------------------FVTLD-- -------------------------RGGWE---------------RWF----L------------------- -------------N----------------------------------SS-DE--------TTEKL------ ----------------IQRL-------------------------------------KFVSNLDE--G---- IRNVTEAF----LI-----------S-Y-A-FIGSKAELNYLVQSNFSD-----------ESANKRYT---- -----LHVSKEC-FSL------------------------------------------FG--------VSYI FQLN-S-V-------------------------YRDKFNNA-----------ILYMQEAGILTKLSKDVS-- ---WDM-------------QKTK--------------------------------NGRFRQA-SVGKVLKV- -------------------PTAG-EKGLTLGDTEGMFLLMG-------------VGYLI-GLA----VLISE WV---------------------------------GGCTN-------------------------------- -------------------KCREI-IKARK------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AaegIR25a/1-914 ------------------------------------------------------------------------ ------------------------------------------------------------MQIS-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------VFVNEVGN--------------------------------------- ---------------DLAQVAVDVAL-----------NYIRKNPSL----------------G-LSVEL--- --LTVEG-NR-TDSKGL--LESLCSKYTEAINTN--R-PPHVIF---------------------------- ---------------------------------------------------------------------DTT LTGV--------------------SSETVKSISAALGI-----------------PTVSASTGQEGDLRQWR SLSNVKSNYLLQV---MPPTDIIPE--------VIRAI---VTY-MN------ITNA--------------- -----------------------------A--------ILYD-ESFV------------------------- ---------------------------MD--HKYKALLQNF-----------------------PTRHVITA IG----------------------ND--RDR-----------AEQIEKLRNLDINN---------------- --------FFI-------LGS--FASIK-------------------------------------------- -----------------------KVL-----------ESA------------K-R---EFFE---------- ----RNF--AWHAI----------------------------------------------TQY--------- ----------------------------------QGELSSN---------IENATIMLLRPVSD-------- ----SKSKDRLGVIRTTYNMKQE-----PQI----------------------------------------- -------------TTVFYF----D--------------------------LALR--TFLAI-K--------- ----NILQVGA-------------------------------------------WPPNMKYLTCD------- -EYD-GTNSPNHT--IDLKSA---------------------------FIEVT------------------- -----EPTTYGPFEFPK-GK------------------------TPFNGHSFMK------------------ -------------------FDMDISAVTIRG-------------------------------------GASV STKNLGKW--------------------------------------------------EASLD--NA----- --------------------------------------------LYV------------------------- ----------------------------TSEDDM------------------------KNL----------- ----------TADIV-YRVYTVV------------------------------------------------- ---------------------------------------------------------Q-EP--------FII ------------------------------------------------------------------------ -----------RDP-T-------------AP---------------------------KGFKGYC-I----- ------------DLLDEIAK-I----------------------V----K----------F----------- ------------D----YEIKE-VED---------GK-FGN------------------------------- -----------------------------MNEKG---------------E---W------------------ NG------------------------IVR---KL--------------ID-K--------------Q---AD IGLG-----------------------------------------------------------SMSVM---- -AER---ETV--I-----------DF-T-VPY----YDLVG---ISI-------------M-MLL------- --------------------------------PST-PS--SLFK-------------FLTV---LE------ ----------------------------------TNV--W-LCI-LAA-------YF-F---TS-----FLM WIFDRY------------------------------------------------------------------ --------------------SPYS-YQN-------------------------------------------- -----N------------------------------REKY-----------------KND------------ ------------------------------------------------------------------------ ----------------------------------DEKR-EF------------------------------- ---------------------------------NIKE-----CLWF---CMT--------SLT-----PQG- --------GGEA--PKNLSGRLVAAT------WWL-----FGFIIIASYTA-----NL-----AA-FLTVSR L--DT-----------------------PVE-----SLDDLSKQY----------------------KIL-- -----------YAPLN---------GSSAM---------------TYF----Q------------------- -------------RMADIEARFYEIWKEMSLNDSLTPVERSKLAVWDYPV-SD--------KYTKM------ -WQAMQEA---GL----------------------------------------------PNSLDE--A---- VERIRNSTSA-----S---------G-F-A-FLGDATDIRY--------------------KVLTNCD---- -----LQMVGEE-FSR-KP-------------------------------------------------YAIA VQQG-S-P-------------------------LKDQFNNA-----------ILMLLNKRQLEK-------- ---L---------------KEQWW-------------KN-------------DDIQSKCEKPDDQ------- ------------------------SDGISIQNIGGVFIVIF-------------VGIGM-ACI----TLVFE FW---------------------------------YY-KY-------R-KNV-------------------- ------------------------------------------------------------------------ ------------------------------------KIID-VAEATEDK--------------------LAQ KTSNLRLPN--------------------------------------------------------------- -----------------------------------------------------LKNEFGAMGQ---IK---- -----------DDSQ--------------------------------------------------------- --------------------------------------------KTQSL---RTRTQTI------------- ---------------------------------------------------DANNFKSRF------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AaegIR31a/1-482 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------M------------NS-FS--------------------HL---------------------- -----------------------N------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----GVQ--MN-SDITVAL----------------------------------------------------- ------------------------------------------------------------------------ ---P--------------------------------------------KNAS-------------------- -----------------------------------------------D-ES--------------------- ---------------------FD--LLAVYSPGRHL----------------------------CKD----T YQYKYGEW--------------------------------------------------NMKNGV-------- ------------------------------------------------------------------------ -------------------------------------I-V------VPGF-SIY--NERAD----------- ----------FKGLR-LR-GVT-------------------------------------------------- -----------------V---------------------------------------I-DRNNVTS-EDV-- ---------------------------------------DRIL----------------------------- -----------SAAGR--------------------------------------QQGVVLFIKYH-Y----- ------------AILAILRD-Y----------------------H----N----------F----------- ------------T----IHYRI------------ARG-WAGRL----------------------------- -------------------------------KSG---------------F---R------------------ LG------------------------LLG---IM--------------AR-N--------------E---AD VATT-----------------------------------------------------------GILHR---- -TNR---HAE--F-----------DF-IHFS-----WEFT----TGF-------------L-YRM------- --------------------------------TPQLRDSSGSG-------------SFWTP---FD------ ----------------------------------GMV--WLASA-VTV--------------IT-----VLF VLKLV------------------------------------------------------------------- ---------------------LLIISKIKLYEPT-------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------RNG----------------------------------- ---------------------------------PFMS-----YIVD---VIA--------TIA-----QQGS ---------SNQV-SGRISIRIIIFS------LLF-----LTLLLYNYYTS-----SV-----VGGLLSSPG ---K------------------------GPY-----TIKEFTDSPLT------------------------- -----------LSFH----------DIGYNK--------------VLF----A------------------- -------------E----------------------------------SK-DP--------TIREM------ -YRK-KAE---PSREGKNTI-----------------------------P--------VYADVST--A---- VPYLK----------Q-G-------G-Y-A-FHCEFTEVFEEIANQFDA--------------YEICELRT- -----GASLFS-DLNI----------------------------------------------------IGMI LPKR-S-M-------------------------YSEIFKT-----------TLIRAQEIGLIKR-------N LRRYRP-------------------------------EKP-----------------TCQA----------- --------------------GSRI-HPVEFHSVRTAFAILG-------------GK---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AaegIR40a/1-812 -----------------------------------------------------------------MNKVLAT PASKADK----------------------------------------------LESLISIGLVVQNLCSQLQ SMRM------------------------------------------------------------EAHLSNPS LLQELVDK-------------------------------------------------------------LPA N-------IKLHW----------------------------------------------------------- --------------------------------------------------------------ALHQ------ -----------RQVPVV------------------------------------------------------- -------DFRAF------------------------------------------------------------ --------------------------------TYHAHLAPL------------------------------- --------------PDLSNHSGMVLG----LSEMINLLAP-------------------------------- ------------------------KTLAIL--------VLKE-TKIDK------------------------ ---------------------------ID--RLTVMIHHH------------------------NIPTCIFN ------------------------------------------------------------------------ ----NQDEYFQ------YIGNNLKKSLE-------------------------------------------- ---------------------TTSLL------FCHPEE---------MLGELIDR---RLAHR--------- -------LSLYIFY----------------------------------WGA--------------------- ------------------------------------------------------------------------ ------------------------RKAPTNLDRS--------LM---------------------------- ---------REPLRVAVIT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------NPRKNIF-------------------- ----------------------RIFYNQ-------------------------------------AKPNNRG ELLSANWF---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------DGNDMTFQKVP-----L------LPTP-TTV----YKN----------- ----------FEGRV-FTIPVIH------------------------------------------------- ---------------------------------------------------------K-PPW------HFVT -----------------------------------YRKVNESS----------------------------- --------------LNETDVDQ-----------LE---------------LSANGTDNEQLEVFE-V----- ------TGGRDHNLIQLIAH-R----------------------M----N----------F----------- ------------S----FKYVD-QEDRI----------QGTAV----------------------------- ----------------------------GPPENA---------------I---F------------------ TG------------------------ALG---ML--------------QR-R--------------E---VD LFLG-----------------------------------------------------------DVAVT---- -WER---MQA--V-----------EF-S--------FFTLADS-AAF-------------V-THA------- --------------------------------PRK-LS--EAL-------------ALVRP---FQ------ ----------------------------------VAV--W-PLV-LLT-------IM-M---SG-----PIL YMIIAMPYRLEDWARG-------------------------------------------------------- ------------------TMARRRRFKVQ------RG----------------------------------- -----SAFY---------------------------HMQYIQEMNYGTLPG-GA-EIAGTPRH--------- ------------------------------------------------------------------------ -----------------------------------PS----------------------------------- ----------------------------------LDR-----CIWY---TIN--------VYL-----RQS- --------A-TIP-YNGHVSRFFSIL------LWLC----ATYVLGDVYSA-----QL-----TS-QLARPA R--EG-----------------------PID-----TLGKLEVFMER-------------------DGYQ-- -----------LLVER---------QSAFQ---------------AAL----V------------------- ------------------------------------------------NS-TG--------ILQRL------ -YRITQRQSHNE--------------------------------------------SYLVSSVEE--G---- IRILV----------D-N------SK-R-A-VFGGRETLYFNTKRYGAHR---------------------- -----FQLSE--KLYTRYS--------------------------------------------------AVA VQFG-S-P-------------------------FLDSLNEV-----------IMRLFEAGIIEK-------- -----------------ITIAEYERMFGSQL-G-QFGDE------------------SAKTTKPESFET--- -------E-GGKSKKSTESNEK--LQPMNLRMLQGAFLALA-------------CGHSL-GVL----TLVLE N----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------KTKCIQ-----I-SFGWI------------------ ------------------------------------------------------------------------ -------------------------------------KAW------------LHRIGLIFCKLGKVVWRSW- ------------------------------------------------------------------------ -----------------------------------------------------RRLH--------------- ------------------------------------------------------------NDD--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AaegIR41a.1/1-551 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------MMDSIE------NGC------------- ------QSFII-----------TQQASQ-------------------------------------------- -----------------------TFLDD--------FNFLHD----------RTIT--QHSN---------- --------KKIIIL----------------I-----------------------------DSQTSEM----- ------------------------------------------------------------------------ -------------------------ATDQIFQHD--------AI---------------------------- ---------HDIPQLLLLI----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------PKG-Q-DR--------------------- ---------------------IDLMTNRFVT------------------------------------QDHHH ELILLDRF-------------------------------------------------VPSLGTFMY------ AS---------------------------------------------------------------------- -------------------------------------D-L------FPNK--------LHD----------- ----------LEGRF-LRLALFK------------------------------------------------- ---------------------------------------------------------Y-HP--------YTI WNEV-------------------------------------------------------------------- ------------SSID------------ESNANYEQ-------------------KPTLSIDGTE-S----- ------------RIFLEFCS-T----------------------F----N----C----------------- ------------S----LDISLDEAGE-----------WGE------------------------------- -----------------------------IFDNR---------------T--------G------------- NG------------------------IIG---AV--------------VE-R--------------R---AD IGVG-----------------------------------------------------------ALYSW---- -HHE---SIY--L-----------SL-S-KP-----ISRTG---VTC-------------I-TPK------- --------------------------------PRLLSG----------------WLIPILP---FS------ ----------------------------------QNL--W-IAV-LST-------FL-C---MS-----CFS LFVNYM------------------------------------------------------------------ -------------VD--NVL---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------NKENRRVDLC-------------ES--------------- -------------------------------------------FMI---IGS--------IFI-----LQSV L-------LRINR-SKLVSQLIVMGS------LLF-----VGLMIGNLYSG-----GL-----SS-IMTIPR Y--EP-----------------------PVD-----TLEDLANS-----------------------NLP-- -----------WASTHD----------------------------AWIFSI-L------------------- -------------M----------------------------------AT-QPT-------II-RI----LH NFQTHPKEV----------------------------------------------LHKHTKQLDM--A--YS VERLP-------Y----G-------H-F-A---------------------------IGEYIDEEASH---- K----FHLMKEDIYWE----------------------------------------------------NCVA MSTK-TWP-------------------------MMDQLDQL-----------ILIIFQSGIQRY-------- ---WEL-----------QVVSKYE--------N----DE---------------VQLAIATSRHPEND---- -------G----------------PIVLQLSHLLGAFLMLG-------------FGLAA-GLA----TFMVE VMLG----------------------------------KF-------M------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AaegIR60a/1-682 ------------------------------------------------------------------------ -----------------------------------------------------MHLACLIFFLLCKSF---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------SSGIVYVRMKNERG---------PMAVQAGIN-------- ------------------------------CLELLTDSYFH---NRD------SSQIQ-------------- ------------------------------------NLVIFHLDNL-------------------------- -------------------SSPS-----R--EIELGYLQNHH--------TGY------EEMAYG-GTQIFQ ---------------------------------------------LKVMSDV-------------------- ---------LP------------VESLR-------------------------------------------- ---------------------NVHFV---------DYKLI-----DFYVIVADEME--KLERAMRYVSS--- AYAFNPR-GKFLILYNN-------------------------------------------PNNRDHEELFA- ------------------------------------------------------------------------ ------------------------LEVLKLLFFG-------------------------------------- ---------HHSVNVLVAY-------------------------------------------A--------- ----------------------------------------V------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------DLMTYNVYTGDPYHGTQ--------------------------------NDCGKM KALKIATI---------------------------------------------------------------- -----------------------------------------------------------------------V NG-----------------------------------T---------------------------------- ----------FRNKA-SAITSIR------------------------------------------------- -----------------MP--------------------------------------KVPPE--MKSCTFNL ------------------------------------------------------------------------ ----------------------------CARV-------------------ASPFVNEGCKTGLE-L----- ------------EIMRLLQE-S----------------------M----K----------F----------- ------------N----VNISCSTME------------RGE------------------------------- -----------------------------LMEDN--------------IT---W------------------ SD------------------------LLG---KL--------------RA-D--------------E---CD I---------------------------------------------------------------IVGS-FY- -PDF-------DVHI---------DFAG-TSL----YLQDY---YTW------------FVKLAG------- --------------------------------LES------RWK------------VLLMI---FE------ ----------------------------------VPT--W-QLI-ALS-------LL-I---S------SIS WYFIGS------------------------------------------------------------------ -----------------------------------------------------------AL----------- ------------------------------------------------------------P----------- ------------------------------------------------------------------------ --------------------------------ESNAHK---------------------------------- ---------------------------------LLST-----CFLN---TWC--------VFL--CVSTNN- ------R-------PMCSSLRIFFIA------SAL-----YAMNLTTIYTS-----LL-----II-FFTSPP R--MH-----------------------QID-----SIDEILAANFQ------------------------- ------------------------IGGRMEYE-------------DWF----D------------------- ---------------------------------------------------NG--------DERDLRV---- -SRLYDNSD------------------------------------------------DFQPSHTN------- LKAVS----------L-GK------R---V-MLTSRMYV-------------------------KSSHFRDA -----VHGLTLDSFAN----------------------------------Q-----------------LELI VEKG-F-P-------------------------LLPKFNRI-----------ISNLNDMGIVEKL------- ---FND-------FLYNVTILEQI-------------EEI------------VNPNEDDDHSLGSGRDE--- -------------------------IVLTTDHLQSAFFFYF-------------VGVVI-STV----VFFGE VFFN--------------------------IPKHKSDGNLIPNNI-TMLRAQYVG----------------- --------------W--------------------------------------------------------- -----------------------------------CTLSRKEKNK--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AaegIR64a/1-657 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------AS--------------------RY---------------------- -----------------------ELL----------NG---------------S------------------ --------FHWLIIDKKPNVDSSIGTANAFARTIAVAASDSE-------------RWTNEYRYRSAEHGPGC HPLANFTKPSNPPGE--HYGLTAAANR-------DQERPGDDDDA-----VGDY------------------ -YDTGPVDGDVV------------DEIFGRFETM-------------------------------------- ----NIS--IN-AEITLVK----------------------------------------------------- ------------------------------------------------------------------------ ---A--------------------------------------------LA---------------------- ------------------------------------------------GDA--------------------- --------SH---------RDFA--LFDIWNPGFISG----GRL---------------------------- NVTAMGNY--------------------------------------------------TADQHR-------- ------------------------------------------------------------------------ -----------------D---GNGLLYVRFREST------------------VV--RRR-D----------- ----------MNGLR-LKIMTV-------------------------------------------------- -----------------V---------------------------------------T-QKP---RE-PFE- ---------------------------------------VYL------------------------------ ------------STPK--------------------------------------NTHLDSVHRYN-F----- ------------GLMSYLKD-Y----------------------F----N----------F----------- ------------R----FIMRR------------TKS-WG-------------------------------- -----------------------------YLRNG---------------T---F------------------ DG------------------------MIG---AL--------------AR-R--------------E---VD LGGS-----------------------------------------------------------PMFFR---- -QER---HRV--V-----------SY-TTRS-----FIER----PCF-------------I-FRH------- --------------------------------PRRQQTMRN---------------PFLLP---FE------ ----------------------------------TTI--W-YMM-VAC-------GA-I---LV-----VVL FTSFYFEDS--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------AEKFS---------------------------------- ------------------------------------K-----SILL---FLG--------GVC-----QQG- ---------LSEI-PHLPSGKCTSMF------ILI-----FGYLMFQYYSA-----TI-----VGSLLMVPP ---K------------------------NIR-----TIRNLIDSKLT------------------------- -----------LGIE----------DIPYSR--------------DYF----V------------------- -------------R----------------------------------TT-DE--------DSLEL------ -YRT-RVSF-YNPKTGQNE--------------------------------------SHFLNAAD--G---- LALVK----------A-G-------G-Y-A-FHVAVSAGYKIIRETFSE--------------REVCELAE- -----IDMFPK-SAQW----------------------------------------------------MVAI VQKN-S-P-------------------------YRDVITY-----------GLRRLNEAGIMDH-------Q RHVWQE-------------------------------PKP-----------------KCVRK---------- --------------------MAPTDLIVGLDSVYSAFILLL-------------AGALV-SIG----LLLIE IL---------------------------------H-HQL-------R-LAKNGWPS--------------- ------------------------------------------------------------------------ --------------------------------RHQHHHHRR------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -FNVGNFPQQQKPPLQ-------------------------------------------------------- ----------------------------------------------------GQQLWDHDLV---------- -----------------------------------------------YPYVD-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AaegIR68a/1-522 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------F-----------------------------------PFPLRGVF ISRRLDFW---------------------------------------------------------------- ------------------------------------------------------------------------ --------F-----------------NGKFRKGR---K-L------FSDK--------TTN----------- ----------LDGQS-MKVVVLE------------------------------------------------- ---------------------------------------------------------H-TP----------- ---------------------------------------AIFR----------------------------- ------------TTHNET----------D--------------------------EHLK-YYGLE-V----- ------------ELLKAISE-A----------------------M----K----------F----------- ------------E----MDFYE-SDDA---AV---AM-WGT------------------------------- -----------------------------VTDGE---------------N---A------------------ TG------------------------LLG---EMMSHKFLHCFNYVFQNE-G--------------H---AD FALA-----------------------------------------------------------DLHHT---- -QYH---LEI--M-----------DL-S-IP-----YNTEC---LTF-------------L----------- -------------------------------TPEA-LT-DNSWT------------TLILP---FT------ ----------------------------------GGM--W-AGV-LAS-------LF-S---IG-----TVF YALSRLL----------------------------------------------------------------- -------------------M--FVRHEQS------------------------------------------- YRSDLDMI--------AKRSR-----------KRNRKVHF--------------------KI---------- ------------------------------------------------------------------------ -----------------------------------VCG-MVNSYKRAL--------DPLPP----------- -----------RDIFD-----------------TFSG-----CIIY---TYS--------MLL-----LVS- --------L-PRL-PKGWPLRLLTGW------YWI-----YCILLVVAYRA-----SL-----TA-ILANPV A--RV-----------------------TID-----KLKDLADSPIR-CG---------------------- -------------------------AWGEQ-------------NKLFF----Q------------------- -------------S----------------------------------AS-DQ--------VSMQI------ ----------------GQKL-------------------------------------EHTPKAEA--A---- VERVV----------E-G-------H-F-A-YYDNVYMLKHLRA------------TRKSAKARE------- ----TLHIMEEC-AVH-MP-------------------------------------------------ISIG LEKN-S-P-------------------------LKPKVDKY-----------VRALVEAGLTKK-------- ---W---------------LADAI-------------EEF-------------------------------- ---------------QSNVEIPPQEATMDLQKLTAAFIALA-------------IGYGV-SLL----AFSAE KL---------------------------------YW----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----RFVVEKHPAYDKYIVGSYR-----------GKVVRF------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AaegIR75d/1-646 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------M---------------------------------------------------------------- ---------------------EVTKLYY-------------------------------------------- -------------LCILFSLLLSVRAIEWN--------------------------------DFFEVSNA-- -----YFKARHVRLLTV----VNC------------------------------------------------ ------------------------------------------------------------------------ -----------------------------FNTVDNFQLTKNYL----------------------------- -----EAGY----------------F-----VRIVEEFD-------H------FN-VSGN------------ ------------------------------------------------------------------------ -----------------------GNSGV-----------------------------------------VVD GLC------------------------------------------------------E-------------- ------AK-MR------------QLLAI--------------------N----------------------- --------------------SLNEFM----------QT---------------N------------------ --------IFWLFLEDG--------------------------HE---------------SVGDKLD----- -----------------------VPD---------------------------------------------- -----------------------------TIRTRYND----------------------------------- -DFKHVEALPG-SSIAVGVF---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------QSS--------------------- ---------------------WR--LFDVHKKHSKGS----LIF---------------------------K DICYHGRN--------------------------------------------------LMESTN-------- ------------------------------------------------------------------------ ----------------------MQRALLRFNKNL----------------------KERRN----------- ----------LRGYR-MPTAIA-------------------------------------------------- -----------------I---------------------------------------T-SP-------EKH- ---------------------------------------TGI------------------------------ ------------NDMS--------------------------------------DTFHDLYAKST-F----- ------------PLIKELMY-D----------------------V----N----------F----------- ------------T----INMIQ------------VDL-GGWKI----------------------------- --------------------------------NG---------------T---F------------------ NG------------------------LMG---LL--------------AN-R--------------T---VE LVAM-----------------------------------------------------------GVLMR---- -SER---MEV--S-----------DF-ITVA-----FLLK----TCF-------------I-FKQ------- --------------------------------PPLSLV-SN---------------IFELP---FS------ ----------------------------------GQV--W-LSC-LGF-------II-V---CW-----ITM MSVRFFARRENL------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------T------------------------------------------ ------------------------------------------------------------------------ ----------------------------------PGD-----SLTF---IIG--------TMC-----QQD- ---------INLS-AHFNSTKFLFFV------AKL-----ASFFIFTAYSA-----TI-----VA-LLQSPS ---R------------------------AIR-----SVDDLTASPLK------------------------- -----------VGAM----------DTVYTW--------------VYL----N------------------- -------------E----------------------------------AK-DA--------QVQNL------ -FQK-KIK-----------------------------------------RYGK----NSLIEADV--G---- MRRVK----------D-E-------L-Y-A-FQVESNAAYLFIKQTFTP--------------QDTCKIHE- -----LEAIK---VAP----------------------------------------------------FAIP VRKG-S-K-------------------------YRELFRQ-----------RLIWQMEVGIKHR-------A NRIWIA-------------------------------HKP-----------------KCES----------- --------------------GVVAFNSVGLKELRFLYILLP-------------VGVAL-AWF----ILGAE LY---------------------------------W-----------K-KKLQKVEE--------------- ------------------------------------------------------------------------ -------------------------------GSKTSPSDGEE------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------VMNEIKL KLVY-------------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------DGYLN-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AaegIR75i/1-600 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------MFAASS----------------------------------------- --------------------FVEHSLIS-----------------------------------GFT------ -------SHKTINAIIM----FHCG----------------------------------------------- ------------------------------------------------------------------------ ----------------------------PSESIASLYAYSKS------------------------------ -------FLSIYV----PSTTFYTNH-----YRFMSTGDHRF------------------------------ ------------------------------------------------------------------------ -------------------------GL------------------------------------------IAD L--------------------------------------------------------SCPST---------- ------KD-LL------------QF-CS--------------------DR---------------------- -----------------------SYF----------NE---------------S------------------ --------YRWLLVNGV---------------------------D---------------S-NYTFS----- ------------------------------------------------------------------------ -----------------------------YLESL-------------------------------------- ----NLN--ID-THLTLAIR---------------------------------------------------- ------------------------------------------------------------------------ ---N--------------------------------------------LDQV-------------------- -----------------------------------------------EGS---------------------- ---------------------YE--LFEVYGTIRRRG----GKN---------------------------- HVVKVGFE--------------------------------------------------NSGTG--------- ------------------------------------------------------------------------ -------------------------ISLDRTHNN------------------LA--KSRTC----------- ----------LDGLP-LRAVVT-------------------------------------------------- -----------------V---------------------------------------K-IQI--FRCISNK- ---------------------------------------DYL------------------------------ ------------LNLD--------------------------------------PPRSFSSDRLG-Y----- ------------QMSVLLSE-F----------------------L----K----------F----------- ------------R----IQLII------------ADD-WH-FN----------------------------- -----------------------------EIDTN---------------S---S------------------ KG------------------------VIG---QL--------------QN-N--------------L---VD FSIA-----------------------------------------------------------PLSLR---- -TEN---VAA--F-----------DV-IMPI-----TATR----VMI-------------V-FRH------- --------------------------------PKNSFT-RN---------------IFLLP---FR------ ----------------------------------NTV--W-AAV-STI-------MI-V---AC-----TFL LVDLYIKTRTNFYE---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------TC---------------------------------- ------------------------------------E-----ILLT---VLG--------FLG-----RQP- ---------MTSG-IDLASARIVIIA------SIF-----FCFIVHQFYST-----FI-----ISYLLVSPP ---K------------------------SIQ-----TVEDLLSSNLK------------------------- -----------CGIE----------DFAYNL--------------DFF----N------------------- -------------T----------------------------------TK-DD--------IALKL------ -YKN-KIL--------TNK--------------------------------------HGLTDINT--G---- IKLVK----------R-G-------G-Y-A-FLMDCSYGYPLVFESFNE--------------KQICDLHE- -----ISLLP---LQP----------------------------------------------------LYLA VPKG-S-P-------------------------LKEAFRI-----------MLRRAVETGSTDR-------Y NRIFNS-------------------------------RKP-----------------RCTMK---------- --------------------DATFD-QVQLVDIASLYRFLA-------------LGGAL-GMG----ILLVE II---------------------------------E-SRI-------R-T---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------YFE---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AaegIR75l/1-599 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------MTC------------------------------------------------ ------------------------------------------------------------------------ -----------------------------WDYSEKVKYFN-------------------------------- ------------------A-----LN-----DRYLTSFS--------------------------------- -----------------------------------------D-DHIDQFV-EDIND---------------- -----------------------HQTFL-----------------------------------------IVD IN--------------------------------------------------------CPNT---------- ------RH-LL------------AA-AG--------------------K----------------------- ------------------------LL----------YI---------------K------------------ --------YRWLILHTGFSAM-----------------------N---------------HP-SPEK----- ------------------------------------------------------------------------ --QKQLFLE--------------------KLVDL-------------------------------------- ----PLL--IS-SEIFLLI----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------KEQE--------------------- --------GL-----------YR--IQQVFKQSTDAP----LDV---------------------------- --EPFGTW---------------------------------------------------------------- ------------------------------------------SNGSMVDN---------------------- -----------------------------RRTQV------------------TS--IRRLN----------- ----------LNGHT-LKASLV-------------------------------------------------- -----------------I---------------------------------------T-NP-------DTL- ---------------------------------------HHL------------------------------ ------------TDYK--------------------------------------DKHIDTITKVN-Y----- ------------ILTNCLVQYY----------------------L----N----------A----------- ------------R----VNYSI------------VST-WGYFN----------------------------- ------------------------------TTTK---------------R---W------------------ DG------------------------MIG---EL--------------SQ-N--------------V---AD LGAS-----------------------------------------------------------PLFFT---- -TDR---IAV--I-----------EY-VAMT-----SATR----SKF-------------I-FRS------- --------------------------------PKLSYT-EN---------------VFLLP---FD------ ----------------------------------DLV--W-ICT-AMV-------IF-L---AS-----CLL VITARAEW---------------------------------------------------------------- --------------------------RVP------------------------------------------- ---------------LTVDD----------------------------------------PSDGS------- ------------------------------------------------------------------------ ---------------------------------ILRAS---------------------------------- ----------------------------------LRD-----TLLM---IYG--------ATC-----QQG- ---------SSTL-PRSFSARTITMI------TFT-----VLMFLYVCYSA-----NI-----VA-LLQSPS ---T------------------------KIR-----TLEDLLASRLK------------------------- -----------FGAH----------DTVFNR--------------YYF----T------------------- -------------H----------------------------------AT-EP--------TRQAI------ -YER-KIK----QQDGS----------------------------------------ANFINLEQ--G---- IDRIR----------R-G-------L-Y-A-FHVEQGVGYKVISETYQE--------------DEKCGLQE- -----IQYLQ---VID----------------------------------------------------PYYA IQKN-S-S-------------------------FKEHIKI-----------GLFRLNEHGIQHR-------E NSNLYT-------------------------------KKP-----------------KCTG----------- --------------------GGGKFVPVSLVDTEPAILVIV-------------WGTGL-AAA----IFVSE LA---------------------------------W-VKG-------M-RK--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------YRD--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------WKGSHVVKMVYTDYID------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AaegIR75o/1-483 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------MQ---------------K------------------ --------FKWILFDSH-------------------------------------------AVNQNAT----- ------------------------------------------------------------------------ --DV----------------------------AI-------------------------------------- ----PQL--IH-SEVFLIT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------ENAN--------------------- ---------H-----------YN--IWQFSKLFPTYP----TTR---------------------------- --QLYASW---------------------------------------------------------------- ------------------------------------------RLDSVPHL---------------------- -----------------------------QLNSE------------------VF--ADRWN----------- ----------LQGAR-LKASVV-------------------------------------------------- -----------------C---------------------------------------S-SS-------E--- ------------------------------------------------------------------------ ---------------------------------------------------------INTSAKAD-K----- ------------AVTTALAN-I----------------------L----N----------A----------- ------------S----VTFHC------------TPN-WK-------------------------------- ------------------------------------------------------------------------ QG------------------------LIH---DL--------------RT-R--------------S---TD LGAT-----------------------------------------------------------PSYMT---- -PDR---LKS--V-----------QF-LAMT-----GPLD----YKF-------------I-YRS------- --------------------------------PKLSYT-DN---------------VFLLS---FH------ ----------------------------------DRV--W-LSI-GAV-------IL-L---AT-----ALQ MIITRFESDH-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------PE---------- ------------------------------------------------------------------------ -----------------------------------QLG---------------------------------- ----------------------------------VSD-----ALLN---MIG--------IAS-----QQE- ---------ALIN-PQSVSSRTLNIV------MLI-----SLMFLYICFSA-----NI-----VA-LIQSPT ---A------------------------RVR-----TLGDLLRWGFE------------------------- -----------LSAQ----------DSDINR--------------IFM----A------------------- -------------N----------------------------------ES-NS--------LRSTI------ -YTT-IQN----S--------------------------------------------NGFLPVAN--G---- TERIR----------Q-G-------L-A-A-FHGDTNQIYRYMIDQFDE--------------NEKCNLNE- -----INFLP---PLQ----------------------------------------------------GYYT VAKD-S-P-------------------------LAEHVKY-----------GLLKLRELGFLQR-------E IAMHYQ-------------------------------RKP-----------------ACI------------ --------------------GENLFVPISMIDAIFSIQLMG-------------WALVL-TIV----IFALE VT---------------------------------W-------------KRYN------------------- ------------------------------------------------------------------------ --------------------------------------ANL------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------FVVR--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------WIQRKIAKHKNK----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AaegIR76b/1-483 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------ME-K----------------------F----K----------F----------- ------------N----YTLVM-PEH---------NI-VGST------------------------------ -----------------------------KDMEG-------------------------------------- -S------------------------IIE---LL--------------AT-E--------------K---AD IAVA-----------------------------------------------------------FLPIL---- -ADA---RQY--I-----------LY-S-AG-----LDEGE---WMM-------------I-MVR------- --------------------------------PME-SA--SGS-------------GLLAP---FN------ ----------------------------------RDV--W-ILI-LVS-------LL-A---VG-----PII YGMLIV------------------------------------------------------------------ --------------------RYKM-T---------------------------------------------- -----------------------------------------------------------KD----------- ------------------------------------------------------------------------ ----------------------------------KEQV-LY------------------------------- ---------------------------------TLPH-----CVWF---VYG--------ALM-----KQG- --------S-TLS-PTGDSTRILFAS------WWI-----FITILTSFYTA-----NL-----TA-FLTLSK F--TL-----------------------PIN-----NAEDVRK-----------------------KEKQ-- -----------FVTIR---------GNAIE---------------YAI------------------------ -------------K----------------------------------NS-DE--------TLNSL------ -SFLVDKH---LVE--------------------------------------------FTTNLND--S---- DILMT-------TVSK-K-------N-Y-V-YVRDRPAIEHLVYKDYLVRR-----KVNPINERSHCP---- -----FATATTP-FLK-RV-------------------------------------------------RAFA YPNT-T-R-------------------------WNTLFDPQ-----------LLNMVEGGLVKF-------- ---K---------------LLENL-------------PK-------------A---EICPQNLGG------- -----------------------TERQLKNRDLVMTYLVML-------------TGFAT-AIA----VFVSE MF---------------------------------F--RI-------L-N---------------------- --------------------ER-------------------------------------------------- ------------------------------------KLNKEQSE-------------------------AAR NRGTDGV---------------------------------------------TYVN---------------- -----------------------------------------------------AKAMGYG------------ --------DSPPPPYAEIFSRHA------------------------------------------------- ----------------SG------------GSMFGSSIDSGSGASRRMI---NGRDYM-------------- ------------------------------------------------------VVKERNGIGSQLI----- ------------------------------------------------------------------------ ----------------------------------------PIRAPS-------------------------- ------------------------------------AAIFQYTYTN-------------------------- >AaegIR8a/1-913 ------------------------------------------------------------------------ ---------------------------------------------------------MWRIVVQW------- ----------------LILELSIGYSGIAAQNS---------------------------------SAVFDE NGNLVIG----------------------------------------------------------------- ------------------------IVVVHEREQPEV------------------------------------ --------------PALTSHAIRSFL-----------GGQNG----------------------VSVF---- --DYYIVYNREHVVFTD--NAELCSALN--------R-GVSVIV---------------------------- ---------------------------------------------------------------------DFT WTD----------------------SNRIMTAANNFNV-----------------PYIHADVS--------- -------------------SQTFLK--------VMENY---LRA-RG------ANDV--------------- -----------------------------V--------HIFD-STEA------------------------- ---------------------------AD--SAIYFLITES-----------------------QLRTIIFD -------------------------CLSDTS-----------IARIKAVRPYP-SF---------------- 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------------------------------------------------------MQSG-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------YENL--------------------------------------- -DFYTHDY---------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------S------ITNT-TKLQLVQSYN----------- 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---WEK-----------RTIRKYL-------------SH-------------RVQEALVEISVGHNED---- ----------------------EELSPLTTQHILGPMIILG-------------IGLFC-SLI----MFLCE LV---------------------------------MF-SL-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------RR----------------FYQKVV- ------------------------------------------------------------------------ ----------------------------------------------------GKKLKT-------------- ---------------------------------------------------TLTDIQK-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AaegIR93a/1-830 -----------MLPR--------------------------------------LK----------------- -------------------------------------------------W-----LVLVLVVCKLDHSR--- ------------------------------------------------------------------GDDFPS ---LI-----------------------------------------------------------------SA N--------------------ASIAVILD------------------------------------------- -REYLDAQ--YDDILEGTKRLFERIL-------RDN---FRN--------------------GGLIVKYFSW --TSI-NLRR-DFTAVL--SISNCENTWDVYKNAAKE---NLVIMSITD----------------------- --------------------------------------------------------------------SDCL R----------------------------LPLNNAIMV-----------------N---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------L--KSIVALSK--ESEDVR-----------------PLSLSLFR IESHT----------------HMW-EKRKAI-----------RKVLVNL--PTRY--IG------------- 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---W---------------LGSYM-------------PS-------------E---DKCSNARKST-E---- ----------------------VENHTVNNDDMAGSYYVLM-------------IGFSM-GLF----MFVLE YG---------------------------------WR----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------WYK--------------------------- ------------------------------------------------------RSK--------------- ----------------------------------------------------EETLQ--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------P--FTE------------------------------ >AcalIR25a/1-747 ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------LLHV--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --YHLIL----------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------LLLSYQTSIA----------------------------------- --PSSRSSCFYMF---KPDIYTKIQ--------IYIYI---------------------------------- --------------------------------------YIYI-YNYY------------------------- ---------------------------LL--VTP----------------------------------LFFG TY----------------------IS-PNCV-----------ASAVKRLLKQKTKK---------------- 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---M---------------KTKWW-------------KE-------------D--EKECPKLENE------- ------------------------TDGISIRNIGGVFLVIV-------------IGSGL-SLI----TLAFE CY---------------------------------WY-RL-------R-PERKT------------------ ------------------------------------------------------------------------ -----------------------------------LSKMY-NGRSKD------------------------T NSQGQLTTS--------------------------------------------------------------- -----------------------------------------------------GTATSVLASDS-QMSK--- ---------------E-------------------------------------------------------- ----------------------------------------------NQR---NNKLETGG------------ --------------------------------------------------LDSGFVNTGFELNGGGL----- ------------------------------------------------------------------------ --------------------------------------DSGFTSDRAS------------------------ -------GIEIS----------------------RMRTTILEF----------------------------- >AgamIR21a/1-975 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----------FSGHR-FTVKAAH------------------------------------------------- ---------------------------------------------------------Q-PP--------FMI --------------------------------------KRL------------------------------- -------------STD-------------G-----------------------VGNVNIRWEGLE-M----- ------------RLLRVMAQ-Y----------------------L----N----------F----------- ------------T----YDIIE-PGR---------TEL-GP----G-------------------------- --------------------------------DA-------------------------------------- --------------------------VVE---EI--------------KR-G--------------Q---GD MGLA-----------------------------------------------------------GIYVT---- -IER--NLAT--------------EM-S-VS-----HSTDC---AAFLT-----------LMSSA------- -------------------------------LPR--------YR------------AILGP---FQ------ ----------------------------------WPV--W-VAV-ILIY------LL-AIFPLAFSDKMTLR HLLGNW------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------S--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------EIEN-----MFWY---VFG--------TFTN-SLTFQG- --------ENSWSNTRKTSTRMLIGI------YWV-----FTIIITACYTG-----SI-----IA-FITLPV E--PE-----------------------RID-----GIEQLSRGFFR------------------VGTLD-- -------------------------RGGWE---------------RWF----L------------------- -------------N----------------------------------SS-HK--------QTNKL------ ----------------LKDL-------------------------------------RFVSSVDE--G---- IRNVTEAF----LI-----------S-Y-A-FIGSKGELEFLIKSNLSH-----------QFENKRYG---- -----LHVSREC-FAL------------------------------------------YG--------VSMV FPPN-S-V-------------------------HRDPINNA-----------ILYMQEAGLIGKLNRDVT-- ---WET-------------MKTK--------------------------------DGRRKEA-SVGEVLRS- --------------------TAPSERGLTLADTEGMFLLML-------------FGYVV-ALG----VLISE WV---------------------------------GGCTN-------------------------------- -------------------KCREV-LKERAERL--------------------------------------- ------------------------KAAAAEIAAAATAGSDNGSLPVSSPT-------------------STN RNSPHKRTGPNGV-------------------------------ENSLPASGN-----------GSATVRRI RLTGEDSEN----------------------------EPNEYDVPPDAASD-GGSSLQRHSLSE-CLSEVSA ---HTMQDLYNGPDRRHSTIVFLD-----------------------------------------------G QLMSE--------------------------------EEAQRKVARS-----KSRHRH-SLS---------- -----------------------------------------------S--VLEREVSQLFRFLG-------- ------------------------------------------------------------------------ ------------------------------------------KESPHSARADES-------SDAGGLVRRGA GRERK--EMKVAVEINARATEEGQQGPGAAVGRRSIEATFGEKLLH-------------------------- >AgamIR25a/1-946 ----------------------------------------------------------------------MD PKN------------------------------------------GR------RWLVLIPIQLASYAI---- ----------------IAIMGQTT-----------------------------------------------Q NINI-------------------------------------------------------------------- -------------------------LFVNEVDN--------------------------------------- ---------------NLANVAVEVAL-----------NYVKKNPQL----------------G-LSVDM--- --MYVEG-NR-TDSKDL--LQALCSKYGQSLSEN--R-PPHLLL---------------------------- ---------------------------------------------------------------------DTT LTGV--------------------SSETVKSFSLALGI-----------------PTVSASFGQEGDLRQWR DLTPTKRGYLLQV---MPPADMIPQ--------VIRSI---IIY-MN------ITNA--------------- -----------------------------A--------ILYD-NTFV------------------------- ---------------------------MD--HKYKALLQNI-----------------------PTRHVVTT IA----------------------DD--RDR-----------ASQIEKLRNLDINN---------------- 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--------------------SPYS-YQN-------------------------------------------- -----N------------------------------REKY-----------------KND------------ ------------------------------------------------------------------------ ----------------------------------DEKR-EF------------------------------- ---------------------------------NIKE-----CLWF---CMT--------SLT-----PQG- --------GGEA--PKNLSGRLVAAT------WWL-----FGFIIIASYTA-----NL-----AA-FLTVSR L--DT-----------------------PVE-----SLDDLSKQY----------------------KIL-- -----------YAPLN---------GSSAM---------------TYF----Q------------------- -------------RMADIEAKFYEIWKEMSLNDSLTAVERSKLAVWDYPV-SD--------KYTKM------ -WQAMLEA---GL----------------------------------------------PNSLEE--A---- VQRIRNSTSA-----S---------G-F-A-FLGDATDIRY--------------------QVLTNCD---- -----LQMVGEE-FSR-KP-------------------------------------------------YAIA VQQG-S-P-------------------------LKDQFNNA-----------ILMLLNRRELEK-------- ---L---------------KEQWW-------------KN-------------DDVQNKCEKPDDQ------- ------------------------SDGISIQNIGGVFIVIF-------------VGIGM-ACI----TLLFE FW---------------------------------YY-KY-------R-NNS-------------------- ------------------------------------------------------------------------ ------------------------------------KVID-VAESTD------------------------Q QHGGTIVKN--------------------------------------------------------------- -----------------------------------------------------VRPAGKLMKQD-SLK---- -----------DSTKG-------------------------------------------------------- -------------------------------------------HNYQNL---RTRTLMP------------- ---------------------------------------------------NLSKFQPRF------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AgamIR31a/1-492 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------M----------NN---------------T------------------ --------VSWLLLSRN------------------------------------------------------- ------------------------------------------------------------------------ -TTADLLPR--------------------VLWNT-------------------------------------- ---AGIQ--MN-SDLVTAI----------------------------------------------------- ------------------------------------------------------------------------ ---E--------------------------------------------TTDH-------------------- -----------------------------------------------R-GV--------------------- ---------------------FN--LFDIYSKGRHL----------------------------CKD----I FQTLLGTW--------------------------------------------------SADGGF-------- ------------------------------------------------------------------------ -------------------------------------R-L------TPNY-SPY--KIRQN----------- 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------------------------LARLSADER--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------NTR---------------------------------- ---------------------------------ATMA-----YVLD---VMA--------CVA-----QQGV ---------PN-V-SRLVPTRVAVIV------LLV-----ANLVLYNYYTS-----TV-----VSGLLSSQM ---I------------------------GPE-----TIAQVIDSPLL------------------------- -----------LSLT----------DTGYHR--------------ILL----R------------------- -------------E----------------------------------QT-LP--------YSTRM------ -HER-KAL---PPR-SPNDL-----------------------------P--------LFTDVEH--A---- VPYLR----------R-G-------G-H-V-LHCELTEVYPAIANQFTA--------------NEICELRT- -----VEGLYRYDIRV----------------------------------------------------MAFV LPKH-S-M-------------------------YSELFKI-----------TLMRAQETGIVKR-------I YRIHKI-------------------------------AKP-----------------ICQG----------- --------------------SATV-YSVELTEVSLAFIIL-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AgamIR40a/1-779 ------------------------------------------------------MGVGS-----NSKYILAL -------------------------------------------------------VLLRVALV--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------W----------------------------------------------------------- --------------------------------------------------------------GAF------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------PTQRNLIAL------------------------------- --------------YERSNQSGMIRG----ISEMVNLLAP-------------------------------- ------------------------KSLVIL--------VQNE-TKIDR------------------------ ---------------------------LD--KLTVMIHHH------------------------NIPTCVYY ------------------------------------------------------------------------ ----DLEAYFS------LIEENLKKSLE-------------------------------------------- ---------------------ITSLI------FCHPED---------MLQDITDR---RLAHR--------- -------LSLFIFY----------------------------------WGA--------------------- ------------------------------------------------------------------------ ------------------------AQLPPTLNPN--------LL---------------------------- ---------MEPFRVAIIT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------NPRRNIF-------------------- ----------------------RIFYNQ-------------------------------------AKPNNRG DMLSVNWF---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------DGNDMTFKRVP-----L------LPSP-TEV----YKN----------- 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------------------QTVHARNARWRPTRSRLRK----------------------------------- -----PAFY---------------------------NLRYIEEMSYTRFRAERT-SLINNHHHSRGQ----- ------------------------------------------------------------------------ ---------------------------------DYPS----------------------------------- ----------------------------------LDR-----CIWY---TIN--------VYL-----RQS- --------A-NIP-FDGHLARFFSIL------LWLC----ATYVLGDVYSA-----QL-----TS-QLARPA R--ES-----------------------PIN-----TLGRLENRMNR-------------------EGYQ-- -----------LLVER---------QSAFH---------------AAL----V------------------- ------------------------------------------------NS-TG--------VLQRL------ -YRLTRQRSVND--------------------------------------------SFLVKSVEE--G---- IRVLQ----------A-D------PK-Y-A-VFGGRETLYFNTKRYGANR---------------------- -----FQLSE--KLYTRYS--------------------------------------------------AVA VQIG-C-P-------------------------FLDSLNEV-----------IMRLFEAGIVEK-------- -----------------ITIAEYEQMFGRQKGGVSHAEET---------------VRTVKSTNSECDTD--- -------G-TGSGKRKTDSNDK--LQPMNLRMLQGAFLVLA-------------CGHLL-GGI----CLFIE ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------RHMGMINPCGDTLRQGW- ------------------------------------------------------------------------ -----------------------------------------------------RHLNRV--------VRK-- -----------------------------------------------LG--RGGSFKTQSN----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AgamIR41a/1-637 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------M------------------------------------------------------- ------------------------------------------------------------------------ ------------------------NYSVELSELTQGELFHF------------------------------- ------------------ELNRLLKW---IFLQHLVSFFC-------------------------------- ------------------------------------TCIVVRTGSSGHWTAATEQFP--------------- -----------------------------------------------------------------HPVMVVA LSRNDELD-----------------------------------VLLDAIE------NGC------------- 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-------------TQ--KFNPNKVH----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------RVDAC-------------ES--------------- -------------------------------------------IMA---IIS--------IFI-----LQSV L-------IRTTR-NPYCSQMILIGS------ILF-----VGLMIGNAYSG-----GL-----AS-VMTVPR F--EK-----------------------SID-----TVQDLADR-----------------------NLR-- -----------WGSTHD----------------------------AWIFSI-Q------------------- -------------L----------------------------------AT-QPT-------IV-KL----LE SFVTYPKDV----------------------------------------------LHEHAKQRNL--A--YS IERLP-------Y----G-------H-Y-A---------------------------VGDYITDVVSS---- N----FEIMLEDIYWE----------------------------------------------------NCVA MATK-TWP-------------------------LMDELDEL-----------TLRIFQSGIQRY-------- 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------------------------------------------------------------------------ -----------------------------------------------------MLLVQLVGAMLLALLPS-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------SVNGIVYVRIRNERG---------PTAARAGIQ-------- ------------------------------CLELLSHTYFN---MRE------TTQIE-------------- ------------------------------------NIVIFYLQNL-------------------------- -------------------SSPA-----R--EILLGYLQLHH--------TGYDIHEDDDDDEDGEPESQFQ ---------------------------------------------LKLMSDS-------------------- ---------VS------------SDDLR-------------------------------------------- ---------------------RAQFM---------DHKQI-----DYYVIVIDSFE--GLQSALDRISA--- TAAFNPR-GKFVVLYNN-------------------------------------------PNDRDSNARLA- ------------------------------------------------------------------------ ------------------------NRALGHLFVG-------------------------------------- ---------HHSVNVLFAF-------------------------------------------A--------- ----------------------------------------I------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------DATSYHVYTGDPYHGA---------------------------------TDCGQM KALKVATV---------------------------------------------------------------- -----------------------------------------------------------------------V NG-----------------------------------S---------------------------------- 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-----------------------------------------------------------YL----------- ------------------------------------------------------------P----------- ------------------------------------------------------------------------ --------------------------------ELAAHR---------------------------------- ---------------------------------ELSM-----CFLN---TWS--------VFL--CISANN- ------R-------PECNALRLLFMG------LTL-----YALNVTTIYTS-----IL-----IT-MLTNPP L--AY-----------------------QMD-----TIEEILASGVP------------------------- ------------------------IGGRLDSE-------------DWF----I------------------- ---------------------------------------------------ND--------FADDRLV---- -SEQYNATS------------------------------------------------EFQPSLDN------- LQAVV----------E-GK------R---S-LLMSRLYV-------------------------RNTKYNGL -----VHGLSRDVLVT----------------------------------Q-----------------IEMI MEKG-F-P-------------------------LLPKFNRI-----------LSNLIDMGIMQKL------- ---WND-------FLYNVTILDRI-------------RAH------------RALSEADIIAASP---E--- -------------------------VVLTLDHLQSAFALYG-------------IGMCL-CVV----VFLLE VL---------------------------------SKTRWIGKGR-VVLEKR-------------------- --------------WD-------------------------------------------------------- --------------------------------ELLVRLQLKERTARE------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------MTIRPRK--------------------------------------------------------- ----------------------------------------------------MVRF---------------- ----------------------------------------------------RKVLK--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AgamIR64a/1-991 ------------------------------------------------------MH---------------- -------------------------------------------------------RVRSAMRLMGHKRMMLS -SWI----------------------------------------------------------------AVPA ILLAAVGL---------------------------------------------------------------- ---------------------ACGYAVTSNDY---------------------------------------- ------------------SETVAT-FVF-----------------------------------RFI------ ------RDHKGLKLGIV----FGCDQKLLLIYN-----VLSQLATI-------------------------- ------------------------------------------------------------------------ ----------------------GVRARMVHIGPGPTPDRNEQ------------------------------ ------------------------EH-----ER-FSS-------TLR------QSLEFHQFV---------- --------------------------------------LL-D-MACE-------NAPDVLKQVSRLFIHPNG AGSGLDRLPAHA-------------------------------------------------CHAHVKPSVVG TMW-----------------------------------------------------RVCNTI---------- ------RYCIL------------PIKAS--------------------RY---------------------- -----------------------ELF----------NA---------------S------------------ --------FHWLIIDNHYN-------------SVEVEGNTGE-------NGLFTCPWT--MITNSTENGGTA KPIQSFTNGTEPDGAM-DSDWTASSN-------------GSEATA-----SGHT------------------ -FD--------------------------LLATM-------------------------------------- ----NVS--IN-AEITVAS----------------------------------------------------- ------------------------------------------------------------------------ ---P-------------------------------------------------------------------- ------------------------------------------------TDP--------------------- --------SY---------RGFT--LYDLWNPGFISG----GKL---------------------------- KIEPLGCY--------------------------------------------------SPAEG--------- ------------------------------------------------------------------------ -------------------------LQIPKREST------------------VV--RRR-N----------- ----------MDGLR-LKIMTV-------------------------------------------------- -----------------V---------------------------------------T-QKP---HQ-PFE- ---------------------------------------LYL------------------------------ ------------TTPQ--------------------------------------NTHLDSVHRYN-Y----- ------------GLMGMLKE-F----------------------Y----N----------F----------- ------------T----FVNRR------------TKS-WG-------------------------------- -----------------------------YLRNG---------------K---F------------------ DG------------------------MIG---AL--------------SR-R--------------E---VD LGGS-----------------------------------------------------------PMFFR---- -QER---HRV--V-----------SY-TTRT-----FVER----PCF-------------I-FRH------- --------------------------------PPRNDAVKN---------------PFLLP---FE------ ----------------------------------IIV--W-YLM-VGC-------GS-I---LV-----TVL CFSFFVEDA------------------------------------------GLAGRNVSP------------ ----ETCLNESL-LNR----PKLSPMRRSYWHRET------------------------------------- TGISYNV-----------DEDDDV-----QGSKSASANVQ---------------PDIRSPNAAGSSRQRWK ICHWLYPVDCRQLV------------------------------------PCNSDAAAAAAVGGGDGTLTAR NCHNKTVPANISSTHRFHPGDGNA--GAKCNYKAEKVS---------------------------------- ------------------------------------K-----SILL---FLG--------GVC-----QQGN LANGVFLPRLSEI-PHLSSGRCTSFF------ILL-----FGYLMYQYYSA-----SI-----VGTLLMEQP ---K------------------------SIK-----TLRNLIDSRLT------------------------- -----------LGIE----------DIPYSR--------------DYF----VDCFISMDPAKIVLQKHTRT NQKNRLPHTPNYQR----------------------------------TT-DA--------DSLEL------ -HRT-RIEY-YEPKTGRNE--------------------------------------SNFLAAAD--G---- LQLVR----------E-G-------G-Y-A-FHVAISAAYRIIRLTFSE--------------REICELSE- -----IDMFPV-WSQW----------------------------------------------------MVAI VQKN-S-P-------------------------YRDVITY-----------GLRRLNEAGLMQR-------Q RHVWQE-------------------------------AKP-----------------KCVRQ---------- --------------------IAPTDLIVGLDAVVSAFVLLC-------------GGICL-SVC----VLFVE IL---------------------------------C-HRI-------E------------------------ ------------------------------------------------------------------------ --------------------------------RHRHGCHRREL----------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------WRNRFVM MTKQPSLPAQ--PRRD-------------------------------------------------------- ----------------------------------------------------GTELF--------------- -------------------------------------------------YVE-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AgamIR68a/1-648 ------------------------------------------------------MCK--------------- -----------------------------------------------------TSRLVWILT----AFVLIL G----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------VK-HCANK ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------QLNSATKGNDRKSSQSIHH---------------------------------- ------EEYSTE-----LHLEMLLLE-------LAAK-MD-------------------------------- -----------------------YGHC-YV--------VLFD-EVYE------------------------- --------------------SVLNAAFFR--QIHR------------------------------AARYIV- -----------------------KIEQDEDTFNPRP----SLKCILESTR-----KAGC------------- ------GGYIL------LMAN--GIQM--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------A--------------------- --------------------LYELSTAPF-----------------------------------PMQIKGVF FSKILNFW---------------------------------------------------------------- ------------------------------------------------------------------------ --------Q-----------------GGKFRLAN---STF------FDDK--------TKD----------- ----------LRRQE-MRVVVLE------------------------------------------------- ---------------------------------------------------------H-TP----------- ---------------------------------------AVFK-----S----------------------- -----------ATTSN--------------------------------------------YYGLE-I----- ------------ELLKAISK-A----------------------M----H----------F----------- ------------Q----MVFYE-TSDA---DK---ER-WGR------------------------------- -----------------------------LGGNG---------------T---L------------------ TG------------------------IIK---EM--------------QE-G--------------K---AD FALA-----------------------------------------------------------DLHHT---- -EYN---LGF--M-----------DL-S-VP-----YNTEC---LTF-------------L----------- -------------------------------TPEA-LS-DNSWK------------TLILP---FN------ ----------------------------------GEM--W-AGV-LLS-------LF-A---VG-----FVF YAFSNTL----------------------------------------------------------------- -------------------MLKWLRH---------------------------------------------- -----------------KKPK----------TNMSKSSAY-------------------------------- ------------------------------------------------------------------------ -----------------------------DRNKLKKLR-MIPFKRQPEPW-----HDPLPA----------- -----------NDMFD-----------------TFSD-----CIIY---TYS--------MLL-----LVS- --------L-PRI-PEKWPLRMLTGW------YWV-----YCVLVVVAYRA-----SF-----TA-ILANPI P--RV-----------------------TID-----TLQDLAESSVR-CG---------------------- -------------------------AWGEQ-------------NRLFF----Q------------------- -------------M----------------------------------AQ-DQ--------YSQTI------ ----------------GAKL-------------------------------------EHAPNQNE--A---- VEKVS----------E-G-------L-Y-A-YYENIYSLRQLRS------------TRKSEKARQ------- ----TLHIMQEC-AVH-MP-------------------------------------------------ISIG LGKN-S-P-------------------------LKHQVDLY-----------VRALIEGGLTRK-------- ---W---------------LSDAI-------------EQF-------------------------------- ---------------QSNVEIPPQEAIIDLKKMYAGIVALC-------------FGYVI-ALF----AFVVE KI---------------------------------YW----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----RYYIENNPAFDKYL----H-----------GIVFRGRG----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AgamIR75d/1-649 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------MHSYYDETISHQQEK---------------------------------- RDDREQNRLAVGVYSVLGTLLCYVGHVE-------------------------------------------- ------PKSKHVKSVTV----IRC------------------------------------------------ ------------------------------------------------------------------------ -----------------------------WEAEERYDFFLAAT----------------------------- -----RKGL----------------L-----VKFVDATNIEALIAIH------PNRVS-------------- ------------------------------------------------------------------------ ------------------------QAGL-----------------------------------------LID ASC------------------------------------------------------EIEPI---------- ------SK-LW------------QMDQI-------------------------------------------- ---------------------LNKLL----------YG---------------N------------------ --------LHWLIVEK---------------------------QL---------------PVKRSIDSGP-- ----------------------YSSD---------------------------------------------- -----------------------------QLELLYNE----------------------------------- -RLRPLDVMPY-TNVVLAFLN--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------VSDS--------------------- ---------------------WE--LFELYKPYRKAR----LSV---------------------------V NI-----------------------------------------------------------ASN-------- ------------------------------------------------------------------------ ----------------------YLPAVDRYGSQLIVRR-------------KLV--DRRRN----------- ----------LQGFA-MPCGTA-------------------------------------------------- -----------------T---------------------------------------T-SP-------EYF- ---------------------------------------TGM------------------------------ ------------DDRN--------------------------------------DV-HDLFTKAN-F----- ------------PFIRELMY-D----------------------L----N----------F----------- ------------T----LNMVQ------------LDK-VGYKQ----------------------------- --------------------------------NG---------------T---F------------------ SG------------------------VMG---KF--------------QN-R--------------S---IE LGCL-----------------------------------------------------------GTLMR---- -TER---LEV--A-----------DF-MIVT-----LIIK----SSI-------------I-FRQ------- --------------------------------PPLSIV-AN---------------IFELP---FS------ ----------------------------------VGV--W-ACC-FAL-------MA-I---YW-----MTM IAIRQLTSGERF------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------G------------------------------------------ ------------------------------------------------------------------------ ----------------------------------AIE-----SLVY---IIG--------TMC-----QRG- ---------CDIV-PQFNGTRLLMFS------LQL-----TSFFILTSYSA-----SI-----VA-LLQSPS ---R------------------------AIA-----SVGDLVRSPLK------------------------- -----------AGVM----------DTSYGR--------------VYY----Q------------------- -------------E----------------------------------TQ-DP--------DVQEL------ -YRK-KIK-----------------------------------------PHGE----KAFLEPNE--G---- IGRVK----------Q-E-------M-Y-A-YEGELNAAYKLIKETFAP--------------EEVCKLQE- -----LEAIK---LPP----------------------------------------------------FGIP IVKG-S-K-------------------------YRELIRQ-----------RLMWQREVGIIKR-------F NLIWIH-------------------------------QKP-----------------QCEN----------- --------------------LNAGFSSVGVVEMRYLYLFLA-------------VGFLA-ALA----TLLAE RS---------------------------------WWSGM-------A-KKLK------------------- ------------------------------------------------------------------------ --------------------------------SRTAIIRRK------------------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------NEA-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AgamIR75g/1-579 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------MT---------------------------------------- ------------------KEAVES------------------------------------------------ -------TRK--QTRII----LHKVLI-------------HQL-H--------------------------- ------------------------------------------------------------------------ --------------------------SAMKNHPASMSFLNVA------------------------------ -------SFSGS------------KF-----EASLQSLHVGV------------------------------ ------------------------------------------------------------------------ -------------------------GL------------------------------------------MAD L--------------------------------------------------------NCDGL---------- ------AG-VL------------KA-LS--------------------VR---------------------- -----------------------GFF----------NG---------------AR----------------- --------FRWLL-GGL---------------------------G---------------TLQQSRM----- ------------------------------------------------------------------------ -----------------------------FLEKL-------------------------------------- ----NIT--AS-SMVLLTL----------------------------------------------------- ------------------------------------------------------------------------ ---P--------------------------------------------MRTS-------------------- -----------------------------------------------NNDT--------------------- --------N------------FA--ILDVCGHRVGTR----WEL---------------------------- SFLQIGAW--------------------------------------------------STSAG--------- ------------------------------------------------------------------------ -------------------------LTMWDKRSV------------------Y---ERRQN----------- ----------LLGMQ-LTGIAK-------------------------------------------------- -----------------A---------------------------------------T-AI----GASTVT- ---------------------------------------GEL------------------------------ ------------QS----------------------------------------------GRAYG-L----- ------------RLWNVLST-M----------------------H----N----------L----------- ------------S----I------------------------------------------------------ -----------------------------------------------------T------------------ EN------------------------PVN---EG--------------NQ-Q--------------P---FD LIIN-----------------------------------------------------------PVEIK---- -QQD---ISK--L-----------HY-TAAV-----HDTQYVSLTIL-------------L-FLH------- --------------------------------PNVDWT-RN---------------LFLRP---FT------ ----------------------------------VLS--W-LGI-TAL-------FL-A---FL-----LLM CCILHLDRLEG------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------QDREN---------------------------------- ------------------------------------G-----ILVL---VLG--------ILC-----QQG- ---------FIET-FHSYASRITVFA------MIL-----FSMLVYQFYLT-----YI-----VSFLLVVPP ---K------------------------TIH-----TLHQLVENGFA------------------------- -----------VALE----------NVPKNV--------------EYL----N------------------- -------------A----------------------------------TD-DE--------HLLAL------ -VQK-QLT--------QAD--------------------------------------TLYYDMAE--G---- LELIL----------R-G-------R-V-A-FLCDAHHAYQMMQTHFTD--------------EQRCALQE- -----VVLIS---KKS----------------------------------------------------THLA LAKD-N-P-------------------------LRELFRV-----------TVHRIAGNGVMQY-------E RSRCYA-------------------------------DKP-----------------RCAEN---------- --------------------EVKMP-EVNLDQVSSVMVLLL-------------GAIVG-SIA----VLLLE LT---------------------------------H-SRV-------W-P---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------RRHRVV- ------------PSRGI------------------------------------------------------- ----------------------------------------------------NRKL---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AgamIR75k/1-675 ---------------------------------------------------MDKSRYLQF------------ -----------------------------------------------------LVQSLIVLKVL-------- ------------------------------------------------------------------------ --TVSNGT---------------------------------------------------------------- ---------------------PQATAVNPLSPQTQT------------------------------------ ------------------DQRIAA-VRD-----------------------------------LLV------ ------HLDRAHQLLV-----LTC------------------------------------------------ ------------------------------------------------------------------------ -----------------------------WSPSVRYALWQ-------------------------------- ------------------S------------VRESTATSHRGTASVR------FAPIDQRHL---------- --------------------------------------PW-----------HDPNQ---------------- -----------------------HQIVI-----------------------------------------VLD LS--------------------------------------------------------CPGT---------- ------DR-LL------------ES-AR--------------------Q----------------------- ------------------------LL----------YY---------------R------------------ --------VRWIVFRSSIEES-----------------------G---------------GSVRGWS----- ------------------------------------------------------------------------ --NCSEY-S--------------------VLDRL-------------------------------------- ----PLL--VS-NELFYFC----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------TETST-------------------- --------GQ-----------HL--VRQQYRLAARSA----SSSV--------------------------P IYETFGTW--------------------------------------------------NAALG--------- ------------------------------------------VRVVVDSK---------------------- -----------------------------VRPPV------------------TS--IRRQN----------- ----------FHKFQ-LRASLV-------------------------------------------------- -----------------I---------------------------------------L-HN-------ETL- ---------------------------------------NHL------------------------------ ------------DDLH--------------------------------------DKHIDTLSRVN-Y----- ------------LLTKSVAH-A----------------------L----N----------A----------- ------------T----VKFSI------------VDT-WGYRD----------------------------- ------------------------------RETD---------------R---Y------------------ NG------------------------MIG---EL--------------QR-D--------------L---AD LGGT-----------------------------------------------------------SMFFT---- -QDR---IKS--V-----------DF-LAMT-----ASTR----ASF-------------I-FRA------- --------------------------------PKLSFT-SN---------------VFVLP---FD------ ----------------------------------QYV--W-YCT-VSF-------IV-L---SG-----VLL LVMLRTEQ---------------------------------------------------------------- --------------------------RY-------------------------------------------- ----------------TAGGRGG-------------RGSA---------------IGSNSPAAVT------- ------------------------------------------------------------------------ -------------------------------------G---------------------------------- ----------------------------------LSD-----TLLN---VFG--------TTC-----QQG- ---------SFIE-PQTAPSRCLILL------CLV-----VLMFLYASYSA-----NI-----VA-LIQAPS ---T------------------------KIQ-----TLEDLLASRLK------------------------- -----------TGAE----------DTVYNQ--------------YYF----R------------------- -------------T----------------------------------ET-EP--------SRKAL------ -YER-KMR----NKDGT----------------------------------------ENFLPLAQ--G---- VELIR----------Q-G-------H-Y-A-FHVERGVCYKLISETFQE--------------EEKCGLQE- -----VEYLK---VIE----------------------------------------------------PYYA IQKN-S-S-------------------------FREPVRI-----------NLFKLREFGIQGR-------E HTLLYT-------------------------------KKP-----------------RCI------------ --------------------GGSSFIPVSIVDVWPALVTLG-------------WGYLL-TVA----VLIAE LL---------------------------------W-FRL-------R-SRIL------------------- ------------------------------------------------------------------------ -------------------------------------PTAG------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------YFQ---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AgamIR75l/1-669 ------------------------------------------------MGGRDK----QD------------ -----------------------------------------------------LILPLMIAPL--------- ------------------------------------------------------------------------ ---LLSGY---------------------------------------------------------------- ---------------------SVAAAVDA------------------------------------------- -------------------SMVGA-VGA-----------------------------------LLK------ ------LIGTPLKVTAF----VEC------------------------------------------------ ------------------------------------------------------------------------ -----------------------------WNEGEKLMFAR-------------------------------- ------------------IGL---SG-----GRHLMQFV----EPRR------ASPDARTDV---------- --------------------------------------KDMD-NYRNATLDEDAES---------------- -----------------------HQTLV-----------------------------------------VVD LR--------------------------------------------------------CNGS---------- ------ER-LL------------AE-AG--------------------Q----------------------- ------------------------RL----------YL---------------N------------------ --------YRWLLMD--FSEG-----------------------G---------------AP-L-------- ------------------------------------------------------------------------ --GIEHYLA--------------------VLQDL-------------------------------------- ----PAL--VS-SEIFVML----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------EEDG--------------------- --------QS-----------IR--FMQVYRVSQNSE----LLT---------------------------- --EHYALW--------------------------------------------------NATVPGD------- ------------------------------------------TEGEMIDL---------------------- -----------------------------RTHKV------------------TS--VRRKD----------- ----------LHGHY-LRASMV-------------------------------------------------- -----------------I---------------------------------------T-NP-------DTL- ---------------------------------------NHL------------------------------ ------------TDYK--------------------------------------DKHIDTITKVN-Y----- ------------ILTNCLVA-Y----------------------L----G----------A----------- ------------E----VNYTR------------VAT-WGYYN----------------------------- ------------------------------TTTG---------------M---W------------------ DG------------------------MIG---EL--------------VH-N--------------T---AD LGAS-----------------------------------------------------------PLFFT---- -TDR---IAV--I-----------EY-LAMT-----SETR----SKF-------------I-FRS------- --------------------------------PKLSYT-EN---------------VFVLP---FD------ ----------------------------------DKV--W-ICV-IAV-------II-V---SS-----VLL LVTLWAEW---------------------------------------------------------------- --------------------------RI-------------------------------------------- ----------------TNGDLDM----------------------------------PPAPPDSS------- ------------------------------------------------------------------------ ---------------------------------TMAAS---------------------------------- ----------------------------------LRD-----TLLM---MYG--------ASC-----QQG- ---------SAVL-PRSCSARTITML------TFT-----VLMFLYASYSA-----NI-----VA-LLQSPS ---T------------------------KIQ-----TLEDLLASRLK------------------------- -----------FGVH----------DTVFNR--------------HYF----T------------------- -------------H----------------------------------AT-EP--------TRRAL------ -YEQ-KIR----RPYGP----------------------------------------DAFIALEQ--G---- IDRIR----------H-G-------L-Y-A-FHVEQGVGYKVISETYQE--------------DEKCGLQE- -----IQYLQ---VID----------------------------------------------------PYYA IQKN-S-S-------------------------YKEMVKI-----------GLFRLNEHGIQYR-------E NDKLYT-------------------------------KKP-----------------TCSG----------- --------------------GGGKFVPVSLVDVEPAVWIIL-------------WGSGL-ASG----FFLTE RL---------------------------------Y-FRF-------L-RRK-------------------- ------------------------------------------------------------------------ --------------------------------------VRQ------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------LVRR--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------WQHN------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AgamIR76b/1-658 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------MDRFPVMMM--MMVRFVKPCARSYALC----------------RAERWPDKD HGDPQRRRY----------------GMTAT------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------V----------------------------------------- ---------AVALAMMMMI----VVATTQLGVDAQG------------------------------------ ------------------------------------------------------------------------ ------IAPVEW-----------------------------------------DG----------------- -----------------------------------------------NETTEY------------------- ------------------------YQLEM-------------------------------------DASAEV KEREMQEL---------------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------------RRR----------- ----------LAGTT-LRVTTLQ------------------------------------------------- ---------------------------------------------------------D-WP--------LSY -----------------------------------------T------------------------------ -----------VKI-N-------------GTY---------------------------IGAGVA-F----- ------------ELLEFLME-K----------------------F----N----------F----------- ------------T----YELVM-PEQ---------NI-VGSS------------------------------ -----------------------------NDMAG-------------------------------------- -S------------------------VLQ---LL--------------TN-G--------------T---AD MAVS-----------------------------------------------------------FLPIL---- -ADA---RQH--I-----------RY-S-TG-----LDEGE---WIM-------------I-MVR------- --------------------------------PME-SA--SGS-------------GLLAP---FN------ ----------------------------------RDV--W-ILI-LVS-------LL-A---VG-----PII YGLLIL------------------------------------------------------------------ --------------------RHRL-T---------------------------------------------- -----------------------------------------------------------KD----------- ------------------------------------------------------------------------ ----------------------------------KEQI-IY------------------------------- ---------------------------------TLPH-----CVWF---VYG--------ALM-----KQG- --------S-TLS-PTGDSTRILFAS------WWI-----FITILTSFYTA-----NL-----TA-FLTLSK F--TL-----------------------PIN-----NAEDVRR-----------------------KEKQ-- -----------FVTIR---------GGAIE---------------YAI------------------------ -------------K----------------------------------NR-DE--------ALNAL------ -SVLVDKR---LVD--------------------------------------------FTTNVND--S---- DTLAD-------KVAK-Q-------N-Y-V-FVRDRPAIDHMIYADYLVRR-----KINPKNERVHCP---- -----YATATTP-FLK-RN-------------------------------------------------RAFG YPPN-T-E-------------------------WNRIFDPE-----------LLKMVEGGIVKY-------- ---K---------------LHDRL-------------PK-------------A---EICPQNLGG------- -----------------------TERQLKNRDLVMTYFVMV-------------TGFVT-SIV----VFASE LG---------------------------------F--RY-------L-N---------------------- --------------------QR-------------------------------------------------- ------------------------------------KLNEQLAQQQQQQQQQDQ-------------QPTSK KLATERI---------------------------------------------SYL----------------- -----------------------------------------------------GKQFTTG------------ --------DSPPPPYAEVFSRHQQ-------------QQQLGVLG--------------------------- ------------DSERTGKLFD-----DGSGGLFGA---GAGGANRQMI---NGRDYM-------------- ------------------------------------------------------VVREKNGLGSRLI----- ------------------------------------------------------------------------ ----------------------------------------PMRAPS-------------------------- ------------------------------------AAIFHYTYAN-------------------------- >AgamIR8a/1-891 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------MVGNVMKKVM-----------ANANG----------------------ISIK---- --EYYIQYDHEFAPFGE--DEQFCAAMF--------E-GVSVLL---------------------------- ---------------------------------------------------------------------DTT WID----------------------SRYLASAAEEFGI-----------------PYFHIDLS--------- -------------------VQTYVK--------LLESF---LLA-RG------GNDV--------------- -----------------------------V--------YILP-NYQD------------------------- ---------------------------AD--ATIYLLITDS-----------------------YLRAIVFG -------------------------ELDGDT-----------VDRIKDLRPYP-SF---------------- --------YAV-------IAG--TMEMN-------------------------------------------- -----------------------TIL-----------QKA------------IDG---GLVR---------- ----KPE--KWNLL----------------------------------------------FTDLQT------ ---DKYTLGDDFPQMN----RLVLDSNTCCIL-LQQRFPCI---------CPDP------------------ ------------------------------F----------------------------------------- -----------DPMDAHLQ----N--------------------------------VLERI-V--------- ----QWFIKD--------------------------------------------PIPLVRASNCT------- ----------PESQQQELLEH---------------------------AIAAQ------------------- -TKLMNEIAAMAEFW------------------------------ITLESGMLR------------------ -------------------PNLNLSIISQPANQNTT------SAA-----------------------AQPP PATTIGNV--------------------------------------------------AKGQ---------- ------------------------------------------------------------------------ ---------------------------IVLVKNE------------------------SLK----------- ----------PSKRF-FRVGTTE------------------------------------------------- ---------------------------------------------------------S-IP--------WAY ------------------------------------------R-----KRDPN------------------- ------GNILRNST-T-------------GE---------------------------PIWEGYC-I----- ------------DFLHQLSV-V----------------------M----N----------F----------- ------------D----YDLVS-PRN---------GT-FGL------------------------------- -----------------------------RDADG---------------K---W------------------ DG------------------------LVG---DL--------------VV-G--------------E---ID FAIA-----------------------------------------------------------SLKMT---- -AER---EEV--V-----------DF-V-APY----FEQTG---ILI-------------A-MRK------- --------------------------------PVR-ET--SLFK-------------FMTV---LR------ ----------------------------------LEV--W-LSI-LLA-------IV-A---TA-----VML WLLDKF------------------------------------------------------------------ --------------------SPYS-AKN-------------------------------------------- -----N------------------------------KDAY-----------------P-------------- ------------------------------------------------------------------------ ----------------------------------YECR-KF------------------------------- ---------------------------------TLKE-----SFWF---ALT--------SFT-----PQG- --------GGEA--PKALSGRTLVAA------YWL-----FVVLMLATFTA-----NL-----AA-FLTVER M--QT-----------------------PVQ-----SLEQLSRQS----------------------RIK-- -----------YTVVK---------DSDTH---------------DYF----R------------------- -------------NMKNAEDVLYQMWRNLTLS---SGNDQAQYRVWDYPI-KE--------QYINI------ -LSAIESA---NP----------------------------------------------VATAAE--G---- FRRVNERLDA-----D-----------F-A-FIHDSAEIRY--------------------EISRNCN---- -----FTEVGEV-FAE-QP-------------------------------------------------YGIA VQQG-S-H-------------------------LQDELSYF-----------ILELQKERYFES-------- ---L---------------TAKFW-------------NN-------------S-ARSQCPNTDD-------- ------------------------SEGITLESLGGVFIATL-------------VGLAL-AMI----TLLGE VI---------------------------------YY-RR-------K-E-TSR------------------ ------------------------------------------------------------------------ -----------------------------------NFIKV---APFGNAD-------------------KPM ARDGKRIAL--------------------------------------------------------------- -----------------------------------------------------KQK-SIAAVKH-LLD---- ---------LDTPAKA-------------------------------------------------------- --------------------------------------LRGATTTVKIN---TKKEKPIP------------ ---------------------------------------------------KEITIGNKFVSAAE------- ------------------------------------------------------------------------ ------------------------------------------KQQKLS------------------------ -------YIAIM----------------------PRN-AIH------------------------------- >AgamIR93a/1-885 -----------MVLR--------------------------------------LVG---------------- -----------------------------------------------L-WSI-LLLLLLLLVLRPDPAV--- ------------------------------------------------------------------GDDFPS ---LL-----------------------------------------------------------------ST NASMGKL-------NI----TPLLSIILD------------------------------------------- -REYLGAD--YERTLDETKNVVEKLI-------REH---LKN--------------------GGLIVKYYSW --TSI-NLKR-DFSAVL--SVSSCKNTWDIYQEAVRE---RLVMLSITD----------------------- --------------------------------------------------------------------PDCP R----------------------------LPTNNAIMI-----------------PRSDGSGSNA------- -------------------FDEVSQ--------IILDMK--SSRAIN------WHTAT-------------- --------------------------------------LLYD-QVY-------------------------- -----------------------DAEI-S--RCILSLLE--DREGIK-----------------PLTLTEFK INAPT----------------HSW-EKRKEI-----------RRTLLGI--PTAY--TG------------- ------RNFIA-------IVN--IATLT-------------------------------------------- -----------------------LLM-----------EIS------------KDL---KLVN---------- -----PF-AQWLYL----------------------------------------------IPNTEKA----- ------------------------------------------------------------------------ ----NSNFTTR----------------STLI----------------------------------------- ---------NEGDNVAFVY----NSGSKAQ--NCTVSVL-----------CYIES-YLLHF-I--------- ----RSLSKLIREEQVVFGQISDE------------------------------------------------ -EWE-IIRPSKQERKTKFLQM---------------------------IKAAI------------------- -----------------------------------------------TSKDECN------------------ -----------------KCSQWKIQSAETWGYVYR--------TDFL-------------TDGADLQERRKY TMLDIGYW-----------------------------------------------------SPQDG------ --------------------------------------------FMLTDA---------------------- ---------------------------------------L------FPHT--------QYG----------- ----------FRGVQ-LIFYSYH------------------------------------------------- ---------------------------------------------------------N-PP--------WQF -----------------------------------------VA----------------------------- -----------YND-S-------------GSP--------------------------VISSGVV-Y----- ------------DILNELSR-K----------------------L----N----------F----------- ------------T----YTMVI-------------------------------------------------- -----------------------------SQP-A---------------E---I------------------ NGSLVE-GNTSSVYDLKTISSDIPQEIFS---TL--------------VN-N--------------K---IL LAAV-----------------------------------------------------------GATVN---- -EKQ---KKF--V-----------SF-T-DP-----ISIQT---YSF-------------V-ISR------- --------------------------------PRE-LS--RVL-------------LFLSP---FG------ ----------------------------------SDT--W-LCL-AAA-------VA-L---MG-----PIL CAINKL------------------------------------------------------------------ --------------------SPYY-E---------------------------------------------- ---------------------------------------V-----------------HNKP----------- ------------------------------------------------------------------------ ----------------------------------TDTG-LG------------------------------- ---------------------------------KVNN-----CFWY---IYG--------ALL-----QQ-- --------G-LYL-PYADSGRIIIGT------WWL-----VVLVIVTTYCG-----NL-----VA-FLTFPK I--DI-----------------------PVN-----RVMQLLRND---------------------RGMT-- -----------WSIRR---------GTFLE---------------EML----M------------------- -------------D----------------------------------ST-EP--------KYMQL------ -YKGSQII---GE------------------------------------------------LTDE--L---- VERIE----------A-G-------Q-H-V-HIDWRNNLRYLMKRQFLR--------------TDRCD---- -----FALSTDE-FLD-EQ-------------------------------------------------IALV MPKD-S-P-------------------------YLELVNEE-----------IKRMHQFGFIQR-------- ---W---------------VAQYL-------------PA-------------K---DKCSGTGRVM-D---- ----------------------VQNHTVNSSDMAGSYWILL-------------LGFVS-GLF----VFVCE FA---------------------------------VA----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------WYR--------------------------- ------------------------------------------------------KHRA-------------- ---------------------------------------------------ARAATV--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------A--YRD------------------------------ >AgamNMDAR1/1-966 ------------------------------------------------------MK--------LTRML--- PAS------------------------------------------C-----------MLLSLMIP------- ----------------QALLAQKP-----------------------------------------TGSESPS YYNIG------------------------------------------------------------------- -------------------------GVLSNNE---------------------------------------- -----------------SESHFATVI-----------AHLNFDQQY------------------VPRGTT-- --YYDKTIRIDKNPIKT--ALNVCKHLI--------SRRVYAVVVS-------------------------- --------------------------------------------------------------------HEPT -GDL--------------------SPAAVSYTSGFYQI-----------------PVIGISSR--------- EAAFSDKNIHVSFLRTVPPYYHQAD--------VWLEI---LSH-FG------YTKV--------------- -----------------------------I--------IIHS-SDTD------------------------- --------------------GRAVLGRFQ--TTSQTNYDDI-----------------------DVRATVES IVE--------------------FEPKLDSF-----------SSYLMDMKTAQSRV---------------- --------YLL-------YAS--QEDAY-------------------------------------------- -----------------------VIF-----------RDA------------AIH---NMTE---------- ----YGH--IWIVT----------------------------------------------EQALSA------ ------NNTPT------GIIGLKL------------------------------------------------ ----------------------------NNA----------------------------------------- -----------ENETDHIK----D--------------------------------AIYIL-A--------- ----SAIK--EMTVNE---------------------------------------TITEAPKDCD------- ------DSGVIWESGKRLFGY---------------------------LKTRNIR----------------- -------GETGQVAFDDNGD---------------------------------------------------- ------------------RMYAEYDVINVHE--------------------------------KHSFV---- ---KVGSF--------------------------------------------------HYDSE-KRK----- --------------------------------------------MRLKIN-DSSITWPG------------- ----------------------------NTGKKP------------------------EGI----------- ----------MIPTH-LKVLTIE------------------------------------------------- ---------------------------------------------------------E-KP--------FV- ------------------------------------------------------------------------ ---------YARKLLD-------------DEIDC-ADDE----VVCPHFNITNGNEQEYCCKGYC-I----- ------------DLLKALAQ-R----------------------I----N----------F----------- ------------T----YDLAL-SPD---------GQ-FGHYQL---------------------------- -----------------------------KNHTTGIG---TTVKK----E---W------------------ NG------------------------LIG---EL--------------VA-E--------------R---AD LIVA-----------------------------------------------------------PLTIN---- -PER---AEF--I-----------EF-S-KP-----FKYQG---ITI-------------L-EKK------- --------------------------------PSR-SS--TLVS-------------FLQP---FS------ ----------------------------------NTL--W-ILV-MVS-------VH-V---VA-----LVL YLLDRF------------------------------------------------------------------ --------------------SPFGRFKL-------------------------------------------- -----S------------------------------TT---------------------DG----------- ------------------------------------------------------------------------ ----------------------------------TEED-AL------------------------------- ---------------------------------NLSS-----AIWF---AWG--------VLL-----NSG- --------IGEGT-PRSFSARVLGMV------WAG-----FAMIIVASYTA-----NL-----AA-FLVLER P--KT-----------------------KLT-----GINDARLRNT-------------------MENLT-- -----------CATVK---------GSSVD---------------MYF----R------------------- -------------RQVE---------------------------------------------LSNM------ -YRTMEAN---N-----------------------------------------------YDTAEQ--A---- IQDVKD-----------G-------K-LMA-FIWDSSRLEY--------------------EASKDCE---- -----LVTAGEL-FGR-SG-------------------------------------------------YGVG LQKG-S-P-------------------------WTDAVTLA-----------ILDFHESGFMES-------- ---L---------------DKEWI-------------FH-------------GNVQQ-CEQFEKT------- ------------------------PNTLGLKNMAGVFILVG-------------AGIVG-GIG----LIIIE VV---------------------------------YK-KH-------Q-IKKQKKMEIARHAADK------- --------------WRGTIEKR-------------------------------------------------- -----------------------------------KTLRASLAMQRQYNVG------------------LNS V-SK----S--------------------------------------------------------------- -----------------------------------------------------VQSQNAEKSRY-PILP--- -----PL--PRTPE------------RAWP-----------------------KDKEYIVNRKN-------- ------------------------------------------------------NSSGAGKP---------- --------------------------------------------------------PPRYM----------- ------------------------------------------------------------------------ ----------------------------------------PTYATDVS------------------------ -------HLIV------------------------------------------------------------- >AgamNMDAR2/1-1101 MNETYSLCIIILFLSL------------SCN--------------------VALVV--------SKSYKVNS GRSGSGISIGNSHNNAANYGTHGSVSTGSAN--VNTVGFSSSGASGRL-----VINSGITSV---------- ---------------------------------GGG------STSSRLSTNGAP-----------IRNPAEH QLNIG------------------------------------------------------------------- -------------------------LLVPHTNFGR------------------------------------- ---------------REYLRSINSAVQGLQKGRGAKLTFLKD--------------------HEFQTSN--- --IHFDMMSLTPSPTAI--LNTLCKEFL--------HANVTAILYMMNY----------------------- --------------------------------------------------------------------ESYG RSTA--------------------SAQYFLQLAGYLGI-----------------PVISWNADNSG-----L ERRASQSALQLQL---APSIEHQSA--------AMLSI---LER-YK------WHQF--------------- -----------------------------S--------VVTS-QIAG------------------------- ------------------------HDDFV--QAVREQVGAM-D---------------------HFKFTILN SII------------------------VTRP-----------SDLLELV-NSEARV---------------- --------MLL-------YCT--KSEAI-------------------------------------------- -----------------------EIL-----------HAA------------EEL---QITG---------- ----ENY--VWVVT----------------------------------------------QSVIENT----- -Q--------------------------------------------TH------------------------ ----------------------------PQF----------------------------------------- ---------P-IGMLGVHF----DTSSGA---------------------------LVNEI-A--------- ----TAIRVYAYGVEYY----------------LNDVK-------------NTGRRLDTHQLSCE------- -----DQGRGRWDSGEVFFKY---------------------------LRNVSLE----------------- -----SESNKPNIEFTADGD---------------------------------------------------- ------------------LKSAELKIMNLRP-----------SVN-----------------------SKGL VWEEIGIW--------------------------------------------------KSWQQ--QK----- --------------------------------------------LDIR-----DIAWPG------------- ----------------------------NSHTPP------------------------QGV----------- ----------PEKFH-LKITFLE------------------------------------------------- ---------------------------------------------------------E-AP--------YIN -----------------------------------------LS-----PADPVSGKCLMDRGVLCRVAADHE M-TDIDMGQAHKNG-----------------------------------------SFYQCCSGFC-I----- ------------DLLEKFAE-E----------------------L----G----------F----------- ------------T----YELVR-VED---------GK-WGTLE----------------------------- --------------------------------NG---------------K---W------------------ NG------------------------LIH---EL--------------VN-R--------------K---TD MVLT-----------------------------------------------------------SLMIN---- -AER---EAV--V-----------DF-S-EP-----FMETG---IAI-------------VVAKR------- -------------------------------------T--GIISPT----------AFLEP---FD------ ----------------------------------TAS--W-MLVGIFA-------IQ-A---AT-----FMI FLFEWL------------------------------------------------------------------ --------------------SPSG-YDM-------------------------------------------- -----KTV-------------------------LQNGQTT-----------------P-------------- ------------------------------------------------------------------------ -------------------------------------Y-RF------------------------------- ---------------------------------SLFR-----TYWL---VWA--------VLF------QA- --------AVHVDSPRGFTSRFMTNV------WAM-----FAVVFLAIYTA-----NL-----AA-FMITRE E--FH-----------------------EFT-----GLDDSRLSHPF-S---------------HKPTIK-- -----------FGTIP---------WSHTD---------------STI----S------------------- -------------KYFKE--------------------------MHYYM---K--------QYN-------- -----------------------------------------------------------RSSVAD--G---- VTAVLS-----------G-------Q-LDA-FIYDGTVLDYLV------------------QQDEDCR---- -----LLTVGQW-YAM-TG-------------------------------------------------YGLA FSRN-S-K-------------------------YVGMFNKR-----------LLEFRANGDLER-------- ---L---------------RRFWM-------------TG-------------T-----CRPGKQEHKS---- ------------------------SDPLALEQFLSAFLLLM-------------AGILL-AAL----LLLLE HL---------------------------------YF-KY-------F-RKRLAKKD--------------- ---------------------------------------------RGG------------------------ -------------CC--------------------ALISLSMGKSLTFRG---------------------- ------------------------------------------------------------------------ ---------------------------------------------------------AVYEATE-ILRR--- -----H--RCNDPICDTHL------------------------W---------------------------- ----------------------------------------KVKHELDMS---RLRNQHLEKT-MQI------ ------------------------------------------------HGIKPPQPKL-------GSTNKII RIAGTTGA---------------------------------------------------------------- ----------------------RDLIDDGY--QQ------PNLFGNLS---------------IGGSSQDLY RWSYK---TEIA----------------------EMETVL-------------------------------- >AmelIR25a/1-947 ------------------------------------------------------------------------ -------------------------------------------------------------MTGAGFN---- ----------------EKYMSAPP-----------------------------------------------R KLRYR------------------------------------------------------------------- -------------------------VIINDEAN--------------------------------------- ---------------KVANQSITTAL-----------ETIKENYPN-------------------HLGN--- --VWSVQVNE-SDINNT--LDRVCNNWDSAVEKGGAE-VPDLVI---------------------------- ---------------------------------------------------------------------DTT TAGL--------------------AAKISNSFTAALGI-----------------PTLSAQYGQVGDLQYWR KLSADQQDYLIQV---MPPTDLIPE--------VIRQL---SIQ-LN------ITNA--------------- -----------------------------A--------ILYD-YNFV------------------------- ---------------------------MD--HKYKSLLLNV-----------------------PTRHVINE TS----------------------QQ-IIEM-----------KRQLLRLRDLDIVN---------------- --------YFI-------LGN--ENTIS-------------------------------------------- -----------------------IAL-----------EAA------------DAL---NFTD---------- ----KKY--GWFLL----------------------------------------------TPD--------- ---------------------------------INIWPRCE---------CRDISVLFMKPEFD-------- ----KRNNSD----SVEFSLP-K-----PIL----------------------------------------- -------------LSAFYY----D--------------------------MIRL--AVLAM-K--------- ----SALDDGE-------------------------------------------WPMEPRHITCD------- -EYN-NTNTPERK--LNFFGK---------------------------LKDAY------------------- ---KNITPTYAGIKW---G--------------------------SRNGEHQAK------------------ -------------------FVMSVHLVTIKD-------------------------------------GVVS NTVDSGSW--------------------------------------------------NASIS--SP----- --------------------------------------------LQL------------------------- -----------------------------TNNDV------------------------MNT----------- ----------TAVKS-YRVVTVI------------------------------------------------- ---------------------------------------------------------H-PP--------FVM ------------------------------------------Y-----N----------------------- ---------EEKNE----------------------------------------------YYGFC-I----- ------------DLLNEIKK-T----------------------V----G----------F----------- ------------Q----YEIRE-TDD---------KK-YGS------------------------------- -----------------------------LNLDG---------------S---W------------------ DG------------------------MMR---EL--------------IE-K--------------R---AD IALG-----------------------------------------------------------SLWVT---- -AER---ERV--V-----------DF-T-VPY----YDLVG---LSI-------------M-MLK------- --------------------------------TKT-TT--SLFK-------------FLTV---LE------ ----------------------------------NEV--W-FCI-LAA-------YL-F---TS-----VLL WIFDRW------------------------------------------------------------------ --------------------SPYS-YQN-------------------------------------------- -----N------------------------------REKY-----------------KND------------ ------------------------------------------------------------------------ ----------------------------------DEKR-EF------------------------------- ---------------------------------NLRE-----CFWF---CMT--------SLT-----PQG- --------GGEA--PKNLSGRLVAAT------WWL-----FGFIIIASYTA-----NL-----AA-FLTVSR L--EI-----------------------PIE-----TLEDLSKQY----------------------KIQ-- -----------YAPVI---------NSSAY---------------IYF----K------------------- -------------RMANIEWKFYEIWKEMSLNDSLSDVERANLAVWDYPV-SD--------KYTKM------ -LQAMEEA---GF----------------------------------------------PASTEE--A---- LRRVRRLDSN-----N---------E-F-A-YIEDSTTIKY--------------------LTMTNCD---- -----LIQVGED-FSR-KP-------------------------------------------------YAIA VQRG-S-P-------------------------LKDQFNNA-----------ILILLNKRKLEK-------- ---L---------------KDKWW-------------KK-------------NPNKKDCDAENSQ------- ------------------------SDGISIHNIGGVFVVIF-------------LGIIF-ACF----TLAFE YW---------------------------------YY-RH-------R-NAQ-------------------- ------------------------------------------------------------------------ ---------------------------------------D-TASIWAAP--------------------TLS IPSGPLWPT--------------------------------------------------------------- -----------------------------------------------------DTTETIFTLST-SLYG--- -------YATDTPYQESIVDD-------SPLIP----------W-----DI--------------------- DLISI-------EDYA------------------------------DEY---SNKNKSG------------- ---------------------------------------------------DRSDM---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AmelIR68a/1-547 ------------------------------------------------------------------------ -------------------------------------------------------MLLVTLFLQFIVLASS- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------KRVLY---------------------------------- ------KLHQCEN--NEANLKSLAEE-------IVEEIIE-------------------------------- -----------------------QTNC-II--------FITD-STYQ------------------------- --------------------NLIDIKNIK--GSSN------------------------------VSKYETN -----------------------LIRKSHK------------------------------------------ ------------------------------------------------------------------------ ------------------------LK-----------RYC------------ETT---SI------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------ILIAVFE------------------------------------------------- ---------------------------------------------------------H-IP----------- ---------------------------------------AVTE-----KSKLYY------------------ --------NKQPN--NII----------Q-------------------------------GLGIE-F----- ------------ELIQIISK-A----------------------M----N----------F----------- ------------K----PKYYI-QQNIPLKQK---DI-EGS------------------------------- -----------------------------NQTD--------------------------------------- TG------------------------LIS---KV--------------IE-E--------------N---AA FYLG-----------------------------------------------------------DLHYT---- -LQN---LNY--L-----------DL-T-IP-----YNIEC---LTF-------------L----------- -------------------------------TPES-LT-ENSWK------------LLILP---FK------ ---------------------------------QFYT--W-IAL-ILT-------LI-L---GS-----IVF YFLSLS------------------------------------------------------------------ ----------------------YKKHISS------------------------------------------- ----------------------------YKSQNTSIK----------------------------------- ------------------------------------------------------------------------ ---------------------------------NETKG-LYLFT------------EIG------------- ------------------------------------N-----SILY---TYS--------MLF-----QVS- --------L-PHL-PSPWAVRILIGW------WWI-----YSILVAVAYRA-----SM-----TA-TLANPV A--RV-----------------------TID-----TLAQLAKSSME-VG---------------------- -------------------------GLNEE-------------SKNFF----L------------------- -------------K----------------------------------SS-DL--------SSQEI------ ----------------GNKF-------------------------------------IIIKHEDE--A---- IEKVA----------N-G-------S-F-C-YYENSYFLQYARVKRQIF---EKEKKRN-ETANNRSS---- --KHNLHIMEEC-IIN-MP-------------------------------------------------IALG MEKN-S-P-------------------------LKPKVDIL-----------IRRMIEIGLVKK-------- ---W---------------LNDVM-------------EWPKIM----------------------------- ---------------EIRQEAESEKALVNLHKLKGAFFAII-------------FGYLL-AFM----ILIGE IL---------------------------------YW----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----KYIVLKDPKFDKYH----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AmelIR75f.1/1-552 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------NF------- ------KLAKT------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------FN-------------------------------- -----------------------NMY-----TTYISMLNSTVELRLD------VKKIL-R------------ ------------------------------------------------------------------------ --------------------AEYHRLGI-----------------------------------------FLD S--------------------------------------------------------RCDRSR--------- -----YRR-IL------------ID-AT--------------------KY---------------------- -----------------------SMY----------DE---------------M------------------ --------HKWLILGSN------------------------------------------------------- ------------------------------------------------------------------------ -LS--HVLE--------------------IL-ND-------------------------------------- ---ETFS--VS-TDVIIAV----------------------------------------------------- ------------------------------------------------------------------------ ---P--------------------------------------------SA---------------------- -------------------------------------------------DN--------------------- ---------------------YI--LYDVYNP--------------------------------CKDRGGSM NVTYFGMW--------------------------------------------------NFKTGL-------- ------------------------------------------------------------------------ -------------------------------------N-V------NLNQ-SKF--ARRSN----------- ----------LHGMK-LKVGIV-------------------------------------------------- -----------------V---------------------------------------N-FKPENMSLHDMML --------------------------------------QYSMK----------------------------- -----------SKYGR--------------------------------------S-------KFL-Y----- ------------ILLQHMSD-I----------------------F----N----------F----------- ------------TM-KIVQINA------------QR-----RF----------------------------- ------------------------------DNSG-------------------------------------- -P------------------------IFA---AF--------------KK-K--------------L---ID FSAN-----------------------------------------------------------PVAMK---- -VDR---LHN--G-----------DI-IRPI-----WPIR----SCF-------------M-FRT------- --------------------------------IS--STKVKPD-------------QFLKP---LS------ ----------------------------------VKV--WYVIL-AMI-------GV-V---TT-----ILI IF---------------------------------------------------------------------- ----------------------LKLENIGTPTE--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------IYGL-----SVLL---TIG--------ALS-----QQG- ---------SAFI-PTRCASRIALLQ------VLF-----FSLLILNYYSA-----SV-----VSSRLKNKG E--K------------------------MND-----SLINLAKSNLK------------------------- -----------VAVE----------PTPYIR--------------S-F----L------------------- -------------Q----------------------------------VS-DK--------EVKYF------ -YDN-----------CWTKI-----------------------------PE-----LYKYLPLEE--G---- LNRVA----------E-G-------S-L-A-YHTMTDSAYPYIEHTFNY--------------RSICELTE- -----VH-LFR---AV----------------------------------------------------LAFY ARHH-S-P-------------------------FTELMKV-----------GLTKIHNVGIQKR-------E LIRWTA-------------------------------RKP-----------------FCPN----------- --------------------NLLIAEPLSIHEAAPIFIFLC-------------ISIIL-SIL----ICIIE ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AmelIR75u/1-507 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------ML----------SA---------------P------------------ --------LKWLLLRD----R-----------------------S---------------SVDGDWT----- ------------------------------------------------------------------------ --DERETLK-----------------------GM-------------------------------------- ----AVY--PD-SEVIVAR----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------KRRN--------------------- --------GV-----------VE--IRSVYRPSPFHE----AIE---------------------------- --EDRGNW--------------------------------------------------TIEHG--------- --------------------------------------------VRMPNL---------------------- -----------------------------Y---P------------------SS--QRRRD----------- ----------LRRTP-LKSCLV-------------------------------------------------- -----------------M---------------------------------------T-DP-------DTI- ---------------------------------------NHL------------------------------ ------------TDYE--------------------------------------NKHIDPVTKAN-Y----- ------------PWIMHIAN-R----------------------M----N----------A----------- ------------T----ISFRV------------TDS-WGYRS----------------------------- -------------------------------ENG---------------S---W------------------ SG------------------------MTG---ML--------------QR-R--------------E---ID IGGT-----------------------------------------------------------GTFFI---- -PQR---IGV--V-----------DY-IQLY-----THTR----ACF-------------I-FRQ------- --------------------------------PLLSTV-SN---------------IFTLP---FQ------ ----------------------------------RSV--W-IAI-AVF-------LL-L---LL-----VLL CFSTKWEY---------------------------------------------------------------- --------------------------RRG------------------------------------------- ---------------ASANTA-----------------RY---------------WQQFNPA---------- ------------------------------------------------------------------------ -----------------------------------EQT---------------------------------- ----------------------------------VSD-----NLMV---VLG--------AIA-----QQG- ---------YSYE-PYRVPSRIVTLM------LLI-----AALNLYASYTA-----NI-----VA-LLQSTT ---D------------------------SIK-----TPADLLHSPLK------------------------- -----------LGAQ----------DVVYSR--------------HFF----K------------------- -------------S----------------------------------FQ-DP--------IRRAI------ -VDQ-KIE----PKGQN----------------------------------------GSWMSVEE--G---- ARRVR----------N-E-------L-F-A-FHAERGALYKIMQETYYE--------------EEKCGIME- -----IDVMN---MLD----------------------------------------------------PLLV IQTR-S-P-------------------------YLEIVKN-----------AALLLRETGLKVR-------E DIRLYT-------------------------------NKP-----------------KCH------------ --------------------ERKSFVRIGFTECYFALVALG-------------YGTLL-SLV----VLAIE VV---------------------------------W------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AmelIR76b/1-469 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------MAI-------------------------------------- ---NKDNEE----------------GNS-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------IPSQ------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------ITVTSWN------------------------------------------------- ---------------------------------------------------------D-MP--------FSG -----------------------------------------I------------------------------ -----------VQK-N-------------GKW---------------------------IGQGYA-F----- ------------YIFDLISS-K----------------------L----N----------F----------- ------------T----YTIIP-PKE---------HI-LGNE------------------------------ -----------------------------SS----------------------------------------- -G------------------------ILG---LL--------------YE-K--------------K---VD IAVA-----------------------------------------------------------FLPML---- -PEM---RRY--C-----------SF-S-TL-----LDETK---LTA-------------V-MKR------- --------------------------------PQE-SA--TSS-------------GLLAP---FE------ ----------------------------------KTV--W-LLV-LTS-------LI-F---VG-----PII YLFANM------------------------------------------------------------------ --------------------RAKL-W---------------------------------------------- -----------------------------------------------------------HD----------- ------------------------------------------------------------------------ ----------------------------------PTSE-NF------------------------------- ---------------------------------SLSS-----CFWF---VYS--------SLL-----KQG- --------T-NII-ALTDSTRMLFAT------WWI-----FILILTSFYTA-----NL-----TA-FLTRPQ F--TL-----------------------SIS-----SLEDIVH-----------------------KEYN-- -----------WITYK---------GRIVD---------------FLL----S------------------- -------------Q----------------------------------NQ-QN--------DLSLL------ -NISKQQG---KGI--------------------------------------------FKYYEPS--R---- PILE---------LVS-T-------K-R-L-FLEETHYLESLIFKDYVN-K-----TRDHLEHNLRCT---- -----YVIMPGN-ILV-TS-------------------------------------------------RAFG FSHG-S-T-------------------------IEKHINKM-----------LLRLRETGITQF-------- ---K---------------KKEDL-------------PL-------------A---EICPVDLRS------- -----------------------TERQLRNTDLLLTYKVVI-------------GGYTI-ATI----IFLFE LI---------------------------------Y--AC-------I-S---------------------- --------------------YR-------------------------------------------------- ------------------------------------LQNRK------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------RQFI---NGRSYY-------------- ------------------------------------------------------VITNPVG-DRKLI----- ------------------------------------------------------------------------ ----------------------------------------PIRTPS-------------------------- ------------------------------------AFLFQYTT---------------------------- >AmelIR8a/1-895 ------------------------------------------------------------------------ ---------------------------------------------------------MSTTLVAV------- ----------------CALLLTFLGVSICQISM--------------------------------------- --NML------------------------------------------------------------------- -------------------------IVIEEPDK--------------------------------------- ----------------SILNILNEAL-----------PQAEKNYGN----------------DIISVH---- --ISTIEVERSNTDA-S--FKKVCAALF--------K-GISIVL---------------------------- ---------------------------------------------------------------------DMT WTG----------------------WDTLRNKANENGI-----------------IYKRGDSN--------- -------------------INPYIQ--------AIDDL---LML-KN------ATDV--------------- -----------------------------A--------LIFE-DERE------------------------- ---------------------------LN--QSLYYLIGNS-----------------------ILRLIVID -------------------------EFTEKT-----------VSKIKSMRPSP-SY---------------- --------YAI-------YAS--TAKME-------------------------------------------- -----------------------DYF-----------RTA------------VQG---GLVK---------- ----RNG--IWKLI----------------------------------------------FTDNNY------ ---KDFKYINGDLQLNVSITVLWMKMDVCCR--LIGESLCN---------CPSNVK---------------- -----------------------------IF----------------------------------------- -----------SNYFKRLV----G--------------------------------LIVSL-M--------- ----SELQASG----V-------------------------------------SVEPKSVKCSSN------- -ANQ------SSNVTIEAFNK--------------------------------------------------- --NIVAKLGGNDTFE------------------------------YWPEKGMIT------------------ -----------------------------------Y------KAEIELKI------------LENGLLEPLA TWTRNGKI--------------------------------------------------KE------------ ------------------------------------------------------------------------ ------------------------------AENK------------------------KIL----------- ----------PAKRF-FRIGITPVI----------------------------------------------- --------------------------------------------------------KF-LP--------WII ------------------------------------------P-----KIDPA------------------- ------TGKVMKNE-N-------------GN---------------------------DMWDGYC-I----- ------------DFVKKLSE-E----------------------M----Q----------F----------- ------------D----YDLII-PED---------RQ-FGK------------------------------- -----------------------------KLPNG---------------Q---W------------------ NG------------------------LIG---DL--------------AK-G--------------E---TD IIVA-----------------------------------------------------------ALTMT---- -SER---EEV--I-----------DF-V-APY----FEQSG---LLI-------------V-MRK------- --------------------------------PVR-KP--SLFK-------------FMTV---LK------ ----------------------------------VEV--W-LSI-VGA-------LT-L---TG-----IMI WILDKY------------------------------------------------------------------ --------------------SPYS-ARN-------------------------------------------- -----N------------------------------KQLY-----------------P-------------- ------------------------------------------------------------------------ ----------------------------------YPCR-EF------------------------------- ---------------------------------TLKE-----SFWF---ALT--------SFT-----PQG- --------GGEA--PKALSSRILVAA------YWL-----FVVLMLATFTA-----NL-----AA-FLTVER M--QS-----------------------PVQ-----SLEQLARQS----------------------RIN-- -----------YTVVA---------NSSQH---------------QYF----I------------------- -------------NMKNAEDKLYTVWKEITLN---NTSDEVEYRVWDYPI-KE--------QYGHI------ -LQAITQV---GP----------------------------------------------VANSVE--G---- FRKVIESENA-----E-----------F-A-FIHDSSEIRY--------------------EVTKNCN---- -----LTEVGEV-FAE-QP-------------------------------------------------YAIA VQQG-S-H-------------------------LQEEISRK-----------ILDLQKDRYFEM-------- ---L---------------ASKYW-------------NQ-------------T-QKAQCLNSDD-------- ------------------------NEGITLESLGGVFIATL-------------FGLAL-AMI----TLAGE VF---------------------------------YY-RK-------R-NTETE------------------ ------------------------------------------------------------------------ -----------------------------------KSTKD------------------------------KK RKVKNKI----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------IQNL---TKMSLQM------------- ---------------------------------------------------KPAPINPFFEK-TN------- ------------------------------------------------------------------------ ------------------------------------------NPPRVS------------------------ -------HISVY----------------------PRNLPFKE------------------------------ >AmelIR93a/1-886 ------------------------------------------------------------------------ --------------------------------------------------MI-SVLLLVWWI--NYGSS--- ------------------------------------------------------------------YNNFPS ---LI-----------------------------------------------------------------TS N--------------------ATMAVIID------------------------------------------- -KGFFSNKDEYQNATKVIQDLITDAV-------KKE---MNL--------------------GSISIRVFRD --MNV-NF-K-DYTILL--SVATCYLTWRLHEVAQKE---ELTHFAITD----------------------- --------------------------------------------------------------------PDCP R----------------------------IPDTDGITV-----------------PSIV-PG---------- --------------------EELSQ--------IFLDLR--MTDILS------WNVIN-------------- --------------------------------------ILHD-DTFGDKATSSNDNV--------------- -----TILLSNANTCSR---LVSDRDTIS--RVLKAISNKLPNKRMN-----------------LISRSIFS LRHGN----------------TGS-GRKSSV-----------KKMLNDF--HVEQ--LG------------- ------HCFLV-------IAT--VDMVA-------------------------------------------- -----------------------DVM-----------SVA------------NSL---NMVH---------- -----PG-SQWLYV----------------------------------------------ITNSVSG----- ------------------------------------------------------------------------ ----NLINTSF----------------INLL----------------------------------------- ---------AEGGNVAFMY----NATNLDG--FYKIKLK-----------CYMKD-LIEAL-A--------- ----KALEYSLKNEIELFKRMNED------------------------------------------------ -EFE-MIRLTKSKKRAELLKN---------------------------VRIHLSRN---------------- ---------------------------------------------TSASNSVCE------------------ -----------------QCLLWRFFSSITWGNFFSH-------------------------------DRNMA HLLDIGTW-----------------------------------------------------TPIIG------ --------------------------------------------VNLTDV---------------------- ---------------------------------------I------FPHI--------VHG----------- ----------FRGIN-LPIATYH------------------------------------------------- ---------------------------------------------------------N-PP--------WQI -----------------------------------------IS----------------------------- -----------MSK-T-------------GK---------------------------KLYEGLI-F----- ------------DAINYLSM-K----------------------L----N----------F----------- ------------T----YTVIM-LE---------------T------------------------------- -----------------------------SQISR---------------S---W------------------ NTSQFAKLGEKIKEMTMSTTKKVPLEIID---LV--------------RQ-K--------------K---VL LAAC-----------------------------------------------------------ALTVN---- -ECG---NTT--F-----------NY-T-VP-----IFVQT---YSF-------------L-TAK------- --------------------------------PSQ-LS--RVL-------------LFASP---FT------ ----------------------------------KET--W-ACL-AVS-------II-I---MG-----PIL YLIHKY------------------------------------------------------------------ --------------------SPY------------------------------------------------- -----------------------------------------------------------ST----------- ------------------------------------------------------------------------ ----------------------------------KASG-LN------------------------------- ---------------------------------SSWQ-----CVWY---VYG--------ALL-----QQG- --------G-MYL-PQNDSARILIGM------WWL-----VVMVLVATYSG-----SL-----VA-FLTFPR M--DT-----------------------SIL-----SVEDLIAHK---------------------DSIS-- -----------WGFPN---------GSFLE---------------MYL----Q------------------- -------------N----------------------------------AE-EP--------KYHVL------ -FSRAERH---NDT-----------------------------------------------EEER--L---- VERVK----------E-G-------K-H-A-LIDWRSSLRFLMRKDFLL--------------TGSCH---- -----FSLSMDE-FLD-EP-------------------------------------------------IAMI IPYG-S-P-------------------------YLSVINAE-----------LHRMLESGLMNK-------- ---W---------------ITEKM-------------PM-------------K---DKCWEAPGSNQM---- ----------------------VNKRKVNVTDMQGIFFVLF-------------IGITL-AFF----FLFCE FY---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------CHR--------------------------- ------------------------------------------------------RKIA-------------- --------------------------------------------------KERKLIH--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------P--FVS------------------------------ >ApisIR21a/1-709 ------------------------------------------------------------------------ --------------------------------------------------------------MHPKL----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------DYRQLR----------------P---------------- ----WSCQL---------------P--------LYHRVPD-------------------------------- ---------------------RLLPPGAPV----------KD-NGIETS----------------------- -------------------LSVVSLSLPR--DVLQTMLPSLDTISYKL------------------------ ---------------------FNVYEYTSKR--------------------TRVSESKC------------- ------VNYII------FCQD--PEITA-------------------------------------------- -----------------------TKF----------GNAI------------DSRV--FIVTI-G------- --------SKWQIQ---------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------EFFKSP--------AS---------------------------- ---------QNIMNLLIAS----------------------------------------------------- ----AGPALQ-------------------------------------------------------------- -----EKNKNIKSRSYHVLTG---------------------------VKANRQN----------------- --------------------------------------------SIGNTKEILPVSVMR------------- ------HLYD-TTEPDIEVADIKLYTHEMYI-----------------------------------DGLGSS AQTILTTW---------------------------------------------------------------- ------------------------------------------KLNKFTRP---------------------- --------EVD----------------------------L------YPVK-------LVNG----------- ----------FRGHR-FILSAIE------------------------------------------------- ---------------------------------------------------------N-PP--------LVF --------------------------------------RSPL------------------------------ -------------SVD-------------KVL---------------------TQEQSTSWDGVE-I----- ------------RLLQIISR-V----------------------L----N----------F----------- ------------T----LGIHD-ATF---------SKSRGE----G-------------------------- -------------------------------DDR-------------------------------------- --------------------------IIG---DL--------------VA-S--------------K---AD IGIS-----------------------------------------------------------GLYMT---- -NAR--YSLV--------------DF-S-PV-----ILQDC---GTFVS-----------LGSFA------- -------------------------------LSK--------YR------------AIFGP---FH------ ----------------------------------WSI--W-VMV-VITY------MV-AIFPIAFTNNRNVG TLCKSP------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------K--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------QLES-----MCCY---MFG--------TYTN-LFTFKD- --------VKSWTNTKMGSTRLFIGT------YWI-----FTIIITTAYTS-----SI-----IA-FITLPE Q--PV-----------------------IVD-----KSYQLVDQGYR------------------VMTLD-- -------------------------KGGWQ---------------HYL----N------------------- -------------I----------------------------------TN-DT--------MSRRL------ ----------------LSNI-------------------------------------KLMKNLDD--A---- IDYIVRTRF---IL-----------D-Y-A-FLGSKISLTYLSQNNFIQ-----------KYNNKKIF---- -----LHVASEC-YVP------------------------------------------FN--------IGIA YKKN-F-V-------------------------FRNIFSNF-----------ILRAQQSGLVTKIIKDIE-- ---WEI-------------TQKS----------------------------------------GVRNPNLI- --------------------IAPEDRQLALDDVQGMFVLLG-------------GGIFL-AAF----TLSIE FV---------------------------------KCKRE-------N-RKIAQ------------------ ------------------IKIEKH-LKKKKRS---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------KSL-------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------TVRGNT-------------- ---------------------------------------------------TVEPFRPLTAF---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >ApisIR40a/1-663 ------------------------------------------------------------------------ ---------------------------------------------------------IYIFFLIRS------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------TIYY----------------------------------------------------------- --------------------------------------------------------------VSF------- ------------------------------------------------------------------------ -------SGRDI------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------FKNTVASAIC-------------------------------- ------------------------NEYSIV--------VLTN-XNANI------------------------ -------------------------------IMLILI---------------------------NIIFISLY LSSSI------------------------------------------------------------------- -ILIDYNTYL--------IIQNLLVNVT-------------------------------------------- --------------------IYINIYR--LLGLHRDGDFL-------FFTQIRRS---NLMSR--------- -------NVVYVFL----------------------------------WLR--------------------- ------------------------------------------------------------------------ ------------------------SSVSRTFKAD--------IL---------------------------- ----------EAMRVCVIT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------SPRPGFY-------------------- ----------------------QIYYSQA-----------------------------------SARPGYGS SLKMVNWW---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------SAMD-GLVRFP-----L------LPPP-KQV----YKN----------- ----------FEGRY-FNVPVLH------------------------------------------------- ---------------------------------------------------------K-PPW------TFVE -----------------------------------YLN---------------------------------- ------------D-------------------------------------------------SFR-V----- ------EGGRDDKLINLLAD-K----------------------L----H----------F----------- ------------Q----FKYID-PPDRT----------QGS------------------------------- ----------------------------GLDRGS---------------S---M------------------ QG------------------------VLG---LI--------------WQ-R--------------E---AD WFVG-----------------------------------------------------------DLSIT---- -YER---NLV--V-----------DF-S--------FLTLVDN-EAF-------------L-THA------- --------------------------------PGR-LN--EAF-------------SLIRP---FH------ ----------------------------------WSV--W-PLL-LIT-------VI-F---AG-----PIL YILVDTTDG--------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------------------HPQG------ ------------------------------------------------------------------------ -----------------------------------KSM---------------------------------- ---------------------------------LYWK-----CVWW---SVT--------VFL-----QQA- --------A-IIP-SENNKIRFVAGL------LMLS----VTYVIGDMYSA-----SL-----TS-ILARPP K--EP-----------------------PIN-----TLKELSEAMRD-------------------SGLQ-- -----------LLVEV---------QSASQ---------------AML----E------------------- ------------------------------------------------NG-TG--------VYEEL------ -SQLVTRQR-----------------------------------------------EYLIGSTEK--G---- MQLVR----------D-N------KN-Y-A-VIGGRETFYYDIKRFGAQH---------------------- -----FHLSE--KLNTRYS--------------------------------------------------AIA FQRA-C-P-------------------------YRDNFDDV-----------LMRLFEGGILSK-------- -----------------ITEEEYQKLNDK-----LMGSEE---------------FDSTSVVIEPVLEG--- ------------SEPRQEDDDKQLTIAMSMKTLQGAFYVLA-------------IGSIL-AGL----LLLIE M----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------RSHDKLEKDKVI------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------KLVEAPF- VY---------------------------------------------------------------------- ----------------------------------------------------KRKVPNKFQN---------- ---------------------------------------------------RLYDLK--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >ApisIR68a/1-658 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------SY---------------------------------- ------KEIKWN-----SEFENLAVD-------ITYKWKD-------------------------------- -----------------------TATC-LN--------LILD-NFHN------------------------- --------------------GILDKAFYR--AVSG------------------------------IPLFKT- -----------------------LVDESEDLMSPNF----QTWQILNHVR-----KEGC------------- ------NMNII------FILN--ADQTM-------------------------------------------- -----------------------RLL-----------KFS------------DKH---RMLD---------- -----SR-TKFILL------------------------------------------HDRRLFTKQHH----- ----------------------------------------------------------------------T- ------------------------------I------------W---------------------------- ---------TKIINVVFIR----------------------------------------------------- --------------------------------KYRLK----------------------------------- ------------------------------------------------------------------------ ---------------------------------------------D-------------------------- --------------------MYELSTVPY-----------------------------------PAPIKGAL VTLRLDIW---------------------------------------------------------------- ------------------------------------------------------------------------ --------N-----------------KRNFQKKT---D-L------YTDK--------VSD----------- ----------LQGNL-LKVVTFN------------------------------------------------- ---------------------------------------------------------Y-IP----------- ---------------------------------------SAIK----------------------------- ---------------NSV----------INEN----------------------EENSGYKKGLE-I----- ------------EVLKSLGS-A----------------------M----N----------F----------- ------------I----PVIYE-PINW---RT---EQ-WGK------------------------------- -----------------------------KQING---------------T---I------------------ SG------------------------LLG---EV--------------WS-A--------------R---AD LALG-----------------------------------------------------------NLHYT---- -PYH---LNI--L-----------DL-S-IP-----YNTEC---LTF-------------L----------- -------------------------------TFES-KT-DNSWK------------TLILP---FR------ ----------------------------------LNM--W-VGV-LIT-------LL-I---GG-----FLF YALATA------------------------------------------------------------------ -------------------------HKHIE-----------------------------------------D SENSIKMI---------------------QCDTMKTKILE-------------------KK----------- ------------------------------------------------------------------------ -----------------------------PELLTKNKG-ITK----------------R------------- ------------------------------------N-----SILY---TFG--------MLV-----AVS- --------L-PKV-PSGWAIRILTGW------WWM-----YCLLVVVAYKA-----SM-----TA-ILANPD T--RV-----------------------TID-----TLDALADSNIN-CG---------------------- -------------------------GWGEQ-------------SKEFF----M------------------- -------------T----------------------------------SL-DK--------TGQRV------ ----------------GQKF-------------------------------------QEVYEVDK--A---- IDLVS----------K-G-------Q-F-A-YYDNIHFLRYVKVMQN---------TKTYEKNSQFIN---- --DFTLHIMSKC-IIN-MP-------------------------------------------------ISLG LQKN-S-P-------------------------LKPAVDRF-----------LRRVIEAGLVKK-------- ---W---------------LNDVM-------------LDTVIL----------------------------- ---------------EEPQQIEEVKALMDLKKLYGAFVVLV-------------AGYIL-SIL----VLLIE IG---------------------------------YW----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----YGVVKKDPLFDEYSLNCYY-----------AQQ---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >ApisIR75d.1/1-635 -----------------------------------------------------MRNPMIL------------ -----------------------------------------------------LWLCL-------------- ------------------------------------------------------------------------ ---VASTF---------------------------------------------------------------- ---------------------RTSVEY--------------------------------------------- ------------------DSLINA-LTR-----------------------------------VFV------ ------H--KHVQTVTA----TTC------------------------------------------------ ------------------------------------------------------------------------ -----------------------------W------------------------------------------ ------------------PTD---AN-----GRLLLALS-SADISVN------FRP---------------- -------------------------------------------------------SL--------------- -------IPVHKT--------WYKYG-I-----------------------------------------LVD VSC------------------------------------------------------SVQIP---------- ------TT-LF------------RK-AS--------------------KH---------------------- -----------------------RLF----------NM---------------Q------------------ --------NDWILINSRRNES-----------------------H---------------VLNTSVI----- ------------------------------------------------------------------------ --ALETFEM--------------------HLSEA-------------------------------------- ----YVL--PE-SNV--------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------FLFIDTPSGWEI----WEG---------------------------- --FKVGKM--------------------------------------------------ER------------ ------------------------------------------IQVKRHGM---------------------- ----------------VT------SDGIYFEKND------------------SI--SFKSN----------- ----------LRGIT-LKATTV-------------------------------------------------- -----------------I---------------------------------------S-EP-------SKF- ---------------------------------------KGF------------------------------ ------------YPFA--------------------------------------DTDLDTFAHMH-Y----- ------------DLNMILQD-Q----------------------L----N----------F----------- ------------K----IDLGI------------VNS-FGWDM----------------------------- -------------------------------GNA---------------S---F------------------ SG------------------------LTG---QL--------------QR-E--------------E---CD FSGI-----------------------------------------------------------GVFIR---- -NDR---MTV--I-----------DY-TVGT-----FYRQ----AAA-------------L-FKQ------- --------------------------------PPLSSV-HN---------------ICILP---FK------ ----------------------------------FEV--W-MVT-LFT-------FI-G---FT-----ILI AFLSR------------------------------------------------------------------- ------------------------MTRR-------------------------------------------- ---------------LKKDEE----------------ETL---------------NVL-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------D-----SVTI---VHG--------AIC-----QQG- ---------YTMN-LNAGSIRVAIFV------LFL-----TAVFLFTSYSA-----SI-----VA-LLQSPS ---N------------------------SIK-----TINDLVESSMT------------------------- -----------FSAQ----------DNPYND--------------VYF----G------------------- -------------E----------------------------------TD-DP--------LLRKL------ -YDK-KMR----PHGT-----------------------------------------QKFTLASA--G---- IARIR----------T-E-------F-H-G-FMIDFVSAYKLISQLWLE--------------EEKCGLSE- -----IQLFK---LPM----------------------------------------------------LALA VVKR-S-G-------------------------YKDILKQ-----------KLIHQQEVGLKNR-------I IRRWIP-------------------------------AKP-----------------MCDSSN--------- --------------------RANQFVSVSIKEIYPMLQIYG-------------FGLCI-SIV----ILFVE IV---------------------------------Y-NTY-------TDRSEN------------------- ------------------------------------------------------------------------ -------------------------------------LHSN------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------TYFSIFR FM---------------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------YNK-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >BmorIR21a/1-854 ----------------------------------------------------MDRRSLY------------- -----------------------------------------------------GLL-FIFYIIS-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------SQEIISYHSES-----LLKNASRNLLWNKKIT-------------SIIK------ ------------------------------------------------------------------------ ---------------------------------------------------------------------EHN DFAYHYESDLHF-------------GNRIKNVKSKRAVD----------------PVFHGHPKTRE------ --ELWYERFLNRSSVF-DQTPSLIK--------LIQNITL-------------------------------- ---------------------TYLNECTPV--------ILYD-SQIKLK----------------------- -------------------ESYLFQNLLR--NFPVSFVHGYINEHSQL------------------------ --------------------------QEPKL--------------------LQPVR-EC------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------EVVRALAS-A----------------------G----N----------F----------- ------------T----LNFQEVPPG----EV------WGE------------------------------- -----------------------------LLPNG---------------S---W------------------ NG------------------------IIG---ML--------------GS-G--------------A---AD FAIA-----------------------------------------------------------DIFITSLWG RTDH---QH----------------F-S-AP-----FDQGV---NCV-------------I-MRV------- --------------------------------PPP-LP---------------RWQAPLWP---FR------ ----------------------------------EDT--W-QAF-LVG-------FV-L---SG-----PLL YCLARG------------------------------------------------------------------ --------------------SARS------------------------------------------------ ---------------------------------------L-----------------GKTS----------- ------------------------------------------------------------------------ ---------------------------------------YLE------------------------------ ---------------------------------SLTS-----SYLY---ATG--------MHL-----QEP- --------L-ARE-PITNTSRVIVAF------LWL-----YAMVLGFSYSS-----NL-----TA-FLTVTR Q--PR-----------------------TID-----TYKDLYESRLT-IVGLG------------------- ---------------------------------------------PTL----G------------------- -------------SLMET------------------------------SV-NF--------YLREL------ ------------------YK-------------------------------------QFAPLPSD--D--AA VQAVL----------D-G-------R-A-G-YITSYHNSKYIVAKLNSAQ-------------R--TP---- ----ILRVMKEC-TMP------------------------------------------FS--------VAVG LQSN-T-P-------------------------LKPRIDLV-----------TYKIVESGLVSQ-------- ---W---------------FKESVWI--------A--TR------EN-----RMQQKGTNKEEETND----- -----------------------E----------------------------------------------TE -----------------------------------VF----------------------------------- ------------------------------------------------------------------------ ---------------------------------RVLPLK--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR21a/1-914 ------------------------------------------------------MKSVL------------- -----------------------------------------------------LISAFCFVWMELLLAWQQQ S----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------SDPYRQALVNYRSDA-----P-KNKFYELSSEQYIP-------------GTVD------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------ADSG--------------------VREKRLSD----------------PTFRGNPKTRE------ --QIWAKKFAHILVND-RQSKSLVD--------LLIRVVT-------------------------------- ---------------------KYLHACIPI--------ILFD-SYVEQK----------------------- -------------------EGLMMESLFR--QFPLTYTCGKIGLNYTL------------------------ --------------------------ENPEI--------------------LATTASKC------------- ------RSYII------FLSD--ALMTR-------------------------------------------- -----------------------HII----------GPQL------------TDYV--VVIPR-S------- --------SQWKLQ---------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------DFLSSK--------ES---------------------------- ---------RDILNLLVIG----------------------------------------------------- ----ESYSAG-------------------------------------------------------------- --------KSANEEVPYV------------------------------------------------------ ------------------------------------------------------------------------ -----------------------LYTHDLYI-----------------------------------DGLGSN RPIVLTTW---------------------------------------------------------------- ------------------------------------------MNGKFSRT---------------------- --------NVD----------------------------L------FPKK-------IRKG----------- ----------FSGHR-FTVALAH------------------------------------------------- ---------------------------------------------------------Q-PP--------FVF --------------------------------------KQL------------------------------- -------------STD-------------A-----------------------VGNIAIRWDGIE-I----- ------------RVLKTMGN-Y----------------------L----N----------F----------- ------------T----IDYKE-PSK---------GYL-GP----G-------------------------- --------------------------------DA-------------------------------------- --------------------------ITD---EV--------------ER-R--------------Q---AD IGVA-----------------------------------------------------------GAYVT---- -IER--NVNT--------------EM-T-VS-----HSSDC---SAFIT-----------LMSSS------- -------------------------------LPRQ-----DLYR------------AILGP---FQ------ ----------------------------------WPV--W-LAL-TLIY------LL-AIFPLAFSDKLSLR HLIGNW------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------S--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------EIEN-----MFWY---VFG--------TFTN-SLTFTG- --------ENSWSNTKKTSTRMLIGI------YWM-----FTIIITSCYTG-----SI-----IA-FVTMPV L--PD-----------------------TVD-----TVAELRRGFYR------------------VGTLD-- -------------------------RGGWE---------------RWF----L------------------- -------------N----------------------------------SS-DA--------STAKL------ ----------------LKKL-------------------------------------EFVSSLEE--G---- IKNVTDAW----LI-----------S-Y-A-FIGSKAELNYLVQSNYSD-----------ESHNKRYE---- -----LHVSKEC-FSL------------------------------------------FG--------VSFV LPQK-S-V-------------------------YRDKFNNA-----------ILYMQEAGIIGKLSKDVS-- ---WDM-------------QRTS--------------------------------DGRFRQA-SVGKTLRS- -------------------PTAGAEKGLTLGDTEGMFLLMG-------------IGYLL-GLA----VLISE WI---------------------------------GGCTN-------------------------------- -------------------KCKEL-IEARKDRF--------------------------------------- ------------------------RR------------SSTSSIPASSAS-------------------SAN QNSPRRR--PTGK-------------------------------EYNLMYNGD-----------SSSQALTP RAGFDD----------------------------------------DSGSDISEGTRTRRTLSE-SLQDVGQ ---NTLQELYDGPNRRHSTIVYID-----------------------------------------------G KMMSE--------------------------------EEAQRYAATK-----KSNRSHSSLG---------- -----------------------------------------------S--VVEHEVTRLFKFLDDRKGS--- ------------------------------------------------------------------------ ------------------------------------HEEHRPKHSRHHSRS--------------------- --------IEVAAEVN-RMVDDAE--------KQVVEKSFGEELLH-------------------------- >CquiIR25a/1-818 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------VCSKYSEALNTN--R-MPHVIL---------------------------- ---------------------------------------------------------------------DTT LTGV--------------------ASETVKSISVALGI-----------------PTVSTSFGQEGDIRQWR SLSPEKGNYLLQI---MPPTDMIPE--------VIRSI---IIY-MN------ITNA--------------- -----------------------------A--------ILYD-DSFV------------------------- ---------------------------MD--HKYKALLQNI-----------------------PTRHVITS IG----------------------ND--KDR-----------GEQIEKLRNLDINN---------------- 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----------L--LL-INVYFLQ------------------------------------------------- ---------------------------------------------------------Q-EP--------FIF ------------------------------------------------------------------------ -----------RDP-S-------------AP---------------------------KGFKGYC-I----- ------------DLLDEIAK-I----------------------V----K----------F----------- ------------D----YEIKA-VED---------GK-FGN------------------------------- -----------------------------MNEKG---------------E---W------------------ NG------------------------IVR---KL--------------ID-K--------------Q---AD IGLG-----------------------------------------------------------SMSVM---- -AER---ETV--I-----------DF-T-VPY----YDLVG---ISI-------------M-MQL------- --------------------------------PST-PS--SLFK-------------FLTV---LE------ ----------------------------------TNV--W-LCI-LAA-------YF-F---TS-----FLM WIFDRY------------------------------------------------------------------ --------------------SPYS-YQN-------------------------------------------- -----N------------------------------REKY-----------------KND------------ ------------------------------------------------------------------------ ----------------------------------DEKR-EF------------------------------- ---------------------------------NIKE-----CLWF---CMT--------SLT-----PQG- --------GGEA--PKNLSGRLVAAT------WWL-----FGFIIIASYTA-----NL-----AA-FLTVSR L--DT-----------------------PVE-----SLDDLSKQY----------------------KIL-- -----------YAPLN---------GSSAM---------------TYF----Q------------------- -------------RMADIESRFYEIWKEMSLNDSLTPVERSKLAVWDYPV-SD--------KYTKM------ -WQAMQEA---GL----------------------------------------------PNSLDE--A---- VERIRNSTSA-----S---------G-F-A-FLGDATDIRY--------------------KVLTNCD---- -----LQMVGEE-FSR-KP-------------------------------------------------YAIA VQQG-S-P-------------------------LKDQFNNA-----------ILMLLNKRQLEK-------- ---L---------------KEQWW-------------KN-------------DDIQSKCEKPDDQ------- ------------------------SDGISIQNIGGVFIVIF-------------VGIGM-ACI----TLVFE FW---------------------------------YY-KY-------R-KNI-------------------- ------------------------------------------------------------------------ ------------------------------------KIVD-VMEAND------------------------E NS---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR31a/1-539 ------------------------------------------------------------------------ -----------------------------------------------------MYFL--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------WS----- ------ELSKTARLLVLHYKTSRCRQSK-------------------------------------------- ------------------------------------------------------------------------ ----------------------GTLVVPSKKVSNLFISTNDE------------------------------ -----------------------NIS-----ARFINLAG--LN-SKD------PTSFLPH------------ ------------------------------------------------------------------------ --------------------NSYAITTC-----------------------------------------IFD Y--------------------------------------------------------SCTNS---------- 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----------FNGLQ-VR-GTT-------------------------------------------------- -----------------V-------------------------------------------DNVTS-QDV-- ---------------------------------------DRIL----------------------------- -----------SVPGT--------------------------------------EQGIVSFVKYH-Y----- ------------ALLVMLRD-Y----------------------H----N---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------FG----AGF-------------I-YRI------- --------------------------------TPQLSGATGGG-------------NFFTP---FE------ ----------------------------------DSV--WIASL-ITL--------------TA-----ILV ILKFS------------------------------------------------------------------- ---------------------VFIIFKSASNEP--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------NT----------------------------------- ---------------------------------SLIS-----YLVD---IVG--------TVS-----QQGI ---------AGRV-SARMPIRIILFS------LLT-----LNLVLFNYYTS-----SV-----VGGLLSSPG ---K------------------------GPQ-----TIREIIDSPLK------------------------- -----------LAFR----------DIGYHK--------------ILF----R------------------- -------------E----------------------------------TQ-VP--------IIREL------ -YEK-KVQ---PSREGKHTI-----------------------------P--------VYTDVIT--A---- VPYLQ----------R-G-------G-Y-A-FHCEMTEAFQDIADQFDA--------------NEICELRT- -----TTGLFN-DLRL----------------------------------------------------MSFV VPKR-S-M-------------------------YTEMFRI-----------TMMRLQEIGLIKR-------T LKINRI-------------------------------EKP-----------------ICQS----------- --------------------RGRV-LPVEVSGVSTAFAVLG-------------G----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR40a/1-740 ------------------------------------------------------------------------ ---------------------------------------------------------MKVGIV--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------W----------------------------------------------------------- --------------------------------------------------------------CLF------- ---------------VL------------------------------------------------------- -------LGRSF------------------------------------------------------------ ------------------------------VQAYHSQLVPI------------------------------- --------------ADPSNHSGMVTG----LSEMINLLSP-------------------------------- ------------------------KTLVLL--------VLNE-TKIHK------------------------ ---------------------------ID--RLTVAIHSY------------------------NIPTCIFY ------------------------------------------------------------------------ ----DLEQYFE------YIANNLKNSLD-------------------------------------------- ---------------------TTSLL------LCHPAD---------MLVDLVDR---RLAHR--------- -------LSLYIFY----------------------------------WGA--------------------- ------------------------------------------------------------------------ ------------------------RRLPAGFDRA--------LL---------------------------- ---------REPLRVAVIT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------NPKKKIF-------------------- ----------------------RIFYNQ-------------------------------------AKPNNLG ELLSANWF---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------DGSDMTFKRVP-----L------LPTP-TEV----YKN----------- ----------FEGRV-FTIPVIH------------------------------------------------- ---------------------------------------------------------K-PPW------HFLT -----------------------------------YTNLNESC----------------------------- ---------------NDTDTE----------------------------------FDMANVTSFQ-V----- ------TGGRDHNLMQLIAA-R----------------------M----N----------F----------- ------------T----FRYIE-PEEKI----------QGTAM----------------------------- ----------------------------GSGDNV---------------S---I------------------ SG------------------------ALG---ML--------------QR-R--------------E---VD LFLG-----------------------------------------------------------DVAVT---- -WER---MQA--V-----------EF-S--------FFTLADS-AAF-------------V-THA------- --------------------------------PRK-LS--EAL-------------ALVRP---FQ------ ----------------------------------VTV--W-PLV-IFT-------II-L---SG-----PVL YLIIAMPFRLEDWMKG-------------------------------------------------------- ------------------TLDKARRLQVR------RG----------------------------------- -----PPFY---------------------------DMQYIREMGYGLVP--RA-DIAGTPQH--------- ------------------------------------------------------------------------ -----------------------------------PS----------------------------------- ----------------------------------LNR-----CVWY---TIN--------VYL-----RQS- --------A-TIP-YNGHVARFFSIL------LWLC----ATYVLGDVYSA-----QL-----TS-QLARPA R--EG-----------------------PIN-----TLGKLEELMESP-----------------GGGYQ-- -----------LLVER---------QSAFQ---------------VAL----A------------------- ------------------------------------------------NS-TG--------ILQRL------ -YRITQRHPDNE--------------------------------------------SYLVGSVEE--G---- IQILL----------V-N------SK-R-A-VFGGRETLYFNTKRYGAHR---------------------- -----FQLSD--NLYTRYS--------------------------------------------------AVA VQFG-S-P-------------------------FLDSLNEV-----------IMRLFEAGIIGK-------- -----------------ITVAEYERMFGSKSGG-QFADE------------------TVESTKSDDGVD--- -------A-TGKAKKSAESSEK--LQPMNLRMLQGAFLALG-------------FGHSV-GAI----ILLVE N----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------QLK-------------GI------------------ ------------------------------------------------------------------------ -------------------------------------KSV------------YQRVLGVLTRTGRVVRKIWT AI---------------------------------------------------------------------- ----------------------------------------------------RRSL---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR41a/1-626 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------MVSL-------LVGL------------------------------- ------------------AVN---------IPQYFNDLYC-------------------------------- ------------------------------------TCFISNTNDIDF--ELNFELS--------------- -----------------------------------------------------------------QPVIWID IEKANSED------------------------------------LLSSIE------NGC------------- 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----------LQGRF-LRLAIFN------------------------------------------------- ---------------------------------------------------------Y-SP--------YTF WNEV-------------------------------------------------------------------- ------------NISS------------DSNAYFEH-------------------EASLQVDGTE-S----- ------------RIFSLFCD-T----------------------F----N----C----------------- ------------S----LEISLDEAGE-----------WGE------------------------------- -----------------------------IFDNR---------------T--------G------------- NG------------------------IIG---AV--------------VE-R--------------R---AD IGVG-----------------------------------------------------------ALYSW---- -YHE---FTF--L-----------TL-S-KP-----ISRTG---VTC-------------I-TPK------- --------------------------------PKLLSS----------------WMTPILP---FT------ ----------------------------------PNL--W-AAV-AVT-------FV-L---AS-----IFA LFINFM------------------------------------------------------------------ -------------VN--KIVLTQVSLKMCC------------------------------------------ --------------------------L------------------------------LKTK----------- ---------C-------------------------------------------------------------- -------------------------------DTLQDIQVDIC-------------ES--------------- -------------------------------------------FMI---IGS--------MFI-----LQTV L-------LRINR-NKYISQMVLIGS------VLF-----VGMMLGNVYSG-----GL-----SS-VMTIPR Y--QK-----------------------PID-----TLLDLANN-----------------------DLH-- -----------WASTHD----------------------------AWIFSI-L------------------- -------------M----------------------------------AT-QPT-------IL-KL----LQ NFETHPKEV----------------------------------------------LHRHAIQQDL--A--YS VERLP-------Y----G-------H-F-A---------------------------IGEYIDREVSH---- Y----FHLMIEDIYWE----------------------------------------------------NCVA MSTK-TWP-------------------------MMDHLDGL-----------ILRVFESGIQRY-------- ---WEL-----------QVVSKYA--------D----NK---------------VQLTIATSRHQESS---- -------G----------------PTILQPSHLVGAFLLLA-------------FGLAS-GFM----IFVME IAVG----------------------------------KL-------HGAK--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR60a/1-645 ------------------------------------------------------------------------ -----------------------------------------------------MQWPRLTFLLGFAALGP-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------TTDGIVYVRTKNERG---------PTAIQAGIN-------- ------------------------------CLELLTGAYFY---PTE------SVQIQ-------------- ------------------------------------NIVVFHLHNL-------------------------- -------------------SSPS-----R--EIELGFLQSHH--------TGY------HEDLDGRKTQHFQ ---------------------------------------------LKMMSDK-------------------- ---------LP------------RSSIR-------------------------------------------- ---------------------KQAFV---------DYKLI-----DYYVIVVDEFE--KLERAMSYISL--- AYAFNPR-GKYVVLYNN-------------------------------------------PNNRDLDDRFA- ------------------------------------------------------------------------ ------------------------LEALNFMFIK-------------------------------------- ---------HHSVNVLVAF-------------------------------------------A--------- ----------------------------------------I------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------DMMSYAVYTGDPYHGTR--------------------------------KDCGRM KTLKIATV---------------------------------------------------------------- -----------------------------------------------------------------------Q NG-----------------------------------T---------------------------------- ----------FRNEA-LAMEMIR------------------------------------------------- -----------------MS--------------------------------------KVPPE--MESCTFLF ------------------------------------------------------------------------ ----------------------------CTRE-------------------AAPFINAGCETGLE-I----- ------------QIMHLLQE-S----------------------M----K----------F----------- ------------N----VNVSCSTME------------RGE------------------------------- -----------------------------LEDDG--------------VT---W------------------ SD------------------------LLG---LM--------------RD-D--------------E---CD L---------------------------------------------------------------IAGA-FY- -PDY-------DVHA---------DFAA-TTL----YLQDY---YTW------------FVQTAG------- --------------------------------LQS------RWK------------VLLDI---FE------ ----------------------------------IST--W-ELF-ALV-------LF-V---C------SLT WFLVGT------------------------------------------------------------------ -----------------------------------------------------------AL----------- ------------------------------------------------------------P----------- ------------------------------------------------------------------------ --------------------------------ELRPHK---------------------------------- ---------------------------------CFST-----CILN---TWC--------VFL--GISTNN- ------R-------PNSNSLRIFFVA------LAL-----YSINVTTIYTS-----QL-----IN-VFTSPP R--EH-----------------------QID-----TIEEILNMTTP------------------------- ------------------------IGGRMEYE-------------DWF----E------------------- ---------------------------------------------------NA--------DEDDLRV---- -SARYSNSD------------------------------------------------EFQPSEAN------- MRAVA----------K-GR------R---V-ILTSRAYV-------------------------RNSHYYGE -----VHGLKQDVFAT----------------------------------Q-----------------IEMI MEKG-F-P-------------------------LLPKFNRI-----------ISNLNDMGITGKL------- ---FQD-------FIFNVTILHKI-------------QDI------------ISPDEDDDLELPP--NE--- -------------------------IVLTLDHMQSAFSTFM-------------MGIVV-SCV----AFLCE ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR64a/1-821 ------------------------------------------------------------------------ --------------------------------------------------------------------MLLE YRW--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------PKARPNQKPA------------------------------ ------------------------TH-----N---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------LQAS--------------------RY---------------------- -----------------------ELF----------NA---------------S------------------ --------FHWLIIDKK-----------------ASSTNDDEAPDGTGPDRLQRGQWRN-CRRRSQ-----V PPLFGRGPPAVSGGN--NGSFCS-----------------DDGDE--------------------------- --DTTTLD---------------------RLETM-------------------------------------- ----NIS--IN-AEITLVR----------------------------------------------------- ------------------------------------------------------------------------ ---E--------------------------------------------SSVAGGA----------------- ---------------------------------------------TANGDR--------------------- --------RR---------KVYA--LFDIWNPGFISG----GQL---------------------------- NVTAMGNY--------------------------------------------------VVDNA--------- ------------------------------------------------------------------------ ---------------------GGGRLTVWFHQST------------------VV--RRR-D----------- ----------MRGLK-LKMMTV-------------------------------------------------- -----------------V---------------------------------------T-QRP---GI-PFE- ---------------------------------------VYL------------------------------ ------------ATPN--------------------------------------NTHLDSVHRYN-F----- ------------GLMSYIRD-Y----------------------F----N----------F----------- ------------S----FIMRR------------TKS-WG-------------------------------- -----------------------------YLRNG---------------T---F------------------ DG------------------------MIG---AL--------------SR-R--------------E---VD LGGS-----------------------------------------------------------PMFFR---- -QER---HRV--V-----------SY-TTRS-----FMER----PCF-------------I-FRH------- --------------------------------PKRQSTMRN---------------PFLLP---FE------ ----------------------------------TVI--W-YLM-VFC-------GA-L---LV-----VVL FASYHFEESVFFFSASTQSKENGILYIFILFLFPLFILSTFARDVGFVVRRGAAAKS-SPIHTNNFDGPLKI EADDESYYGDSFHFNRSLRPPPPAPARQGLNPKRQ------------------------------------- PGTKENVLFND---TNKNNDDDD-------------------------------------PNC--------- ---------CQQLVLRQWRKLLLSRRHLATSQHQQRQRQRKSLHSNNGDTTTNSSATTLQAASRGKAPVVLQ PAVHWVLPPG-GVEHK-ETGDDATWRSSSSNYKAEKLS---------------------------------- ------------------------------------K-----SILL---FLG--------GVC-----QQG- ---------LSEI-PRLPSGRCTSIF------ILV-----FGYLMFQFYSA-----SI-----VGSLLMAPP ---K------------------------TIR-----TLRNLIDSRLT------------------------- -----------LGIE----------DIPYSR--------------DYF----V------------------- -------------R----------------------------------TT-DA--------DSLEL------ -FHT-RVSF-YDQKSGQNE--------------------------------------SHFLNAAD--G---- LHLTR----------K-G-------G-Y-A-FHVAISAAYKIIRETFSE--------------LEICELTE- -----IDMFPK-SSQW----------------------------------------------------MVAI VQKN-S-P-------------------------YRDVITY-----------GLRRLNEAGIMDR-------Q RRVWQE-------------------------------PKP-----------------KCVRK---------- --------------------IAPSDLIVGMDSVYSAFILLV-------------AGSLL-SIG----LLLIE IL---------------------------------R-HRL-------A-VAR-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR68a/1-747 ------------------------------------------------------------------------ ------------------------------------------------------MEVVKICL----VFALAI A----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------I------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------ASAALNH---------------------------------- ------TLFEDEN--DLVDFGRLIVD-------LVGK-TK-------------------------------- -----------------------PGHC-YA--------FVTD-PIYR------------------------- --------------------VTLTDTLFK--EIGG------------------------------HPRFVV- -----------------------EIPEDEDTLRPGK----QVRCMLEEIR-----KIGC------------- 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----------LDGQT-MRVVVLE------------------------------------------------- ---------------------------------------------------------H-TP----------- ---------------------------------------AIFR----------------------------- ------------TTLNET----------SGER----------------------RQRIK-YSGLE-V----- ------------ELLKAVAQ-A----------------------M----R----------F----------- ------------E----MSLYE-TEDA---GT---EK-WGT------------------------------- -----------------------------IMEDD---------------N---S------------------ TG------------------------LLG---DM--------------NE-G--------------R---AD FALA-----------------------------------------------------------DLHYT---- -LYH---LQI--M-----------DL-S-IP-----YNTEC---LTF-------------L----------- -------------------------------TPEA-LT-DNSWT------------TLILP---FT------ ----------------------------------GGM--W-AGV-LVS-------LF-S---IG-----TVF YALSRLM----------------------------------------------------------------- -------------------M--YIRHEKI------------------------------------------- YRRDLELV--------AKRKK----------VKSAKRVRFGN-LKFLAVKIMITNKMKTSKISKLRTR---- ----------------------------IN------------------------------------------ -----------HVIKRKPV---EK--DTLDLSKLKMLK-MVPFKRQALPW-----RDPLPP----------- -----------RDIFD-----------------TFSG-----CIIY---TYS--------MLL-----LVS- --------L-PRL-PKGWPLRLLTGW------YWI-----YCILLVVAYRA-----SL-----TA-ILSKPV A--RL-----------------------TID-----KLKDLAESPIR-CG---------------------- -------------------------AWGEQ-------------NRLFF----Q------------------- -------------T----------------------------------AQ-DK--------PSMII------ ----------------GGKL-------------------------------------EHTPDPDA--A---- VERVV----------R-G-------N-F-A-YYDNVYSLKHLRS------------TRKSEKARQ------- ----TLHIMEEC-AVH-MP-------------------------------------------------ISIG LEKN-S-P-------------------------LKPKVDKY-----------VRALVETGLTKK-------- ---W---------------LADAI-------------EAF-------------------------------- ---------------QSNVELPPQEATMDLQKLTAAFIGLA-------------LGYGI-SLL----AFGVE KL---------------------------------YW----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----KCVIERDPAYDKYLTGTCH-----------RRVIRR------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR75d/1-579 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------M---------------------------------------------------------------- ---------------------DTTYAYV-------------------------------------------- ---------------------------------------------------------------YFNE----- ------SKDPEVKKLFL----KK------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------MKPFG----------------------------- -----EKAFTEPD----------VGM-----KRVRDEFY-----AFS------AE-VN-------------- ------------------------------------------------------------------------ ------------------------AAYL-----------------------------------------LIK ETF------------------------------------------------------TPQDV---------- 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------------------------------------------------------------------------ --------------------------------------------------------------------KYY- ---------------------------------------LGI------------------------------ ------------EDRS--------------------------------------DPIHDLFAKAN-Y----- ------------PFIKALMY-D----------------------L----N----------F----------- ------------T----LNMLQ------------VDS-GGWKI----------------------------- --------------------------------NG---------------T---F------------------ TG------------------------IMG---KF--------------QK-R--------------S---IE LGIL-----------------------------------------------------------GALMR---- -SDR---MEV--V-----------DY-TIVT-----MIVK----SSI-------------I-FKQ------- --------------------------------PPLSLV-SN---------------IYELP---FS------ ----------------------------------TGV--W-FSC-GGF-------VV-F---YW-----ITL VLFRLITKTEPF------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------T------------------------------------------ ------------------------------------------------------------------------ ----------------------------------VQE-----SLYY---MIG--------TIC-----QQN- ---------VELM-PHFNSAKLMFFF------AHL-----TSFFIFTSYSA-----SI-----VA-LLQSPS ---R------------------------AIT-----TVADLAASPFK------------------------- -----------AGSM----------DAIYAF--------------VYF----N------------------- -------------E----------------------------------SK-DP--------AVKEL------ -FQK-KMK-----------------------------------------PLGK----KAFTEADV--G---- MRRVR----------D-E-------F-Y-A-FSVEVNAAYLLIKETFTP--------------QDVCKVYE- -----LEAIK---LPP----------------------------------------------------FSIP VLKG-S-K-------------------------YRELLRQ-----------RLIWQREVGIIRR-------Y NLIWIA-------------------------------QKP-----------------TCES----------- --------------------GAAAFNSVGLNELRYVCIFMI-------------IGFGV-AFL----LLACE IA---------------------------------W-----------K-KQQN------------------- ------------------------------------------------------------------------ --------------------------------KRISKAKLKQ------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------QQSRS TLI--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------SFLN-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR75g.1/1-559 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------MQIV------------------------------ -------NISGEV-----------SH-----LDKMSSIRHDL------------------------------ ------------------------------------------------------------------------ -------------------------GL------------------------------------------VVD A--------------------------------------------------------SCDQT---------- ------EN-LF------------NV-MS--------------------RN---------------------- -----------------------SFF----------NA---------------S------------------ --------YEWLIFSR----------------------------N---------------TFNSSIR----- ------------------------------------------------------------------------ -----------------------------LLRRQ-------------------------------------- ----NLN--VD-SRVVLAE----------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------ETS-------------------- -----------------------------------------------SED---------------------- ---------------------FM--LFDVYNTLFRRN----GKF---------------------------- HVTLAGRW--------------------------------------------------NEERG--------- ------------------------------------------------------------------------ -------------------------FSIDCRQSL------------------Y---DRRHD----------- ----------FQNVA-MYVVFTD------------------------------------------------- -----------------L---------------------------------------K-RK----HNRTIL- ---------------------------------------ERL------------------------------ ------------ETNE--------------------------------------PLQDFALWRFS-H----- ------------HYVQMLMM-K----------------------H----N----------F----------- ------------R----VQYIT------------TPG-WGSQS----------------------------- -----------------------------TMAHK---------------T---S------------------ TG------------------------LLG---QL--------------KL-R--------------Q---VD LAVN-----------------------------------------------------------TLYVY---- -QDR---IAI--V-----------DY-SVVV-----AMHN----CRF-------------V-FRH------- --------------------------------PRRSNT-RI---------------TFLQP---FD------ ----------------------------------NSA--W-LGL-FTG-------LT-V---AG-----VAL ---FCAFRLERKFPW--------------------------------------------------------- ------------------------------------------------------------------------ -----NI----------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------SRTSQ---------------------------------- ------------------------------------E-----YLLT---ILG--------FIC-----LQG- ---------FAGI-TFLNASKVIIVV------MLS-----CALLIYQYYSS-----FI-----IGSLLTSPP ---R------------------------YLN-----TIRQLISSDLE------------------------- -----------VTIE----------NLFYLW--------------EFY----N------------------- -------------R----------------------------------TT-SP--------EVEEL------ -FQK-KIL--------TGS--------------------------------------ESSTDVIT--G---- IQKIK----------K-G-------G-Y-A-MQCDIGYAYPIIKRTFTD--------------DEICDLQE- -----IEVYS---KKP----------------------------------------------------LHLP LPKG-S-P-------------------------LKQFFRV-----------TLRKLIESGSGPY-------Y EREFFS-------------------------------QKP-----------------ACPRD---------- --------------------SLEQVAQIEVVQVVHVFYILA-------------MAMVV-CLI----LLVVE QI---------------------------------Y-YRF-------H-Q---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------RRERVA- ------------PYMS-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR75g.2/1-612 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----KGL---------------------------------------------------------------- ---------------------E-LWSFSTAST---------------------------------------- ------------------RTMVRY-LDM-----------------------------------GYV------ -------TR----VKVC----FKTSDI-------------LKLSE--------------------------- ------------------------------------------------------------------------ --------------------------RLSYSFSGKIHYVDIS------------------------------ -------NLTVTW-----------NH-----SHSMMSSYHLL------------------------------ ------------------------------------------------------------------------ -------------------------GA------------------------------------------TVD L--------------------------------------------------------QCPPV---------- ------SQ-LF------------DI-IS--------------------DH---------------------- -----------------------GYF----------NS---------------S------------------ --------YHWLLYGET---------------------------D---------------SRNSASC----- ------------------------------------------------------------------------ -----------------------------LLDEQ-------------------------------------- ----NLN--ID-AKVTLAV----------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------EIN-------------------- -----------------------------------------------RTES--------------------- --------GG----------YYD--LYDVYSTFRRRG----AKL---------------------------- NVTLVGNW--------------------------------------------------STGKS--------- ------------------------------------------------------------------------ -------------------------FQLASNQTE------------------Y---ERRID----------- ----------FGGIW-LKGAIT-------------------------------------------------- -----------------V---------------------------------------R-IV----HYETLM- ---------------------------------------EHL------------------------------ ------------TSDA--------------------------------------PVEAYALHRFG-Y----- ------------KIWELIMQ-K----------------------H----N----------F----------- ------------T----IKLLR------------TPA-WG-IA----------------------------- -----------------------------TSERD---------------S---H------------------ SG------------------------IIG---QL--------------AS-K--------------E---AD LAIN-----------------------------------------------------------TLTYT---- -KDR---ISI--I-----------DH-TVTV-----AMSK----MLL-------------V-FRH------- --------------------------------PKVTGN-RN---------------LFLRP---FE------ ----------------------------------VDA--W-MAV-LGV-------II-L---AS-----IVL FGNFCAESYKEYYDK--------------------------------------------------------- ------------------------------------------------------------------------ -----EV----------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------HDNRS---------------------------------- ------------------------------------L-----VFLT---VFG--------ILC-----QQG- ---------FSSK-TMFNSTRITLIS------TLI-----FSVLLYQFYST-----FI-----VGYLLIIPP ---K------------------------TMT-----TLQHLLDSNLK------------------------- -----------VIVE----------DLGYNI--------------DFL----N------------------- -------------Q----------------------------------TK-DP--------LATQL------ -YRS-KIL--------NGE--------------------------------------NSFLNVSE--G---- IARVQ----------Q-G-------G-Y-A-FQCDTAYAYPLMKRTFTD--------------KEICDLQE- -----TVLSP---FRQ----------------------------------------------------MHLP LPKG-S-P-------------------------FREMFRV-----------TVRKIVESSVGFY-------Q QKRFFC-------------------------------DKP-----------------KCAKS---------- --------------------ELEPI-DVGMDNVSSLF-----------------IGMLV-CLAGCVGLLLVE WI---------------------------------T-YSY-------F-K---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------GHGE--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR75h/1-625 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------MSRPSF----LIIVVFTLFQ-------------------------------- ------------------------TN---L--------LLLH-NFIRC------------------------ ---------------------------FDVSNLLQYSHKF----------------------------VLVS LT---------------------------------------------------------------------- --LWRKIFFVQ------IVQ---------------------------------------------------- ---------------------TSNLR----ENSSRKWESFRTTWSTNWVGILSTS---FRSHT--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------S--------VN---------------------------- ---------RELLDVCAKT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------KCFSTSF-------------------- --------------------HWVMM-NG-------------------------------------SVL---D ALGDVDLY---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------VDAE---IKVL-----VADGDDQL--KLYDV----YNNGKSLGGTLNVT FDRVVNVLP-SGEIT-FGRSIVD------------------------------------------------- ---------------------------------------------------------Q-KS----------K -----------------------------------YQNRNNLS----------------------------- ------------D------------------------------------------------ITLR-IGTRSR MFPSADASVSD--VLRFLES-YEKRNVDDVVRIGYMLTKALQKDL----N----------F----------- ------------D----IQYTH-------------------------------------------------- --------------------------YDLTSDD--------------------------------------- --------------------------AVG---VI--------------LD-K--------------Q---ID FSIA-----------------------------------------------------------GIRVL---- -NER---MEH--L-----------TS-V--------LFYMNYE-LAF-------------I-FKT------- --------------------------------PT---S--DNLLDS----------PFFRP---FA------ ----------------------------------PET--W-FTI-FLT-------I--L---VG-----SIV IKINHSLEV--------------------------------------------------------------- ---------------------HYQE----------------------------------------------- ---------------------------------------YLLGWT--------------------G------ ------------------------------------------------------------------------ -----------------------------------PP----------------------------------- ----------------------------------WFS-----ALVE---SLG--------HFC-----QQG- --------A-HLV-ARNLLGRLIQLV------IMTC----ALVVYNYYSSV-----IF-----LT-LIASPL M--SD------------------------IR-----TLSKLADSRLQ-------------------LGVE-- -----------DTVEA---------RDYFL---------------NSH----T------------------- ------------------------------------------------TN-GA--------LYLAR------ -KKFTDHS---------------------------------------------------WTSRNI--G---- LERVR----------R-G-------D-Y-A-YHCEKTDAFGWIRQN-------------------------- -----FDLQEVCDLNVLESMPPQP--------------------------------------------IGIL VRKD-S-P-------------------------FRELFTLR-----------FARMQEIGIVRR-------- -----------------FT--EFW------------------------------------------------ ------------ITKKPECFSESVVSSVSFEGSFALFLLLI-------------AGIVV-AFG----AFTVE I---------------------------------------------------G------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------LFRNIW- ------------------------------------------------------------------------ -----------------------------------------------------TRLNPEKLGIYKVT----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR75i.4/1-581 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------M-----------------------------------EFT------ -------KRELANTLIM----FSCDGLD------------YKL----------------------------- ------------------------------------------------------------------------ ---------------------------LGQNFVGSIHHFQMN------------------------------ ------------------AERFYNDH-----ERFMTVGHYRL------------------------------ ------------------------------------------------------------------------ -------------------------AV------------------------------------------VAD L--------------------------------------------------------SCDYS---------- ------HE-LM------------IF-CS--------------------EN---------------------- -----------------------EYF----------NG---------------S------------------ --------YRWLLFSEF---------------------------N---------------M-SKTMD----- ------------------------------------------------------------------------ -----------------------------SVRKQ-------------------------------------- ----NLN--ID-SRVTMVV----------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------ETI-------------------- -----------------------------------------------EEN---------------------- ---------------------FE--FYEIFGTVRRRG----GST---------------------------- HVMKVGSK--------------------------------------------------TKNSG--------- ------------------------------------------------------------------------ -------------------------VVWTCTTNS------------------Y---YVRDN----------- ----------LGGVTLLGAVAT-------------------------------------------------- -----------------L---------------------------------------G-FN----KQLTVK- ---------------------------------------ENM------------------------------ ------------RSLQ--------------------------------------PPTNYIGSRMC-Y----- ------------QIVQLLKR-R----------------------L----N----------F----------- ------------R----TQHFI------------VPD-FG-FD----------------------------- -----------------------------LIGTN---------------S---S------------------ NG------------------------VVG---KL--------------QQ-N--------------L---ID LGFS-----------------------------------------------------------PMAVT---- -KER---LGV--F-----------DQ-TVPI-----ATVR----ITI-------------I-FRH------- --------------------------------PKSGGT-RN---------------LFLQP---FD------ ----------------------------------NQV--W-TLI-GAV-------LL-V---ST-----GIL SVILYVKQRKSRFH---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------C---------------------------------- ------------------------------------K-----YTLI---VFG--------IFC-----LQS- ---------YSGR-ISIIPSRITLIT------VIL-----FSILLYQFYSC-----FI-----IGYLLVLPP ---K------------------------NIR-----TLEQLLASNLK------------------------- -----------LSVE----------NISYNH--------------DFL----K------------------- -------------R----------------------------------TN-VD--------VIHDL------ -YER-KVL--------SHE--------------------------------------FGFTNVSM--G---- ISLVK----------R-G-------G-Y-A-FHCDNSYGNTFIMRTFSD--------------HEICELQE- -----MSLFP---PRA----------------------------------------------------VNLN VPKG-S-P-------------------------LKEIFRV-----------TLRRLLEIGLAEY-------Y QRKLFM-------------------------------KRP-----------------PCLKQ---------- --------------------NTASV-QVRLEDIGDLCILLM-------------IGVSI-SIA----ILMVE IV---------------------------------E-YRV-------R-K---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------YWE---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR75k/1-580 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---MQDG----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------C------------------------------------------------ ------------------------------------------------------------------------ -----------------------------WTDHEKTFFW--------------------------------- --------------------------------RELASIP----AAVR------FSGLDVGDL---------- --------------------------------------PW-----------DDPNQ---------------- -----------------------HRNLL-----------------------------------------VVD AS--------------------------------------------------------CPGT---------- ------KR-LL------------QQ-AG--------------------Q----------------------- ------------------------LL----------YY---------------R------------------ --------VKWIVID------------------------------------------------RGSL----- ------------------------------------------------------------------------ --DCGRFLR--------------------FFDGL-------------------------------------- ----KVL--IS-SEVYYLC----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------AGEGV-------------------- --------DG-----------YS--IRQVYRYSIESS----LAE---------------------------- --EVYGYW--------------------------------------------------YRG----------- --------------------------------------------VVVRND---------------------- -----------------------------HAAIA------------------AS--VRRQN----------- ----------LNRFK-LRASVV-------------------------------------------------- -----------------I---------------------------------------T-HN-------ATL- ---------------------------------------NHL------------------------------ ------------EDYK--------------------------------------EKHVDTITKKN-Y----- ------------FLTKYMIE-N----------------------L----N----------A----------- ------------T----VQYSY------------VNS-WGYRN----------------------------- ------------------------------PKTG---------------R---F------------------ SG------------------------MIG---EL--------------QA-D--------------Q---AD LGAT-----------------------------------------------------------ALFLT---- -ADR---IRE--I-----------DY-LSMT-----TPTR----AKF-------------V-FRS------- --------------------------------PKLSVT-DN---------------VFILP---FN------ ----------------------------------GTV--W-MCI-ISF-------IV-L---SA-----TLL LIIMLVEF---------------------------------------------------------------- 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HSMLYT-------------------------------KKP-----------------TCS------------ --------------------GGSSFIPVTIVDVWPALVLLW-------------WGFGI-AAG----LVVGE -------------------------------------FGL-------K-KRRD------------------- ------------------------------------------------------------------------ -------------------------------------IRGR------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------FFKR--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------SR--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR75l/1-585 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------MSC------------------------------------------------ ------------------------------------------------------------------------ -----------------------------WGETDRLEVFK-------------------------------- ------------------V-----LN-----ERYLTCFV--------------------------------- -----------------------------------------D-DHISRFV-EDIND---------------- -----------------------HQTFL-----------------------------------------VVD LA--------------------------------------------------------CPGT---------- ------KQ-LL------------KS-AG--------------------L----------------------- ------------------------LL----------FM---------------K------------------ --------YRWLIVNSKFFVE-----------------------D---------------HP-SEED----- ------------------------------------------------------------------------ --QVQFFEQ--------------------SLADL-------------------------------------- ----SLL--VS-SEIFIFI----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------KQTA--------------------- --------NN-----------FS--VNQIFKHFELAP----FKV---------------------------- --ELFGSW---------------------------------------------------------------- ------------------------------------------IDGGFKDK---------------------- -----------------------------RNERV------------------TS--VRRLD----------- ----------LQGHT-LQASMV-------------------------------------------------- -----------------V---------------------------------------T-NQ-------ETL- ---------------------------------------QHL------------------------------ ------------TDYK--------------------------------------EKHIDTITKVN-Y----- ------------ILTNCLAA-Y----------------------M----G----------A----------- ------------A----VNYSV------------VST-WGYLN----------------------------- ------------------------------TTTG---------------R---W------------------ DG------------------------MIG---EL--------------SQ-L--------------R---AD LGAS-----------------------------------------------------------PLFFT---- -SDR---IAV--I-----------EY-VAMT-----SATR----SKF-------------I-FRS------- --------------------------------PKLSFT-EN---------------VFLLP---FD------ ----------------------------------DLV--W-MCI-GGV-------VL-L---SS-----GLL VITGLAEW---------------------------------------------------------------- --------------------------RVP------------------------------------------- ---------------LTVDD----------------------------------------PADAT------- ------------------------------------------------------------------------ ---------------------------------ILRPS---------------------------------- ----------------------------------FRD-----TLLV---IYG--------ATC-----QQG- ---------ASIL-PRSFAARTITLI------AFL-----VLMFLYGCYSA-----NI-----VA-LLQSPS ---T------------------------KIR-----TLEDLLASRLK------------------------- -----------FGVH----------DTVFNR--------------YYF----T------------------- -------------H----------------------------------AS-EP--------TRQAI------ -YER-KIR----QPDGS----------------------------------------QSFIALEQ--G---- VDKIR----------N-G-------L-Y-A-FHVEQGVGYKVISETYQE--------------DEKCGLQE- -----VQYLQ---VID----------------------------------------------------PYYA IQKN-S-S-------------------------FKEHVKI-----------GLFRLNEHGIQFR-------E NANLYT-------------------------------KKP-----------------KCTG----------- --------------------GGGKFVPVSLVDTEPAILVIV-------------WGAGL-SAT----VFTAE LL---------------------------------W-WKV-------Y-RW--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------FQD--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------WKG-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR75m.1/1-454 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------MQRGLISEEI-AI----------------------WCNG--------------- --------------------------------------VIDD-RRAGRSV---------------------- -------------------------------SV--------------------------------------- -RRKNLH----------------QLPLR-------------------------------------------- ------------------------TTLL-------------------------------------------- ---------------------YTDTF----------T----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------L---------------------------- ---------DHFDD---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------YENPQIDTPNRL-------------- ----------------SYLMINSLYRIY-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------L----N----------A----------- ------------T----FV----------------KR-YST------------------------------- -------------------------------------------------T---WC--------YPNPKT--- GG------------------------LIGVCVDL--------------IN-N--------------H---SE VG-A-----------------------------------------------------------FMFIT---- -TSR---LKM--M-----------DF-L-PL-----GMEGT---LSF-------------I-FKA------- --------------------------------PKLSIM---------NN-------IFELP---FD------ ----------------------------------PNV--W-VCLFSLV-------FV-----LG-----VTF YLMTKLND---------------------------------------------------------------- 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---------------------REF------------------------IMIRLKAQLSCVK--GTDFQ---- --------------------------PLSVVDVRFAMEVIG-------------VGLLG-TLL----VLAAE V---------------------------------GWS-RY---------QYNRLP----------------- ------------------------------------------------------------------------ ---------------------------------VFEYVE--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR76b.1/1-487 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------ME-K----------------------F----K----------F----------- ------------N----YTLVM-PEH---------NI-VGSS------------------------------ -----------------------------DDMDG-------------------------------------- -S------------------------IIE---LL--------------AN-E--------------K---AD IAVA-----------------------------------------------------------FLPIL---- -ADA---RQH--I-----------LY-S-TG-----LDEGE---WMM-------------I-MIR------- --------------------------------PLE-SA--SGS-------------GLLAP---FD------ ----------------------------------RDV--W-ILI-LVS-------LL-A---VG-----PII YGLLVI------------------------------------------------------------------ --------------------RYYL-T---------------------------------------------- -----------------------------------------------------------KD----------- ------------------------------------------------------------------------ ----------------------------------SEQV-RY------------------------------- ---------------------------------TLPH-----CIWF---VYG--------ALM-----KQG- --------S-TLS-PTGDSTRILFAS------WWI-----FITILTSFYTA-----NL-----TA-FLTLSK F--TL-----------------------PIN-----NAEDVRR-----------------------KEKN-- -----------FVTIR---------GNAIE---------------YAI------------------------ -------------K----------------------------------NS-DE--------ALNSL------ -SVLVDKH---LVE--------------------------------------------FTTNLND--S---- DILMT-------TVAK-K-------N-Y-V-YVRDRPAIEHLVYNDYLVRR-----KVNPINERSHCP---- -----FATATTP-FLK-RV-------------------------------------------------RAFA YPNS-T-R-------------------------WNALFDPQ-----------LLNMVEGGLIKF-------- ---K---------------LLENL-------------PK-------------A---EICPQNLGG------- -----------------------TERQLKNRDLVMTYLVML-------------TGFCT-SIA----VFFSE MF---------------------------------A--RI-------M-N---------------------- --------------------ER-------------------------------------------------- ------------------------------------KLAKELKEL----------------------NGPGL KLPPEKI---------------------------------------------TYL----------------- -------------------------------------------------------SKGVS------------ --------DSPPPPYAEIFSRHT------------------------------------------------- ----------------SGMI--------GAKGMFGSQIVTDGDAARQMI---NGRDYM-------------- ------------------------------------------------------VVKEKNGIGSQLI----- ------------------------------------------------------------------------ ----------------------------------------PMRAPS-------------------------- ------------------------------------AAIFQYTYTN-------------------------- >CquiIR8a/1-887 ------------------------------------------------------------------------ --------------------------------------------------------------MRH------- ----------------LVLSCRTER----------------------------------------------- ------------------------------------------------------------------------ -------------------------MIVHEREQQNV------------------------------------ --------------PALASRAIRSFL-----------AQTKG----------------------VSVF---- --DYYIAYNRDHVIFND--NMELCSAVQ--------K-GATFLL---------------------------- ---------------------------------------------------------------------DFT WTD----------------------TNRIMSAADNFNI-----------------PYIHADAS--------- -------------------PQTFLK--------VMETY---LRA-RG------ANDV--------------- -----------------------------V--------YIFD-SPEN------------------------- ---------------------------AD--MAIYFLITES-----------------------QLRTIIFD -------------------------RLSDNA-----------IERIKSVRPYP-SF---------------- --------FAI-------IAN--TSQMG-------------------------------------------- -----------------------VLF-----------RRA------------LQG---GLVS---------- ----KPD--KWNLI----------------------------------------------FMDVET------ ---ESFEHHETFPAMS----RLLVEKSTCCML-LNMEDGCT---------CPVE------------------ ------------------------------F----------------------------------------- -----------KPWEAHLE----N--------------------------------VVQKV-L--------- ----QQALHD--------------------------------------------QLPLVTQEDCS------- -VV-------GSSATADIS----------------------------------------------------- --SLLRDLRADERFW------------------------------MPDGSRMLR------------------ -------------------YNLNVSI--------WS------STE-----------------------EDEA EAIRVGSI--------------------------------------------------AKGV---------- ------------------------------------------------------------------------ ---------------------------VVPSEGN------------------------RIK----------- ----------ATKRY-FRVGTTE------------------------------------------------- ---------------------------------------------------------S-IP--------WAY ------------------------------------------R-----QRDPQ------------------- ------TGEIILDE-A-------------GQ---------------------------PIWEGYC-I----- ------------DFLRQLSK-V----------------------M----S----------F----------- ------------D----YDLVW-PKK---------GT-FGM------------------------------- -----------------------------RDKAG---------------N---W------------------ DG------------------------LIG---DL--------------VV-G--------------E---ID FAMA-----------------------------------------------------------SMKMT---- -AER---EEV--V-----------DF-V-APY----FEQTG---ILI-------------V-MRN------- --------------------------------PVR-ET--SLFK-------------FMTV---LR------ ----------------------------------LEV--W-LSI-LLA-------IV-A---TA-----VML WLLDKF------------------------------------------------------------------ --------------------SPYS-AKN-------------------------------------------- -----N------------------------------KQAY-----------------P-------------- ------------------------------------------------------------------------ ----------------------------------YECR-DF------------------------------- ---------------------------------TLKE-----SFWF---ALT--------SFT-----PQG- --------GGEA--PKALSGRTLVAA------YWL-----FVVLMLATFTA-----NL-----AA-FLTVER M--QT-----------------------PVQ-----SLEQLSRQS----------------------RIK-- -----------YTVVK---------NSDTH---------------DYF----K------------------- -------------NMKNAEDVLYQMWRNLTLS---SGNDQAQYRVWDYPI-KE--------QYINI------ -LSAIESA---KP----------------------------------------------VDSAEA--G---- FKRVNERLEA-----D-----------F-A-FVHDSAEIKY--------------------EISRNCN---- -----LTEVGEV-FAE-QP-------------------------------------------------YAIA VQQG-S-H-------------------------LQDELSFY-----------ILELQKERYFES-------- ---L---------------TAKFW-------------NN-------------S-MRGVCPNTDD-------- ------------------------SEGITLESLGGVFIATL-------------VGLAL-AMV----TLAGE VL---------------------------------YY-RR-------K-D-RQT------------------ ------------------------------------------------------------------------ -----------------------------------KLVQV---EPA-------------------------A AETPNNKSK--------------------------------------------------------------- -----------------------------------------------------KEKQQSLNFKN-MLN---- ---------LDPKN---------------------------------------------------------- ----------------------------------------------NLN---KVVDKNIP------------ ---------------------------------------------------KEITIGSKFVPASE------- ------------------------------------------------------------------------ ------------------------------------------KQQKIS------------------------ -------YISVF----------------------PRN-PIH------------------------------- >CquiIR92a/1-663 -----------MLP--------------------------------------IVHQDGDL------------ ------------------------------------------------------------------------ ---------VG------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------LLQY-------IVLTYFV-------------------------------- ------------P----------TSYC---------TVVFYD-HELTNGS---------------------- ------------------SPCDRHCQLLD--AVDTALLEGFRQYHAVMW----------------------- -------------------ISAGLESAEQDI--------------------RDAVEFGC------------- ------QSYIVV-----------SQQLM-------------------------------------------- -----------------------QFFD---------LKLV-----------IKES---TLQRIRD------- --------RNFLILDVTES-----------------------------------------LFDADSW----- -----------------------------------------------------------------IT----- ------------------------------------------------------------------------ ---------KEAFKCTYIS----------------------------------------------------- ----------------------------------------L------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VXNHLLILNLAVYPNLWLWS-----------------------------SLENGS HEFYTQDY---------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------S------NSYV-NELELVTTWN----------- ----------SSSAH-SALAD--------------------------------------------------- -----------------------------------------------------------IL--------FHD ----------------------------K------------LY----------------------------- ---------------D-----------LQGR----------------------------------------- ------------TIPMGVAE-Y----------------------A--------------PY----------- ------------C-------------MT----------TNV------------------------------- -----------------------------GAGNG---------------N---------------------- AD------------------------AFN---ST--------------AS-K--------------EL-YVE GLEG-----------------------------------------------------------SQIVE---- -FCQ--------------------NH---GPSDWGDIFENG---SGYGE-IYS-------T-YMKETEFATC CLYYNWYLHLLDGSQYVAKSTITVLVPGSKVLPTS---------------L-----TLIYP---FE------ ----------------------------------NTL--W-KAI-AFM-------LV-L---MT-----AVH HMITA------------------------------------------------------------------- -----------------------L------------------------------------------------ --------------------------------------------D------------PNSP----------- ------------------------------------------------------------------------ --------------------------------QPPFDK---------------------------------- ------------------------------------------SIFD---IIS--------IYL-----DQG- --------V-FPN-SHSSAYRFLVSF------ILL-----SGVVLSNSYTS-----GF-----AS-VLTIPR Y--GK-----------------------SIE-----TIHDFV-QTPYRWG---------------APAIA-- -----------WVLSL----FGA----------------------DSF----K------------------- -----------------------------------------------ISDPF-------------------- ---QHDIQ---TV---VRKF-------------------------------------DMTPDEEQ--L---- YRRSL----------S-G-------T-Y-G-LGVELLNGGNFAFGSFIR--------------EDNVRT--- -----FEILKQE-LYY------------------------------TY--------------------TIGY AQRG-W-P-------------------------LMEYYNKF-----------NLESIQHGFLIY-------- ---WEG-----------RTARKWL-------------NN-------------RIQQALTEISAGHNEG---- ----------------------EELAPLTVQYIVGPLWVLA-------------FGLSA-AFG----MFVCE IG---------------------------------WK-KL-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------AG----------------LWRKVT- ------------------------------------------------------------------------ ----------------------------------------------------LKRANR-------------- ---------------------------------------------------RLFDFVS-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >CquiIR93a/1-840 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------MAAVILD------------------------------------------- -REYLDNQ--YEALLENTKRTFEQIL-------RDN---FKN--------------------GGLIVKYFSW --TSI-NLRR-DFTAVL--SVSNCENTWDVYRNAAKE---NLVIMAITD----------------------- --------------------------------------------------------------------TDCP R----------------------------LPSHNAIMI-----------------PKSI-PASGI------- -------------------FEELPQ--------VIMDMK--TMKAFS------WKSAI-------------- --------------------------------------LLYD-DSF-------------------------- -----------------------DRDIVA--RSVLALSK--ESEDVL-----------------PLSLSLFR IESHT----------------HMW-EKRKAV-----------RKVLLGL--PTRY--IG------------- 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----------FRGIH-LNFYTYH------------------------------------------------- ---------------------------------------------------------N-PP--------WQF -----------------------------------------VS----------------------------- -----------FNE-S-------------GHP--------------------------TLSGGVV-M----- ------------DILEELSR-K----------------------L----N----------F----------- ------------T----YTVIV-------------------------------------------------- -----------------------------AQTNI---------------E---Y------------------ VGNLTEDGNNTSIREIHTVTTDIPSEIMK---SL--------------ID-N--------------K---IL LAAV-----------------------------------------------------------GATVS---- -EKQ---KKF--I-----------NF-T-VP-----ISIQT---YSF-------------I-VSR------- --------------------------------PKE-LS--RVF-------------LFLSP---FT------ ----------------------------------VDT--W-MCL-GLT-------IL-M---MA-----PLL YVVNRV------------------------------------------------------------------ --------------------SPFY-E---------------------------------------------- ---------------------------------------H-----------------HGKS----------- ------------------------------------------------------------------------ ----------------------------------NKLG-LG------------------------------- ---------------------------------KLNN-----CFWY---LYG--------ALL-----QQG- --------G-LYL-PYADSGRIIIGT------WWL-----VVLVIVTTYCG-----NL-----VA-FLTFPK I--AV-----------------------PIT-----TISQLVRNN---------------------EGIT-- -----------WSIRK---------GTFLE---------------QFL----R------------------- -------------E----------------------------------TD-DA--------KYLKL------ -SHGATFI---SD------------------------------------------------ESDS--M---- VQSIR----------N-G-------H-H-V-HIDWRTNLKYLLKREFLK--------------NDRCD---- -----FALSLDE-FLD-EQ-------------------------------------------------IALA LPKA-S-P-------------------------YLDVINAE-----------ITKMHQFGFIHK-------- ---W---------------LSNYM-------------PS-------------E---DKCSKARKNT-D---- ----------------------VENHTVNNDDMAGSYYVLL-------------IGFSS-GMF----LFLIE FG---------------------------------WR----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------FYK--------------------------- ------------------------------------------------------KSK--------------- ----------------------------------------------------EQSLQ--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------P--FTD------------------------------ >Csap_11092368/1-465 ------------------------------------------------------M----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------SVP------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------P--------RQ---------------------------- ---------P-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------D----------- ----------LTGLH-IRCVVEE------------------------------------------------- ---------------------------------------------------------W-PP--------FIM -----------------------------------------VN----------------------------- ---------------T--------------------------------------EGEETQLTGVF-F----- ------------ELWTILQG-R----------------------L----N----------F----------- ------------T----YEWRH-SPD---------GE-WGV------------------------------- -----------------------------VAPNG---------------S---W------------------ SG------------------------MIG---QL--------------VR-G--------------N---AD VILG-----------------------------------------------------------NVDYT---- -SER---ARA--I-----------DY-V-VP-----LVYSS---FRL-------------L-VRQ------- --------------------------------PTS-P--IGGWS------------SYSME---FT------ ----------------------------------AST--W-AGL-LLT-------AC-L---CC-----IVL TLVLRL------------------------------------------------------------------ --------------------A--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------SGEQ---Y------------------------------ ---------------------------------AARE-----AVLI---VIG--------CLC-----QQG- --------P-VRE-EKRSSVRIVLLT------VGV-----LGVVSVTHYSS-----VM-----IS-FLTLTT T--TH-----------------------SIA-----SLTDLLDSST--YT---------------------- -----------LGIAR---------GTSTH---------------DII----Q------------------- -------------A----------------------------------SQ-GE--------LYRRV------ -WSELLAP---HP------D-------------------------------------SLVATIDE--G---- VQRAN----------R-Q-------N-F-V-FLIDENFYLSRYTRH--------------------CS---- -----LTLVGPR-YLK-VP-------------------------------------------------SSFT FRKN-S-S-------------------------YKLIFDHE-----------LINMMEAGLLER-------- ---E---------------LRHKQ-------------AR-AM----------------CENESIT------- --------------------------PIGFHSTFTALLLLG-------------AGLLL-SLL----FLLIE RL---------------------------------VF-RY-------T-DQAGGV----------------- ------------------------------------------------------------------------ -----------------------------------QSSFAPPAR----HSDTG------------------- ----------------LR------------------------------------------------------ -----------------------------------------------------QCDVAPLAVTA-------- ------VMGGTTPS---------Y-LGPGV------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------TRVP---FSSRSGHR--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap_11255891/1-661 ---------MWKWSG-------------------------------------QL------------------ G----------------------------------------------------RFMVLLVPLLLVHTPTTLE A----------------ENYTTTTGSTS--------------P--------------------------RPA VAR-------------------------------------------------------------------SS QLARPL------------------------------------------------------------------ ------------------------------------------------------------------------ -------LHHFPSN-I-------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------SSLQKAEALT--------------------------AA------- ----------------------LMR--------FILEV---SSGR----------QVY-------------- --------------------------------------LLGD-NSM-------------------------- --------------------PEVGV-AAR--VC----GEARVD------------------------TILLT Y--------------------------EPRL-----------LLLESLIR-SPLRPLDV------------- ------RYVVV-------MCT--ADHVL-------------------------------------------- -----------------------HVF-----------QQV------------RAK---ALES---------- -----LT-VWWF-V----------------------------------------------VTTEDRT----- ------------------------------------------------------------------------ ----AALQDL--------------------L----------------------------------------- ---------REGSQVTLIT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------RRSND-------------------- -----------------AV--FTLATTRV-------------------------------------NQAGMV RLEAAGKW---------------------------------------------------------------- ---------------------------------------------RPASR-RAGNA---------------- ----------------------------SDWSAT-----L------VPDH-LHL----YAD----------- ----------FGGRQ-LIVAAND------------------------------------------------- ---------NW-------------------------------------------------P--------FLG -----------------------------------------LT-----L----------------------- ------------LE-G-------------N--------------------------TAAPRSGID-I----- ------------NILDALGA-K----------------------L----N----------F----------- ------------T----YQLVV-PRD---------RA-WGG------------------------------- -----------------------------PQPDG---------------S---V------------------ TG------------------------LIG---MV--------------AR-H--------------E---AH VAIC-----------------------------------------------------------EITIT---- -DTR---ETV--V-----------DF-T-AT-----YWLES---LTL-------------V-SRA------- --------------------------------PKE-KE--RSM-------------AVFWP---FT------ ----------------------------------TAV--W-GFI-AAA-------TL-V---MG-----PV- ------------------------------------------------------------------------ ---------------------AWV-VMR-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------ASGVNL-PLHV-----AAFN---MFR--------NIV-----IQG- --------N-FLP-LKSTSLRFVLIS------WYY-----FCFIIYAMYSG-----TL-----TA-VLAIPS F--DR-----------------------PVD-----SLTDLPAAVAN-------------------GFAV-- -----------GTLKA---------SSTEF----------------LF----R------------------- -------------H----------------------------------AD-GG--------IYKQV------ -WELF-----------HPVH-------------------------------------SLLPDPEL--G---- FDKVL----------E-E-------K-F-V-LVNSELNAKIRA----TV--------------RGREK---- -----YYFGRDT-FYP-HG-------------------------------------------------YGIA CTSG-A-P-------------------------FRPKLEQL-----------LQWVVEAGLVTQ-------- ---W---------------GEQEI-------------QK-------------L---AHYEVGSDKAQ----- -------------------AM----LSLTLEHLQAAFYLIL-------------SGSTV-AAA----TLMME L----------------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------SVCVLLNKDS----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap_1193996/1-699 ------------------------------------------------------MNIT-----------EKD Y----------------------------------------------------QLFTQFFILFASFGTVYIC S-------------------AN-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----ADMAWNRHSVV-------------------------------------------------------- ----------------------------------------TSSHLEGATDIRT------------------- ------------------------------------------------------------------------ VSYSLNHGD------------------------KEVRI-----------------P---------------- --------------------MELVF--------FLMKQ---TSSH----------HIY-------------- --------------------------------------IIYD-NSF-------------------------- --------------------SGVKQ-LIE--GV----FLSKMD------------------------AMVME Y--------------------------DIIL-----------SDINSILR-ISHPSLFE------------- ------YHVLL-------FCS--SNHTI-------------------------------------------- -----------------------TFF-----------EKI------------RQL---YLVS---------- -----SR-QKWI-V----------------------------------------------TSVVDIS----- ------------------------------------------------------------------------ ----NSLQEV--------------------L----------------------------------------- ---------TEGTQVVLVI----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------PASS--------------------- -------------------DYFQVLVSNV-------------------------------------HQTNEV RFKKAGVW---------------------------------------------------------------- --------------------------------------------SHTSQS-SLDRI---------------- ---------------------------------P-----L------FPDL-LDI----YEN----------- ----------FRGRE-VVVATID------------------------------------------------- ---------NW-------------------------------------------------P--------FFQ -----------------------------------------LR-----Y----------------------- ------------LP-D-------------G--------------------------TPEAYQGID-Y----- ------------NVIDSISH-Y----------------------L----N----------F----------- ------------T----YRVVE-PPD---------GR-WGG------------------------------- -----------------------------VRPNG---------------T---V------------------ YG------------------------MVG---MV--------------AR-F--------------E---AH VAID-----------------------------------------------------------EITIT---- -DVR---ESV--V-----------DF-T-QP-----YFLES---TTL-------------V-SRA------- --------------------------------PEE-RP--RSL-------------AVFYP---FT------ ----------------------------------YPL--W-LLL-VMV-------TF-L---MG-----PLG FLF--------------------------------------------------------------------- ---------------------TLG-HNYCIH----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------GPSTRA-----ENSFH-----------K SDVPGDVGIDQKNIHPFNEHQFPHK----KSIFVVSW-----YCFN---MFR--------SVV-----IQG- --------N-RLT-ARSWPMRLLLFS------WFT-----FCVILYALYAG-----TL-----TA-YMTKPS F--EK-----------------------PID-----SLQDLLEANKF-------------------GFVP-- -----------AAQAG---------TSNEY----------------LL----K------------------- -------------T----------------------------------AQ-SG--------IFKAL------ -WEMT-----------ESSR-------------------------------------SFPKSGHE--A---- MEKVL----------T-D-------N-I-V-YMSANLNSEIRA----SQ--------------KGRHR---- -----FHLARNT-FFP-QG-------------------------------------------------YGIA CFPG-A-P-------------------------FKRKFNTM-----------LGRMNQGGLVNK-------- ---W---------------VRDEV-------------GK-------------L---RSINDENAEDEGKLLY ------------------ILKKAAARSLTLDHLQGAFFILA-------------TGGII-SVL----SFLTE TF---------------------------------KL-Y--------------------------------- ----------------------------------------------G------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap_1421470/1-662 ----------MC---------------------------------------RMVM------A---------- -------------------------------------------------WWR-AVIMAAVMVMAAAVIADRP ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------LMQMIRDVIR---------------------------------- ----------------------LRQW------NHVVLLDP-------------------------------- ------------------------ADSEIL--------SPQE-TV--------------------------- ---------------------QLLADIVH--SA---------------------------------AGSIIP LTSSDTFALGLY----------------HSIA---------TSNTSQGGADGGADIERVMYLR--------- -DPRYRSQFIA-------QWD--EAGLT--STFMTMAGKL-------------------------------- -----------------------GFY----------TE----------------K----------------- --------QEWLVL----------------------------------------------LSKNVSL----- ------------------------------------------------------------------------ ---Q-QVK--------------------DDLADV--------NI---------------------------- ---------YVDGEVMLC------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------LETVESNF------------------ -------------------EIIEVWNVGR---------E---------------------------TGSHTL LQETWGFW--------------------------------------------------TPATGLR------- ------------------------------------------------------------------------ -------------------------------QIT---L-K------NKYD-R------RKD----------- ----------LQGFH-LRVATIE------------------------------------------------- ---------------------------------------------------------T-MP--------YES -----------------------------------------LM----------------------------- ---------------E-------------------------------------NGTLQNFYEGYV-V----- ------------DVWHTLQE-Q----------------------L----N----------F----------- ------------T----YT----ATD---------TL-FGS------------------------------- -----------------------------LQKDG--------------HT---W------------------ NG------------------------MVG---ML--------------QT-D--------------D---AD VAVA-----------------------------------------------------------PLSIT---- -EIR---SLS--I-----------DF-T-IP-----IQIVS---TRL-------------Y-IRR------- --------------------------------PVL----EGTWT------------LYGQP---FD------ ----------------------------------MYL--W-LTI-PVS-------IL-V---CA-----AAL WLFNSV------------------------------------------------------------------ --------------------TVH------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------LGVNE-HFI------------------------------ ---------------------------------SASQ-----AFWM---IFS--------GII-----QQS- --------T-SAE-PGPVSGKIVFFS------GLW-----MGLVLLTCYSA-----IL-----VS-ILTTRE P--QL-----------------------PFK-----DFEGLLEHPN--WN---------------------- -----------LGVRT---------NTALA---------------DSL----A------------------- -------------L----------------------------------APVGS--------PMRMS------ -WDKMVGK---DP-----IK-------------------------------------NLPNNNDD--A---- LASVL----------Q-G-------K-Y-A-FFANKEYIIYRLQRKLPV--------------QQAMD---- -----IVDTNTD-FLR-RG-------------------------------------------------IGFG LQKR-S-P-------------------------YRRLFNHV-----------LSKMTQKGHLNR-------- ---L---------------KRKWW-------------PNINR----------------NPEKAYP------- --------------------------TPGFKEVFTVFIILG-------------GGIIC-ALA----FLLIE CL---------------------------------VC-DY-----------SSSS----------------- ------------------------------------------------------------------------ -----------------------------------SSSEQST------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------SPSLF-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap_1511681/1-586 ------------------------------------------------------------------------ --------------------------------------------------------MVAFSLTSVTTLWWAA S--------LG------LGVASNS--------------------------HGLPNVLAQSNAEGSAGFHIPA SPA--------------------------------------------------------------------- ------------------------------------------------------------------------ -----------------THDAITTTS-------PFSQTRS-------------------------------- ------LTRPRPQE---------------------------------------------------------- ------------------------------------------------------------------------ --------------------------RRESEKFRELLV-----------------PS---HRLSEER----- --------------GAHHYLSSLTK--------YLTHG---TYEN----------KVM-------------- --------------------------------------LVWK-KSL-------------------------- --------------------SD----ATR--EA---ESEGQGN-------------------GPASATEALG V----EVRSCDT----------DS-L-HDRL-----------RVLSNLVPSGGPHHQTL------------- --------VIL-------LCR--QTNMT-------------------------------------------- -----------------------GVV-----------EMVG--------RATRGK---GGER---------- -----GG-GEGR------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------G----------------------------------------- ---------EEGGEKIIIL----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------SLDTDT KHERTTRWEEF-------QDGNESD----------------------------------------------- ---------------------------------------------ELSRE-SRSYSYLK------------- ----------------------------AMSSNP---H-S------LPP----------TD----------- ----------FQGET-FKVSAVD------------------------------------------------- ---------NW-------------------------------------------------P--------FFG -----------------------------------------LR-----K----------------------- ------------GA-G-------------G--------------------------RVEADAGID-V----- ------------SILNTLSQ-T----------------------L----N----------F----------- ------------T----YEVVL-EEG---------GQ-WGG------------------------------- -----------------------------PQADG---------------T---V------------------ TG------------------------MIG---MV--------------AR-G--------------E---AH LAIN-----------------------------------------------------------EITIT---- -AAR---ETV--V-----------DF-T-RP-----YFMES---SAC-------------T-SPA------- --------------------------------PKE-RS--RAF-------------AVLSP---FT------ ----------------------------------LQV--W-LSV-GVS-------VM-A---VG-----LVL WVV--------------------------------------------------------------------- ---------------------SKL-IGQ-------------------------------------------- ---------------------------------------Y-----------------REES----------- ------------------------------------------------------------------------ ----------------------------------LVM----------------------------------- ---------------------------------PLHN-----MTFN---MYR--------SLV-----VQG- --------N-RLP-ALLWPLRLVFAG------WYL-----YCFYVSALYSG-----TL-----TA-VLALPV Y--EK-----------------------PID-----SLADLLEASKL-------------------GFYP-- -----------VTIKE---------ISIDF----------------LF----Q------------------- -------------K----------------------------------AT-SG--------IYHQI------ -GRLM-----------TSDK-------------------------------------HYVDSPSN--G---- IATVL----------Q-G-------P-A-V-YIDARLSMEIQM----II--------------QGR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap_1522139/1-827 ------------------------------------------------------------------------ ------------------------------------------------------MCSVLLLLSLVSSSQFVT GN-------IG-----DMTRATTTTTTTGTTGILGFICFSWLPMILAVSQLQMPSNTPKPSSS-----HKPV PHT--------------------------------------------------------SALTPLLT----- H----------------------------------------------------------------------- ---SKTPDLLASHTHVFHQHLISLPP-------VLRASHTPGSP---------------------------- -------SHLSPADA-------------------------SPVHSNTRARSLIA------------------ --------------------------------------------------------------------RETR ATTHPQPHV------------------IHSSTHSHASV-----------------AS----PLPA------- ----------------------LLA--------WVWRWA--APPS----------SLL-------------- --------------------------------------LLFD-HTA-------------------------- --------------------KGTGT-LQE--VL---REESWTS------------------------LWVLG Y--------------------------TEDL-----------TPLKNILLKRSFSLPPS------------- ------TAVLL-------LCS--PTNAS-------------------------------------------- -----------------------TVF-----------SFV------------REH---NLES---------- -----PG-VWWL-V----------------------------------------------VAESDIS----- ------------------------------------------------------------------------ ----RQLEGV--------------------L----------------------------------------- ---------REGSQVVLAV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------RKST--------------------- -------------------SLYELLVAKV-------------------------------------DTDGRP RFVIGAYW-DW------------------------------------------------------------- ---------------------------------------------ELDTA-SPEKHH--------------- ---------------------------NTAIHQP-----L------APDL-LQV----YRD----------- ----------MGGRR-LVVATKQ------------------------------------------------- ---------NM-------------------------------------------------P--------FVG -----------------------------------------LK-----E----------------------- ------------DQ-D-------------G--------------------------HLVAKSGID-V----- ------------GIMGALSQ-Q----------------------L----N----------F----------- ------------T----FQVLT-PPD---------GQ-WGG------------------------------- -----------------------------PLPDG---------------S---V------------------ SG------------------------IIG---QV--------------SR-R--------------E---AH LAIC-----------------------------------------------------------EITIT---- -GSR---ETV--V-----------DF-T-SP-----YYLEA---TTM-------------V-SPA------- --------------------------------PAL-TS--RTF-------------AIFSP---FT------ ----------------------------------YQV--W-LCI-AAA-------TL-A---VG-----PVA FIL--------------------------------------------------------------------- ---------------------AAL-MDG-------------------------------------------- ---------------------------------------Y-----------------VSPP----------- ------------------------------------------------------------------------ ----------------------------------P------------------------------------- -----------------------------SRR-APHE-----YSFQ---LFR--------NLV-----VQS- --------N-LIK-PSELPHRILFIS------WIL-----FCFYVCALYSG-----TL-----TA-VLAAPS Y--EP-----------------------TVD-----SLQDLPRAVSQ-------------------GYTL-- -----------GMIKD---------TSMMF----------------LF----K------------------- -------------E----------------------------------AK-DG--------IYREV------ -WQLFD--------HSPASQ-------------------------------------SFFRDPFS--G---- FDMIL----------Q-R-------R-L-V-MFFPSLNGELQA----IY--------------RGRHR---- -----YYFAPHH-FYP-QA-------------------------------------------------YGMA CFRG-A-P-------------------------FQPKFSQM-----------LRWMTEGGLVLH-------- ---W---------------KREVM-------------DE-------------E---SISTPSTFQGHTE--- -------------------ERWSRSTAINLKHCQAAFFLLL-------------LGLAA-GGV----ALVVE VI---------------------------------LA-TY-------S-TSRHGFFTQDTAI---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------RENKGKCSS-------------TSIYVFRC--------------------------- ----------------------------YT------------------------------------------ ---------------------------------------------------SIFLMFSSCFFSLFF------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------SVISF-------------------------------- >Csap_1534181/1-440 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------MGGRL-LRAVVVE------------------------------------------------- ---------NS-------------------------------------------------P--------YFR -----------------------------------------IK-----K----------------------- ------------TP-D-------------G--------------------------TLFPGDGID-V----- ------------NLLNILAN-K----------------------L----N----------F----------- ------------T----YQLVE-AED---------GQ-WGE------------------------------- -----------------------------VLPSG---------------W---V------------------ TG------------------------MIG---VV--------------AR-R--------------E---AD MAIN-----------------------------------------------------------EITVT---- -GKR---ERV--V-----------DF-S-TP-----YFVEG---TIL-------------V-SPA------- --------------------------------PKE-KN--RAF-------------AAFSP---FS------ ----------------------------------AQV--W-GTI-VLV-------TL-V---MG-----PVV GVV--------------------------------------------------------------------- ---------------------GWL-RQR-------------------------------------------- ---------------------------------------S-----------------IGTS----------- ------------------------------------------------------------------------ ----------------------------------GL------------------------------------ -----------------------------PTL-SLNT-----LSFT---AFR--------SLV-----VQG- --------N-LLS-PNYIPMRIVFIF------WYL-----FCFIIYAMYAG-----TL-----TA-VLALPA F--TK-----------------------PIE-----TLTDLLEAARR------------------GDLFP-- -----------AVVEG---------TSNAF----------------LF----K------------------- -------------D----------------------------------AE-GG--------IYKDI------ -WEVF-----------DPAT-------------------------------------GYAKNYDG--G---- VDKVM----------N-G-------P-F-V-FVNARLGSEVRA----AA--------------RGVQK---- -----FYISRES-FYP-QS-------------------------------------------------YAVA FPTG-S-P-------------------------IRVVINPI-----------LTSITASGVIGK-------- ---W---------------MKAEV-------------LK-------------V---TKSVEEEKN------- -------------------------YAITLVHLQAAFFILL-------------LGFLL-ASA----AFVTE KI---------------------------------YY-R--------------------------------- --------------------CAHYGLAMGMD---------------G------------------------- --------------------------------PALSFLQHNNIRGSGS------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------FAPR---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap_1680865/1-707 ------------------------------------------------------MIL--------------- P----------------------------------------------------QWDLHFVHLFIISACFVSH C-------------------SSSSCLAC------------------------LPF---------------PL NMR-------------------------------------------------------------------DA H---------FPW--------------------------------------GF------------------- -----------------IASLLAAGV-------ATADLGG-------------------------------- -------------------------------------------RQSAPTLATLQ------------------ --------------------------------------------------------------------AAWR APLHLRHLS------------------QSGNQSTDVEV-----------------T---------------- ----------------------LLS--------WLLAQA--TSPL----------DLY-------------- --------------------------------------VVYD-DAH-------------------------- --------------------QGVLQEVVL--QG----EGAWAP------------------------WTLLS Y---------------------------KGL-----------HHLQQALA-TLPSLPTT------------- ------QAVVV-------LCS--EHHTR-------------------------------------------- -----------------------QVF-----------SFV------------SRN---RLER---------- -----AN-LWWL-G----------------------------------------------VAELDAA----- ------------------------------------------------------------------------ ----HRLQPL--------------------L----------------------------------------- ---------REGTHVTLAV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------PETE--------------------- -------------------FDHWLLVTRV-------------------------------------GADNVA RLVPAGRL-------------HLSG----------------------------------------------- ---------------------------------------------NVTRF-RPTKL---------------- ---------------------------------------I------VPDM-LQQ----YRD----------- ----------FGGRE-LVVATLD------------------------------------------------- ---------NW-------------------------------------------------P--------YFV -----------------------------------------IK-----T----------------------- ------------LQ-D-------------G--------------------------RRVADSGID-A----- ------------QILSTLAN-H----------------------L----N----------F----------- ------------T----HRVLS-PLD---------NQ-WGG------------------------------- -----------------------------VHPNG---------------T---V------------------ TG------------------------LIG---LV--------------AR-R--------------E---AH IAIC-----------------------------------------------------------EITIT---- -RSR---ETV--L-----------DF-T-NP-----YFLEY---VTL-------------V-SRA------- --------------------------------PAL-KN--RTF-------------AVFSP---FS------ ----------------------------------LQV--W-LCV-ALI-------TV-L---MG-----PVA SVM--------------------------------------------------------------------- ---------------------GRV-TAS-------------------------------------------- ---------------------------------------Y-----------------ERDP----------- ------------------------------------------------------------------------ ----------------------------------QQ------------------------------------ ----------------------------CTTS-STRD-----YSFS---VFR--------NLV-----VQG- --------N-LIP-VVHLPSRCVFLF------WYL-----FCFYVYALYSG-----TL-----TA-VLAVPT Y--EK-----------------------PID-----GLNDLPEAISQ-------------------GFTL-- -----------GVLTD---------SSLQY----------------IF----K------------------- -------------E----------------------------------AE-GG--------IYKKV------ -WGLFD--------HEDLSR-------------------------------------SFLKHPDL--G---- FQKVT----------Q-E-------K-F-V-FVNPQLNSELRA----SQ--------------RGYNN---- -----FHIARQA-FFP-QA-------------------------------------------------YGIA CVSG-A-P-------------------------FLAKFNQI-----------LGRVVEAGLVHH-------- ---W---------------KQQAV-------------VL-------------A---AAAAPHN--------- ------------------FDTKRRPSAISLRHLQ---MLLA-------------SCVWK-QLL----TLLTH YT---------------------------------R------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------PTPYRRGRNPRLSE-------------VYGSVHR---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelCG11155/1-910 ------------------------------------------------------MVR------KKREIVIKE NIQ------------------------------------------GRS-----YLKKICCSYIIL------- ----------------SILV---------------------------------------------ISNALPP VIRVG------------------------------------------------------------------- -------------------------AIFTEDERE-------------------------------------- ---------------SSIESAFKYAI-----------YRINKEKTL------------------LPNTQL-- --VYDIEYVPRDDSFRT--TKKVCS-QL--------EAGVQAIF---------------------------- ---------------------------------------------------------------------GPT -DAL--------------------LASHVQSICEAYDI-----------------PHI--EGR--------I DLEYNSKEFSINL---YPSHTLLTL--------AYRDI---MVY-LN------WTKV--------------- -----------------------------A--------IIYE-EDYG------------------------- ------------------------LFNLM--HSSTETKAEM-----------------------YIRQA--- --------------------------SPDSY-----------RQVLRAIRQKEIYK---------------- --------IIV-------DTN--PSHIK-------------------------------------------- -----------------------SFF-----------RSI------------LQL---QMND---------- ----HRY--HYMFT----------------------------------------------TFDLETY----- -DLEDFRYNSV------NITAFRLVD------------------------VDSKRYLEVINQMQ-------- ----KLQHNGLDT------INGS-----PYI----------------------------------------- -----------QTESALMF----D--------------------------------SVYAF-A--------- ----NGLHFLNLDNHQ---------------------------------------NFYIKNLSCT------- ------SDQT-WNDGISLYNQ---------------------------INAAITD----------------- -------GLTGTVQFVE-GR---------------------------------------------------- ------------------RNIFKLDILKLKQ--------------------------------EK------- -IQKVGYW--------------------------------------------------HPDD---------- ---------------------------------------------GVNIS-DPTAFYDS------------- ----------------------------NIAN---------------------------------------- -------------IT-LVVMTRE------------------------------------------------- ---------------------------------------------------------E-RP--------YVM ------------------------------------------------------------------------ -------VKEDKNL-T-------------GNLRF---------------------------EGFC-I----- ------------DLLKAIAT-Q----------------------V----G----------F----------- ------------Q----YKIEL-VPD---------NM-YGVYI----------------------------- -----------------------------------------PETN----S---W------------------ NG------------------------IVQ---EL--------------ME-R--------------R---AD LAVA-----------------------------------------------------------SMTIN---- -YAR---ESV--I-----------DF-T-KP-----FMNLG---IGI-------------LFKVP------- --------------------------------TSQ-PT--RLFS-------------FMNP---LA------ ----------------------------------IEI--W-LYV-LAA-------YI-L---VS-----FAL FVMARF------------------------------------------------------------------ --------------------SPYE-WKN-------------------------------------------- -----P------------------------------HPCY-----------------KETD----------- ------------------------------------------------------------------------ ----------------------------------IVEN-QF------------------------------- ---------------------------------SISN-----SFWF---ITG--------TFL-----RQG- ---------SGLN-PKATSTRIVGGC------WFF-----FCLIIISSYTA-----NL-----AA-FLTVER M--IS-----------------------PIE-----SASDLAEQT----------------------EIS-- -----------YGTLE---------GGSTM---------------TFF----R------------------- -------------DSKIG-------------------------------------------IYQKM------ -WRYMENR---KTAV-------------------------------------------FVKTYED--G---- IKRVME-----------G-------S-Y-A-FLMESTMLDY--------------------AVQRDCN---- -----LTQIGGL-LDS-KG-------------------------------------------------YGIA TPKG-S-P-------------------------WRDKISLA-----------ILELQEKGIIQI-------- ---L---------------YDKWW-------------KN-------------TGDV--CNRDDKSKES---- -----------------------KANALGVENIGGVFVVLL-------------CGLAL-AVV----VAIFE FC---------------------------------WN----------------------------------- --------------------SRKN---LNTEN---------------------------------------- -----------------------------------QSLCSEMAEELRFAMHC---------------HGSKS RHRPRKRSC--------------------------------------------------------------- -----------------------------------------------------LNCSSVPT----------- ----------YVPSNV-------------------------------------------------------- ------------------------------------------------------STSNVGV----------- ------------------------------------------------------------------------ -------------------------------------YYNYFN----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelClumsy/1-1002 ------------------------------------------------------------------------ ---------------------------------------------------------MYSLFLTHFLL---- --------------------------------------------------IALP----------VLADIDRS QFMVG------------------------------------------------------------------- -------------------------SIFTSDKD--------------------------------------- ----------------ESEIAFRTAV-----------DRANI----------------------LE-RNVEL --VPIVVYANTDDSFIM--EKMVCNLIS--------Q-GVIAIF---------------------------- ---------------------------------------------------------------------GPS TGS---------------------SSDIIASICDTLDI-----------------PHIVYDWIPNESIP--- --DREHSTMTLNV---HPDNLLLSQ--------GLAEI---VQS-FA------WRSF--------------- -----------------------------T--------VVYE-TDKE------------------------- ------------------------LQQLQ--DILQVGEPISNPT--------------------TVKQL--- ------------------------GP-GDDH-----------RPFLKEIKLSTDNC---------------- --------LIL-------HCA--PDNLL-------------------------------------------- -----------------------KIL-----------QQA------------NEL---KMLG---------- ----EYQ--SVFIP----------------------------------------------LLDTHSI----- -----------------DFGEL-------------SGVEAN---------ITTVRL--MDPSDFHVKNVVHD WEEREKREGRYFKVD-------------PNRVKS-------------------------------------- -----------QM--ILLN----D--------------------------------AVWLF-S--------- ----KGLTELG-----------------------------------------IFEELTAPDLECR------- -------RKKPWPFGKRIIEF---------------------------IKARSEE----------------- --T-----STGRIDFNENGQ---------------------------------------------------- ------------------RSFFTLRFMELNSDGF-------------------------------------- --LDLATW--------------------------------------------------DPVNG-LD------ ---------------------------------------------VLNDD---------------------- -------------------------EESEKRVGQ------------------------KLS----------- ----------N--KT-FIVSSRL------------------------------------------------- ---------------------------------------------------------G-AP--------FLT -----------------------------------------LR-----EPQEGE--------IL-------- ---------------T-------------GN---------------------------SRYEGYS-I----- ------------DLINEIAK-M----------------------L----N----------F----------- ------------K----FEFRM-SPD---------GK-YGA------------------------------- -----------------------------LNKVT--------------QT---W------------------ DG------------------------IVR---QL--------------ID-G--------------N---AD LGIC-----------------------------------------------------------DLTMT---- -SSR---RQA--V-----------DF-T-PP-----FMTLG---ISI-------------LFSKP------- --------------------------------PTP-PT--DLFS-------------FLSP---FS------ ----------------------------------LDV--W-IYM-GSA-------YL-F---IS-----LLL FALARM------------------------------------------------------------------ --------------------APDD-WEN-------------------------------------------- -----P------------------------------HPC------------------KEPE----------- ------------------------------------------------------------------------ ----------------------------------EVEN-IW------------------------------- ---------------------------------SIMN-----TTWL---SIG--------SLM-----GQG- --------CDIL--PKAASTRLVTGM------WWF-----FALMMLNSYTA-----NL-----AA-FLTNSR Q--AN-----------------------SIN-----SAEDLAAQS----------------------KIK-- -----------YGAMA---------GGSTM---------------GFF----R------------------- -------------DSNFS-------------------------------------------TYQKM------ -WTAMESA---SPSV-------------------------------------------FTKTNDE--G---- VERVQKGK---------N-------L-Y-A-FLMESTTLEY--------------------NVERKCD---- -----LVQIGGW-LDY-KS-------------------------------------------------YGIA MPFN-S-P-------------------------YRKQISAA-----------VLKLGELGQLAE-------- ---L---------------KRKWW-------------KE-------------MHGGGNCEKSDEDGGD---- ------------------------TPELGLENVGGVFLVLG-------------LGLLS-AMV----LGCTE FL---------------------------------WNVKS-------V-AIEEK------------------ -----------------------------------------------------------------------I SLKEA----FKSEALFAARIWI--TTKP-------VHTSSESGSSNSSSS-------------------SSS RSKHSFKSQ--------------------------------------------------------------- -----------------------------------------------------GLSMKSLKSS--------- --------GYQDVEASVHSK---------------------------------------------------- --------------------------------------LKKIGSMFSLK---SQKTVTPPPE-IGW------ ------------------------------------------------KLDKSTQIDVVPTSDVDQ------ --------------------------------ELIPEVEPHLPHRHHHHHH--------------------H RHHHHHHQ--------------------------------PDQEHDRNP----------------------- -----------S----------------------PPE----------------------------------- >DmelGlu-R1/1-991 ------------------------------------------------------MHS--------------- -------------------------------------------------------RLKFLAYLHFICAS--- ----------------SIFWPEFSSAQQQQ-----------------------------------QTVSLTE KIPLG------------------------------------------------------------------- -------------------------AIFEQGTD--------------------------------------- ----------------DVQSAFKYAM--LNHN--------------------------------LNVSSRRF ELQAYVDVINTADAFKL--SRLICNQFS--------R-GVYSMLGAVS------------------------ --------------------------------------------------------------------PD-- ------------------------SFDTLHSYSNTFQM-----------------PFVTPWFP-----EKVL APSSGLLDFAISM---RPDYH---Q--------AIIDT---IQY-YG------WQSI--------------- -----------------------------I--------YLYD-SHDG------------------------- ------------------------LLRLQ--QIYQELKPGNE----------------------TFRVQMVK RIA--------------------NVTMAIEF-----------LHTLEDLGRFSKKR---------------- --------IVL-------DCP--AEMAK-------------------------------------------- -----------------------EII----------VQHV------------RDI---KLGR---------- ----RTY--HYLLS----------------------------------------------GLVMDNHW---- -PSDVVEFGAI------NITGFRIVD-------SNRRAVRDFHDSRKR----------LEPSGQ-------- ----SQSQNAGGPNSL------------PAI----------------------------------------- -----------SAQAALMY----D--------------------------AVFV--LVEAF-N--------- ----RILRKKPDQFRSNHLQRRSH-------GGSSSSS-------------ATGTNESSALLDCN------- --TS-KGWVTPWEQGEKISRV---------------------------LRKVE------------------- -----IDGLSGEIRFDEDGR---------------------------------------------------- ------------------RINYTLHVVEM---------------------------------------SVNS TLQQVAEW--------------------------------------------------RDDA---GL----- --------------------------------------------LPLH---SHNYASSS------------- ---------------------------RSASAST------------------------GDY----------- ----------DRNHT-YIVSSLL------------------------------------------------- ---------------------------------------------------------E-EP--------YLS ------------------------------------------------------------------------ ----LKQYTYGESL-V-------------GN---------------------------DRFEGYC-K----- ------------DLADMLAA-Q----------------------L----G----------I----------- ------------K----YEIRL-VQD---------GN-YGAEN----------------------------- -----------------------------QYAPG---------------G---W------------------ DG------------------------MVG---EL--------------IR-K--------------E---AD IAIS-----------------------------------------------------------AMTIT---- -AER---ERV--I-----------DF-S-KP-----FMTLG---ISI-------------M-IKK------- --------------------------------PVK-QT-PGVFS-------------FLNP---LS------ ----------------------------------QEI--W-ISV-ILS-------YV-G---VS-----FVL YFVTRF------------------------------------------------------------------ --------------------PPYE-WRI-------------------------------------------- -----V------------------------------RRPQ-----------------ADSTAQQPPGI---- ----------------------------IG------------------------------------------ -----------G----ATLSEPQA--HV----PPVPPN-EF------------------------------- ---------------------------------TMLN-----SFWY---SLA--------AFM-----QQG- --------CDIT--PPSIAGRIAAAV------WWF-----FTIILISSYTA-----NL-----AA-FLTVER M--VA-----------------------PIK-----TPEDLTMQT----------------------DVN-- -----------YGTLL---------YGSTW---------------EFF----R------------------- -------------RSQIG-------------------------------------------LHNKM------ -WEYMNAN---QHHS--------------------------------------------VHTYDE--G---- IRRVRQSK---------G-------K-Y-A-LLVESPKNEY-V------------------NARPPCD---- -----TMKVGRN-IDT-KG-------------------------------------------------FGVA TPIG-S-P-------------------------LRKRLNEA-----------VLTLKENGELLR-------- ---I---------------RNKWW-------------FD-------------K---TECNLDQETST----- ------------------------PNELSLSNVAGIYYILI-------------GGLLL-AVI----VAIME FF---------------------------------CRNKT-------P-QLKSPGSN--------------- -------------------------------------------GSAGG------------VPGMLA-----S STYQR------------------------------DSLSDAIMHSQAKLA---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------MQASSEY---DERLVGVE------------ ---------------------------------------------------LASNVRYQYSM---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelGluRIIA/1-907 ------------------------------------------------------MR---------------- -----------------------------------------------L-----CPVVIYAFIIIIGFL---- --------------------------------------------------EGII----------ALGGDDRN EITVG------------------------------------------------------------------- -------------------------AIFYENEK--------------------------------------- ----------------EIELSFDQAF-----------REVNN----------------------MKFSELRF --VTIKRYMPTNDSFLL--QQITCELIS--------N-GVAAIF---------------------------- ---------------------------------------------------------------------GPS SKA---------------------ASDIVAQIANATGI-----------------PHIEYDLKLEATRQ--- --EQLNHQMSINV---APSLSVLSR--------AYFEI---IKSNYE------WRTF--------------- -----------------------------T--------LIYE-TPEG------------------------- ------------------------LARLQ--DLMNIQALNSDYV--------------------KLRNL--- ------------------------ADYADDY-----------RILWKE----TDETFHE------------- ------QRIIL-------DCE--PKTLK-------------------------------------------- -----------------------ELL-----------KVS------------IDF---KLQG---------- ----PFR--NWFLT----------------------------------------------HLDTHNS----- -----------------GLRDIY-----------NEDFKAN---------ITSVRLKVVDANPF-------- ----ERKKTRLTKVD-------------QILGNQ-------------------------------------- -----------TMLPILIY----D--------------------------------AVVLFAS--------- ----SARNVIA-----------------------------------------AMQPFHPPNRHCG------- -------SSSPWMLGAFIVNE---------------------------MKTISED----------------- --DVEPHFKTENMKLDEYGQ---------------------------------------------------- ------------------RIHFNLEIYKPTVNE--------------------------------------- ---PMMVW--------------------------------------------------TPDNG-IKK----- --------------------------------------------RLLNLE---------------------- -------------------------LESAG-TTQ------------------------DFS----------- ----------EQRKV-YTVVTHY------------------------------------------------- ---------------------------------------------------------E-EP--------YFM -----------------------------------------MK-----EDHEN----------F-------- ---------------R-------------GR---------------------------EKYEGYA-V----- ------------DLISKLSE-L----------------------M----E----------F----------- ------------D----YEFMIVNGN---------GK-Y--------------------------------- ------------------------------NPET--------------KQ---W------------------ DG------------------------IIR---KL--------------ID-H--------------H---AQ IGVC-----------------------------------------------------------DLTIT---- -QMR---RSV--V-----------DF-T-VP-----FMQLG---ISI-------------LHYKS------- --------------------------------PPE-PK--NQFA-------------FLEP---FA------ ----------------------------------VEV--W-IYM-IFA-------QL-I---MT-----LAF VFIARL------------------------------------------------------------------ --------------------SYRE-WLP-------------------------------------------- -----P------------------------------NPAI-----------------QDPD----------- ------------------------------------------------------------------------ ----------------------------------ELEN-IW------------------------------- ---------------------------------NVNN-----STWL---MVG--------SIM-----QQG- --------CDIL--PRGPHMRILTGM------WWF-----FALMMLSTYTA-----NL-----AA-FLTSNK W--QS-----------------------SIK-----SLQDLIEQD----------------------KVH-- -----------FGSMR---------GGSTS---------------LFF----S------------------- -------------ESNDT-------------------------------------------DYQRA------ -WNQMKDF---NPSA-------------------------------------------FTSTNKE--G---- VARVRKEK---------G-------G-Y-A-FLMETTSLTY--------------------NIERNCD---- -----LTQIGEQ-IGE-KH-------------------------------------------------YGLA VPLG-S-D-------------------------YRTNLSVS-----------ILQLSERGELQK-------- ---M---------------KNKWW-------------KN-------------HN--VTCDSYHEVDGD---- --------------------------ELSIIELGGVFLVLA-------------GGVLI-GVI----LGIFE FL---------------------------------WNVQN-------V-AVEER------------------ -----------------------------------------------------------------------V TPWQA----FKAELIFALKFWV--RKKP-------MRISSSSDKSSSRRS-------------------SGS RRSSKEKSR--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------SKTVS-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelIR21a/1-842 ------------------------------------------------------------------------ ---------------------------------------------------------MSYYWVALVLFTAQA F----------------------------------------------------------------------- ----------------------------------------------------------------------SI EG---------------------------------------------------------------------- -----------DRSASYQEKCISRRLIN----------HYQLNKEIFGV-------------GMCD------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------GNNENEFRQKRRIV----------------PTFQGNPRPRG------ --ELLASKF-HVNSYNFEQTNSLVG--------LVNKIAQ-------------------------------- ---------------------EYLNKCPPV--------IYYD-SFVEKS----------------------- -------------------DGLILENLFK--TIPITFYHGEINADYEA------------------------ --------------------------KNKRF--------------------TSHIDCNC------------- ------KSYIL------FLSD--PLMTR-------------------------------------------- -----------------------KIL----------GPQT------------ESRV--VLVSR-S------- --------TQWRLR---------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------DFLSSE--------LS---------------------------- ---------SNIVNLLVIG----------------------------------------------------- ----ESLMAD-------------------------------------------------------------- --------PM--RERPYV------------------------------------------------------ ------------------------------------------------------------------------ -----------------------LYTHKLYA-----------------------------------DGLGSN TPVVLTSW---------------------------------------------------------------- ------------------------------------------IKGALSRP---------------------- --------HIN----------------------------L------FPSK-------FQFG----------- ----------FAGHR-FQISAAN------------------------------------------------- ---------------------------------------------------------Q-PP--------FIF --------------------------------------RIR------------------------------- -------------TLD-------------S-----------------------SGMGQLRWDGVE-F----- ------------RLLTMISK-R----------------------L----N----------F----------- ------------S----IDITETPTR---------SNTRGV----V-------------------------- --------------------------------DT-------------------------------------- --------------------------IQE---QI--------------IE-R--------------T---VD IGMS-----------------------------------------------------------GIYIT---- -QER--LMDS--------------AM-S-VG-----HSPDC---AAFIT-----------LASKA------- -------------------------------LPK--------YR------------AIMGP---FQ------ ----------------------------------WPV--W-VAL-ICVY------LG-GIFPIVFTDRLTLS HLMGNW------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------G--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------EVEN-----MFWY---VFG--------MFTN-AFSFTG- --------KYSWSNTRKNSTRLLIGA------YWL-----FTIIITSCYTG-----SI-----IA-FVTLPA F--PD-----------------------TVD-----SVLDLLGLFFR------------------VGTLN-- -------------------------NGGWE---------------TWF----Q------------------- -------------N----------------------------------ST-HI--------PTSRL------ ----------------YKKM-------------------------------------EFVGSVDE--G---- IGNVTQSF----FW-----------N-Y-A-FLGSKAQLEYLVQSNFSD-----------ENISRRSA---- -----LHLSEEC-FAL------------------------------------------FQ--------IGFL FPRE-S-V-------------------------YKIKIDSM-----------ILLAQQSGLIAKINNEVS-- ---WVM-------------QRSS--------------------------------SGRLLQA-SSSNSLRE- --------------------IIQEERQLTTADTEGMFLLMA-------------LGYFL-GAT----ALVSE IV---------------------------------GGITN-------------------------------- -------------------KCRQI-IKRSRKS---------------------------------------- -------------------------------AASSWSSASSGSMLRTNAEQ-----------------LSHD KRKANRR---------------------------------------------E-----------AAEVAQKM SFGMREL------------------------------------------------NLTRATLRE-IYGS--- ---------YGAPETDHGQLDIVH-----------------------------------------------T EFPNS--------------------------------SAKLNNIEDE-----ESREALESL----------- --------------------------------------------------------QRLDEFMD-------- ------------------------------------------------------------------------ ------------------------------------QMDNDGNPSSHTFRIDN------------------- ------------------------------------------------------------------------ >DmelIR25a/1-947 -------------------------------------------------------------------MILMN PKT------------------------------------------SKI-----LWLLGFLSLLSSFS----- ----------------LEIAAQTT-----------------------------------------------Q NINV-------------------------------------------------------------------- -------------------------LFINEVDN--------------------------------------- ---------------EPAAKAVEVVL-----------TYLKKNIRY----------------G-LSVQL--- --DSIEA-NK-SDAKVL--LEAICNKYATSIEKK--Q-TPHLIL---------------------------- ---------------------------------------------------------------------DTT KSGI--------------------ASETVKSFTQALGL-----------------PTISASYGQQGDLRQWR DLDEAKQKYLLQV---MPPADIIPE--------AIRSI---VIH-MN------ITNA--------------- -----------------------------A--------ILYD-DSFV------------------------- ---------------------------MD--HKYKSLLQNI-----------------------QTRHVITA IA----------------------KDGKRER-----------EEQIEKLRNLDINN---------------- --------FFI-------LGT--LQSIR-------------------------------------------- -----------------------MVL-----------ESV------------K-P---AYFE---------- ----RNF--AWHAI----------------------------------------------TQN--------- ----------------------------------EGEISSQ---------RDNATIMFMKPMAY-------- ----TQYRDRLGLLRTTYNLNEE-----PQL----------------------------------------- -------------SSAFYF----D--------------------------LALR--SFLTI-K--------- ----EMLQSGA-------------------------------------------WPKDMEYLNCD------- -DFQ-GGNTPQRN--LDLRDY---------------------------FTKIT------------------- -----EPTSYGTFDLVTQST------------------------QPFNGHSFMK------------------ -------------------FEMDINVLQIRG-------------------------------------GSSV NSKSIGKW--------------------------------------------------ISGLN--SE----- --------------------------------------------LIV------------------------- ----------------------------KDEEQM------------------------KNL----------- ----------TADTV-YRIFTVV------------------------------------------------- ---------------------------------------------------------Q-AP--------FIM ------------------------------------------------------------------------ -----------RDE-T-------------AP---------------------------KGYKGYC-I----- ------------DLINEIAA-I----------------------V----H----------F----------- ------------D----YTIQE-VED---------GK-FGN------------------------------- -----------------------------MDENG---------------Q---W------------------ NG------------------------IVK---KL--------------MD-K--------------Q---AD IGLG-----------------------------------------------------------SMSVM---- -AER---EIV--I-----------DF-T-VPY----YDLVG---ITI-------------M-MQR------- --------------------------------PSS-PS--SLFK-------------FLTV---LE------ ----------------------------------TNV--W-LCI-LAA-------YF-F---TS-----FLM WIFDRW------------------------------------------------------------------ --------------------SPYS-YQN-------------------------------------------- -----N------------------------------REKY-----------------KDD------------ ------------------------------------------------------------------------ ----------------------------------EEKR-EF------------------------------- ---------------------------------NLKE-----CLWF---CMT--------SLT-----PQG- --------GGEA--PKNLSGRLVAAT------WWL-----FGFIIIASYTA-----NL-----AA-FLTVSR L--DT-----------------------PVE-----SLDDLAKQY----------------------KIL-- -----------YAPLN---------GSSAM---------------TYF----E------------------- -------------RMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPV-SD--------KYTKM------ -WQAMQEA---KL----------------------------------------------PATLDE--A---- VARVRNSTAA-----T---------G-F-A-FLGDATDIRY--------------------LQLTNCD---- -----LQVVGEE-FSR-KP-------------------------------------------------YAIA VQQG-S-H-------------------------LKDQFNNA-----------ILTLLNKRQLEK-------- ---L---------------KEKWW-------------KN-------------DEALAKCDKPEDQ------- ------------------------SDGISIQNIGGVFIVIF-------------VGIGM-ACI----TLVFE YW---------------------------------WY-RY-------R-KNP-------------------- ------------------------------------------------------------------------ ------------------------------------RIID-VAEANA------------------------E RSNAADHPG--------------------------------------------------------------- -----------------------------------------------------KLVDGVILGHS-GEK---- ----------FEKSK--------------------------------------------------------- ----------------------------------------------AAL---RPRFNQY------------- ---------------------------------------------------PAT-FKPRF------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelIR31a/1-629 ------------------------------------------------------MNLLIS------------ -----------------------------------------------------MFILI-------------- ------------------------------------------------------------------------ ---LAAG----------------------------------------------------------------- ------------------------------------------------------------------------ --EGE-----------IIPSMEES-VVT-----------------------------------NFVK----- ------SLVKTKQAIVF------------------------------------------------------- ------------------------------------------------------------------------ ----------------------SCLFKDFKEISLALMRIN-------------------------------- --------------------------------QFVSVVN--LNQSYS------LTSILTR------------ ------------------------------------------------------------------------ --------------------ENYARTSV-----------------------------------------MVN A--------------------------------------------------------RCSGS---------- ------SE-LL------------FE-AS--------------------EN---------------------- -----------------------RYF----------NK---------------T------------------ --------YQWFLWGVD------------------------------------------------------- ------------------------------------------------------------------------ -LEVQSLFP--------------------L--NL-------------------------------------- ---NYVG--PN-AQITYVN----------------------------------------------------- ------------------------------------------------------------------------ ---E--------------------------------------------TA---------------------- -------------------------------------------------DG--------------------- ---------------------YA--YWDIHSKGRHLK----SNLEINLI-----ATLINDTLNIARD----I FH---------------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------L-QSI--DFRGQ----------- ----------FNGLT-LR-GAS-------------------------------------------------- -----------------V---------------------------------------I-DKEDIISNEQI-- ---------------------------------------ESIL----------------------------- -----------SRPTK--------------------------------------DAGVAAFIKYH-Y----- ------------ELLGLLRE-R----------------------F----N----------F----------- ------------T----VNFRN------------SRG-WAGRL----------------------------- ------------------------------GNTT---------------F---R------------------ LG------------------------LLG---IV--------------MR-N--------------E---AD IAAS-----------------------------------------------------------GAFNR---- -INR---FAE--F-----------DT-IHQS-----WKFE----TAF-------------L-YRY------- --------------------------------TSDLDTHGKSG-------------NFLSP---FS------ ----------------------------------DRV--WLFCL-LTL-------GA-F---SI-----IWV LFEII------------------------------------------------------------------- ---------------------DYKILRIRVNSQKLEH----------------------------------- LNQKSSVI---------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------CIKT----------------------------------- ---------------------------------TCIE-----RILQ---TFG--------ACC-----QQGL D--------PNPV-DR--SVRFLVMT------LFL-----FSLVMYNYYTS-----SV-----VGGLLSSSD ---Q------------------------GPS-----TVDEITASPLK------------------------- -----------ISFE----------DIGYYK--------------VLF----R------------------- -------------E----------------------------------SQ-NR--------SITRL------ -IEK-KLS---SSR-SLNEL-----------------------------P--------IFSHIED--A---- VPYLK----------A-G-------G-F-A-FHCEVVDAYPVISEYFDA--------------NEICDLRE- -----VSGLM--EVEI----------------------------------------------------LNWI LHKN-S-Q-------------------------YTEIFKT-----------AMCNAQEKGFVER-------I LRRRQI-------------------------------KKP-----------------ACQS----------- --------------------LYTV-YPVSLSGVLPGFVILI-------------CKSIN-KFS--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelIR40a/1-765 ------------------------------------------------------------------------ -----------------------------------------------------MHKFLALGLL--------- ----------------------------------------------------------------------PY L----------------------------------------------------------------------- ------------L----------------------------------------------------------- --------------------------------------------------------------GLL------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------NSTRLTFIG-------------------------------- -----------------NDESDTAIA----LTQIVRGLQQ-------------------------------- ------------------------SSLAIL--------ALPS-LALSDGV---------------------- -------------------CQKERNVYLD--DFLQRLHRS------------------------NYKSVVFS ------------------------------------------------------------------------ ----QTELFFQ------HIEENLQGANE-------------------------------------------- ---------------------CISLI------LDEPNQ---------LLNSLHDR---HLGHR--------- -------LSLFIFY----------------------------------WGA--------------------- ------------------------------------------------------------------------ ------------------------R-WPPSSRVI--------RF---------------------------- ---------REPLRVVVVT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------RPRKKAF-------------------- ----------------------RIYYNQ-------------------------------------ARPCSDS QLQLVNWY---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------DGDNLGLQRIP-----L------LPTA-LSV----YAN----------- ----------FKGRT-FRVPVFH------------------------------------------------- ---------------------------------------------------------S-PPW------FWVT -----------------------------------YCN---------------------------------- ---------------NSFEEDE-----------------------------EFNSLDSIEKRKVR-V----- ------TGGRDHRLLMLLSK-H----------------------M----N----------F----------- ------------R----FKYIE-APGRT----------QGSMRS---------------------------- --------------------------EDGKDSND---------------S---F------------------ TG------------------------GIG---LL--------------QSGQ--------------Q---AD FFLG-----------------------------------------------------------DVGLS---- -WER---RKA--I-----------EF-S--------FFTLADS-GAF-------------A-THA------- --------------------------------PRR-LN--EAL-------------AIMRP---FK------ ----------------------------------QDI--W-PHL-ILT-------II-F---SG-----PIF YGIIALPYI---WRR--------------------------------------------------------- --------------------------RWANSDVEHLG----------------------------------- -----ELYI---------------------------HMTYLKEITPRLLKLKPR-TVLSAHQM--------- ------------------------------------------------------------------------ -----------------------------------PHQ---------------------------------- ---------------------------------LFQK-----CIWF---TLR--------LFL-----KQS- --------C-NEL-HNGYRAKFLTIV------YWIA----ATYVLADVYSA-----QL-----TS-QFARPA R--EP-----------------------PIN-----TLQRLQAAMIH-------------------DGYR-- -----------LYVEK---------ESSSL---------------EML----E------------------- ------------------------------------------------NG-TE--------LFRQL------ -YALMRQQVINDPQ------------------------------------------GFFIDSVEA--G---- IKLIA----------E-G------GEDK-A-VLGGRETLFFNVQQYGSNN---------------------- -----FQLSQ--KLYTRYS--------------------------------------------------AVA VQIG-C-P-------------------------FLGSLNNV-----------LMQLFESGILDK-------- -----------------MTAAEYAKQY-------QEVEATRI------------YKGSVQAKNSE------- ------------AYSRTESYDSTVISPLNLRMLQGAFIALG-------------VG-SL-AAA----ALNNT I----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------NVRSLNSRDKFI-CGGPV------------------ ------------------------------------------------------------------------ -------------------------------------KIW------------YYLVLLL-----------WY YF---------------------------------------------------------------------- ----------------------------------------------------NRGLVGIYQLWHKTSIRN-- -----------------------------------------------TG--KGMPFLGE------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelIR41a/1-648 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------MFIDL------------------------------- ------------------SWSLVLSA---IVGKYLNES-T-------------------------------- ------------------------------------ICIFWN-DKFEFQL--LHKSD--------------- ----------------------------------------------------------------YISFVGIN IKSFDDNGG---------HYIIDTGLKKKELQNKHLFLDELVIKIIISIE-----VTHC------------- ------ETFVV-----------FDKDID-------------------------------------------- -----------------------RFVNA--------FNKASV----------YSIW--RSLH---------- --------NKFVFA----------------H-----------------------------IANESPE----- ------------------------------------------------------------------------ -------------------------SRNHF-------------F---------------------------- ---------EDQPNILFVV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------RDHSSASS--------------------- ---------------------FDIKTNKFVG----------------------------------RKAENPS QMILVDRY-------------------------------------------------LASEQRFQF------ GK---------------------------------------------------------------------- -------------------------------------S-L------FADK--------LNN----------- ----------LQGRE-VIIAGFD------------------------------------------------- ---------------------------------------------------------Y-PP--------YTV IKHN-------------------------------------MS----------------------------- -----------TNAQD------------MGVSGESD-------------------FKNVYIDGTE-T----- ------------RIVLNFCE-Q----------------------F----N----C----------------- ------------T----IQIDSSAAND-----------WGK------------------------------- -----------------------------VYPNM---------------S--------G------------- DG------------------------ALG---ML--------------IN-R--------------K---AD ICIG-----------------------------------------------------------AMYSW---- -YED---YTY--L-----------DL-S-MY-----LVRSG---ITC-------------L-VPA------- --------------------------------PLRLTS----------------WYLPLEP---FK------ ----------------------------------ETL--W-AAI-LLC-------LC-A---EA-----TGL VLA--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------YKSEQALYVL-------------PGYREGWWT-------- ---------------------------------CTSF-----GVCT---TFK--------LFI-----SQSG ----------NSK-AYSLTVRVLLFA------CFL-----NDLIITSIYGG-----GL-----AS-ILTIPS M--DE-----------------------AAD-----TVTRLRFH-----------------------RLQ-- -----------WAANSE----------------------------AWVSAI--------------------- -------------R----------------------------------AS-DEA-------LVKDI----LY NFHIYSDDE----------------------------------------------LLRLAQDQHMRIG--FT VERLP-------F----G-------H-F-A---------------------------IGNYLGPQAID---- Q----LVIMKDDIYFQ----------------------------------------------------YTVA FVPR-LWP-------------------------LLDKLNTL-----------IYSWHSSGFDKY-------- ---WEY-----------RVVADNL--------N----LK---------------IQQQVQETMTGTKDI--- -------G----------------PVPLGMSNFAGFIIVWI-------------LGSAI-ATL----TFLLE LSLT----------------------------------YI-------LKQSN-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------LK------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelIR60a/1-716 -----------------------------------------------------------------------M WCNNPG----------------------------------------------------LIIIIFLGQILNLC Q----------------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------------GI------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------VNLSNE-----TANTVIFMLPEKDLG---------PDVWKAGVG-------- ------------------------------CLDSFAQIFFFRNPKER------FTRAY-------------- ------------------------------------NLMLVHAFHL-------------------------- -------------------SSPA-----D--QIQEGFSKLIN-EAVTN--PGPPDRE-----------ELFQ ---------------------------------------------MRVASDYN------------------- ---------IT------------NGTED-------------------------------------------- ---------------------KGELI------------LA-----DNYVIVVDSVD--RLKELMKKKIV--E MRSWNPG-ARFLVLFHN-------------------------------------------ATCRNRPLGVA- ------------------------------------------------------------------------ ------------------------SNIFKDLMEM-------------------------------------- ---------FYVHRVALLY-------------------------------------------A--------- ----------------------------------------N------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------STMNYNLLVND-YYSN---------------------------------VNCRIL NVQSVGQC---------------------------------------------------------------- -----------------------------------------------------------------------H DG-----------------------------------K-L-------------------------------- ----------YPNNA-VVKASMQ------------------------------------------------- ---------DY------VS--------------------------------------GFSPR----NCTFFA ------------------------------------------------------------------------ ----------------------------CSSI-------------------SAPFVEADCILGLE-M----- ------------RILGFMKN-R----------------------L----K----------F----------- ------------D----VNQTCSLES------------RGE------------------------------- -----------------------------MDGPA---------------N---W------------------ TG------------------------LLG---KV--------------QN-N--------------E---CD F---------------------------------------------------------------VFGG-YY- -PDN-------EVAD---------HFWG-SDT----YLQDA---HTW------------YIKMAD------- --------------------------------RRP------AWQ------------ALVGI---FE------ ----------------------------------AYT--W-IGF-ILI-------LI-I---S------WLF WFTLVM------------------------------------------------------------------ -----------------------------------------------------------IL----------- ------------------------------------------------------------P----------- ------------------------------------------------------------------------ --------------------------------EPKYYQ---------------------------------- ---------------------------------QLSL-----TAIN---ALA--------VTI--SIAVQE- ------R-------PICETTRLFFMA------LTL-----YGLNVVATYTS-----KM-----IA-TFQDPG Y--LH-----------------------QLD-----ELTEVVAAGIP------------------------- ------------------------FGGHEESR-------------DWF----E------------------- ---------------------------------------------------ND--------D--DMWI---- -FNGYNISP------------------------------------------------EFIPQSKN------- LEAVK----------W-GQ------R---C-ILSNRMYT-------------------------MQSPLADV -----IYAFPNNVFSS----------------------------------P-----------------VQMI MKAG-F-P-------------------------FLFEMNSI-----------IRLMRDVGIFQKI------- ---DAD-------FRYNNTYLNRI-------------N-----------------------KMRPQFPETA- -------------------------IVLTTEHLKGPFFILV-------------VGSCW-AAL----TFIGE LI------------------------------IHRWRTQLVSTSE-QQDRRSD------------------- ------------------------------------------------------------------------ ----------------------------------KRRRRRRRRKPEKDNR---------------------- ------------------------------------------------------------------------ ----------------------------W------------------------------------------- -----QRQVQVAP----------------------------------------------------------- ----------------------------------------------------VVRFTPVK------------ ---------------------------------------------------RRKVFQGQTSQK--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelIR64a/1-861 ------------------------------------------------------MHWWLL------------ -----------------------------------------------------VFLPLSCQGLPEHELLELE LDY--------------------------------------------------------------------- ------GL---------------------------------------------------------------- ---------------------A-----EPQRT---------------------------------------- ------------------SLLQSS-LIL-----------------------------------QFS------ ------QDYKHIPRITY----FTCQK--------------PHLQT--------------------------- ------------------------------------------------------------------------ --------------------------------PNQIPN--AA------------------------------ ------------------------EH-----RDAFAAKNFQLIKSLY------ESELFVRIV---------- --------------------------------------LL-D-VLAQSPTSGRPNRPG------------NG PTGGFSQTPSQAQ-----SNSEWLEGVLR--------------------------------MEALRQIAVVD L--------------------------------------------------------ACGAV---------- ------SRRFL------------EL-AS--------------------AK---------------------- -----------------------MLY----------SE---------------K------------------ --------FHWLLIEDF--------------------------------------AWH--GRTQTAE----- ------GSGKRDDGEM-E----------------EEEPPGQQIQA-----TDDE------------------ --DLPSIES--------------------FLGGM-------------------------------------- ----NLY--MN-TELTLAK----------------------------------------------------- ------------------------------------------------------------------------ ---R--------------------------------------------M----------------------- ------------------------------------------------SEA--------------------- --------AH-----------YT--LFDVWNPGLNYG----GHV---------------------------- NLTEIGSF--------------------------------------------------TPTEGI-------- ------------------------------------------------------------------------ ------------------------QLHTWFRTTS------------------TV--RRRMD----------- ----------MQHAR-VRCMVV-------------------------------------------------- -----------------V---------------------------------------T-NKN---MTGTLM- ---------------------------------------YYL------------------------------ ------------THTM--------------------------------------SGHIDTMNRFN-F----- ------------NLLMAVRD-M----------------------F----N----------W----------- ------------T----FVLSR------------TTS-WG-------------------------------- -----------------------------YVKNG---------------R---F------------------ DG------------------------MIG---AL--------------IR-N--------------E---TD IGGA-----------------------------------------------------------PIFYW---- -LER---HKW--I-----------DV-AGRS-----WSSR----PCF-------------I-FRH------- --------------------------------PRSTQKDRI---------------VFLQP---FT------ ----------------------------------NDV--W-ILI-VGC-------GV-L---TV-----FIL WFLTTIEWKL------------------------------------------------VP-HD--------- --------GSAL-----IKPKGGAPPRHHYQQQQQQEQVEAP----------------------------VR PITAVSVVVSKEKVEEKQEEYED-----------------------------------STPIDAGTLWQR-- ---------CYQKLNK-------------------------------------------------------- -----------------YIKD----RKAKQKKAPERVG---------------------------------- ---------------------------------LFLE-----SVLF---FVG--------IIC-----QQG- ---------LGFS-TSFVSGRCIVIT------SLL-----FSFCIYQFYSA-----SI-----VGTLLMEKP ---K------------------------TIK-----TLSDLVHSSLK------------------------- -----------VGME----------DILYNR--------------DYF----L------------------- -------------H----------------------------------TK-DP--------VSMEL------ -YAK-KITS-V-PTTKENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPET--G---- LLRVK----------H-E-------R-F-A-FHVDVAAAYKIIAETFSE--------------QDICDLTE- -----VSMFP---PQK----------------------------------------------------TVSI MQKN-S-P-------------------------MRKVISY-----------GLRRVTETGILTY-------H FNVWHS-------------------------------RKP-----------------PCVKK---------- --------------------IETSDLHVDMDTVSSALLILL-------------FSYAI-TLM----ILGTE IL---------------------------------Y-SK--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------WHNRI-- ------------------------------------------------------------------------ ------------------------------------------------------QLK--------------- -------------------------------------------------WVGAT------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelIR68a/1-704 ------------------------------------------------------------------------ ------------------------------------------------------MRCLWILIVAFISLAMAT S----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------IPIPIAN- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------PAPLSGY---------------------------------- ----------------EMQLKILLQK-------ILWV-AN-------------------------------- -----------------------VKRC-FA--------VITD-DLHY------------------------- --------------------PIYDRIFFE--SVGRR----------------------------VIPFFVM- -----------------------RTNESDDLQRPSR----QVELFVKAIK-----SSDC------------- ------ELNVI------TILN--GWQVQ-------------------------------------------- -----------------------RFL-----------GYI------------YDN---RSLN---------- -----MQ-KKFVLL------------------------------------------HDLRLFESDMI----- ----------------------------------------------------------------------H- ------------------------------L------------W---------------------------- ---------SVFIDAIFLK----------------------------------------------------- --------------------------------R--------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------QLDN--------------------- --------------------KYTISTIAF-----------------------------------PGILSGVL VMKNIANW---------------------------------------------------------------- ------------------------------------------------------------------------ --------E-----------------LGKGLNGR---I-L------FADK--------TSN----------- ----------LFGTS-LPVAISE------------------------------------------------- ---------------------------------------------------------H-VP----------- ---------------------------------------MVLW----------------------------- --------------ANAT----------KS------------------------------FQGVE-V----- ------------EIMNALGK-A----------------------L----N----------F----------- ------------K----PVYYK-PNQT---EN---MD-WTE------------------------------- -----------------------------LDGGA---------------S---VAYGSGNPDGYAQNGTHID SM------------------------LVD---EV--------------AA-H--------------S---AR FAIG-----------------------------------------------------------DLHLF---- -QVY---LKL--V-----------EL-S-AP-----HNFEC---LTF-------------L----------- -------------------------------TPES-ST-DNSWQ------------TFILP---FS------ ----------------------------------AGM--W-VGV-LLS-------LF-V---VG-----TVF YAISFL------------------------------------------------------------------ ---------------------NAIINGNV------------------------------------------- SSEFFRCL-------RPNRNV-------PMDPKIYRRISF---------RIAI------SRYRSSKG----- ------------------------------------------------------------------------ --------------------------------------------------------DRMP------------ -----------RDLFD-----------------GYTN-----CILL---TYS--------MLL-----YVA- --------L-PRM-PRNWPLRVLTGW------YWI-----YCILLVATYRA-----SF-----TA-ILANPA A--RV-----------------------TID-----TLEDLLRSHIP-PS---------------------- -------------------------TGATE-------------NRQFF----L------------------- -------------E----------------------------------AN-DE--------VARKV------ ----------------GEKM-------------------------------------EVFGYSDD--L---- TSRIA----------K-G-------Q-C-A-YYDNEFYLRYLRV------------------ADESGS---- ----ALHIMKEC-VLY-MP-------------------------------------------------VVLA MEKN-S-A-------------------------LKPRVDAS-----------IQHLAEGGLIAK-------- ---W---------------LKDAI-------------EHL-------------------------------- ----------------PAEALAQQEALMNIQKFWSSFVALL-------------IGYVI-SML----TLLAE RW---------------------------------HF----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----KHIVMKHPMYDVYNPSLYY-----------NFKRIYPQH---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelIR75a/1-629 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------MQLVQL----ANFVLDNLVQ-------------------------------- ------------------------SRIGFI--------VLFH-----C------------------------ ---------------------------WQSDESLKFAQQFM----------------------KPIHPILV- ------------------------------------------------------------------------ --------YHQ------FVQ---------------------------------------------------- ---------------------MRGV--------------------LNW-SHLELS---YMGHT--------- ----QPTLAIYV------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------DIKCD--------QT---------------------------- ---------QDLLEEASRE----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------QIYNQHY-------------------- --------------------HWLLVGNQ-------------------------------------SKLEFYD LFGLFNIS---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------IDADVSYVKEQ-----IQDNNDSVAYAVHDV----YNNGKIIGGQLNVT GSHEMSCDPFVCRRT-RHLSSLQ------------------------------------------------- ---------------------------------------------------------K-RS----------K -----------------------------------YGNREQLT----------------------------- ------------D------------------------------------------------VVLR-VATVVT QRP---LTLSDDELIRFLSQ-ENDTHIDSLARFGFHLTLILRDLL----H----------C----------- ------------K----MKFIF-------------------------------------------------- --------------------------SDSWSKSD---------------V---V------------------ GG------------------------SVG---AV--------------VD-Q--------------T---AD LTAT-----------------------------------------------------------PSLAT---- -EGR---LKY--L-----------SA-I--------IETGFFR-SVC-------------I-FRT------- --------------------------------PH---N--AGLRGD----------VFLQP---FS------ ----------------------------------PLV--W-Y-L-FGG-------VLSL---IG------VL LWITFYMEC--------------------------------------------------------------- ---------------------KRMQKRWR------------------------------------------- -------------------------------------LDYL------------------------------- ------------------------------------------------------------------------ -----------------------------------PS----------------------------------- ----------------------------------LLS-----TFLI---SFG--------AAC-----IQS- --------S-SLI-PRSAGGRLIYFA------LFLI----SFIMYNYYTSV-----VV-----SS-LLSSPV K--SK------------------------IK-----TMRQLAESSLT-------------------VGLE-- -----------PLPFT---------KSYLN---------------YSR----L------------------- ------------------------------------------------PE-IH--------LFIKR------ -KIESQTQN-----------------------------------------------PELWLPAEQ--G---- VLRVR----------D-N------PG-Y-V-YVFETSSGYAYVERY-------------------------- -----FTAQEICDLNEVLFRPEQL--------------------------------------------FYTH LHRN-S-T-------------------------YKELFRLR-----------FLRILETGVYRK-------- -----------------QR--SYW------------------------------------------------ ------------VHMKLHCVAQNFVITVGMEYVAPLLLMLI-------------CADIL-VVV----ILLVE L---------------------------------------------------A------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------W- ------------------------------------------------------------------------ -----------------------------------------------------KRFFTRHLTFHP------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelIR75d/1-675 ------------------------------------------------------MKVQVA------------ -----------------------------------------------------HWLPLIFFLLVS------- -----------------------------------------------------------------------G TPRVAGSW---------------------------------------------------------------- ---------------------RS--EYSRQDPDPKTR----------------------------------- ----------------WGNQLPDM-LVA-----------------------------------YYR------ ------H--HGVHSLML----VVCHTDIAD----------FRLWK--------------------------- ------------------------------------------------------------------------ ----------------------------LWQHFNLNNFYVQV------------------------------ ------------------STE---SS-----LRDLQHVD-ALDEHKD------APPPK-------------- -----------------------------------------S-FHANNSTHWETSFL--------------- -------LPALP----------YKMGIL-----------------------------------------LLE FSS------------------------------------------------------ECALN---------- ------LL-RW------------SA-AS--------------------EH---------------------- -----------------------NYF----------TT---------------N------------------ --------RFWLLLTEDPGD---------------------------------------------------- ------------------------------------------------------------------------ ---ID------------------------LLEDP-------------------------------------- ----EIFIPPD-SELRVLH----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------YENV--------------------- --------GN-----------FSCSLIDLYKVAAWKP----LKR---------------------------- --TLVG----------------------------------------------------HN------------ ------------------------------------------IRNSRHVI---------------------- -------------------------HAL-QHFGS------------------AI--TYRQD----------- ----------LEGIV-FNSAIV-------------------------------------------------- -----------------I---------------------------------------A-FP-------DLF- ---------------------------------------TNI------------------------------ ------------EDLS--------------------------------------LRHIDTISKVN-H----- ------------RLMLELAN-R----------------------L----N----------M----------- ------------S----YNTYQ------------TVN-YGWRQ----------------------------- -------------------------------PNG---------------S---F------------------ DG------------------------LMG---RF--------------QR-Y--------------E---LD LAQL-----------------------------------------------------------AIFMR---- -LDR---IAL--V-----------DF-VAET-----YRVR----AGI-------------M-FRQ------- --------------------------------PPLSAV-AN---------------IFAMP---FE------ ----------------------------------NDV--W-VSI-LML-------LI-I---TT-----VVL ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------VL---------------ELFFSPHNH-------- ------------------------------------------------------------------------ -----------------------------------DMS---------------------------------- ----------------------------------YMD-----TLNF---VWG--------AMC-----QQG- ---------FYVE-VRNRSARIIVFT------TFV-----AALFLFTSFSA-----NI-----VA-LLQSPS ---D------------------------AIQ-----SLSDLGQSPLE------------------------- -----------IGVQ----------DTQYNK--------------IYF----T------------------- -------------E----------------------------------ST-DP--------VTKNL------ -YHK-KIA----SKGE-----------------------------------------NIYMRPLL--G---- MEKMR----------T-G-------L-F-A-YQVELQAGYQIVSDTFSE--------------PEKCGLME- -----LEPFQ---LPM----------------------------------------------------LAIP TRKN-F-P-------------------------YKELIRR-----------QLRWQREVSLVNR-------E ERKWIP-------------------------------QKP-----------------KCEG----------- --------------------GVGGFVSIGITECRYALGIFG-------------CGAAV-SFV----LFLFE FI---------------------------------F-RHF-------K-QVYR------------------- ------------------------------------------------------------------------ -------------------------------------II-K------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------GYREVQR ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelIR76a/1-646 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------MENLLVESY------------------------------- ------------------YFSTVLSF---FAQQFFADSHA-------------------------------- ------------------------------------TCIFWH-PAFDFRLETVHP----------------- -----------------------------------------------------------------MPLIIMD WHRWANRSD---------QDVYDYKIKEDEFEGKGIPYNDWTLRLTVAIE-----RSHC------------- ------ETFIA-----------FQEQIP-------------------------------------------- -----------------------EFARY--------FYHASI----------YSIW--RSLR---------- --------NRFMFV----------------Y------------------------------TKEFED----- ------------------------------------------------------------------------ -------------------------KKDSYLSGY--------IF---------------------------- ---------QDQPNILVIT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------SQYLNSST--------------------- ---------------------FEIKTNRFVGPR------------------------------NFNKNPEPV EFYILQRF-------------------------------------------------DAKGTKATWE----- TQ---------------------------------------------------------------------- -------------------------------------S-A------MSSK--------MRN----------- ----------LKGRE-VVIGIFD------------------------------------------------- ---------------------------------------------------------Y-KP--------FML LDYEK--------------------PP--------LYYDRFMN----------------------------- -----------TT--------------------------------------------DVTIDGTD-I----- ------------QLMLIFCE-L----------------------Y----N----C----------------- ------------T----IQVDTSEPYD-----------WGD------------------------------- -----------------------------IYLNA---------------S--------G------------- YG------------------------LVG---MI--------------LD-R--------------R---ND YGVG-----------------------------------------------------------GMYLW---- -YEA---YEY--M-----------DM-T-HF-----LGRSG---VTC-------------L-VPA------- --------------------------------PNRLIS----------------WTLLLRP---FQ------ ----------------------------------FVL--W-MCV-MLC-------LL-L---ES-----LAL GIT--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------RRWEHS-SVA-------------AG--NSWIS-------- ---------------------------------SLRF-----GCIS---TLK--------LFV-----NQST ----------NYV-TSSYALRTVLVA------SYM-----IDIILTTVYSG-----GL-----AA-ILTLPT L--EE-----------------------AAD-----SRQRLFDH-----------------------KLI-- -----------WTGTSQ----------------------------AWITTIDE------------------- -------------R----------------------------------SA-DPV-------LL-GL----ME HYRVYDANL----------------------------------------------ISAFSHTEQM--G--FV VERLQ-------F----G-------H-L-G---------------------------NTELIENDALK---- R----LKLMVDDIYFA----------------------------------------------------FTVA FVPR-LWP-------------------------HLNAYNDF-----------ILAWHSSGFDKF-------- ---WEW-----------KIAAEYM--------N----AH---------------RQNRIVASEKTNLDI--- -------G----------------PVKLGIDNFIGLILLWC-------------FGMIC-SLL----TFLGE L--------------------------------------W-------RGQG--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelIR76b/1-636 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------MATGIE--LLV--------AAALC----------------VACP-PLND SPPTNLIQM----------------GENGT------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------L----------------------------------------- ---------SPVTELPM------DVDASEAGFDAD------------------------------------- ------------------------------------------------------------------------ -------APVE------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------TLET-------------------------------------INRKKP KLREMLDW---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------IGGKH-LRIATLE------------------------------------------------- ---------------------------------------------------------D-FP--------LSY -----------------------------------------TE----------------------------- -----------VLE-N-------------GTR---------------------------VGHGVS-F----- ------------QIIDFLKK-K----------------------F----N----------F----------- ------------T----YEVVV-PQD---------NI-IGSP------------------------------ -----------------------------SDFDR-------------------------------------- -S------------------------LIE---MV--------------NS-S--------------T---VD LAAA-----------------------------------------------------------FIPSL---- -SDQ---RSF--V-----------YY-STTT-----LDEGE---WIM-------------V-MQR------- --------------------------------PRE-SA--SGS-------------GLLAP---FE------ ----------------------------------FWV--W-ILI-LVS-------LL-A---VG-----PII YALIIL------------------------------------------------------------------ --------------------RNRL-T---------------------------------------------- -----------------------------------------------------------GD----------- ------------------------------------------------------------------------ ----------------------------------GQQT-PY------------------------------- ---------------------------------SLGH-----CAWF---VYG--------ALM-----KQG- --------S-TLS-PIADSTRLLFAT------WWI-----FITILTSFYTA-----NL-----TA-FLTLSK F--TL-----------------------PYN-----TVNDILT-----------------------KNKH-- -----------FVSMR---------GGGVE---------------YAI------------------------ -------------R----------------------------------TT-NE--------SLSML------ -NRMIQNN---YAV--------------------------------------------FSDETND--T---- YNLQN-------YVEK-N-------G-Y-V-FVRDRPAINIMLYRDYLYRK-----TVSFSDEKVHCP---- -----FAMAKEP-FLK-KK-------------------------------------------------RTFA YPIG-S-N-------------------------LSQLFDPE-----------LLHLVESGIVKH-------- ---L---------------SKRNL-------------PS-------------A---EICPQDLGG------- -----------------------TERQLRNGDLMMTYYIML-------------AGFAT-ALA----VFSTE LM---------------------------------F--RY-------V-N---------------------- --------------------SR-------------------------------------------------- ------------------------------------QEANKWARH-----GIGR-------------TPNGQ SVAPSRWLR-------------------GWRRLNS--------------GHGQLLG---------------- -----------------------------------------------------ASTHGQN------------ --------VTPPPPYQSIFNGGSH-------------GDPLNRWR--------------------------- ------------RPLANGNAL-------GNGVLLGG---DSEGGVRRLI---NGRDYM-------------- ------------------------------------------------------VFRNPNG-QSQLV----- ------------------------------------------------------------------------ ----------------------------------------PVRSPS-------------------------- ------------------------------------AALFQYSYTE-------------------------- >DmelIR84a/1-644 ------------------------------------------------------------------------ ------------------------------------------------------MIKLQVKVIS-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------W----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------PLI-------------- ---------------------------------ILTAFLR-------------------------------- --------------------------------------VLQI-ESINTNF---------------------- ------------------LELAAFEDFLR--------------------------------SEHLSHVLVVR GDDADGDWKIECH-----------------------------QKLLANYRVQFYRPEMSANFEDLM------ FYGSPRTAVLVLN----------SEHVL-------------------------------------------- --------------------VRRQVFGV--------ASEA---------GYFNNS----------------- --------LAWFILG---------------------------------------------SGRESLP----- --------------------------------------------------------------------V--- ------------------------EQLIDQLLSGY-------RM---------------------------- ---------GIDADITVAL----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------RGPDNASMLFYDVYR--------------------------------ISRQANTPL IIEKKGLW--------------------------------------------------THSGGYQKFG---- ------------------------------------------------------------------------ -------------------------------------N--------------------FKNTWV-------- ----------IRRRNFLNVTLIG------------------------------------------------- ---------------STVLT-------------------------------------EKPP--GFGDMEYLA -------------------------------------DDKQLQ----------------------------- ----------QLDPMQRKT-----------------------------------------------Y----- ------------QLFQLVER------------------------M--F-N----------L----------- ------------S----LAISL------------TDK-WGE------------------------------- -----------------------------LLDNG---------------S---W------------------ SG------------------------VMG---QV-------------TSR----------------E---AD FAVC-----------------------------------------------------------PIRFV---- -LDR---QPY--V-----------QY-S-AV-----LHTQN---IHF-------------L-FRH------- --------------------------------PRR-----SHIKN-----------IFFEP---LS------ ----------------------------------NQV--W-WCV-LAL----------V---TGST---ILL LFHVRLER---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------MLS------------------------------ ---------------------------------NMEN-RFS-FVWF---TML-------ETYL-----QQG- --------PANEI-FRLFSTRLLISL------SCI-----FSFMLMQFYGA-----FI-----VGSLLSESA R---------------------------SIV-----NLQALYDSNLA------------------------- -----------IGMENI------------------------SYNFPIF----T------------------- -------------N----------------------------------TS-NQ--------LVRDV------ YVKKICKSG-----------------------------------------------EHNIMSLQQ--G---- AERII----------Q-G-------R-F-A-FHTAIDRMYRLLLELQMDE-------------AEFCDLQEV -------------MFN-LP---------------------------------------YD--------SGSV MPKG-S-P-------------------------WREHLAHA-----------LLHFRATGLLQY-------N DKKW------------------------------------------------MVRRPDCSL----------- --------------------FKTSQAEVDLEHFAPALFALA-------------LAMVA-SAL----VFLLE LFLHWLPD---------------------------FRRRL-------------------------------- ------------------------------------------------------------------------ -----------------------------------GTMST-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelIR8a/1-936 ------------------------------------------------------------------------ ---------------------------------------------------------MELPLL-V------- ----------------LLLALRFAGSEVLKITFWI-----------------EP----------VQRAEFD- -TDIA------------------------------------------------------------------- -------------------------MVLKELDA--------------------------------------- ----------------LRLD--------------------------------------------VKVD---- --DTTLTLTRSEDGL-D--MQRFCEILS--------TVGASAVI---------------------------- ---------------------------------------------------------------------DLT YSH----------------------WEEGYNLVRSLGI-----------------GYVRLERI--------- -------------------MRPFLD--------MFGDF---MRQ-KR------ANNV--------------- -----------------------------A--------MVFM-NARD------------------------- ---------------------------AV--EAMQQMLVGY-----------------------PFRTLIMD ASQ---------------------TDPGQHF-----------LERIRSLRPAP-TY---------------- --------IAL-------FAR--AAAMN-------------------------------------------- -----------------------GIF-----------EKV------------QKA---DLFQ---------- ----RPL--EWHFV----------------------------------------------FLDTRD------ ---RVFKYRR--------------QAELCTRFTLNPRAICRSM-PMPDLYCGSG------------------ ------------------------------F----------------------------------------- -----------TMQRAMLL----N--------------------------------VLRSL-I--------- ----NAAQVS-------------------------------------------PGYPLAIYQDCN------- -ATA------SSSEVSDPLEK---------------------------D---D------------------- -YNWLDMVHWSNFLA------------------------------YAPPLPHIQDQFQ-------------- ------------SPVPGLTFAVNISA-------GYY------SSEHEAK-------------------TDLA AWSSVGEM--------------------------------------------------R------------- ------------------------------------------------------------------------ ------------------------------LLNE------------------------TIS----------- ----------PARRF-FRIGTAE------------------------------------------------- ---------------------------------------------------------S-IP--------WSY ------------------------------------------L-----RREEG------------------- ------TGELIRDR-S-------------GL---------------------------PIWEGYC-I----- ------------DFIIRLSQ-K----------------------L----N----------F----------- ------------E----FEIVA-PEV---------GH-MGE------------------------------- -----------------------------LNELG---------------E---W------------------ DG------------------------VVG---DL--------------VR-G--------------E---TD FAIA-----------------------------------------------------------ALKMY---- -SER---EEV--I-----------DF-L-PPY----YEQTG---ISI-------------A-IRK------- --------------------------------PVR-RT--SLFK-------------FMTV---LR------ ----------------------------------LEV--W-LSI-VAA-------LV-G---TA-----IMI WFMDKY------------------------------------------------------------------ --------------------SPYS-SRN-------------------------------------------- -----N------------------------------RQAY-----------------P-------------- ------------------------------------------------------------------------ ----------------------------------YACR-EF------------------------------- ---------------------------------TLRE-----SFWF---ALT--------SFT-----PQG- --------GGEA--PKAISGRMLVAA------YWL-----FVVLMLATFTA-----NL-----AA-FLTVER M--QT-----------------------PVQ-----SLEQLARQS----------------------RIN-- -----------YTVVK---------DSDTH---------------QYF----V------------------- -------------NMKFAEDTLYRMWKELALN---ASKDFKKFRIWDYPI-KE--------QYGHI------ -LLAINSS---QP----------------------------------------------VADAKE--G---- FANVDAHENA-----D-----------Y-A-FIHDSAEIKY--------------------EITRNCN---- -----LTEVGEV-FAE-QP-------------------------------------------------YAVA VQQG-S-H-------------------------LGDELSYA-----------ILELQKDRFFEE-------- ---L---------------KAKYW-------------NQ-------------S-NLPNCPLSED-------- ------------------------QEGITLESLGGVFIATL-------------FGLVL-AMM----TLGME VL---------------------------------YY-KK-------K-Q-NAL------------------ ------------------------------------------------------------------------ -----------------------------------EITQV---RPV-----------------------NDS SGSGGNSST--------------------------------------------------------------- -----------------------------------------------------APP---------------- ------------------------------------------------------------------------ --------------------------------------------TATST---TKQAWHIPV---LE------ ------------------------------------------------AEEKPAKVSP-------------- ------------------------------------------------------------------------ -------------------------------------------PPSFE------------------------ -------TATFR----------------------GKKLPARITLGDGKFKPRHGLYARRNLGASDSHSGYME >DmelIR92a/1-678 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------MLLQPLV------------------------------ -----------------MHLSQLLRI---IVGQYFAEFPS-------------------------------- ------------------------------------ILIVYNNSASTTPLQLEYLSA--------------- -----------------------------------------------------------------LELVLRE LSKPIRLQ------------WINVAFLKD--------LNDLEDQVMGALN-----SSVT------------- ------EGFIT-----------ILSQTH-------------------------------------------- -----------------------HFIHA--------RYYATR----------NANV--RLKD---------- --------KRYLFL----------------C-----------------------------EDESPAE----- ------------------------------------------------------------------------ -----------------------------LLCMD--------IL---------------------------- ---------QFYPHHLMVR----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------PGTETAPTGPTGPHPDPRRGGGASVSTKN KDDGEGGAGN-KTTSPYRDINFELWTQKFVG------------------------------------AVGNL DALLLDAF-------------------------------------------------LPN-ETFAN------ RV---------------------------------------------------------------------- -------------------------------------E-L------YPNK--------LLN----------- ----------LQRRS-LLVGSIT------------------------------------------------- ---------------------------------------------------------Y-VP--------YTI TNYV----------------------P--------------------------------------------- --------------AG------------QGDVDPIHPQW---------------PNRSLTFDGAE-A----- ------------NVMKTFCQ-V----------------------H----N----C----------------- ------------H----LRVEAYGADN-----------WGG------------------------------- -----------------------------IYDNE---------------S--------S------------- DG------------------------MLG---DI--------------YE-Q--------------R---VE MAIG-----------------------------------------------------------CIYNW---- -YDG-----I--T-----------ET-S-HT-----IARSS---VTI-------------L-GPA------- --------------------------------PAPLPS----------------WRTNIMP---FN------ ----------------------------------NRA--W-LVL-IST-------LV-I---CG-----TFL YFMKY------------------------------------------------------------------- -----------------------VSYRL-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------RYSGTQVKFH-------------HS------R-------- ---------------------------------KLEK-----SMLD---IFA--------LFI-----QQPS ---------APLS-FDRFAPRFFLAT------ILC-----ATITLENIYSG-----QL-----KS-MLTFPF Y--SA-----------------------PVD-----TIEKWAQS-----------------------GWK-- -----------WSAPSI----------------------------IWVHTV-Q------------------- -------------S----------------------------------SD-LET-------EQ-IL----AR NFEVHDYSY----------------------------------------------LSNVSFMPNY--G--FG IERLS-------S----G-------S-L-S---------------------------VGDYVSTEALE---- N----RIVLHDDLYFD----------------------------------------------------YTRA VSIR-GWI-------------------------LMPELNKH-----------IRTCQETGLYFH-------- ---WEL-----------EFIDKYM--------D----KK---------------KQEVLMDLANGHKVK--- -------G---------------APQALDVRNIAGALFVLA-------------FGVAF-AGC----ALVAE LLIH----------------------------------RM-------DLSK--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmelIR93a/1-848 -----------MNPG--------------------------------------EMRPS-------------- ---------------------------------------------ACL-LLL-AGLQLSILV----PTE--- ------------------------------------------------------------------ANDFSS ---FL-----------------------------------------------------------------SA N--------------------ASLAVVVD------------------------------------------- -HEYMTVH--GENILAHFEKILSDVI-------REN---LRN--------------------GGINVKYFSW --NAV-RLKK-DFLAAI--TVTDCENTWNFYKNTQET---SILLIAITD----------------------- --------------------------------------------------------------------SDCP R----------------------------LPLNRALMT-----------------VECR------------- ------------------------------------------------------INAV-------------- --------------------------------------VFVD-QTI-------------------------- -----------------------LEEN-A--LLVKSIVHESITNHIT-----------------PISLILYE INDSL----------------RGQ-QKRVAL-----------RQALSQFA-PKKHEEMR------------- ------QQFLV-------I----SAFHE-------------------------------------------- -----------------------DII-----------EIA------------ETL---NMFH---------- -----VG-NQWMIF----------------------------------------------VLDMVAR----- ------------------------------------------------------------------------ ----DFDAGTV----------------TINL----------------------------------------- ---------DEGANIAFAL----N--ETDP--NCQDSLN-----------CTISE-ISLAL-V--------- ----NAISKITVEEESIYGEISDE------------------------------------------------ -EWE-AIRFTKQEKQAEILEY---------------------------MKEFL------------------- -----------------------------------------------KTNAKCS------------------ -----------------SCARWRVETAITWGKSQENRKFRSTPQRDA--------------------KNRNF EFINIGYW-----------------------------------------------------TPVLG------ --------------------------------------------FVCQEL---------------------- ---------------------------------------A------FPHI--------EHH----------- ----------FRNIT-MDILTVH------------------------------------------------- ---------------------------------------------------------N-PP--------WQI -----------------------------------------LT----------------------------- -----------KNS-N-------------GVI--------------------------VEHKGIV-M----- ------------EIVKELSR-A----------------------L----N----------F----------- ------------S----YYLHE-------------------------------------------------- -----------------------------ASAWK---------------E---E------------------ DSLSTSAGGNESDELVGSMTFRIPYRVVE---MV--------------QG-N--------------Q---FF IAAV-----------------------------------------------------------AATVE---- -DPD---QKP--F-----------NY-T-QP-----ISVQK---YSF-------------I-TRK------- --------------------------------PDE-VS--RIY-------------LFTAP---FT------ ----------------------------------VET--W-FCL-MGI-------IL-L---TA-----PTL YAINRL------------------------------------------------------------------ --------------------APLK-E---------------------------------------------- ---------------------------------------M-------------------------------- ------------------------------------------------------------------------ ----------------------------------RIVG-LS------------------------------- ---------------------------------TVKS-----CFWY---IFG--------ALL-----QQG- --------G-MYL-PTADSGRLVVGF------WWI-----VVIVLVTTYCG-----NL-----VA-FLTFPK F--QP-----------------------GVD-----YLNQLEDHK---------------------DIVQ-- -----------YGLRN---------GTFFE---------------RYV----Q------------------- -------------S----------------------------------TT-RE--------DFKHY------ -LERAKIY---GS------------------------------------------------AQEE--D---- IEAVK----------R-G-------E-R-I-NIDWRINLQLIVQRHFER--------------EKECH---- -----FALGRES-FVD-EQ-------------------------------------------------IAMI VPAQ-S-A-------------------------YLHLVNRH-----------IKSMFRMGFIER-------- ---W---------------HQMNL-------------PS-------------A---GKCNGKSAQR-Q---- ----------------------VTNHKVNMDDMQGCFLVLL-------------LGFTL-ALL----IVCGE F----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------WYR--------------------------- ------------------------------------------------------RFRA-------------- ---------------------------------------------------SRKRRQ--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------FTN------------------------------ >DmelNmdar1/1-997 ------------------------------------------------------MA--------MAEFVFCR PLF------------------------------------------G-----------LAIVLLVA------- ----------------PIDAAQRH-----------------------------------------TASDNPS TYNIG------------------------------------------------------------------- -------------------------GVLSNSD---------------------------------------- -----------------SEEHFSTTI-----------KHLNFDQQY------------------VPRKVT-- --YYDKTIRMDKNPIKT--VFNVCDKLI--------ENRVYAVVVS-------------------------- --------------------------------------------------------------------HEQT SGDL--------------------SPAAVSYTSGFYSI-----------------PVIGISSR--------- DAAFSDKNIHVSFLRTVPPYYHQAD--------VWLEM---LSH-FA------YTKV--------------- -----------------------------I--------IIHS-SDTD------------------------- --------------------GRAILGRFQ--TTSQTYYDDV-----------------------DVRATVEL IVE--------------------FEPKLESF-----------TEHLIDMKTAQSRV---------------- --------YLM-------YAS--TEDAQ-------------------------------------------- -----------------------VIF-----------RDA------------GEY---NMTG---------- ----EGH--VWIVT----------------------------------------------EQALFS------ ------NNTPD------GVLGLQL------------------------------------------------ ----------------------------EHA----------------------------------------- -----------HSDKGHIR----D--------------------------------SVYVL-A--------- ----SAIK--EMISNE---------------------------------------TIAEAPKDCG------- ------DSAVNWESGKRLFQY---------------------------LKSRNIT----------------- -------GETGQVAFDDNGD---------------------------------------------------- ------------------RIYAGYDVINIRE--------------------------------QQKKH---- ---VVGKF--------------------------------------------------SYDSM-RAK----- --------------------------------------------MRMRIN-DSEIIWPG------------- ----------------------------KQRRKP------------------------EGI----------- ----------MIPTH-LRLLTIE------------------------------------------------- ---------------------------------------------------------E-KP--------FV- ------------------------------------------------------------------------ ---------YVRRMGD-------------DEFRC-EPDE----RPCPLFNNSDATANEFCCRGYC-I----- ------------DLLIELSK-R----------------------I----N----------F----------- ------------T----YDLAL-SPD---------GQ-FGHYIL---------------------------- -----------------------------RNNTGAM-----TLRK----E---W------------------ TG------------------------LIG---EL--------------VN-E--------------R---AD MIVA-----------------------------------------------------------PLTIN---- -PER---AEY--I-----------EF-S-KP-----FKYQG---ITI-------------L-EKK------- --------------------------------PSR-SS--TLVS-------------FLQP---FS------ ----------------------------------NTL--W-ILV-MVS-------VH-V---VA-----LVL YLLDRF------------------------------------------------------------------ --------------------SPFGRFKL-------------------------------------------- -----S------------------------------HS---------------------DS----------- ------------------------------------------------------------------------ ----------------------------------NEEK-AL------------------------------- ---------------------------------NLSS-----AVWF---AWG--------VLL-----NSG- --------IGEGT-PRSFSARVLGMV------WAG-----FAMIIVASYTA-----NL-----AA-FLVLER P--KT-----------------------KLS-----GINDARLRNT-------------------MENLT-- -----------CATVK---------GSSVD---------------MYF----R------------------- -------------RQVE---------------------------------------------LSNM------ -YRTMEAN---N-----------------------------------------------YATAEQ--A---- IQDVKK-----------G-------K-LMA-FIWDSSRLEY--------------------EASKDCE---- -----LVTAGEL-FGR-SG-------------------------------------------------YGIG LQKG-S-P-------------------------WTDAVTLA-----------ILEFHESGFMEK-------- ---L---------------DKQWI-------------FH-------------GHVQQNCELFEKT------- ------------------------PNTLGLKNMAGVFILVG-------------VGIAG-GVG----LIIIE VI---------------------------------YK-KH-------Q-VKKQKRLDIARHAADK------- --------------WRGTIEKR-------------------------------------------------- -----------------------------------KTIRASLAMQRQYNVG------------------LNS THAP----G--------------------------------------------------------------- -----------------------------------------------------TISLAVDKRRY-PRLG--- -----Q---RLGPE------------RAWP-----------------------GDAADVLRIRRPYELG--- ----------------------------------NP------GQSPKVM---AANQPGMPMPMLGK------ ------------------------------------------------TRPQQSVLPPRYS----------- ------------------------------------------------------------------------ ----------------------------------------PGYTSDVS------------------------ -------HLVV------------------------------------------------------------- >DmelNmdar2/1-1083 ------------------------------------------------------MM--------PSRVKLKR GTDGPTPTPTPMPTTMRKHTPIATLNTASCQ--HNS---TTSRRKRIL-----TPPSGPISLLLLTVL---- ----------------TLLILDTRSCQGLRLTNGGG------SLSKGAAAN-------------------KE QLNIG------------------------------------------------------------------- -------------------------LIAPHTNFGK------------------------------------- ---------------REYLRSINNAVTGLTKTRGAKLTFLKD--------------------YSFEQKN--- --IHFDMMSLTPSPTAI--LSTLCKEFL--------RVNVSAILYMMNN----------------------- --------------------------------------------------------------------EQFG HSTA--------------------SAQYFLQLAGYLGI-----------------PVISWNADNSG-----L ERRASQSTLQLQL---APSIEHQSA--------AMLSI---LER-YK------WHQF--------------- -----------------------------S--------VVTS-QIAG------------------------- ------------------------HDDFV--QAVRERVAEMQE---------------------HFKFTILN SIV------------------------VTRT-----------SDLMELV-NSEARV---------------- --------MLL-------YAT--QTEAI-------------------------------------------- -----------------------TIL-----------RAA------------EEM---KLTG---------- ----ENY--VWVVS----------------------------------------------QSVIEKK----- -D--------------------------------------------AH------------------------ ----------------------------SQF----------------------------------------- ---------P-VGMLGVHF----DTSSAA---------------------------LMNEI-S--------- ----NAIKIYSYGVEAY----------------LTDPA-------------NRDRRLTTQSLSCE------- -----DEGRGRWDNGEIFFKY---------------------------LRNVSIE----------------- -----GDLNKPNIEFTADGD---------------------------------------------------- ------------------LRSAELKIMNLRP-----------SAN-----------------------NKNL VWEEIGVW--------------------------------------------------KSWET--QK----- --------------------------------------------LDIR-----DIAWPG------------- ----------------------------NSHAPP------------------------QGV----------- ----------PEKFH-LKITFLE------------------------------------------------- ---------------------------------------------------------E-AP--------YIN -----------------------------------------LS-----PADPVSGKCLMDRGVLCRVAADHE MAADIDVGQAHRNE-----------------------------------------SFYQCCSGFC-I----- ------------DLLEKFAE-E----------------------L----G----------F----------- ------------T----YELVR-VED---------GK-WGTLE----------------------------- --------------------------------NG---------------K---W------------------ NG------------------------LIA---DL--------------VN-R--------------K---TD MVLT-----------------------------------------------------------SLMIN---- -TER---EAV--V-----------DF-S-EP-----FMETG---IAI-------------VVAKR------- -------------------------------------T--GIISPT----------AFLEP---FD------ ----------------------------------TAS--W-MLVGIVA-------IQ-A---AT-----FMI FLFEWL------------------------------------------------------------------ --------------------SPSG-YDM-------------------------------------------- -----KLY-------------------------LQNTNVT-----------------P-------------- ------------------------------------------------------------------------ -------------------------------------Y-RF------------------------------- ---------------------------------SLFR-----TYWL---VWA--------VLF------QA- --------AVHVDSPRGFTSRFMTNV------WAL-----FAVVFLAIYTA-----NL-----AA-FMITRE E--FH-----------------------EFS-----GLNDSRLVHPF-S---------------HKPSFK-- -----------FGTIP---------YSHTD---------------STI----H------------------- -------------KYFNV--------------------------MHNYM---R--------QYN-------- -----------------------------------------------------------KTSVAD--G---- VAAVLN-----------G-------N-LDS-FIYDGTVLDYLV------------------AQDEDCR---- -----LMTVGSW-YAM-TG-------------------------------------------------YGLA FSRN-S-K-------------------------YVQMFNKR-----------LLEFRANGDLER-------- ---L---------------RRYWM-------------TG-------------T-----CRPGKQEHKS---- ------------------------SDPLALEQFLSAFLLLM-------------AGILL-AAL----LLLLE HV---------------------------------YF-KY-------I-RKRLAKKD--------------- ---------------------------------------------GGH------------------------ -------------CC--------------------ALISLSMGKSLTFRG---------------------- ------------------------------------------------------------------------ ---------------------------------------------------------AVFEATE-ILKK--- -----H--RCNDPICDTHL------------------------W---------------------------- ----------------------------------------KVKHELDMS---RLRVRQLEKV-MDK------ ------------------------------------------------HGIKAPQLRL-------ASSS--- ------------------------------------------------------------------------ -----------------------DLLNHHHLKER------PPLLGNLS---------------LAASAQDLY RWSYK---TEIA----------------------EMETVL-------------------------------- >DpulIR25a/1-942 ------------------------------------------------------------------------ -------------------------------------------------------MRSFQLLLVLGL----- -----------------AFAVQSA-----------------------------------------------D PIRV-------------------------------------------------------------------- -------------------------LLVYETNN--------------------------------------- ---------------VDADRAFTAVQ-----------SYLERTKVQ----------------G-LSLGN--- --VTRVTLDS-TQKYLT--VDDVCSVYDKSIDAG--T-PPHIVL---------------------------- ---------------------------------------------------------------------DLT WSGL--------------------SSEVMKALTRNLGL-----------------PTISGSYGGIGDLKHWS NIDGNQTKYLVQV---MPPSDIIPQ--------LVALI---TSM-QN------MTNA--------------- -----------------------------A--------ILYD-DSFD------------------------- ---------------------------ML--NKYKSLLKNR-----------------------PIRHMFSK IE--------------------------TNI-----------NTQIRRLEDMDIVN---------------- --------FFV-------LGK--IDRIN-------------------------------------------- -----------------------QVL-----------MSA------------AQE---NYFG---------- ----KKY--SWTAI----------------------------------------------SKD--------- ---------------------------------GSAEPFVR---------TENGSILFAVPTVN-------- ----PDVAN--GILFKTSGLNNG-----YSV----------------------------------------- -------------DTGFYF----D--------------------------LILR--AITTV-K--------- ----NMLDGNT-------------------------------------------WPVDMSYSKC-------- -SMT-NITAVTRNN-FDLRKA---------------------------FADTN------------------- -----VGSTFANMIL------------------------------NGNGKSYPQ------------------ -------------------VEMTINQMNFKN-------------------------------------SRLE SKNALGIW--------------------------------------------------KAGMP--GE----- --------------------------------------------ISF------------------------- ----------------------------SPGQSL------------------------RPF----------- ----------QVISV-FKIAVVV------------------------------------------------- ---------------------------------------------------------Q-AP--------FIM ------------------------------------------------------------------------ ----------KRKA-N-------------GT---------------------------VTFYGYC-V----- ------------DLIKDIQA-I----------------------M----G----------F----------- ------------E----YELYE-VPD---------GK-YGN------------------------------- -----------------------------MDSKM---------------N---W------------------ NG------------------------MIK---EL--------------ME-K--------------R---AD IGLG-----------------------------------------------------------ALAVM---- -AER---ENV--I-----------DF-T-VPY----YDLVG---ISI-------------L-MAK------- --------------------------------PQV-ST--SLFK-------------FLTV---LE------ ----------------------------------NDV--W-GCI-LAA-------YF-F---TS-----ILL WIFDRW------------------------------------------------------------------ --------------------SPYS-YQN-------------------------------------------- -----N------------------------------KEKY-----------------ADDP----------- ------------------------------------------------------------------------ ---------------------------------EEEKR-EF------------------------------- ---------------------------------SLKE-----SLWF---CMT--------SLT-----PQG- --------GGES--PKHLSGRLIAAT------WWL-----FGFIIIASYTA-----NL-----AA-FLTVSR L--DS-----------------------PVN-----SLDDLSTQY----------------------KVQ-- -----------YAPQN---------GTDVA---------------TYF----E------------------- -------------RMAYIEKRFYEIWKDMSLNDSMNEVERSKLAVWDYPV-SD--------KYTKI------ -WQSMQDA---GL----------------------------------------------PHTFDE--A---- LTRVRASNAE-----NND-------G-F-A-FLGDATDIRY--------------------QVLVNCD---- -----LQMVGEE-FSR-KP-------------------------------------------------YAVA VQEG-S-P-------------------------LRDLLNDA-----------ILRLLNQRRLET-------- ---L---------------KERWW-------------TD-------------NPEKQECGDTNDQ------- ------------------------SDGISIQNIGGVFIVIF-------------VGIFL-ACV----TLAIE YC---------------------------------YF-KV-------R-RNPEG------------------ ------------------------------------------------------------------------ -----------------------------------DEVVS-TPESRNNA--------------------AGN RNKLDDAYV--------------------------------------------------------------- -----------------------------------------------------KNSQKPFVLDD-NSK---- -----------DPYAG-------------------------------------------------------- -------------DYGYYGA------------------KKELELEGDGP---RPR----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------KAW-------------------------------- >DpulIR298/1-642 ------------------------------------------------------------------------ ------------------------------------------------------MEGFIRILVLLSALQFKL C----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------TSENRLDRHKHLKV---------------------------------- ---------------------EFIH--------ELADRGR-----FQ------WKSLT-------------- -----------------------------V--------LFTK-DAID------------------------- -------------------------------------------------------DNSDWIFDVKVPKVMME LPTID------------------------------------------------------------------- ------DSFIS-------IAQ--QQPTD-------------------------------------------- ---------------------AYLIL---------------------------------------------- -------------IS--------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------EQSTEMAAIN--------------------------S----------VLKLFVS--------- ----KQLDSTK------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------TCLIFSAKSAAILNRE---------------------------------NDLDLI LVQDTVSW--------------------------------------------------NSNTGLVNKPIL-- ----KFVRHRSLS--------------------------------SMEPE-QLTGYYD-------------- GGILKA-------------------------DQK---R-I------LFDR--------SIN----------- ----------YRNRQ-VKVTTFL------------------------------------------------- ---------------------------------------------------------S-PP----------- ---------------------------------------TTI------------------------------ -----------RCK-D-------------GII------------------------NGHQMCGRD-P----- ------------NLIRVIGE-V----------------------L----H----------F----------- ------------R----PVFSS-PAQP--------GSKWGN------------------------------- -----------------------------KLDNG---------------E---W------------------ TG------------------------LIG---EV--------------SR-G--------------V---TT LGVA-----------------------------------------------------------NVFMT---- -VHY--IEQV--------------EF-S-YP-----YDMSC---STF-------------L-TPS------- --------------------------------PEL-WP--QLY-------------ALIKP---FD------ ----------------------------------LSI--W-LAT-VFS-------LV-I----G-----GLL IQLVAL------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------VY-----------HKMFG----------------SRDPLR--------- ------------------------------------------------------------------------ ---------------------------------------FFG----------E------------------- ---------------------------------AMIY-----NAQS---ITG----------------TRS- --------G-SDE-RSSWPVRVYTSN------WWL-----FCFLLGTVYRT-----GL-----IS-WLARSP IL-MA-----------------------PVD-----TIAQLVRSDLTPYG---------------------- -------------------------------------------YNTFV----R------------------- -------------DLAQY------------------------------SI-DP--------DTIQL------ -GGRLKL---------------------------------------------------VPPNMTA--Q--LL MG--Q----------E-N-------V-N-A-IFENKQYL------KYLSVMVVP-------STMGNISINSV DPRQRLHVMREC-LRS-FP-------------------------------------------------VAIA MTPG-T-P-------------------------FRSAMTQI-----------IHQLNAAGIIDH-------- ---W---------------LDSVV------------QTE-------------VAFTTKRYKKKE-------- --------------------------PFSLHSLEGVFYLLL-------------ICYSI-DVV----AFVAE LV---------------------------------YH-RV-------S-CRHFLAG---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------NDETVD--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DpulIR304/1-519 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------MI------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------ENN----------- ----------LEGQT-LRVGITE------------------------------------------------- --------SSML---------------------------------------------T-EP--------YYG ATDQ------------------------------------TVK----------------------------- ----------------------------------------------------------------V-L----- ------------KIINLLQS-Q----------------------L----N----------F----------- ------------T----YQLIT-LPK---------ASGIGI------------------------------- -----------------------------SQENG---------------S---W------------------ SG------------------------LIG---LL--------------ER-K--------------E---ID VIAER----------------------------------------------------------VLFLP---- -HFR---DAV--------------DL-S-IP-----LGQDE---WVT-------------L-QKQ------- --------------------------------PSR-LN--SLT-------------ALLSP---FE------ ----------------------------------IEV--W-LLV-ALS-------IV-G---MI-----PVM FIIYRL------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------HL-----------------KFHP----------- ------------------------------------------------------------------------ ----------------------------------QAAN-YF-----------RG------------------ ---------------------------------RLSD-----FVLF---VVV--------SLL-----KQD- --------H-KLR-ISIHSQRVLMAT------WWI-----VGLLLTTFYTA-----NL-----TA-SLARPY Q--ER-----------------------SLQ-----HPRELSWPAY--------------------KDSK-- -----------WLTLS---------EKLMP---KISS-----HNQEFI----K------------------- -------------P--------------------------------N-HT-GAT-------DFDLL------ -SQHLKSG---RGN--------------------------------------------LVSSIHA--A---- LNLTK----------R-G-------S-Y-I-WFGPYEMLLEVMLVNYRLNQ-----ANNG---THECS---- -----FLITDKS-YLT------------------------------------------VE--------YGLA FAKN-S-S-------------------------LTPIFNQA-----------IRLIDQSGILEF-------- ---S---------------RRASF-------------TG-------------K---NPCSIGNG-------- ----------------------YTSRAMQLGDFLGLFCITL-------------IGLST-ATV----TFIWE RI---------------------------------PK-YC-------K-S---------------------- --------------------WR-------------------------------------------------- ---------------------------------------KKTTNTAAVSP---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------VSAVCKPVVPNPKISNAN-------------TYQLELEI--------------------------- -------------------------------------EKLTEEIDRMLL---TDKDIRGILV---------- -----RHCPNF----------VFF--------------------------VEQVLIIVTGIADR-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DpulIR93a/1-897 -----------MLLRVLLVLASAFIHVQSAHYE-----------------LYSELRPDERWFLDDTKLIPVS ------------------------CENGDCSALFNKHNKHKIAKRAAV-QVE-TMKDYIKFLLRGNKTK--- ------------------------------------------------------------------DDDTNT DP-YR-----------------------------------------------------------------TA N--------------------ITLGVVMD------------------------------------------- -KNLIGNLQTFTNI----FDVANMPS-------NPEIDYLRL--------------------QKFNVTYLNP ---QD-KLPS-NINAVL--SILPCDVLTRFDKNLASL---PILHIAITS----------------------- --------------------------------------------------------------------DNCP R----------------------------ITRWAVLMV-----------------PVVK-TG---------- --------------------AELPQ--------IFTDLR--LSDTLN------WKEAV-------------- --------------------------------------VIAE-EHA-------------------------- -----------------------NKELFD--GLVDSLSRPVHKKD-------------------PLALTVVK L--------------------HG--PVALRK-----------KNFESQLL-NLQVRPKG------------- ------RNFIL-------VSK--QDTAL-------------------------------------------- -----------------------WAF-----------DAA------------SHV---GLVN---------- -----PY-SQWLFL----------------------------------------------ITDS-------- ------------------------------------------------------------------------ -----TDPAIF----------------LPNV----------------------------------------- ---------EDGQNISFLY----NISDIETTANANSSSER-----VNDLPCYTSN-LLQVY-V--------- ----KALHQLIREEETHYFQTTED------------------------------------------------ -DWI-RSKPSAGDRRNNIFRT---------------------------LQNMW------------------- -----------------------------------------------KDATKCS------------------ -----------------SWLNWAMKAVEI-------------------------------------KETRKP TLLDVGVW-----------------------------------------------------DAAHG------ --------------------------------------------LVVYDD---------------------- ---------------------------------------F------FPHF--------TGG----------- ----------LRQRV-INVTTME------------------------------------------------- ---------------------------------------------------------F-PP--------WQI -----------------------------------------FE----------------------------- -----------RNS-H-------------GKV--------------------------VRHTGLV-L----- ------------ELTKELGN-R----------------------L----N----------F----------- ------------S----VNVVE-PAD---------GK-WGS------------------------------- -----------------------------RLSFS---------------R---W------------------ TG------------------------MVE---QV--------------RT-G--------------S---VA FAAA-----------------------------------------------------------GFTVT---- -ADR---MSA--V-----------NF-S-MS-----LDAQP---YTF-------------M-FAR------- --------------------------------PKQ-LS--RAY-------------LFIQP---YT------ ----------------------------------PNA--W-ITI-FAM-------TI-G---AG-----PLI WAFNKI------------------------------------------------------------------ --------------------TPFY-D---------------------------------------------- ---------------------------------------F-----------------YPDR----------- ------------------------------------------------------------------------ ----------------------------------PGSP-IF------------------------------- ---------------------------------SIWY-----NIWY---CIG--------ALL-----FQG- --------Q-REM-PIALSGRMVVGF------FWL-----FVIVVLTAYSG-----NL-----VA-FLTFPT Y--TN-----------------------PIN-----TLQDLIDNK---------------------GSLT-- -----------WGILR---------GTALE---------------DYL----K------------------- -------------T----------------------------------SD-EK--------MYREL------ -YEGAILH---DTA-----------------------------------------------DDV---L---- LDMIR----------N-Q-------Q-H-V-YIEWKTNLQWLMKQDFMK--------------TNSCD---- -----FSLGTEN-FFL-QQ-------------------------------------------------VALA FPRD-S-P-------------------------ILERVNLE-----------IIYMQRGGLIEH-------- ---W---------------RQEFW-------------PS-------------A---DRCSETATGGSD---- ---------------------GDTIQAISVADMQGSFYVLF-------------F----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------GK------------------- -----------------------------------------------------TKNLGT------------- ------------------------------------------LYN--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------LFI--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------NGKFMYE----------------------------- >EFX75437.1/1-518 hypothetical protein DAPPUDRAFT_323372 [Daphnia pulex] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------MI------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------ENN----------- ----------LEGQT-LRVGITE------------------------------------------------- --------SSML---------------------------------------------T-EP--------YYG ATDQ------------------------------------TVK----------------------------- ----------------------------------------------------------------V-L----- ------------KIINLLQS-Q----------------------L----N----------F----------- ------------T----YQLIT-LPK---------ASGIGI------------------------------- -----------------------------SQENG---------------S---W------------------ SG------------------------LIG---LL--------------ER-K--------------E---ID VIAER----------------------------------------------------------VLFLP---- -HFR---DAV--------------DL-S-IP-----LGQDE---WVT-------------L-QKQ------- --------------------------------PSR-LN--SLT-------------ALLSP---FE------ ----------------------------------IEV--W-LLV-ALS-------IV-G---MI-----PVM FIIYRL------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------HL-----------------KFHP----------- ------------------------------------------------------------------------ ----------------------------------QAAN-YF-----------RG------------------ ---------------------------------RLSD-----FVLF---VVV--------SLL-----KQD- --------H-KLR-ISIHSQRVLMAT------WWI-----VGLLLTTFYTA-----NL-----TA-SLARPY Q--ER-----------------------SLQ-----HPRELSWPAY--------------------KDSK-- -----------WLTLS---------EKLMP---KISS-----HNQEFI----K------------------- -------------P--------------------------------N-HT-GAT-------DFDLL------ -SQHLKSG---RGN--------------------------------------------LVSSIHA--A---- LNLTK----------R-G---------Y-I-WFGPYEMLLEVMLVNYRLNQ-----ANNG---THECS---- -----FLITDKS-YLT------------------------------------------VE--------YGLA FAKN-S-S-------------------------LTPIFNQA-----------IRLIDQSGILEF-------- ---S---------------RRASF-------------TG-------------K---NPCSIGNG-------- ----------------------YTSRAMQLGDFLGLFCITL-------------IGLST-ATV----TFIWE RI---------------------------------PK-YC-------K-S---------------------- --------------------WR-------------------------------------------------- ---------------------------------------KKTTNTAAVSP---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------VSAVCKPVVPNPKISNAN-------------TYQLELEI--------------------------- -------------------------------------EKLTEEIDRMLL---TDKDIRGILV---------- -----RHCPNF----------VFF--------------------------VEQVLIIVTGIADR-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_11061962/1-687 ------------------------------------------------------MMP------------GCL P----------------------------------------------------SLTLLYLVCILARALCALP E-------------------PSKR----------------------------------QHLPS-----HTPV L----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------PHLPGVTL-------SLHQDYS-------------------------------- -------QHLLPSY---------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------NRSVTEVRLTT-----------------EEG-------------- ----------------------LVA--------LLTSA---TVDI----------NLY-------------- --------------------------------------LLYD-HTN-------------------------- --------------------YEVDG-LVR--SH----QEVGSG---------------------DKSVTVVK Y--------------------------SEDL-----------SPLQAVLTTTATHT-GT------------- ------RHVLV-------LCS--TKNTQ-------------------------------------------- -----------------------RIF-----------QYV------------RER---QLEL---------- -----PS-LWWL-M----------------------------------------------VGETDLS----- ------------------------------------------------------------------------ ----QTLQPL--------------------L----------------------------------------- ---------WEGSLVTLAV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------RTSS--------------------- -------------------TSYSIMISRV-------------------------------------DSTGLP KFVPVGSW---------------------------------------------------------------- ---------------------------------------------ILTPS---GPV---------------- ----------------------------VQVQEP-----L------VPDP-LKL----YSD----------- ----------MSGRQ-LIVTANN------------------------------------------------- ---------NW-------------------------------------------------P--------FFG -----------------------------------------LD-----K----------------------- ------------FR-D-------------G--------------------------KVQKKTGID-I----- ------------EIMNTLGQ-F----------------------L----N----------F----------- ------------T----YHVVS-PAD---------GQ-WGG------------------------------- -----------------------------PLPDG---------------T---V------------------ SG------------------------LIG---QV--------------AR-R--------------E---AH VAIC-----------------------------------------------------------EITVT---- -GSR---ETV--V-----------DF-T-IP-----YYLET---LIL-------------V-SRA------- --------------------------------PAE-KN--RVF-------------AVFSP---FS------ ----------------------------------VQV--W-LCI-VAS-------TV-A---IG-----PIV SLL--------------------------------------------------------------------- ---------------------GHG-LDL-------------------------------------------- ---------------------------------------Y-----------------VSWP----------- ------------------------------------------------------------------------ ----------------------------------P------------------------------------- ------------------------------RR-KLRD-----YSFN---MYR--------NMV-----TQG- --------N-LLT-TPHWPHRLVFFF------WYL-----FCFYIYALYSG-----TL-----TA-VLALPA Y--EE-----------------------PID-----SLTDLPDAVAN-------------------GFTV-- -----------GTLGD---------SNIEY----------------MF----K------------------- -------------E----------------------------------AK-EG--------IYKEV------ -WGLFN--------HKDRSK-------------------------------------SFFKTVDP--G---- FDQIT----------R-R-------K-F-V-LMNPQLNSEVRA----AQ--------------RGKDK---- -----YHLGRQP-FYP-QG-------------------------------------------------YGIA CNKG-A-P-------------------------FIPKFNQM-----------LTRISQAGLIAY-------- ---W---------------KEKEI-------------QM-------------I---SGGPPAQDS------- -------------------TTERGPSAITLKHLQAAFFVLM-------------MGFIV-AVL----ALGLE FV---------------------------------VS-KF-------L------------------------ ------------------------------------------------------------------------ --------------------------------------------TSQ------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------MGEWT---------------GTDHQW--------------------------- ----------------------------GS------------------------------------------ ---------------------------------------------------Q-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_11356156/1-855 ------------------------------------------------------MM---------------- K----------------------------------------------------RVSQHHITLTYSDGFPSLT V-------------------TEIV-----KT-----------------RRKRCSHHVIQSGVQ-----TLDQ EFG----------------------VLKEAEVCNVTGLGYHGSFIAQVNLNLGVHVL--KGLGLLPMIRIEC HMTTGVILTTLMWRNMLGVKQTNLYVLLRRIKSRYLPSPPSCVIKLIGRRNNFKKMRKLPHLLFLCLALATV RKTNAHRPRVEASVVQPRPTLTNTTT-------TAHQQY--------------------------------- --------------------------------SVRSS--RSLL------ASHDC------------------ --------------------------------------------------------------------VNCS FPLLL----------------------HIKKTDEDSVV-----------------AE--------------- ----------------------LMS--------YLITF---TSGT----------QFY-------------- --------------------------------------LVYD-DLL-------------------------- --------------------PGVGG-VLR--TC----QEAWVD------------------------TTLLP Y--------------------------RPTS-----------QLLMETLK-SFYHALPM------------- ------RNIVV-------LCS--PQHVI-------------------------------------------- -----------------------TLF-----------EEV------------KKN---MVES---------- -----PT-IQWL-V----------------------------------------------FAKEDLT----- ------------------------------------------------------------------------ ----ERLPGM--------------------L----------------------------------------- ---------REGTQVALIQ----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------RATT--------------------- -------------------RKALLFSSRV-------------------------------------DPDDQI RFHHVGVW---------------------------------------------------------------- ------------------------------------------------SA-DIGGN---------------- ----------------------------QQEE-------L------IPDL-EQM----YSD----------- ----------FQGRE-LLVTTND------------------------------------------------- ---------NW-------------------------------------------------P--------FFK -----------------------------------------IN-----T----------------------- ------------FD-N-------------G--------------------------TIIPISGID-L----- ------------QVITTLSD-S----------------------L----N----------F----------- ------------T----FRVIR-PPD---------DN-WGG------------------------------- -----------------------------PQPDG---------------S---I------------------ TG------------------------LVG---QV--------------AR-H--------------E---AH ATLC-----------------------------------------------------------ELTIT---- -SSR---ETV--V-----------DF-T-AP-----YYMES---TTL-------------V-SNA------- --------------------------------LKE-KN--RAF-------------AVFSP---FT------ ----------------------------------AQV--W-ICI-CVV-------TA-L---VG-----PVL YVV--------------------------------------------------------------------- ---------------------SHI-MIV-------------------------------------------- ---------------------------------------Y-----------------VGKK----------- ------------------------------------------------------------------------ ----------------------------------D------------------------------------- ----------------------------HVHH-SMQS-----LSFN---MYR--------NLM-----VQG- --------N-RIT-SPHWSLRFIFFF------WYL-----FCFYIYAMYSG-----TL-----TA-VLAVPA F--EK-----------------------PID-----SLEHLAQAHHD-------------------GYTI-- -----------GTTRD---------SSFED----------------AF----K------------------- -------------G----------------------------------AV-SG--------IYHEV------ -WKLFN--------HKDRDQ-------------------------------------SFLSTPAS--G---- FDMIL----------K-Q-------K-Y-V-YINAQLNSELIA----TQ--------------QGRAN---- -----YYIARET-FLP-QG-------------------------------------------------YGIA CSSG-S-P-------------------------FKEVFSNI-----------LLRLTEAGLVYK-------- ---W---------------ADNEV-------------NK-------------V---AK-NNSP--------- -------------------TSETGPTAIKIQHLQAAFFMLV-------------IGFAT-SAA----VFGGE IV---------------------------------AS-RL-------R-QNDKTTKLMEK------------ ------------------------------------------------------------------------ ------------------------------------VVSQTKDHPPQ------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------PR--TVSRGTWV-------------I---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_11789770/1-589 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------MTQV---VNPR----------PLH-------------- --------------------------------------VTAQ------------------------------ -------------------------------------------------------------------VMVLR C---------------------D----APSV-----------RQWLQGVP-------PH------------- ------RVIFL------LLCA--QQHVL-------------------------------------------- -----------------------EIF-----------HMM------------RED---ALEA---------- -----GK-TMWV-V----------------------------------------------VTLQDYT----- ------------------------------------------------------------------------ ----ASLAHT--------------------L----------------------------------------- ---------REHTEVLVVR----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------PGSA--------------------- -------------------GALTLLITFL-------------------------------------QHDNKV RFECLGSW---------------------------------------------------------------- ----------------------------------------------WTSQ-VKERNHLEEEE---------- -----------------------EVHLPLHLQQS-----L------YHHH-HNL----HTD----------- ----------FRGRQ-LRVAAVD------------------------------------------------- ---------NW-------------------------------------------------P--------WFG -----------------------------------------LT-----E----------------------- ------------AD-D-------------G--------------------------TTVSDSGID-V----- ------------SILNTLSQ-K----------------------L----N----------F----------- ------------T----YRVVV-QED---------GQ-WGG------------------------------- -----------------------------SQPDG---------------T---V------------------ TG------------------------MIG---VV--------------AR-Q--------------E---AH LAID-----------------------------------------------------------EITIT---- -AAR---KTV--V-----------DF-T-RP-----YFMES---SAC-------------I-SRA------- --------------------------------PEE-KS--RAF-------------AVLSP---FT------ ----------------------------------TEV--W-LSI-ALS-------VI-G---IS-----IVL FLI--------------------------------------------------------------------- ---------------------GFL-IGQ-------------------------------------------- ---------------------------------------Y-----------------QEEE----------- ------------------------------------------------------------------------ ----------------------------------E------------------------------------- ----------------------------DAVL-SLQE-----VTFN---MYR--------NLV-----VQG- --------N-RLP-TVQWPLRCVLVA------WYL-----YCYYVYALYSG-----TL-----TA-VLAIPA F--EK-----------------------PID-----TLSDVLEATRH-------------------GFYP-- -----------VVIKE---------SSIDY----------------MF----K------------------- -------------V----------------------------------AT-SG--------IYHDI------ -GRLI-----------TSDK-------------------------------------NYVDAPPN--G---- VASVL----------L-G-------K-A-A-YIDARLSSEIQM----MI--------------QGREK---- -----FFIGRQS-FFP-QS-------------------------------------------------YGIV CSKG-A-F-------------------------YRDVFDRV-----------LERIVEAGLVDK-------- ---W---------------KTDEI-------------LK-------------L---GQGASSAGGLGRA--- -------------------KRGRGPRAITLTHLQGSFFVYV-------------MGLAL-ALL----TLLME QV---------------------------------V------------------------------------ ------------------------------------------------------------------------ ------------------------------------NGSHSSYRPKS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------SPSR--------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_11823054/1-764 ------------------------------------------------------------------------ ------------------------------------------------------MTSLKLSLLLLITACWVC C-------------------VDNSPSAA----------------------YYYPT---PSA--------TPT YPT--------------------------------------------------------NASPTLTYP---- ------------------------------------------------------------------------ ---IRMPTPTYPKDVSPTYPKNISPT-------PIHTSTPPSTPI--------------------------- ---NRSTPSLTPRT--------------------RAT--DTPTRSSGTMGANTN------------------ --------------------------------------------------------------------LPSP AAVTLLQGN-----------------RVAAQQLSRVVV-------------------QQGGKLAGTT----- --------------SETTKEGELVK--------FLARG---ASRR----------HLY-------------- --------------------------------------IMYD-SEW-------------------------- --------------------PGSAA-AVK--TC----SDAWVD------------------------VVATR C--------------------------DSDL-----------GFLERALH-TTTEGEEM------------- ------RIVII-------FCL--PERIL-------------------------------------------- -----------------------DVF-----------RMV------------RAR---SLES---------- -----ST-VQWV-V----------------------------------------------VVVMEET----- ------------------------------------------------------------------------ ----QHLSTHL----------------THLL----------------------------------------- ---------REGTQLAVLT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------AMADG-------------------- ------------------GHQYVATTSFV-------------------------------------DVDDTV RFEHRGVL---------------------------------------------------------------- ---------------------------------------------TVSE--EGSD----------------- ----------------------------LYLKTQ-----L------FPAL-DHL----YRD----------- ----------FRGRQ-LVVSVLN------------------------------------------------- ---------NW-------------------------------------------------P--------FFG -----------------------------------------LR-----Y----------------------- ------------LP-D-------------G--------------------------KPLADSGLD-I----- ------------SVLNSLSH-K----------------------F----N----------F----------- ------------T----YVVAE-PED---------GQ-WGG------------------------------- -----------------------------PQPDG---------------S---V------------------ TG------------------------IIG---MV--------------AR-H--------------E---AH LAIN-----------------------------------------------------------EITIT---- -ASR---EKV--V-----------DF-T-HP-----YFLES---TIL-------------V-SRA------- --------------------------------PAP-KN--KAF-------------AIFSP---FT------ ----------------------------------PLM--W-SLL-AAT-------TA-L---MG-----PLV WIL--------------------------------------------------------------------- ---------------------TTV-LRS-------------------------------------------- ---------------------------------------Y-----------------TNHE----------- ------------------------------------------------------------------------ --------------------------------------------EQHSLM-----NTPI------------- ----------------------------PPRS-SVQD-----LAFN---MYR--------SMV-----WQG- --------N-KIQ-VKNWSLRLLFFT------WYL-----FCYIIYAIYSG-----TL-----TA-FLAIPS F--ER-----------------------PVD-----SLIDLLHATRY-------------------DFVP-- -----------GFLVG---------SSNEF----------------LF----K------------------- -------------E----------------------------------AK-TG--------IFRKV------ -WEAR-----------HPTR-------------------------------------SFSPTIDH--A---- MDMVL----------K-D-------K-Q-V-FVNARLGSVIRS----MV--------------RGREN---- -----YHLGRQT-MYP-QS-------------------------------------------------YGVA CKSG-A-P-------------------------YKKVFERV-----------LLRTVESGLVDK-------- ---W---------------TQDQV-------------NT-------------V---VKMTTAEHDT------ ---------------------LKGPEPISLNHLQGAFLILG-------------MGYLS-AIL----VFLAH VI---------------------------------LR-S--------------------------------- -------------------WCN-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------TGD------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_11971069/1-738 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------MVGSSMTGLLL---------------------------------- ----------------------LAS--------LLCEAQP---------------NLNK------------- -------------------Q--PISACWDA--------VQEE-EPQP------------------------- ------------------------------------------------------------------------ ------------------------APASEDFV---------------------------------------- ----RMARFVV------EFAK--LIKIN-EVYFCLMGETGLPN----------------------------- -------------------GVIKRIF-------------------A------------SILSQ--------- --------HMMFFMPCDLS----------------------------------RMMGSINALDAGAT----- ------------------------------------------------------------------------ --PEDSVPQFL---------------FHPAVLHL--------TT---------------------------- ---------RKSLATTLITLWKQNLSDHFG--------------------------ALHII----------- --------------------------------------------------------MGVDLPPCQ------- ------------------------------------------------VQLEVTA----------------- ------------------------------------------------------------------------ ---------------RWFQSSYNLNTKEVMTDEVFL--F---------------------------NDGRES LHVPVTKW--------------------------------------------------HPHSTKTHS----- --------------------------------------------ITILHE---------------------- -----------------------------------------------PDV-G------PED----------- ----------FQGHA-IQVIAMD------------------------------------------------- ---------------------------------------------------------Y-SPQ-------ITK ------------------------------SK----PCKMVLS----PKDD--------------------- ----LHENVCHKNRIEGVM---------LGRS----------------------NKETAYYEGYL-V----- ------------DVIYTMST-A----------------------L----N----------F----------- ------------R----VNLSVLPPES--------AE-FGI------------------------------- -----------------------------DNGDG---------------N---Y------------------ SG------------------------LVG---AL--------------QS-R--------------K---TD IALV-----------------------------------------------------------GLSMT---- -RER---YQI--M-----------DF-S-EP-----IAYTG---MGL----F--------VWTNS------- ----------------------------------------SLHT--------IGWNTFVLS---FH------ ----------------------------------WGT--W-LAI-ILL-------LA-V---MT-----AGF WFIVQQ------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------QRNEDP----------- ------------------------------------------------------------------------ ---------------------------------------HFN------------------------------ ---------------------------------NGHN-----VIFI---FFS--------CLV-----QQG- --------S-WIL-PTTGRAQGVLWM------FWF-----SSVVLYASYTA-----RL-----TS-FLTVSS I--RL-----------------------PFS-----SLEQAVNT----------------------PGWK-- -----------IGILK---------GTSTI---------------QTL----E------------------- -------------V-------------ELMWLLSLGSLQR--------SQ-KD--------YYKKL------ -YKGLKQN---PSP--------------------------------------------LFSSEIE--G---- INRVL----------T-E------PK-Y-A-VFTDQLSMEFLL--------------------RGNCS---- -----IKQVPGS-YLA------------------------------------------GY--------LHLG LRKR-L-P-------------------------YATVLNKE-----------LIKMSSGGLLDR-------M HQHW---------------WGKSIPC--------E-APS--------------------------------- -------P----------------YTELGFSNILTAFMLLL-------------AGAVI-SLL----ILMVE LY---------------------------------FK-RR-------S-TKVLWSRK--------------- --------------------VR-----------------------HG------------------------- ---------------------------------TDASVSQQLRYRKSDIRHSY------------------- ---------------------------------------------------GRTIL---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------DIKKSKQMTDLDISRR-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_1267926/1-729 ------------------------------------------------------------------------ M----------------------------------------------------KPRVLLCIIVLIRHLWMLC G-------------------AEECGVE--------------------------------SAIC-----ETPA KPS--------------------------------------------------------GAVGVLA------ ------------------------------------------------------------------------ -----NPSAT-------RLPVIGPAV-------ALH------------------------------------ ----------------------------------------SLYHIVGEENTEKN------------------ ------------------------------------------------------------------------ ---------------------------------ESVLV-----------------S---------------- ----------------------LLS--------FLLQQ---TYRR----------RVY-------------- --------------------------------------IIYD-DFF-------------------------- --------------------PGVSK-TVK--SC----YKTWSD------------------------ITILK Y--------------------------DSNP-----------TQLEETFG-SPYHGGET------------- ------QTVVT-------LCS--PNNTN-------------------------------------------- -----------------------NIF-----------RVV------------RQH---SLES---------- -----PS-IRWL-V----------------------------------------------IVEDDII----- ------------------------------------------------------------------------ ----NSLQES--------------------L----------------------------------------- ---------REGTQVGMAV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------RVSD--------------------- -------------------TRYSIHSSYI-------------------------------------HPDNTI RFEVIGLWDDL------------------------------------------------------------- -----------------------------------------------RTS-SGSK----------------- ----------------------------GHIFQP-----M------FPDL-DIL----YLD----------- ----------FMGRE-MTVAAVS------------------------------------------------- ---------NW-------------------------------------------------P--------WFK -----------------------------------------LK-----Y----------------------- ------------LE-D-------------G--------------------------TPLPDAGID-V----- ------------NVITTLSH-K----------------------L----N----------F----------- ------------T----MRVVE-PED---------RG-WGG------------------------------- -----------------------------PKPDG---------------R---I------------------ TG------------------------MVG---MV--------------AR-H--------------E---AN FAIN-----------------------------------------------------------EFSVT---- -RLR---ETV--V-----------DF-T-NP-----YYLES---TTL-------------T-SRA------- --------------------------------PKE-KN--RGL-------------AIFHP---FS------ ----------------------------------YQL--W-ILL-ILV-------TI-F---MG-----PLG YLA--------------------------------------------------------------------- ---------------------TWS-HDHCLQK---------------------------------------- ------------------------------------LRLL-----------------VLGD----------- ------------------------------------------------------------------------ ----------------------------------GTVC-----VNESKVA-----ENVI---------DISS KDVL----VGGMSYS----NQSSSKSGRTWKA-VMAT-----YSFN---MFR--------SVL-----NQG- --------N-FIY-AKAWPIRLVLFS------WYA-----FCIIMYALYSG-----TL-----TA-YLTKPT F--EK-----------------------PID-----SLEDLEEATQG-------------------RLVP-- -----------AIQQG---------TSLEE----------------LL----K------------------- -------------T----------------------------------AE-FG--------IFKRL------ -WDTT-----------DPSR-------------------------------------SFPSGGKQ--A---- MDMVL----------T-H-------D-I-V-YISAKINSEIRA----AQ--------------KGRNH---- -----FYHARQT-FFP-QS-------------------------------------------------YGIV CTSG-A-P-------------------------FKNRFDSE-----------LGKMVQAGLINK-------- ---W---------------MRDEL-------------EK-------------L---RKSMKNRDDQAE---- --------------------STVAGGALSLDHLQGAFFILA-------------SGCFL-SAV----IFFLE -----------------------------------------------------TTKGCV------------- ------------------------------------------------------------------------ ------------------------------------------SRPSTE------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------PPR---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_1272334/1-668 ------------------------------------------------------MDG--------------- --------------------------------------------------RK-TCLMVVSLVATVGCCSG-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------FLQSPEGQEF---------------------------------- ----------------------FTA--------YVSAIDV-------------------------------- ------------------------MGINIF--------LPAN-RQ-G------------------------- --------------------EVVPVGMLR--ALWLQS---------------------------PLSVALQQ VRSSKEVKTTL-----------------------------------EAL----------------------- --------------------N--SNTLN--VAFLNTPEDL-------------------------------- -----------------------SLF----------VEVTLA-------S-LVRR----------------- --------HLWLVM----------------------------------------------GDTRLVT----- ------------------------------------------------------------------------ ----------------------------DGDHKP--------RL---------------------------- ---------PLDNLVTFAT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------VNTTNL------------------ -------------------TKVDLVEVYS---------V---------------------------SDDLPY TIRQFGSW--------------------------------------------------RAGGPVR------- ------------------------------------------------------------------------ --------------------------------LS---Q-K------DWSD-R------RSN----------- ----------LTGLH-LRCVTLP------------------------------------------------- ---------------------------------------------------------Q-QP--------FTY -----------------------------------------LS----------------------------- ---------------E-----------------------------------PDSQMNVQITGGYT-K----- ------------DVWDALQE-I----------------------H----G----------F----------- ------------T----YSCRV-PED---------GK-WGA------------------------------- -----------------------------LS-DG---------------K---W------------------ NG------------------------LVQ---EM--------------VE-Q--------------R---AD AVVS-----------------------------------------------------------SLDHT---- -GAR---AKA--V-----------HF-V-TG-----LREVG---YRL-------------V-VRR------- --------------------------------PGL-M--DQTWT------------SFTSE---LL------ ----------------------------------PDA--W-LGT-MAF-------VL-L---AP-----PCL VLCAHY------------------------------------------------------------------ --------------------S--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------PLET-EKV------------------------------ ---------------------------------TLKD-----AYIL---AVG--------AFA-----IQG- --------S-WLD-VRSISSRIVFIT------IFL-----ATLVVYAHYTS-----AL-----VS-LLTVAS T--NT-----------------------GFS-----TLQALLQDGS--FQ---------------------- -----------FGFIS---------GTSLE---------------VEF----R------------------- -------------N----------------------------------AD-QW--------LFKEV------ -WERLVVP---DP------L-------------------------------------NLVTTHQE--G---- INKVI----------N-E-------R-Y-V-YMMEENEFRAMIGNQ--------------------CQ---- -----VVLTKSQ-YFS-TQ-------------------------------------------------TGFA VATD-S-P-------------------------LKKVFDTQ-----------LLRMRDGGVLSR-------- ---S---------------WQKWQ-------------PPPAL----------------CTDQGVV------- --------------------------ALDLSHLFTAFLLLV-------------LGVVL-AVI----ILPCE RL-------------------------------------H-------W-KVVGGT----------------- ------------------------------------------------------------------------ -----------------------------------KAARSKQLFSQALSQ---------------------- ------------------------------------------------------------------------ ---------------------------------------------------GLQGDSDA-TKET-------- ------TQRNTDPIR----------VAHL------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------QEPGEFIT-DRGFRQYTSHLR-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_1546221/1-692 -----------MYPG-------------------------------------RAMDNNV----QV---LPRQ G----------------------------------------------------RFMRLMRHVVFVMVLQKSF K----------------MTIATSTLHSH--------------L--------------------------VPS TPR-------------------------------------------------------------------LG KFSDRV------------------------------------------------------------------ ------------------------------------------------------------------------ -------LGSINSSYF-------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------TSTTESTRLTD-----------------SS----VLSQ------- ----------------------LMT--------FILGL---SSGR----------QIY-------------- --------------------------------------VISD-DSW-------------------------- --------------------PDMTV-VMK--SC----YQEWAD------------------------TTLLK Y--------------------------DPKL-----------TELESSLK-SPNHVVAM------------- ------RNVIV-------LCS--TQHTL-------------------------------------------- -----------------------YLF-----------QQV------------REK---VLES---------- -----TT-VQWF-V----------------------------------------------VVMEDLT----- ------------------------------------------------------------------------ ----FILQHS--------------------L----------------------------------------- ---------REGAQVSIFI----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------R---D-------------------- -----------------TVTKYKLLVARV-------------------------------------NTQGQV RLEAAGWW---------------------------------------------------------------- ---------------------------------------------KIGAD-GTPTT---------------- ----------------------------S-LSLQ-----L------VPDL-LQL----YSN----------- ----------FHGRQ-LVVSVNN------------------------------------------------- ---------NW-------------------------------------------------P--------FLG -----------------------------------------II-----H----------------------- ------------QE-D-------------G--------------------------SVVPDSGID-I----- ------------NILDTLGS-K----------------------L----N----------F----------- ------------T----YELVV-PED---------RA-WGG------------------------------- -----------------------------PQKDG---------------T---V------------------ TG------------------------LIG---MV--------------AR-Q--------------E---AN LAIC-----------------------------------------------------------EITIT---- -DLR---ETV--V-----------DF-T-AP-----YWLES---LTL-------------V-SRA------- --------------------------------PKE-RD--SSM-------------AIFWP---FT------ ----------------------------------TMV--W-VYI-AVA-------TL-V---MG-----PVM SVLYWF------------------------------------------------------------------ --------------------RGWL-VER-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------NKRRH--KLHQ-----LSFN---MFR--------SLV-----LQG- --------N-PLP-VNNWPTRLVFIT------WYL-----FCYNIYAFYAG-----IL-----TA-VLTVPV F--EK-----------------------PVD-----SLADLPLAAGE-------------------GFAI-- -----------GTLKD---------SSTET----------------LF----R------------------- -------------Q----------------------------------AE-SG--------IYYQV------ -WQLF-----------HPVD-------------------------------------SLLPDPEL--G---- FDKVL----------G-E-------K-F-V-LINSQLNAEIRA----TV--------------RGRDK---- -----YHFSRET-FYP-HG-------------------------------------------------YSIA CTTG-A-P-------------------------FRPNFERM-----------LSGIIEAGLINH-------- ---W---------------AEGEI-------------QK-------------L---SG-KVDTDGDE----- -------------------TEDGGPSSLTVQHLQAAFFLLA-------------LGGAT-SSA----AFLVE ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------VLLALRQSAELPD------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------FFPAAQ-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_1716353/1-641 ----MAIS-VRC---------------------------------------R-------------------- -------------------------------------------------WQV-LVVVMAVARWVLPMVGAHP ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------RVVQMMQDVIT---------------------------------- ----------------------HKKW------DYVTLLYT-------------------------------- ------------------------NNNHTM--------TTIE-AS--------------------------- ---------------------EVLAGLVS--SM---------------------------------SAAIIY LPNLQQLSLGFT----------------YS----------------------GGDTWTNINIR--------- -QPHYRAQFIT-------IWD--NEGHA--AAFMNKAGHL-------------------------------- -----------------------GLF----------TQ----------------Q----------------- --------QEWLIL----------------------------------------------LPHNTTI----- ------------------------------------------------------------------------ ---Y-DME--------------------NLLKDA--------EI---------------------------- ---------FIDSEVLVCS----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------YDSKMESF------------------ -------------------ILREAWRGGR---------------------------------------GQPF QEGSWGMW--------------------------------------------------SEEKGLV------- ------------------------------------------------------------------------ -------------------------------TAP---M-N------NKYE-R------RKD----------- ----------LRGFH-LRVATIV------------------------------------------------- ---------------------------------------------------------T-MP--------YES -----------------------------------------LV----------------------------- ---------------A-------------------------------------DQQLQNFREGYV-V----- ------------DVWHTLQE-Q----------------------L----N----------F----------- ------------T----YT----ATN---------TL-FGS------------------------------- -----------------------------LQPDG--------------VT---W------------------ NG------------------------MVG---ML--------------QT-D--------------D---AD VAVA-----------------------------------------------------------PLSIT---- -KIR---SIS--I-----------DF-T-IP-----IQIVS---TRL-------------Y-IRR------- --------------------------------PIL----EGTWT------------LYGQP---FG------ ----------------------------------GYL--W-MCI-PVS-------IV-V---CA-----GML WGLNWL------------------------------------------------------------------ --------------------TVY------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------LKVND-HII------------------------------ ---------------------------------LPLE-----ALWI---MFS--------GLV-----QQS- --------T-VID-PRPVSGKIVFFS------GMW-----MGMILLTCYSA-----IL-----VS-ILTTRQ P--KL-----------------------PFK-----DFQALLDNPD--WN---------------------- -----------LGVRT---------NTALA---------------DSL----A------------------- -------------L----------------------------------APPNS--------PMRLS------ -WEHIVGK---DP-----AN-------------------------------------NLPSNNDD--A---- LTNVL----------K-G-------K-Y-A-FFANKEYIIYRLQRKLPL--------------KQAMD---- -----IVDTNTD-FLK-RG-------------------------------------------------IGFG LQKE-S-P-------------------------YKNLFNYV-----------LTKMTQKGHLNR-------- ---L---------------KRKWW-------------PNIDR----------------NPDPHYP------- --------------------------TPGFNEVFTLFIILG-------------AGTIL-AVV----FLMCE WF---------------------------------I---Y--------------S----------------- ------------------------------------------------------------------------ -----------------------------------KSRRVIS------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------WS----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_1878980/1-764 ------------------------------------------------------------------------ ---------------------------------------------------------------MLRSVATIC ----------------------------------------------------------------------PL Y--------------------------------------------------------------CLLFE---- ------------------------------------------------------------------------ ---YGAGMAT-AVNV----NLNDNSS-------VLHRSAD-------------------------------- -----------------------------------II--DTSFDTTDTSSNTTD------------------ --------------------------------------------------------------------TSSD TTDSLNPGNY-----------WQGKTDITSIVATRLMS-----------------GTKAGQHLAA------- ----------------------LVD--------FLVNG---STGR----------QLY-------------- --------------------------------------LLHD-HSL-------------------------- --------------------TDMSP-AVE--AC----YRRWGD------------------------VIIFK F--------------------------TWEL-----------TEVEAALR-SNYHFQEL------------- ------RNILV-------ICS--DVHTT-------------------------------------------- -----------------------HIF-----------QQI------------RER---SLES---------- -----AT-LYWY-I----------------------------------------------VLFDDIT----- ------------------------------------------------------------------------ ----EQILDS--------------------I----------------------------------------- ---------REGTQFSLAV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------R-KD--------------------- -------------------HRYQLFTSFV-------------------------------------DSDNNI ALDHRGWW---------------------------------------------------------------- ---------------------------------------------SWNA--DQGKP---------------- ---------------------------IKYLKKP-----L------YLNL-SDV----YRN----------- ----------FGGRV-LRVAVVD------------------------------------------------- ---------NW-------------------------------------------------P--------YFK -----------------------------------------VT-----R----------------------- ------------SE-D-------------G--------------------------SLQPHSGVD-Y----- ------------NVLNALAK-K----------------------L----N----------F----------- ------------T----YELVD-TLD---------GQ-WGG------------------------------- -----------------------------VMDNG---------------T---V------------------ TG------------------------MIG---LV--------------AR-H--------------E---AH LAIN-----------------------------------------------------------EITIS---- -GTR---EKV--V-----------DF-T-AP-----YFLES---TTV-------------I-SQA------- --------------------------------PAM-KN--RAF-------------AVFSP---FT------ ----------------------------------VRI--W-LMV-VAM-------TM-L---MG-----PIL SVV--------------------------------------------------------------------- ---------------------GLV-RAR-------------------------------------------- ---------------------------------------Y-----------------L-HE----------- ------------------------------------------------------------------------ ----------------------------------G------------------------------------- -----------------------------VRY-SLLT-----YAFN---VFR--------SLV-----VQN- --------N-LIS-SQHWEQRIIFFA------WYF-----FCFTIYAMYSG-----TL-----TA-VLAIPA Y--ER-----------------------PID-----SLPDLVHAAKH------------------KGYKP-- -----------VVVYG---------TVNEF----------------LL----K------------------- -------------E----------------------------------AE-DG--------IYKEV------ -WDVF-----------DPSE-------------------------------------GYVNTYTD--G---- TNKVL----------T-G-------K-F-V-FINARLGAEIRA----IA--------------KGRHR---- -----FYLGKSS-FYP-QG-------------------------------------------------YGIA CTSG-S-P-------------------------FKNVIEQI-----------LTHLGSAGLVQK-------- ---W---------------IRDEM-------------EK-------------E---SNHDDGANK------- -----------------------GPGAISFVHLQAAFFLLG-------------MGSFV-GGL----TLLME RF---------------------------------VY-SR-------Q-ATFVTVYGHTKAATNS------- ---------------KVAEMTRIHGDNLGEDP-------------PG------------------------- --------------------------------PQVYREIDKDERPYTSS----------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------MD--- -----FMRVQVSPE-PERKSSAGD-------------TTDSEHK---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >HaztIr127/1-882 ------------------------------------------------------------------------ -------------------------------------------------------MRLTAVVL--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------AGFTLWHLSH ------------------------------------------------------------------------ ----------------------------------------------------GV------------------ ------------------------PKLNSSKLRNQLAPQDVT-------------PTV-------------- ------------------------------IAEVVEKYGG-------------------------------- ---------------------GRTGPCQLL--------LYFD------------------------------ -------------------QKTVSNEQLR--QLQAVL---------------------------GSPIMLLD VTNIRLGLITAQR-------------------------GPPVMPKVDLLT-NRPEKETCRVLLSWS------ -EAGHQRGLLV-------LAK-LLPDIV-------------------------------------------- -------------------RQEDTLILT--------TEYK------------------NIGSF--------- ----IPELNRRIVVRKNETPG--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------KNASQVRFVV----------------------------------------------------- ------------------------------------------------------------EQSCL------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------SCG-YSP------------------------------------------------ AMEKIGEL---------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------G--------EYAG-LTWKR-RSKN----------- --------PSLLGKK-IRVTYTP------------------------------------------------- ---------------------------------------------------------S-VPN------IYTT ------------------------------------------------------------------------ ---------------S-----------------------------------------EGVLDGLE-Y----- ------------RMLQYAAE-A----------------------L----N----------F----------- ------------T----YVLQI-PAD---------NE-WGRFI----------------------------- --------------------------------NG---------------S---W------------------ TG------------------------KVG---DL--------------VN-N--------------R---SD LAIG-----------------------------------------------------------GIVYK---- -SQR---SAV--A-----------LY-S------TMFHQEL---WSI-------------V----------- C-------------------------------PRP-TK-LPLWP------------YIMFP---FR------ ----------------------SEKA--------PSV--FTFLV-----------LL-----------HIVA FIIASF------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------AS---------------------------------- ---------------------------------SVKQRN-----------------------------RQN- --DT----------PFMKSVKNIFLVA-----GSF-----YWRIMACLYFW-----NLFY------CILEPQ Y--EE-----------------------PIN-----SSIALLDSAKK------------------------- -----------YGLVR---------GTTVE---------------TVL----A------------------- ------------------------------------------------SSLDA--------SQQKL------ ----------------ARDA-------------------------------------RRLSSISE--G---- FFNLD---------TN-GMCIVGVPKRY-A-------------------------ESTIRTRYTTQCG---- --EPAIQVSSEN-LHT------------------------------VL--------------------GGWL MASK-S-P-------------------------LKEKLDPI-----------IVRLQSFGFLNK-------- ---WQA-----D-------LYDSL-------------SRS------------RDEKLPCVVQP--------- ------------------------VGSLSFYDLRLAFLLLL-------------VGWGA-ALV----LLGAE YAANYFIQKLEDEFGPMHGDHNTSMNYRRAHTQRTWAERVLRQIAPHR-QQIRRPIATDAELRRRMYMFFKE MTEPDFLHPQVTIRPPRVAEARSL-PHSKSQTVIVH------------------------------------ ------------------------HQAPNSVSKKTYPIQPTSAHASAAAR---------------------- ------------------------------------------------------------------------ -----------------------------------------------------RAPLDVVSKQATSITEVRP YEIPLSRAARVPPLQRNYSSRKTS------------------------------------------------ --------------------------------------------------R-RKRLRLPNI----------- --------PNSPVNALPRLRDPLVR------FFSAKQRVQNLIPRDSDGGDSSARLKSSLHLTRKRLL---- ------------------------------------------------------------------------ -----HHSASR--------------------NEKSMDLVSPSDPEQREINNDK------------------- -------EDSID----------------------DI------------------------------------ >HaztIr128/1-671 ------------------------------------------------------MTASFM------------ ------------------------------------------------------VVSVLLFVFVPESFADLR L----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LWRSTEHASAESPDQEDL---------------------------------- ----------------------IMW--------ASKQQGL-------------------------------- ------------------------NRCAGL--------ILYD-TQ-G------------------------- --------------------GASAASHIS--EA----------------------------NVFPQGTMIVD AAKISAVQALHY-------------VALGSLG---------GS--CSSV----------------------- ---------LL-------LLT--SV-------------SW-------------------------------- -----------------------RAM----------LDASGAAR-TLADSWARNR----------------- --------RVFAVMQ------------------------------------------AATLSKQAMS----- ------------------------------------------------------------------------ ---D-QASNNE----------------RDLLLHS--------VL---------------------------- ---------RKSVQLVLC------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------SYDPHN------------------ -------------------NLWRLFRSVL---------Y---------------------------RGPHRH TSALIATY--------------------------------------------------HRDAGVRW------ ------------------------------------------------------------------------ ------------------------------TQGS---E-L------FSDR-R------FQD----------- ----------FEGYK-FTIAALP------------------------------------------------- ---------------------------------------------------------Y-SP--------FII -----------------------------------------EA----------------------------- ---------------N------------------------------------GAYAGPGKYSGLE-V----- ------------RLIDTLAS-V----------------------A----N----------F----------- ------------T----YEYKA-PSD---------GE-WGR------------------------------- -----------------------------LSPNG---------------S---W------------------ SG------------------------MIG---LV--------------DR-Q--------------E---AD WAVS-----------------------------------------------------------DITFS---- -PER---AGY--V-----------TF-S-ST-----FVYDA---SEL-------------L-TPR------- --------------------------------ALP----LPLFL------------GPVKP---FT------ ----------------------------------LVV--W-VAV-AAA-------IA-L---SG-----PLL YIIVRT------------------------------------------------------------------ --------------------SPA------------------------------------------------- -------------------------------------HDH-----------------DA------------- ------------------------------------------------------------------------ ---------------------------------------WFL------------------------------ ---------------------------------TPAH-----AVMY---TLQ--------PVF-----NHG- --------C-HKD-LSGNSSRVFALF------WLL-----SAMIISILYSS-----SL-----TA-FLILPG Y--TK-----------------------PIM-----NLEQLVNSHIG-WGKVNFGGVQNALLEQTKDPVL-- -----------IRLRE---------GVQWY---------------RSL------------------------ ---------------------------------------------------DS--------ILKEVVAGKLA TWDNRITT---RL-----EI-------------------------------------AVHFTDKS--G---- QPLVT----------L-T-------G-F-E-LLQER------------------------------------ --------------------------------------------------------------------IAWP MTRL-A-P-------------------------FKCRFDEL-----------IQRARQAGLVEKWLRHVISE QQVQ---------------AKQEQ-------------NSQLQ-------TAGNEGGG--EAGGVV------- --------------------------VLSLDHFQGVFLVLV-------------FGCFV-GGF----AFVGE LV---------------------------------FH-RY-------H-GMG-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------YARHRRG---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >HaztIr130/1-731 ------------------------------------------------------MLKID------------- -------------------------------------------------NVN-RLAGIFGFSTITIFRLLL- -----------------------------------------------------------------IIYCIDR SIGNE------------------------------------------------------------------- ------------------------------------------------------------------------ --------------THDVFHEVASYNV--------------------------------------------- ---------I-TKPNYN--NLHV------------------GYLNHLLN----------------------- ----------------------------------------------------------------------TT ATSEII------------SNDVGNFNLDSGNFDSSLRSDQHNLLFNSTSKLLKLFPYANLEHIQPTTFH--- --GFNSSKISPTL---TTDQLTVAS--------FLASQYS-------------------------------- ------------------------QKCLKV--------SVGL-A---------------------------- --------------------------------------------------------------WSNEPHILLK DD-----------------------EDGMSI-----------LSSLKETT-QGYSKNNC------------- 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-------------------NPLIG------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------QR-----A------------------------------ ---------------------------------TFSQ-----SCLD---IFG--------SFL-----SQN- --------L-QRI-PSKTMTQVFIAT------WLI-----YGLLTTTYYKS-----AL-----MA-VLAVPT T--PP-----------------------TLN-----TLQELY-----------------------DSKIQ-- -----------YGMID---------AKGSEY--------------QLF----S------------------- -------------T----------------------------------SK-ID--------LYQKL------ -FQKMS----------------------------------------------------FYSSKES------- MRRVA----------E-G-------S-Y-A-YIYFRANIESIVMSEYTDR-------------AGQTY---- -----MHIAAEN-FFP------------------------------------------GG--------YAWA FPKG-A-P-------------------------YMRTIDQL-----------MQRCLQAGLVSR-------- 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------------------------------------------------------------------------ --------------------------------------------------------MQNVEIVRR------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------RIRLASP----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------NTKFAE---------------------------------- ----------------------TRA--------SKYERKA-------------------------------- ------------------------ANAR-------------------------------------------- ----------------------VEAGAGR--HLGGR----------------------------QQISLRLD CRG-----------RWAGPIADHKAKEGST----------------SSVR-SYTEHHVC------------- 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------------------------------------------------------------------------ -------------------------------------------------------------MKLSKTYAFK- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------QSRRL-----LRV---------------------------------- ---------------------------------EFSEQG------------------E-------------- -----------------------------I--------MFYK-D---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------NPYTG-------------------------------------------- ---------------------VYRRL---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -ITSLKNW--------------------------------------------------NS------------ ------------------------------------------------------------------------ -------------------------------NAK---D-L------FEDK--------LTD----------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------MDE--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------SSTSSGTDPIEF-----------------PLG-------------- ----------------------LLE--------KLVGE---FDGS----------HVL-------------- --------------------------------------LLQS-AAQ-------------------------- --------------------AGDERDLTA--TL----------------------------------AALWR L----------------------S-V-DTRL-----------DTCGSLLQQNQVLAHSK------------- 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------------------------------------------------------MDE--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------CASSPGVDQILL-----------------PSR-------------- ----------------------LLE--------EIIWE---FNGN----------HAM-------------- --------------------------------------ILHS-QPH-------------------------- --------------------AGDERDLTA--TL----------------------------------AALWR L----------------------S-V-DTRL-----------DTCGSLLQQNQVLAHSK------------- 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---------------------SVC-QQR-LG----------------------------------------- ---------------------------------------L-----------------RTEP----------- ------------------------------------------------------------------------ ----------------------------------KRS----------------------------------- ---------------------------------SMSE-----FSFY---AFRL-------ALM-----QHD- --------E-SVA-IKTPSLRLFVIF------WAI-----FSFILTVLYSG-----HL-----TA-ALVSPP H--AR-----------------------PIS-----SLQDLLTAVTR------------------DGVLP-- -----------VVFEG---------GSAHA----------------VF----S------------------- -------------L----------------------------------SE-AD--------IYRNL------ -YQHF------------TAD-------------------------------------SYVTSTAD--G---- YKKVL----------T-S-------N-G-A-YIGGALSARIRT----LT--------------LGSYK---- -----FSVAREA-FSS-ES-------------------------------------------------YGIA VRTG-A-P-------------------------YLIAFNSA-----------LGRLVDSGLIGK-------- ---W---------------EREAV-------------AS-------------V---TRQSALQAATGELL-- -------------------------VSLNLHHLQGAFVFYA-------------MGMTL-ALI----CFLIE RY---------------------------------CS-GG-------A-RKQL------------------- ---------------------------LGIEH--------------G------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------FNCRSLKTTSG------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >HaztIr197/1-599 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------MLT----------------------------------------------- -----------------------------I--------IIYN-DTDD------------------------- --------------------------VQE--RLVLRLLRGIAG---------------------FGHVGVVQ LSDA--------------------------------------AHSWKPVK---------------------- 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----------------------------------------------------MKMRSLAT------------ --------------------D--------------------------------AAFLL-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------ASSGE-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------GLASLEDCAVAA---------------------------------- ---------------------------------VMRRWTA-------------------------------- --------------------EQGRQYVPVA--------VQYE-NTP-------------------------- -------------------------------GIYSSCTTT-------------------------MPMSVWG DEEGTSGR--------------------------------------HMLDNAAY-TREA------------- 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-------------------TANL------------------------------------------------- -----------------------------------------------------------KPR------VFET --------------LYA------------------------------------------------------- ---------------D-------------GKK----------------------RKDVTAAEGYI-V----- ------------DLVRIIGV-K----------------------L----N----------V----------- ------------S----LDMIV------------ASS-FGV------------------------------- -----------------------------LTSNG---------------T---W------------------ SG------------------------MMG---DL--------------VA-R--------------R---AS LSPL-----------------------------------------------------------DFSPS---- -LER---QAV--V-----------DF-S-EW-----LSMDP---VIL-------------I-SRS------- --------------------------------PSL-LT--VPF-------------LLLQI---FS------ ----------------------------------LPS--P-VCN-VAV------TLM-CFSSSR-----SQL YSLPL------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------TTA--------AIAK-SFILQG- --------K----------------------------------SVFA--TG-----SI-----IA-FLTVPR S--SK-----------------------PID-----SAEDLMARL---------------------DEVT-- -----------PVTRM---------NTVYS---------------NFI----L------------------- -------------N---------------------------------FPRFSP--------IAAKVE----- ----------------FMAD-------------------------------------DFLNTWQ-------F FELIQ----------S-G-------S-Y-C-LIDVVSSGVGRAASYETR--------------GQTCR---- -----FHESRQI-LKN------------------DI--------------------------------DMMA HASN-S-V-------------------------FRNRIDDI-----------IRQLRSFGLVEH-------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------MNIKVGFL------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ --------------------------------------------D--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------EPRD-----IVEI---PLR--------AIL-----SQG- --------Y-SPR-TGYFATRLLELV------TWA-----FTIPLVALYAG-----NL-----TA-SLSSPR F--EA-----------------------PVN-----SWSDLAARPDK------------------------- ----------------------------------IPVFFPNDPIHQLL----V------------------- -------------N----------------------------------KS--G--------VLGEI------ ----------------YRKA-------------------------------------IIPDNLIW--D--AI SRRVI-----------------------------RRAMVERATSINLADGR----------GLGRSCN---- -----VRMSDDS-VSF------------------SI--------------------------------IVLF GGRN-S-Q-------------------------FEEPFNKR-----------IRQLRSFGVVEKL------- ---YR-----------------------------------------------TFVRDGCYLQSGRRKRRDSG T---------------------ANPSRLTLEQLQGAFWLYI-------------LGNIL-ACV----VIFLE GV---------------------------------IH-RR-------Q-TKRN------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >HaztIr210F/1-696 ------------------------------------------------------MEK-----------LPHA L----------------------------------------------------APLFLPVMIFKLLGLQVIT C---------GA--------VDARSLSTRLV----------------------------------------- -------------------DVN-------------------------------------------------- ------------------------------------------------------------------------ -----------------NASLRQTSN-------ALTSQYF-------------------------------- ------DLLMVRSNALI------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------SRNQICGEGSS-----------------ASE-------------- -----------------------------------------TEGNRA------VLQLL-------------- --------------------------------------RLFQ-GTD-------------------------- --------------------AIIFA----------GQEDAEAEYYQR--------------HLRQRGKALRM Y--------------------------SCEA-----------PNLSDIVTRVAETASNE------------- 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------------------------------------------------------------------------ -------------------------------------SQY-----------------QKSK----------- ------------------------------------------------------------------------ ----------------------------------SLQ----------------------------------- --------------------------TERTQM-NLLV-----SIFT---ALR--------IVL-----NQD- --------N-RAE-PLTTPNRFLFGF------WYI-----FSCIVNALYAG-----TL-----TA-VLAVPT F--QR-----------------------PID-----SLNDLLNSVKK------------------DGVVP-- -----------VVTEG---------SSLQQ----------------LF----S------------------- -------------A----------------------------------AR-EG--------VYRDI------ -YERF-----------SGAD-------------------------------------SLTPSPDD--G---- VLKVL----------S-S-------K-S-A-LIEATLSMEIRA----TK--------------LGRER---- -----FHVGRQS-FYP-QA-------------------------------------------------YGIA CRKA-A-P-------------------------YLPAINVL-----------LSRMVEAGLIGK-------- ---W---------------KSVEV-------------KK-------------V---AQRSAGR--------- ------------------SYEDTRAGVLTLNHLQGAFIVYV-------------IGGIC-ATI----AIIVE VL---------------------------------WV-KI-------N-RHFEHQKTIRKSC---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >HaztIr212FI/1-602 ------------------------------------------------------------------------ ------------------------------------------------------------------MAWRLT R----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------EAKKSLDSKLVY-----------------PPPL------------- ----------------------LVR--------SLIEQL--KCNQ----------ALV-------------- --------------------------------------LRHE-QQ--------------------------- --------------------------TLE--ATF---------------------------------SALWS L--NAGVR-------------------IGAC-----------AHLTEAL--SGVSSGSS------------- 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---------------------SYA-QKR-------------------------------------------- --------------------------------------LH-----------------LRTE----------- ------------------------------------------------------------------------ ----------------------------------K---------------------NPL------------- ---------------------------------TVKE-----NAFN---AFK--------VLF-----MQA- --------V-SPI-PETAPLRLFAFF------WYI-----FSLNFVVLYSG-----NL-----TA-VFAAPP L--ES-----------------------SID-----TLGDLLVAARR------------------DGVLP-- -----------VTLKG---------SSLHA----------------LF----E------------------- -------------------------------------------------------------VYTAI------ -ITCY------------------------------------------------------------------- -IKVL----------T-S-------R-T-A-YIDSTLALEVRA----SM--------------RGRQK---- -----FHLGREK-FFA-QS-------------------------------------------------YTIA CTKG-A-P-------------------------FRIAFNSL-----------LSQMVESGLINK-------- ---W---------------KKEQL-------------DK-------------I---SSKTIESEPNPT---- -------------------------EAITLAHLQGAFFVYA-------------LGCGS-AAL----AFCAE RL---------------------------------HS-QR-------K-RS--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------GAPTASTLVKTLMN-------------NQDL------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >HaztIr213/1-633 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------MCN--TSDLV-------------------------------------------- -----------------------RIF-----------QQV------------SRE---SLEH---------- -----RR-VWWA-V----------------------------------------------VGEDAGL----- ------------------------------------------------------------------------ ----PKLLQGL-------------------I----------------------------------------- ---------REGVQMALLV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------ADAA--------------------- -------------------GRYKFYVAEV-------------------------------------SPLLGM RMKLLDHPPVLCATPG-------------CSLP----PSV-------GTTHPK-------AVP--------- --------------------------------------------ALYNSS-QMDQN---------------- ------------------------LDELSYRKPD---E-L------YRNP-DEV----YRN----------- 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------------------------------------------------------------------------ ---------------------------------------------------M-------------------- ------------------------------------------------------------------VANLPE ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------S------------- ------KITR------------------------------K------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------LMN--TWAPFRSLQ-----VA----------------ASASMRV-- -NNGNLTIT----------------KKNL------------------------------------------- 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----------LQGQV-VKVAVAHVSGGGGGSG------------------------------------SGGG GGGDGLGCSCW------------------------------------------VYLMY-PP--------FLD -----------------------------------------LS-----P----------------------- ------------GS-R-------------GLN-----------------------ISGTLGHGQA-W----- ------------DVLAALTG-H----------------------F----N----------F----------- ------------T----PRVVV-APT---------GG-VGA------------------------------- -----------------------------VGLTG---------------E---W------------------ DG----------------------------------------------------------------E---AE FSLL-----------------------------------------------------------PVALT---- -EAR---QAV--L-----------EF-T-AP-----LGTSS---YGA-------------L-VRR------- --------------------------------PGF-SP--KPD-------------ALLQP---FD------ ----------------------------------LKV--W-LVI-VAT-------LV-M---MG-----PLM YAVILT------------------------------------------------------------------ --------------------GVRL------------------------------------------------ ---------------------------------------G-----------------RRDA----------- ------------------------------------------------------------------------ ----------------------------------SSTH-AF------------------------------- ---------------------------------TLTQ-----CVWF---VYG--------ALM-----KQG- --------S-TLK-PLTDSSRILFAT------WWV-----YVVIVTSFYTA-----NL-----TA-FMTFNG L--KL-----------------------PVS-----SAAQLAQ-Y---------------------PAVS-- -----------WLALP---------DGALQ---------------QYV----Q------------------- -------------------------------------------------S-SP--------DVAVL------ -REMQRGG---RGQ--------------------------------------------LISSTDE--A---- VERVRR---AE-PWEA-G-------S-Y-V-YVDDVRVLKHVINRDYWQ-------------QVRSLP---- -----DSASHCH-FYW-TELVPED---------------------------------SASGGQSASFWWAFA FRKN-S-T-------------------------LRPAFSAF-----------LKRLDQHGILQF-------- ---L---------------HTNTT-------------PP-------------T---QVCELPRGF------- -----------------------KDRPLENKDFYATYVITV-------------LGALL-ASV----AFCTE H----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------GYR---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >HaztIr8aF/1-860 ----------MIW----------------------------------------QRR--------NS------ -------------------------------------------------------FKLSVQLLV-------- ----------------ACLYCRVTEGQL-------------------------------------------- --NIV------------------------------------------------------------------- -------------------------SIADESLQ--------------------------------------- ----------------QAGAWLAAGV-----------AAAEAATST----------------K-IALD---- --VLKISIEDETS---A--ENQLCSALF--------N-GVSGVL---------------------------- ---------------------------------------------------------------------DVT AGG----------------------WEYAKHAAARVGA-----------------PYVHGQVG--------- -------------------ITQHVH--------AVDDL---LHN-RN------ATDA--------------- -----------------------------A--------LIFT-TEAE------------------------- ---------------------------LD--QALYHLVGGS-----------------------SVRVIVLV -------------------------GLGSNS-----------TAALRRMRPAP-AY---------------- --------YVI-------FGS--GSDAA-------------------------------------------- -----------------------QLF-----------DQA------------ITQ---NFVT---------- ----RDS--RWTVA----------------------------------------------ITGTDP------ ---QNFVSKAMPSGTT--VTIMSPAAENCCVA-QNLPAPCA---------CTA------------------- ------------------------------V----------------------------------------- -----------NTPEQLIR----N--------------------------------LVLMM-T--------- ----KTLKSGN---------------------------------------------FSTVKGECS------- -SLP-Q-QGPSKQKFLDAFKT---------------------------EVS--------------------- --------GWKGAIW------------------------------TNETQELKV------------------ ------------------ANTFQYDA------------------------------------------VKGS VKTKIGSW--------------------------------------------------ATQTG--------- ------------------------------------------------------------------------ ---------------------------IQLEPLF------------------------ENT----------- ----------PIKRF-FRVGSVE------------------------------------------------- ---------------------------------------------------------S-RP--------WFY ------------------------------------------------KDSSP------------------- ------DGVSF-----------------------------------------------EGYKGYC-V----- ------------ELALRLAN-M----------------------M----E----------F----------- ------------D----FSFLT-PND---------GK-FGA------------------------------- -----------------------------KMANG---------------T---W------------------ NG------------------------LVA---DL--------------AN-G--------------D---TD LIVA-----------------------------------------------------------PLTMT---- -SER---EEV--I-----------DF-V-TPY----FDQSG---ISI-------------V-IRK------- --------------------------------PER-QE--NLFK-------------FMTV---LK------ ----------------------------------PEV--W-GSI-VAA-------LV-V---TG-----VML WLLDRY------------------------------------------------------------------ --------------------SPYS-AQN-------------------------------------------- -----N------------------------------ADKY-----------------P-------------- ------------------------------------------------------------------------ ----------------------------------ETCR-IF------------------------------- ---------------------------------TLKE-----SFWF---ALT--------SFT-----PQG- --------GGEA--PKALSGRTLVAA------YWL-----FVVLMLATFTA-----NL-----AA-FLTVER M--QS-----------------------PVQ-----SLEALARQA----------------------KIK-- -----------FTTTR---------DTSIY---------------EYF----F------------------- -------------NMARAEDELFRVWKELTLN---STTDQSKYRVWDYPI-KE--------QYTHI------ -LQVIEDT---GP----------------------------------------------VATAEE--A---- FKMVLDNTDG-----E-----------F-A-FIHDAAQIRY--------------------ELYHSCY---- -----LSEVGEP-FAE-QP-------------------------------------------------YAIA VQQG-S-Y-------------------------LQEELSRA-----------ILELQKERYFES-------- ---L---------------LAKFW-------------NS-------------S-ARGYCPNDDE-------- ------------------------SEGITLQSLGGVFIATL-------------IGLVL-ALL----ALGIE VM---------------------------------YN-KR-------V-GAGNR------------------ ------------------------------------------------------------------------ -----------------------------------SVVQD--INIK-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------QPVNMKNFDPNNMDL------ ------------------------------------------------------------------------ ----------------------------------------PMDREKIS------------------------ -------RISVA----------------------PVY----------------------------------- >LgigIR25a/1-890 ------------------------------------------------------------------------ ----------------------------------------------------------LMTVLIAYLN---- ----------------CLLHVRS------------------------------------------------Q THRI-------------------------------------------------------------------- -------------------------VVVIDNTI--------------------------------------- ---------------LEYNKNIEKIL-----------SNSDSLVDQ----------------G-VNLAQT-- -EFKIIIADK-NDSLVT--LDNVCAEMK--------K-GAVALI---------------------------- ---------------------------------------------------------------------DMS IPS---------------------SAVLLRSYASSLGI-----------------AYISVV-----DKSYFR -YGSGDSTIHYQI---EPTAVEILQ--------IVADI---VNF-DD------LNNV--------------- -----------------------------A--------IVYD-ETFD------------------------- ---------------------------IQ--NTPRRILTNV-----------------------PAQHLYVR MS----------------------SD-PTET-----------KRQVEMLKRIEIKN---------------- --------IFI-------IGN--SRKAP-------------------------------------------- -----------------------DFL-----------EVA------------N------VIS---------- ----DEFDVNWFFL----------------------------------------------TKV--------- ----------------------------------------------------NIAIQILW------------ -----------------YGVLME----FPVLI---------------------------------------- -------------SELLVY----DSVQFRV------------------AVLTFQYFVILHI-H--------- ----D------------------------------------------------------------------- ----------LKSKLSQLVHY---------------------------LTPIS------------------- --TFSEEGVYGPL--V-----------------------------EENDITRYK------------------ -------------------FTLLINQLTFKS-------------------------------------GNNI NNREVGNW--------------------------------------------------TEAGEDGRR----- --------------------------------------------LVLK------------------------ ----------------------------PGITSL------------------------TKS----------- ----------NKKKL-YRVVTVA------------------------------------------------- ---------------------------------------------------------NMPP--------FVY ------------------------------------------K-----K----------------------- ---------VSGNT-T-------------NT--------------------------NDMYDGYC-I----- ------------ELLKRISY-L----------------------L----D----------F----------- ------------D----YILYD-SPD---------GM-YGS------------------------------- -----------------------------MDDDG---------------N---W------------------ NG------------------------AIK---EL--------------ID-K--------------K---AD IAVG-----------------------------------------------------------PISVM---- -AER---ENV--V-----------DF-T-VPY----YDLVG---LTI-------------L-MKK------- --------------------------------PEF-DY--TLGK-------------FLTV---LD------ ----------------------------------EDV--W-FCI-IGA-------FF-L---FS-----ILI CVFDKL------------------------------------------------------------------ --------------------SPFS-YQN-------------------------------------------- -----N------------------------------TVDW-----------------NGEG----------- ------------------------------------------------------------------------ ----------------------------------TEPR-VF------------------------------- ---------------------------------TLKE-----GIWF---CMM--------SLT-----PQG- --------GGET--PRALSGRLVAAT------WWL-----FGFIIIATYTA-----NL-----AA-FLTVSR L--ET-----------------------PIE-----SLDDLSKQF----------------------KVK-- -----------YAPMN---------GSNAL---------------IYF----K------------------- -------------RMQEIEHRFYGIWKNMSLDDNLGAVERAKLAVWDYPV-SD--------KYTKL------ -WETMLES---EF----------------------------------------------PSNKDE--A---- VERVLT-----------G-------E-F-A-YIGDATVNKY--------------------AKLTNCD---- -----LWEVGEE-FSR-KP-------------------------------------------------YALA VQEG-S-P-------------------------LRSQLSTI-----------ILQLINQRELEE-------- ---Y---------------KTKWW-------------KK-------------D--KRDCPDIEDE------- ------------------------SNGISIKNIGGVFLVIV-------------IGSAL-ALI----TLAIE CY---------------------------------WY-KY-------K-PKQK------------------- ------------------------------------------------------------------------ ------------------------------------KKLY-VISSKA------------------------N LNKLDTAPS--------------------------------------------------------------- -----------------------------------------------------GNNLSNLANGY-QSST--- -----QLCNGHVPEGE-------------------------------------------------------- ----------------------------------------------TTS---NGKIE--------------- ---------------------------------------------------NDGHTNTGF------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >NvitIR21a/1-683 ------------------------------------------------------MRFLV------------- -----------------------------------------------------SWSFLVLLQLTVSL----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------NQRHFR----------------KLSKSHE---------- -----------------ARTESLTI--------LLRTIAN-------------------------------- ---------------------DYFSNCTLN--------VIYD-SAYELI----------------------- -------------------YPINFSLYFK--DNSLPIIQETVDFSS-------------------------- ---------------------------GGRV--------------------REKIVEKC------------- ------TNYFV------FLGD--LQAIK-------------------------------------------- -----------------------YIV----------EQDT------------KSKI--VIIST-E------- --------TPWEVK---------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------DFLKSH--------LS---------------------------- ---------KNYLNLLIMA----------------------------------------------------- ----YS------------------------------------------------------------------ --------ASSRNDGSYL------------------------------------------------------ ------------------------------------------------------------------------ -----------------------LYTHKLYA-----------------------------------EGSGST QPMLLSSW---------------------------------------------------------------- ------------------------------------------INNNLTIR---------------------- --------DVN----------------------------L------FPEK-------LTKG----------- ----------FMGHR-LLVSAAE------------------------------------------------- ---------------------------------------------------------N-PP--------FTI --------------------------------------KKSLW----------------------------- ------------------------------------------------------GSDDSNWDGIE-I----- ------------RLLKLSAK-Y----------------------L----N----------F----------- ------------T----IEFTD-ART---------SAY-SP----I-------------------------- --------------------------------DA-------------------------------------- --------------------------VKR---DV--------------LL-G--------------L---TS AAVG-----------------------------------------------------------GIYLT---- -QEL--SESF--------------DA-T-LP-----HAEDC---AAFIS-----------LASTA------- -------------------------------IPK--------YR------------AILGP---FQ------ ----------------------------------LSV--W-LLL-CAAY------FV-LIIPLSFNSNYTIL SLFKHP------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------S--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------GLNN-----MFWF---VFS--------TYTN-SFVVEN- --------PLLNYGIAKNSITILLGI------YWI-----FTIIVTACYTG-----SI-----VA-FITLPV Y--PS-----------------------AIE-----SAAEFLAYRYR------------------IGTLD-- -------------------------HNGWE---------------NWFN--VN------------------- -------------T----------------------------------TD-DP--------LLQSL------ ----------------FRKM-------------------------------------EYLPTLLE--G---- VHNASRAY----FW-----------P-Y-A-FLASKTSLEYIIQTDFAP-----------TWTTKRTL---- -----MHVSDEC-FVR------------------------------------------YN--------VVQL FPAK-S-L-------------------------YTKSMNGF-----------VARVTETGLLDKIINDIE-- ---WEM-------------QRVAM------------------------------MTKKQITK-SISKKIKV- -----------------------EDRELTVEDTQGMFLILG-------------SGFLM-AML----ALALE SL---------------------------------YSYFK-------K-RNI-------------------- ----------------------------KKDS---------------------------------------- ------------------------------------VSEMEGTDWMTESQV--------------------- ------------------------------------------------------------------------ -------------------------MGSWIYG-----K---------------------------------- ---------DAFPGMRQR------------------------------------------------------ ----------------------------------------------------PARGSV-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >NvitIR68a/1-699 ------------------------------------------------------------------------ ---------------------------------------------------------MYFLIVLIICLGTSL S----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------VT------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------DNRRLIY---------------------------------- -----------PA--SNKQLQTLVKL-------LIEEVAE-------------------------------- -----------------------NSRC-IV--------SMVD-TYYR------------------------- --------------------RKVDISQIK--ANKF------------------------------LPTYRV- -----------------------LIRENEEFSPPRR----RLLRILKESK-----HLGC------------- ------DVYLI------MMAN--GLQVA-------------------------------------------- -----------------------SLL-----------RYA------------EEE---RLMN---------- -----VQ-GKFLFV------------------------------------------YDFRIFHVEML----- ----------------------------------------------------------------------Y- ------------------------------L------------W---------------------------- ---------NRIINVIFIR----------------------------------------------------- --------------------------------RYVEF----------------------------------- ------------------------------------------------------------------------ ---------------------------------------------KRRSSNRQLQ----------------- -----------------KYEWYDLNTIPF-----------------------------------PARKKGLI VTRYIDTW---------------------------------------------------------------- ------------------------------------------------------------------------ --------Y-----------------QNRFRYGI---N-H------FTAK--------TDD----------- ----------LRRQK-LQVAVFE------------------------------------------------- ---------------------------------------------------------H-VP----------- ---------------------------------------AVTE-----DAQAYY------------------ --------KSQKDVGSNS----------K-------------------------------PLGIE-F----- ------------EMILIIAN-A----------------------L----N----------F----------- ------------K----PYFYQ-PDNI---QT---ER-WGD------------------------------- -----------------------------SKNDT-----------------------------Y-------- TG------------------------LFG---EA--------------KE-G--------------K---AV FYLG-----------------------------------------------------------DLHYT---- -SRH---IQI--L-----------DL-S-WP-----YNTEC---LTF-------------L----------- -------------------------------TLES-LT-ENSWK------------LLILP---FR------ ----------------------------------LNT--W-LAV-LFT-------LV-F---AC-----ATS FVFSRF------------------------------------------------------------------ ----------------------YMRHVNV------------------------------------------- ----------------------------GENNDSDARKVF-------------------SKSKTMKV----- ------------------------------------------------------------------------ -------------LEKR------------PVQAEEWKG-LYLFT------------DPQ------------- ------------------------------------N-----SVLY---TYS--------MLL-----QVS- --------L-PSL-PRAWSLRVFIGW------WWI-----FSILIAVTYRA-----SM-----TA-TLANAI D--RV-----------------------TID-----TIPELGKSNVA-VG---------------------- -------------------------SWNDE-------------TREFF----I------------------- -------------N----------------------------------SS-DP--------YLQKL------ ----------------SRRY-------------------------------------VVTKDEQS--A---- LAAVA----------N-G-------T-L-C-YYENVYVLQRERVKRQIL---EDELQKNGSQGKHKFQ---- --DHNLHIMEEC-VVN-MP-------------------------------------------------ISLG MDKH-S-P-------------------------LKHHVDKL-----------VKRIIEAGFVEK-------- ---W---------------LSDIT-------------QQSKIL----------------------------- ---------------ELRGEGIADKALIDLDKLQGAVVALG-------------IGYLF-SLL----ALAAE TW---------------------------------HW----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----RYIVMRHPNFNKY------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >NvitIR75u.1/1-625 ----------------------------------------------------------MW------------ -----------------------------------------------------RFCALIF------------ ------------------------------------------------------------------------ ---ISLG----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------IL----VDC------------------------------------------------ ------------------------------------------------------------------------ -----------------------------HEIDELISNLV-------------------------------- ------------------AEA---SA-----GLFFPAAA--VENAVE------FSKILSKNH---------- --------------------------------------VL-N-NQLNY---DDFEEN--------------- -------IVQYP----------VHQTTI-----------------------------------------FLD YD--------------------------------------------------------CPRA---------- ------SE-AL------------RK-AN--------------------NS---------------------- -----------------------GLF----------SA---------------P------------------ --------IKWLILQD---LR-----------------------N---------------APNENCT----- ------------------------------------------------------------------------ --ETDCILN--------------------IFHDY-------------------------------------- ----AMF--PD-SEILIFE----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------RTSK--------------------- --------NY-----------VK--ILSVYRPSPVRD----MMI---------------------------- --EDRGFW--------------------------------------------------SKEDG--------- --------------------------------------------LKMKDA---------------------- -----------------------------H---V------------------SS--RRRRN----------- ----------LYMTP-LKSSIV-------------------------------------------------- -----------------V---------------------------------------T-NP-------DTL- ---------------------------------------NHL------------------------------ ------------TDYR--------------------------------------DEHVDTITKCN-Y----- ------------VWLHHLVA-A----------------------M----N----------A----------- ------------T----VTYNV------------VNS-WGYRD----------------------------- -------------------------------KNG---------------S---W------------------ NG------------------------MMG---ML--------------SR-K--------------E---ID IGGT-----------------------------------------------------------SMFLV---- -GDR---WAD--A-----------HY-IPLS-----TPTR----AAF-------------I-FRQ------- --------------------------------PPLSFV-SN---------------LFTLP---FR------ ----------------------------------PSV--W-IAI-GIL-------LI-I---IF-----LSL VISTKWEWV--------------------------------------------------------------- -------------------------TKEV------------------------------------------- ---------------DSSGT-----------------------------------------P---------- ------------------------------------------------------------------------ -----------------------------------PPS---------------------------------- ----------------------------------LSD-----NLLL---VVG--------AIA-----QQG- ---------FGRN-PRTVPSRIVLLM------LLL-----AALNLYASYSA-----NI-----VA-LLQSTT ---T------------------------SIQ-----TLRDLLDSPIK------------------------- -----------CGAQ----------DIVYNR--------------YYF----N------------------- -------------L----------------------------------EK-DP--------VRRGI------ -IDH-KIE----PKGGK----------------------------------------SNWMSADD--G---- IKNIR----------Q-G-------F-F-A-FFMETGPGYKIIQETFEE--------------DEKCGFRE- -----MYFIE---HFD----------------------------------------------------PMFT IVKQ-S-P-------------------------YVEIMRV-----------NSLKIEESGLKSR-------E MSKFYT-------------------------------KRP-----------------PCN------------ --------------------GLSKFISVGLNECYFAFYTMG-------------YGALI-AFV----VLFAE FA---------------------------------W-----------M-KRIH------------------- ------------------------------------------------------------------------ -------------------------------------CHRE------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------FTCK--- ------QETE--PA---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >OQR71097.1/1-852 hypothetical protein BIW11_01565 [Tropilaelaps mercedesae] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------MENP-------CRGNQS------------------------RVNPE---- ------SESNINLNLLV--IALDCDDTYKAMDVQMKK-FPTSMLIALNR----------------------- --------------------------------------------------------------------PYCP RF-------------------DADDQQVANKKPFALSI-----------------PVTQGPT---------- ---------------------DVLP--------ILADFRA-MLPLSR------WSEIT-------------- --------------------------------------IIVP-YSY-------------------------- -----------------------TEEYLE--QI----MRAVEGVRSND-------EVNS-----AASIAFWE YCPPSALADGNCG------------LNSESM-----------KRILDSYR-NNDNKKVD------------- ------REFII-------IGD--EELVL-------------------------------------------- -----------------------DFF-----------ERG------------VDY---GIFT---------- -----LF-REFFII----------------------------------------------LTT--PY----- ------------------------------------------------------------------------ ----SDTIKDL---------------IFEKI----------------------------------------- ---------ASFANIVIAS-----TDVKDE--DCPVSGT-----------CHIDL-PMNAY-M--------- ----NAV----NKNPDLFERNVD------------------------------------------------- ----------KFNHKYTIKKA---------------------------VLTEL------------------- -----------------------------------------------RESKSCG------------------ -----------------FCSKYTIRT-------------------------------------LTVKAG-RK TFDPVAVW-----------------------------------------------------DYFDG------ --------------------------------------------LQMVED-TSRVSYQ-------------- ---------------------------------------L------FPRF--------LGN----------- ----------MGGVN-LRIGVIN------------------------------------------------- ---------------------------------------------------------E-PP--------MT- ------------------------------------------E----------------------------- -----------VTS-K------------EGRV--------------------------ISVNGTL-V----- ------------DLLKELAR-T----------------------L----N----------F----------- ------------T----YTFIM-PPE---------PV-PGL------------------------------- -----------------------------KQNDG---------------R---W------------------ SG------------------------LIG---QL--------------VR-Q--------------E---TD LALY-----------------------------------------------------------DFTPT---- -PDR---QSA--V-----------NF-T-VA-----FDEAP---YKF-------------L-VPK------- --------------------------------PQP--N--YKY-------------LFLDP---FT------ ----------------------------------WDT--W-LAV-LGT-------VL-I---IG-----PIL WCVHIN------------------------------------------------------------------ --------------------SKFY-D---------------------------------------------- ---------------------------------------Y-----------------YDMR----------- ------------------------------------------------------------------------ ----------------------------------DGKG-LF------------------------------- ---------------------------------KLSN-----CEWY---CFG--------AII-----QQG- --------G-IHL-PDAISGRILVGF------WWL-----FVIVTLTTYSG-----NL-----VA-DLTFPK I--RN-----------------------PFD-----TVDSLL--N---------------------SHMS-- -----------WGAFK---------GQAVI---------------EIL----K------------------- -------------L----------------------------------QQ-QG--------PLTKL------ -SMKLTHI---ETA-----------------------------------------------HEGW--A---- LKEVA----------D-G-------N-M-A-LIGSEVTLYHYIGKQFIA--------------TGQCD---- -----YAVAKEE-IIR-EI-------------------------------------------------KVLA VRPG-F-P-------------------------FLARFNTL-----------LTRMVETGLVIR-------- ---W---------------KKKYW-------------PK-------------E---NECTVESKPQA----- ----------------------GDIRRITIAHMEGSFWVLG-------------AGFLI-SFL----LLGVE LL---------------------------------------------------------------------- ---------------------R-------------------------------------------------- -------------------------------------KRRELRDPQAGK----------------------- RISPTDI----------KENLFRKTGHSDK-----------SHYKTDYGAHGSGAGP--------------- --------------------------------------------------GGKGGQTG-YS----------- ------FDLSNTPFRG---------------------------YS--------------------------- -------------GFP-------------------------------------------------------- --------------------------------------------------NRTDLIP--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------YNYPARRY------------------------- >PargIR1091/1-612 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------ALLTPP--------VV---------------------------- ---------PVEA----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------SAQP-------------------- ----------------------RLVPVYA---------W---------------------------TPPPPE FAITTNSW--------------------------------------------------Y------------- ------------------------------------------------------------------------ ------------------------------TGRL---R-A------LSTH-E------QYQ----------- ----------LHGSH-LFVATLR------------------------------------------------- ---------------------------------------------------------G-EP--------FIK -----------------------------------------PL----------------------------- ---------------NTTSNDSNRAVGERGQTSS----------PPPPLPAHITCQQPRAFTGFL-V----- ------------DMLDVLKS-Y----------------------M----N----------F----------- ------------T----YTLYE-VCD---------NS-YGS------------------------------- -----------------------------LK-DG---------------R---W------------------ TG------------------------VVG---EV--------------MY-A--------------H---AH IGLA-----------------------------------------------------------NLGAN---- -YAR---SHA--V-----------SFPK-VS-----TIYGG---AGI-------------I-MKR------- --------------------------------PRT-TI-KDLLA------------VYFYP---FS------ ----------------------------------VNV--W-VCM-MVS-------IP-V---AA-----IAM YCATRP------------------------------------------------------------------ --------------------RRRL-RQL-LNRCPA---VLWPRRHTPTVRTTTRGRTPIRITITRPSAGSTS SQEPRRKLP------SSKSP-----------LSSTPTQRH-----------------QQEN---SPG----- ----------------------------YG------------------------------------------ -----------G-EDKAPDGNNEA--GVLNLNTKEKED-VAQ------------------------------ ---------------------------------SFFS-----GVWF---AST--------VLM-----QQG- --------Q-EVV-PETGPARLVFGT------MWV-----AAVVLYAAYTS-----NL-----VS-YFTVTK M--SL-----------------------PFT-----DLEGLVKSD---YK---------------------- -----------FGTRQ---------GSVYL---------------DNM----M------------------- -------------T----------------------------------SN-TD--------VFKAA-GSKLE SFGESVQ----------------------------------------------------MPSYED--A---- IKRTL----------Q-G-------S-Y-A-FIGDYVVLDYYQKKD--------------------CD---- -----LVLLKQQ-LFE-TM-------------------------------------------------SSFV LPRH-S-P-------------------------ILPAVNYY-----------MSRMNEGGILEK-------- ---L---------------RQRWW-------------SA------HP-----------CPDAATVTA----- ------------------------YQSIGLSEVCSAVLIMA-------------VGIVL-AVL----VSCIE HL---------------------------------RL-RL-------L-RDARHD----------------- ------------------------------------------------------------------------ -----------------------------------DTKDRTTPSSYSYDN---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------AKKTTPLQI-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PargIR1092/1-583 -----ATSGVQCWPPA---------------------------------RPARTMQSSG------------- ----------------------------------------------------------LVLWLVAVACACEP ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------CLASTSGS------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------G------------------------- --------------------HQRPRNTLL--SLVQAAQ-----------------------HHHPPPAA--- ---------------------------HHPPQ---------LSPLPENA----------------------- ------------------------------------------------------------------------ -------------------------F----------LEYSR----------LYRR----------------- --------HH-------------------------------------------------------------- ------------------------------------------------------------------------ -----VAP--------------------DVAPGP--------LI---------------------------- ---------TV------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------SEQQQQQQ------------------ -------------------EEEEKEEPRR---------Q---------------------------EEEVTY ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------FP---N-L------NIAT-R------RLD----------- ----------LTGLH-IRCLTES------------------------------------------------- ---------------------------------------------------------W-QP--------FTN -----------------------------------------NK----------------------------- ---------------P-------------------------------------VKGGGVSIGGFM-G----- ------------ETFQLMSA-F----------------------L----N----------F----------- ------------T----YDCRS-APD---------GQ-FGD------------------------------- -----------------------------YE-DG---------------K---W------------------ TG------------------------LVG---EL--------------VA-G--------------R---GD VIVT-----------------------------------------------------------ALDST---- -YHR---SQV--I-----------DF-C-FP-----SGDIE---YAM-------------I-IRT------- --------------------------------PEA-----DPWS------------NFTRQ---LQ------ ----------------------------------PAT--W-LAC-LAF-------VV-L---AP-----ILY FFLASR------------------------------------------------------------------ --------------------S--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------PFLV--TL------------------------------ ---------------------------------SLQD-----SWFT----IQ--------TLL-----LNQ- --------G-NLC-VKGMARRVFFLT------VVM-----TTWLIITFYTS-----VL-----VS-YLTVPL I--TP-----------------------PFT-----DMAGLLKKGT--HS---------------------- -----------LGLQR---------GNSEV---------------ERL----R------------------- -------------T----------------------------------SQ-DP--------MLQKV------ -WSKIVVK---DP------A-------------------------------------NLVPTSEE--G---- LQKVL----------E-E-------K-F-V-FLMEKNYYQFHMGGD--------------------CT---- -----TTTLREK-VFT-FG-------------------------------------------------AGMA VQKD-S-P-------------------------LRLVFSHH-----------TLVQHVSGIVDR-------- ---S---------------RRRHR-------------PAMPS----------------CVTRAVE------- --------------------------ALGLPPLVTVFIVLV-------------VAIPL-AGL----FLLLE WV---------------------------------VS-RS-------F-HRHSGG----------------- ------------------------------------------------------------------------ -----------------------------------KSPNKRDPHKR-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------QQQQPSLP------HA-LWGRP------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------VKQFLDLVKSPR------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PargIR1093/1-676 ------------------------------------------------------MGACG------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------FPLPGVVSPHHHLH----------------GV------------------- ---------------------------------HRRPSSLEANREPL------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------SPDERGVTVFNMRTSFAF--WGLVLG-----LLLSPFITVSAAADGT----- ---------------DCPCLSQIIYD---------------IVTTNK------WSSVT-------------- --------------------------------------FVYD-GNQD--LLHP------------------- -------------------RCLRGSGLLP--RLWAA------------------------------------ ------------------------------------------RVTVSAHRYHPSREQE-------------- -------SFVL------------------------------------------------------------- ----------VYNNA------TMAFL-----------DKA------------SDER--VLDT---------- --------TNWLLL---------------------------------------------LLEEGEEG----- ------------------------------------------------------------------------ ---------------------------LPAL----------------------------------------- ---------LHHAQLLNLF---IDSNF-----------------------------LVASY----------- -------------------------------------------------------------NSCYA------ -E----------------------------------------------VRSVYRV----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------GPKTGP LVESIGVW--------------------------------------------------NRTLGYQVT----- ---------------------------------------------------LDGSTYER------------- ----------------------------------------------------------RHD----------- ----------FQGYP-LQGIGVE-------------------------------VFD--------------- ------FFTTY------------------------------------------------LP----------- ------------------------------------------------------------------------ ---------------D-------------GHL-----------------------------SGFV-G----- ------------DIVTILKA-S----------------------H----N----------F----------S L-----------S----YKTLE-------------GYAYGK----L-------------------------- -----------------------------VSEKT---------------N--VW------------------ TG------------------------MVG---EL--------------QF-G--------------R---AD LTVS-----------------------------------------------------------ELSIT---- -KER---SEV--I-----------TY-T-QP-------------------LY--------IISRKLF----- ---------------------------VST--TEDFQK--KLL-------------AYATP---ME------ ----------------------------------TVL--Y-VCI-LAA-------MT-A---LI-----LVL YFTERL------------------------------------------------------------------ -----------------------------------------------------------RL----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------LFL---PTK-------EEPV------------- ---------------------------------SLSV-----ASWY---MLS--------ALL-----QQG- --------C-STC-PTSTAGRIVFWL------AFF-----MSVIVYASYSA-----TL-----VS-HLTVER PT-AL-----------------------PFS-----DLSQLSRQSDW-DAGVN------------------- -------------------------------------------RNDLF----Q------------------- -------------VIASQT------------------------CLGSVTE-ECR-------VLQDV------ -WNKVVMR---SP------D-------------------------------------NIVTSYKD--G---- LRKVL----------N-G-------Q-Y-V-FIGVDVTTRYYI---------------RGMPPEDACR---- -----IKELPGR-YIT------------------------------------------GG--------IAIG LQHE-S-P-------------------------FRRIFDLS-----------LQRLREMGVMNK-------- ---M---------------ILKWL----------------------------S-GRGYCHLQTTISA----- ----------------------------KLADVAALFILLM-------------AGLGT-SLL----LLIAE LL---------------------------------VA----------------------------------- ------------------------------------------------------------------------ --------------------------------YLYRITRQKCFR---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PargIR1094/1-412 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------G---EL--------------AQ-G--------------L---AD VIVA-----------------------------------------------------------PLDHT---- -QAR---STV--V-----------DF-C-MG-----LRISG---YHL-------------I-MRR------- --------------------------------STT-N--DSMWT------------SFTRE---FQ------ ----------------------------------WQV--W-L-V-VGV-------CL-L---LG-----SFV FYATGF------------------------------------------------------------------ --------------------S--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------PVER-ETI------------------------------ ---------------------------------TLGD-----AFLM---TYG--------SLC-----AQS- --------T-SLA-LTSTSARIAFIT------IYL-----NTMLLYAFYTC-----FI-----IS-HLAIKP C--GR-----------------------PFD-----TMQEMFDQGHN-YR---------------------- -----------LGFVK---------GISVE---------------ESF----K------------------- -------------L----------------------------------AS-GG--------LYQDV------ -WKQLVEP---HY------N-------------------------------------SLVRTDEQ--G---- ITRAL----------Q-D------PR-Y-V-HFMAENKFLFKYAHN--------------------CD---- -----LVKIPHR-YME-IA-------------------------------------------------STFA VPKG-S-P-------------------------LRRIFTYH-----------MMRLRDTGIIHR-------- ---H---------------WRRWR-------------PRDSV----------------CDTVDSL------- -------------------------QAFTLYNLLTVFLMLG-------------TLAGL-ATV----MLGCE RV---------------------------------V--AM-------W-ERTSLV----------------- ------------------------------------------------------------------------ -----------------------------------TTVETNTSWTRLHHQLTR------------------- ----------------MTLHVF-------------------------------------------------- ---------------------------------------------------KVQTTVTTTLVRA-------- ------LNQREAPTPTTNDSDDNY-TAGNT------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------SSEP-EGVT-ALADREH------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PargIR21a/1-846 -----------VLQRPDQDL--------PCHTPPTSPASATPRSLPAPTPRAGAMRESPC------------ -------------------------------------------------SSL-SCALACLLMVVA------- -------------------------------------------------------------------TPAPR SFTHS------------------------------------------------------------------- ------------------------------------------------------------------------ -------------------QSSASPI---------------------------------------------- ---------SSTDPLLS--VSSPG----------------PALLGPAGQDPTPPAVVVSTSPPHAPRNPHPR SQKGEPRRTRNATSFSTKARARRSSSPQRLSRPSISTPEHSAVKAAAAAAAAGAPGSPSDDFGSEKLPGEHL GAGSVLAEDR----SEDRSRDDFDRAAREEGVLRQVAS---------------------------------- ----------------------LLM--------AVRGEQV-------------------------------- ------------------------GRCAAT--------ITSD-QFYL------------------------- --------------------PAVDYSLT---------------------YLAAMNEEQPGSQEQVSPAALFT LPPPP-------------------YQDGEAL------------SSLVAGY-RSLRRETC------------- ------AHYIF------LVSD--SSGLL-------------------------------------------- -----------------------RLL-----------RSL------------NEE---SIDL---------- ----LAE-T--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------VLVTH--------LL---------------------------- ---------RQQDLLRFLQTPPVSK----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------MVKVLLV----------------- ---------------------------------------------TPSAARGE------------------- -----------------EA-RLLLHTHLFFQ-----------------------------------DQ-ERI SLKRLGTW--------------------------------------------------PPARPASPA----- ---------------------------------------------------E-------------------- ------------------------------RPGL---Q-W------FPEK--------LKD----------- ----------FHGFK-LRATTFN------------------------------------------------- ----------H------------------------------------------------PP--------VSI -----------------------------------------FE----------------------------- -----------PQP-----------------------------------------DGSVSYDGLE-I----- ------------RLLRTLAF-A----------------------L----N----------F----------- ------------T----AEIGR-PRDG--------EK-WGR------------------------------- -----------------------------RLANG---------------S---W------------------ TG------------------------AVG---ET--------------VR-G--------------E---AD VSFA-----------------------------------------------------------NYFIT---- -ADR---LRI--M-----------DM-T-RP-----HYIDY---TCF-------------I-TPK------- --------------------------------PKP-LP--QYT-------------AVAWP---FH------ ----------------------------------VWV--W-SAV-VAT-------LV-V---VP-----PVV RAAGEA------------------------------------------------------------------ -------------------ET--G------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------TH---WFR------------------------------ ---------------------------------RLDN-----SFWY---VWG--------VFLT---RSQP- --------T-RLV-PSSSGLRVVVIG------SWV-----AAMIISVAYKS-----SL-----IA-FLLVPL P--AQ-----------------------PVN-----TLEQLL-----------------------ESGLG-- -----------WGVRD---------RGGWD---------------EWF----S------------------- -------------N----------------------------------SL-DP--------TSQKI------ -AAGFQ----------------------------------------------------FVEGIDG--G---- LAKVL----------E-G-------D-F-A-FMNSGTFLRYLVASNFTNA-------------FGQTG---- -----LHVAKEC-YVP------------------------------------------FR--------IGLG LPRF-S-V-------------------------YTSRFNDV-----------VARVVEAGMVTR-------- ---W---------------FQDLL-------------DK-------------ALQKQRRKARRRQEALQVEP --------------------QYSKTQVLGLYHVQGPFILLL-------------MGWLL-AGA----SFLLE LM---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------T---SRRCRCR------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PargIR25a/1-866 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----MMTMKKGDDIEAT--VNATCDMMDAAIQEN--E-PPHIVL---------------------------- ---------------------------------------------------------------------DAT NTGM--------------------ISETVKSFTKALAL-----------------PTFAASYGQEGDIREWR DLTEEEEKFLVQL---MPPGDIIVQ--------AIRDI---VRT-QN------ITNA--------------- -----------------------------G--------IIYD-DTFV------------------------- ---------------------------ME--HKYKSLLQNL-----------------------PCRHILTM VEA---------------------RE--MDL-----------RKQMKRLKDADIVN---------------- 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--------------------SPYS-YQN-------------------------------------------- -----N------------------------------KERY-----------------KDD------------ ------------------------------------------------------------------------ ----------------------------------DEKR-EF------------------------------- ---------------------------------TFKE-----CLWF---CMT--------SLT-----PQG- --------GGEA--PKNLSGRLVAAT------WWL-----FGFIIIASYTA-----NL-----AA-FLTVSR L--DT-----------------------PIE-----SLDDLSNQY----------------------KVQ-- -----------YAPMN---------GSSTM---------------TYF----E------------------- -------------RMAYIEKKFYEIWKDMSLNDSMSDVERAKLAVWDYPV-SD--------KYTKM------ -WQSMQEA---GL----------------------------------------------PQTFES--A---- LERVRKSTSS-----S-E-------G-F-A-YLGDATDIRY--------------------QVLTNCD---- -----LQIVGEE-FSR-KP-------------------------------------------------YAIA VQQG-S-P-------------------------LKDQFNDA-----------ILKLLNQRKLET-------- ---L---------------KERWW-------------NQ-------------NPEKKVCEKDDDQ------- ------------------------SDGISIENIGGVFIVIF-------------VGIGL-ACV----TLAFE YW---------------------------------WY-KH-------R-KGP-------------------- ------------------------------------------------------------------------ ------------------------------------RVTD-SAKVLA------------------------V RE---------------------------------------------------------------------- ------------------------------------------------------------------------ -----------YPTN--------------------------------------------------------- ----------------------------------------------DVD---KSNFTT-------------- ---------------------------------------------------DKSNFNTEYTTGGDG------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------YDIA----------------------PVANPW-------------------------------- >PargIR40a-1/1-397 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------MVG---MV--------------AR-Q--------------E---AH LAID-----------------------------------------------------------EITIT---- -AAR---ARV--V-----------DF-T-RP-----YYTES---SAC-------------V-SRA------- --------------------------------PRE-TN--RAF-------------AVLSP---FT------ ----------------------------------TQV--W-III-SLS-------VI-G---IG-----LVL FLL--------------------------------------------------------------------- ---------------------SFL-IGQ-------------------------------------------- ---------------------------------------Y-----------------L--E----------- ------------------------------------------------------------------------ ----------------------------------V------------------------------------- ----------------------------SVSF-SLHD-----LTFN---TYR--------SLV-----IQG- --------N-RLP-TEQSPLRCVLLA------WYL-----YCYYIYAVYAG-----RL-----TA-VLAIPV F--EK-----------------------PID-----TLLDVLDASRH-------------------GLYP-- -----------VVIRE---------SSVDF----------------MF----Q------------------- -------------M----------------------------------AA-SG--------IYNDV------ -GRLI-----------TDDN-------------------------------------NYVDAPPR--G---- VASVL----------K-G-------E-A-A-YIDARLSSEIQT----II--------------QGRDN---- -----FFIGRQS-FFP-QS-------------------------------------------------YGIA CSKG-A-P-------------------------YRAIFDQV-----------LERIVEAGLVDK-------- ---W---------------KKDEI-------------IK-------------L---GQAASLSGRLDQA--- -------------------RRGAGPGAITIKHLQGAFFMYV-------------LGSGV-ACL----AFLME KK---------------------------------VY-RF-------T------------------------ ---------------------------IIKDF---------------------------------------- ---------------------------------YVGSDQRQKWRSKNVKDTAR------------------- -------------------------------------N-----------RGGRP------------------ -------------------------------------------------------------------TD--- -----GEERSVGPARQHPLEVM-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PargIR40a-2/1-375 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------EG-------------------------- --------------------PGDAP-L-----------DGW------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------L------FQDL-DHL----YQD----------- ----------FKGRQ-LVAAVLD------------------------------------------------- ---------NW-------------------------------------------------P--------FFG -----------------------------------------LR-----F----------------------- ------------LP-D-------------G--------------------------GAVADSGLD-V----- ------------SVLNALSG-S----------------------L----N----------F----------- ------------T----YIVKE-PSD---------GQ-WGG------------------------------- -----------------------------PQPDG---------------A---I------------------ TG------------------------IIG---MV--------------AS-H--------------Q---AH LAIN-----------------------------------------------------------EITIT---- -ASR---ERV--V-----------DF-T-LP-----YFLES---TIL-------------V-SRA------- --------------------------------PAP-KS--KAF-------------AIFYP---FS------ ----------------------------------PLI--W-GLL-AAS-------TA-L---MG-----PIV WVV--------------------------------------------------------------------- ---------------------ATA-LRS-------------------------------------------- ---------------------------------------A-----------------AGHK----------- ------------------------------------------------------------------------ ----------------------------------DKL-------EPYGLK-----ATVL------------- ------------------------------HL-SLQE-----SAFN---MYG--------SLL-----RQE- --------N-MIQ-VNRWSLRILFFL------WYI-----FCYIIYAIYSG-----TL-----TA-YLAIPS F--EQ-----------------------PID-----SLTDLLEATRD-------------------GYVP-- -----------LFLVG---------SSNEF----------------LF----K------------------- -------------V----------------------------------AS-SG--------IFHQV------ -WKAH-----------DPSA-------------------------------------SFSYTIDD--A---- MDMVL----------K-G-------K-R-V-FVNARLGSLIRA----TI--------------RGRHK---- -----FYLARQT-MYS-QG-------------------------------------------------YAIV CRSG-A-P-------------------------YKRNFEKM------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PargIR40a-3/1-618 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------GR----------QVY-------------- --------------------------------------LLHD-LSS-------------------------- --------------------SVASS-AMV--TS----YQRLGQ------------------------LIIVR Y--------------------------TSEL-----------EEMEATVR-SHLDVLTL------------- 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---------------------AWL-RQC-------------------------------------------- ---------------------------------------Y-----------------I-QE----------- ------------------------------------------------------------------------ ----------------------------------AR------------------------------------ -----------------------------PQH-SIQD-----FAFN---MFR--------SLV-----VQG- --------N-LLL-ACHWEQRIVFFT------WYF-----FCFTVYAMYAG-----TL-----TA-FLAIPA Y--EK-----------------------PID-----SLWDLLHAVKQ------------------KNYKP-- -----------VVVLG---------TSNEF----------------IF----K------------------- -------------E----------------------------------AK-RG--------IYRDL------ -WQVF-----------DDSE-------------------------------------GYVDTHSD--A---- MDKVL----------K-G-------K-Y-V-FLNAQLGAEIRA----VT--------------RGRHK---- -----YYFARNA-FYP-QG-------------------------------------------------YGIA CTSG-S-P-------------------------FRRVFDKL-----------LTQMSAAGLVQK-------- ---W---------------TRDEI-------------MK-------------A---AKRDNDRAT------- -----------------------GPGAITLRHLQAAFFLLV-------------LGYLL-GGL----ALLME RI---------------------------------RH-RR-------Y-ATTLNQVGQTAT----------- ------------------------------------------------------------------------ ---------------------------------EMMKEKFKNREPMGK------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------LPE-SEK---YGD-------------INIEIN----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PargIR40a-4/1-742 -----------------------------------------------------MMF---------------- P----------------------------------------------------QWMLWMLVSTFSLCMRAFS G-------------------TTEKTLSSETD-----------------QQDDLPHTLVRVATP-----TTTP VFT--------------------------------------------------------------------- -------------------DAAPLTNKLD-VERRDFRDYNLLLPYDAGRS----KKDLLWDPLLL------- ---RDHPQVTQPNTADDLMRMVSVPS-------TCSSYLL-------------------------------- -------PLDVPGCPFT--TTNIHHDPREYHDSGRTR--RSLVNTGSG-GSTYC------------------ --------------------------------------------------------------------DNCS LALSL-----------------------AMKADQHLTL-----------------VD--------------- ----------------------LVS--------YLASL---TSGR----------QFY-------------- --------------------------------------LVYD-DVL-------------------------- --------------------PGVEG-VAR--SF----QEALGD------------------------TILIP Y--------------------------DQDI-----------LLLTEALT-SGYHVQAM------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------YRMTR-PPD---------GN-WGG------------------------------- -----------------------------PQPDK---------------T---V------------------ TG------------------------MIG---QV--------------AR-H--------------E---AH VAIC-----------------------------------------------------------SVTVT---- -DIR---ETV--V-----------DF-T-VF-----YFLET---TTL-------------V-SPA------- --------------------------------PKE-KN--RSF-------------AIFST---FT------ ----------------------------------VGV--W-LCI-CLV-------TV-L---VG-----PLL YVV--------------------------------------------------------------------- ---------------------TRL-LVV-------------------------------------------- ---------------------------------------Y-----------------LDKE----------- ------------------------------------------------------------------------ ----------------------------------D------------------------------------- ----------------------------SVQY-SLQS-----FSFN---MYR--------NLM-----VQG- --------N-LIT-SHRWCLRFIFIS------WYF-----FSLYINALYSG-----TL-----TA-AFAVTS Y--AK-----------------------PID-----SLHHLAKAHRD-------------------GYTI-- -----------GAVRD---------SSYED----------------AF----K------------------- -------------S----------------------------------AK-SG--------IYHEV------ -WQLFN--------HEDRDQ-------------------------------------SFLPNPDA--G---- IDKIL----------Q-Q-------K-F-V-LIHAHLNSKVKA----TQ--------------KGREK---- -----FYFARQT-FLY-QG-------------------------------------------------YGIA CNSG-S-P-------------------------IKDVFNRI-----------LIRLTEAGLVTQ-------- ---W---------------ANDEV-------------NK-------------V---ANHNTSP--------- -------------------G-NSGPTAINLKHLQAAFFILV-------------LGFAT-STM----ALGLE IM---------------------------------AS-SW-------W-QSGQATRIIEAA----------- ------------------------------------------------------------------------ -------------------------------------VIRVDDRPKQLTQAT-------------------- --------------------------------------------------EGL------------------- ------------------------------------------------------------------------ -------------------RRSAG-------------MSAFPIQ---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PargIR40a-5/1-486 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------T----- ------------------------------------------------------------------------ ----EELPVL--------------------L----------------------------------------- ---------REGTQVALVQ----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------RLKP--------------------- -------------------DKAQLFSSRV-------------------------------------DPDGQI RFHHVWSW---------------------------------------------------------------- ---------------------------------------------SVEGV-C-TNS---------------- ----------------------------HQVKSE-----L------VPDL-QRL----YYD----------- ----------FQGRQ-LVVTTNN------------------------------------------------- ---------YW-------------------------------------------------P--------YFQ -----------------------------------------IE-----T----------------------- ------------LQ-N-------------G--------------------------TVVPISGID-H----- ------------NVINILSE-K----------------------L----N----------F----------- ------------R----YRLIS-PPD---------GN-WGG------------------------------- -----------------------------PQPDN---------------T---I------------------ TG------------------------MVG---QV--------------AR-H--------------E---AH AAIC-----------------------------------------------------------TLTVT---- -DIR---ETV--V-----------DF-T-VP-----YYYQS---VTL-------------V-SPT------- --------------------------------PKE-KN--RSF-------------AVLSP---FT------ ----------------------------------VRV--W-LCI-ILV-------TV-L---SG-----PLL YLV--------------------------------------------------------------------- ---------------------SRL-LVV-------------------------------------------- ---------------------------------------V-----------------TGKE----------- ------------------------------------------------------------------------ ----------------------------------D------------------------------------- ----------------------------GTQH-SLRN-----LSFN---MYR--------SLM-----FQD- --------N-LIN-THRWTHHFILIG------WYL-----FSLYIHAMYSG-----TL-----TA-ALAITA Y--EK-----------------------PID-----SLYDLAQAHRD-------------------GYTI-- -----------ATTRD---------SSYYA----------------TF----K------------------- -------------S----------------------------------AK-SG--------IYQEV------ -WQLFN--------HKDPHK-------------------------------------SFLPGSEV--G---- IKMIL----------K-K-------R-Y-V-FITSLLTSKVRA----TK--------------MGREN---- -----FYIARQT-FLP-HG-------------------------------------------------NGIA CNTG-S-P-------------------------FRDNFSRI-----------LIRLTESGLVVK-------- ---W---------------ENDEM-------------SK-------------I---SQ-YRSP--------- -------------------KKEFGPTPITLHHLQAAFFIMM-------------LGFVI-STI----FLGAE IM---------------------------------VN-LW-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PargIR40a-6/1-456 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------PDGQI RFHQVGSW---------------------------------------------------------------- ---------------------------------------------SMGGV-C-TSS---------------- ----------------------------HQVKGG-----L------VPEL-QQL----YTD----------- 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---------------------SRL-LVV-------------------------------------------- ---------------------------------------C-----------------TGEE----------- ------------------------------------------------------------------------ ----------------------------------N------------------------------------- ----------------------------GTQY-SLLI-----LSFS---MFR--------SLV-----FQD- --------S-LMN-TPRWSLRFICFG------WYL-----FSFYIYAMYSG-----TL-----TA-ALAIIA Y--EK-----------------------PID-----SLYDLAQARRD-------------------GYTI-- -----------ATTRD---------SNYDA----------------AF----K------------------- -------------N----------------------------------AE-SG--------IYQEV------ -WQLFD--------HKDPKR-------------------------------------SLLLNPDV--G---- IDLVL----------R-Q-------K-Y-V-FINSLLSTKLKA----AQ--------------RGREK---- -----FYLARQT-FLP-QG-------------------------------------------------YGIV CNSG-S-P-------------------------IKDIFSRI-----------LIRLTEVGLVIK-------- ---W---------------TNDEV-------------NK-------------V---LL-FMSS--------- -------------------GSDAGPTAISLQHLQAAFFIMV-------------LGFTI-AAI----VLVLE IV---------------------------------AN-FW-------S-RG--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PargIR40a-7/1-679 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------R--RSQ--TNADAGRTYC------------------ --------------------------------------------------------------------ENCS LALSL-----------------------ATRADQDLTL-----------------VK--------------- ----------------------LLL--------YLTSL---TSGR----------QFY-------------- --------------------------------------LVYD-DLM-------------------------- --------------------SDVRGAVVR--SV----HEAFGD------------------------TVLLP Y--------------------------DPGF-----------LLLTEVLTLNHHHVQAM------------- ------RHVFV-------LCS--VNHVL-------------------------------------------- -----------------------KLF-----------EQV------------RNK---ALES---------- -----PT-IQWF-V----------------------------------------------IVDRDLT----- ------------------------------------------------------------------------ ----EALQEL--------------------L----------------------------------------- ---------REGTQVALVQ----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------RLAT--------------------- -------------------QGAQLFSSKV-------------------------------------DPDGQL RFHRVGLW---------------------------------------------------------------- ---------------------------------------------SASGG-WPSRE---------------- ----------------------------QQVKEE---D-L------FPDL-HQR----YSD----------- ----------LQGRQ-LVIATKD------------------------------------------------- ---------NS-------------------------------------------------P--------FFK -----------------------------------------VK-----T----------------------- ------------LG-N-------------G--------------------------TVLPVHGID-Y----- ------------SVIDTLSE-T----------------------L----N----------F----------- ------------T----YRLVL-PPD---------GL-WGG------------------------------- -----------------------------PKPDK---------------T---I------------------ TG------------------------LVG---QV--------------AR-H--------------E---AQ ATLC-----------------------------------------------------------ELTIT---- -DLR---ETV--V-----------DF-T-AP-----YFLES---MTL-------------V-SPA------- --------------------------------PQE-MS--RSF-------------AILSP---FT------ ----------------------------------AEV--W-LCI-CLA-------TL-L---AG-----PVF HAM--------------------------------------------------------------------- ---------------------ARL-LPA-------------------------------------------- ---------------------------------------H-----------------LEGE----------- ------------------------------------------------------------------------ ----------------------------------EEE---------------------------------DD DEV------------------------ASSKL-SLQS-----LSFN---AYR--------SLM-----AQG- --------C-LIT-CQRWSLRLILYC------WYL-----FSLYIYAIYSG-----TL-----TA-ALAITA Y--ER-----------------------PID-----SLYELAQARRD-------------------GYTI-- -----------ATLKD---------TNYET----------------TF----R------------------- -------------R----------------------------------AK-TG--------IYHEV------ -WRLFH--------HEDRDK-------------------------------------SFLPSQDY--G---- FDLVQ----------Q-E-------K-Y-V-FIIAQLNSRLKA----TQ--------------RGREQ---- -----FYIARET-FLP-QG-------------------------------------------------YGIA CSSG-S-P-------------------------FRDVFSRI-----------LIRLTEVGLVNK-------- ---W---------------VNVEV-------------NR-------------V---SR-FESS--------- -------------------SKDRGPRAISLQHLQAAFFVMV-------------FGFAV-SSL----ALVVE IM---------------------------------AS-LW-------W-QNDEATPSEE------------- ------------------------------------------------------------------------ ------------------------------------VMVRVEDP----SSTA-------------------- --------------------------------------------------GARQLE---------------- -----------------------------------------------------------------DHL---- ----------------FTKKRAD-------------------VQV--------------------------- ----------------------------Y------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PargIR40a-8/1-498 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------GKTRIPH----------------- ------------------------------------------------------------------------ ------------------------------------------------------KMRYLTPQLFVCIVLVWN RSVGAQDQPFQVHAPEPTTTTASTAT-------T-------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------------T TPVL-------------------------RNMAEDLTL-----------------AD--------------- ----------------------LVS--------YLIGL---TSGQ----------HFY-------------- --------------------------------------LVYD-DVK-------------------------- --------------------PGVAD-VAR--LF----HLRG-D------------------------ITLLP Y--------------------------DPTF-----------HLLAETLR-SYNRVQVT------------- 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---------------------TRL-LVV-------------------------------------------- ---------------------------------------Y-----------------FGEE----------- ------------------------------------------------------------------------ ----------------------------------D------------------------------------- ----------------------------SIHF-SMQS-----LSFN---MYR--------NLM-----VQN- --------N-LIQ-SHHWSLRFIFFC------WYL-----FSFYVYG------------------------- ---EN-----------------------GLY-----SLKDCVQC---------------------------- -----------------------------C----------------SL----K------------------- ------------------------------------------------PK-SQ--------LKY-------- ----LG--------HHFENR-------------------------------------MFLLDIDI------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------DVIVYL------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PargIR68a-put/1-610 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------STQHQRL--------- ----------------SPVMVDVAR--------RLLKEEL-------------------------------- ------------------------AGCSLT--------VIGG-GREA------------------------- --------------------------------------------------------------AEDFTHLAVN MG------------------------VLYQVS----------SGQLSLENPPNITWWGG------------- 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--------------------LPSS------------------------------------------------ ---------------------------------------------------------PDHP----------- ------------------------------------------------------------------------ ---------------------------------------EFH------------------------------ ---------------------------------SWGL-----SFVF---TLG--------A-F-----TCR- --------S-MRL-PATDRLRVASLT------LLF-----MGFVIAITFSG-----NL-----TA-FMTTRS V--EA-----------------------AIR-----TLSELARSHLT-IVGFG------------------- ---------------------------------------------NYW----P------------------- -------------IAFAG------------------------------SE-NP--------SVRSL------ ------------------TD-------------------------------------KYKSVY-D--TLPYF RKAAE----------E-R-------Q-V-A-LIENRNHLEFIQRRRYTTR-------------RGESP---- -----LRIQEEC-LAT------------------------------------------YG--------VGAV LSMH-S-P-------------------------LAPYVDKA-----------IHHMQAGGLTDK-------- ---F---------------FREVL-------------TQ------DL---------DDSHHQQEDGE-ASWL DL-------------HDQILIPSGPQVLTVEHVQGAFIVLA-------------VGYLA-ASL----SLVGE VM---------------------------------MV----------------------------------- ------------------------------------------------------------------------ ---------------------------------ADLGLTA-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PargIR76b/1-655 ------------------------------------------------------------------------ ---------------------------------------------------R-------------------- ------------------------------------------------------------------PRRAPP ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------S------------- ------HLVV------------------------------ASVR---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------MQ--GLVQYVTFN-----VC----------------LGVVG---- -HMQQINFF----------------R---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------TSTDSSSDSTRQYLSKC-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------LA QI---------------------------------------------------------------------- -----------------------------------------------GRQ-EL------------------- -------------------------------------------------N--------TPN----------- 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--------------------RVRL------------------------------------------------ ---------------------------------------C-----------------KGDP----------- ------------------------------------------------------------------------ ----------------------------------TLTR-IF------------------------------- ---------------------------------PFDQ-----CVWF---VYG--------AMM-----KQG- --------S-MLK-PISDSSRILFAT------WWL-----FIMIVTSFYTA-----NL-----TA-FLTFNG L--KL-----------------------PIQ-----KVGDLRA-S---------------------DDLV-- -----------WLAFK---------DGALV---------------EII----S------------------- -------------------------------------------------T-HP--------KLKIL------ -RDLQAEG---RGR--------------------------------------------FVESREE--A---- LSLVR----------T-N-------K-Y-V-YIDDMQVLDHLIQEDFKQ-------------QRRK------ -----KENETCS-FYT-APLLT---------------------------------------DKDFTFWYGYG FKKD-S-Q-------------------------YTELFNGF-----------FRRLSFFGILDF-------- ---L---------------HNNAT-------------SS-------------S---PVCTLPKGF------- -----------------------KDRRLQNKDLLTTYVLGF-------------VGIVS-SFI----VFGCE FA---------------------------------LR-RR-------R-K---------------------- --------------------KR-------------------------------------------------- ------------------------------------TKQAHVGR-------------------------PPS T------------------------------------------------------GT--------------- ----------------------------------------------------RVASLDIQ-NL--DW----- --------SSNLPPLPNNRPRTPF-------------ELRYPQY---------------------------- --------------VRGYDP----------------------RGDR------YGRETG-------------- --QGGRSHPR---HNSQRMENMVLEARRNPFLIPGKINNLSVL---WDQRRSKLILQDLTKLSGNVA----- ------------------------------------------------------------------------ ----------------------------------------YVDGVP-------------------------- ------------------------------------YAVMQYKDKDGLKMQKMIL--------SDLI----- >PargIR8a/1-446 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------N-------------------------------------------- -----------------------TLF-----------SKA------------VRN---NLVT---------- ----RDS--RWTLV----------------------------------------------ATDHKS------ ---DEFDRDMLTESTG--VTLMTPAQEVCCTV-RNRNTNCD---------CDT------------------- ------------------------------L----------------------------------------- -----------MIPRELTV----N--------------------------------AMLML-A--------- ----RVLKAND---------------------------------------------QQNGGGDGG------- -------DQPSTTSFYSALRT---------------------------ELN--------------------- --------SWQNMKW------------------------------EQDTLQMVP------------------ ------------------QFMFDITA------------------------------------------INST DTSAVGSW--------------------------------------------------TTADK--------- ------------------------------------------------------------------------ ---------------------------LRLNPEY------------------------EHS----------- ----------PIRRF-FKIGTIM------------------------------------------------- ---------------------------------------------------------A-RP--------WVS ------------------------------------------------PISGS------------------- ------SVRKKPTS-S-------------NP---------------------------DDYMGYC-V----- ------------ELAARLAE-K----------------------M----K----------F----------- ------------D----FEFKF-PSD---------GQ-YGA------------------------------- -----------------------------RQKNG---------------S---W------------------ NG------------------------LVG---DL--------------SN-G--------------V---TD LIVA-----------------------------------------------------------PLTMT---- -SER---EEV--I-----------DF-V-APY----FDQSG---ISI-------------A-MRK------- --------------------------------RQR-EE--SLFK-------------FMTV---LK------ ----------------------------------AEV--W-VSI-VAA-------LV-V---TG-----IMI WLLDRY------------------------------------------------------------------ --------------------SPYS-AQN-------------------------------------------- -----N------------------------------ADLY-----------------P-------------- ------------------------------------------------------------------------ ----------------------------------PHCR-KF------------------------------- ---------------------------------TLKE-----SFWF---ALT--------SFT-----PQG- --------GGEA--PKALSGRTLVAA------YWL-----FVVLMLATFTA-----NL-----AA-FLTVER M--QS-----------------------SVQ-----SLEALARQA----------------------KIN-- -----------FTTTK---------NSAIY---------------EYF----S------------------- -------------NMAKAEDELFR------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PargIR93a/1-751 ------------------------------------------------------------------------ -----------------------------------MAGHR----RPWACWTL----SI-MTLFTFTAAQ--- ------------------------------------------------------------------LDYQNS ------------------------------------------------------------------------ ----------------------VLGVYME------------------------------------------- -SVMLENRRLQTH------EMIQKAV-------ADGSAAMSL--------------------GTLSVEFLSS --MND-SMPE-DMSVML--TMASCSSTHMWAPGLAEK---GILQIAITE----------------------- --------------------------------------------------------------------AGCP R----------------------------ITHSTAITV-----------------PLAS-GS---------- --------------------RDLVQ--------VFRDLR--TRNTLS------WRDIT-------------- --------------------------------------VIHD-DSI-------------------------- -----------------------DQLDMK--DIVNLLAEGTSKDP-------------------HTSITIVN LASSE--------------------ASSMKL-----------GKMFSSLG-PQPGQPKM------------- 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---I---------------QRFWL-------------TG-------------A-----CKPKKQNKRA---- ------------------------SEPLALEQFLSAYLLLF-------------SGVLL-ALI----LLLLE HV---------------------------------YF-KY-------V-RKHLAKTD--------------- ---------------------------------------------SGG------------------------ -------------CC--------------------ALISLSMGKSLTFRG---------------------- ------------------------------------------------------------------------ ---------------------------------------------------------AVFEAQN-KLRR--- -----H--RCRDPLCDTHI------------------------W---------------------------- ----------------------------------------KVKHELDMA---RVKIKQLEKE-LES------ ------------------------------------------------HGVKPSRK---------FATSNIL TSCWKPRT-------------------QEADEERDPQILNVYASLA-------------------------- -----TTRAEREMLGSREVFGVRDMTRNHISSNE------PVRPSSTTPTITTTTTTTLTPTPETGARQRT- SMEIR----EIA----------------------EMETVL-------------------------------- >Parg_11039193_IR1039/1-773 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg_11093356/1-854 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----------LQGRQ-LVVTTRE------------------------------------------------- ---------NW-------------------------------------------------P--------FFK -----------------------------------------IQ-----T----------------------- ------------LR-D-------------G--------------------------TVIPISGVD-L----- ------------SLLNTLSK-T----------------------L----N----------F----------- ------------T----YQLVS-PPD---------GK-WGG------------------------------- -----------------------------PQPDN---------------T---I------------------ TG------------------------MVG---QV--------------AR-H--------------E---AH AAIC-----------------------------------------------------------TLTVT---- -DIR---ETV--V-----------DF-T-VP-----YYYQS---VTL-------------V-SPT------- --------------------------------PKE-KN--RSF-------------AVLSP---FT------ ----------------------------------VRV--W-LCI-ILV-------TV-L---SG-----PLL YLV--------------------------------------------------------------------- ---------------------SRL-LVV-------------------------------------------- ---------------------------------------V-----------------TGKE----------- ------------------------------------------------------------------------ ----------------------------------D------------------------------------- ----------------------------GTQH-SLRN-----LSFN---MYR--------SLM-----FQD- --------N-LIN-THRWTHHFILIG------WYL-----FSLYIHAMYSG-----TL-----TA-ALAITA Y--EK-----------------------PID-----SLYDLAQAHRD-------------------GYTI-- -----------ATTRD---------SSYYA----------------TF----K------------------- -------------S----------------------------------AK-SG--------IYQEV------ -WHLFN--------HEEPDK-------------------------------------SFVVAQAA--G---- IDMIL----------K-H-------R-Y-V-FISARLNSELMA----VQ--------------RGRNR---- -----FHIGRQS-FLP-DI-------------------------------------------------IGVA CNTG-S-P-------------------------VRDAFSRI-----------LVRLTEVGMVNK-------- ---W---------------TKDEV-------------NK-------------V---SS-FIST--------- -------------------TSDSGPSAISLQHLQGSFFMMI-------------LGFTT-SAV----VLVME IM---------------------------------GC-IW-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg_11413719/1-484 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------M-------------------------- --------------------SDVRGAVVR--SV----HEAFGD------------------------TVLLP Y--------------------------DPGF-----------LLLTEVLTLNHHHVQAM------------- 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---------------------ARL-LPA-------------------------------------------- ---------------------------------------H-----------------LEGE----------- ------------------------------------------------------------------------ ----------------------------------EEE---------------------------------DD DEV------------------------ASSKL-SLQS-----LSFN---AYR--------SLM-----AQG- --------C-LIT-CQRWSLRLILYC------WYL-----FSLYIYAIYSG-----TL-----TA-ALAITA Y--ER-----------------------PID-----SLYELAQARRD-------------------GYTI-- -----------ATLKD---------TNYET----------------TF----R------------------- -------------R----------------------------------AK-TG--------IYHEV------ -WRLFH--------HEDRDK-------------------------------------SFLPSQDY--G---- FDLVQ----------Q-E-------K-Y-V-FIIAQLNSRLKA----TQ--------------RGREQ---- -----FYIARET-FLP-QG-------------------------------------------------YGIA CSSG-S-P-------------------------FRDVFSRI-----------LIRLTEVGLVNK-------- 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------------------------------------------------------MRESPC------------ -------------------------------------------------SSL-SCALACLLMVVA------- -------------------------------------------------------------------TPAPR SFTHS------------------------------------------------------------------- ------------------------------------------------------------------------ -------------------QSSASPI---------------------------------------------- ---------SSTDPLLS--VSSPG----------------PALLGPAGQDPTPPAVVVSTSPPHAPRNPHPR SQKGEPRRTRNATSFSTKARARRSSSPQRLSRPSISTPEHSAVKAAAAAAAAGAPGSPSDDFGSEKLPGEHL GAGSVLAEDR----SEDRSRDDFDRAAREEGVLRQVAS---------------------------------- ----------------------LLM--------AVRGEQV-------------------------------- ------------------------GRCAAT--------ITSD-QFYL------------------------- --------------------PAVDYSLT---------------------YLAAMNEEQPGSQEQVSPAALFT LPPPP-------------------YQDGEAL------------SSLVAGY-RSLRRETC------------- 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---W---------------FQDLL-------------DK-------------ALQKQRRKARRRQEALQVEP --------------------QYSKTQVLGLYHVQGPFILLL-------------MGWLL-AGA----SFLLE LM---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------T---SRRCRCRE------------ -------------------------------------------------------SGGLSLEDC-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg_11604778_IR1021/1-438 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----------MKKDF-LRIAAEE------------------------------------------------- ----------W------------------------------------------------VP--------WVM ----------------------------------------V-A-----S----------------------- -------------H-N----------------------------------------GTTTIRGPM-A----- ------------NILRVLAS-K----------------------L----N----------F----------- ------------E----YDILR-PED---------LV-WGI------------------------------- -----------------------------PLQDG---------------N---W------------------ TG------------------------MLG---ML--------------QR-Q--------------E---VE MAVG-----------------------------------------------------------PFGVT---- -TSR---LEV--C-----------DF-S-EP-----VYSEN---QAI-------------L-TAR------- --------------------------------PAL-SG--DLS-------------GFLQP---FT------ ----------------------------------LTV--W-LMV-LVA-------TI-S---IG-----ATF AFV--------------------------------------------------------------------- ---------------------S-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------TKE GHLFNF----------------------KHRSSLSAA-----SIW----VIK--------AFT-----QES- --------A-EGL-PRTDGSRLVVGT------WLL-----ASLVFMSCYSG-----IL-----TA-MLTMPR V--TI-----------------------PID-----SLEDLVRQ----------------------TELP-- -----------WRLEG---------GSMMF---------------HYF----R------------------- -------------D----------------------------------AT-EG--------VRKRV------ -FEG-------------RSG-------------------------------------TFVDCWKS--K---- -REIS----------R-G-------D-F-V-GICDVTAMKMVMSWDFST--------------TGRCH---- -----LYIAREA-AYTNLL-------------------------------------------------LSFA YRIN-S-T-------------------------YKHRADYW-----------IMRAKEAGLMDV-------- 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----------------------------------------------------MMLR---------------- P----------------------------------------------------HLTLLFMVLTSSTSVEAQP D-------------------TAGMSSSDRKY-----------------HQDDLPDTIVRVVPS-----HTPL LFT-SEGGPLTEPFQSVSNDGNETPSSEEHLKASVTGSA------ETTDTALRREEATRKYLKVLDV----- QNTKNV--------SMLMMDEASLSQVLGAGDSQELSECVLVLANDGGYC----QQAELRDLLLL------- ---NNLRDAVQINTTEDVQKMVSGSS-------MCHGHLF-------------------------------- -------LWRNPESHFT--PTGSHHDSCSYHD--RTK--RSP--STTGTGDTSC------------------ --------------------------------------------------------------------DNCS LAFTL----------------------VTRNTDEDLTL-----------------VD--------------- ----------------------LVW--------YLISL---TSGR----------QLY-------------- --------------------------------------LVYD-DIM-------------------------- --------------------PGVVD-VVR--SF----QEVFGD------------------------TILLP Y--------------------------DPKI-----------LLLTEALK-SNYHVQAM------------- 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-------MKTRCC----------------------------------------RLLSLLV------------ ------------------------------------------------------VVGVVR--TTAGSLS--A V----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------ISGRVGRRPPEEAEARQL---------------------------------- ----------------------VTE--------VVVRS-L-------------------------------- ------------------------VGCSLL--------LLHD-TH-H------------------------- --------------------ILSPLP--R--PL----------------------------LQHALGLSVVD LLTLDTTTALRL-------------KNKVEEN---------DARVCRSV----------------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------MVDVAR--------RLLKEEL-------------------------------- ------------------------AGCSLT--------VIGG-GREA------------------------- --------------------------------------------------------------AEDFTHLAVN MG------------------------VLYQVS----------SGQLSLENPPNITWWGG------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------MV--TS----YQRLGQ------------------------LIIVR Y--------------------------TSEL-----------EEMEATVR-SHLDVLTL------------- 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---------------------AWL-RQC-------------------------------------------- ---------------------------------------Y-----------------I-QE----------- ------------------------------------------------------------------------ ----------------------------------AR------------------------------------ -----------------------------PQH-SIQD-----FAFN---MFR--------SLV-----VQG- --------N-LLL-ACHWEQRIVFFT------WYF-----FCFTVYAMYAG-----TL-----TA-FLAIPA Y--EK-----------------------PID-----SLWDLLHAVKQ------------------KNYKP-- -----------VVVLG---------TSNEF----------------IF----K------------------- -------------E----------------------------------AK-RG--------IYRDL------ -WQVF-----------DDSE-------------------------------------GYVDTHSD--A---- MDKVL----------K-G-------K-Y-V-FLNAQLGAEIRA----VT--------------RGRHK---- -----YYFARNA-FYP-QG-------------------------------------------------YGIA CTSG-S-P-------------------------FRRVFDKL-----------LTQMSAAGLVQK-------- ---W---------------TRDEI-------------MK-------------A---AKRDNDRAT------- -----------------------GPGAITLRHLQAAFFLLV-------------LGYLL-GGL----ALLME RI---------------------------------RH-RR-------Y-ATTLNQVGQTAT----------- ------------------------------------------------------------------------ ---------------------------------EMMKEKFKNREPMGK------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------LPE-SEK---YGD-------------INIEIN----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg_1625355_IR1033/1-438 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-------------MH-LAVAAEQ------------------------------------------------- ----------W------------------------------------------------VP--------WLR ----------------------------------------ITE-----N----------------------- -------------E-D-------------S--------------------------GELIYSGIM-Y----- ------------NILISLSQ-A----------------------L----N----------F----------- ------------T----YELRR-PPD---------GL-WGV------------------------------- -----------------------------GFPNG---------------T---W------------------ NG------------------------QLG---MV--------------KR-R--------------E---VD LALG-----------------------------------------------------------PFAFN---- -WER--YHFA--C-----------EF-T-QP-----IFVDY---ESV-------------F-MRR------- --------------------------------PRL-ET--DLF-------------ALVRP---FQ------ ----------------------------------WQV--W-LCL-IGV-------LI-L---TW-----FIL VLF--------------------------------------------------------------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------MRYLTPQLFVCIVLVWN RSVGAQDQPFQVHAPEPTTTTASTAT-------T-------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------------T TPVL-------------------------RNMAEDLTL-----------------AD--------------- ----------------------LVS--------YLIGL---TSGQ----------HFY-------------- --------------------------------------LVYD-DVK-------------------------- --------------------PGVAD-VAR--LF----HLRG-D------------------------ITLLP Y--------------------------DPTF-----------HLLAETLR-SYNRVQVT------------- 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---------------------TRL-LVV-------------------------------------------- ---------------------------------------Y-----------------FGEE----------- ------------------------------------------------------------------------ ----------------------------------D------------------------------------- ----------------------------SIHF-SMQS-----LSFN---MYR--------NLM-----VQN- --------N-LIQ-SHHWSLRFIFFC------WYL-----FSFYVYAMYSG-----TL-----TS-VLAIPA F--EK-----------------------PID-----SLHELAQAHDD-------------------GYTI-- -----------STTRD---------TSFEA----------------AL----K------------------- -------------A----------------------------------AK-SG--------IYYEV------ -WQLFD--------HENPEQ-------------------------------------SFLLNPEI--G---- FRMVR----------D-K-------K-Y-V-FINAQLNSKMKA----AQ--------------YGREY---- -----YHIARHT-FLP-QC-------------------------------------------------YGIA CSSG-S-P-------------------------FKDVFSSM------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg_172764/1-782 -----------------------------------------------------MMF---------------- P----------------------------------------------------QWMLWMLVSTFSLCMRAFS G-------------------TTEKTLSSETD-----------------QQDDLPHTLVRVATP-----TTTP VFT--------------------------------------------------------------------- -------------------DAAPLTNKLD-VERRDFRDYNLLLPYDAGRS----KKDLLWDPLLL------- ---RDHPQVTQPNTADDLMRMVSVPS-------TCSSYLL-------------------------------- -------PLDVPGCPFT--TTNIHHDPREYHDSGRTR--RSLVNTGSG-GSTYC------------------ --------------------------------------------------------------------DNCS LALSL-----------------------AMKADQHLTL-----------------VD--------------- ----------------------LVS--------YLASL---TSGR----------QFY-------------- --------------------------------------LVYD-DVL-------------------------- --------------------PGVEG-VAR--SF----QEALGD------------------------TILIP Y--------------------------DQDI-----------LLLTEALT-SGYHVQAM------------- ------RNVFI-------LCT--AAHVA-------------------------------------------- -----------------------ILF-----------EKV------------RKK---VLES---------- -----PT-VQWF-V----------------------------------------------IVDDDLT----- ------------------------------------------------------------------------ ----EELPAL--------------------L----------------------------------------- ---------REGTQVALVQ----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------RVTP--------------------- -------------------YKAKLFSSRV-------------------------------------DFDDKI QFHQVGWW---------------------------------------------------------------- ---------------------------------------------SVSGA-WYIDS---------------- ----------------------------HLVKGG-----L------VPDL-QQL----YSD----------- ----------FQGRQ-LVVTAND------------------------------------------------- ---------NW-------------------------------------------------P--------FFK -----------------------------------------IT-----T----------------------- ------------LE-N-------------G--------------------------TVIPISGID-L----- ------------SLMNALGK-K----------------------L----N----------F----------- ------------T----YRMTR-PPD---------GN-WGG------------------------------- -----------------------------PQPDK---------------T---V------------------ TG------------------------MIG---QV--------------AR-H--------------E---AH AAIC-----------------------------------------------------------EITIT---- -YMR---ETV--V-----------DF-S-YP-----YYLES---STL-------------V-SPA------- --------------------------------PKE-RN--RSF-------------AILAP---FR------ ----------------------------------IQV--W-LCI-CLV-------TV-L---VG-----LLL YVV--------------------------------------------------------------------- ---------------------TRL-LVV-------------------------------------------- ---------------------------------------Y-----------------LDEE----------- ------------------------------------------------------------------------ ----------------------------------D------------------------------------- ----------------------------SVHY-SLQS-----FSFT---MYR--------NLM-----IQG- --------N-LIE-SQRLSIRFIFFS------WYL-----FSLYISAIYSG-----TL-----TA-SFAIVS Y--EK-----------------------PIN-----SLYDLAQAHRN-------------------GYTL-- -----------GSVRD---------NNFVD----------------AL----K------------------- -------------S----------------------------------AK-SG--------IYYEV------ -WPLFN--------HEDPDR-------------------------------------SFVADPNE--G---- IKRVM----------T-H-------K-Y-V-FFNAELNSKLQA----AQ--------------RGQDR---- -----FYLARQT-FLP-QG-------------------------------------------------YGIA CSSG-S-P-------------------------YKDVFDSI-----------LIRMKEAGLLAK-------- ---W---------------ANDEM-------------IK-------------V---SK-NIAP--------- -------------------SVDSGPSPITLQHLQAAFFITA-------------LGITV-STI----ALGIE IM---------------------------------AS-RW-------W------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg_1742393_IR1067/1-595 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------MAAM----------------------------------------------- ---------RRVYPQLM--VASL------------------AVLVICQ------------------------ -----------------------------------------------------------------------D TGGPMTGR-----------EDLGDDLG------RDLGV---------------------------------- ----------------------LVR--------QVVEKRM-------------------------------- ------------------------GQCYLV--------LLGD-ATYG------------------------- --------------------DAIF-YILR--SLDEAG---------------------------IFPRVVVD TDEMANAVDRQET--TGKETTERTSTTGR---------------LLEALR-RRDAGSTC------------- ------WSLVV------DARR--HHQLD-------------------------------------------- -----------------------LIF-----------RFL------------EAI---ELFK---------- ----WPE-TYVVFV----------------------------------------------GPKSGAS----- ------------------------------------------------------------------------ ----G------------------------LLLHH--------SL---------------------------- ---------RNSARPLYLA-YPNHS----------------------H--------EVESL----------- --------------------------------RV-------------------------------------- -DLT-PADSLPVTDSAVVTSR---------------------------------V----------------- ---------------------------------------------EGGSVGPTTRTGSP------------- ------RL----QQMPSKWRWVFLYTRCLYC-----------------------------------KG-GDP SVLFLDTW--------------------------------------------------TYSSGFH------- ------------------------------------------------------------------------ -------------------------------NDA---D-L------FPDY--------FKD----------- ----------FQGHK-FRVVTMN------------------------------------------------- ----------W------------------------------------------------FP--------FIE -----------------------------------------FE----------------------------- -----------RQTKD------------GG-------------------------SLVKPLDSLD-F----- ------------RMLTAIAS-K----------------------L----N----------F----------- ------------T----YEMRV-PWD---------MQ-WGT------------------------------- -----------------------------STDSS---------------N---W------------------ TG------------------------IVG---TL--------------QH-H--------------K---AD FSMM------------------------------------------------------------LSWM---- -ETR---LPV--L-----------DY-S-GI-----YASEP---LVM-------------I-TSK------- --------------------------------PLP-LS--QAF-------------ALVRP---FS------ ----------------------------------VNL--W-VMT-VVS-------TL-L---AS-----LIL WALQQA------------------------------------------------------------------ -------------------WSWAS------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------RGHA---L------------------------------ ---------------------------------TLDQ-----AMLL---TWG--------ILL-----EDP- --------P-VRL-PKNITAQVLLGW------WWV-----YCMLLTITYRS-----SL-----IA-HLTVPG K--SV-----------------------SLE-----SLEELLEAN-------------------RHQRWT-- -----------WGYEP---------TYGSGW--------------EWL----K------------------- -------------T----------------------------------NE-SP--------TVKEI------ -YES-I----------------------------------------------------MVG----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -SKG-G-P-------------------------LAGLELG-------------------------------- ---W------------------------------------------------------------PK------ ----------------------------GISHLR------------------------------------VS QL---------------------------------NI----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg_177228/1-598 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------MTM------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------DHDLTL-----------------ID--------------- ----------------------LVT--------YLISL---TSGR----------QFY-------------- --------------------------------------LVYD-DVM-------------------------- --------------------PGVEG-LVR--KF----QEMFGD------------------------TILLP Y--------------------------DPSI-----------LLLTEALT-SNYHVQAM------------- ------RNVFI-------FCS--VMHVV-------------------------------------------- -----------------------KIF-----------EQV------------RKK---VLES---------- -----PT-IQWF-V----------------------------------------------IVDEDLT----- ------------------------------------------------------------------------ ----EELPML--------------------L----------------------------------------- ---------REGTQVALVQ----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------RVTP--------------------- -------------------QKAQLFSSMV-------------------------------------DPDGQI RFHQVGSW---------------------------------------------------------------- ---------------------------------------------SVSDT-WPTIS---------------- ----------------------------HQVKGG-----L------VPDL-QQF----YSD----------- ----------FQGRH-LVVTTNN------------------------------------------------- ---------NW-------------------------------------------------P--------FIK -----------------------------------------IK-----T----------------------- ------------LQ-N-------------G--------------------------TVITVSGID-L----- ------------SLIVTLSD-K----------------------L----N----------F----------- ------------T----CQFVR-PPD---------GK-WGG------------------------------- -----------------------------PQPDN---------------T---I------------------ TG------------------------LVG---QV--------------AR-H--------------E---AH VALC-----------------------------------------------------------ELFIT---- -SSR---ETV--V-----------DF-T-SP-----YFLGS---TTL-------------V-SPA------- --------------------------------PKQ-KN--RSF-------------AIFST---FT------ ----------------------------------LEV--W-LCI-CLV-------TL-L---MG-----PLL YLV--------------------------------------------------------------------- ---------------------HRL-LIV-------------------------------------------- ---------------------------------------F-----------------LDEE----------- ------------------------------------------------------------------------ ----------------------------------D------------------------------------- ----------------------------SVHF-SLQS-----FSFN---MYR--------NLM-----NQS- --------N-LLT-SQRQSLRFIFLG------WYF-----FSLYIYAMYSG-----TL-----TA-VLAIVA Y--EK-----------------------PID-----SLHHLAQAHRD-------------------GYTI-- -----------STTRD---------SNFEN----------------AF----K------------------- -------------H----------------------------------AK-SG--------IYHEV------ -WQLFN--------HEDRQQ-------------------------------------SFLPNPEI--G---- FDRVQ----------R-Q-------K-Y-V-FINGELSSKLQA----AR--------------LGWHK---- -----FHIGRQT-FLP-EG-------------------------------------------------CAIA CSSG-S-P-------------------------YKDAFSRI-----------LIRLTEAGLVTK-------- ---W---------------TNDEV-------------NK-------------V---SK-FMAT--------- -------------------SSDSGTKAITLQHVQAAFFIMV-------------LGFAI-SAV----FLLME --------------------------------------------------TLD------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg_1803275_IR1066/1-454 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------TD -----------------------------------------YE----------------------------- -----------TIPGS---------------------------------------RVVKPKPSLD-V----- ------------FILDVIAK-K----------------------L----N----------F----------- ------------T----YKLEI-PED---------GL-WGF------------------------------- -----------------------------LKDDG---------------H---W------------------ LG------------------------VVG---DV--------------EF-Q--------------R---AN FSLV------------------------------------------------------------LSVT---- -LER---RIS--V-----------DF-T-RI-----YYRDP---LSF-------------V-TAK------- --------------------------------SRP-QP--PWL-------------KLITP---FT------ ----------------------------------TQV--W-LLG-VAS-------VV-L---AA-----VLY YLIFRI------------------------------------------------------------------ -------------------QSIFG------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------SFV----L------------------------------ ---------------------------------APSR-----AFMH---IFG--------SFL-----SQS- --------L-FVM-PWFSSGKLFLGF------WFV-----YSLLVTTYYKT-----SL-----MA-TLAVPS I--PP-----------------------TID-----TLEQLL-----------------------RSNLK-- -----------FGMID---------AKGSEY--------------QLF----S------------------- -------------T----------------------------------SN-VS--------LYQKM------ -FQKMS----------------------------------------------------FYSSDES------- MRLVA----------E-G-------K-Y-A-YIYFKSNLKTIVSTQYTSI-------------GGKSD---- -----LHVASEE-FFP------------------------------------------GG--------YGWA FPKG-A-P-------------------------YRRTFDDV-----------MWRCVQGGLIDM-------- ---W---------------VRDLY-------------TI-------------YLNENLLQKTPRERKAERE- ---------------SALSKRNDGLVVLNVNHLQGAFLTLF-------------LGSGA-GIL----LLLLE CL---------------------------------GA----------------------------------- ------------------------------------------------------------------------ ---------------------------------KLLRPAGSSRRVSGAG----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------STFKSSLHQHNKSNW------------------------------------------------ ----------------------------------------------HRY---RPKP---------------- -------------------------------------------------SSGSPEVSSGDRL---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg_182216/1-648 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------MGHGNHF-------------------------------- -------LLGRPES--L--PNINCNGLWDFHG---SR--RKR--RSSGTGRTYC------------------ --------------------------------------------------------------------GNCS LAFHL-----------------------ARNMNQSLPS-----------------PD--------------- ----------------------LVT--------YLMRH---TSGR----------QFY-------------- --------------------------------------LVYD-EAR-------------------------- --------------------GGVDG-VVR--TF----Q-MFGD------------------------TILLP Y--------------------------DPSI-----------LLLTEALT-SNYHVQAM------------- ------RNVFI-------LCS--PMNVS-------------------------------------------- -----------------------NLF-----------KQV------------RKQ---VLES---------- -----ST-VQWI-V----------------------------------------------IVDEDLT----- ------------------------------------------------------------------------ ----EELPVL--------------------L----------------------------------------- ---------REGTQVALVQ----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------LVSP--------------------- -------------------QKAQLFSSRV-------------------------------------DPDGQI RFHQVGSW---------------------------------------------------------------- ---------------------------------------------TTN-------S---------------- ----------------------------HQVKGG-----L------VPDL-QQL----YSD----------- ----------FQGRQ-LVVATID------------------------------------------------- ---------NW-------------------------------------------------P--------FVK -----------------------------------------TK-----T----------------------- ------------LA-N-------------G--------------------------TIIPVSGID-L----- ------------SLVSTLGE-K----------------------L----N----------Y----------- ------------T----YRIVR-PPD---------GK-WGG------------------------------- -----------------------------PQPDN---------------T---I------------------ TG------------------------MVG---QV--------------AR-H--------------E---VQ AIFS-----------------------------------------------------------ELTIT---- -ALR---ETV--V-----------DF-T-VP-----YYLGT---TTL-------------V-SPA------- --------------------------------PKI-RN--QSF-------------AILSP---FT------ ----------------------------------LGV--W-LCI-CLV-------TV-L---VG-----PLL YVV--------------------------------------------------------------------- ---------------------TRL-LVV-------------------------------------------- ---------------------------------------Y-----------------LDKE----------- ------------------------------------------------------------------------ ----------------------------------D------------------------------------- ----------------------------SVQY-SLQS-----FSFN---MYR--------NLM-----VQG- --------N-LIS-SHVWSLRFIFFS------WYL-----YSFYIQALYSG-----TL-----TA-VFAVTS F--EK-----------------------PID-----SLHELAQARRD-------------------GYTL-- -----------GCVRD---------SSFVD----------------AF----K------------------- -------------N----------------------------------AE-GG--------IYKEV------ -WKLFN--------HKDPDQ-------------------------------------SFMPTPDA--G---- MDMVL----------K-K-------K-F-I-FINSRMNSKLKA----AQ--------------RGRNK---- -----FHIGRQT-FLP-QG-------------------------------------------------SGIA FSSG-S-P-------------------------YKNVFSRI-----------LIRLTEIGLLYK-------- ---W---------------AEDEL-------------SK-------------V---SQ-FLAT--------- -------------------SNDSGPTAISLQHLQAAFFIIG-------------LGFAS-SAV----VLFLE IM---------------------------------V------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------RRFW------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg_184387_IR1027/1-432 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------MA----------- ----------LNGTD-LRVATGV------------------------------------------------- ----------W------------------------------------------------VP--------WVV -----------------------------------------PH-----Q----------------------- -------------D-Q-------------K--------------------------GVLTATGVL-I----- ------------DLVNILAS-K----------------------L----N----------F----------- ------------T----YTLVE-AID---------GE-WGR------------------------------- -----------------------------ILPNG---------------S---T------------------ TG------------------------MIG---MC--------------QR-Q--------------E---VD MALG-----------------------------------------------------------PFSIT---- -YLR---SKI--I-----------DF-S-EP-----LYIDT---VGI-------------F-LPR------- --------------------------------PRL-ER--DLA-------------GFAKP---LA------ ----------------------------------WEV--W-MVL-LIL-------LA-V---SM-----ALG VLL--------------------------------------------------------------------- ---------------------NWL-AV--------------------------------------------- -----TWD---------------------------------------------------LP----------- ------------------------------------------------------------------------ ----------------------------------NV-------------------------------GKAAG S--------------------------------HLFH-----PIW----IWK--------ALL-----VEP- --------I-EAP-PKSLTGRVLLGS------WLV-----AAGILGAAYQG-----VL-----TS-LLAVPR V--SV-----------------------PVD-----SLRDLVNY----------------------GRMP-- -----------WAIEQ---------GTSLH---------------QLF----G------------------- -------------D----------------------------------AV-AG--------VHKQI------ -HDG--------------SF-------------------------------------LVTSLFEE--R---- -ERVK----------K-E-------R-F-A-IICDFFSMKKIMSDDYGN--------------TGMCN---- -----YYIAKEV-IWS-TA-------------------------------------------------MAFA FPKG-S-R-------------------------LSAHFNKW-----------ILMMKECGLVSR-------- ---D---------------LQQLT-------------AN-------------A---TACMVPPGKEDGVST- -------------------------LVLSFADLAGIFLLLA-------------AGLTI-GLS----VLLVE KL---------------------------------NC-LV-------R-AG--------------------- ------------------------------------------------------------------------ ----------------------------------------STTSLS-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------PGL---SITTS--------------Q---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg_IR4/1-677 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ M--------------------------TVSV-----------AALLLILT---------------------- ------------------VDV--LPSV--------------------------------------------- --------------------------------------AQLPR----RPYGRVRE---TLEV---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------AGGALEAVLA----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------RERP--------------------- -------------------PHCSVIL----------------------------------------LTDGTA SATTVF------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------KVLRGP------------------------WTP----------- ----------LGLAM-FEVVTEDKSRNMTQAQQSWMIGQARQLRQVSGCVTLVVVSDDPAFMAASAEWSLK- GR-----LLTWFNKLLAVTRRPLQDLRHLYTSFSMMNAMLLITDNFASFTRCSIYV-H-LP--------YRP PEAQVVQVASWSTIRGLTLATHLPLFPEKFSKFAYGPMFVAAA-----EEYP-------------------- ----SYVERDPAWT-P-------------G--------------------------QPLNYKGPT-V----- ------------QLLALLAN-S----------------------F----N----------F----------- ------------T----YTFVR-PPD---------GK-WGT------------------------------- -----------------------------KEADG---------------S---W------------------ TG------------------------MVG---MV--------------GR-K--------------E---SD MGVG-----------------------------------------------------------PFSLT---- -AVR---AEM--V-----------DY-M-GL-----VVDDA---LKI-------------I-GGL------- --------------------------------GRP-EV--DPW-------------GFLLP---LG------ ----------------------------------PLV--W-TAI-LAA-------VL-G---GAGD--GVAT F----------------------------------------------------------------------- ------------------------------------------------------------------------ ------AL---------------------------------------------------FP----------- ------------------------------------------------------------------------ ----------------------------------TKCS-----------------TERH----------LEE G-----------------------------------Q-----RILV---FSR--------I-I-----TTG- --------YSPEP-GEWGWERLLLGA------WMV-----MTLLFVRSYDG-----NL-----MS-MLAVRY I--PQ-----------------------PYQ-----SLRDVLDD----------------------LSAT-- -----------MIWPG---------GTNYM---------------QYI----R------------------- -------------S----------------------------------AK-NG--------TFREV------ -VDAEKDG---RLMLI-KST-------------------------------------EFRHVLET------- --LVV----------H-G-------R-H-V-LIVEESEGRSLRADLFTN--------------TGRCD---- -----FYTSRER-FLP-SS-------------------------------------------------MGMI GQKG-H-P-------------------------LVPALSKS-----------IKFVKQFGIYDY-------- ---W---------------MRSFK-------------IN-------------S---SICLHPPTRITVKSS- ---------------------------LALSNLWGMFVVLA-------------SGHAV-ALL----LLCLE LF---------------------------------IA-RL-------G------------------------ ------------------------------------------------------------------------ ----------------------------------------QTQATDLVS----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------CEPLI-PHGLPLEI---------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------------IMFLIVNI------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg_IR7/1-773 ------------------------------------------------------MGRRS----VRQ------ ------------------------------------------------------------------------ --------------------------------------------------------------------RTPL DVRAK------------------------------------------------------------------- --------ILQMW-----------------VR-------------------GF------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------PVR--------HIATEI--GSCR---------TTVY-------------- --------------------------------------RL-------------------------------- -------------------------------------------------------------------QLFGE M--------------------------KWPQ-----------LLLLLLLP---------------------- ------------------FVW--SPSVL-------------------------------------------- ------------------------CG-----------ARLLLS----APRGQDRI---ASAA---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------ARAIIDAVAT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------AAPH--------------------- -------------------PHSSVIL----------------------------------------FTDGST SSIPV------------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------SAGQP------------------------WAS----------- ----------LGVGF-FEVAMDRQDAFLTGAKFSKWSTRPCXFRQLSRWVTMVVVVSDNHLPRRLHPLSFKG GG-----LLLWPTRLLVVTRQPLQELEFLHNTFSKTNSMLAIVNNATEYARCDVYV-Q-QP--------YSQ REDPVLHIASWTPHRGLVQSTHPSLFPDKFSKFCHGPTLVAVS-----EVNPIN------------------ ---KLKITGDSDLD-G-------------E--------------------------QQIVFTGPI-P----- ------------LMMDYLAT-A----------------------M----N----------F----------- ------------S----YKYVL-SPD---------RV-YGL------------------------------- -----------------------------KKDDG---------------S---W------------------ SG------------------------MIG---MV--------------SR-E--------------E---VD IGVG-----------------------------------------------------------PFTLS---- -ATR---AQV--V-----------DF-T-WP-----ILVDH---FRM-------------L-GAR------- --------------------------------GRP-EV--DPW-------------SFLLP---LA------ ----------------------------------PLV--W-VAI-LTA-------LV-A---LP-----TAV FIM--------------------------------------------------------------------- ---------------------S-------------------------------------------------- -----SSL---------------------------------------------------SL----------- ------------------------------------------------------------------------ ----------------------------------KACD-----------------KQRL----------LEE -------------------------------------------TFA---FGR--------VLM-----QQD- --------ISVPA-GWWSWERLVLGV------WMM-----TMLVLTRSYAG-----TL-----MS-LLAVRH V--PQ-----------------------PFQ-----TLRDVLDD----------------------PNAI-- -----------MIWQA---------DSANV---------------QYL----R------------------- -------------S----------------------------------VE-SG--------VFREV------ -HDLEKQD---RILYR-TIR-------------------------------------QYPESIDT------- --LVK----------R-G-------D-H-V-LVLANMGLTMHMARDFTQ--------------EGQCS---- -----LYGSKEE-FLP-NV-------------------------------------------------LAMV APKG-S-P-------------------------IIPAFSKR-----------IMAVTEAGLFLH-------- ---W---------------RDLEE-------------PY-------------A---DLCRLAPTKTTVRAP- ---------------------------LSLNNLWGMLVVLL-------------GGYAS-SSC----VLCLE PL---------------------------------RN-NF-------K-SVWD------------------- ------------------------------------------------------------------------ ---------------------------------------RSTQDSSQISFRL-------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------HK--- -----HQQALAGPRAFPIHVKFTC-------------KNHVLMAC--------------------------- ----------------------------SSVLSF-------------------------------------- --------------------------------------------------ERLLLILSTPRLIS-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------RSSFI------------------------------- >Pcla_11797850/1-660 -----------------------------------------------------------------------M W----------------------------------------------------TTTTVLASLLLLPLLMWVI A-------------------VERTRNS-------------------------YP----------------PS LVK--------------------------------------------------------LTMNHLAYS---- ------------------------------------------------------------------------ ---Y---------------PLDGQPG-------TLREQET-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------QQVMT-----------------A---------------- ----------------------LLT--------FLGES---GPGQ----------HLH-------------- --------------------------------------LIHD-DTA-------------------------- --------------------PEVKA-AVR--EW----QQQWVE------------------------VTIVG N--------------------------TSDV-----------TLLQTVLT-SVQLGRRQ------------- ------RRLLL-------LCS--LQNTL-------------------------------------------- -----------------------RVF-----------DAV------------KEK---NLES---------- -----SA-VYWY-V----------------------------------------------ILQSDFT----- ------------------------------------------------------------------------ ----EELISH--------------------L----------------------------------------- ---------REGTQMTAAV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------RTAD--------------------- -------------------MRYRLLTSYV-------------------------------------DIHNQV RLKAVGWW---------------------------------------------------------------- ---------------------------------------------WWSRD-SGGR----------------- ----------------------------HVASSS-----L------TPDL-QQV----YRD----------- ----------FGGRT-LTAAVVD------------------------------------------------- ---------DW-------------------------------------------------P--------FFK -----------------------------------------VT-----P----------------------- ------------VS-T-------------T--------------------------HAIPDSGID-Y----- ------------QVLTSLAL-K----------------------L----N----------F----------- ------------T----YKVKL-DPK---------GQ-WGG------------------------------- -----------------------------PQPDG---------------S---V------------------ IG------------------------MIG---MV--------------AR-R--------------E---AD LAIN-----------------------------------------------------------EITIT---- -GPR---ETV--V-----------DF-T-VP-----YFMES---TTI-------------V-TPA------- --------------------------------PKE-KS--KAG-------------AIFSP---FT------ ----------------------------------PLV--W-LLL-VAA-------TL-A---IG-----PVL SSV--------------------------------------------------------------------- ---------------------SWV-MEL-------------------------------------------- ---------------------------------------Y-----------------TGKK----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------WDR-SIQQ-----YTFN---MFR--------NMV-----VQG- --------N-LIV-SGYWPHRIIFLS------WYL-----FTFYVFALYSG-----TL-----TA-VLAIPS F--EK-----------------------PID-----SLVDLLNAIKK------------------DGFIP-- -----------MVAYG---------TSNEF----------------LF----K------------------- -------------E----------------------------------AT-SG--------IYRDI------ -WHMF-----------TPSL-------------------------------------GYARSFDE--G---- VEKVP----------T-G-------K-Y-A-FVNAWLACEIRI----RK--------------IGSSK---- -----FYMARQT-FYP-QG-------------------------------------------------YGMA LVSG-A-P-------------------------YKNVFDQT-----------LLQLRESGLVDK-------- ---W---------------TKDEV-------------SK-------------L---KRQDKSGRSS------ ----------------------SLPGAITLLHLQAAFFLLL-------------SGFSL-ASA----VLITE IF---------------------------------I------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------FAPH-EKKHHRM-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla_1600198/1-582 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------VYP-QGEG--AVSP------------------- -------------------ACVVRGGLLP--RLWAE------------------------------------ ------------------------------------------GRTVSTLLYHHNHSATIF------------ ----NHINFVL------------------------------------------------------------- ----------VYTNV------TKDVL-----------NKA------------SDSG--KLER---------- --------TQWLVL---------------------------------------------L--EKEDQ----- ------------------------------------------------------------------------ ---------------------------LATL----------------------------------------- ---------HDHVNALDLF---IDSTL-----------------------------LLATF----------- -------------------------------------------------------------RPCQA------ -QY---------------------------------------------LQSVYRV----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------GPKSRV LVEGGGEW--------------------------------------------------SPTDGYVGV----- ---------------------------------------------------AAGNKYDR------------- ----------------------------------------------------------RRN----------- ----------FQGYP-IVGVGVK-------------------------------VFD--------------- ------LYTTY------------------------------------------------LP----------- ------------------------------------------------------------------------ ---------------N-------------GRL-----------------------------SGYI-G----- ------------DILNVLKM-A----------------------H----N----------F----------S L-----------S----YSILK-------------GYAYGS----L-------------------------- -----------------------------VNGSS---------------N--KW------------------ TG------------------------MVG---EL--------------QQ-G--------------R---AD LTVS-----------------------------------------------------------ELSIT---- -KER---NDV--V-----------TY-T-QP-------------------VF--------VVSRRLY----- ---------------------------VST--PQDFRK--KLL-------------AYVDP---MD------ ----------------------------------KVV--Y-VCV-FVA-------MS-V---MA-----LGL NFVERL------------------------------------------------------------------ -----------------------------------------------------------RL----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------YFL---PSE-------EEPV------------- ---------------------------------SLSV-----AAWS---MVS--------ALL-----QQG- --------Y-DPT-PSSTAARIIFWV------GFV-----VSLIVYTAYSA-----TL-----MA-HLAVEK PA-PL-----------------------PFS-----NLRQLSRQTRW-DAGPN------------------- -------------------------------------------NNDLF----Q------------------- -------------VTASQT------------------------CVGSQTE-ECR-------VMQDV------ -WNKVVLR---SP------G-------------------------------------NIVNSYNE--G---- LQKVL----------K-G-------K-Y-V-FIGVDVNTNYYI---------------RNLPSKDACR---- -----VKELPGQ-YIT------------------------------------------GG--------IAIG LQKR-S-P-------------------------FRGVFDYS-----------LQRMKEIGVMKR-------- ---L---------------VATWL----------------------------KVGRS-CSLQTTVNA----- ----------------------------SLTDLAAVFILLF-------------MGISA-SLL----VLGGE IV---------------------------------VS----------------------------------- ------------------------------------------------------------------------ --------------------------------RSKK--RQPTHDDT-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla_1619010/1-684 ------------------------------------------------------MAAQ---V---------- -------------------------------------------------WRR-RLGMVLLVLWRATWTSG-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------FLQSPEGQMF---------------------------------- ----------------------FTA--------YISALGV-------------------------------- ------------------------KCVNVF--------LPAG-SMGG------------------------- --------------------GQVPVGVLR--AAWSGT---------------------------PLSLALKR VRSGRDVGVALA---------------------------------TEGM----------------------- --------------------T--S-TLN--VAFLHAREDL-------------------------------- -----------------------SLF----------VEVTHE-------S-LVRH----------------- --------HSWLVL----------------------------------------------GDSRLLT----- ------------------------------------------------------------------------ ----------------------------QAGLTP--------RL---------------------------- ---------PLDNLVTFASF---N------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------WTETNTTNV------------------ -------------------TRVDLSEIYT---------I---------------------------RPDLPF VTHRLGSW--------------------------------------------------RPLASLK------- ------------------------------------------------------------------------ --------------------------------LP---E-E------HWSE-R------RTN----------- ----------LTGLH-LRCVTLS------------------------------------------------- ---------------------------------------------------------Q-PP--------FLT -----------------------------------------VG----------------------------- ---------------P-----------------------------------PDQEGRAALVAGYV-K----- ------------DVWDALQD-I----------------------H----G----------F----------- ------------T----YACRL-PED---------GA-WGS------------------------------- -----------------------------QSPDG---------------R---W------------------ NG------------------------LVR---EV--------------VE-G--------------R---AD VVVA-----------------------------------------------------------SLDHN---- -QAR---AKA--I-----------DF-L-FG-----LKEVG---YRM-------------V-VRR------- --------------------------------PGL-G--EQPWK------------SFTAE---LL------ ----------------------------------PDA--W-LGT-IAF-------VV-F---VP-----PCL ALCAYF------------------------------------------------------------------ --------------------S--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------PFET-EVV------------------------------ ---------------------------------TLKD-----AYIV---TIG--------ALA-----IQG- --------S-WLE-VQSTSSRIVFTT------IFF-----ATLLVYAYYTS-----AL-----VS-ILTVAS T--NT-----------------------GFS-----SLQSLLQDGT--FQ---------------------- -----------FGFAT---------GTFLE---------------EEF----K------------------- -------------N----------------------------------AK-QL--------LFKEV------ -WQRLVAP---DP------S-------------------------------------NLVHSHQE--G---- IRKVI----------K-E-------S-Y-V-YMMEENGFHSLLEEQ--------------------CE---- -----VVLAEGL-YFS-TQ-------------------------------------------------TGLA LDFD-S-P-------------------------LKRVFDAQ-----------LMRLRDGGLLSR-------- ---L---------------WQKWQ-------------PPPTL----------------CTDPGVI------- --------------------------ALNMRHLFTAFLLLL-------------LGVVL-AAL----LLPCE RL-------------------------------------H-------W-NIIGKT----------------- ------------------------------------------------------------------------ -----------------------------------KAARDNRLRRE-------------------------- ------------------------------------------------------------------------ -----------------------------------------------------QGNSRSHMVGG-------- ------TLRNTGPSRAWVANHNRL-VATLP------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------SQNHKELIAINRGFRTYLRY---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla_1704222/1-710 ------------------------------------------------------MV--------------C- A----------------------------------------------------SFYLIYLMC----DMWVIP G-------------------AAK--------------------------------------PS-----DLPL LYQ---------PS---------------------------------------------------------- H-----------W----------------------------------------------------------- -----------------APSLASATA-------TTS------------------------------------ -----------PSS---------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------SYSHRQERAGR-----------------DE--------------- ----------------------VAA--------LLTLL---TLDLPQ-------PNLY-------------- --------------------------------------LLHD-QSF-------------------------- --------------------LGGAV-LRR--GRPPGAEEVLGGF--Q--------------QASGRPVTVLR LFQGHDSQGHDSQ-------GHDS-QGHDDL-----------SLLQEALTLPQTHS-GF------------- ------KHFLV-------LCS--LKHTL-------------------------------------------- -----------------------SVF-----------QYV------------REK---QLES---------- -----PR-LWWLVV----------------------------------------------VVEPEAP----- ------------------------------------------------------------------------ ----DTLQHQ--------------------L----------------------------------------- ---------WEGSLVTLAV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------RTTP--------------------- -------------------TTYTLMTSRV------------------------------------AASSGLP RLEAIGTW---------------------------------------------------------------- ---------------------------------------------EVGPG---GPR---------------- ----------------------------GHLTEP-----L------LPDP-NTL----YGN----------- ----------MGGRQ-LVVSANA------------------------------------------------- ---------DW-------------------------------------------------P--------FFG -----------------------------------------LK-----S----------------------- ------------LP-G-------------G--------------------------GVQPDSGID-I----- ------------QIMNTLGQ-F----------------------L----N----------F----------- ------------T----YRVVS-PAD---------GQ-WGG------------------------------- -----------------------------PLPDG---------------S---V------------------ SG------------------------LIG---QV--------------AR-R--------------E---SH LAIC-----------------------------------------------------------ELTIT---- -ANR---ETV--V-----------DF-T-TP-----YYLET---VTL-------------V-SRA------- --------------------------------PAE-KS--RAF-------------AVFST---FT------ ----------------------------------TEV--W-VCI-LAS-------TV-A---VG-----PLV SVV--------------------------------------------------------------------- ---------------------GRV-VAL-------------------------------------------- ---------------------------------------Y-----------------TERP----------- ------------------------------------------------------------------------ ----------------------------------P------------------------------------- ------------------------------HR-QLPE-----YSFH---VFR--------SLV-----SQG- --------N-LLR-PSNWPHRLLFFC------WYL-----FCFYIYALYSG-----TL-----TA-VLASPT Y--EK-----------------------PID-----GLVDLPKAAAE-------------------GYTI-- -----------GTTSD---------SSLEF----------------IF----K------------------- -------------E----------------------------------AT-EG--------IYKQV------ -WQLFN--------HKDRSK-------------------------------------SFFRSPEQ--G---- FAKIL----------V-E-------K-I-V-VVNAQLNSEVRA----AQ--------------HGRES---- -----YHMARNT-FYP-QA-------------------------------------------------YGIA CNKG-S-P-------------------------FLPKFNQM-----------LRRITEAGLIMR-------- ---W---------------KEQEI-------------SK-------------I---SGRSPSRRG------- ------------------LSSDRGPSAITMKHLQAAFFVLL-------------LGLVV-GLL----MLGAE AA---------------------------------LS-ML-------W-LP--------------------- ------------------------------------------------------------------------ ------------------------------------KTLHQEAHPSQ------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------AW-----------------FPHQW--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla_1961238/1-703 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------MA-----------------A---------------- ----------------------LVS--------FLLAKI--SSLR----------QIV-------------- --------------------------------------IVYD-ESF-------------------------- --------------------PGVTE-TVR--WG----FSSWAD------------------------TTIIR Y--------------------------DAFT-----------THLQTSLS-VVDRVAGV------------- ------RTVVV-------LCL--PENTS-------------------------------------------- -----------------------TLM-----------AAV------------RQR---SWES---------- -----TT-IHWL-I----------------------------------------------ILEKDIT----- ------------------------------------------------------------------------ ----QIIQDS--------------------L----------------------------------------- ---------REGSQVSMAV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------RRDE--------------------- -------------------GGYTILSFFI-------------------------------------HVDNSV RFRVAGRWVDQGAT---GQRGYVVGALF----------------------------------PDLDLL---- --------------------------------------------YRDQGA-TGQR----------------- ----------------------------GYVVGA-----L------FPDL-DLL----YRD----------- ----------LQGRQ-LTVATVN------------------------------------------------- ---------NW-------------------------------------------------P--------FFQ -----------------------------------------LT-----V----------------------- ------------LA-D-------------G--------------------------RREPLAGID-V----- ------------NVVNTLSE-H----------------------L----N----------F----------- ------------T----YQVVE-PAD---------RR-WGG------------------------------- -----------------------------PGQDG---------------S---V------------------ SG------------------------MVG---VV--------------YR-H--------------Q---AH LALG-----------------------------------------------------------ELTIT---- -EQR---ASV--V-----------DF-T-NP-----YFMES---TTL-------------V-SRA------- --------------------------------PAE-KN--RSF-------------AVFYP---FT------ ----------------------------------LKL--W-ALV-ITV-------TF-V---MG-----PVG YLV--------------------------------------------------------------------- ---------------------QWG-HEQ-------------------------------------------- ---------------------------------------------------------VTEP----------- ------------------------------------------------------------------------ ----------------------------------GVTT-----PPPATVS-----STPLHT------HTFSS TEILRRNGWRGASLRPSLLQEAPASFRRSSTP-SLQN-----YSFN---IFR--------SLV-----LQG- --------N-FIS-GSGWPVRLVLFS------WFA-----FCVIVYALYAG-----TL-----TA-YLTKPT F--EK-----------------------PID-----SLQELLEAADK-------------------GVVP-- -----------AVQPG---------TSNEQ----------------LL----K------------------- -------------S----------------------------------AE-SG--------VLQGL------ -WRAT-----------DPSR-------------------------------------SFPANGQE--A---- MLKVL----------T-E-------D-V-V-YMTASLNAEIRA----TQ--------------RGRRR---- -----FHLARQT-FSP-QG-------------------------------------------------YGLA CTTG-S-P-------------------------FRHTFEAL-----------LGRMVQAGLVNK-------- ---W---------------VNDEM-------------NK-------------L---RRKSSQVEVETQ---- --------------------DVIT-RALSLTHIQGAFIILV-------------SGFLV-STT----VFLLE YR---------------------------------RR-S--------T-VDFTTTVRPVSAY---------- ------------------------------------------------------------------------ -----------------------------------------TSRPGSP------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------GPT-PDLHPSSRV-------------TRPHT------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PhumIR21a/1-721 ------------------------------------------------------------------------ --------------------------------------------------------------IS-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------DDIKI------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------NDDF--------------------LRPQKNKC------------- ------THYLL------FSPD--LNWTT-------------------------------------------- -----------------------IVV----------GPQT------------VSKV--VVVTL-S------- --------TRWKIE---------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------EYLRKP--------ES---------------------------- ---------RKIVNLLIVS----------------------------------------------------- ----HVLKQDI--------------------------------------------------------FF--- -----GLEERFNLSQYTN------------------------------------------------------ ------------------------------------------------------------------------ -----------------------LYTHNLLT-----------------------------------DPIGSS TVEFLTSW---------------------------------------------------------------- ------------------------------------------RCGKLSR----------------------- --------NQN----------------------------L------FPQK-------MKKG----------- ----------FNGKQ-FVISASE------------------------------------------------- ---------------------------------------------------------Q-PP--------FTF --------------------------------------RKKI------------------------------ -------------TLE-------------E-----------------------DLNDSKLWDGVE-I----- ------------RLLRLLSD-F----------------------L----N----------Y----------- ------------T----IEIHQ-PKTS-------ISDTKGP----S-------------------------- --------------------------------EI-------------------------------------- --------------------------VIE---DI--------------IS-G--------------T---AE IGSA-----------------------------------------------------------GVYVT---- -NQR--LSDI--------------WL-S-AQ-----HTTDC---AAFIT-----------KATTS------- -------------------------------LPR--------YR------------AILGP---FQ------ ----------------------------------LSV--W-ISL-TITY------LI-AIIPLTFADSHSLK PLIRNP------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------W--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------LFEE-----MFWH---VFG--------TFTN-LFTFTE- --------KKSWTKSKKNASRLLIGW------YWA-----FSVIVTACYTG-----SI-----VS-FITLFV F--PD-----------------------VID-----NVDQLVKMNFR------------------IGSLSIY FFFKANLLISMYKIRKKRNMIHPSGTAGWD---------------TWF----N------------------- -------------N----------------------------------SD-HE--------KTKWL------ ----------------LRDV-------------------------------------ELVPNTTQ--G---- LKNVSNSFYLPMFR-----------P-Y-A-FLAGRAQMEYIIQANYT-------------SSKRKEM---- -----LYISKEC-FVP------------------------------------------FG--------VSYV FPRN-A-I-------------------------YADKFSEY-----------ILRIQQSGLMGKLLNEFK-- ---WEI-------------ERSS--------------------------------AGKLLQA-SSGVPLKE- --------------------IVPVQRKLTLDDTQGMFLLLG-------------AGYLI-AIV----AFITE II---------------------------------VYCKKN------K-RNMDETSKLPNLKVY-------- -----------------VLSVRSL-LRLQKEN---------------------------------------- --------------------------------------NSPHSQQITSSKQ--PIDIRKYKNFDSYDPRDND KGFLHNR----------------------------------------------------------------- ----------------------------------------------------KDKTFFEENITT-SLES--- ----------------------LS-----------------------------------------------K NYVND-----------------------------------------------GNRKSTVSLT---------- ---------------------------------------------------WDEDCSSLHKRQKFTR----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------VRTS------------------------------------------------------------ >PhumIR25a/1-887 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------M-----------NFIRRNPKI----------------G-VQVEE--- --LTRVNVNE-TDAKTI--LDKLCKEYGESVKSG--R-MPHVVL---------------------------- ---------------------------------------------------------------------DAT LTGV--------------------SSETVKSFTSALAI-----------------PTVSMSYGQEYDIRAWR NLDKEDEKYLIHI---MPPGDLIPE--------VVRSL---VLA-QN------ISNA--------------- -----------------------------A--------ILFD-DSFV------------------------- ---------------------------MD--HKYKSLLQNV-----------------------PTRHVISP VE----------------------NS--KTI-----------KKQLTKMIDLDVVN---------------- --------FFI-------LGR--MSTIK-------------------------------------------- -----------------------MVL-----------DHA------------NIN---KYFG---------- ----KKY--SWHAI----------------------------------------------TKD--------- ----------------------------------KESIKCS---------CTNATVLFLRPEPD-------- ----PDSRDRLGKLQSTYSLTFE-----PEI----------------------------------------- -------------SSAFYF----E--------------------------VIFR--TLMSV-K--------- ----KMLDDGE-------------------------------------------WPRKMEFVLCE------- -DFN-ENKVPKRTN-LDLRKA---------------------------LQDYN------------------- -----DPPFYAPLII------------------------------DKNGYSFME------------------ -------------------FNVKIEKATIIN-------------------------------------SQTV SAEDMGEW--------------------------------------------------KASLN--GQ----- --------------------------------------------IKI------------------------- ----------------------------KDPTSL------------------------SNF----------- ----------SSVTV-YKVVTVI------------------------------------------------- ---------------------------------------------------------Q-HP--------FIY ------------------------------------------Y-----D----------------------- --------PDSKDK-D-------------NP-----------------------------YSGYC-I----- ------------DLLEEIRK-L----------------------I----K----------F----------- ------------D----YVIYE-APD---------KK-FGT------------------------------- -----------------------------MDDKG---------------Q---W------------------ NG------------------------MIK---EL--------------IE-K--------------R---AD IGLG-----------------------------------------------------------SLSIM---- -AER---ENV--I-----------DF-T-VPY----YDLVG---ITI-------------L-MKK------- --------------------------------TKT-PT--SLFK-------------FLTV---LE------ ----------------------------------NDV--W-FCI-LAA-------YF-F---TS-----FLM WIFDKW------------------------------------------------------------------ --------------------SPYS-YQN-------------------------------------------- -----N------------------------------REKY-----------------KDD------------ ------------------------------------------------------------------------ ----------------------------------EEKR-EF------------------------------- ---------------------------------NLKE-----CLWF---CMT--------SLT-----PQG- --------GGEA--PKNLSGRLVAAT------WWL-----FGFIIIASYTA-----NL-----AA-FLTVSR L--DT-----------------------PVE-----SLDDLSKQY----------------------KIQ-- -----------YAPIN---------GSSAM---------------TYF----E------------------- -------------RMADIETRFYEIWKDMSLNDSLSEVERAKLAVWDYPV-SD--------KYTKM------ -WQAMKEA---GL----------------------------------------------PQTFDE--A---- LERVKNSTSS-----S-E-------G-F-A-FLGDATDIRY--------------------QFLTTCD---- -----FQIVGEE-FSR-KP-------------------------------------------------YGIA VQQG-S-P-------------------------LKDQFNNA-----------ILQLLNKRRLEK-------- ---L---------------KEKWW-------------TN-------------NPKKMICEKHDEQ------- ------------------------SDGISIENIGGVFIVIF-------------VGIGM-ACV----TLAFE YW---------------------------------WY-KY-------K-KNP-------------------- ------------------------------------------------------------------------ ------------------------------------RIEA-TNEKEN------------------------Q RK----INT--------------------------------------------------------------- -----------------------------------------------------WNTQDRF--GP-DFK---- ----------DYYTR--------------------------------------------------------- ----------------------------------------------NAF---QTR--PG------------- ---------------------------------------------------RFKDLNSLAKIET-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PhumIR40a/1-610 -----------------------------------------------------------------------T PTF--------------------------------------------------CFSYMKIFFFLFN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------F----------------------------------------------------------- --------------------------------------------------------------GGI------- ---------------II------------------------------------------------------- -------RGH-------------------------------------------------------------- -------------------------------HLTENDFDD-------------------------------- ---------------DEDMMMSLSLA----VKDIIIGLPS-------------------------------- ------------------------SHVTLL------------------------------------------ ---------------------------FE-----------------------------------NITDSTFP MI---------------------------------------------------------------------- ------------------LSKTLQKSLI-------------------------------------------- ---------------------TTSIY------TIEKGE---------NQKEVEQE---DLMHR--------- -------KILYILY----------------------------------RDH--------------------- ------------------------------------------------------------------------ ------------------------NLRDNDFFSG--------QF---------------------------- ----------EAMRISLLT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------KTQNGMFVR------------------ -----------------YKFFLKIFF---------------------------------------------- ----FFFF---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------L---------------------------ENL----IYN----------- ----------RSTRF-FS------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------DDKLLTIIAQ-K----------------------L----N----------F----------- ------------R----YKYVD-PPERL----------QGT------------------------------- ----------------------------GIFTNG---------------T---F------------------ SG------------------------VLG---QV--------------WQ-R--------------E---FD FFMG-----------------------------------------------------------DVTIT---- -YDR---AKT--V-----------EF-T--------FFTLVDS-EAF-------------V-THR------- --------------------------------PSK-LN--EAF-------------ALIRP---FQ------ ----------------------------------WQV--W-PPI-LCT-------FT-I---YG-----PIL FFIIESQNYLM------------------------------------------------------------- --------------------------KIKRDSKE-------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------RKK---------------------------------- ---------------------------------LFFH-----CVWF---SIS--------TFL-----KQG- --------G-IYP-SKSHKVRLLLII------VTLA----ATYVIGDMYSA-----NL-----TS-LLARPG R--EK-----------------------PIT-----VLEQLDTAMET-------------------RGYQ-- -----------LLVEK---------HSSSL---------------TTL----Q------------------- ------------------------------------------------NG-TG--------IYEKI------ -WEKMKNQK-----------------------------------------------NYLIESVES--G---- MKMVR----------K-N------KN-I-V-ILGGRETLYFDSRRFGSYN---------------------- -----FQMSE--KLNTRYA--------------------------------------------------GIA MQLG-C-P-------------------------YIENFNKI-----------LMQLFEGGILTK-------- -----------------MTVEEYE----------RLGEEQRAEF-EN-----VKKKKNVSQIKNEDIQV--- -------S-TTHA-----------LQPLNTKMLQGAFYILF-------------IGYLL-SGF----TLFLE I----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------QFENICRFLKLIKCHPFI------------------ ------------------------------------------------------------------------ -------------------------------------KSI---------------------KFNKFFNKIY- ------------------------------------------------------------------------ -----------------------------------------------------RKKF--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PhumIR41a/1-599 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------SELVEQ---IIIKNFNNNRC-------------------------------- ------------------------------------ITFITD----NFYESISLPYN--------------- -----------------------------------------------------------------QSLFIIY LKKNENLE---------------------------------NMLMTNSFE------QGC------------- ------GGFIIQ----------VKKSCA-------------------------------------------- -----------------------RFLIE--------RLVAAK----------KKSVCCRYNN---------- --------QKYIFL----------------P-----------------------------NQYEDVN----- ------------------------------------------------------------------------ ---------------------------LDLVNLP--------YM---------------------------- ---------YFFPNIAFIS----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------FLLNNESG----NH--------------- ---------------------FSIYGSTYFN--------------------------------NYKYKILKV TSEILDYW-------------------------------------------------SFR-DGFKY------ GT---------------------------------------------------------------------- -------------------------------------N-L------FPDR--------IKN----------- ----------VMGYK-FFFASLN------------------------------------------------- ---------------------------------------------------------Y-SP--------FGL IINE-------------------------------------------------------------------- -------------------------------------------------------NNKTVFDGFE-T----- ------------RIAGLFVE-I----------------------I----N----G----------------- ------------T----W--DGLSHDT-----------WGE------------------------------- -----------------------------VLPNG---------------T--------G------------- TG------------------------ILR---SI--------------MD-R--------------K---AE FGYS-----------------------------------------------------------GIYQW-FC- -TD---------V-----------DC-S-FP-----YYQSG---VTC-------------L-VPR------- --------------------------------PELVSE----------------WLTIVLP---FR------ ----------------------------------LNT--W-IAL-VFV-------YI-L---NI-----IFF LFSLSA------------------------------------------------------------------ -------------WN--CLTGSSIFKKIG------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------R-------- ---------------------------------NIND-----SFFT---IFR--------IQM-----EQIP ----------KMT-TLNNATVVYLKF------AIL-----YSFFMAVFWRG-----GI-----SS-ILTVPR Y--EK-----------------------PID-----TALDLVNKW---------------------PKIR-- -----------WGGNSN----------------------------LWVHSI-K------------------- -------------R----------------------------------ST-DPT-------LI-QI----VN KFVSLDDDT----------------------------------------------LKKKTETKDF--G--FF IEELP-------H----G-------H-F-G---------------------------HNEYINEDGMK---- Y----LRLMKEKIYKA----------------------------------------------------FGVI ILPR-GSP-------------------------FTEKLDLW-----------LLRMFDTGIVHK-------- ---TEN-----------QVVVERA--------K----NR---------------LQNMIGSSNEKKT----- -------G----------------SVTLALRHIRGPLYIYF-------------FGIII-ACV----VFLFE VF---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------PLI--------------------- ----------------------------------------------------LKKSI--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PhumIR68a/1-691 ------------------------------------------------------------------------ -------------------------------------------------------------------FSSIN S----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------I------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------LDY---------------------------------- -----HEDYLLH-----PDLEPLVTS-------IILK-TG-------------------------------- -----------------------NFKC-LA--------IICD-ELYQ------------------------- --------------------DVFGSYFFH--KITQ------------------------------ATFFKI- -----------------------LINDTEDLISPNY----NTLSTIKKVR-----RNGC------------- ------PIYII------FLAN--GKQVK-------------------------------------------- -----------------------RFL-----------HFG------------DKY---RDLD---------- -----VR-ANFILL------------------------------------------YDDRLFEPDLF----- ----------------------------------------------------------------------Y- ------------------------------L------------W---------------------------- ---------KKMINVVFIR----------------------------------------------------- --------------------------------KFSGG----------------------------------- ------------------------------------------------------------------------ ---------------------------------------------ERSSSN--------------------- --------------------WYELSTVPF-----------------------------------PAPIKEVL IPRRLDIW---------------------------------------------------------------- ------------------------------------------------------------------------ --------R-----------------RGYFYSNV---E-L------FREK--------TSN----------- ----------LRSQI-FRVITFQ------------------------------------------------- ---------------------------------------------------------H-VP----------- ---------------------------------------SAFK-----MP---------------------- ----------GPVMSDDV----------TLEG----------------------TLPIG-YTGLE-I----- ------------EVLNTLSI-I----------------------M----N----------F----------- ------------V----AEVY---------DVPSSEK-WGW------------------------------- -----------------------------KQVNG---------------S---Y------------------ SG------------------------LLG---EI--------------VS-G--------------R---AD IALG-----------------------------------------------------------NLYYT---- -PYH---LGL--M-----------DL-T-IP-----YNTQC---LTF-------------L----------- -------------------------------TPEL-LT-DNSWE------------TLLLP---FR------ ----------------------------------GYL--W-LGV-FLS-------II-T---AG-----IAF VSLAKF------------------------------------------------------------------ -------------------------HRRF------------------------------------------- GYDITQSI------IYSKGK-----------HKSRPKILY-------------------KKRKK-------- ------------------------------------------------------------------------ --------------NL--------------------MG-LYQFE------------NPI------------- ------------------------------------N-----SYLY---TYS--------MIL-----QVS- --------L-PKL-PQGWALRIFTGW------WWI-----YCILLAVAYRA-----SM-----TS-ILANPS P--RV-----------------------TID-----TLEQLAESQIS-VG---------------------- -------------------------GWGEE-------------IKLFF----E------------------- -------------T----------------------------------SL-DA--------AGQTI------ ----------------SRKF-------------------------------------EIENDIDK--A---- VERVA----------D-G-------N-F-A-YYENIFFLRHASVHKKMLILEEEAITKKPKEENEKKN---- EFQKSLHIMKDC-VIN-MP-------------------------------------------------ISLG LQKN-S-P-------------------------LKPRIDKF-----------LQMIIEAGLVKK-------- ---W---------------LNDAM-------------SQVLRA----------------------------- ---------------DAGSEEEPIKAFMNLKKLYGALVTLG-------------IGYGL-SIL----ILIIE KI---------------------------------IW----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----HFTVVKSPFYDKYSNSVIK-----------IVKT--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PhumIR75d/1-643 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------M----FSKKKIQ-------------------------------------------- ------------------------------------------------------------------------ --------------------------FNYYDLNN-FNDFN-------------------------------- -------NFSFDI-----------FQ-----WKLL------------------------------------- ------------------------------------------------------------------------ -----------------------KIGI------------------------------------------IVD L--------------------------------------------------------KCPRS---------- ------MT-FL------------QK-AS--------------------EK---------------------- ----------------------NLFI----------YEF-------------AP------------------ --------IHWLIFTNNHVTRKQLITMV---------------NDY---------VYLK-DDNNPLD----- ------------------------------------------------------------------------ -----------------------------FLMESYDDKKFENELFVINKKVNFDFFFNETEKGEKGKNNNNN NRKVKLN--VNETDINQILHLT----------------------------LLLDN----------------- ------------------------------------------------------------------------ -KVT--------------------------------------------LSVPGF------------------ -----------------------------------------------DNSK--------------------- --------IL-----------YN--LYEIYKVTSRSN----PKI---------------------------- DENGIVFY--------------------------------------------------EKNDD--------- ------------------------------------------CLFKI------------------------- ---------------------------------N------------------DT--IIRKN----------- ----------FMGSL-IRAGAT-------------------------------------------------- -----------------A---------------------------------------F-QP----KA----- ----------------------------------------FTT----------------------------- -----------IDDVS--------------------------------------SREVDVWAKMV-Y----- ------------EHVKILEQ-D----------------------L----N----------F----------- ------------R----SIIRY------------FND-VGYIK----------------------------- --------------------------------NG---------------S---F------------------ GH------------------------LMG---SI--------------QE-K--------------K---SE ISAT-----------------------------------------------------------GVLLR---- -SDR---FGI--V-----------DY-IICP-----FRLG----VGL-------------V-FKE------- --------------------------------PSLPTVK-N---------------IFILP---FT------ ----------------------------------GTV--W-ISI-GIL-------FI-I---II-----IFM RL---REIII-------------------------------------------------------------- --------------------KKFLFKKM-------------------------------------------- -----KL----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------RN---------------------------------- ----------------------------------ISE-----LCMQ---ILG--------AIC-----QQG- ---------LTEN-SKWTSDRVIISF------LLL-----TALILYFAYSA-----SI-----VTFLQ-SSS ---S------------------------AIS-----TIEDVTSSNLE------------------------- -----------VGVQA----HFPYLDVLMK------------------------------------------ -------------E----------------------------------AS-HR--------ITKEY------ -YKK-KIF----NKGRE----------------------------------------NVYFEQRE--G---- INKIR----------T-G-------L-F-A-FEIELNAGYKLISQTFKD--------------HEKCGIKE- -----ILLVP---KPF----------------------------------------------------VCMA VSKT-S-S-------------------------YREIFAQ-----------RLVWQQETGMFDR-------T IKKWSD-------------------------------EKP-----------------KC--NM--------- --------------------DRATFISVGYNEINSIFIIFL-------------YGLII-SII----IFFLE IFL--------------------------------F-------------KINN------------------- ------------------------------------------------------------------------ -------------------------------------MSRK------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------KTA---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PhumIR75t/1-477 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------M---------------K------------------ --------------------------------------------N--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------KIDK--------------------- ---------------------IS--VVSPYKTI---------KTRNLI-----------------------T EILAEGT-------------------------------------------------------PK-------- ------------------------------------------------------------------------ ------------------------KGLIMFNNKM------------------LA--IRRWN----------- ----------LQGIT-IRSSFV-------------------------------------------------- -----------------I---------------------------------------T-DL-------NSL- ---------------------------------------KHL------------------------------ ------------DDFV--------------------------------------DKHIDTTSKLA-H----- ------------AAINLLKT-L----------------------F----N----------I----------- ------------S----IEFKI------------QDA-WGTPQ----------------------------- -------------------------------KNN---------------T---W------------------ SG------------------------MIG---DL--------------QR-K--------------E---VE IGGS-----------------------------------------------------------PVFFQ---- -KSR---LDI--I-----------EY-FGFM-----TPTR----IAF-------------I-LIS------- --------------------------------PPLSHS-SN---------------IFTLP---FA------ ----------------------------------QTV--W-FSC-FGL-------FT-L---GC-----FLL FFSINKEFTQEYLENS-------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------------NEPKKKIT------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------LSD-----IVVY---NVG--------AIC-----QQG- ---------TAAE-TQHPSSRIITLF------IYL-----AYMFLYISYSA-----SI-----VA-ILQSSD ---K------------------------SIQ-----TLSDLFNSYLE------------------------- -----------VGAD----------NVSYSQ--------------YYF----K------------------- -------------S----------------------------------AN-DT--------FRKKF------ -YKV-KMA--------SKKN-------------------------------------SNFMSPEV--G---- VEKIR----------H-G-------Y-F-A-FQTEVPVGYQLIQKTFNE--------------NEKCGLQE- -----SKAFFE--VGE----------------------------------------------------PGLV MKKH-S-P-------------------------YNELFRI-----------GTLKLVERGFKTR-------Y TKKYYV-------------------------------SKP-----------------ICGS----------- --------------------KSSRFFSIALVDCHQAFLTLV-------------WGMIT-AVT----IFFFE IL---------------------------------Y-DKF-------K-RHQN------------------- ------------------------------------------------------------------------ -------------------------------------KKKK------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------KTKK--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >QCO69764.1/1-801 IR93a [Amphibalanus improvisus] ------------------------------------------------------------------------ ------------------------------------------------------MPDV--NLLEALQDT--- ------------------------------------------------------------------LDQQ-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----VPQLQFTEV------ELVALPA-------DSGDGL--------------------------------- ------QIPP-DLNALF--VQSNCRDVSNIKKMIDDL---EISTIIFTG----------------------- --------------------------------------------------------------------AGCT P----------------------------VREGRMHQL-----------------PVFA-AA---------- --------------------QDLPE--------VFRELK--GSGTLR------WHEMN-------------- --------------------------------------IITY-SDA-------------------------- -----------------------DPVLLR--GIIDVLREGEQG---------------------DSALTVYS IPREQP-----TG-------PFGGPSSARDV-----------LRTIETQA-DHEG----------------- ------RQFLV-------FGD--RKSAH-------------------------------------------- -----------------------EIL-----------REA------------RAM---HLLV---------- -----PE-TQWLAV----------------------------------------------FWDTSQQ----- ------------------------------------------------------------------------ ----DTNMLQF----------------LPGV----------------------------------------- ---------RDGENLSFLF----NATRTGP---CPGNKT-----------CLLES-AALAL-L--------- ----AAMDEQHSDEWQLRVSVDED------------------------------------------------ -EWQ-ELQPSRGQRAHSYMTG---------------------------LRSGL------------------- -----------------------------------------------GSSERCP------------------ -----------------VCRQWTLQAAEI-------------------------------------GDYGKV SLLDVGRW-----------------------------------------------------LPGTG------ --------------------------------------------LHIADD---------------------- ---------------------------------------L------FPHV--------TGG----------- ----------FRGRT-IPIMSLE------------------------------------------------- ---------------------------------------------------------Y-PP--------WQI -----------------------------------------YK----------------------------- -----------RDS-R-------------GVV--------------------------YEYTGLI-F----- ------------EVVNELAQ-K----------------------L----N----------F----------- ------------S----YVVRA-PAD---------GL-WGI------------------------------- -----------------------------EESPG---------------K---W------------------ NG------------------------MIG---DI--------------LA-G--------------R---AL LAAG-----------------------------------------------------------AFTVN---- -AAR---QSV--I-----------NY-T-VF-----IDRQP---YNL-------------L-TRR------- --------------------------------PDH-LT--RAL-------------LFLQP---FA------ ----------------------------------ADT--W-WCI-FTA-------VL-L---AG-----PVL WLINRN------------------------------------------------------------------ --------------------SYYY-R---------------------------------------------- ---------------------------------------Y-----------------YNIP----------- ------------------------------------------------------------------------ ----------------------------------SSKD-FF------------------------------- ---------------------------------SLKY-----CSWY---AYG--------AIL-----QQG- --------G-PRL-PKADSGRFVVGV------WWL-----FVLVVVTTYSG-----NL-----VA-VLTFPR I--NN-----------------------LIN-----SLDDLLAFH---------------------TDVT-- -----------WGIQG---------GTAIE---------------NYF----R------------------- -------------E----------------------------------SP-EP--------KFRKI------ -FEGAKIH---TED-----------------------------------------------TDGD--I---- LAMVR----------H-E-------Q-H-I-YIEWKTNLLFLMKEEFRR--------------TDRCY---- -----YSLGKEN-FFE-EY-------------------------------------------------VAMV VPPK-S-P-------------------------YLKKFNKE-----------ISKMLKAGFIQK-------- ---W---------------KADFW-------------PS-------------Q---DRCSSTAYGGA----- ----------------------GRQKKVDLEDMQGSFYLLL-------------LGLVV-GLV----SLLFE CC---------------------------------YR-N--------------------------------- ------------------------------------------------------------------------ ---------------------------------------TDFRRPQHSA----------------------- -------------------------------------------------R---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------EVVV--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------QHTFLE------------------------------ >ROT64365.1/1-450 Variant Ionotropic Glutamate Receptor [Penaeus vannamei] ------------------------------------------------------------------------ ------------------------------------------------------MTSLHMNVVIL------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------ACFLSAIAT--------------------------------------------- ---------R-------------------------------------------------------------- -----------------------------------------------------------------------T TSSPIDGS---------VSKGAGDDAISR--DPDGVAE---------------------------------- ----------------------IVA--------QVIQRHL-------------------------------- ------------------------GTCQLT--------LVTS-PSDK------------------------- --------------------SPLAVAFVR--RLSAT----------------------------FQGHMVIE AKTPL-------------------------------------KKSLSGFE-ETNPTRPC------------- ------LALLL------VAPE--SSVFT-------------------------------------------- ----------------------ETLA-----------PFL------------QNS---SLFL---------- ----CPE-CRVVVT----------------------------------------------GPRNAAL----- ------------------------------------------------------------------------ ----D------------------------TLLHP--------VF---------------------------- ---------RNTKHALYLT----PV----------------------------------------------- ------------------------------------------------------------------------ -------------DTATASTP---------------------------------V----------------- ---------------------------------------------CHSATSSFGISGK-------------- --------------GPGCATVLQGYSRCLYC-----------------------------------WA-GQA GMRTLGHW--------------------------------------------------KRNVGFS------- ------------------------------------------------------------------------ -------------------------------ENH---V-V------FPDK--------LED----------- ----------MNGHR-IRVVAKE------------------------------------------------- ----------L------------------------------------------------FP--------FVE -----------------------------------------HQ----------------------------- -----------PHSNA------------SA-------------------------TTVTPKDSLD-V----- ------------RI---------------------------------------------------------- -----------------YEVRM-AWD---------DQ-WGT------------------------------- -----------------------------LNN-G---------------V---W------------------ SG------------------------MVG---TL--------------EQ-E--------------R---AD FSLM------------------------------------------------------------LFWS---- -HSR---KQV--I-----------DF-T-RI-----YAYEP---FVM-------------I-THK------- --------------------------------PRP-LP--QHT-------------ALVRP---FRGSWAGL RWSLSRCLS-------------------------VEL--W-GAI-LAA-------TF-V---LA-----VSL WAIQRA------------------------------------------------------------------ -------------------WSSFS------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------GGRG---M------------------------------ ---------------------------------NINT-----AFLH---AWA--------ILL-----EDP- --------P-PRL-PSNFTG---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------AGEV---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >ROT65058.1/1-543 putative glutamate receptor ionotropic, delta-2 [Penaeus vannamei] ------------------------------------------------------MGD--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------SV ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------SG----AMA----------- ----------GNRTF-LRVAVEEVSE-----------------RKAWR------------------------ G--------KW------------------------------------------------GT--------WVR ----------------------------------------VQA-----G----------------------- -------------Q-D----------------------------------------GRLAITGPM-A----- ------------NILHVFAE-K----------------------M----N----------F----------- ------------D----YELVQ-PPD---------HV-WGV------------------------------- -----------------------------PLPDG---------------N---W------------------ TG------------------------MLG---ML--------------QR-Q--------------R---WS LPCGTFLSPLILKVLLILSILNLNLPHSLTLSILKGTPHTIHSEPESPPLPHTIHSEPESSPLPHTIH---- -SER---LSI--L-----------NL-N-LP-----HSLTL---SILKGGGVRPGPLRRDV-LARDC----- ---------------------------VRLLGPSQ-DG--ELGHLGDATGPAERRLGFLKP---FT------ ----------------------------------LPV--W-LLI-LAS-------VV-A---IF-----WAF AGV--------------------------------------------------------------------- ---------------------M-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------VAE GKLLRR----------------------SPRNPLSLS-----ALW----VVK--------ALT-----QEG- --------T-EWL-PRTDGARVVVAT------WLL-----ASLVFMSSYSG-----IL-----TA-MLTVPR V--DI-----------------------PID-----SMRDLVTQ----------------------TDIP-- -----------WRLES---------GSWML---------------QYF----Q------------------- -------------E----------------------------------AP-DG--------VRQSI------ -YDG-------------HTG-------------------------------------TFPDCWAA--R---- -EPIS----------R-G-------E-Y-A-ALCDHTTMKKAMSWDFST--------------SGSCH---- -----LYISREV-IHS-FN-------------------------------------------------LAVA FRTA-S-P-------------------------YKEDGDYW-----------IQKLKESGILDM-------- ---W---------------LQNEI-------------VN-------------T---SQCLKPPSSDRSTQD- ------------------------ISALDLESFFGPMLVLV-------------AGLCF-ALA----AIIVE AA---------------------------------VS-SF-------R-G---------------------- ------------------------------------------------------------------------ ----------------------------------------QS------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------SGD------------------------------- ------------------------------------------------------------------------ ---------------------------------------------------DEQHMARVGRAPF-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >ROT70491.1/1-345 olfactory ionotropic receptor IR8a [Penaeus vannamei] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------MVW------------------------------STNKMQMTP------------------ ------------------QLEFAITA------------------------------------------INSS TSVAVGTW--------------------------------------------------ASSSL--------- ------------------------------------------------------------------------ ---------------------------LTLNPNY------------------------EHS----------- ----------PIRRF-FRIGTVM------------------------------------------------- ---------------------------------------------------------A-RP--------WVY ------------------------------------------------KKEGG------------------- ------GAAA--------------------------------------------------YEGYC-V----- ------------ELSKKLSE-L----------------------M----T----------F----------- ------------D----FEFVF-PAD---------GH-YGA------------------------------- -----------------------------RQKNG---------------S---W------------------ NG------------------------LVG---DL--------------AN-G--------------N---TD IIVA-----------------------------------------------------------PLTMT---- -SER---EEV--I-----------DF-V-APY----FDQSG---ISI-------------V-IRK------- --------------------------------RQR-QE--NLFK-------------FMTV---LK------ ----------------------------------AEV--W-VSI-VAA-------LV-V---TG-----IMI WLLDKY------------------------------------------------------------------ --------------------SPYS-AQN-------------------------------------------- -----N------------------------------AALY-----------------P-------------- ------------------------------------------------------------------------ ----------------------------------PNCR-IF------------------------------- ---------------------------------TLKE-----SFWF---ALT--------SFT-----PQG- --------GGEA--PKALSGRTLVAA------YWL-----FVVLMLATFTA-----NL-----AA-FLTVER M--QT-----------------------PVS-----SLEELAGQS----------------------KIN-- -----------YTVLK---------STATG---------------QYF----Q------------------- -------------NMAAAEEELYRL-VDSSLS---TT--------------------------THI------ ------------P----------------------------------------------T------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------TTLHA---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------RPS-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------LPMRL---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >ROT71107.1/1-422 olfactory ionotropic receptor IR4 [Penaeus vannamei] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------MQ-----FKF----------- ----------SRAPH-FKVAAEE------------------------------------------------- ----------W------------------------------------------------PP--------HVY -----------------------------------------IH-----K----------------------- -------------G-E-------------G--------------------------NELIVKGPM-G----- ------------QLMDAIAA-S----------------------L----N----------F----------- ------------T----YSVV--PGD---------GY-WGA------------------------------- -----------------------------PQENG---------------T---W------------------ NG------------------------MIG---TV--------------MR-K-------------------- -------------------------------------------------------------------V---- -QTR---TSA--SVPSACPTPGARSS-T-SP-----VFLEM---LHV-------------L-VSR------- --------------------------------PLP-QP--DPW-------------GFLAP---FT------ ----------------------------------WYV--W-VGM-LVS-------IV-A---VM-----LTS A----------------------------------------------------------------------- -------------------------LVV-------------------------------------------- -----RAL-------------------------------G-----------------QGGP----------- ------------------------------------------------------------------------ ----------------------------------A------------------------------------- ---------------------------------SLAH-----HIWA---YYS--------ITF-----SQS- --------L-PWV-PGGDSLRVVVWT------WMI-----IMLVFMRSYSG-----AL-----TS-LLAVKT I--EL-----------------------KYD-----SLQDVLDD----------------------KGLT-- -----------LIMEG---------STALT---------------THL----K------------------- -------------T----------------------------------VS-EG--------VYKEL------ -AEA-SRV---RAKYVRASE-------------------------------------MDVAAYN-------- --YLP----------D-G-------R-H-A-ILVEEVVCRKIYSDHFSR--------------TGKCS---- -----FYMSTGN-FWR-LI-------------------------------------------------YAMI VRPK-S-P-------------------------LRELINAR-----------ILALREFGIYDR-------- ---W---------------AGDQM-------------PN-------------M---THCLKTPTRIKLHAP- ---------------------------YSLADLWAVFLLLG-------------AGTTL-AAV----VFLCE AS---------------------------------FR-RG-------G-SC--------------------- ------------------------------------------------------------------------ ----------------------------------------N------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------DPDL---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >ROT73751.1/1-517 Variant Ionotropic Glutamate Receptor [Penaeus vannamei] ------------------------------------------------------------------------ ------------------------------------------------------------MTWVA------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------SPTAVP----------------------------------------------- -----------RLPLSL--SWFL------------------ASFLALG------------------------ -----------------------------------------------------------------------S GTGLAQSQ----------TEAAGS----------QVGQ---------------------------------- ----------------------LLR--------QVVEEKL-------------------------------- ------------------------MECHLV--------ALGD-TNAP------------------------- --------------------ASIMATLLR--HLSESG---------------------------YPSRTVVD VTK---------------------LEESREF-----------YDLLMKDL-KGLGMLNC------------- ------RAFLI------DVTP--LQSQP-------------------------------------------- ------------------------LL-----------RFL------------EDI---ELYK---------- ----KSE-TYVLLV----------------------------------------------GPNDRAA----- ------------------------------------------------------------------------ ----D------------------------FLSHP--------AF---------------------------- ---------RNTANILYFG---------------------------------------HHL----------- --------------------------------RP-------------------------------------- ----------ASKDVLNLMSP---------------------------------Q----------------- ---------------------------------------------AQSAKGTRTRSLRP------------- ------QFS--RSQFVQREQRIAAYTRCFYC-----------------------------------NN-GEE RRYIIDTW--------------------------------------------------TSHAGFT------- ------------------------------------------------------------------------ -------------------------------YSA---N-L------FPDQ--------FET----------- ----------FHGHR-FNVVAMN------------------------------------------------- ----------W------------------------------------------------FP--------FTK -----------------------------------------FI----------------------------- -----------QHSEE------------GG-------------------------TVVTPQDSLD-I----- ------------RMLNALAE-A----------------------L----N----------F----------- ------------T----YEMRT-PWD---------NQ-WGT------------------------------- -----------------------------SSPSG---------------N---W------------------ TG------------------------IVG---TL--------------QH-H--------------K---GD FSMM------------------------------------------------------------LSWM---- -EPR---LPI--V-----------DY-S-RI-----YASEP---LVM-------------V-TSK------- --------------------------------PKP-LS--QAF-------------ALVRP---FAGYDVSS R-TRDRIVKTSPIFLHQPNNLTTTNTIISLSP--GSL--W-FVT-LAS-------TL-A---AG-----LVL WLLQLW------------------------------------------------------------------ -------------------WAKMS------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------GGEK---L------------------------------ ---------------------------------EFGD-----ATLM---TWG--------ILL-----EDP- --------P-VNI-PRNVTAQV---------------------------RS--------------------- ------------------------------------------------------------------------ ------------GASC---------SAGAG------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------SLGR-------- ---W-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------GRGS---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >ROT78691.1/1-232 Variant Ionotropic Glutamate Receptor, partial [Penaeus vannamei] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------T-EAR-XDVLTAGCVAGT------WMV-----VSLILSSAYQS-----IL-----TS-LLAVPK V--EV-----------------------PVD-----SLQDLLDY----------------------GKIP-- -----------WSVEH---------GTSIH---------------QLL----D------------------- -------------D----------------------------------SS-AD--------VYKKI------ -NKK--------------IF-------------------------------------YVSSSFAE--R---- -DRMK----------E-E-------R-F-A-ILCDFFSMKLIMSDDYGQ--------------TGECN---- -----YYIAKEV-IWS-AA-------------------------------------------------MAFA FPKG-S-H-------------------------ITAHFNKW-----------MVMMKESGLVDR-------- ---Y---------------LQEVT-------------KN-------------V---TACMVPPGQEAGRNT- ------------------------SSFLSIFDLGGVFLIAA-------------GGAIV-SIF----VFLME KL---------------------------------SR-HR-------P-F---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >ROT82197.1/1-484 olfactory ionotropic receptor IR7 [Penaeus vannamei] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------MS-----------SHTLAL----SRQTSAGV---R------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------AGNRHEKI----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------LQFG--------------------- -------------------DGGE-------------------------------------------QVR-E- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------AAP-----------------GSG----NSL----------- ----------LEGRT-LRVAAEE------------------------------------------------- ----------W------------------------------------------------VP--------HIA -----------------------------------------VR-----E----------------------- -------------D-R-------------G--------------------------GNISISGPM-A----- ------------NLLHALSS-A----------------------L----G----------F----------- ------------S----YTLVR-PPD---------GA-WGI------------------------------- -----------------------------PTEAG---------------D---W------------------ NG------------------------MIG---MV--------------KR-NPPPPLTSGHVVSLVE---AD LALG-----------------------------------------------------------PFGLT---- -YSR---SRV--V-----------DF-S-SP-----ILIDY---YRI-------------L-TKR------- --------------------------------PRS-EP--NPK-------------GFLTP---FR------ ----------------------------------WHV--W-IGL-VLS-------VG-V---IG-----AVL FGV--------------------------------------------------------------------- ---------------------R---KAA-------------------------------------------- -----HTF-------------------------------F-----------------GGEE----------- ------------------------------------------------------------------------ ----------------------------------MHAS-----------------KNA-------------- ---------------------------------SLPQ-----HLWA---TYG--------ALI-----SQP- --------Y-TWL-SRSWSGRVVVGM------WSL-----AALIVARSYSS-----AL-----TS-MLAVRT V--PV-----------------------KYN-----YLRQVIGD----------------------PDIH-- -----------LIFEK---------ATALV---------------EHM----S------------------- -------------T----------------------------------VQ-EG--------VYKDL------ -ANTIQQD---RAHFLASSK-------------------------------------LYDAAYT-------- --DVR----------N-R-------Q-F-A-LLVEDTTCRKVFSDDFTK--------------YGRCD---- -----FYIGKER-YWP-LV-------------------------------------------------FCLI GRKG-M-P-------------------------IMQAINSR-----------IERLVSHDLYFK-------- ---W---------------LEDEL-------------PN-------------A---TACLKASTKITVNEA- ---------------------------YDLTGLWGVFVLFL-------------GGLVV-ASL----VLMTE VC---------------------------------VA-VV-------A-DW--------------------- ------------------------------------------------------------------------ ----------------------------------------M------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >ROT85209.1/1-499 putative chemosensory ionotropic receptor IR68a [Penaeus vannamei] ------------------------------------------------------MISRDG------------ -----------------------------------------------------VCLLLVGLTFAASQSPGDV RRL------LG------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------AGRQLRALGR ------------------------------------------------------------------------ ----------------------------------------------------SA------------------ ----------------------------DEDARRSVFLTDPR-------------PLV-------------- ------------------------------LAQVIREMGG-------------------------------- ---------------------GDRGLCHVL--------IYYD------------------------------ -------------------PETAPPEAVD--ALRKAV---------------------------DVPLTLVD VSKLRFPLITKTR-------------------------RR--VPLLDLLS-ARADGR-CRLLVGWA------ -SSNYQRGLLL-------IAR-AEPGVL-------------------------------------------- -------------------GLRDTLILP--------VSSQ------------------RLDRF--------- ----MPQLRQRVLVKERRSRGG--------------------------RGR--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------RELQPTRFLV----------------------------------------------------- ------------------------------------------------------------ERTCE------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------TCARYS------------------------------------------------- -LRRLGEW---------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------Q--------FPGG-WEWGGVAERN----------- --------PKLTGVE-LTVAYTP------------------------------------------------- ---------------------------------------------------------S-VPN------IFWV ------------------------------------------------------------------------ ---------------S-------------GD-------------------------GRPRLEGVE-L----- ------------RLLDYAAQ-A----------------------L----N----------F----------- ------------T----YRLVV-PED---------GE-WGRPL----------------------------- --------------------------------NG---------------S---W------------------ TG------------------------KVG---EV--------------VY-G--------------R---AD VAVG-----------------------------------------------------------GLVFT---- -AER---EAA--A-----------KY-S------ILFHNEL---WGI-------------V----------- C-------------------------------PLS-AR-LPVWP------------YVMFP---FR------ ----------------------EDSA--------PSV--FTMLV-----------VL-----------HVMA YLVGTLL----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------G----------------------AHAG---------------------------------- ---------------------------------AAPQH---------------------------------- --------------PLTESVTRAVRTG-----VSL-----YLRLMACLYFW-----NLFY------CLMKPK Y--EP-----------------------PID-----SSLALLRSA--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------AAGASSAA----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---PPS-----PP-----SCRRRS------------------------------------------------ --------------------------------------------------RWRTRTWPPTLC---------- --------PSAP---------------------SAKAS---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >ROT85317.1/1-390 Variant Ionotropic Glutamate Receptor [Penaeus vannamei] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------MS----------- ----------LSGRH-LAVGADV------------------------------------------------- ----------W------------------------------------------------SP--------WV- ------------------------------------------------------------------------ -------------E-M-------------E--------------------------GEDSWSGIA-V----- ------------AVFAILAK-K----------------------M----N----------F----------- ------------T----YHYVR-PLD---------HE-WGR------------------------------- -----------------------------KLPNG---------------S---F------------------ TG------------------------LVG---LL--------------ER-R--------------E---VD LALG-----------------------------------------------------------PLSIS---- -WDR---FQV--A-----------DF-S-TF-----LYMDW---WGV-------------L-LPR------- --------------------------------PRM-ER--DFA-------------GFLKP---FA------ ----------------------------------PEV--W-LGF-GAS-------LL-V---TI-----ILG VIL--------------------------------------------------------------------- ------------------------------------------------------------------------ -----RAL---------------------------------------------------TP----------- ------------------------------------------------------------------------ ----------------------------------ASLP-----------------DI--------------- --------------------------------KSSFN-----MAW----IAR--------TVM-----NEA- --------T-ESL-PLSLSGRAFLGT------WML-----AMFVITSAYSG-----VL-----TS-LLTVQS I--TV-----------------------PVD-----SVEDLVSY----------------------GKIP-- -----------WNLER---------GTWMH---------------GRY----A------------------- -------------R----------------------------------SN-ST--------LGRKI------ -YGG--------------AG-------------------------------------IVSSAWDI--R---- -ECIK----------R-E-------R-E-A-VLTDHFNMMKIMHHDYME--------------TGQCN---- -----YYIGKVP-LAS-SL-------------------------------------------------LAMA FPKG-S-S-------------------------LVPDFNKW-----------LTSLVETGQVTQ-------- ---L---------------MLNLT-------------SN-------------A---KACMARPGKENKSNT- ------------------------PLVLTLDDLGGVFFLLV-------------GVSS-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >ROT85324.1/1-885 putative glutamate receptor ionotropic, delta-1-like [Penaeus vannamei] ------------------------------------------------------MSDPP----DRTNDVLDI S----------------------------------------------------QFLNVYVSVDEDPQAEPLE SWEDDPLRDTGVQEEERATWINEQGNSSIQA-----------P-VAHLRQRLAPGMANKKSRDGQ---KQPE DLY-------------------------------------HSDMYSS-----------------------CA HT------------DMYVCPKSPLG----------------------------------------------- ---SGSQTLLSDATVDPQSNALVSSK-------RLTHTHARNMGREGGG---------SARRKGLRKGGWRG --GQQLCLASVDRVTLL--ST-------------AAR--PEALGQSQDAGSAPT------------------ --------------------------------------------------------------------PDGS RPFSCRGNRSRGLAEVLLRRMGSDPFPSEGGRSSEMER-----------------PS---AKWSGQ------ ---------------EPRILADLLP--------FLVTS---TTAR----------QIL-------------- --------------------------------------LIHD-LSA-------------------------- --------------------PNISP-AIR--AV----YEQWYG------------------------VTTIS F--------------------------QSAA-----------DFLDFIVK-ALSNVSEK------------- ------RIAIV-------ICS--GGNTV-------------------------------------------- -----------------------AIF-----------EAI------------REK---DLES---------- -----PK-IQWF-V----------------------------------------------VMRENLT----- ------------------------------------------------------------------------ ----FDLTAA--------------------L----------------------------------------- ---------REGTQITLAA----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------QTSS--------------------- -------------------NSYRLSTSYV-------------------------------------DVKNKI GLAYAGHV---------------------------------------------------------------- ---------------------------------------------TWNDE-TGKMT---------------- ----------------------------PFLASP-----L------TPDL-ERV----YAD----------- ----------FGGRQ-LKGAVVP------------------------------------------------- ---------NW-------------------------------------------------P--------FFQ -----------------------------------------VT-----PL---------------------- -----------DAY-D-------------GPY-----------------------QEAGPVSGID-F----- ------------LVIDAIAT-E----------------------L----N----------F----------- ------------T----YKLLV-A-----------DS-WGG------------------------------- -----------------------------PQPDGR--------------S---I------------------ TG------------------------MIG---MV--------------AR-R--------------E---VE FAVD-----------------------------------------------------------EITIT---- -GAR---EAV--L-----------DF-S-QP-----YFMES---ITI-------------V-SRA------- --------------------------------PAE-KS--RAV-------------AVFSP---FTPAVPST PWA------------------------VHVVPQDSKV--W-AAL-VLS-------VA-V---IG-----PLL AAV--------------------------------------------------------------------- ---------------------NHL-TSF-------------------------------------------- ---------------------------------------Y-----------------LGGK----------- ------------------------------------------------------------------------ ----------------------------------DHF----------------------------------- ---------------------------------SSRE-----FAFN---MFR--------NLV-----VQG- --------N-LIS-SARWPLRCVFFS------WYL-----FCFYVCALYSG-----TL-----TA-VLAIPA F--EK-----------------------PID-----SLADLLRAMKE------------------DGFSP-- -----------LFIYD---------TSNVH----------------IL----K------------------- -------------E----------------------------------AT-SG--------IYKEI------ -WDRF-----------QPDS-------------------------------------GYVFSANE--G---- VDKVL----------T-G-------K-F-G-FVNAWLASEIRI----TA--------------RGKEN---- -----YHLARQT-YYP-QS-------------------------------------------------YGVA LQSG-A-P-------------------------YLAVFDKK-----------LAQLVESGLIGK-------- ---W---------------RRDVV-------------GS-------------A---AGRVPDE--------- -------------------GPQGGPGAVTLIHLQAAFFVLA-------------VGLLA-ASL----ALGFE VG---------------------------------FC-RR-------R-RRRRRV----------------- ----------------------------------------------G------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------KAPGISSSV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >RWS04344.1/1-668 glutamate receptor ionotropic: kainate 2-like protein [Dinothrombium tinctorium] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------MC------------------------------------------------ ------------------------------------------------------------------------ -------------------------TRETKNYT--------------------------------------- -------------------TDVF------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------KFT-----------RLI-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------AYFYY----D--------------------------LMRL--TLESV-H--------- ----NT--PTM-------------------------------------------WVSDDAQLSCQK------ -LEF-QMLSQKDCGSNNLRNQ---------------------------LEQSSHE----------------- -----IFGKFGEFVVKL----------------------------DGSLESYQR------------------ -------------------ITMKINEQSYL--------------------------------------YQKM KLRQIAEW--------------------------------------------------EYDEE-GGT----- --------------------------------------------LFTR---ALDEDEEN------------- ----------------------------NDDE-E------------------------EGK----------- ----------KSGLI-IQLIM--------------------------------------------------- ---------------------------------------------------------H-PP--------FVM ------------------------------------------------------------------------ --------KLVKNS-T-------------GETQE----------------------QKVEYYGFV-I----- ------------DLFQLIVK-E----------------------IPDFPK----------Y----------- ------------T----LEEYE-AEDE--IAI--YGH-YGTGK----------------------------- -----------------------------ENKMGGGDD-QNERT-----D---W------------------ KG------------------------AIT---RF--------------DE-K--------------T---QM ISLG-----------------------------------------------------------AWTRT---- -VER---ENK--T-----------DF-T-EPF----FELVG---NTV-------------V-MKK------- --------------------------------PLR-HI--YYWK-------------FINV---LE------ ----------------------------------DNV--W-YCI-ISA-------YF-L---TS-----VLL AIFDRY------------------------------------------------------------------ --------------------SPYS-YQN-------------------------------------------- -----N------------------------------KLKY-----------------KDD------------ ------------------------------------------------------------------------ ----------------------------------DEKR-IF------------------------------- ---------------------------------TLKE-----SMWF---CIT--------SLT-----PQG- --------GGEA--PKSLSGRLVAAT------WWL-----FGFIVVASYSA-----NL-----AA-FLTVSR I--DN-----------------------RVE-----DMEKLAHQY----------------------KVR-- -----------YGPVM---------GSALQ---------------TYF----N------------------- -------------RLALVEEKFYEVWKDMSLNDSLSEDERAKLAIWDYPI-SD--------RSTKI------ -WSQVKEP---DSM---------------------------------------------PKSYEA--G---- LAAMKSSKTH-----K-E-------G-F-A-LVADSLTVDY--------------------FAFTHCD---- -----VYRIGTE-FSP-RP-------------------------------------------------MSLA ISKNLR-P-------------------------LKKKIDEA-----------IIKFRNDRTIEK-------- ---L---------------KGKWW-------------DW-------------NPLRQECEDWRLL------- ------------------------SNGISLQNAGGTFIVYI-------------AGVCS-CFF----AIAVE NH---------------------------------FI-KR-------M-IVRDF------------------ ------------------------------------------------------------------------ -----------------------------------KDMQSGKKRREASS----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------NSN---NRRLR-------LF------ ------------------------------------------------CWRKKNR----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >RWS13744.1/1-877 glutamate receptor: ionotropic kainate 3-like protein 1 [Dinothrombium tinctorium] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------MSCERSKSLYQLVRDH-CPSTLLLAVHG----------------------- --------------------------------------------------------------------RQCV RPFH----------------------------DQGIGF-----------------PLMT------------- ------------------SVNDVVS--------MLIDMKY--------DFLKNWDHIS-------------- --------------------------------------LIHD-RSLD------------------------- ------------------------ANSLQ--DLVNGLISIYGP------------------GIQQSTVTTYR VDDTKSSSKKALK--------GTFYKANDQLM---------LVRKGSSFKFADIAAHLS------------- ---DEQSKYFI-------LVS--KGHII--------------------E----------------------- -----------------------EVI-----------EKA------------YNN---SLMDY-P------- --------KKWLVIFTNVIRRKRFWN---------------------------KMRPLFAITDTSVV----- ------------------------------------------------------------------------ ----QREISEYGQ--------------CREL----------------------------------------- ---------KEGCQLRLAF-------------------------------EVLKE-AMVKV-SLNP------ ------------------------------------------------------------------------ -DYDLTDLDTKKQTKNRLLAE---------------------------IRLLLGT----------------- ---------------------------------------------EETVAQHCG------------------ -----------------NCDRFVLQVYEKHKR----------------------------------SKKVKQ ESLPVRTW---------TE---------------------------------------SPNSDEKYE----- --------------------------------------------VKITHS---------------------- ---------------------GEWTPFKGLLKQN---E-L------FSKK-FE-----GGN----------- ----------LGGRT-LTVGIIN------------------------------------------------- ---------------------------------------------------------Q-PP--------MIR -----------------------------------------VQI---------------------------- ---------------E------------EG--------------------------GKCNVSGVT-P----- ------------EIVEILAS-R----------------------M----N----------F----------S IKWWC-------S----KEVYQ----------------LGILK----------------------------- --------------------------------DG---------------K---W------------------ TG------------------------LLG---KL--------------VS-K--------------D---ID IAAN-----------------------------------------------------------AYWQT---- -------WQM--I------SSNQFTF-T-TP-----YDIEN---VGI-------------I-VKK------- ----------------------------SI------ED--HSF-------------LFVCP---FT------ ----------------------------------IEV--W-FFA-MTS-------FA-C---VG-----PLL WFVQKY------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------S--------------------------- ------------------------------------------------------------------------ ---------------------------------------LFY------------------------------ ------------DYY------------------NMRD-----------------------AML-----QQG- --------G-TFL-PQGIPARVIIAY------WWF-----YVIATVTLYSG-----NM-----VA-LLTFPK I--VQ-----------------------PVE-----NAQDLLDS----------------------WFMS-- -----------WGTIK---------DDPIQVM-----------ANELL----Y------------------- -------------G-----------------------------PLKDLAP-KM--------KYYDM------ ---------------------------------------------------------------------PQQ LEYVLHA--------A-S------WE-FFG-FIAREQEARMWISQKYYE--------------EDYCS---- -----LYFGRDP-VLY-MP-------------------------------------------------MSIV LRKD-I-P-------------KG----------MIDQINEE-----------MYIMKRSGLPQY-------- ---W---------------KIRYQ------------EPG-----------------NDCM------------ ---------------YPFIIHAGDVKKVQIKHLFGSFLILS-------------VGLIC-SVV----ALVIE AF---------------------------------HFTKH-------R-KRLPQPVGMSLWQ---------- -------------------KLRSW---------YLK-------ITKGALW---------------------A DWVESE-------------------RSPLTVKGKAGDMTFMTPRPLGSNPKSG------------------- ------------------------------------------------------------------------ --------------------------------------------------WVNGQTPKIFSTTY-GMQ---- -----YSTVYGNPTSTIYNTKANF------------------------------------------------ ------------------------------------------------------------------------ --------------------NYF-------------------------SYNPSKNTKSTFATKP-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >RWS30328.1/1-910 glutamate receptor ionotropic: kainate 2-like protein, partial [Leptotrombidium deliense] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------LTIDENSD--------------------------------------- ----------------YLANGIYKAV-----------KEHNSTHFN----------------T-ITLRK--- -----VIVNETTDEA------LICSAIFEN------DIKPSMII---------------------------- ---------------------------------------------------------------------DVT NKRWP-------------------ATVEIRNLARKLKI-----------------ATVSTNSATKQD---WQ YLSMKENQWLLNF---KSPTNVFIH--------AVEDI---VHF-FG------YNKF--------------- -----------------------------V--------VLHD-HTFD------------------------- ---------------------------TD--ELKSMFAGNE-----------------------TLQIMFKS LEND-------------------NISEFETL-----------VRSLRKKRKENLTN---------------- --------FFV-------LAK--PMTIN-------------------------------------------- -----------------------KFM-----------EAI------------TFN---DMFR---------- ----ITN--NWYFL----------------------------------------------TKG--------- ----------------------------------KGKLRCIS--------CLHATANVIQPV---------- ------------------------------------------------------------------------ -------------DAYFYY----D--------------------------LTRL--ILKSV-E--------- ----RSYEAVT-------------------------------------------WIPLKHLESCKN------ -IES-HSSRLKHFEGVNLRKS---------------------------MEEEVED----------------- -----FHGKFGEFVVNC----------------------------EGSLESYQS------------------ -------------------VTLRLSRQVY---------------------------------------RRDM KSRKIAEW--------------------------------------------------EYSEP-SGN----- --------------------------------------------LFFT---SADEDGDG------------- ----------------------------EDKPLE------------------------EIP----------- ----------EDGIL-IQVILVCNYL---------------------------------------------- -----------------------------------------------------VLTNH-PP--------FVM ------------------------------------------------------------------------ --------KYTENS-T-------------DGTQK----------------------QTVSYYGFL-I----- ------------DLLEYIKA-E----------------------IPTFPK----------Y----------- ------------I----IREHS-SGD----GL--YGH-YKTGKD--KN------------------------ ----------------------------EENADGSGGE-EDDGEGGVGLP---W------------------ KG------------------------AIK---EI--------------YK-L--------------K---RV LSLG-----------------------------------------------------------AWTRT---- -YER---ENL--T-----------DF-T-EPF----FEMVG---LNV-------------L-MKK------- --------------------------------QKR-HI--FYYK-------------FVSV---LE------ ----------------------------------GSV--W-LCI-TGA-------YF-I---TS-----ILL TLFDKY------------------------------------------------------------------ --------------------SPYS-YQN-------------------------------------------- -----N------------------------------KLKY-----------------KDD------------ ------------------------------------------------------------------------ ----------------------------------NEKR-IF------------------------------- ---------------------------------TFKE-----SLWF---CMT--------SLT-----PQG- --------GGEA--PKSLSGRLVAAT------WWL-----FSFIVVASYSA-----NL-----AA-FLTVSR I--DN-----------------------RVT-----SFYKLTKQY----------------------KVR-- -----------YAPIA---------LSAVE---------------TYF----N------------------- -------------RLAMVEEKFYEVWKDMSLNDSLTEDERAQLAIWDYPI-SD--------RFTKI------ -WAQVTEA---KA----------------------------------------------PKSFEE--A---- LSRVKNSQDH-----K-E-------G-F-A-LITDSLTVDY--------------------FTFTHCD---- -----VTKVGLD-FSP-RP-------------------------------------------------LSLA IGKELK-D-------------------------LKALIDAA-----------IIKLRNNRTIAN-------- ---L---------------KGKWW-------------DW-------------NELRQDCEDQRRL------- ------------------------SNGISLRNAGGTFIVFI-------------AGVCA-TLF----AVAVE NI---------------------------------CI-KA-------M-IIRDF------------------ ------------------------------------------------------------------------ -----------------------------------KELQFG--RREEPT----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------VRRFRGFNCNWLSF------ ------------------------------------------------CCRKKNR----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >RXG52209.1/1-217 Glutamate receptor, partial [Armadillidium vulgare] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------E---AD FALG-----------------------------------------------------------PFGLT---- -DSR---SKI--V-----------EF-S-TP-----ILIDY---YRI-------------L-VKR------- --------------------------------PNL-QR--DPW-------------VFLNP---FS------ ----------------------------------FDA--W-IGL-IIN-------MV-F---II-----ISL TVI--------------------------------------------------------------------- ---------------------FIT-FEN-------------------------------------------- -----KIL-------------------------------V-----------------KKSK----------- ------------------------------------------------------------------------ ----------------------------------NLQN-----------------TSRLS------------ ----------------------------SYSKNIFSR-----QIWS---VFG--------TLI-----GQP- --------Y-PLT-LNSYSGRITIII------WLM-----CFVVLSKTYSS-----TL-----TS-LLAVRS L--DP-----------------------KYN-----SLNDLVKD----------------------KEMH-- -----------LVFEK---------ATALV---------------EYL----S------------------- -------------V----------------------------------SN-LN--------LH--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------LL TRKY-P-P-------------------------IRPIAATG-----------IEH----------------- ----------------------------------------------------------------KI------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >SmarIR25a/1-846 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---MQ------------------------------------------------------------------- ------------------------------------------------------------------------ ---------------KQASPGLAAAG-----------QYMRNFQQ-------------------FSVR---- --FSRIIVEE--DINST--LERICHELSTSSLTE--TPPTVVII---------------------------- ---------------------------------------------------------------------DIS QSGL--------------------ALSAINLLKEKINI-----------------PIVFSSLN-DGNFK--- -----PEENQLHV---LPPNRIIST--------ILRDF---ILI-QK------VQGVL-------------- -------------------------PLSLN--------VIHD-ETFV------------------------- ---------------------------FL--N-----LTNC-----------------------TIYQLAMD ---------------------------KNAI-----------EHKLISIQSWE-TA---------------- --------IIL-------IGS--FSFIN-------------------------------------------- -----------------------AIL-----------EVV------------SEH---NIFK---------- ----TVS--TLYAF----------------------------------------------SPEGEL------ ---------------------------------THLQKPCN----------SSYSLVILNAEIY-------- ----NKTR--LDELKLQHSELAT----SPQV----------------------------------------- -------------DTLFYF----H--------------------------ISVA--SLLAS-F--------- ----NFINTSQIKQLI-------------------------------------------------------- -SFK-NMSTKSSHELLNLIKE--------------------------------------------------- -KIIFLPSPYGPFYLKN------------------------------------------------------- ---------------SEIQQNFTIQATKLIN-------------------------------------KNHC KKNQFSSK--------------------------------------------------IKPSE--------- ------------------------------------------------------------------------ ----------------------------FEVSSL------------------------EKS----------- ----------TTE---YRIVVAEF------------------------------------------------ -----------------------------------------------------------PP--------FIY ------------------------------------------------------------------------ ----------EDNS-K-------------KP---------------------------KKFYGYC-I----- ------------DLLNHLSR-R----------------------L----K----------F----------- ------------N----YTLYE-STF---------GN-LPE------------------------------- -----------------------------INKNH---------------T---W------------------ TG------------------------VIK---EL--------------IE-K--------------R---AD LALA-----------------------------------------------------------PVSVM---- -KER---QNV--V-----------DL-T-IPI----YDIVG---ITI-------------L-LRR------- --------------------------------PST-AS--SFFQ-------------FLTV---LE------ ----------------------------------KKV--W-GCI-LAA-------YF-L---TS-----LLL CLFDRL------------------------------------------------------------------ --------------------SPYS-SQN-------------------------------------------- -----H------------------------------KKKH-----------------VNDD----------- ------------------------------------------------------------------------ ----------------------------------KDHH-EF------------------------------- ---------------------------------TLKE-----SLWF---CVI--------SLT-----PLG- --------GGEA--PKNVSGKLMVAT------WWL-----FGFIVVASYSA-----NL-----AA-YLTVTR H--DK-----------------------SIS-----SLDDLFLQH----------------------KIK-- -----------YAPIN---------GSVAM---------------VYF----E------------------- -------------RMAYIENKFQKLWTEMNVK-EFDAEEKARLAVWEYPL-SN--------KYTKL------ -WINMKKT---KL----------------------------------------------PRTFKD--G---- LQRVRD-----------G-------D-F-A-LLAESTELKY--------------------ESITNCD---- -----VMTVGEE-FSR-KP-------------------------------------------------YALA VQKG-S-P-------------------------LKRQLSLE-----------ILKLETERVLHD-------- ---L---------------KQKWW-------------DK-------------NKNRKTCDVQE--------- ------------------------YGGISIKNNGGVFVVVL-------------IGLGL-GGL----TLLVE YW---------------------------------RC-QY-------R-TTRNK------------------ ------------------------------------------------------------------------ -----------------------------------HPARVNVISVRS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------QRL---KYRSAILK------------ ---------------------------------------------------KHPQIRPRYTYYYQT------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >SmarIR8a/1-572 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------LCCQFLSKSGTTCS---------CQPLI----------------- ------------------------------N----------------------------------------- -----------EDFTRRSF----D--------------------------------LIAKV-F--------- ----VAIKKGG-------------------------------------------SKIISIASDCT------- -SKN-EVAKPSDNTYANNLKT---------------------------ALA--------------------- --SFNDIVNLNNIL---------------------------------------------------------- ------------------QVNLELDI-----------------------------------------FTGSK PPEKMGVW--------------------------------------------------SSKQF--------- ------------------------------------------------------------------------ ---------------------------FKLDASQ------------------------EGK----------- ----------AILRH-FRVGVAI------------------------------------------------- ---------------------------------------------------------S-MP--------FTF ------------------------------------------------------------------------ ---------LKPSE-K-------------GE---------------------------KEIQGFC-I----- ------------RLLEKMAI-D----------------------M----N----------F----------- ------------T----YELVF-PTDN-------SGS-FGK------------------------------- -----------------------------KYPDG---------------G---W------------------ DG------------------------LIG---DL--------------VN-G--------------S---TH MIVA-----------------------------------------------------------ALTMT---- -SER---EEA--I-----------DF-V-APH----FEQTG---ISI-------------V-MKK------- --------------------------------AEK-EV--SLFK-------------FMSV---LD------ ----------------------------------PEV--W-WCI-LGA-------II-L---TA-----LVL WILDRF------------------------------------------------------------------ --------------------SPFS-GQN-------------------------------------------- -----K------------------------------K----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------S--------TLT-----TPG- --------NSHCHFSSNLSS---------------------CILVVCSFNAGHIYSQL-----GG-LFNSRK NAGKT-----------------------PVK-----SLEDLAKQS----------------------KIN-- -----------YTVVN---------NSATL---------------QYF----A------------------- -------------NMANAEDELYHT------------------VVWDYPV-KE--------QYGRI------ -FKVIKNS---GM----------------------------------------------FETTDD--G---- FKRVKTDRDG-----N-----------F-A-FIHDTAEVRY--------------------EVYSSCD---- -----LLEIGEP-FAE-QP-------------------------------------------------YAIA VQAG-S-P-------------------------LQEEISKE-----------LLDLQKDRYFET-------- ---L---------------VQEFW-------------NT-------------S-KKRECPNYED-------- ------------------------TEGINLQSLGGVFIATL-------------VGLTI-GML----TLVGE VF---------------------------------LA-KK-------K-DKNMV------------------ ------------------------------------------------------------------------ -----------------------------------KSIIT---EKQ-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------KSARI---------------- ------------------------------------------------------------------------ -----------------------------------------IEGIRTK------------------------ -------VIHPR----------------------PRL-AYRY------------------------------ >TcasIR21a/1-930 -----------------------------------------------------MQRGLI------------- -----------------------------------------------------VLK-LCLTALALKSL---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------DKRALQ-------------------KSHEKSQL------ --EKWEDKFLNRDPSF-DQTASLVN--------LISKVAL-------------------------------- ---------------------DELSGCSAT--------ILYD-KFTETS----------------------- -------------------SDLLLEKLFR--TFPIPYLHGQITDKYHM------------------------ --------------------------KVPKL--------------------QTSQD-TC------------- ------TGYIL------FLKD--VMRSK-------------------------------------------- -----------------------DVV----------GPQT------------NNKV--VLVSR-S------- --------SQWRVY---------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------EFLASE--------QS---------------------------- ---------QSFMNLLVIA----------------------------------------------------- ----KSEKI--------------------------------------------------------------- --------VSSSIARLIC------------------------------------------------------ ------------------------------------------------------------------------ -----------------------LALHLKFG-----------------------------------TALAIY AP---------------------------------------------------------------------- -------------------------------------------NGGKSA----------------------- ---------------------------------------V------YPSV-------I-------------- ---------------------AN------------------------------------------------- ---------------------------------------------------------V-PK--------LGF --------------------------------------RSA------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------ES-------------------------------------- --------------------------VTS---VI--------------TQ-N--------------G---AN LGIG-----------------------------------------------------------GLYIT---- -DTR--LKAT--------------DM-S-HI-----HSQDC---AAFIS-----------LASTA------- -------------------------------LPR--------YR------------AIMGP---FH------ ----------------------------------WTV--W-LSL-TLVY------LF-AIFPLAFSDKHTLR HLLDKP------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------E--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------EVEN-----MFWY---VFG--------TFTN-AFSFFG- --------KDSWSKTDKFATRLLIGF------YWI-----FTIIVTACYTG-----SI-----IA-FVTLPV F--PA-----------------------TVD-----TPEQLVRGKYT------------------VGTLD-- -------------------------KGGWQ---------------YWF----E------------------- -------------N----------------------------------ST-DP--------ITQKL------ ----------------LTRI-------------------------------------DFVPDIES--G---- LKNTTKAF----FW-----------P-Y-A-FLGSRAQLDYIVRTNFT-------------TINKRSL---- -----LHISSEC-FVP------------------------------------------FG--------VSII YNKN-A-L-------------------------YSKIIDQG-----------VLQAVQSGIVDKIKNDVE-- ---WET-------------MRSA--------------------------------SGKLLAANSYGKSLKA- --------------------LTVDDRALTLDDTQGMFLLLG-------------IGFLL-GGA----SLLSE WM---------------------------------GGCLHLCK---GN-RNQSATSIQSNYRSHEVPTPREK LDSMQFNSFENHKIEEEIVEERNC-IIHRQDDDDIEEHINRLFDFEGVFGEAN--------------PDSRT GPEEELSFKNTTKAFFSLYAFLDSRAQLDYIVRTYFTSMNKRSLLHISSECFVPFGVS----------IIYN KNALYSKIIDQGVLQAVQSGIVDK-----------IKN--DVEWETMRSASGKLLAANSYGKSLKALTVDDR ALTLDDTQGMFLLLGIGFLLGGASLLSEWMGGCLHLCK--------------GKRNQSATSIQS-NYRS--- ---------HEVPTPREK----LD-----------------------------------------------S MQFNS--------------------------------FENH-KIEEEIV---EERNCIIHRQ---------- -----------------------------------------------DDDDIEEHINRLFDFEG-------- ------------------------------------------------------------------------ -------------------------------------VFGEANPDSRTGPEEEL-------SEENG------ --------KK-------------------------------------------------------------- >TcasIR40a/1-680 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------MRRDHGGDLVSA----SFDIVAGFLF-------------------------------- ------------------------EEICIC--------FDKN-TNINF------------------------ ---------------------------LQ--HLLVRFVSN------------------------NIAIKLFN ITT--------------------------------------------------------------------- --VEVQDKYFA------FLN--YQVTNH-------------------------------------------- --------------------LGANTI------FFSSHKFY-----EHVLLEINER---DFIRR--------- -------NLIYIFN----------------------------------WGR--------------------- ------------------------------------------------------------------------ ------------------------RPFSRYFVRN--------II---------------------------- ----------NVMKVFVIT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------NPRNDTF-------------------- ----------------------RIFYNQ-------------------------------------AVPYKKH HLEMVNWW---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------Q-HGVGLFNHP-----T------LPAKYNNV----FKD----------- ----------FKENV-FKIPVIH------------------------------------------------- ---------------------------------------------------------K-PPW------HFVQ -----------------------------------YGN---------------------------------- ------------D-------------------------------------------------SIK-V----- ------TGGRDDRILSLLSK-K----------------------L----N----------F----------- ------------R----YDYFD-PPERI----------QGS------------------------------- ----------------------------SASENG---------------T---F------------------ KG------------------------VLG---LI--------------WK-R--------------Q---AE FFIG-----------------------------------------------------------DVALS---- -HER---ANY--V-----------EF-S--------FITLADS-GAF-------------I-THA------- --------------------------------PSK-LN--EAL-------------ALLRP---FQ------ ----------------------------------WQV--W-PAI-GVT-------FV-V---VG-----PVL YAIIALPNA---WRP--------------------------------------------------------- ------------------------RFRVRS------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------HAR---------------------------------- ---------------------------------LFFD-----CTWF---TTT--------VLL-----KQT- --------G-KEP-SSSHKARFFIII------LSIS----STYVINDMYSA-----NL-----TS-LLAKPG R--EK-----------------------AIN-----NLNQLEKAMAT-------------------RGYD-- -----------LYVER---------HSSSY---------------SLF----E------------------- ------------------------------------------------NG-TG--------IYSRL------ -WQMMNRRQT----------------------------------------------HFLLESVEE--G---- VQLVR----------D-S------TN-K-A-VIAGRETLFFDIQRFGASN---------------------- -----FHLSE--KLNTAYS--------------------------------------------------AIA LQLG-C-P-------------------------YIEEINKI-----------LMAIFEAGIITK-------- -----------------MTENEYE----------QLGKK----------------KQTTSETEKELIPGVKK -------E-NRRVAKVSEDNEK--LQPISIKMLQGTFYLLC-------------IGNIF-SGF----ILLAE ILV--------------------------------YK-H----------RK--------------------- ------------------------------------------------------------------------ ------------------------------------TYKHKKRRHRFV----YL------------------ ------------------------------------------------------------------------ -------------------------------------RKI------------RHSVASKFGAVVDAVRRVY- ------------------------------------------------------------------------ -----------------------------------------------------RRAMHDAFV---ATLEY-- -----------------------------------------------LE----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >TcasIR41a.1/1-618 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------TKMLFNNF------------------------------- ------------------CINILVNF---IINNYHKNSRC-------------------------------- ------------------------------------LLIFTD-GDFDYKGEI-------------------- ------------------------------------------------------------------PTVRIK -ATNGSFN-----------------------------------SYLIFNY------HGC------------- ------QSVII-----------YTSNVT-------------------------------------------- -----------------------ALLIK--------FETEIR----------LKME--RFNE---------- --------RKFLIV----------------P-----------------------------QNPSEDF----- ------------------------------------------------------------------------ ---------------------------DKFFNLK--------QL---------------------------- ---------YFISDLLLVL----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------PTH-NDTI--------------------- ---------------------FDLKTHKYVG------------------------------------VIDNN EPVLLDRW-------------------------------------------------FSQNQSFLF------ GK---------------------------------------------------------------------- -------------------------------------N-L------YPNK--------LQN----------- ----------QLGRP-LKMATFT------------------------------------------------- ---------------------------------------------------------Y-EP--------YSI IGNV---------------------------------FEQFFE----------------------------- -----------NDFIL------------QGKSVGEH-------------------H------GSE-L----- ------------MSAVQFAL-K----------------------Y----N----M----------------- ------------T----PVPVINEKDY-----------WGD------------------------------- -----------------------------IFPNW---------------S--------G------------- NG------------------------LLG---NL--------------VD-D--------------K---AD VGFS-----------------------------------------------------------ALYTWEFC- -YH------F--L-----------EL-S-KP-----LVRTG---ITC-------------L-VPA------- --------------------------------PKLSER----------------WLTPLFS---YS------ ----------------------------------SYL--W-FCI-ILT-------LV-I---AI-----FVL SLVLFC------------------------------------------------------------------ -------------YN--HNKTLNLNYPL-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------KRKTTYIHFL-------------ES--------------- -------------------------------------------AVT---IVL--------KPV-----FQQS L-------TLREL-PIEIASKLLMGL------VLL-----LALFLTSSYGS-----GL-----AT-VMTIPT Y--EN-----------------------AIN-----TVEDFANS-----------------------GLD-- -----------WGATQD----------------------------AWIMSI-Q------------------- -------------N----------------------------------AE-EQR-------YV-KI----VS KFHPISEEE----------------------------------------------LFQFSKSGKF--G--FS IERLP-------F----E-------D-Y-A---------------------------IGDYIKEDVID---- N----FHLMKEDLYWE----------------------------------------------------QCVI MLRK-NSV-------------------------LLPALDLF-----------ILKIFEAGLISH-------- ---WQN-----------EAVDLYM--------N----PK---------------VQRAVKFYRQGQEH---- -------T----------------VVKLQWSHVKGPFALLL-------------IGLCI-SFI----IFILE LTLK----------------------------------K--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------KRNQF-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >TcasIR64a.1/1-598 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------NKISLILVI----LSKTETY-------------------------------------------- ------------------------------------------------------------------------ --------------------------IIKSCLSNAIVDFAILA----------------------------- -----NVAFSLRI-----------SC-----YKLFMHIK--LIANVF------YNQL--------------- -----------------------------------------D-QVLNR------------------------ --------------------NHYHLAV------------------------------------------IID S--------------------------------------------------------GC------------- ------ID-YA------------DF-AI--------------------QD---------------------- ----------------------KKYF----------YE---------------T------------------ --------YHWLVPT----TPQNL--------------------------------------NNSLN----- ------------------------------------------------------------------------ -----------------------------FLQKS-------------------------------------- ----PLN--IN-SDVN-------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------VAIL------------------ -----------------------------------------------NGEG--------------------- --------TK-----------WS--ILDVYNPASSHH----GQF---------------------------- TVTKLGLC--------------------------------------------------DETNG--------- ------------------------------------------YQAKIA------------------------ --------------------------------GN------------------KY--WSRKN----------- ----------MTGVQ-FKSAVV-------------------------------------------------- -----------------V---------------------------------------P-DP----SI-KLN- ---------------------------------------DYLT----------------------------- -----------SD--K--------------------------------------NRQLHSMHRFQ-S----- ------------VTVNYCRE-M----------------------Y----N----------F----------- ------------S----LEIQR------------TNS-WGYLT----------------------------- -------------------------------PNG---------------H---F------------------ DG------------------------LVG---LL--------------ER-R--------------L---VD FGSS-----------------------------------------------------------PLIYK---- -LDR---MPV--I-----------DY-SYGN-----WVLR----STF-------------I-YRR------- --------------------------------PKIIEASYK---------------IFLRP---LS------ ----------------------------------RTV--W-ICI-VLM-------MV-L---LM-----LFL KVVFSRE----------------------------------------------------------------- ---------------------KRLLQKR-------------------------------------------- -----NLV---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------DSS---------------------------------- ----------------------------------WSF-----LFLF---TLG--------AFC-----QQG- ---------ATCH-PQLLSSRTLSIF------VFL-----FCILTYQFYSA-----SI-----VSYLLIDPP ---R------------------------KIN-----NLKDLSDSNLR------------------------- -----------AGIE----------DILIDR--------------NYF----V------------------- -------------Q----------------------------------TT-DP--------VAIEL------ -FNK-KIK----FSNNN----------------------------------------SGFYEPWD--G---- LDLVK----------Q-G-------G-F-A-FHVETSTAYPIIEETFTN--------------EEICELEE- -----VQMYR---TQP----------------------------------------------------MHTN LQKN-S-P-------------------------FREMMNY-----------CMLHLVENGLMYR-------L RKYWDA-------------------------------RKP-----------------MCIESA--------- --------------------KKFTF-NVGLKEFSSGLIVLS-------------YGILI-SLG----LLLRE VIV--------------------------------H-------------KK--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >TcasIR68a/1-690 ------------------------------------------------------------------------ ---------------------------------------------------------------------MIK N----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------L------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------LPY---------------------------------- ------------------------------------------------------------------------ -------------------------KC-VV--------LISD-DIYG------------------------- --------------------GTFTKSWYR--RFGP-----------------------------FITFVVI- -----------------------RVDEYEDLLSPFE----ETQACLDTAK-----NEGC------------- ------QMYLI------LLSN--ALQVS-------------------------------------------- -----------------------RLL-----------RFG------------DKY---RVIN---------- -----TR-AKFVLL------------------------------------------YDNRLFDKPLF----- ----------------------------------------------------------------------Y- ------------------------------L------------W---------------------------- ---------KRIINVIFIR----------------------------------------------------- --------------------------------RYSGQ----------------------------------- ------------------------------------------------------------------------ ---------------------------------------------KSDTKKN-------------------- ------------------MPWYEITTVPF-----------------------------------PTQITSIL IPRRLDIW---------------------------------------------------------------- ------------------------------------------------------------------------ --------T-----------------KSKFRKGI---D-L------FRDK--------TSD----------- ----------LRNQT-LKVAAFS------------------------------------------------- ---------------------------------------------------------H-IP----------- ---------------------------------------GTTK-----SL---------------------- ----------QEKTARTV---------------------------------------IGNFSGTE-V----- ------------EILQTVSA-A----------------------M----N----------F----------- ------------H----CELYE-PVNV---DV---DL-WGG------------------------------- -----------------------------KQSSG---------------K---Y------------------ TG------------------------LVG---EM--------------VS-T--------------N---AD IALG-----------------------------------------------------------DLYYT---- -PYI---LDL--M-----------DL-S-IP-----YNTEC---LTF-------------L----------- -------------------------------TPES-LT-DNSWK------------TLILPFKYFR------ ----------------------------------PAM--W-AAV-LVC-------LL-I---CG-----AVF HALARF------------------------------------------------------------------ -------------------------HETI------------------------------------------- SQNKSQVLE-----IHTKRKKIIILSICPEIEKLDSNLKY-------------------TKMRE-------- ------------------------------------------------------------------------ --------------QYKP-----------PRFEGQSIG-LYQFS------------EPF------------- ------------------------------------N-----SVLY---TYS--------MLL-----LVS- --------L-PKL-PTGWSLRMLTGW------YWL-----YCLLLVVAYRA-----SM-----TA-ILARPT P--RV-----------------------TID-----TLQELVNSRLK-CG---------------------- -------------------------GWGEI-------------NRQFF----K------------------- -------------S----------------------------------SL-DP--------ITKLI------ ----------------GENF-------------------------------------ELVNDSNE--A---- VDRVA----------Q-G-------V-F-A-FYENSYYLKEALVKRQLRF--QIARTTQNQSEREMRDI--A REDRNLHIMTDC-VIK-MP-------------------------------------------------ISIG LQKN-S-P-------------------------IKPRVDKY-----------IRRVLEAGLIKK-------- ---W---------------LQDVM-------------ASILNA----------------------------- ---------------EVQSTQEEMKAIMNMKKFFGAIVALF-------------IGYFI-SVV----VLIVE NV---------------------------------YF----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----HFFVKRNPHYNKYTRSIHH-----------VKKAE-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >TcasIR75q.1/1-574 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------SFL--GTILTV------YKQLAEKKI---------- --------------------------------------VL-N-VLTNH---WKINQT--------------- -------KLS-------------QHTFL-----------------------------------------VGD TL--------------------------------------------------------CPQF---------- ------NS-LL------------SH-VS--------------------KFF--------------------- ----------CYQNSQ---QTLGQII----------TS---------------S------------------ --------XKWLVFDQN------------------------------------------------------- ------------------------------------------------------------------------ --------S--------------------TVNTN-------------------------------------- ----DLL--LD-SNFAVAS----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------QISN--------------------- --------GR-----------FH--LKLCYKRAPNET----IKF---------------------------- --NEIGVF--------------------------------------------------SNGFEY-------- ------------------------------------------------------------------------ -----------------------------YNHFI------------------PT--RNRSD----------- ----------LSGVN-ITVSYV-------------------------------------------------- -----------------V---------------------------------------T-KP-------DYP- ---------------------------------------FDV------------------------------ ------------EDYR--------------------------------------FRHLEAFSKLS-Y----- ------------AMVYPMLE-M----------------------L----N----------C----------- ------------T----KKFIQ------------RSS-WGYKG----------------------------- -----------------------------ANETQ---------------F---V------------------ GG------------------------MFG---DI--------------QN-G--------------T---AE IGGT-----------------------------------------------------------VSFYT---- -VDR---MSV--V-----------DY-LSVT-----TPSD----LKF-------------I-LRA------- --------------------------------PPLSYV-NN---------------LFTLP---FD------ ----------------------------------TKV--W-YCL-YFI-------VG-V---TV-----LIL YVIVRCESTYE-----------------------------------------------------N------- -----------------------ALERR-------------------------------------------- ---------------NNIDN---------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------IKPK---------------------------------- ----------------------------------FFD-----VVML---QIE--------AIT-----QQG- ---------SENE-PKTMSGRIAVFI------VFL-----VLMFLYTSYSA-----NI-----VV-LLQSTS ---A------------------------NIN-----TLQDLLNSKIT------------------------- -----------LGVE----------DVVYSH--------------HYF----E------------------- -------------T----------------------------------QT-EF--------TRKSI------ -YEK-KVA----PKNQK----------------------------------------SNFMTTEM--G---- IEKMK----------D-E-------F-F-A-FHVETTAGYKQIMDTFQE--------------HEKCGLIE- -----IDYLN---VLY----------------------------------------------------PSIT IRKN-S-P-------------------------YKEIVKV-----------NFRKIYESGIRHR-------Q LNRIYY-------------------------------KKP-----------------HCVG----------- --------------------KGGSFKSVGIVDIYFSVEIFA-------------IGCFM-ALW----LLLLE VL---------------------------------F-----------K-KKI-------------------- ------------------------------------------------------------------------ ----------------------------------------K------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------FLVQ--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_002402308.1/1-659 glutamate receptor, putative, partial [Ixodes scapularis] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------MNNKNM----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------MT---------- -----FH-REFVSV----------------------------------------------VTQ--PI----- ------------------------------------------------------------------------ ----DDDFQKL---------------VV-GF----------------------------------------- ---------PDGANVLAAY-----PEIADN--DCPVEPG-----------CQLPL-AMETV-A--------- ----KTIG---DKLEKGTYRTTE------------------------------------------------- ----------FFTTKFIFSNT---------------------------SKSLL------------------- -----------------------------------------------LASGKCG------------------ -----------------QCARFIIRS-------------------------------------VAKVQG-IQ EFLKIGEW-----------------------------------------------------TPAVG------ --------------------------------------------LKMTHK-------Q-------------- ---------------------------------------F------FPGI--------MGN----------- ----------LGGIR-LTIGVIN------------------------------------------------- ---------------------------------------------------------D-PP--------MSV -----------------------------------------VE----------------------------- -----------MSP-D------------RKTV--------------------------KNVTGTM-A----- ------------DMVEALAK-G----------------------L----N----------F----------- ------------T----YTWKV-PKE---------EI-PGS------------------------------- -----------------------------KEN-G---------------N---W------------------ NG------------------------LIG---ML--------------AT-G--------------E---AD LGAY-----------------------------------------------------------GFSVT---- -KER---SEV--V-----------NF-T-SA-----YDESP---YKI-------------L-VPK------- --------------------------------PRA--N--YKY-------------LFLDP---FT------ ----------------------------------WDT--W-VAV-LVS-------LV-L---IG-----PIL WGIHCA------------------------------------------------------------------ --------------------SPFY-D---------------------------------------------- ---------------------------------------Y-----------------HGLR----------- ------------------------------------------------------------------------ ----------------------------------DNKG-LF------------------------------- ---------------------------------LLQN-----CEWY---CFG--------AII-----QQG- --------G-IHL-PEAISGRILVGF------WWL-----FVIVTLTTYSG-----NL-----VA-DLTFPK I--RN-----------------------PVD-----SVENLVAHR---------------------GYMR-- -----------WGAFK---------GQAVF---------------ELL----K------------------- -------------S----------------------------------QE-QG--------PLKVL------ -SDRMNVF---EPN-----------------------------------------------HEMW--V---- LDQVR----------L-G-------Y-M-A-LIGSEVNMFHYLGRELNR--------------TGECD---- -----FAVARGE-VIR-DV-------------------------------------------------KSLA VAPN-F-A-------------------------FLERLNNEPDHDGRPPPRRLKRLVESGLVMR-------- ---W---------------KKKYW-------------PQ-------------D---NECTVESKPQA----- ----------------------GDIRKITLRHMTGSFWVLG-------------VGFFS-SFA----ALFVE FV---------------------------------------------------------------------- ---------------------R-------------------------------------------------- -------------------------------------RKRELTAPPTHK----------------------- --PPTVIHT--------KSPFFTRTEYSGKDTL------TTDRFATDYGGRGP------------------- -----------------------------------------------------RDNAG-FA----------- ------FSPPNSPFR----------------------------YN--------------------------- -------------GYP-----------------------------------------N-------------- --------------------------------------------------NRSDLIP--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------YNYPARR-------------------------- >XP_003743737.1/1-917 ionotropic receptor 93a [Galendromus occidentalis] ------------------------------------------------------------------------ ---------------------------------------------------------MWLRVLLVASIG--- ------------------------------------------------------------------------ -GWVA-----------------------------------------------------------------QA HQ-------------------IKVQIVPD------------------------------------------- -SQTEVDG---QDV----REYIMSRH-------AEYNETLAPGGNYLTFLATDIEDVHEL-PERVNPE---- ------KPTRINLNLLV--TAVGCEDTYAAMALQESK-YPSAMLLALNR----------------------- --------------------------------------------------------------------PYCP RF-------------------DADDKETSIRKPFAVSI-----------------PITNGPT---------- ---------------------DVLP--------VLADFRA-MLPLSR------WSEIT-------------- --------------------------------------IITP-QAY-------------------------- -----------------------TNEYLE--MV----MRAVEGVRNND-------RVNS-----AASISLWQ YCSPTMRQNGQCG------------SNSASM-----------RNILDSYR-ASPKKKDD------------- ------REFII-------IGD--EELVL-------------------------------------------- -----------------------EFL-----------ERG------------VDY---QIFS---------- -----LF-REFFII----------------------------------------------LTT--PF----- ------------------------------------------------------------------------ ----SNRVRDF---------------LFDKI----------------------------------------- ---------TSDANIAIAS-----TEVKDE--ECPVKGT-----------CHIDL-PMMAY-M--------- ----ETA----RKNPSLFNPSTD------------------------------------------------- ----------LFTRKYNINKG---------------------------VRDYL------------------- -----------------------------------------------RRSKSCG------------------ -----------------FCAKYTIRT-------------------------------------LTVKAG-RK TFDPVATW-----------------------------------------------------DYFDG------ --------------------------------------------LAMVGG-ANRNTYQ-------------- ---------------------------------------L------FPRF--------LGD----------- ----------MGGIT-LRVGIIN------------------------------------------------- ---------------------------------------------------------E-PP--------MT- ------------------------------------------Q----------------------------- -----------VLS-D------------KGMV--------------------------ISANGTL-I----- ------------DLLKELSR-Q----------------------L----N----------F----------- ------------T----YKFIM-PSE---------PV-PGL------------------------------- -----------------------------KQPDG---------------S---W------------------ SG------------------------LIG---LL--------------VK-Q--------------D---ID VALY-----------------------------------------------------------DFTPT---- -PDR---QEA--V-----------NF-T-VA-----FDESP---YKF-------------L-VPK------- --------------------------------PKP--N--YKY-------------LFLDP---FT------ ----------------------------------WDT--W-LAV-LGT-------VL-I---IG-----PVL WCIHIN------------------------------------------------------------------ --------------------SKYY-D---------------------------------------------- ---------------------------------------Y-----------------YDLR----------- ------------------------------------------------------------------------ ----------------------------------DGKG-LF------------------------------- ---------------------------------KLSN-----CEWY---CFG--------AII-----QQG- --------G-IHL-PDAISGRILVGF------WWL-----FVIVTLTTYSG-----NL-----VA-DLTFPK I--RN-----------------------PFD-----TVDSLL--K---------------------SGMQ-- -----------WGAFR---------GQAII---------------EIL----R------------------- -------------L----------------------------------QQ-QG--------PLTQL------ -SEKLMQI---ETA-----------------------------------------------HEGW--I---- LKNVA----------E-G-------T-M-A-LIGSEVTLFHFIGKQYLA--------------TGKCQ---- -----YAVAKEE-IIR-EV-------------------------------------------------KNLA VRPG-F-P-------------------------FLTRFNAISD-----PHCRLLRMVETGLVIR-------- ---W---------------KKKFW-------------PK-------------E---NECIVQSKPQA----- ----------------------GDIRKIEIPHMEGSFWVLG-------------VGFLV-AFF----LLGIE LL---------------------------------------------------------------------- ---------------------R-------------------------------------------------- -------------------------------------KRRELRDPNSGKT---------------------Q RVSPSEFN---------KENLFRKTNFSDN-----------TNYSTDYGQSGT------------------- ------------------------------------------------------KNSG-YA----------- ------FESSNQPFR----------------------------YT--------------------------- -------------GFP-------------------------------------------------------- --------------------------------------------------NRTDLIP--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------YNYPARRY------------------------- >XP_013788799.1/1-643 ionotropic receptor 25a-like, partial [Limulus polyphemus] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------A------------VSK---GMTG---------- ----RGH--AWFFV----------------------------------------------TKD--------- ---------------------------------DARQLTCN---------CTSVNFMIFSPQ---------- --------------------EIE-----PKIVGN--------SV---------------------------- ---------PTQTDMAFYF----D--------------------------LALI--TVTAL-S--------- ----RQLDLGS-------------------------------------------WPTTLDYPECGM------ -TMN-EKQNDQRKK-IDLLSA---------------------------INQVS------------------- ----REGVYDRPLII-------------------------------TDKKGYQD------------------ -------------------IILNIVNVEIRN-------------------------------------KKRV KEETVGVW--------------------------------------------------SLGYP--EH----- --------------------------------------------IVSN---------EG------------- ----------------------------FSKKTF------------------------DDF----------- ----------KAVII-YKITTVA------------------------------------------------- ---------------------------------------------------------E-Y------------ ------------------------------------------------------------------------ -----------NKK-L-------------GS---------------------------EEFQGYC-I----- ------------DLINDIKK-I----------------------L----Q----------F----------- ------------E----FEISE-CPD---------KM-FGI------------------------------- -----------------------------MNATS---------------G---W------------------ NG------------------------MIQ---EL--------------IE-K--------------R---AD IALA-----------------------------------------------------------PLSVM---- -AER---ETV--V-----------DF-T-VPF----YDLVG---ISI-------------L-MKK------- --------------------------------PQV-PS--SIFK-------------FLTV---LE------ ----------------------------------TNV--W-ASI-IGA-------YF-F---TS-----FLM YAYECF------------------------------------------------------------------ --------------------SPYS-NRN-------------------------------------------- -----N------------------------------N----------------------------------- ------------------------------------------------------------------------ ----------------------------------QNSR-EF------------------------------- ---------------------------------NLKE-----CLWF---CIT--------SLT-----PQG- --------GGEA--PRNLSGRLVAAT------WWL-----FGFIIIASYTA-----NL-----AA-FLTVSR L--DS-----------------------PIT-----SLDDLANQY----------------------KIK-- -----------YAPQK---------GSSSQ---------------TYF----E------------------- -------------RMAYIEERFYEIWKDMSLNDSLSITERAKLAVWDYPI-SD--------KYTKI------ -WLTIKEA---NM----------------------------------------------PLTFEE--G---- VQRVKESKGS-----H-E-------G-F-A-FIADSTQVKY--------------------AAYSDCD---- -----LQVVGNE-FSR-KP-------------------------------------------------MAIA VQEG-S-Y-------------------------LRDQLSSA-----------ILELLNQRKLEE-------- ---L---------------KEKWW-------------NT-------------NSKLLACEDSEER------- ------------------------NDGIGIENIGGVFIVIG-------------VGVGT-ACL----TLLAE HL---------------------------------YY-K--------R-FQP-A------------------ ------------------------------------------------------------------------ -----------------------------------PKIVP-IKKYQIT------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------SPKK--------------------------------------------------------- ----------------------------------------------DKY----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_013794655.1/1-517 glutamate receptor ionotropic, delta-2-like [Limulus polyphemus] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MPA ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------D------------- ------RIPK------------------------------QVLYGELSEGKRSVG----------------- --------------------------------------------------------------GQKKRFKDCL K------------------------------------------------------PSLQ------------- -------------------EFDINH--------VNWESL--AQDRFL------WRTKVR------------- -------------------Q---------G--------LVTA-ECK-------------------------- -----CRLVAEGKRAARKDRVLLNGDPMR--FVDKIQLLNT-DLTIV----------------VECIIAMLG NHSDGLWRD----------------K---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------L----------------------------------------- ---------APVDRYTYGS----NGGVSNGIKDTNKDMDFQLR----------------------------- ------------------------------------------------------------------------ -------LPRM------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------N----------- ----------LQNKT-LKIASVT------------------------------------------------- ---------------------------------------------------------R-IP--------FQN -----------------------------------------IT-----R----------------------- ------------LS-N-------------GEY---------------------------VEGGFT-F----- ------------EIINQLSS-F----------------------F----N----------F----------- ------------S----YKIVM-PED---------NA-FGKL------------------------------ -----------------------------RDENG---------------TK-KW------------------ NG------------------------MIK---QL--------------LD-K--------------E---AD LAAA-----------------------------------------------------------MFTIT---- -EDR---REV--V-----------EF-T-KN-----IYLDG---IDI-------------L-MQY------- --------------------------------PKE-SD--NTS-------------ALLSP---FS------ ----------------------------------INV--W-AMI-IAS-------FF-A---MG-----PVI YAIQVL------------------------------------------------------------------ --------------------QRKL-V---------------------------------------------- --------------------------------------KL-----------------DETT----------- ------------------------------------------------------------------------ ----------------------------------DRKN-RF------------------------------- ---------------------------------TLVE-----CVWF---VYA--------GLV-----KQG- --------S-ELS-PIYDSTRILFAT------WWI-----FTLIVTAFYTA-----NL-----TA-FLTLPH Y--KT------------------------IK-----SLDTLLQ-H---------------------SETT-- -----------WLVKY---------GGALD---------------AAI----E------------------- -------------E----------------------------------GH-GK--------IFQKL------ -RSSFRMG---QGK--------------------------------------------HLRSDYE--A---- RSLIE----------K-G-------G-Y-V-YLHETLSLKYLLLESYQR-------------SNGKCV---- -----LALANQN-FFE-KP-------------------------------------------------FGFA YPKG-S-P-------------------------YAFAFN--------------------------------- ------------------------------------------------------------------------ -------------------------------EL--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_013794655.1/1-517 glutamate receptor ionotropic, delta-2-like [Limulus polyphemus] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MPA ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------D------------- ------RIPK------------------------------QVLYGELSEGKRSVG----------------- --------------------------------------------------------------GQKKRFKDCL K------------------------------------------------------PSLQ------------- -------------------EFDINH--------VNWESL--AQDRFL------WRTKVR------------- -------------------Q---------G--------LVTA-ECK-------------------------- -----CRLVAEGKRAARKDRVLLNGDPMR--FVDKIQLLNT-DLTIV----------------VECIIAMLG NHSDGLWRD----------------K---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------L----------------------------------------- ---------APVDRYTYGS----NGGVSNGIKDTNKDMDFQLR----------------------------- ------------------------------------------------------------------------ -------LPRM------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------N----------- ----------LQNKT-LKIASVT------------------------------------------------- ---------------------------------------------------------R-IP--------FQN -----------------------------------------IT-----R----------------------- ------------LS-N-------------GEY---------------------------VEGGFT-F----- ------------EIINQLSS-F----------------------F----N----------F----------- ------------S----YKIVM-PED---------NA-FGKL------------------------------ -----------------------------RDENG---------------TK-KW------------------ NG------------------------MIK---QL--------------LD-K--------------E---AD LAAA-----------------------------------------------------------MFTIT---- -EDR---REV--V-----------EF-T-KN-----IYLDG---IDI-------------L-MQY------- --------------------------------PKE-SD--NTS-------------ALLSP---FS------ ----------------------------------INV--W-AMI-IAS-------FF-A---MG-----PVI YAIQVL------------------------------------------------------------------ --------------------QRKL-V---------------------------------------------- --------------------------------------KL-----------------DETT----------- ------------------------------------------------------------------------ ----------------------------------DRKN-RF------------------------------- ---------------------------------TLVE-----CVWF---VYA--------GLV-----KQG- --------S-ELS-PIYDSTRILFAT------WWI-----FTLIVTAFYTA-----NL-----TA-FLTLPH Y--KT------------------------IK-----SLDTLLQ-H---------------------SETT-- -----------WLVKY---------GGALD---------------AAI----E------------------- -------------E----------------------------------GH-GK--------IFQKL------ -RSSFRMG---QGK--------------------------------------------HLRSDYE--A---- RSLIE----------K-G-------G-Y-V-YLHETLSLKYLLLESYQR-------------SNGKCV---- -----LALANQN-FFE-KP-------------------------------------------------FGFA YPKG-S-P-------------------------YAFAFN--------------------------------- ------------------------------------------------------------------------ -------------------------------EL--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_015907376.1/1-982 ionotropic receptor 93a-like isoform X1 [Parasteatoda tepidariorum] ------------------------------------------------------------------------ ------------------------------------------------------MKTFFVKIFTFLLVL--- ------------------------------------------------------------------------ -KKIF-----------------------------------------------------------------CI EN-------------------ITIVPIVD------------------------------------------- -PSVAQGG--TDDTRLNIVNLKSELQ-------EIAGDDATI-----------IID------KRLHPSL--D --QLLFTEKIQDISAII--SVVKCASYLYDMNTVSMT-LSDTIALAVLE----------------------- --------------------------------------------------------------------RGCP R----------------------------PTFDVGVGI-----------------PYITKTY---------- ---------------------DIVP--------LLVDLRSDNRLIEK------WDDIV-------------- --------------------------------------ILYD-DTI-------------------------- -----------------------DLNSLE--TIVSMLQSTGTKKR-------------------ATTLTLYG VCRGEL----ICE------------DMTTVI-----------RECLTPYI-ASDSQK--------------- -------YFMV-------LSR--EKTFR-------------------------------------------- -----------------------KII-----------DQA------------KKL---TMME---------- -----AE-RHWLYI----------------------------------------------ATEVPND----- ------------------------------------------------------------------------ ----VEFVDD-----------------ITNL----------------------------------------- ---------PPECNMALVYPV--SPKPEEE--GCLKPKG-----------CQPSL-ILKAY-V--------- ----TAIRELIQKGLYDMTTSEA------------------------------------------------- ----------KSMTKSKIRSY---------------------------TLENL------------------- -----------------------------------------------KKETDCG------------------ -----------------GCFMAMIKTTAY-------------------------------LKPKTETAEALS DYETVGTW-----------------------------------------------------SLLGG------ --------------------------------------------IQMNGP---------------------- ---------------------------------------L------YPLS--------TGN----------- ----------LRGKL-VRIGIFH------------------------------------------------- ---------------------------------------------------------S-PP--------CAV -----------------------------------------IH----------------------------- -----------EDG-P------------KTT-----------------------------YSGLA-V----- ------------DFITALSD-E----------------------M----N----------F----------- ------------T----YNFIA-PPE---------EQ-SGY------------------------------- -----------------------------KKRNG---------------E---W------------------ TG------------------------LIG---QI--------------TR-G--------------E---VE FVAH-----------------------------------------------------------CFFVT---- -PER---LEA--V-----------NF-T-HA-----VDIMA---YTF-------------L-TKR------- --------------------------------PEQ--E--HKY-------------LFLAP---FT------ ----------------------------------NDT--W-LCV-FIT-------VL-I---VG-----PVL WLVHRA------------------------------------------------------------------ --------------------SYYY-R---------------------------------------------- ---------------------------------------F-----------------YNLV----------- ------------------------------------------------------------------------ ----------------------------------EKGG-LF------------------------------- ---------------------------------DFSN-----CAWY---VFG--------AIV-----QQG- --------G-IHL-PLAYSGRILVGF------WWL-----FVIVTVATYSG-----NL-----VA-VLTFPK I--RS-----------------------PIN-----TFEDLLANQ---------------------RSIK-- -----------WGVLE---------GEGLI---------------EKL----R------------------- -------------T----------------------------------ST-SE--------TYRNV------ -GKRLVIL---KQD-----------------------------------------------DKPK--W---- MKKIK----------D-N-------D-L-V-LIASRFELLEIMGKSYNE--------------TNKCY---- -----YAVGAVD-VHA-ES-------------------------------------------------VSLA VRKN-W-P-------------------------YLEHVNSE-----------VERLFECGIFLK-------- ---W---------------KRDAS-------------PP-------------D---NECTLALKPQA----- ----------------------GDTREINVSQMVGSFYILM-------------FGLCG-SIL----FLMSE LV---------------------------------YI-L--------------------------------- --------------------CRNK----------------------GHF----------------------- ---------------------------PAN-MRVMHSKRSKFIIPFLNA----------------------- --GSQKINK--------KDNFMQSRMYPGIRDLDKVKNRKQKKNATSF-SNGT------------------- ------------------------------------------------------DNRG-FSKD--EWNN--- -----RRSTMNSDVRLDEYGRRD-------------------IYN--------------------------- -------------NYDSDNAE------------------------RTNF---GGEYTN-------------- --------------------------------------------------NNSFAIRRSYENAERNT----- ------------------------------------------------------------------------ ----------------------------------------QANEQSRYGNN--------------------- ----------------------------------D--SYFTYENGDHQRQ---------------------- >XP_015908388.1/1-358 glutamate receptor ionotropic, delta-2 [Parasteatoda tepidariorum] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MAAA-----------------------------------------------------------PISIT---- -QER---QEV--V-----------TF-G-TV-----LFEDS---LGL-------------L-FSK------- --------------------------------PQD-RQ--NSG-------------ALIAP---FS------ ----------------------------------TTV--W-ITV-ILI-------AL-M---VC-----PIL SLLVRL------------------------------------------------------------------ --------------------STWV-KRQ-------------------------------------------- --------------------------------------RK-----------------RRIK----------- ------------------------------------------------------------------------ ----------------------------------DSNL-YM------------------------------- ---------------------------------NFGD-----CIWF---VYS--------GLM-----KQG- --------C-EKS-SSSIPVRLLMAA------WWL-----TSLLIAAFYTA-----NL-----TA-FLTTET ---SI-----------------------SAL-----TIKDLTE-----------------------LGFR-- -----------WTFKK---------GTAFS---------------NKL----L------------------- -------------KE------------------------------ENFKA-KD--------EFFLL------ -RESLRKK---LGK--------------------------------------------SVNSEED--A---- MEYT-----------Q-K-------G-Y-S-YIQEVNILNYLLFQDFKA--------------RQYCK---- -----FHVLDLN-LFK-HS-------------------------------------------------AAFA FPRG-S-P-------------------------YAIHFSHY-----------MEALRKNGLIQK-------- ---W---------------MQQHL-------------SK-------------T---DVCTLHHDNKLS---- ----------------------QKEQALTLNDVYTAFYLLL-------------IGIFA-SSI----CFITE RY---------------------------------YS-KH-------R-D---K------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------NRKIG-------------- ------------------------------------------------------LIRNKRK----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_015908388.1/1-358 glutamate receptor ionotropic, delta-2 [Parasteatoda tepidariorum] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MAAA-----------------------------------------------------------PISIT---- -QER---QEV--V-----------TF-G-TV-----LFEDS---LGL-------------L-FSK------- --------------------------------PQD-RQ--NSG-------------ALIAP---FS------ ----------------------------------TTV--W-ITV-ILI-------AL-M---VC-----PIL SLLVRL------------------------------------------------------------------ --------------------STWV-KRQ-------------------------------------------- --------------------------------------RK-----------------RRIK----------- ------------------------------------------------------------------------ ----------------------------------DSNL-YM------------------------------- ---------------------------------NFGD-----CIWF---VYS--------GLM-----KQG- --------C-EKS-SSSIPVRLLMAA------WWL-----TSLLIAAFYTA-----NL-----TA-FLTTET ---SI-----------------------SAL-----TIKDLTE-----------------------LGFR-- -----------WTFKK---------GTAFS---------------NKL----L------------------- -------------KE------------------------------ENFKA-KD--------EFFLL------ -RESLRKK---LGK--------------------------------------------SVNSEED--A---- MEYT-----------Q-K-------G-Y-S-YIQEVNILNYLLFQDFKA--------------RQYCK---- -----FHVLDLN-LFK-HS-------------------------------------------------AAFA FPRG-S-P-------------------------YAIHFSHY-----------MEALRKNGLIQK-------- ---W---------------MQQHL-------------SK-------------T---DVCTLHHDNKLS---- ----------------------QKEQALTLNDVYTAFYLLL-------------IGIFA-SSI----CFITE RY---------------------------------YS-KH-------R-D---K------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------NRKIG-------------- ------------------------------------------------------LIRNKRK----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_015914913.1/1-591 glutamate receptor ionotropic, delta-1-like [Parasteatoda tepidariorum] ------------------------------------------------------------------------ ---------------------------------------------------------MFQKPLLYHFIA--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------ELVTN-------LMH-----------------WQWIV-------------- --------------------------------------IIEK-RFIEV------------------------ -------------------------------------------------------------------DPLLA EAL--------------------------------------------------------------------- ---FRRNISLV------CFTSKFEHKLQ-------------------------------------------- -----------------------ELL-----------RHHDKVP-V-VMLPSNES---SLKLV--------- ---EKSHRIQWVIL---VP----------------------------------------RQYSENIS----- ----------------------------------------------------------------------F- -------------------------NEFSQF-----------YI---------------------------- ---------NNHIMFVFPAPK--NTY------------------------------ILKSL----------- --------------------------------------------------------------EVP------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ SLTLI------------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------TTNSWNNE---T-G------FSNN-SSFLERAIQP----------- ------------ARP-LRVAMEK------------------------------------------------- ---------------------------------------------------------H-FP--------FFR LP---------------------------------------------------------------------- ---------------SA----------------------------------------LQKPTGSD-I----- ------------ELLDSLAA-S----------------------L----K----------F----------- ------------T----YQIFR-SID---------GS-WGSPN----------------------------- --------------------------------GS---------------N---W------------------ NG------------------------MIG---ML--------------MR-N--------------E---VD VALS-----------------------------------------------------------GMTVT---- -YGR---ATA--V-----------RF-S-MP-----YAFDR---ITF-------------V-TKK------- --------------------------------PSR-KL--KTW-------------VIFWP---YK------ ----------------------------------VQV--W-LCI-ALS-------IL-A---VS-----IIM TLLQNAM----------------------------------------------------------------- -------------------KPN-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------SRTQ------------------------I--------- ---------------------------------PFKD-----VSLY---IFQ--------SLL-----NQG- --------YYN---ARETHCRVLMSF------WWS-----FCITVVAGYNG-----SL-----MS-FMAHPG Y--NQ-----------------------ALQ-----TVPQLVDAIKY-------------------KQFA-- -----------VGTIR---------KSADY---------------TIF----R------------------- -------------D----------------------------------SE-EE--------DLQVM------ -LESME----------SNPN-------------------------------------NMVPHDVD--G---- LRESL---------IR---------D-Y-A-YIGGELTVKADIWDT-------------------------- ---RLFLFGLDS-FLQ-YG-------------------------------------------------YAIA FAPD-F--------------------------DNIEIFNRK-----------ILQLRESGVVDK-------- ---W---------------IEDII-------------EKSQLRG--------LFDGSESEIIDSEEL----- ------------------------THILRVDDVQGAFALLC-------------IGYAV-AGA----SCVIE VQ---------------------------------VK-RY-------K-QQQKRSRK--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------RKQVIMYK------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_015921456.1/1-500 ionotropic receptor 25a-like [Parasteatoda tepidariorum] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------MSLSE-MLVLIVLHLR--------------WKNV--------------- --------------------------------------FILN-SDYDITA---------------------- -------------------------------SVVKSLNSN------------------------GILVISFE VEEMDTY----------------QWPVRFGVNPPL------------------------------------- ------DGFIA------IVGS--PNTAN-------------------------------------------- ---------------------YTSQI----------VQSL-----------K-KKS--MVNSS--------- --------QLWIFG---------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------LNGLVNLGNLLD---DF---------------------------- ---------EEGDQVLIVG----------------------------------------------------- ----NNI----------------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------FNSSEFLHPDL--------------- ----------------NVLSVLQLWSLHS-------------------------------------IGNGNI TF-QLKIL---------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------NESFENCTLEEEP-----L------FNKP--------FTN----------- ----------FGGRI-LKVSALG------------------------------------------------- ---------------------------------------------------------S-PP----------- -----------------------------------------IK----------------------------- ---------------E------------------------------------PPLPGKRKWRGYI-F----- ------------RVINILGD-M----------------------F----N----------F----------- ------------T----YVVKE-ADN---------RD-YGM------------------------------- -----------------------------QQEDG---------------T---W------------------ TG------------------------MIR---EL--------------IR-K--------------T---VD IGTG-----------------------------------------------------------DISWT---- -LQR---NLA--V-----------DL-T-HP-----IFPET---VSF-------------I-YRA------- --------------------------------PAFYSR---------AW-------ILFQD---ID------ ----------------------------------FRV--W-ISLSTVM-------IA-----GS-----CAY CFILYFE----------------------------------------------------------------- --------------------ATYKNKQNRY------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------LDKNE-IFV------------------------------ ---------------------------------NAAI----RSISS---LYR--------SLL-----GQA- ---I------TRM-PQTTAARTILGT------WLM-----GALILSALYGG-----SL-----TS-RLSLHK S--PS-----------------------PAD-----NLLSLVKRYPN------------------------- ---------ALLALRN---------NSQVH---------------SYF----K------------------- ------------------------------------------------GS-DYW---------RKL------ WLKNMKDNV-----------------------------------------------IPGKYHIED--T---- MKRVH----------E-HD---ERTPIY-A-WIADRYKLR-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_018006919.1/1-465 PREDICTED: probable glutamate receptor [Hyalella azteca] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ M--------------------------NVAG-----------LL---------------------------- --------------------------FV-------------------------------------------- ------------------------FS-----------LLAGAF----GNGTDPSV---P------------- --------PYW------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---DL------------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------LLKSP-----------------HT-----FRF----------- ----------PEAVE-LTVAAEE------------------------------------------------- ----------W------------------------------------------------VP--------HIA -----------------------------------------VR-----E----------------------- -------------D-P-------------V--------------------------NGIVISGPM-A----- ------------NLLDALAR-A----------------------M----N----------F----------- ------------K----YKIVR-PAD---------GA-WGIPR----------------------------- -----------------------------PDGSG---------------D---W------------------ NG------------------------MIG---MV--------------KR-K--------------E---AD LALG-----------------------------------------------------------PFGLT---- -FSR---SRV--V-----------SF-T-SP-----ILIDY---YRI-------------L-VRR------- --------------------------------LKP-QP--DPW-------------GWRNP---FT------ ----------------------------------LGV--W-ISF-VVS-------ML-A---LA-----LAL CGN--------------------------------------------------------------------- ---------------------TRL-FGI-------------------------------------------- -----SHV-------------------------------N-----------------HNET----------- ------------------------------------------------------------------------ ------------------------------------PC-----------------KSL-------------- ---------------------------------SFSE-----HCWL---LFG--------TSL-----SQR- --------T-NWM-PFSLGGRFVLAI------WLL-----IALIATRSYSS-----SL-----TS-LLAVRT I--AT-----------------------PYN-----YLKDLVND----------------------HHVK-- -----------LVFEA---------ATALV---------------EHM----S------------------- -------------T----------------------------------VK-TG--------IYADL------ -AK--QSD---RSRFVTPPQ-------------------------------------LYEAAYS-------- --DVR----------T-S-------D-T-A-LLVEDTTCRKVLSDDFTK--------------TGRCD---- -----FYIGKER-YWP-LI-------------------------------------------------FCMI VRKD-H-P-------------------------IIGAINAR-----------LERFTSQDLYMR-------- ---W---------------LGEQL-------------PN-------------V---TACSAAASKVTVQEP- ---------------------------YSLRGLWGVFVLLT-------------VGLAL-SST----CLALE VI---------------------------------IA-KR-------W-PP--------------------- ------------------------------------------------------------------------ ----------------------------------------V------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_018009548.1/1-632 PREDICTED: probable glutamate receptor [Hyalella azteca] ----------------------------------------------------MAMRAEHVFG---------- -------------------------------------------------GKR-WLTLALVLSLTTSSLGG-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------VLDTRLGVDF---------------------------------- ----------------------LVK--------YVEFTDV-------------------------------- ------------------------LNLNFF------------------------------------------ ---------------------AAPGGALL--A----------------------------------PNAVKQ LSAKRRVAVSTF------------EVADHVAL---------TSAVTRGA----------------------- --------------------Q--AGVLN--AAYLDTPSDL-------------------------------- -----------------------ELL----------REASNQ-------GPLLRR----------------- --------YRWLIL----------------------------------------------CRSVAAI----- ------------------------------------------------------------------------ ----------------------------NTTSSI--------YL---------------------------- ---------PVDNKVMFVE----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------QTSPNS------------------ -------------------TVLKLYDIYQ---------A---------------------------TMFTSQ QVRAVGQF--------------------------------------------------TATGGLS------- ------------------------------------------------------------------------ --------------------------------MA---M-K------DPAQ-S------RTN----------- ----------FTGLH-LRCVTLP------------------------------------------------- ---------------------------------------------------------Q-EP--------FTY -----------------------------------------LA----------------------------- ---------------PG----------------------------------PD--GTTVLQSGHI-A----- ------------DVWRILQN-T----------------------L----G----------F----------- ------------T----YTCRQ-PAD---------MT-FGV------------------------------- -----------------------------LS-NG---------------E---W------------------ GG------------------------MMR---AL--------------VD-G--------------E---AD VIVA-----------------------------------------------------------PLDYT---- -VER---AAA--V-----------DF-T-IG-----LRNTA---TRM-------------V-TKK------- --------------------------------RAL-M--DSTWT------------TFTQE---FT------ ----------------------------------KEA--W-GGT-LAL-------VF-L---AP-----PFL AFITQL------------------------------------------------------------------ --------------------S--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------PSEK-VKI------------------------------ ---------------------------------SLRD-----AYVI---SVG--------ALA-----FQG- --------A-SVE-TTSGAGRIVFIV------IFL-----GTLLTYCYYTS-----AL-----TA-SLTIAS T--TL-----------------------PVE-----SLQDVVNSGH--YD---------------------- -----------IGIKL---------GTSRQ---------------GEF----Q------------------- -------------H----------------------------------SL-TS--------PFREA------ -WQRFIQP---NL------G-------------------------------------LMPTSHQE--G---- IDKVA----------E-G-------G-Y-V-FLLDENVFVYEFGSD--------------------CR---- -----VTLIPPR-YFE-TP-------------------------------------------------TGLA FSQG-S-P-------------------------YVKIFNQL-----------ILRMRNGGILDR-------- ---S---------------WEQLQ-------------PAKNL----------------CDNSDVI------- --------------------------SLNPTQLFTAFLLLM-------------VGAGL-AIL----MLPVE KW-------------------------------------Y-------W-NRYGKK----------------- ------------------------------------------------------------------------ -----------------------------------KVEEEIQ------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------PPSLYWG------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------TWG----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_018010664.1/1-439 PREDICTED: glutamate receptor ionotropic, delta-2-like [Hyalella azteca] ------------------------------------------------------MRRG-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------D-H-MRSQK---------------------- ------------------GPT--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------SPNP--------------------------------------- -PFLMRPW---------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------T------IPHS-PTGESFEAPS----------- ----------DTPGC-ISVAV--------------------------------------------------- -----------------------------------------------------------FP--------RPQ ----------------------------K------------------------------------------- ------------------------------------------------------------------------ -------------------S-S----------------------L--------------CR----------- ------------S----YYFVT-VPDLS----------VGL------------------------------- -----------------------------EVNGS---------------Y---------------------- NG------------------------ATG---MV--------------QR-R--------------E---VD MMLG-----------------------------------------------------------PVSVY---- -LIR---SEV--L-----------DY---APNLW-----------KINS-NY--------L-YRRIT----- -----------------------------SIQPDV---------------L-----IFTKP---FM------ ----------------------------------FEV--W-VCV-LLS-------VL-I---VG-----VVA GLLGLA------------------------------------------------------------------ -------------------VSSFL------------------------------------------------ --------------------------------------------A------------RDGH----------- ------------------------------------------------------------------------ --------------------------------PTGRQG---------------------------------- -----------------------SV-----------------SNTE---IGSLGFVWALQIFL-----SQD- --------S-KHS-PGWKAGRTLGAF------WLL-----VSFMIGAMYKC-----NL-----SA-ILINDK I--KL-----------------------PFR-----TDEEFVSQTDYK--------------------LT-- -----------WIDGQ----IYG----------------------PYF----E------------------- -------------G-------------------------------LAKAEPNH--------VLGKL------ -WGQRD---------------------------------------------------GNPTPTAD--L---- VDKVL----------R-E-------R-V-A-AMVPSLWSESFMADDFSK--------------YGDCRL--- -----TSFKSN--LVP------------------------------TS--------------------MTFA YPKN-S-P-------------------------LKNAMDLM-----------SLHVIETGLPDYLLKKKTWN AT-WCT-----------KTDNNLS-------------ES-------------R------------------- --------------------------ALTVTDFLGIFYVYG-------------IAL--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------DPYA- ------------------------------------------------------------------------ ----------------------------------------------------GGRGE--------------- -----------------------------------------------------CTIQSVET----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_018012552.1/1-533 PREDICTED: ionotropic receptor 21a-like [Hyalella azteca] ------------------------------------------------------MR---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------DLD------------------------------------------------ ------------------------------------------------------------------------ -------------------------DCVLL--------LIHD-ECNQ------------------------- --------------------DVADAIIQQ--EFLKE-----------------------------TPKAVFD LAHVG-------------------LEYK---------------STLSSRL-KSLKTSSC------------- ------VNYLI------LMRD--LKEGQ-------------------------------------------- -----------------------EML-----------HVL------------YEDR--ALDL---------- ----GAK-Y--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------VIGSS--------AI---------------------------- ---------TEQHTIAFFKSEPVDR----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------IKDVLLI----------------- ---------------------------------------------TPGSSHT-------------------- --------------------ILYLTTHQFFS-----------------------------------AT-ER- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------LKVSTFN------------------------------------------------- ----------Y------------------------------------------------PP--------VVI -----------------------------------------WN----------------------------- -----------PNAPT------------TSL-----------------------LSNSRSADGLE-I----- ------------RILNAIAD-K----------------------L----N----------F----------- ------------N----SWLRE-PNDG--------DQ-WGT------------------------------- -----------------------------QLSNG---------------S---W------------------ TG------------------------AIG---EV--------------SR-G--------------E---AD VSFA-----------------------------------------------------------NYFIT---- -RDK---LSS--V-----------DM-T-AL-----HSIDY---ACF-------------I-TPI------- --------------------------------PPP-PP--QYT-------------VLF------------- -----------------------------------IV--W-IGL-LLS-------LL-A---TV-----PLT SLIANY------------------------------------------------------------------ -------------------ETSNG------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------K----IFQ------------------------------ ---------------------------------NLGN-----CFMY---LWG--------IQLG---QPLE- --------E-KVL-PSSMSLRIAFVT------FGM-----ATFIVSVVYR---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------D----------------------------------SI-DP--------TSREI------ -YEGFQ----------------------------------------------------FVSGIDS--G---- IARVL----------H-G-------D-F-A-FMNSGRFLRYLVASNFTDV-------------YGQAK---- -----LHVTKEC-FVP------------------------------------------FR--------IGFA TPLF-S-V-------------------------YTGRFSEV-----------INRLVEAGLVTK-------- ---W---------------FNEIL-------------QE-------------AAQQQRLKARHELGGLGSSI T------------------EEPGASVVLGLYHLQGAFILLL-------------SGLCF-SFL----GFIGE LI---------------------------------SI----------------------------------- ------------------------------------------------------------------------ ---------------------------------T-------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------YV---RSRMRGNE------------ -------------------------------------------------------VK--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_018014568.1/1-689 PREDICTED: glutamate receptor ionotropic, delta-1-like [Hyalella azteca] ------------------------------------------------------MWR--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------LVL--------QLVLA-----------------AGA-------------- --------------------------------------LAAE-RVL-------------------------- --------------------ASVTY-----------QTQTWVQ------------------------CAALS A--------------------RDV-NKQAAL-----------TTLTTVLV---------------------- ------------------MCN--TSDLV-------------------------------------------- -----------------------RIF-----------QQV------------SRE---SLEH---------- -----RR-VWWA-V----------------------------------------------VGEDAGL----- ------------------------------------------------------------------------ ----PKLLQGL-------------------I----------------------------------------- ---------REGVQMALLV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------ADAA--------------------- -------------------GRYKFYVAEV-------------------------------------SPLLGM RMKLLDHPPVLCATPG-------------CSLP----PSV-------GTTHPK-------AVP--------- --------------------------------------------ALYNSS-QMDQN---------------- ------------------------LDELSYRKPD---E-L------YRNP-DEV----YRN----------- ----------FSNRL-LVIAALP------------------------------------------------- ---------TI-------------------------------------------------T--------FFN -----------------------------------------YT-----A----------------------- ------------DA-D-------------G--------------------------KLVPEGGVD-V----- ------------QIVATLAK-M----------------------L----N----------F----------- ------------R----YVISE-PTE---------RV-WGG------------------------------- -----------------------------PQKDG---------------N---I------------------ TG------------------------LVG---HV--------------AK-R--------------K---AH FSMC-----------------------------------------------------------KITIT---- -AER---AAV--V-----------DF-T-TA-----YFTEG---YAI-------------V-TAA------- --------------------------------PTI-VG--QSM-------------SILRP---FT------ ----------------------------------YPV--W-GLL-IAA-------VG-M---MG-----PIT FTITKV------------------------------------------------------------------ -------------------GHSII-TNVGQST---------------------------------------- ----HSASP------ASK--------------NTTDNPPH-----------------YGRP----------- ------------------------------------------------------------------------ ----------------------------------AKLG-VASSPSPSNGAKKQGFKSPVKP------LGLRK EEAPTR-GARSREWLPLG---------------TLPE-----FCFN---AFR--------SVV-----NQG- --------N-LIH-VGLDSVKVLFVF------WYI-----FCLIVIYLYSG-----SL-----TA-GYAVPT Y--SA-----------------------TID-----SLEQVVAAGRR------------------GQMVP-- -----------LMNFQ---------NSLDT----------------LF----K------------------- -------------S----------------------------------SP-PGS-------LYRAI------ -ADLY-----------VPGV-------------------------------------TYAFPVET--GA--R YEALK----------R-G-------G-Y-T-SFNSYGDARALT----LQ--------------AGRRY---- -----FHIGREL-FYF-QS-------------------------------------------------YGTV LPSG-A-P-------------------------YKGVFDDA-----------LLRIVEAGLPNR-------- ---F---------------LEERL-------------QQ-------------I---LGVKLYLQERSAAA-- ------------------GGGGLETSSISLRHTQGAFFVLL-------------GGCGV-GFL----SLVGE IF---------------------------------LN-RR-------A-MRQ-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_018016463.1/1-441 PREDICTED: glutamate receptor ionotropic, NMDA 3B-like [Hyalella azteca] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----MREW---------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------T------IPNS-PTGKSFEAFE----------- ----------PTPGC-ISVAV--------------------------------------------------- -----------------------------------------------------------TP--------WSQ ----------------------------A------------IV----------------------------- ---------------D-----------LSKKP----------------------------YTGAH-I----- ------------EIFRIMMQ-Y----------------------L--------------GW----------- ------------C----YYLVA-PADMS----------LGI------------------------------- -----------------------------LVNGS---------------Y---------------------- TG------------------------GVG---ML--------------AR-R--------------E---VD MLMG-----------------------------------------------------------PIVQH---- -PTR---SEL--V-----------EY---A-QAY-----------LYNT-HYF-------L-YKKIT----- -----------------------------KVQPDV---------------L-----IFTKP---FL------ ----------------------------------TDV--W-LWV-LAS-------VI-A---VG-----GTA GLLHL------------------------------------------------------------------- -------------------VHSYI------------------------------------------------ ---------------------------------------------------------RNSH----------- ------------------------------------------------------------------------ --------------------------------LKSKQ----------------------------------- ------------------------------------------SKWV---MFSRGLTWAWKTVL-----AQD- --------P-SDS-PGERSGRLLSTL------WLI-----NCFMIINMYQC-----NI-----TA-ILINDK V--KL-----------------------PFT-----SVEDFVTQKTYK--------------------LT-- -----------WINGQ----IYS----------------------SFF----Q------------------- -------------E-------------------------------YAVNQPDL--------PLGKL------ -WGMRD---------------------------------------------------DYQPDANH--V---- VSTVM----------T-E-------K-V-A-VVAARWLQRGFMAGDFSE--------------FGECRL--- -----ALAEANS-LPP------------------------------VY--------------------MTYG YPKN-S-P-------------------------LQVKVDIM-----------LLRVVQSGIAGNLLSNSLWN SS-WCM-----------RPQTSLS-------------DS-------------R------------------- --------------------------PLAVTDFLGLFAIYG-------------LGMIL-ALL----VF--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------IVEVA- ------------------------------------------------------------------------ ----------------------------------------------------TGR----------------- ------------------------------------------------------DFQSRKNE---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_018017676.1/1-557 PREDICTED: glutamate receptor 2-like [Hyalella azteca] ------------------------------------------------------MTSCG------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------PTVTSGHGSVDG----- ---------------------------------FLGSLPQ------------QQTSFI-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------GLQVEQQLLPNGL----DDARCFPAFKVAPNKWSFH------------- --SVSKRPVLV-------VHKG-ESDME--------------------K----------------------- -----------------------RCMYAX-----------------------------TLNNT-E------- --------RDWTAL--------RLV-----------------------------------VCSDDLL----- ------------------------------------------------------------------------ -------------------------SAVSSL-----------PW---------------------------- ---------PLNNRALILVPE--------------------------EV-------GLSAW----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------EAYRASAAVP------------------ ------------------AVYQRLSAVSV-------------------------P-----------PLQQQL SVLRREPW---------------------------------------------------------------- ------------------------------YR---------------------------------------- ----------------------------------------------------------RTN----------- ----------LTGLV-MRCLSED------------------------------------------------- ---------------------------------------------------------Y-PP--------FSM --------------------------------------TSPLP----------------------------- ---------------D----------------------------------------GTVTVSGFA-G----- ------------DVWSSLEQ-Q----------------------L----S----------F----------- ------------K----SECRN-PDD----RL------WGSLD----------------------------- -----------------------------ASTDR-------------------W------------------ DG------------------------ILG---QI--------------QR-G--------------D---SD IAVA-----------------------------------------------------------PYLVN---- -EIR---GRY--F-----------EF-S-VA-----LYSSW---ESV-------------I-VQK------- --------------------------------PASFSS---------SS-------NFTRE---FT------ ----------------------------------PAS--W-LAV------------------LG-----LLV TLMLTM------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------KIFS-----KCMH---SYR----------------YDG- --------N----KSERISHRIWLLT------ALL-----ACLLLNVAYSS-----NL-----TA-ILLSET N--EL-----------------------PIK-----TLQDIYDRR---------------------SEYS-- -----------LGLVG---------DTFAV---------------DLF----K------------------- -------------F----------------------------------AGDNDV-------LLRDL------ -WREVISK---DPRN--------------------------------------------IASEKA--N---- VERCL----------EDS-------K-HLA-IMDYHYYIDN----------------------FADCR---- -----LTVLPEK-VIT-AS-------------------------------------------------ISFP MRRN-H-P-------------------------ANPIINFE-----------LLKMSESGVLQKLLAR---- ---W---HG-----GGRACESELL------------------------------------------------ -------------------------HALGLAETYTAFVLLA-------------VGVTI-ASV----LLAVE NF---------------------------------T------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_018019213.1/1-430 PREDICTED: glutamate receptor ionotropic, kainate 5-like [Hyalella azteca] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------MKN----------- ----------FYGEK-FHISTLD------------------------------------------------- ----------F------------------------------------------------RP--------FTD -----------------------------------------FI----------------------------- -----------RQPNT---------------------------------------RVVKEAPSLD-I----- ------------YILREVAR-H----------------------L----N----------F----------- ------------T----YDIVT-PMD---------DL-WGT------------------------------- -----------------------------RLENG---------------S---W------------------ TG------------------------VVG---DV--------------QF-R--------------R---SN FSLV------------------------------------------------------------LSLT---- -MER---RLI--L-----------DF-T-RM-----YYTDP---LTF-------------V-TAK------- --------------------------------NRP-LP--QWQ-------------KVFEP---FA------ ----------------------------------NNV--W-LLW-GTT-------LG-T---CS-----VLY HGLRKL------------------------------------------------------------------ -------------------NPLIG------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------QR-----A------------------------------ ---------------------------------TFSQ-----SCLD---IFG--------SFL-----SQN- --------L-QRI-PSKTMTQVFIAT------WLI-----YGLLTTTYYKS-----AL-----MA-VLAVPT T--PP-----------------------TLN-----TLQELY-----------------------DSKIQ-- -----------YGMID---------AKGSEY--------------QLF----S------------------- -------------T----------------------------------SK-ID--------LYQKL------ -FQKMS----------------------------------------------------FYSSKES------- MRRVA----------E-G-------S-Y-A-YIYFRANIESIVMSEYTDR-------------AGQTY---- -----MHIAAEN-FFP------------------------------------------GG--------YAWA FPKG-A-P-------------------------YMRTIDQL-----------MQRCLQAGLVSR-------- ---W---------------VLQLN-------------KL-------------YAKEKHENSSTDD------- ----------------VLRPIDDGLVVLQMSHLQGPFILLV-------------MGLVL-GLT----SFIVE MA---------------------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------SCKRQKLL------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------EKKP---------------- -------------------------------------------------------VTSYRK----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_018021938.1/1-604 PREDICTED: glutamate receptor ionotropic, delta-2-like [Hyalella azteca] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------M-----------------PSN-------------- ------------------------------------------------------------------------ ----------------------------------------GQ-HKQP------------------------- --------------------------------------------------------------TKKESWVSIN HGS----------------------TIPTDVV----------HSSILSSAPLGLHVESS------------- ----SCGARVY------LISD-----LQ-------------------------------------------- -----------------------PLL-----------QLL-------------------------------- ----NGTDAAWDFDAWYV------------------------------------H----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------DAWYVHDAW----------------------------------YVHDA----------- ------------------------------------------------------------------------ ----------------------------------------------WYVHDAWYV----------------- ------------------------------------------------------------------------ ------------HDAWYVHDAWYVRDAW-YVHD--------------------------------------- ------SWYVRVLKSK---------------SP--GVPWIL-------VKHRVYRKDNHEIVPLDALV---- --------------------------------------------GEMSDD---------------------- ---------------------------LNLVKTS---A---------P-----------TD----------- ----------LMGVT-LTVATFE------------------------------------------------- ----------W------------------------------------------------NPS------VFYA -----------------------------------------L------------------------------ ------------DA-D-------------GRR--------------------------LPSYGMD-I----- ------------QVVKALAS-A----------------------L----N----------F----------- ------------S----IVFLEPPAG----EF------WGR------------------------------- ------------------------------QEGA---------------E---W------------------ TG------------------------MVG---MV--------------NS-T--------------R---AD LGVG-----------------------------------------------------------DLFLS---- -IDR---NHV--V-----------LY-S-TP-----YDVEF---SCF-------------M-AST------- --------------------------------TPP-LP---------------RWRSLTFP---FS------ ----------------------------------REA--W-MAV-GLGLLSLELALI-I---TT-----MLT PKLAEQ------------------------------------------------------------------ --------------------PTKK------------------------------------------------ ----------------------------------------------------------KQT----------- ------------------------------------------------------------------------ ---------------------------------------LQQ------------------------------ ---------------------------------TLIQ-----VF------------------------REP- --------V-NWT-PERHSSRLLLSV------VWL-----YVIVITVAYCS-----NL-----TA-FLTVTK I--PP-----------------------AFE-----TVKGLYDTGLL-VTSLG------------------- ---------------------------------------------DFF----K------------------- -------------DGLAS------------------------------AV-DP--------YLKSL------ ------------------AD-------------------------------------RF--VGHD--DLASA WPAVL----------K-G-------D-A-V-YLGNRNFLEYTLATYPCA-----------------NP---- ----CLRIMKEC-FAP------------------------------------------YS--------VALA LQRH-S-P-------------------------LKAAVDAR-----------LLRLIDSGLVRH-------- ---W---------------FLESLTI--------SRQTR------EF-----KAENQDTEKRSGEED----- -----------------------GPVPLSLDHISGAFFIHC-------------ILMLF-SLL----CFCAE -----------------------------------LC----------------------------------- ------------------------------------------------------------------------ ---------------------------------TAKALKNKKNKNIEKRT---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_018027085.1/1-749 PREDICTED: glutamate receptor ionotropic, delta-1-like [Hyalella azteca] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---MVQ------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------AALI-----------------PLA-------------- -------------------------------------------------------EVT-------------- --------------------------------------LISD-ESV-------------------------- -----------------------SEEGLT--EVLQLLKTATGG---------------------VTAVTTVD L------------------------SASSDT-----------GKLLGSLK-PRPGEPKF------------- ------KTFIA-------MVA--KTRIA-------------------------------------------- -----------------------ALQ-----------TTA------------RTV---GLMG---------- -----SK-NEWLFV----------------------------------------------VSDSNDM----- ------------------------------------------------------------------------ ----AEDMSPY----------------MADM----------------------------------------- ---------EDGDNLSFFY----NTSVAQPTQPCQDEFK-----------CVLGL-AVEQY-A--------- ----TQLSVTLEETLEIFHKVSEE------------------------------------------------ -EWA-EMKPTKAQRSEAIIKK---------------------------IKDAL------------------- -----------------------------------------------TSMSRCH------------------ -----------------RCTSWEAQAVEV-------------------------------------KDADRF ELLKSARW-----------------------------------------------------TPLTG------ --------------------------------------------VTVYDD---------------------- ---------------------------------------L------FPHV--------TGG----------- ----------FRGRR-IKVTSTD------------------------------------------------- ---------------------------------------------------------N-PP--------WHK -----------------------------------------FV----------------------------- -----------RDK-N-------------NTI--------------------------VGYTGLM-F----- ------------DILNEIGR-R----------------------L----N----------F----------- ------------T----YEVIP-PPE--------INK-FGV------------------------------- -----------------------------LE-NG---------------R---Y------------------ NG------------------------MMG---QI--------------TR-K--------------E---VL VGCG-----------------------------------------------------------AFTVT---- -NLR---KQV--V-----------DF-T-TV-----IDKQP---YTY-------------M-IAR------- --------------------------------PKE-LS--RVL-------------LFVEP---FT------ ----------------------------------SDT--W-ILI-AIA-------TL-L---MG-----PIL HLVNSH------------------------------------------------------------------ --------------------SPFY-A---------------------------------------------- ---------------------------------------Y-----------------YDLH----------- ------------------------------------------------------------------------ ----------------------------------RGRG-LF------------------------------- ---------------------------------TLQD-----CSWY---IFA--------SVL-----QQG- --------G-DRM-PMCHSARVALGF------WWV-----FVIIIVTTYSG-----NL-----VA-FLTFPK L--EN-----------------------AVQ-----TLDDLLAAR---------------------YSMS-- -----------WGYVG---------GGALQ---------------DYF----K------------------- -------------G----------------------------------A--EG--------KFKEI------ -GDLATIH---DRE-----------------------------------------------DQI---L---- LDRIR----------Y-T-------D-Y-A-YIQWKVNLLVIMKEEFLR--------------TDSCD---- -----FSLGREE-FYS-EH-------------------------------------------------VAMA MPKG-S-P-------------------------YVWKFDEE-----------IKLMLKGGLVQK-------- ---W---------------MQDHW-------------PK-------------K---DRCSASAYGDG----- ----------------------DGMRTVSLADMQGSFVLLG-------------LGFLL-ALV----FIIAE FV---------------------------------WR-C--------------------------------- ------------------------------------------------------------------------ ------------------------------------------AKPNLSG----------------------- -------------------------------------------------KGGS------------------- -----------------------------------------------------INSTVTTNRTNSNVNK--- -----NFSINNDDNRYDGNVKRN------------------NWYNI-------------------------- -----------DNGLNHGD----------------------------------QQGRS-------------- ---------------------------------------------------SISYVP--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------PQHLMRYYDHRS------------------------ >XP_018496709.1/1-786 PREDICTED: uncharacterized protein LOC108864855 [Galendromus occidentalis] ------------------------------------------------------MKAAEY------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------HEIDQKEASL ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------F-------PTIE------------- -----------------------------------------------------WDILS-------------- ---------I----------------------------KVTD------------------------------ -------------------ACDKRLNLLRMHSLVRAVASPFRGM---------------------------- --------------------CNLGNEDAKRI--------------------RNLTKRDC---------A--- ------SAVLT------------LQHAS--------------------REGL-------------------- -----------------------HFV----------NRKSFDS---------DDSFT-PLYNVVGYNV---- --------PPQLVIDA-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------LDEYSFLQRH-------VDF---------------------------- GCFVSVD-RAERLNEALVT-------------------------------------SIDVI----------- ---------------------------------------------------------------CC------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------QALFIYDMMS-----------------------------------LDSDVI QQSLIESL-------------------------------------------------VVKASGYKFGV---- --------------------------------------------FILSRS------------------AK-- --------RVC--------------------------S-MCGV---------------ARS--VIAG-YDFT ----------FDAPERLEISFVN------------------------------------------------- ---------------------------------------------------C-------TP-------HFIV -------------------G---------------------LE----------------------------- ---------------N-----------STG------------------------VTRYFPLHGTE-T----- ------------WLLNDSAT-Y----------------------L----N----------F----------- ------------S----YRLTE-----------NREKVWGS------------------------------- -----------------------------LSGKG------------RNRS---W------------------ NG------------------------MVG---DV----------F---AR----------------T---VD LAVT-----------------------------------------------------------EISNT---- -YAR---SQA--I-----------QY-T------RMFVWEK---SLF-------------V-SKK------- ----------------------------GSQIPSA---------------S-----ALWWPLDRLS------ ---------------------------------------W-FLT-LAS-------LI-F---YS-----LAA AALVRF------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------Y---------------DKTSIP----------- ------------------------------------------------------------------------ --------------------------------QLSRDNIVLP------------------------------ ---------------------------------KFRKLPP--ADFFM--LVS--------TLA-----RQSH L--GYRE-------YETLSYKVFMTW------WWI-----FVLIMTNVYSS-----LI-----LS-FMSVPV F--QP-----------------------GVD-----TFDELLREMKA-------------------GRMT-- -----------AGAQKTS------FGSAIL---------------QTY---DK-------PV---------- ------------------------------------------------AE----------YIEANF------ -----------------------------------------------FGP-------EWFPEERAK-G---- VSMAA----------DDS--I----N-Y-A-FVDMQNFVTAIIRANNWQHK--------------------- -----LQLSKSY-FSV-TG-------------------------------------------------SSWV LQKR-C-----------F---------------MLSHFNDF-----------IRREMEGGLIAL-------- ---Y---------------LDRAL------AAG-SQGKK--------------------------------- --------------------IVKVAEAIDFSDVFSHYCLIGYIAQFIGERGGTKLGLKISGAL----SYAAE KI---------NNSTELLGDDKVEII---------YKDERGDPI-----RATRLVVDMYNANVSMI------ VGPENFCKYEAHV----ATAVRLP------------------IFSYG------------------------- --------------------------------NRILSLADEATSMKLNELF--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----FSVKFRDPSNS---------------------------------------------------L---- ----------------------------------------------------EEETDSSATQ---------- ----------------------------------------------INLSVRNPLLEEVDIP---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_022241902.1/1-852 ionotropic receptor 93a-like [Limulus polyphemus] ------------------------------------------------------------------------ ------------------------------------------------------MLSFSTAIF--------- ------------------------------------------------------------------------ ---IG-----------------------------------------------------------------TT EE-------------------TTQLYI--------------------------------------------- -----------NNKLQQIEHEVSDSF-------QRVNQSLEFIYKW-------NFDV-----AGVNPGLLEA --QGL-TPNL--LVVII--SFLSCVSTSKLSNILKSS-FPEVLHVALHL----------------------- --------------------------------------------------------------------HPCP R----------------------------LLRDQAIEI-----------------PDMKSFS---------- ---------------------NLLY--------MMQDLR--TNSLRD------WEDII-------------- --------------------------------------FLHD-SCI-------------------------- -----------------------DVNTLE--SVVKNFVLSENGTQ-------------------MTAVTTYE LSEDHF---------------------SLSL-----------RTIFSEIL-SSYTKF--------------- ------RYFVV-------VGQ--DFALR-------------------------------------------- -----------------------AVL-----------KEA------------QSM---DLLN---------- -----MY-RFWIFI--------------------------------------------------NPF----- ------------------------------------------------------------------------ ----ASFPEQMW-------------SSFSII----------------------------------------- ---------PDKANVVSVYPE-DNLDFSKH--SSIDKAK-----------KRVDL-VLNNM-N--------- ----KVIKDMLQTKQLNIATPTA------------------------------------------------- ----------RQTTQAMAKEK---------------------------FLNYM------------------- -----------------------------------------------EKNN--------------------- -----------------IYENYVIESVDA-------------------------------F--RSSPEETVN KMVKIGEW-----------------------------------------------------NLLRG------ --------------------------------------------LRLNNE-------C-------------- ---------------------------------------L------FEKK--------TLN----------- ----------LGGQL-LKIGIVN------------------------------------------------- ---------------------------------------------------------D-PP--------LVI -----------------------------------------TK----------------------------- -----------NKQ-T------------KTSV--------------------------VEAKGIS-V----- ------------DLLNAIAV-K----------------------L----N----------F----------- ------------T----YTFVM-SND---------GI-FGS------------------------------- -----------------------------LGENG---------------E---W------------------ KG------------------------LIG---MV--------------LN-K--------------E---VN LAAV-----------------------------------------------------------GFSVT---- -PQR---SKV--V-----------DF-T-NS-----IDEDP---YVI-------------L-VKR------- --------------------------------PSK--D--NHL-------------LVLAP---FT------ ----------------------------------WET--Y-LCI-ICS-------VV-I---IS-----PVL HLINRY------------------------------------------------------------------ --------------------SKYY-E---------------------------------------------- ---------------------------------------Y-----------------HQLV----------- ------------------------------------------------------------------------ ----------------------------------NNKG-LF------------------------------- ---------------------------------QLSN-----CYWY---CFG--------SLI-----LQG- --------G-VHL-PKAASGRVLISF------WWF-----FVIIVVTTYSG-----SL-----VA-FLTFPK L--HN-----------------------PVN-----SLQDILDQK---------------------QYLK-- -----------WGVFE---------GEAII---------------EYL----K------------------- -------------Y----------------------------------AP-SG--------GLKEL------ -NNGLNFF---KYT-----------------------------------------------DEAE--V---- LRQVR----------D-E-------N-F-V-LIGAKSRLMAIIKRELSR--------------TKKCE---- -----YILGKEN-ILY-ES-------------------------------------------------LSMA VPEN-W-P-------------------------YLDEFNEE-----------IARYMESGLIMK-------- ---W---------------RSNYY-------------SE-------------E---NQCTMISKPQA----- ----------------------GDTRVIGITHLTACLYVLG-------------IGFST-SLC----FLIIE LI---------------------------------YV-AY-------I-KSMNNA----------------- -------------------YCS-------------------------------------------------- ------------------------------------------------------------------------ --GCTSLQRL------IILNNLRRKIYPSIRPQ--------------------------------------- -----------------------------------------------------RDQSL-FSK---------- -----RFASQEGRM---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_022243873.1/1-467 glutamate receptor ionotropic, delta-1-like [Limulus polyphemus] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------MIMSSTMA--AIEEGSLLNT-SFFVK------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------PRL------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------N----------- ----------LHNRT-LQIASVH------------------------------------------------- ---------------------------------------------------------R-VP--------FQN -----------------------------------------IT-----T----------------------- ------------LP-N-------------GGY---------------------------QASGFI-F----- ------------EIVNHLAH-Y----------------------F----N----------F----------- ------------S----YNIVI-PED---------NS-FGKLV----------------------------- -----------------------------KHENG---------------TE-SW------------------ NG------------------------MMR---LL--------------LD-K--------------K---VD LAAG-----------------------------------------------------------PFTVN---- -VDR---RRV--V-----------NF-S-ET-----LFSDD---IGV-------------L-VKK------- --------------------------------PEK-KD--NTE-------------KLLAP---FT------ ----------------------------------LRV--W-CAI-ILA-------TI-F---MG-----LTL FGVLCL------------------------------------------------------------------ --------------------QTYL-L---------------------------------------------- --------------------------------------CS-----------------GEES----------- ------------------------------------------------------------------------ ----------------------------------GEKY-NY------------------------------- ---------------------------------SLSK-----CMWF---VYS--------GLV-----KQG- --------A-EDV-PISDSVRILFAT------WWM-----FTLLVTAFYTG-----NL-----TA-FLTSSV Y--KL------------------------GN-----SLESVLN-D---------------------PTTK-- -----------WLVDY---------GSALD---------------SAI----E------------------- -------------F----------------------------------PT-DT--------SFRQL------ -HASRLKG---KCD--------------------------------------------TTEGDDE--A---- VILVE----------K-G-------G-Y-I-FFREVNVLNYLIRRSFRK-------------HRGKCV---- -----LTKGWVT-FYR-RQ-------------------------------------------------NAIP YAPD-S-L-------------------------YAEDFNLM-----------IKQLRAAGLIEK-------- ---W---------------KEQYF-------------PN-------------M---ESCFLSRSKSFN---- ----------------------TQEEALSVFELASAFYLYS-------------GGVAL-GIA----VLIIE NV---------------------------------WR----------------------------------- ------------------------------------------------------------------------ ---------------------------------------NIFGNNKNDSK---------------------- ------------------------------------------------------------------------ -------------------------------------------------------------MA--AW----- -----------L------------------------------------------------------------ -----------------------------------------------------KR----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_022249177.1/1-541 glutamate receptor-like [Limulus polyphemus] ------------------------------------------------------MKALA------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------SLTPPDHTILFRP-TKKLII------------------W------------------ ---------------------------------------IPD-SQ--------------------------- ---------------------------------------------------------------------TFS ADLQQLK----------------------------------------------------------------- -----------------------ANYIM-------------------------------------------- ---------------------SVKTV----------VVIL-----------LVKVY--RLQER--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------ILK---EA---------------------------- ---------TEGDNVLLL------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------IEEKRHLT------------------ ---------------------YSLVKLQW-------------------------------------SPNGKG FFTAPCTW---------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------SFEGKHC---RNV-----I------KTRQ--------LRK----------- ----------FQGRL-FSVT---------------------------------------------------- -----------------------------------------------------------YP----------- ---------------------------------------RGLE----------------------------- ---------------D------------------------------------AP-------KRFI-F----- ------------QILDTLAK-Y----------------------Y----D----------F----------- ------------T----YVVRE-PLG---------ET-YGF------------------------------- -----------------------------QDSNG---------------T---W------------------ KG------------------------IVG---QL--------------VR-K--------------E---RD IGLA-----------------------------------------------------------LLSWT---- -LER---ESA--I-----------DY-V-KC-----ISVDD---VTF-------------I-SKR------- --------------------------------SSAERP---------FG-------ALLFL---FK------ ----------------------------------AEI--W-ILYVFCG-------IV-----AG-----MAM SLTNWFK----------------------------------------------------------------- -----------------YT------KMNRG------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------TKTT-IKQ------------------------------ ---------------------------------SWKT----NVWWL---VLR--------TGM-----LQG- ---S------PST-PKQNMTRIILAS------WWL-----VCIVILCLYSG-----NI-----LA-FLSIKK I--ES-----------------------PLD-----NMKEVHMKPRI------------------------- ---------GVLAIPG---------S--PT---------------FTF----M------------------- ------------------------------------------------ST-TNIT------TFSNV------ WKRNTQSKV-----------------------------------------------DP-RLPNDE--Y---- LEKVK----------Q-GN---ILVGLR-H-WLN----LISNPKDNEKQ----------------TCSI--- -----FHIASEN-IL------------------LDF--------------------------------QSFG LHKG-S-I-------------------------LTYPLSEG-----------VDWLRRMGLIDF-------- ---W---------------NHKYF------------------------QSMETHLTGDCAR---TNEQ---- -------------------------LPLFIEDFGMAFVLLL-------------CGYFL-GTI----TLCFE F---------------------------------GLS-CY---------NKHR------------------- ------------------------------------------------------------------------ -----------------------------------ETWK--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_022255648.1/1-744 glutamate receptor 2-like [Limulus polyphemus] ------------------------------------------------------MGPLTEA--QIENHILVV YNNGTGYFPA--------HKV----------------------------MSQ-LDMSFLVFVFRVSEIGALC ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------NYGKKEKVLTLSQKVDVIAAGKQPG---------VTRQQFGV--------- -----------------------------------------------------SRQIV-------------- ------------------------------------NLIWMQKSDLESRFQSGQGNAN-------------- ----------------KKRNSPGTFSELE--EIIFLWFKEKRAQGVLP--SGVLLRQKAVDLAQTTKIEGFQ QND--------------------------------------GVRLRKIIASTSVRLREIIASTSVRLREIIA STSVRLREIIA------------STSVR-------------------------------------------- ---------------------LREII---------ASTSV-----RLREIIASTSV--RLRKIIAPINLLKK KSILSGK-TKLVLVVKE-------------------------------------------DLRKDIMDTVT- ------------------------------------------------------------------------ -------------------------EGDKLLLIT-------------------------------------- ---------EKSQNKSNSS-------------------------------------------S--------- ----------------------------------------F------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------LTEFLIWKND---GS--------------------------------------- -----ATF---------------------------------------------------------------- -----------------------------------------------------------------------T N----------------------------------------------------------------------- --------------A-RDDEII-------------------------------------------------- ----------------------------------------------------------FPPS------TNNF ------------------------------------------------------------------------ ----------------------------GGRT-------------------FLATLLTKNNDKLA-I----- ------------QVLNILSQ-V----------------------L----N----------F----------- ------------S----LAFPDPPAD------------SYG------------------------------- -----------------------------TKDYA--------------GV---W------------------ GG------------------------AVG---QL--------------AR-K--------------E---RD VA-------------------------------------------------------------GIQLS-WT- -AER-------NAVI---------DFA------------EF---YQL------------AALMFG------- --------------------------------SRAPRQ-FPRSG------------ALFRL---FG------ ----------------------------------VEV--W-VAY-FFA-------SL-L---SG--GIVAAT WMFYLF------------------------------------------------------------------ -----------------------------------------------------------KI----------- -----------------------------------------------------------NP----------- ------------------------------------------------------------------------ --------------------------------KEGATS---------------------------------- ---------------------------------SFSI-----LQLSLEASLK--------ISL--WQGVEK- ------L-------PSNIGSRIVFAI------WAV-----ACLIVLSVYCG-----NI-----RA-FLSIKE T--EQ-----------------------PLD-----TVAQVLKGNVPAYYYPG------------------- -----------TSTES----FLRETSFSLVHE-------------LWK----K------------------- ---------------------------------------------------NK--------N---------- -----NNKE------------------------------------------------RMNPNQ-Y------- LDLMS----------N-GG----------I-LLATNVNLEKLFQQFEESS-------------GRSCPFYLG -----KQRLKEDYLC-------------------------------------------------------LG LQKN-S-P-------------------------FLEPMSYR-----------IRDFKRGGIIQ-F------- ---WQE-------RI--------I-------------EEQ------------VIKEGSCDPRLRSNKDQTNI ------------------------LLSLSLNDVIVSFQLLL-------------SGYVM-SIV----TFCVE YL---------------------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------IGRFKINQNVPK-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_022258100.1/1-401 ionotropic receptor 25a-like [Limulus polyphemus] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MILA-----------------------------------------------------------ALSMT---- -AER---TEV--V-----------DF-V-TPY----FDQTG---IAI-------------L-GRK------- --------------------------------PEK-QK--SLFK-------------FMEV---LK------ ----------------------------------PEV--W-WGV-LGG-------IV-A---TG-----LCL WILDRY------------------------------------------------------------------ --------------------SPYS-NRN-------------------------------------------- -----N------------------------------KQSY-----------------S-------------- ------------------------------------------------------------------------ ----------------------------------QPCR-EF------------------------------- ---------------------------------NLKE-----SFWF---VLT--------SFT-----PQG- --------GGEV--PKSLSGRVLVAG------YWL-----FVVLILATFTA-----NL-----AA-LLTVER M--QI-----------------------YVR-----SLEEMAQRV----------------------DFN-- -----------FTVIE---------SSSSK---------------QYF----I------------------- -------------NMAEAEEELYHAWKNITLN---SGRETGKFRVWDYPI-KE--------QYKNI------ -LKIIERS---QP----------------------------------------------VSKVQE--G---- VKRVKENTNG-----Q-----------F-A-LLTDSPKVRY--------------------LVNEDCD---- -----FTMIGEP-FAE-HP-------------------------------------------------YGIA VTKG-S-T-------------------------LLEELNEK-----------VMQLQRQRFFED-------- ---R---------------ISKYW-------------NS-------------T-KRRICDALDN-------- ------------------------SDSLTVYDLGGVFIVTL-------------VGLVI-ALL----ALSLE VW---------------------------------HF-SK-------K-NKSRI------------------ ------------------------------------------------------------------------ -----------------------------------QATTV-TLSKKEN------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------IFTVL---RKEAWATSP---CV------ ---------------------------------------------------KD------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_023215761.1/1-870 ionotropic receptor 93a-like [Centruroides sculpturatus] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---MA-----------------------------------------------------------------MT H----------------------YGVIVD------------------------------------------- -HGITVGG---DNVFDTLDELTSDLE-------QRMGESVQI--NWLGKRAIHIND--------LKME---- ------SKGK-DLTAVL--TMVDCRLAQETVSIMEKKDFQTVLYMSIMA----------------------- --------------------------------------------------------------------RDCS R----------------------------PPKNYGFGF-----------------PFIKTDTEKN------- -------------------YIDIVP--------LLKDLR--MECLAR------WNDVI-------------- --------------------------------------LIHD-NTI-------------------------- -----------------------GIDYLE--SIVSVFMEPGYSVR-------------------AASITSFD LCEESQ----SCT------------ESYEVM-----------VTILDSFK-HDEYKN--------------- -------NYLL-------IAG--KESVT-------------------------------------------- -----------------------KSL-----------KMM------------KRQ---NMLT---------- -----KS-KMWLVI----------------------------------------------LTDEPPY----- ------------------------------------------------------------------------ ----IDLENE-----------------IDNL----------------------------------------- ---------PVESNVAFAY-----KSTKDE--ECPTESG-----------CQVKV-AMTAF-A--------- ----DAVGKLKKENKFKMSNANE------------------------------------------------- ----------KAQTKNSLLTS---------------------------IKENL------------------- -----------------------------------------------KETTECG------------------ -----------------GCIKFIIKTSGA-------------------------------HHVSTKQKGYLG KFQTIGEW-----------------------------------------------------SPYKG------ --------------------------------------------IEMTND---------------------- ---------------------------------------L------FPSA--------SGN----------- ----------FRGKK-INIGVLH------------------------------------------------- ---------------------------------------------------------S-PP--------IAI -----------------------------------------VE----------------------------- -----------SSR-K--------------------------------------------VRGVV-A----- ------------ELVKELGK-T----------------------L----N----------F----------- ------------T----CNWVV-QRD---------RQ-FGT------------------------------- -----------------------------RQSNG---------------D---W------------------ SG------------------------LIG---AI--------------LK-K--------------E---IE FAAQ-----------------------------------------------------------AFYMT---- -EDR---LQV--V-----------NF-T-TP-----IIDDP---YAI-------------L-MRR------- --------------------------------PNL--A--HDY-------------LFLAP---FT------ ----------------------------------FDT--W-VCV-AIA-------VF-V---IG-----PIL NIIHRC------------------------------------------------------------------ --------------------SKYY-E---------------------------------------------- ---------------------------------------Y-----------------NDMA----------- ------------------------------------------------------------------------ ----------------------------------DGKG-LF------------------------------- ---------------------------------TLSN-----CAWY---CYG--------ALV-----QQG- --------G-NHL-PAALSGRILVGF------WWL-----FVIVTVTTYSG-----NL-----VA-VLTFPK I--RN-----------------------PID-----SVDDMLS-Y---------------------GRLR-- -----------WGTYE---------GEALI---------------EYL----K------------------- -------------N----------------------------------AR-TK--------QMQKL------ -NKGLQIY---KRD-----------------------------------------------DYEM--I---- LKKVL----------N-S-------R-F-V-FLAGKSELIEIQSKHHNE--------------TKKCR---- -----FSISNND-VLR-ES-------------------------------------------------ASIP VPKN-W-P-------------------------YLTRVNEE-----------IRRYIESGLLTR-------- ---W---------------FRSHL-------------PP-------------D---NECTVVSKPQA----- ----------------------GDTRKIDVEQMLGSFYLLG-------------LGCLF-ALI----AFICE IT---------------------------------YR-K--------------------------------- --------------------CL-------------------------------------------------- -------------------------------------KRKEKAAEPGQK----------------------- ----SDVN---------------------------------------------------------------- -----------------------------------------------------KKNMGFFG----------- ------RRPQNSPFL--------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------NPPDLIKRDDKIDDKTR----- ------------------------------------------------------------------------ ----------------------------------------LMSAESRHQPP--------------------- ----------------------------------DRPTYFSYGSRY-------------------------- >XP_023221674.1/1-659 glutamate receptor ionotropic, delta-2-like isoform X1 [Centruroides sculpturatus] ------------------------------------------------------MQSIMKHP---------- -----------------------------------------------------LWILIITSYLQL------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------NSTMEEETINFRE-AIISVVLKNG--------------WKNI--------------- --------------------------------------MIIN-GLENVTD---------------------- -------------------------------SLVSSLFNV------------------------GLSTTVIN ADRVQQYG---------------HFPSRKKLIRDF------------------------------------- ------NGYLL------VT-----KTEK-------------------------------------------- ---------------------SLEII----------TRQL-----------KVKRR--VINAR--------- --------RKWF------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------LAALFTTGKPNL---EL---------------------------- ---------KEGDNVLFLR----------------------------------------------------- ----KKLA---------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------EYEENKLLCPNQIN------------- -------------ETGGIEEIYTLYSLYS-------------------------------------TGGGDI FFCKIGYW---------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------NQKLH--LFHDNS-----I------YYPH--------FKN----------- ----------FRNRT-LNITSLG------------------------------------------------- ---------------------------------------------------------R-YP----------- -----------------------------------------VR----------------------------- ---------------E------------------------------------EPTGNDPRWKGCM-F----- ------------EAVNILAD-H----------------------Y----N----------F----------- ------------S----YIVYD-PPD---------KM-YALPI----------------------------- -----------------------------NGSKA---------------D---W------------------ KG------------------------LIG---EL--------------TT-Q--------------R---AD MAVA-----------------------------------------------------------DLSWS---- -PDR---AAA--V-----------DF-T-HK-----LFDET---LTF-------------I-YRA------- --------------------------------PNFLTR---------AW-------ILFEP---YS------ ----------------------------------KQM--W-MALGLTA-------IL-----IS-----LTL FFITCLD----------------------------------------------------------------- --------------------VCL--LQN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------TKVE-V-L------------------------------ ---------------------------------NLLY----WAIEA---TFR--------IMV-----TQG- ---S------DTL-PIMITGRIIVGT------WLL-----SMVIFVAIYSG-----NL-----TY-SLSFHK T--DK-----------------------PVD-----NLKEMVSKYSS------------------------- ---------AKLAVRY---------GSLPH---------------SYF----M------------------- -------------------------------------------------E-DNWI-------YKDV------ WKNNMEQNV-----------------------------------------------VPGDILDQE--I---- MNLV-------------------RNSSY-V-WISERTILQYEMIEASVN--------------HTFCE---- -----FYVSKAN-IL------------------HTD--------------------------------WAIA LQKD-S-P-------------------------FLQQFNKK-----------IKWMRYSGLVK--------- ---------------------KWK------------------------KHYWTKKRQGCVSTDGINRQE--- ------------------------LVPVTLDDTEAVFFLLA-------------GGFLL-SFV----VFLSE IIV------------------------------FRIS-KF---------QSLPLE----------------- ------------------------------------------------------------------------ ---------------------------------KLNTIKRQLTKQ--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_023225694.1/1-428 glutamate receptor ionotropic, delta-2-like [Centruroides sculpturatus] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MFD NQ---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------PSI------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------N----------- ----------LNGSL-LKVASMT------------------------------------------------- ---------------------------------------------------------R-EP--------YQK -----------------------------------------VNC--CMK----------------------- ------------KC-T-------------GE-------------------------------GFS-F----- ------------EIINKMAE-Y----------------------F----N----------F----------- ------------T----YEIII-PIH---------KV-YGS------------------------------- -----------------------------KLPNG---------------T---W------------------ IG------------------------IIG---ML--------------AN-N--------------E---AD IAAI-----------------------------------------------------------PLTVI---- -QER---KEV--A-----------VF-S-TT-----LFKDS---INI-------------L-MKQ------- --------------------------------PSA-SG--NAG-------------ALLSP---FN------ ----------------------------------LYV--W-IIL-IVF-------SI-L---MG-----PLV YLLQHI------------------------------------------------------------------ --------------------HYKL-I---------------------------------------------- --------------------------------------IV-----------------EEEP----------- ------------------------------------------------------------------------ ----------------------------------DKRN-DY------------------------------- ---------------------------------KLIE-----CFWF---VYS--------ALI-----RQG- --------S-ELN-PSYDSTRILFAA------WWL-----FTLVITTFYTA-----NL-----TA-FLSLET Y--AV------------------------EK-----DLHGILD-H---------------------TDKK-- -----------WIARN---------GSALY---------------INT----L------------------- -------------K----------------------------------GE-EP--------IFSIL------ -KKSLNEN---RGL--------------------------------------------FLTEDNK--I---- LQLVL----------E-K-------D-Y-V-FLQNSFALNFIAQRELMK-------------HN-KCM---- -----FVTTGFK-FFK-NS-------------------------------------------------YSFA FSKT-N-K-------------------------YINEFNHF-----------FQLITRTGLLSK-------- ---W---------------IIQHL-------------IP-------------A---HTCTLSSATGYN---- ----------------------SFELALSLRDIIGAFIVYL-------------IGMAV-SIV----AFLME KI---------------------------------W------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------KREK--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_023227043.1/1-479 glutamate receptor ionotropic, kainate 5-like [Centruroides sculpturatus] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------ME--ALSLLLFLN--------------------------VIRLLT AQ---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------YKNYSYST----LCSV--------------------------------------------- ------------------------------------------------------------------------ --------PKS------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------D----------- ----------FNSKT-LKVTSIS------------------------------------------------- ---------------------------------------------------------K-SDE------VFYN -----------------------------------------CT-----E----------------------- ------------SC-E-------------VF-------------------------------RFS-F----- ------------AAIDFLAE-V----------------------F----N----------F----------- ------------S----YQVIK-PED---------NT-FGIK------------------------------ -----------------------------EIING---------------TV-VW------------------ NG------------------------MIK---ML--------------AN-G--------------E---AD LAAG-----------------------------------------------------------LFFIT---- -EER---KEV--I-----------DF-S-LP-----IINDR---MGL-------------I-TLS------- --------------------------------PKE-AG--NYK-------------ALYAP---FD------ ----------------------------------RNV--W-IIL-IIT-------SF-I---MV-----PII YGCLRM------------------------------------------------------------------ --------------------DRYM------------------------------------------------ ---------------------------------------------------------RNDT----------- ------------------------------------------------------------------------ ----------------------------------SPEH-YF------------------------------- ---------------------------------TFRD-----CIWF---VFS--------GLV-----KQG- --------T-PRL-PQFNLARMLFAT------WWF-----FTLLLTSIYSA-----KL-----AA-YLTLPS F--HI------------------------IE-----NLDAVLE-N---------------------PSLK-- -----------WIIQY---------GHAID---------------GLI----Q------------------- -------------N----------------------------------PT-SS--------VFQKL------ -QTSMKKG---FGI--------------------------------------------KVNSTEE--A---- MALVL----------K-G-------G-Y-V-YIQEVTSLKQIMLDDYTK-------------TG-RCR---- -----FIRSSYE-FFD-NK-------------------------------------------------LAFG FAKG-N-N-------------------------YSQHLNAL-----------IYCLKAAGLIQK-------- ---W---------------NQRYL-------------VI-------------P---DVCRLSSDLFLR---- ----------------------AEDKKLNLLNLSPAFYLLA-------------AGLSL-GFI----TLLCE -I---------------------------------F------------------------------------ ------------------------------------------------------------------------ ----------------------------------------IFSRKKSSVR---------------------- ------------------------------------------------------------------------ -------------------------------------------------------------SQ--SY----- --------TVNI------------------------------------------------------------ -----------------------------------------------------KRSNK-------------- ---------------------------------TGSEKNVN------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_023232714.1/1-705 uncharacterized protein LOC111632512 [Centruroides sculpturatus] ------------------------------------------------------MIAVT------------- -----------------------------------------------------SATTLFSILILSPSIAIIN E----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------KNSWNNFLSS-------IFHHLK--------------WKFVI-------------- --------------------------------------FLVE-NRTDIK----------------------- ------------------------------------------------------EEIIVQLHDSHKSSVVIS VA---------------------------------------------------------------------- ----REGLVQVPTSLDFLYEE--EKSIK-------------------------------------------- -----------------------AVVDVNLGTFKTFLRKINKHP----MLWSSDS----------------- ---------YWLI------------------------------------------------KSENLW----- ----------------------------------------------------------------------FL K-----------------------DRNFSNL------------I---------------------------- ---------NKEINIAFTVFN--NTKET-----------------F----------LIYSL----------- --------------------------------------------------------------NCE------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------ENVGPL SFNVID-W---------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------NKNASNEK---S-I------FYKK-P----RYVKD----------- ----------LKGKK-FKFALEK------------------------------------------------- ---------------------------------------------------------H-FP--------FYL PP---------------------------------------------------------------------- ---------------KNI--------------------------------------KFPKPSGID-I----- ------------YLLDILSR-R----------------------L----N----------F----------- ------------S----YDIVR-PAD---------KK-WGSKH----------------------------- --------------------------------NG---------------T---W------------------ NG------------------------MIG---MI--------------EK-Q--------------E---VR GALG-----------------------------------------------------------GMSVI---- -ASR---VEV--A-----------DF-S-KS-----YAFDR---IAF-------------V-IRS------- --------------------------------PEE-TS--RKW-------------VIFRP---FT------ ----------------------------------WDV--W-LAV-TIA-------IL-V---VA-----ICL FVIENII----------------------------------------------------------------- -------------------WHSAE------------------------------------------------ --------------------------------------IYK------------------------------- ------------------------------------------------------------------------ ----------------------------------SRYD------------------------V--------- ---------------------------------KLKNLKIVKAILL---IYK--------SVV-----YQD- --------CYD---PTSNSGRVLIVF------WWI-----FVITLIAGYSG-----TL-----VS-FMANPG R--ET-----------------------PVD-----TISKLVSVLKS-------------------GQFS-- -----------CGTIS---------DSASH---------------EIF----R------------------- --------------------------------------------------------------FKTF------ -LRKINKH---PMLWSSDSY-------------------------------------WLIKS--E--N---- LWFLK---------DR---------N-F-SNLINKEINIAFTV----------------------------- -----FNNTKET-FLI-YSLNCEENVGPLSFNVIDWNKNASNEKSIFYKKPRYVKDLKGKK-------FKFA LEKH-F-PFYLPPKNIKFPKPSGIDIYLLDILSRRLNFSYD-----------IVRPADK----K-------- ---WGSKHN-----GTWNGMIGMI-------------EKQEVRG--------ALGGM--SVIASR------- ---------------------------VEVADFSKSYAFDR-------------IAFVI------------- -----------------------------------------------R-SPEETSRKW-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------VIFRPFTWDYNAFEIY------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------GHHRS------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_023241501.1/1-526 glutamate receptor U1-like [Centruroides sculpturatus] ------------------------------------------------------------------------ ------------------------------------------------------------MAVVRYQMG--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------ENVTS-------IISDLAK-MNSAQILL-LCDWKATK-------------- --------------------------------------FIIH-RMLGI------------------------ -------------------------------------------------------------------SVLWK ------------------------------------------------------------------------ ----RRNVFLI------EFQE--ENRIE-------------------------------------------- -----------------------EL----------------------------------------------- ---------------------------------------------------------------RNLI----- ----------------------------------------------------------------------F- -------------------------RDSNLL-----------FF---------------------------- ---------NGNSTEILKLVY--NGK------------------------------INKTL----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---II------------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------KLNVSESK---TEA------FCPD-GAVSRSGIGS----------- ----------LDGRT-IKVALQP------------------------------------------------- ---------------------------------------------------------H-FP--------FYS RE---------------------------------------------------------------------- ---------------S------------------------------------------EKNSGVD-I----- ------------KLLDILSE-Y----------------------L----N----------F----------- ------------T----YKIRH-SLD---------GV-WGTFN----------------------------- ------------------------------------------------------------------------ DG------------------------MIG---MI--------------RR-E--------------E---VD LAMA-----------------------------------------------------------GMTVT---- -SER---SAA--A-----------DF-S-LA-----YAFDR---TVF-------------V-TRA------- --------------------------------PGQ-KS--KTW-------------AIFLP---FA------ ----------------------------------RKT--W-MAI-AVT-------IV-L---MT-----FVL SLVENGI----------------------------------------------------------------- -------------------FPSV------------------------------------------------- ---------------------------------------WR------------------------------- ------------------------------------------------------------------------ ----------------------------------TKPK------------------------L--------- ---------------------------------TLYN-----SFFW---IYR--------AVI-----NQG- --------CYA---AISTRTRIVVSC------WWL-----YVLVVSTYYTA-----KL-----MS-YLTNPG L--EQ-----------------------PVD-----TVPKLIELLKA-------------------GTYT-- -----------CGTIK---------SSSDY---------------ALF----K------------------- -------------N----------------------------------HS-N-----------PVI------ -LETMN----------SDSS-------------------------------------NFVKHDVE--G---- LKKCL---------EK---------N-Y-A-YIAGELTIKADIRYE-------------------------- ---SKFLFSKDT-FRV-FG-------------------------------------------------YGIA LSKR-F--------------------------WHRQSFDHV-----------IIRLFEAGIIDK-------- ---W---------------IHSLI-------------DKKRM-----------------QTID-EDR----- ------------------------QNPLCLSDLQSVFILFI-------------IGLII-AII----IFIIE IC----------------------------------------------------HRK--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------RTKLC---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_023331754.1/1-433 ionotropic receptor 21a-like [Eurytemora affinis] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------M------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------YLLMMKP-------------WHILE-------------- --------------------------------------FLSA------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----KTNIILP-----------SESVL-------------------------------------------- -----------------------AVF---------------------------------------------- ------------------------------------------------------------QEDQSEV----- ------------------------------------------------------------------------ ---------------------------QEFFRNP--------VI---------------------------- ---------SAKTQFTVGN----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------YEKGIIELYTNLYY------------------------------------TKGRKT KTIKLGSF---------------------------------------------------------------- ------------------------------------------------------------------------ -------------------INGKMYYNHALIKEIG----LQGRI--FPEK--------MKD----------- ----------FDGFR-FKVAAFH------------------------------------------------- ---------------------------------------------------------Y-PP----------- ---------------------------------------KVIQ----------------------------- ---------------E----------------------------------------RSGKWGGVE-T----- ------------EIIRQVGN-S----------------------L----N----------F----------- ------------S----IEVEE-PEDRMK---------WGS------------------------------- ----------------------------EYIKNG--------------TS---Y---------F-------- TG------------------------VMG--KMV----------Y------K--------------Q---ND FGFG-----------------------------------------------------------NHFIT---- -PER---LEV--M-----------DM-T-IP-----YHIDR---ACF------------AV----------- --------------------------------PAA-KEIPNYF-------------TFILP---YH------ ----------------------------------WLV--W-LLI-LSTFLF----FI-L----------PSL VIFLRF------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------DDESPKGIYE------------------------------ ---------------------------------DIYQ-----GFWL---MFF--------YFT--TNINQL- --------PDPVK-PRRGALRLFLSV------SWG-----FVLIITLAYSM-----LV-----TS------- ----------------------------GLS----------------------------------------- -----------WGVRD---------SGGWP---------------DWF----K------------------- -------------D----------------------------------SS-DD--------LSKQV------ -FNGF----------------------------------------------------KNVKTFEE--G---- VSKVA----------E-G-------R-Y-A-FLNSEAALEYLISANYTNQFR-------------------- --EKTIHISRQC-FVP------------------------------------------FR--------IGIC MPLG-K------------------------------------------------------------------ ---YHL--------------------------D--------------------------------------- -------------------------------------------------------------------IL--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_023343878.1/1-188 uncharacterized protein LOC111713276, partial [Eurytemora affinis] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------M------------------------------------------------------------- --------------------PLSSIL---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------FPDL--------FRN----------- ----------MYGNP-IHTVSMD------------------------------------------------- ----------W----------------------------------------------S----------IFIQ -----------------------------------------IR----------------------------- ----------------------------------------------------------KTSAGFE-F----- ------ADSMGERFINIISK-K----------------------I----N----C----SF----------- ------------TASR-------PSD---------GL-WGSFV----------------------------- --------------------------------NG---------------S---F------------------ TG------------------------VVG---EV--------------ER-G--------------Q---AD LTF------------------------------------------------------------DLSIT---- -YQR---NEV--V-----------DF-------PDSIRGDP---LTF------------AISTPL------- -------------------P-----------LPQS---------------L-----SVVRP---FP------ ----------------------------------NPVL-W-IFI-IIA-------CA-A---TG-----VCL YILQRV------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------SSKT-------------------------------HQG- ---------------------------------------------------------------MS------- ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----S------------------------------------------------------------------ ------------------------------------------------------------------------ -------D-------------------------------LA-------------IGTNL--------LLSF- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_023348082.1/1-451 glutamate receptor U1-like [Eurytemora affinis] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------MS--ILNYWKSLSNEK----EKSDFMV-----------------------T KHITVGSV--------------------------------------------------VDVDP--------- ------------------------------------------------------------------------ ---------------------------IHLTEKK------------------NG--MR-------------- ------------------------------------------------------------------------ -----------------I---------------------------------------Y-KF-------GVL- ---------------------------------------KEI------------------------------ ---------------------------------------------------------FDAFSSTY-N----- ------------MSYNIIPT-L-------------------------------------------------- ----------------------------------DDS-YGVDV----------------------------- -------------------------------GNG---------------S---F------------------ SG------------------------VIG---MV--------------QR-K--------------E---VD VGGG-----------------------------------------------------------IFSRM---- -EER---QKV--V-----------DF-SAAI-----GVEA----MNI-------------M-WVN------- --------------------------------VDLADT-DY---------------IIA-P---FT------ ----------------------------------NIV--WLYVL-IAA-------FL-M---GP------IM YIMIN-CFERNVLLDT-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------PPQYIG------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------LMN-----YYWF---LYG--------ALV-----KQG- ---------SSIV-PSTDVMRILFLT------WWI-----YITFLTAEYTA-----QL-----TA-NLTKNN ---RTLPIHHLQDMSSDPSFKWATPGNGSFQ-----TMIDSWPDFVN------------------------- -----------LKND----------IISGKG--------------RYI----G------------------- -------------S----------------------------------AD---------------------- -YK--KEG--------KREG-------------------------------------SSACTYS-------- ----------------------------------------QLNKYTFG-----------------KVSL--- ---------------------------------------------------------------------GLI FPKE-SRQ-------------------------LQEMFNK-----------VLQKLLQSGLIEH-------S TD---V-------------------------------TSPN-------IDLESACKEVVGM----------- --------------------EPKKIF---LYEVSMTFQMML-------------GGGIV-AAI----VFGLE ILCLPLWEEIKLQ-------------------MKGC-KRF-------M-REEK------------------- ------------------------------------------------------------------------ -------------------------------------RRRR------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------RLNKIHV ------------------------------------------------------------------------ ----------------------------------------------------------H------------- -------------------------------------------------LVQHKI----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_025017166.1/1-826 ionotropic receptor 25a-like [Tetranychus urticae] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------MAV-----------------PMITVSSSTCDPESAWV NLNQWEAKHLINF---ISPVTIFLR--------SVIDV---VNH-LQ------IKNGQI------------- -------------------YIEQELAFYLP--------CLIS-EPSL------------------------- ---------------------------VN--FTFRTLEIND-----------------------DTKGIKIQ QLI---------------------QLIGSSV-----------KQKV--------VN---------------- --------FIG-------VGR--SSFVN-------------------------------------------- -----------------------KLI-----------ETF------------RQN---NLFR---------- ----HPF--KLIVL----------------------------------------------SKD--------- ----------------------------------EDKIKCF--------LCKHGQLIAGQPLFL-------- ----PSSDYDEPPLSAHFHPTKL-----PAK----------------------------------------- -----------DVFEFYYY----H----DL------------------IHLLLQ--SVNSI-S--------- ----DQLNATINGTFS-------------------------------------SLSTKQSELSCWT------ -NQS-SSDNLKKLITIPFAES---------------------------LENYGEE----------------- -----NYGKLGPFKLTK---------------------------VHSNDNSITGYQ---------------- ------------------EISIRLKRHTY--------------------------------------YADYF DRESIGEW--------------------------------------------------EAGLP-NGR----- --------------------------------------------I--------------------------- ---------------------------YYTARQS------------------------EDS----------- ----------DASDS-ARVKIAVFL----------------------------------------------- ---------------------------------------------------------T-PP--------YLT ------------------------------------------------------------------------ -----------KRM-N-------------GS--------------------------EIIYEGFL-I----- ------------ELFDEIRH-L----------------------LGD--K----------FP---------- ------------A----YELVE-ITE---------TA-IGLMEINLEE------------------------ ----------------------------EEAEEGNSD-----------IV---F------------------ SG------------------------LIN---EI--------------IQ-G--------------T---YE MALA-----------------------------------------------------------LTEVT---- -EDR---TIG--V-----------DF-S-QPI----FDLIG---FSI-------------L-MKR------- --------------------------------PIR-ES--HEWK-------------FITV---LE------ ----------------------------------WDV--W-LCI-SAA-------YL-F---TS-----ILL SIFDRF------------------------------------------------------------------ --------------------SPYS-FRN-------------------------------------------- -----R------------------------------PEKF-----------------EHES----------- ------------------------------------------------------------------------ ---------------------------------EECKR-IF------------------------------- ---------------------------------TLKE-----SLWF---CFI--------SLT-----PQG- --------GGDA--PKCISGRLVAAI------WWL-----FGFIFVASYTA-----NL-----AA-FLTVSR L--EN-----------------------RVD-----SMDGLSKQY----------------------KIR-- -----------YAPID---------KSAAD---------------GYF----T------------------- -------------KMAYIEDKYYDIWKNLSLDDSIDEDERANLAVWEYPV-SD--------KYTKI------ -KAQIVEA---KK----------------------------------------------PYSLEE--G---- FRRVRESVSA-----S-E-------G-F-A-LISTSLDVEY--------------------FSYLHCD---- -----VYKAEQD-FAF-HP-------------------------------------------------IALP ISKN-S-PN-----------------------NLKELIDPI-----------ILELKENGFIAS-------- ---L---------------RTKYW-------------EN-------------NPERKSCPDWRKL------- ------------------------SNGLILADTWGMFLIIG-------------IGLIC-TLI----VISIE ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------NCIIIAM---RKKKSTVKT----------- ---------------------------------------------------KKELIKKFY------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_027213332.1/1-524 glutamate receptor ionotropic, kainate 3-like [Penaeus vannamei] ------------------------------------------------------------------------ --------------------------------------------------------------MNMDRLSERV G----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------CSI----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------SNRREIF---------------------------------- -----------GN--QSSQIREESRL-------DVSE----------------------------------- --------------------------------------RFVD-THLP------------------------- --------------------AVIRKGWML--GVGSPCA-------------------------WEVDAFLT- -------------------------------TPPPP----FFTLRTKHVRA---DKQYC------------- ------VAFVV-------LAS--LESVA-------------------------------------------- -----------------------EVF-----------AEV------------QQT---SWFL---------- -----GT-AKYILS------------------------------------------YTAEVITKEML----- ----------------------------------------------------------------------A- ---------------------------ADPI------------L---------------------------- ---------RTSYDFVLAT----------------------------------------------------- --------------------------------RLPLE----------------------------------- ------------------------------------------------------------------------ ---------------------------------------------GGSGLPPRVESSLG------------- ------D--------EARTLFALLQNCPYCD-----------------------A-------GDPR------ -VNLVDKW---------------------------------------------------------------- ------------------------------------------------------------------------ --------S----------------PREGFLIGR---D-L------YPDL--------FRD----------- ----------FNGHR-FRAVTLV------------------------------------------------- ---------------------------------------------------------Y-EP----------- ---------------------------------------FSCY-----EK---------------------- ------------------------------------------------------------IDGVI-VPA--- ------DNCVDNNMLREIAN-N----------------------L----N----------F----------- ------------T----YVFVE-PSD---------GQ-WGH------------------------------- -----------------------------RLDNG---------------S---Y------------------ TG------------------------VIG---AV--------------ER-R--------------E---AD FSL------------------------------------------------------------NIAIT---- -QDR---EEK--V-----------DC-T-IG-----YHVEP---ITF-------------A----------- -------------------------------TSKP-RP-LNQAL------------ALIRP---FA------ ----------------------------------PNM--W-AAF-SIT-------LV-V---TG-----PLY FLTCKF------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------TVAPF-----KKV---------- ------------------------------------------------------------------------ --------------------------------------------------------TPP------------- ---------------------------------TLVK-----SYLI---IFA--------ACF-----NQG- --------V-KWL-PV-LSNRVFGIT------YVI-----TMFVTVTVYVA-----ML-----TA-TLTLPT L--SP-----------------------TLN-----TLEELVRSDFS-WGI--------------------- ---------------Q---------DLGAA-------------DYQLL----K------------------- -------------S----------------------------------ST-VP--------LYQKV------ ----------------FKGL-------------------------------------SPCPSLDE--C---- ITLAR----------D-S-------K-Y-A-FITWRTYLE-------------------------------- ------------------------------------------------------------------------ --------------------------------------DRI-----------AVRLVQT------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------PK---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_027219275.1/1-699 glutamate receptor ionotropic, delta-1-like [Penaeus vannamei] ------------------------------------------------------------------------ -------------------------------------------------------------MATTRPFAFAV L----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------FLSSPL-----LGVL----------------ASAA------------- ---------------TAGEAEGLGN--------GFSKES------------------V-------------- -----------------------------V--------SFVA-SRVR------------------------- -------------------------------------------------------RSQE---SLRATSTGLQ DPP--------------------------------------------------------------------- -------------------GI--NKHTS-------------------------------------------- ---------------------IYTNLK---------FRAA-----------SRGH---HLTAC-C------- ---PRQE-ARWKQAV--------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------KQAVEENLSE--------------------------C----------AISIFAD--------- ----HDFGFSL------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------ASL-FPSNPVKVFTLE---------------------------------EE---- VLTSRSTW--------------------------------------------------SRA--LCDAYIFVV GEGDALLRHADVSHYHDHDPHSHDPHPYWNYRAFHLVLLLGEGEGALLPS-EVAGLYNFRKTENLLVLQRGR GGDILAWTHLPFSRGAVRVFLVDTWRRGRFLKGR---D-L------FPEK--------LDN----------- ----------LQGFP-LRVATFE------------------------------------------------- ---------------------------------------------------------H-PP----------- ---------------------------------------SVVY----------------------------- ----------QHDE-D-------------DPR------------------------KVLDRLGVD-M----- ------------QIVQTLAG-A----------------------R----N----------F----------- ------------S----LEFTE--VSH--------DELWGY------------------------------- -----------------------------ELPNG---------------T---W------------------ LG------------------------LVG---QV--------------FY-E--------------K---AD VGAC-----------------------------------------------------------NMFLD---- -LHR--WRQV--------------DY-S-VP-----YNFER---GCF-------------V-APA------- --------------------------------PKP-LV--NWQ-------------APLLP---FS------ ----------------------------------GLT--W-ASI-AVA-------LA-L---CG-----GLL YAVVAL------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------S----------------SQAELP--------- ------------------------------------------------------------------------ ---------------------------------------EF-----------R------------------- ---------------------------------SVVH-----DYLY---MAA--------AFT-----MRA- --------P-HIR-PSQPPVRVYVGF------VWL-----FCLILATAYSA-----NL-----VA-FLSSNQ -M-SA-----------------------PVD-----TLEQLSRSGLR-IG---------------------- -------------------------------------------GHAFW----K------------------- -------------TQFSA------------------------------SI-DP--------LVRDF------ -SNVLE------------------------------------------------------SDVEL--S--SL FDRVE----------G-G-------E-F-A-LIENKQYLELQAGARF---------------TYGS------ --RTTIRIVPEC-LLP-YS-------------------------------------------------IGLA FQKN-S-P-------------------------LKRNFDGV-----------ILRLFESGVLQK-------- ---W---------------KEE-V----------------------------VTFYRRQYSGRKLDDEFAN- ----------------------TRVRPLELTQLQGVFFVLG-------------LGYVA-AAL----ALAGE ----------------------------------------------------AVVSL--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------YTPSP----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_027228211.1/1-286 glutamate receptor ionotropic, delta-2-like isoform X1 [Penaeus vannamei] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------MVL-------MV-A---SM-----AFG ALY--------------------------------------------------------------------- ---------------------DHL-AL--------------------------------------------- -----RWS---------------------------------------------------LP----------- ------------------------------------------------------------------------ ----------------------------------NAMN---------------------------YHEKAEG SR------------------------------TFYFR-----LEW----IVK--------VLL-----LES- --------I-DLL-PTSLTGRVLLGT------WMV-----VSLILSSAYQS-----IL-----TS-LLAVPK V--EV-----------------------PVD-----SLQDLLDY----------------------GKIP-- -----------WSVEH---------GTSIH---------------QLL----D------------------- -------------E----------------------------------ES-SD--------IYKQI------ -NSK--------------VF-------------------------------------YVKSSFDE--K---- -DRMK----------E-K-------R-F-A-ILCDFFSMKMIMSDDYGQ--------------TGECN---- -----YYIAKEV-IWS-AA-------------------------------------------------MAFA FPKG-S-H-------------------------ITAHFNKW-----------VMAMKESGLVNQ-------- ---R---------------LWAAA-------------TN-------------A---TACLVPPEQQAGAET- ------------------------SSVLSVLDLGGVFLVWA-------------GGMVS-SIF----MFLME KL---------------------------------VK-CQ-------R-I---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_027229951.1/1-470 ionotropic receptor 93a-like [Penaeus vannamei] ------------------------------------------------------------------------ ------------------------MEGGSVE--WNGGRERGRSRKPWV-WA--AL-HILALLVTAARAQ--- ------------------------------------------------------------------LDNEDS ------------------------------------------------------------------------ ----------------------VLGVFMD------------------------------------------- -SGIVQGERSVAQ------DLVVSTV-------SASAAAMTR--------------------GSVTVKALSS --MND-TMPE-NMAAVL--TMSSCEATHAWAKGLAEM---GKLHIAIGEG---------------------- ------------------------------------------------------------------LPAGCP R----------------------------IRFPTALTV-----------------PLSS-GA---------- --------------------RDIVQ--------VFTDLR--NKNTLT------WNDIT-------------- --------------------------------------LIHD-DSV-------------------------- -----------------------DKPEIN--DLVNLLADSTDMSK-------------------ETAITIVD LASAE--------------------TSSMKL-----------GKLFSSLG-PRPGEPQN------------- ------RQFLV-------IAY--KDDII-------------------------------------------- -----------------------PIQ-----------DLA------------RSL---GLFG---------- -----SQ-HQWLFV----------------------------------------------VPNTHAL----- ------------------------------------------------------------------------ ----RYDMDSY----------------LANM----------------------------------------- ---------KDGDNMAFVY----NMSDLAPTVNCNNGYD-----------CYIKL-LTSQF-V--------- ----ESLSEALTKELDLYFQVSEE------------------------------------------------ -EWE-EVKPTPAQRAITIVKM---------------------------MMEKL------------------- -----------------------------------------------KESDECS------------------ -----------------RCTRWGLQAAEV-------------------------------------MDSERF ELLNVADW-----------------------------------------------------RPMTG------ --------------------------------------------LSLLDD---------------------- ---------------------------------------L------FPHV--------TGG----------- ----------FRGRT-IPVTSVH------------------------------------------------- ---------------------------------------------------------Y-PP--------WQI -----------------------------------------FE----------------------------- -----------KDK-S-------------GRV--------------------------VGYSGLM-F----- ------------EVLNELAS-K----------------------L----N----------F----------- ------------T----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_027233367.1/1-324 glutamate receptor ionotropic, kainate 3-like [Penaeus vannamei] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------MRTLGA-F----------------------F----N----------F----------- ------------R----PEPRV-ALG---------DV-VGR------------------------------- -----------------------------RDANG---------------R---W------------------ MG------------------------ALE---LL--------------KD-E--------------E---AE FTVL-----------------------------------------------------------PVTVS---- -SPR---EEI--V-----------DF-S-IL-----LGTTT---FGI-------------L-VRR------- --------------------------------PAY-VP--KPD-------------ALLRP---FN------ ----------------------------------VDV--W-LWI-LAM-------MG-I---MG-----PLI YLIILL------------------------------------------------------------------ --------------------RVRL------------------------------------------------ ---------------------------------------C-----------------RGDP----------- ------------------------------------------------------------------------ ----------------------------------TLTR-TF------------------------------- ---------------------------------PLDQ-----CVWF---VFG--------AMM-----KQG- --------S-VLS-PISDSSRILFAT------WWL-----FITIVTSFYTA-----NL-----TA-YLTFNS L--VL-----------------------PIE-----KAEDLAK-Y---------------------PDIK-- -----------WVAFR---------DGALA---------------DII----M------------------- -------------------------------------------------V---------------------- -------G---MG----------------------------------------------------------- ------------------------------------------------------------------------ --------------YG-GIIMVG---------------------------------------------VGYG ------------------------------------------------------GIIMVGVGMG-------- ---Y---------------HHGGC-------------GS-------------G---GIIMVGVGS------- -----------------------GG---------IIMVGVG-------------MGIIM-VGM----GLGCH H----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------G---------------- -------------------------------------------------------GCGV-------WGI--- -----IMVGVGL------------------------------------------------------------ -----------------------------------------------------GYHHGGCG----------- ------------------------------------------V---W-----GITMVDMG------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------YVVL-------------------------------- >XP_027233443.1/1-227 glutamate receptor ionotropic, NMDA 2B-like [Penaeus vannamei] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------MRWI---------------TYLKGEPEV----------------WTLRVPP--- --IYCPRDGLYCSPNVC--RLRACNSC--------------------------------------------- ------------------------------------------------------------------------ ------------------------SQSY-------------------------------------------- ---ASMSGLRIQM---APSIHHQAA--------AMLSI---LVR-YQ------WHAF--------------- -----------------------------T--------IVTS-HIAG------------------------- ------------------------HADFV--QTVRDQVHQYEDPHDI--------------SKPKIKFTIID TVL------------------------VNRA-----------EDDLGVIADSEARI---------------- --------MLL-------YST--RMEAA-------------------------------------------- -----------------------SIM-----------RAA------------ERL---GLTG---------- ----KNY--VWIVT----------------------------------------------QSVV-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------GP--------DIH -----------------------------------------AP-----SAFPV------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------GMLD----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------LNPQ----------SYREP----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------RMV-----------------P-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------VHSSEP--------------------------------------------------------- -------------------------------------TEDNNLSHN-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------NTT-----------LL------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_027236447.1/1-295 glutamate receptor ionotropic, delta-2-like [Penaeus vannamei] ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------MYNR----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------DQEQ--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------FN -----------------------------------------TQ----------------------------- ---------------S-------------------------------------ITQLKISI-----S----- ------------EYFQ-------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------TD-ED---------------K---W------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------L-------------I-IVF------- --------------------------------SEC-------------------------Q---LH------ ----------------------------------PK------KC---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------D-----GHY------------------------GG- --------G-DLQ-VTGLSVRLCLLS------VVL-----TAWLIIVFYTS-----VL-----MS-SLAVPL L--SP-----------------------PFK-----DMHGLLMAGT--HN---------------------- -----------LGLQE---------GNSEV---------------ERM----R------------------- -------------T----------------------------------SQ-DP--------VLQKV------ -WSDIVLQ---DP------T-------------------------------------NLVPSANE--G---- IRRIL----------K-E-------R-F-A-FLMDLEYFAYHRGSD--------------------CR---- -----LFPLPDH-IFT-YG-------------------------------------------------AGMA VRKG-S-P-------------------------LRLVFNDQ-----------VLQQQVTGITDR-------- ---N---------------RKRHL-------------PSPPL----------------CAPDGPE------- --------------------------ALGLGTLLTSFLLLA-------------AASVV-ALL----VLFLE VV---------------------------------YS-RH-------F-KR-TDS----------------- ------------------------------------------------------------------------ -----------------------------------AGDNR-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------ELILYPLIV---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_027239554.1/1-706 glutamate receptor ionotropic, delta-2-like [Penaeus vannamei] ------------------------------------------------------------------------ ------------------------------------------------------MFIAWNYVFLAIYVSVLV ----------------------------------------------------------------------P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----GGQATNAMDL----PLSEGNG-------PGHQKV--------------------------------- ----------------------------------------TRYKEEVTAAVTQN------------------ --------------------------------------------------------------------TSLS AMRSGVRG-----------------------MVDRVYV-----------------GEWRIARRAG------- ----------------------LVE--------FLIAS---STGR----------QLY-------------- --------------------------------------LLYD-QHS-------------------------- --------------------ESIAS-SMR--AS----HRRGGD------------------------MAVLK Y--------------------------QGSI-----------APLEKELK-SFFHRENL------------- ------RNVIV-------MCS--APNTV-------------------------------------------- -----------------------DVF-----------RQV------------FKR---KMES---------- -----PT-IYWW-L----------------------------------------------ILEDDVT----- ------------------------------------------------------------------------ ----QEVLDN--------------------M----------------------------------------- ---------REGTQISVAL----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------KMDE--------------------- -------------------AKYKLMRSFV-------------------------------------NKDDQL KLQTVGSW---------------------------------------------------------------- ---------------------------------------------WWTPS-EGSQ----------------- ----------------------------HFLKEP-----I------YKDL-MDV----YSD----------- ----------FGGRL-MKSSVVD------------------------------------------------- ---------NW-------------------------------------------------P--------FFR -----------------------------------------VM-----K----------------------- -----------DKA-S-------------G--------------------------EIVSDAGID-F----- ------------HLLNTIAA-K----------------------L----N----------F----------- ------------T----YRLLL-AKD---------GQ-WGG------------------------------- -----------------------------VLPDG---------------S---I------------------ TG------------------------MIG---MV--------------AR-H--------------E---VH FAIN-----------------------------------------------------------EITIT---- -GPR---EVV--V-----------DF-T-LP-----YFLES---TTI-------------V-SPA------- --------------------------------PAE-KN--RAF-------------AVFSP---FT------ ----------------------------------AEV--W-GLL-SLA-------TL-L---VG-----PIL WLI--------------------------------------------------------------------- ---------------------SVA-KEE-------------------------------------------- ---------------------------------------L-----------------V-LK----------- ------------------------------------------------------------------------ ----------------------------------GI------------------------------------ -----------------------------WRADSLSN-----YSFN---MYR--------SMV-----VQG- --------N-KAE-MEQWSHRFVLFT------WFF-----FCFVVYALYAG-----TL-----TA-VLAVPT F--EK-----------------------PID-----SLWDLLGAIEN------------------DGYKA-- -----------TVVYQ---------TSNEFFQGNRPF-----KTTMLL----Q------------------- -------------E----------------------------------AT-SG--------IYKQI------ -WDVF-----------DPSV-------------------------------------GYVYTWDE--G---- VEKVL----------T-G-------K-F-A-YMNAQLGAEIRA----IK--------------RGIHN---- -----YHFAKNT-FYP-QG-------------------------------------------------YAMA LPSG-S-P-------------------------YKGKLEKL-----------LVQLASAGLVDK-------- ---W---------------TRDEV-------------AK-------------V---AGAGGGEAS------- ----------------------KGPGAITLVHLQAAFFLLA-------------IGYST-AGG----VLLVE RL---------------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------AMFFCGRKEFHSSFA------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------GKPI-LVKEIGY-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >evg1564513_PargIR68a/1-600 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------MVDVAR--------RLLKEEL-------------------------------- ------------------------AGCSLT--------VIGG-GREA------------------------- --------------------------------------------------------------AEDFTHLAVN MG------------------------VLYQVS----------SGQLSLENPPNITWWGG------------- ----VCDAFFV------MVEQ--EGTSG-------------------------------------------- -----------------------SVR-----------EYM-------------------------------- ----EDRGAPWHYSGKYV------------------------------------FFSAGGRNNLKLL----- ------------------------------------------------------------------------ -------------------------ATSHVL----------------------------------------- ---------RKTVDVLFVWPG--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------EMGDQAEIWTHWIYSHQ--------------------------------------- ------TL---------------------------------------------------------RFL---- --------------------------------------------AFAS-P---------------------- ---------------------------LGFVKYG---E-L------FPRK--------LAD----------- ----------LRGFP-LVVKTFL------------------------------------------------- ----------F------------------------------------------------APS------VFGE -----------------------------------------L------------------------------ ------------DE-D-------------GRT-------------------------IRPTGGQD-V----- ------------SFILLLAR-Y----------------------L----N----------F----------- ------------T----VQWQH-PGP----LL------WGE------------------------------- -----------------------------LLDNG---------------T---Y------------------ TG------------------------LVG---QV--------------SE-G--------------E---GD LGVA-----------------------------------------------------------NIFLD---- -LQR---SWH--I-----------TF-T-YP-----YTYEL---ACF-------------I-TPA------- --------------------------------PRE-LP---------------RWMALGFP---FT------ ----------------------------------LVV--W-LAL-ATT-------LA-A---VG-----LLY PVLARL------------------------------------------------------------------ --------------------LPSS------------------------------------------------ ---------------------------------------------------------PDHP----------- ------------------------------------------------------------------------ ---------------------------------------EFH------------------------------ ---------------------------------SWGL-----SFVF---TLG--------A-F-----TCR- --------S-MRL-PATDRLRVASLT------LLF-----MGFVIAITFSG-----NL-----TA-FMTTRS V--EA-----------------------AIR-----TLSELARSHLT-IVGFG------------------- ---------------------------------------------NYW----P------------------- -------------IAFAG------------------------------SE-NP--------SVRSL------ ------------------TD-------------------------------------KYKSVY-D--TLPYF RKAAE----------E-R-------Q-V-A-LIENRNHLEFIQRRRYTTR-------------RGESP---- -----LRIQEEC-LAT------------------------------------------YG--------VGAV LSMH-S-P-------------------------LAPYVDKA-----------IHHMQAGGLTDK-------- ---F---------------FREVL-------------TQ------DL---------DDSHHQQEDGE-ASWL DL-------------HDQILIPSGPQVLTVEHVQGAFIVLA-------------VGYLA-ASL----SLVGE VM---------------------------------MV----------------------------------- ------------------------------------------------------------------------ ---------------------------------ADLGLTA-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >evg1827088_PargIR1091_IR75/1-612 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------ALLTPP--------VV---------------------------- ---------PVEA----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------SAQP-------------------- ----------------------RLVPVYA---------W---------------------------TPPPPE FAITTNSW--------------------------------------------------Y------------- ------------------------------------------------------------------------ ------------------------------TGRL---R-A------LSTH-E------QYQ----------- ----------LHGSH-LFVATLR------------------------------------------------- ---------------------------------------------------------G-EP--------FIK -----------------------------------------PL----------------------------- ---------------NTTSNDSNRAVGERGQTSS----------PPPPLPAHITCQQPRAFTGFL-V----- ------------DMLDVLKS-Y----------------------M----N----------F----------- ------------T----YTLYE-VCD---------NS-YGS------------------------------- -----------------------------LK-DG---------------R---W------------------ TG------------------------VVG---EV--------------MY-A--------------H---AH IGLA-----------------------------------------------------------NLGAN---- -YAR---SHA--V-----------SFPK-VS-----TIYGG---AGI-------------I-MKR------- --------------------------------PRT-TI-KDLLA------------VYFYP---FS------ ----------------------------------VNV--W-VCM-MVS-------IP-V---AA-----IAM YCATRP------------------------------------------------------------------ --------------------RRRL-RQL-LNRCPA---VLWPRRHTPTVRTTTRGRTPIRITITRPSAGSTS SQEPRRKLP------SSKSP-----------LSSTPTQRH-----------------QQEN---SPG----- ----------------------------YG------------------------------------------ -----------G-EDKAPDGNNEA--GVLNLNTKEKED-VAQ------------------------------ ---------------------------------SFFS-----GVWF---AST--------VLM-----QQG- --------Q-EVV-PETGPARLVFGT------MWV-----AAVVLYAAYTS-----NL-----VS-YFTVTK M--SL-----------------------PFT-----DLEGLVKSD---YK---------------------- -----------FGTRQ---------GSVYL---------------DNM----M------------------- -------------T----------------------------------SN-TD--------VFKAA-GSKLE SFGESVQ----------------------------------------------------MPSYED--A---- IKRTL----------Q-G-------S-Y-A-FIGDYVVLDYYQKKD--------------------CD---- -----LVLLKQQ-LFE-TM-------------------------------------------------SSFV LPRH-S-P-------------------------ILPAVNYY-----------MSRMNEGGILEK-------- ---L---------------RQRWW-------------SA------HP-----------CPDAATVTA----- ------------------------YQSIGLSEVCSAVLIMA-------------VGIVL-AVL----VSCIE HL---------------------------------RL-RL-------L-RDARHD----------------- ------------------------------------------------------------------------ -----------------------------------DTKDRTTPSSYSYDN---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------AKKTTPLQI-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AgamNMDAR3/1-998 AGAP005527-PA ------------------------------------------------------MFALP------------- -------------------------------------------------WKRSSTLLVVELLLSLLALAGLT V----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------PSSASSSEETLDADATVE------------FAGGPVAAEMLKAHPAGGAF- --------------TVDDGSQPVFPERPDAVYFAVAVTGG----------AKLWGRTLARTLIDMGPPFGHP QGPPLRPIYINLPDSGRFSSKLMTTACDSIDGMPLSGMVIVG-DSPAAKSLALAGN---------------- -------------------AMKVPVLWAK--GGIATLHNSYDEVHWH--------SYHILCDVDTY--VLIS GKKGAPLR-------------------QKPL-----------NPIIVTLP----------TNF--------- -DLIYKKLAFI------------SRSTK-GVVL--------------------------------------- ----------VLCNL-----KVARLI----------MAEA------------QRM---KMLNG-H------- --------FVWLWMDT--------------------------------------------TSATEFY----- ------------------------------------------------------------------------ ----DSGQPSY-------------------------------DP---------------------------- ---------KQQQPLDYPTAE-----------------------GS-------------------------- ------------------------------------------------------------------------ --------------------EM-------------------------------------------------- --------------------------------------------KLKRSSEYLKPHNSS------------- ------GHVLYHHNQDFPVGLLALRPIKMKIDRHFIR---------------------------------AA VRLFAATWAKV----------------------------------------------ERDDTPAAGGG---- ------------------------------------------------------------------------ -------------------------KGRGGPSGR---D-------------------GLAG----------- ----------KAKTM-FRVVVSV------------------------------------------------- ---------------------------------------------------------A-PP--------FVM ESSVN-------------------------------EEGQCLRGLICYQIYTTG------------------ ----RHNLTLMFNEIERRN--RLREIQPASSLHLQEEPRQ-----------KYPLYRTRCCYGLS-M----- ------------DLLQKLAT-E----------------------I----N----------F----------- ------------D----FHLYI-VHD---------GL-FGR------RVPPPPEPTEPPTNVRKPAVATHVE SQSKFDAQSGRSLKRGSKLKLSQAGINATARDEGPQYPFEVPAAPPV-RTRQLW------------------ NG------------------------VIG---DL--------------IS-G--------------T---AD LSFA-----------------------------------------------------------PLSVS---- -KAR---SEV--I-----------DF-T-IP-----YFHGG---VSL-------------LAAPE------- ---------------------------AATDIPLL---------------------AFLLP---FS------ ----------------------------------PEL--W-IAI-FTS-------LN-V---TA-----VAV AIYEWL------------------------------------------------------------------ --------------------SPFG------------------------------------------------ ----LNPW------------------------------------G--------------------------- ------------------------------------------------------------------------ ---------------------------------RQRSK-NF------------------------------- ---------------------------------SMSS-----ALWV---MWG--------LLCGHLV----- ----------AFKAPKSWPNKFLINV------WGG-----FSVIFIASYTA-----NI-----AA-LIAGLL -----------------------------FHNEAKYYEMSMLTQR--------------------VGSPI-- -------------------------ATAAE---------------SYV----Q------------------- -------------Q-----------------------------------------------NDKRL------ -WEHMKKY--------------------------------------------------QLQSIDE--G---- IERLK----------N-R-------T-IDL-LMCDTPILDYYR------------------GTDQSCS---- -----LQRIGDN-YIE-DS-------------------------------------------------YAIG MSKG-F-P-------------------------LKKTMSAL-----------ISKYSHDGYLDILTAK---- ---W---YGDLPCFK----LDREM------------------------------------------------ ----------------------AQPKPLGVTAVAGVFLLLG-------------VGMVL-GVL----ILIIE HV---------------------------------FY-KYTLPI--LR-HQPKDT----------------- -------------IW--------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------KSRNIMFFSQKL------YR ---FINCVELVSPHHAAKELVHTI------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------RQGQITSLFQKSVKR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >NvecNMDAR3/1-382 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------AKSI---------------------------------------------CISGQM-I----- ------------ELLELIRE-Y----------------------V----H----------F----------- ------------T----YEFYL-IRD---------HK-YGSVD----------------------------- -----------------------------------------PVTG----L---W------------------ NG------------------------MVG---DI--------------IT-G--------------E---AD MALA-----------------------------------------------------------TLTIT---- -ASR---SRV--I-----------DF-S-SP-----YGEVG---IGI-------------L-ART------- --------------------------------DTT-LG--SVVNM-----------DFMIP---LS------ ----------------------------------SQL--W-TVI-LAT-------IL-F---VI-----IVL WVLDRK------------------------------------------------------------------ --------------------S-WEWYLK-------------------------------------------- -----G------------------------------RSHF-----------------IPDY----------- ------------------------------------------------------------------------ ----------------------------------KRR---V------------------------------- ---------------------------------SLLE-----SMTY---SWS--------TFV-----HVQ- --------AGTGL-PMSTSARLVALF------FAL-----AMLIVNTSYTA-----EL-----AA-FKVKEQ F--VP-----------------------PIS-----GIEDPKMQNP-------------------PPDFK-- -----------FATLR---------DSSTE---------------AYF----R------------------- -------------FSKDE-------------------------------------------KLRRI------ -YEHMKDN---N-----------------------------------------------VEMVED--G---- VAKLIS-----------G-------E-FKL-YIDDQPYLEHLV------------------SSSGNCM---- -----LRMIGRP-FGI-SG-------------------------------------------------YGIA LAKN-S-P-------------------------WTRPISNA-----------IIKLNDMKALEN-------- ---L---------------WSKWL-------------KR-------------K-----CVTQDEFGKS---- ------------------------PSGLSIENVNGLFVVVC-------------AGFA-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >NvecNMDAR4/1-336 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------Q---W------------------ NG------------------------LIG---EL--------------LR-G--------------E---AD VAIA-----------------------------------------------------------DLTIT---- -DAR---SRV--V-----------DF-T-HP-----FLHVG---MAI-------------LVAVY------- --------------------------------KNR-SG--WLVR-------------FLEP---FS------ ----------------------------------TEL--W-IVA-VAA-------VN-I---VF-----VIL WIIDKR------------------------------------------------------------------ --------------------SPYGHYRR-------------------------------------------- -----G------------------------------SS----------------------Y----------- ------------------------------------------------------------------------ ----------------------------------KERK-KF------------------------------- ---------------------------------HMIA-----SLWF---TWG--------TIF-----HID- --------EVEAR-PMSNSSRTVTLV------FAF-----GMLTLTNTYTA-----SL-----AA-VLVTEA E--VS-----------------------PVSS---AGLRDPRLQNP-------------------QPGFK-- -----------MATVR---------DTSME---------------KVF----K------------------- -------------GSTDP-------------------------------------------TFARI------ -WRQMKPH---A-----------------------------------------------VNSFSD--G---- VQKVIN-----------G-------E-LSA-FIGDEPTLMYAM------------------AHNRKCN---- -----LRLAGKS-FFH-SG-------------------------------------------------FGIA TRKN-S-S-------------------------LTKKFSDV-----------LILYEQFDTSRK-------- ---M---------------ALRWL-------------TG-------------S-----CSQKSE-TTA---- ------------------------FTRMSIKDLGGAYVITS-------------IGL--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_11425601/1-1127 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------MINFDGVS------------------VAEQTT-- --LYDVTTVLHGSPITA--SLQLCQMLI--------SQAVYTVVVA-------------------------- --------------------------------------------------------------------SPPG -GSV--------------------TTAAVSYTCGFYHI-----------------PVICTHSR--------- DSSFSNKNIHVSLLRTVPPYNHQAD--------VWVTL---LKH-LQ------YQQV--------------- -----------------------------I--------LLHS-SDTD------------------------- --------------------GRALYRRFQ--SLAQHRDDDM-----------------------GIKLV--S VIE--------------------FTTGEDSF-----------VVELAAIREELVKV---------------- --------ILL-------YAN--ERDAD-------------------------------------------- -----------------------RIF-----------HDA------------AYL---NMME---------- ----DGY--VWLVT----------------------------------------------EQALHS------ ------QHVPV------GALGLQL------------------------------------------------ ----------------------------KYA----------------------------------------- -----------DDYDAHIT----D--------------------------------SLRVV-A--------- ----LALR--QLHEQE--------------------------------------VVIPDPPITCE------- ------AEGGWDETGIRLFRL---------------------------IQQQVLT----------------- ------DGKTGKVAFDGHGD---------------------------------------------------- ------------------RTHAEYSVVNVQD--------------------------------HHQEHFGQR NLQHVGEL--------------------------------------------------FYDKV-RGQ----- --------------------------------------------MVLEVN-RSSIVWPG------------- ----------------------------GSSTAP------------------------PGY----------- ----------SLPTH-LNVMTLL------------------------------------------------- ---------------------------------------------------------E-TP--------FV- ------------------------------------------------------------------------ ---------YAAAI-D-------------ADEECEGKGK----ELCPLLNPTTREWERMCCWGYC-L----- ------------DLLFTLSD-K----------------------N----G----------F----------- ------------T----FNLTL-SAD---------GN-YGQLE----------------------------- -----------------------------ENQEG---------QK----T---W------------------ NG------------------------MIG---QL--------------VN-E--------------SE-ALD MIMA-----------------------------------------------------------PLTIN---- -PER---SQA--L-----------HF-T-KP-----FKYHG---ITI-------------L-IKR------- --------------------------------TLV-VP--ALVS-------------ILQP---FR------ ----------------------------------GTL--W-LLL-LVT-------VH-I---IA-----FFI WLLDRL------------------------------------------------------------------ --------------------SPV--YKL-------------------------------------------- -----------------------------------------------------------DG----------- ------------------------------------------------------------------------ ----------------------------------KDTD-SL------------------------------- ---------------------------------VLSE-----SFWF---SWS--------VIL-----NSG- --------LTDGT-PRCVSGRVLGIV------WGG-----FAMIIVASYTA-----NL-----AA-FLVLDT P--IS-----------------------AIT-----GINDARLRNP-------------------VENFT-- -----------FATVR---------GSSVD---------------MFF----R------------------- -------------RKTE---------------------------------------------WANM------ -YRVMEAH---N-----------------------------------------------YPTVDQ--A---- IHAVRN-----------G-------S-LQA-FIWESSRLEY--------------------EASRDCE---- -----LVTVGEL-FGR-SG-------------------------------------------------YGIG LQKG-S-P-------------------------WADKITLD-----------ILDLHERGYMEV-------- ---L---------------DKEWI-------------WT-------------EGSE--CSEDDHHSLD---- -----------------------FSKRLGLKNLEGIFIMVA-------------GGILS-GTF----LILVE II---------------------------------Y---------------------------DR------- --------------WRNPTQGRGG---GGSDDSHLQQQDDGDGGGSGGDGGGGGVSSMDEVGGLLKVGDQRT ATTQAEVYPSEEECCHAGAL-----DSPDN---SGKNLSANVCSYTTHRA--------------------EH EQSPPRRCS--------------------------------------------------------------- -----------------------------------------------------VCSTDEETQSL-RLLD--- -----S----CSPEGQAVMQDVEDRLRASPNIPEEWKSRTSLQWFHYYLDILRKDAAADDESRTPETLAVME DFVDFMRDSGIRDDYVHSQAMALCEDKCDNHDNVKPHGRQGRGEGPDSM---Q-GGFTEGMDSISV------ ------------------------------------------------HDPQMTPLPRMFMKTLNEKLPDVI DNCSEIGR--------CIL-------------EDDDDYESYITGIN-------------------------- ---------------------REDGETGRTTHEERQTLMGPDDSSDRS------------------------ -------SIYI------------------------------------------------------------- >Hame_1703709/1-647 ------------------------------------------------------------------------ --------------------------------------------------------------VGVGVAVGVT Q----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------SIYASGTLASL--------------------AGVPLIARSVKGY------- ---------------VDETLKNLLPD------LVVANPRL----------SDLWEAATS------------- -----------------FISAL--EWCQPI--------LIHD-DSPQALQLA-------------------- ---------------------------------------------------------HIASRDDTYEPVGLS LSASLPRH-----------------HFQNRL-----------SGILHTV----------------------- -----RRLIFV------------SGTVN-FV----------------------------------------- -----------------------KVV----------FSHG------------EDL---DMFNG-E------- --------YIWILLDV--------------------------------------------PLPGNLS----- ------------------------------------------------------------------------ ----ESLRPGLLSLR------------PDFL--R--------TP---------------------------- ---------KKQLLINFVKSS-----------------------VS----------VISEFFK--------- ---ETTVASSA-------------------------------------------LLATSAPVLCQ------- -----VPYRNLSTSQFELHRQL-------------------------------------------------- --------------------------------------------KEKLASSRLSQRSLP------------- ------GLTPFFYVEN-------LVPKKIGVGAQWTR-VG--------------------------YVNGSQ VQINAIFWP--------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------GR----GY---K-------------------GVSE----------- ----------QNKRM--RVALAE------------------------------------------------- ---------------------------------------------------------A-PP--------FVM TSHLI-------------------------------ENATCLTGVICLRVFS-------------------- -----EEVAATFADME-------REVVNASR-----------------------GYEVVCCSGLA-V----- ------------DLMINVAT-D----------------------L----E----------I----------- ------------E----LQVYL-VMD---------GT-FG-------------------------------- ----------------------------APRSTG-------------------W------------------ TG------------------------IVG---DL--------------LD-G--------------S---AD LSFA-----------------------------------------------------------PLSVT---- -AQR---ARH--L-----------DF-S-DP-----YFFSS---MSM-------------LSSTK------- ----------------------------QMEVPLL---------------------AFLIP---FS------ ----------------------------------PDL--W-IAI-FVS-------LN-I---TA-----FSV AVYEWL------------------------------------------------------------------ --------------------SPFG------------------------------------------------ ----LNPW------------------------------------G--------------------------- ------------------------------------------------------------------------ ---------------------------------RQRSK-NF------------------------------- ---------------------------------SYGS-----ALWV---IWG--------LLFSHLV----- ----------AFKAPKSWPNKVLINV------WGA-----FSVIFVASYTA-----NI-----AA-LFAGLF Q--TR-----------------------DLHNR------KLMSQR--------------------IGALR-- -------------------------ASSVE---------------YYV----S------------------- -------------K-----------------------------------------------INPEL------ -WAYMRPH--------------------------------------------------LFDNYTH--G---- LNNLH----------T-G-------R-LDL-MVGDSAVLDYLR------------------ANDPGCT---- -----L------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_1748844/1-643 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------MCCSGFC-I----- ------------DLLEKFAS-D----------------------L----G----------F----------- ------------S----YELTR-VED---------GK-WGTVDQ---------------------------- --------------------------------DH---------------R---W------------------ NG------------------------LIG---EL--------------LK-R--------------EGEGAE MALT-----------------------------------------------------------SLKVN---- -KER---ESV--V-----------DF-T-VP-----FLESG---IAI-------------VVAKR------- -------------------------------------T--GIISPT----------AFLEP---FD------ ----------------------------------TAS--W-MLVAFVA-------IQ-V---AA-----LTI FLFEWL------------------------------------------------------------------ --------------------SPGG-YNM-------------------------------------------- -----R--------------------------------MA-----------------P-------------- ------------------------------------------------------------------------ ----------------------------------PRDH-KF------------------------------- ---------------------------------SLFR-----TYWL---VWA--------VLF------QA- --------AVHVDCPRGFTARFMANM------WAM-----FAVVFLAIYTA-----NL-----AA-FMITRE E--FH-----------------------DFS-----GINDTKLQYPT-T---------------VNPACK-- -----------FGTVE---------ETNSA---------------MVL----K------------------- -------------RHHSL--------------------------MYNYMV-RH--------HYN-------- -----------------------------------------------------------RPSVQD--G---- VKSIKK-----------N-------E-LDA-FIYDATVLDYLV------------------GQDDDCQ---- -----ILTVGSW-YSM-TG-------------------------------------------------YGLA FPRG-S-K-------------------------YLNLFNNK-----------LMSYKDNGDIER-------- ---L---------------QRFWM-------------TG-------------T-----CKPMKQQRRA---- ------------------------SEPLAIEQFLSAYLLLG-------------IGMVL-AMV----LLGLE HV---------------------------------YF-KY-------V-RKHLAKKD--------------- ---------------------------------------------SGG------------------------ -------------CC--------------------ALVSLSMGKSLTFRG---------------------- ------------------------------------------------------------------------ ---------------------------------------------------------AVYEATD-KLRR--- -----H--RCRDPLCDTHI------------------------W---------------------------- ----------------------------------------KVKHELDMA---RMRIKHLEKE-LEA------ ------------------------------------------------NGVKPSLKKQQLQAGSGVSAGPLL ACCWTSSSDDSTWVRTVSLDVTSSQQQQQQQQQQQQQQQQVTHHLQHHHHHQQQQQQQQSHHHHQHQQQQSH HHHHHHHEQQQHQSTTQQVYRRHDLTRNHIITTEAGLPDMPVLPSASS-----------SGGAASAPHQRKR SYEYRPISTEVA----------------------EIETVL-------------------------------- >Csap11004876_IR68a/1-637 ------------------------------------------------------------------------ ------------------------------------------------------------VVVV-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------AARRHLL-----------------PATPSTGL--------- ----------------SGSLAVVAR--------ALLQEEL-------------------------------- ------------------------RGCFLT--------LIGG-GHEA------------------------- --------------------------------------------------------------TQLLAQLAAS LH------------------------VPLQVS----------QHELSSGRPPNITWVQS------------- ----SCDAFLV------TVED-----VG-------------------------------------------- -----------------------KAL-----------EYL-------------------------------- ----EGEELPWNYRGKYV------------------------------------FFGASCVSDLLPL----- ------------------------------------------------------------------------ -------------------------VTSDKM----------------------------------------- ---------TKTEHALFVCGG--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------RAAG-LEVRTHWLYSLR--------------------------------------- ------TW---------------------------------------------------------SLI---- --------------------------------------------GHAT-L---------------------- ---------------------------RSLNRES---P-F------FPPK--------LAD----------- ----------LQGYP-LVVKGFP------------------------------------------------- ----------F------------------------------------------------HPS------VFGK -----------------------------------------VA-----EEPPE------------------- -----------GGD-E-------------GGNTKE----------------TEVRPKMYPEGGQD-V----- ------------SFVRLLAK-H----------------------L----N----------F----------- ------------T----DVWRH-PGP----TL------WGA------------------------------- -----------------------------LREDG---------------T---Y------------------ SG------------------------VVG---QV--------------GA-G--------------E---GD IGVG-----------------------------------------------------------NLFLD---- -IMR---TRF--A-----------TF-S-YP-----YTYEF---ACF-------------L-TPA------- --------------------------------PRE-LP---------------PWISLGSP---FR------ ----------------------------------REV--W-AAL-IFT-------FL-G---AG-----FLS LFIARG------------------------------------------------------------------ --------------------VDFP------------------------------------------------ ---------------------------------------------------------KDLP----------- ------------------------------------------------------------------------ ---------------------------------------MFY------------------------------ ---------------------------------SPSR-----WLIY---TVG--------T-V-----TCQ- --------S-HEV-PQTNRLRVASSA------LHF-----MGFVVAISFSG-----NL-----TA-FLTTPN V--EP-----------------------ALK-----SLRQLDESGLT-IVGFS------------------- ---------------------------------------------DYW----V------------------- -------------RFFLA------------------------------SQ-NT--------HIVSF------ ------------------AS-------------------------------------KFRDVP-N--TLPFF RVAAE----------E-R-------T-V-A-VLENRNHLQYILTQFYTTR-------------RGETP---- -----LRIQEEC-LVT------------------------------------------FG--------VSAA LTKH-S-P-------------------------LAPYINEA-----------IHYMQAGGLTDR-------- ---F---------------FEEVL-------------LQ------DL---------D---HDDHSEE-ETWL DL-------------HDKDIVVTGTKVLSLEHLLGAFVLIA-------------SGLLV-ASL----TQAVE ------------------------------------R----------------------------------- ------------------------------------------------------------------------ ---------------------------------CSLSLASTSLTHRHHS----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame11304108_IR68a/1-640 ------------------------------------------------------MCLM-------------- -----------------------------------------------------TWWAWKGVLVMM------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------CWVW----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------QGVGARQMA-----------------PATGLQHL--------- ----------------SPIMMDVAR--------SLLEEEL-------------------------------- ------------------------SGCSLT--------TIGG-GHEA------------------------- --------------------------------------------------------------AESFSQLAVD LN------------------------VSYQVN----------PGELDPVSPPNITWWQT------------- 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----------LEGHP-LMVKTFP------------------------------------------------- ----------F------------------------------------------------PPS------VFVE ------------------------------------------------------------------------ ------------GE-E-------------GGS-------------------------LHPLGGQD-V----- ------------SFIILLAR-Y----------------------L----N----------F----------- ------------T----VQWRH-PGP----SL------WGR------------------------------- -----------------------------LYDNG---------------T---Y------------------ TG------------------------IVG---QV--------------GV-G--------------D---GD IGVG-----------------------------------------------------------NIFLD---- -IRR---IYF--A-----------KF-T-YP-----YTYEH---ACF-------------I-TPV------- --------------------------------PRE-LP---------------RWMALGSP---FS------ ----------------------------------LVV--W-STL-AAT-------LG-V---VT-----LIY PAIARS------------------------------------------------------------------ --------------------LVHL------------------------------------------------ ---------------------------------------------------------PDHP----------- ------------------------------------------------------------------------ ---------------------------------------QFY------------------------------ ---------------------------------SWGR-----ALVY---TVG--------M-L-----TCQ- --------S-QRG-PATTRLRVPTIL------MLL-----MGFVVGVSFSG-----NL-----TA-FMTTRS V--EP-----------------------AIR-----TLAELDKSGLT-VVGYQ------------------- ---------------------------------------------DYW----T------------------- -------------TVFND------------------------------SD-NP--------NVRAL------ ------------------TT-------------------------------------KYKAVE-D--TNPYF REISE----------K-R-------D-M-V-LIENRNHLEFLQKRFYTTR-------------RGESP---- -----LRIQEEC-LAT------------------------------------------FG--------VSAV LNMQ-S-P-------------------------LTPYVDKA-----------IHYMQAGGLTDK-------- ---M---------------FKEVL-------------TQ------GL-----QSTVDDGLHDDEDDDRPSWL SL-------------HDQDRIASGPQVLTVEHMQGAFIVLG-------------VGYLA-AVL----SLVTE ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------LASRCCAS--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla_11407343_IR93a/1-877 ------------------------------------------------------MAPS----------IPVS KV----------------------REGADGG--VTMQGQRAGRSRVWV-WR--CLAAV--TILVSTHAQ--- ------------------------------------------------------------------LDYEDS ------------------------------------------------------------------------ ----------------------TLGVYLE------------------------------------------- -SGMLQGLRFQTQ------ELVKAAV-------KEGSAAMTL--------------------GSLSVEFLAS --MND-TLPN-NTTAVL--TMVSCTNTHAWADRLVQN---GTLHIALTE----------------------- --------------------------------------------------------------------SGCP R----------------------------ITTSTAITV-----------------PLIK-GS---------- --------------------RDIVQ--------VFRDLR--DKDTLI------WRDIV-------------- --------------------------------------LIHD-NSI-------------------------- -----------------------DQLELN--DIVTLLMETAPGTPITP-------ENQKTSGTQESSITIID MATPE--------------------ASSMKL-----------GKLFSSLR-PRAGEPRE------------- 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--------------------SPYY-T---------------------------------------------- ---------------------------------------Y-----------------YGLY----------- ------------------------------------------------------------------------ ----------------------------------NGRG-LF------------------------------- ---------------------------------QLHN-----CFWY---VYS--------AVL-----QQG- --------C-DWD-PMSDSGRLVVGT------WWI-----FVLLVVTLYSG-----NL-----VA-YLTFPK V--EN-----------------------PVN-----TLDDLLSLR---------------------ATVT-- -----------WGYFR---------GTVLE---------------NYF----Q------------------- -------------D----------------------------------A--TG--------KFALV------ -GRYAEKH---DEA-----------------------------------------------KQAQ--L---- LDRIR----------T-T-------D-H-A-LLGWKTTLLFLMRDQFLA--------------TNTCD---- -----FSLGTEE-FYD-EN-------------------------------------------------VALA VPQG-S-P-------------------------FLDKFNAE-----------LKRMQVGGLIQK-------- ---W---------------KMDYW-------------PR-------------K---DRCSVTAQGGGD---- ----------------------DATRTVSLADMQGSFVLLF-------------LGFLL-AAI----FIVVE CV---------------------------------YK-GW-------------------------------- ------------------------------------------------------------------------ ---------------------------------------KDKSKP--------------------------- ---------------------------------------------------GA------------------- -----------------------------------------------------H-STAT------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------MVK--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------P--FMA------------------------------ >Hame_1102315_IR93a/1-847 ------------------------------------------------------------------------ -----------------------------------MGNHRTLGTREWA-WV--CV-GVFLFLLATAAAQ--- ------------------------------------------------------------------LDNENS ------------------------------------------------------------------------ ----------------------ILGVYME------------------------------------------- -SGMVQGRRIPTQ------ELVEQVV-------TESSGAMTQ--------------------GSLTVQFLTS --MND-SMPE-EMTGVM--TLASCSNTHMWAPGLAEM---GKMHIALTE----------------------- --------------------------------------------------------------------SGCS R----------------------------IRHSTAITV-----------------PLTS-GS---------- --------------------RDLVQ--------VFRDLR--DKETLT------WTDIT-------------- --------------------------------------IIHD-ESV-------------------------- -----------------------DKLDVN--AIVSILAEGTAKSP-------------------DTAYSVVD LASVD--------------------ASSMKL-----------GKMFASLG-PQPGQPKN------------- 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---W---------------KQDYW-------------PR-------------K---NKCSSTAYGGG----- ----------------------DATRTVSLSDMQGSFFLLF-------------LGFVL-AAV----IIFGE WI---------------------------------LR-GW-------------------------------- ------------------------------------------------------------------------ ---------------------------------------RDKSNP--------------------------- ---------------------------------------------------GS------------------- -----------------------------------------------------RSSTGT------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------LVK--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------P--FMA------------------------------ >Csap_11023543_IR93a/1-841 ------------------------------------------------------------------------ ------------------------------------------MARAWV-WVWRCVWGV--SLLASAFAQE-- ------------------------------------------------------------------LDNENS ------------------------------------------------------------------------ ----------------------ILAVYME------------------------------------------- -SMLLEGTRGDTQ------QVIEKAV-------ADNLGVMKK--------------------GSVRVQMVDT --LNE-TMVE-GVTAVL--TLASCAGTHVWGKALADH---EKLHIALTE----------------------- --------------------------------------------------------------------SGCG R----------------------------INRGTAITV-----------------PITS-GA---------- --------------------NDLAQ--------VFKDMR--SRGTLT------WDDIT-------------- --------------------------------------VMHD-NSL-------------------------- -----------------------SNLEIQ--RIVNLLAEETPTIH-------------------ETAITMVD LSAV---------------------PSAMQR-----------RKMFSAFQ-PRAGEPKE------------- ------RQFLV-------ICY--KDALA-------------------------------------------- -----------------------EIQ-----------DMA------------RSL---GLMG---------- -----PK-NQWLFA----------------------------------------------VPDTHSL----- ------------------------------------------------------------------------ ----KYDMYAF----------------LANM----------------------------------------- ---------RDGDNLAFVY----NMSDINPTSPCQNGPN-----------CYIRL-LIANY-M--------- ----TATSEALVKEYDNFLQVSEE------------------------------------------------ -EWE-EVKPSPGARASKIVST---------------------------MKMAM------------------- -----------------------------------------------KDNNQCS------------------ -----------------RCTEWGVQAAET-------------------------------------KDVETF ELLNVADW-----------------------------------------------------APLHG------ --------------------------------------------LVLYDD---------------------- ---------------------------------------L------FPHV--------TGG----------- ----------FRGRT-IAVASVH------------------------------------------------- ---------------------------------------------------------Y-PP--------WQI -----------------------------------------FI----------------------------- -----------RDS-S-------------GRV--------------------------VRYEGLM-F----- ------------EVLKEMGA-K----------------------L----N----------F----------- ------------T----YVVRP-PPD---------GQ-WGV------------------------------- -----------------------------MDSSG---------------N---W------------------ NG------------------------MMR---MV--------------QN-N--------------E---VM LGVA-----------------------------------------------------------AFTVS---- -DKR---MRV--V-----------NF-T-SA-----IDLQP---YTF-------------M-IAR------- --------------------------------PQE-LS--RVM-------------LFMEP---FA------ ----------------------------------NDT--W-ILI-AIT-------VA-I---MG-----PIL FFINRS------------------------------------------------------------------ --------------------SPYY-T---------------------------------------------- ---------------------------------------Y-----------------YDLY----------- ------------------------------------------------------------------------ ----------------------------------DGKG-LF------------------------------- ---------------------------------KLHN-----CSWY---VYG--------AIL-----QQG- --------G-TKL-PLSNSGRLVVGF------WWI-----FVLIVVTTYSG-----NL-----VA-FLTFPQ I--EN-----------------------PVN-----TLDDLLKLK---------------------NTMS-- -----------WGYIG---------GTILE---------------DYF----Q------------------- -------------D----------------------------------A--EG--------KFLEV------ -GVDAEKH---EDS-----------------------------------------------KRAE--L---- YNRVR----------Y-T-------D-H-A-FLEWKTNLLFIMQDELFA--------------TDTCD---- -----FSLGREE-FYF-ES-------------------------------------------------VAMT VPRD-S-P-------------------------YLDHFNAQ-----------LKKMKVGGLIQK-------- ---W---------------KQDYW-------------PK-------------K---NKCSTTAYGGG----- ----------------------DATRTVSLSDMQGSFFLLF-------------IGFVL-AAV----IITGE CI---------------------------------MR-SF-------------------------------- ------------------------------------------------------------------------ ---------------------------------------IGKSEP--------------------------- ---------------------------------------------------GS------------------- -----------------------------------------------------RSSTGT------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------LVK--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------P--FMA------------------------------ >Hame_11751606_IR76b/1-689 ------------------------------------------------------MRGP-------------- -------------------------------------------------FGP-------------------- ------------------------------------------------------------------PSTPPP ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------S------------- ------STSS------------------------------APLLP--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------TVMR--GLVQYVTLG-----VC----------------WNMVGKL-- -HDSSLPLA----------------M---------------------------------------------- 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----------LQGRD-VPIALTN------------------------------------------------- ---------------------------------------------------------Y-PP--------FLH -----------------------------------------II-----R----------------------- ------------ER-G-------------G--------------------------NKVMGRGMS-W----- ------------ELMMTLAN-Y----------------------F----N----------F----------- ------------T----PVPLV-AED---------DV-IGL------------------------------- -----------------------------RSESG---------------E---W------------------ KG------------------------AMQ---LL--------------DS-K--------------V---AE LTLL-----------------------------------------------------------PVTIT---- -AAR---EEV--L-----------DF-S-LL-----LGTTT---FGI-------------L-AKR------- --------------------------------PKD-SP--KPD-------------ALLKP---FS------ ----------------------------------LEV--W-WLI-LAA-------TA-V---MG-----PLI YFIIVV------------------------------------------------------------------ --------------------RVRL------------------------------------------------ ---------------------------------------C-----------------KGDP----------- ------------------------------------------------------------------------ ----------------------------------RLTR-VF------------------------------- ---------------------------------PFDQ-----CVWF---VYG--------AMM-----KQG- --------S-MLK-PISDSSRILIAT------WWL-----FIMIVTSFYTA-----NL-----TA-FLTFNG L--KL-----------------------PIE-----KVEDLEN-L---------------------PGVS-- -----------WLAFR---------DGALV---------------DVI----T------------------- -------------------------------------------------T-HP--------KLKVL------ -RDLQAKG---RGR--------------------------------------------FINSRAE--A---- VALVR----------T-N-------E-Y-V-YIDDMQVLEYLIQEDFKT-------------QRRK------ -----EANETCS-FYT-TTLTS---------------------------------------DKGFTFWYGYG FRKD-S-E-------------------------YSDLFNGF-----------FRRLSFFGILNF-------- ---L---------------HDNVT-------------SN-------------S---PVCTLPKGF------- -----------------------KDRRLQNKDFYTTYVLGS-------------AGVLA-ALT----ALICE FV---------------------------------CR-KS-------R-R---------------------- ------------------------------------------------------------------------ -----------------------------------------TGRNM----------------------TPPT TTFTGRM--------------------------------------------GSTLGF--------------- ----------------------------------------------------GGSSQGVQ-DL--NW----- --------SSNLPPLPSMRPRTPF-------------EVRYPHYN--------------------------- ------------NRMSSSNT----------------------PAD--------GRNSKNVQMTISARQQQQH QQQQQQQRPRREKQHSHRTGNMFLETQRSPYIIEGKINNVNVL---WDQKSSKLIMQDVSKLNGNVA----- ------------------------------------------------------------------------ ----------------------------------------YIEGIP-------------------------- ------------------------------------YAFLQYNDTDGPKTQKMIL--------TDLI----- >Pcla_1729445_IR76b/1-588 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------MR--GVVWFVTLG-----VC----------------WDLAGRL-- -QDGRLTHA----------------LDNLSR-----------LNATTAA----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------TTTTT----TAATTTTTTTTTTTITLQLLNRV-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------LS SV---------------------------------------------------------------------- -----------------------------------------------VEE-DP------------------- -------------------------------------------------S--------HQD----------- 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--------------------RKKV------------------------------------------------ ---------------------------------------C-----------------EKDT----------- ------------------------------------------------------------------------ ----------------------------------VLNR-VF------------------------------- ---------------------------------PLDE-----CMWF---VYG--------SMM-----RQG- --------T-ELK-PISDSSRILFAT------WWL-----FITIVTSFYTA-----NL-----TA-FLTFNG L--QL-----------------------HIT-----RVEDLRK-----------------------HHVT-- -----------WLAFR---------DGALV---------------EVI----S------------------- -------------------------------------------------T-HP--------KLQIL------ -RDLQAEG---RGR--------------------------------------------FIDSRAE--A---- VSLVR----------T-N-------D-Y-V-YIDDMQVLDHLMQEDFKT-------------QRRV------ -----GAKETCS-FYS-TPLASGD-------------------------------------DVDFVFWFGYG FRKG-S-D-------------------------LTPLFNGF-----------FRRLAFFGILNF-------- ---L---------------HDNVT-------------SN-------------S---PICTMPKGF------- -----------------------KDRSLQNKDFYTTYVLGA-------------IGIVL-AAG----ALGCE CL---------------------------------VR-RA-------R-R---------------------- --------------------CR-------------------------------------------------- ------------------------------------HDQDDLDAD------------------------YPT THLPDNV--------------------------------------------PSILG---------------- -----------------------------------------------------VESIGVKHDP--IWG---- --------SANLPPLPDTRARTPF-------------HVRYPQYS--------------------------- ------------H----------------------------------------GRHGQ-------------- --------------------------------------------------------------ASDAA----- ------------------------------------------------------------------------ ----------------------------------------FVRP---------------------------- ------------------------------------------------------------------------ >Csap_1505292_IR76b/1-738 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------MQ--SLVRYVTLC-----VC----------------WGCVGEMTG THIANMALS----------------AHGQPI-----------SNSNTQAH-AIFSQP--------------- ------------------------------------------------------------------------ ------------------------------------------------------------LQ---------- -----TH-DSPIQI----------------------------------------------LPDQSPV----- ------------------------------------------------------------------------ ----PSHGQPLHSHDTPLHTLPEPPVVALDQ----------------------------------------- ---------PPDSETTIRI----LPEQVPLPAPSHGQRSFQVLKRI-------------------------- ------------------------------------------------------------------------ ------DAPDYDPEAVVLSEP---------------------------SQR--------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------SEELV SLLEAEGL---------------------------------------------------------------- ----------------------------------------------EGEE-KI------------------- -------------------------------------------------V--------QQN----------- ----------LEGRP-IKIALAN------------------------------------------------- ---------------------------------------------------------Y-PP--------FLE -----------------------------------------IT-----Q----------------------- -------------S-G-------------GP-------------------------DGIKGRGMS-W----- ------------DVMNALAS-Y----------------------F----N----------F----------- ------------T----PEPVA-APD---------NL-VGV------------------------------- -----------------------------KGKNG-------------------W------------------ KG------------------------ALQ---LI--------------AN-E--------------E---AE FTLM-----------------------------------------------------------PVTVT---- -EVR---KEV--V-----------EF-S-HL-----LGTTS---FGM-------------L-VRR------- --------------------------------PEY-TP--KPD-------------ALLKP---FN------ ----------------------------------KEV--W-FWI-IGS-------MA-T---MG-----PLI YFIIVF------------------------------------------------------------------ --------------------RVRL------------------------------------------------ ---------------------------------------C-----------------RGDP----------- ------------------------------------------------------------------------ ----------------------------------RLTR-IM------------------------------- ---------------------------------PFDQ-----CCWF---VYG--------AMM-----KQG- --------S-VLK-PISDSSRILFAT------WWL-----FIMIVTSFYTA-----NL-----TA-FLTFNG L--QL-----------------------PIN-----EVADLEK-Y---------------------SKVT-- -----------WLASR---------DGAVV---------------DII----T------------------- -------------------------------------------------S-HP--------QLEIL------ -RELKKKG---RGR--------------------------------------------YINSRDE--A---- LALVR----------T-G-------D-Y-V-YIDDVQVLEYLIQEDFKR-------------QQRE------ -----EVNQTCN-FYT-SELEK---------------------------------------GGELTFWYGFG FKNG-S-E-------------------------YTDLFNGF-----------FRRLSIFGILNF-------- ---L---------------RNSAT-------------SS-------------S---PVCTLPKGF------- -----------------------KDRALENKDLYTTYVLYA-------------IGVVA-SLL----ALLTE SF---------------------------------FR-RA-------M-R---------------------- --------------------QT-------------------------------------------------- ------------------------------------HSLAMATKKTFSSRF----------------NSPPI KVTPSRI--------------------------------------------GP------------------- -------------------------------------------------------------AQ--DW----- --------SSGVPPLPETRLRTPF-------------EVKYPQFA--------------------------- ------------NLKPQYTPQ--------------------IPGARQVP---YGQPSG-------------- --------PR---------------------IISGKINDVDVK---WDQQEGKLLLQDAKQLSGNVA----- ------------------------------------------------------------------------ ----------------------------------------YIDGVP-------------------------- ------------------------------------YAFLHYRDEDGPKLQKLIL--------SDLI----- >Csap_1303293_IR25a/1-936 ----------MAW---------------------------------------VAMG--------QSS----- ---------------------------------------------GER-----DLLVLYLAAVTLSLV---- ----------------A---AQ-------------------------------------------------T SVNI-------------------------------------------------------------------- -------------------------MVMHEVEN--------------------------------------- ---------------VQATQGIVAAV-----------KYLEKNTGE----------------G-VKLGS--- --QVFIPLKKGDDVEAT--VNETCAKLDEAIAAN--T-KPHIVL---------------------------- ---------------------------------------------------------------------DAT STGL--------------------ISETVKSFTRALAL-----------------PTFSASYGQEGDIREWR DLTEEEEQYLVQA---MPPGDILVM--------AVRDI---VET-QN------ITNA--------------- -----------------------------A--------IIYD-ETFV------------------------- ---------------------------MD--HKYKSLLLNL-----------------------PCRHILTQ AED---------------------TE--MAL-----------RKQTKRLMDADIVN---------------- 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----------QAVTV-YRVTTVR------------------------------------------------- ---------------------------------------------------------Q-AP--------FIM ------------------------------------------------------------------------ ---------QKTNE-D-------------GE---------------------------TEFYGYC-I----- ------------DLINEIKE-I----------------------V----E----------F----------- ------------E----YEIYE-APD---------GK-FGT------------------------------- -----------------------------MSETM---------------E---W------------------ DG------------------------MIK---EL--------------IE-K--------------R---AD IALA-----------------------------------------------------------PLSVM---- -AER---ENV--V-----------DF-T-VPY----YDLVG---ITI-------------L-MKK------- --------------------------------PKV-PT--SLFK-------------FLTV---LE------ ----------------------------------PEV--W-VCI-LFA-------YG-F---TS-----VLL YVFDRF------------------------------------------------------------------ --------------------SPYS-YQN-------------------------------------------- -----N------------------------------KEKY-----------------KDD------------ ------------------------------------------------------------------------ ----------------------------------DEKR-EF------------------------------- ---------------------------------TFKE-----CLWF---CMT--------SLT-----PQG- --------GGEA--PKNLSGRLVAAT------WWL-----FGFIIIASYTA-----NL-----AA-FLTVSR L--DT-----------------------PIE-----SLDDLSKQY----------------------KVQ-- -----------YAPLN---------GSSTQ---------------TYF----E------------------- -------------RMAYIEHKFYEIWKDMSLNDSMSPVERAKLAVWDYPV-SD--------KYTKM------ -WQSMQEA---GL----------------------------------------------PTTLAG--A---- VERVRKSTSS-----S-E-------G-F-A-YIGDATDIRY--------------------LELTSCD---- -----LQIVGEE-FSR-KP-------------------------------------------------YAVA VQQG-S-P-------------------------LKDQFNDA-----------ILKLLNQRKLET-------- ---L---------------KERWW-------------NQ-------------NPEKKVCEKDDDQ------- ------------------------SDGISIENIGGVFIVIF-------------VGIGL-ACV----TLAFE YW---------------------------------WY-KH-------R-KGP-------------------- ------------------------------------------------------------------------ ------------------------------------RVTD-SGRVVN------------------------V K----------------------------------------------------------------------- ------------------------------------------------------------------------ --------------S--------------------------------------------------------- ----------------------------------------------DMA---KTNFGHR------------- ---------------------------------------------------EKSNFQAEYNNTGEN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------DFNIA----------------------PVGNPW-------------------------------- >Pcla_11170659_IR25a/1-937 -----------------------------------------------------MMS--------QQDNFLHT TMTR----------------------------------------PGAA-----LRLSLMLLLLPGTL----- --------------------AQ-------------------------------------------------Q KVNI-------------------------------------------------------------------- -------------------------MVLREEGN--------------------------------------- ---------------APAEQGLKAAI-----------DYLKKNQAE----------------G-VVVDR--- --MDVMVIKKGSDIEGT--VNATCDLMDGAITAS--K-PPHIIL---------------------------- ---------------------------------------------------------------------DMT TTGM--------------------MAETAKSFTRALAL-----------------PTFSASYGQEGDIREWR TLTSNESKYLVQL---MPPGDIIVQ--------AIRDI---VRT-QN------ITNA--------------- -----------------------------G--------IIYD-DTFV------------------------- ---------------------------ME--HKYKSLLMNL-----------------------PCRHIMTM VEA---------------------TD--NLV-----------RNQTMRLKNADIVN---------------- --------FFA-------VGR--QKTIS-------------------------------------------- -----------------------RIL-----------DAA------------TAN---GMFG---------- ----RKY--AWYAL----------------------------------------------SKD--------- ----------------------------------DDDVQCG---------CENATVVYLRPRAS-------- ----ADTRGRLAMLQKDFQLTAT-----PEI----------------------------------------- -------------DSAFYF----D--------------------------YAIR--GIKAA-G--------- ----TLAASGA-------------------------------------------Y-SNITYIKCE------- -AFK-EDNPPVRPD-FDLLSA---------------------------LKSVA------------------- -----MTSTWGSVKW------------------------------GGNGMTFLD------------------ -------------------LPVTMDKFLILR-------------------------------------GKTA DRKTLGDW--------------------------------------------------MTGMP--GT----- --------------------------------------------FMF------------------------- ----------------------------KAGQSL------------------------QDY----------- ----------QAVTV-YRVTTVQ------------------------------------------------- ---------------------------------------------------------Q-PP--------FVY ------------------------------------------------------------------------ ---------KKINA-D-------------GK---------------------------PEFYGYC-I----- ------------DLINEIKL-I----------------------V----N----------F----------- ------------E----YEISE-APD---------GK-FGT------------------------------- -----------------------------MDDNQ---------------Q---W------------------ NG------------------------MIK---QL--------------VD-K--------------Q---AD IALA-----------------------------------------------------------PLSVM---- -AER---ENV--V-----------DF-T-VPY----YDLVG---ITI-------------L-MKK------- --------------------------------VKL-PT--SLFK-------------FLTV---LE------ ----------------------------------PEV--W-ICI-LVA-------YG-F---TS-----VLL YIFDRF------------------------------------------------------------------ --------------------SPYS-YQN-------------------------------------------- -----N------------------------------REKY-----------------KDD------------ ------------------------------------------------------------------------ ----------------------------------EEKR-EF------------------------------- ---------------------------------NLKE-----CLWF---CMT--------SLT-----PQG- --------GGEA--PKNLSGRLVAAT------WWL-----FGFIIIASYTA-----NL-----AA-FLTVSR L--DT-----------------------PIE-----SLDDLSNQY----------------------KVQ-- -----------YAPVN---------GTSTM---------------TYF----E------------------- -------------RMAYIEKKFYEIWKDMSLNDSMSDVERAKLAVWDYPV-SD--------KYTKM------ -WQSMQEA---GL----------------------------------------------PTSLEA--A---- LERVRKSTST-----S-E-------G-F-A-YLGDATDIRY--------------------QVLTNCD---- -----LQIVGEE-FSR-KP-------------------------------------------------YAVA VQQG-S-P-------------------------LKDQFNDA-----------ILKLLNQRKLET-------- ---L---------------KERWW-------------NQ-------------NPAKKMCEKDDDQ------- ------------------------SDGISIENIGGVFIVIF-------------VGIGL-ACV----TLAFE YW---------------------------------WY-KH-------R-KGP-------------------- ------------------------------------------------------------------------ ------------------------------------QVAD-SSKVVA------------------------V RE---------------------------------------------------------------------- ------------------------------------------------------------------------ -----------LPHS--------------------------------------------------------- ----------------------------------------------DTK---A------------------- ---------------------------------------------------NKANFSTQYNSGRDG------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------YNIS----------------------PVANPW-------------------------------- >Hame_11119524_IR25a/1-936 ------------------------------------------------------MA--------SQTQVI-- ---------------------------------------------GRA-----WLFTL--LCLSTTLV---- ----------------TVIHAQ-------------------------------------------------Q KINI-------------------------------------------------------------------- -------------------------FMTYDEDN--------------------------------------- ---------------MLVKQSLDAAI-----------SYLEKNTGE----------------G-AMVDG--- --KHIYAIPKGNDVEVT--VNKSCDLMDEAIDAG--K-PPHIVL---------------------------- ---------------------------------------------------------------------DAT TTGM--------------------ISETIKSFTRALTL-----------------PTFSASYGQEGDIREWR KLTPSEEEYLVQL---MPPGDIIVQ--------SIRDI---VRT-QN------ITNA--------------- -----------------------------G--------IIYD-DTFV------------------------- ---------------------------ME--HKYKSLLQNL-----------------------PCRHIMTR VEA---------------------TE--KEV-----------RRQTKRLKDADIVN---------------- --------YFA-------VGS--GDTIS-------------------------------------------- -----------------------RIL-----------DAA------------TAN---DMFG---------- ----RKY--AWYAL----------------------------------------------SKD--------- ----------------------------------NQDIQCG---------CENASIVYLRPHTS-------- ----ADSRGRIAMLQRDYGLTST-----PEI----------------------------------------- -------------DAVAYF----E--------------------------YFMR--GILGA-A--------- ----KMAAAGK-------------------------------------------Y-TDFEYLRCE------- -EFS-EDNPPVRND-FDLRSA---------------------------LQSVS------------------- -----MTNTWASISW------------------------------GSNGMSYPD------------------ -------------------VPLTMDKFKILA-------------------------------------GRTA ERKTLGEW--------------------------------------------------SAGMP--GT----- --------------------------------------------LMF------------------------- ----------------------------KSGQTL------------------------SDF----------- ----------QAVTV-YRVTTVQ------------------------------------------------- ---------------------------------------------------------Q-PP--------FIM ------------------------------------------------------------------------ ---------KRTNE-D-------------GE---------------------------DEYYGYC-I----- ------------DLINEIKE-I----------------------I----N----------F----------- ------------E----YEIAE-APD---------GK-FGT------------------------------- -----------------------------MDDNH---------------E---W------------------ NG------------------------MIK---QL--------------IE-K--------------R---AD IALA-----------------------------------------------------------PLSVM---- -AER---ENV--V-----------DF-T-VPY----YDLVG---ITI-------------L-MKK------- --------------------------------PKV-PT--SLFK-------------FLTV---LE------ ----------------------------------PEV--W-LCI-LFA-------YG-F---TS-----VLL YIFDRF------------------------------------------------------------------ --------------------SPYS-YQN-------------------------------------------- -----N------------------------------KERY-----------------KDD------------ ------------------------------------------------------------------------ ----------------------------------DEKR-EF------------------------------- ---------------------------------NLKE-----CLWF---CMT--------SLT-----PQG- --------GGEA--PKNLSGRLVAAT------WWL-----FGFIIIASYTA-----NL-----AA-FLTVSR L--DT-----------------------PIE-----SLDDLSNQY----------------------KVQ-- -----------YAPMN---------GTSTM---------------TYF----E------------------- -------------RMAYIEKKFYEIWKDMSLNDSMSDIERAKLAVWDYPV-SD--------KYTKM------ -WQSMQEA---GL----------------------------------------------PITFEA--V---- LERVRKSTSS-----S-E-------G-F-A-YLGDATDIRY--------------------QVLTNCD---- -----LQIVGEE-FSR-KP-------------------------------------------------YAIA VQQG-S-P-------------------------LKDQFNDA-----------ILKLLNQRKLET-------- ---L---------------KERWW-------------NQ-------------NPEKKVCEKDDDQ------- ------------------------SDGISIENIGGVFIVIF-------------VGIGL-ACV----TLAFE YW---------------------------------WY-KH-------R-KGP-------------------- ------------------------------------------------------------------------ ------------------------------------RVTD-SAKVLA------------------------V RE---------------------------------------------------------------------- ------------------------------------------------------------------------ -----------YPTN--------------------------------------------------------- ----------------------------------------------DVD---KTNFNP-------------- ---------------------------------------------------EKSDFNTQYNT-GEG------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------FDIA----------------------PVANPW-------------------------------- >Csap_11000338_IR8a/1-855 ------------------------------------------------------MR--------NAD----- ---------------------------------------------RGS-----SPYWLSSVIL--------- ----------------LMFLAQRTSAQL-------------------------------------------- --TLI------------------------------------------------------------------- -------------------------STIDESMA--------------------------------------- ----------------EGVAWLEEAV-----------KAAETSSGL----------------T-IKQE---- --VIMTSLDKEED---N--EQQFCSSLF--------S-GAALVL---------------------------- ---------------------------------------------------------------------DVT AGG----------------------WTFAQETAAAHGI-----------------PYVRVQVS--------- -------------------NYQWLA--------ATDNL---LQS-RN------ATDA--------------- -----------------------------A--------LIFG-SEAE------------------------- ---------------------------LD--QALYYLVEGS-----------------------VVRVIVLS -------------------------GIDDKT-----------TTTLRKMRPAP-SY---------------- --------YVI-------LAA--TDRLT-------------------------------------------- -----------------------ALF-----------NQA------------KRR---NLVT---------- ----RDS--RWTLV----------------------------------------------AMDYGA------ ---EDFDRTMLAGSTG--ITLVTPTREVCCVA-RNTQSFCD---------CNN------------------- ------------------------------L----------------------------------------- -----------VVPKAITL----N--------------------------------AVLML-V--------- ----RILKAEG---------------------------------------------QQDVAGTCD------- -APP-D-TPPSTTSFYTALQT---------------------------ELG--------------------- --------SWPGIKW------------------------------RFDKMQMEP------------------ ------------------RLAFNIQA------------------------------------------INST ASQTVGSW--------------------------------------------------STDSG--------- ------------------------------------------------------------------------ ---------------------------LQLIPGF------------------------EHS----------- ----------PIRRH-FRLGTIL------------------------------------------------- ---------------------------------------------------------S-RP--------WVS -----------------------------------------VV-----KKGMA------------------- ------EGEKM-LS-T-------------DP---------------------------KDYVGYC-V----- ------------DLAERLAK-E----------------------M----K----------F----------- ------------D----YDFRF-PED---------GQ-YGV------------------------------- -----------------------------RQKDG---------------T---W------------------ NG------------------------LVG---DL--------------SN-G--------------V---TD IIVA-----------------------------------------------------------PLTMT---- -SER---EEV--I-----------DF-V-APY----FDQSG---ISI-------------V-IRK------- --------------------------------RQR-EE--SLFK-------------FMTV---LR------ ----------------------------------AEV--W-VSI-VAA-------LV-V---TG-----IMI WLLDRY------------------------------------------------------------------ --------------------SPYS-AQN-------------------------------------------- -----N------------------------------SALY-----------------P-------------- ------------------------------------------------------------------------ ----------------------------------PNCR-KF------------------------------- ---------------------------------TLKE-----SFWF---ALT--------SFT-----PQG- --------GGEA--PKALSGRTLVAA------YWL-----FVVLMLATFTA-----NL-----AA-FLTVER M--QT-----------------------PVS-----SLDELARQS----------------------KIN-- -----------YTVLQ---------STAVF---------------QYF----E------------------- -------------NMGAAEEELYRVWKELTLN---STSDQSKYRVWDYPI-KE--------QYTHI------ -LQVIVDS---KP----------------------------------------------VLQAEE--G---- FQRVLKNEKG-----E-----------F-A-FIHDASEIRY--------------------EVLQDCQ---- -----LTEVGEP-FAE-QP-------------------------------------------------YAIA VQQG-S-H-------------------------LQDEISRA-----------ILELQKDRYFEA-------- ---L---------------TAKFW-------------NR-------------T-ERGACPDDSD-------- ------------------------SEGITLQSLGGVFIATL-------------IGLAL-AMV----ALAVE VL---------------------------------YY-KR-----------GKG------------------ ------------------------------------------------------------------------ -----------------------------------SHVSD--ITPR-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------KPLKMVP-------------- ------------------------------------------------------------------------ ------------------------------------------DKHHVS------------------------ -------RINVT----------------------PVY----------------------------------- >Hame_11456044_IR8a/1-846 ------------------------------------------------------MR---------------- ------------------------------------------------------------VLLAAPLSC--- ----------------LLLLVPTALAQI-------------------------------------------- --TIV------------------------------------------------------------------- -------------------------SILDESLQ--------------------------------------- ----------------EGVSWLEEAV-----------SQAQRKTGL----------------S-LSQE---- --IVKVSLDNEND---G--KDKLCSALY--------N-GVAVVM---------------------------- ---------------------------------------------------------------------DMT AGG----------------------WTHARDTAAAHGV-----------------PYLRLQVS--------- -------------------NYQWMA--------ATDDL---LRS-RN------ATDA--------------- -----------------------------A--------LIFG-SEAQ------------------------- ---------------------------LD--QALYYLVEGS-----------------------VVRVIVLS -------------------------GVDEST-----------TETLKKMRPSP-SY---------------- --------YVI-------LGT--TEELS-------------------------------------------- -----------------------KLF-----------TKA------------VQN---KLVT---------- ----RDS--RWTLV----------------------------------------------ATDHKQ------ ---DDFDRGLLMGSTG--VTMMTPVEEVCCTV-RNRQNFCD---------CDS------------------- ------------------------------L----------------------------------------- -----------VIPKELTV----N--------------------------------TMLTL-T--------- ----KALKANG---------------------------------------------ATNVQGTCE------- -EPV-T-DPPSTASFYSAFQT---------------------------ELG--------------------- --------SWPNVVW------------------------------NADKLQTVP------------------ ------------------ELKFDIIA------------------------------------------INSS ATSVVGSW--------------------------------------------------NTSKE--------- ------------------------------------------------------------------------ ---------------------------LVLNPQY------------------------EHS----------- ----------PIRRH-FKIGTIM------------------------------------------------- ---------------------------------------------------------S-RP--------WVS ------------------------------------------------PKTGK------------------- ------EGESS-SS-I-------------DP---------------------------ANYIGYC-V----- ------------ELSARLAE-H----------------------M----K----------F----------- ------------D----FELKF-PDD---------GQ-YGA------------------------------- -----------------------------RQKNG---------------S---W------------------ NG------------------------LVG---DL--------------SN-G--------------V---TD IIVA-----------------------------------------------------------PLTMT---- -SER---EEV--I-----------DF-V-APY----FDQSG---ISI-------------V-IQK------- --------------------------------RQR-EE--NLFK-------------FMTV---LR------ ----------------------------------AEV--W-VSI-VAA-------LV-V---TG-----IMI WLLDRY------------------------------------------------------------------ --------------------SPYS-AQN-------------------------------------------- -----N------------------------------PDLY-----------------P-------------- ------------------------------------------------------------------------ ----------------------------------PQCR-KF------------------------------- ---------------------------------TLKE-----SFWF---ALT--------SFT-----PQG- --------GGEA--PKALSGRTLVAA------YWL-----FVVLMLATFTA-----NL-----AA-FLTVER M--QS-----------------------PVQ-----SLEALAHQA----------------------KIN-- -----------FTTTR---------NSAIY---------------EYF----H------------------- -------------NMAKAEDELFRVWKELTLN---STSDQSKYRVWDYPI-KE--------QYTHI------ -LQVIQES---GP----------------------------------------------VERAKF--G---- FEKVLKDKNG-----E-----------F-A-FIHDASEIRY--------------------EVYHNCL---- -----LTEVGEP-FAE-QP-------------------------------------------------YAIA VQQG-S-H-------------------------LQDEISRA-----------ILELQKDRYFEA-------- ---L---------------SAQFW-------------NS-------------S-ARGSCPNDND-------- ------------------------SEGITLQSLGGVFIATL-------------IGLAL-AMI----ALAAE VL---------------------------------YY-KR-----------GGT------------------ ------------------------------------------------------------------------ -----------------------------------TLVSD--LPPK-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------MALKKAS-------------- ------------------------------------------------------------------------ ------------------------------------------EKDHIS------------------------ -------RINVT----------------------PVY----------------------------------- >Pcla_11512556_IR8a/1-722 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------MA--------ATDQL---LES-RN------ATDA--------------- -----------------------------A--------LIFG-SEAE------------------------- ---------------------------LD--QALYYLVEGS-----------------------AVRVIVLA -------------------------GVDQST-----------TEMLKKMRPSP-SY---------------- --------YVI-------LGT--TDHLS-------------------------------------------- -----------------------LLF-----------SKA------------VEK---SLVT---------- ----RDS--RWTLV----------------------------------------------ATDHKS------ ---HQFDRGALRGLQS--VTLVAPAQEVCCTV-RNRQSLCD---------CDT------------------- ------------------------------L----------------------------------------- -----------IISREMTM----N--------------------------------SMLTL-T--------- ----NVLKGNA---------------------------------------------GKNVRGSCG------- -ETP-P-NPPSTTSFYSALQT---------------------------SLR--------------------- --------EWRQVEW------------------------------EADKLQVVP------------------ ------------------QLKLDITA------------------------------------------INTS TSSALGSW--------------------------------------------------STSEK--------- ------------------------------------------------------------------------ ---------------------------LQLNPQF------------------------KNS----------- ----------PIKRH-FKIGTVM------------------------------------------------- ---------------------------------------------------------A-RP--------WVS ------------------------------------------------SKSES------------------- ------PGDQ-------------------------------------------------QYEGYC-V----- ------------ELAARLAL-Y----------------------M----N----------F----------- ------------D----YEFKF-PED---------GQ-YGV------------------------------- -----------------------------RQNNG---------------S---W------------------ NG------------------------LVG---DL--------------SN-G--------------V---TD IIIA-----------------------------------------------------------PLTMT---- -SER---EEV--I-----------DF-V-APY----FDQSG---ISI-------------V-IRK------- --------------------------------RQR-EE--SLFK-------------FMTV---LK------ ----------------------------------PEV--W-VSI-VAA-------LV-V---TG-----IMI WLLDRY------------------------------------------------------------------ --------------------SPYS-AQN-------------------------------------------- -----N------------------------------ADLY-----------------P-------------- ------------------------------------------------------------------------ ----------------------------------PHCR-KF------------------------------- ---------------------------------TLKE-----SFWF---ALT--------SFT-----PQG- --------GGEA--PKALSGRTLVAA------YWL-----FVVLMLATFTA-----NL-----AA-FLTVER M--QT-----------------------PVS-----SLDELAGQS----------------------KIN-- -----------YTVLQ---------SSAIY---------------QYF----A------------------- -------------NMAAAEEELYRVWKELTLN---STSDQSKYRVWDYPI-KE--------QYTHI------ -LQVIDQS---GP----------------------------------------------VERAQL--G---- FDKVLKNKDG-----D-----------F-A-FIHDASEIRY--------------------EVYHNCL---- -----LAEVGEP-FAE-QP-------------------------------------------------YAIA VQQG-S-H-------------------------LQDEISRA-----------ILELQKDRYFEA-------- ---L---------------SAQFW-------------NS-------------S-ARGTCPNDND-------- ------------------------SEGITLQSLGGVFIATL-------------IGLAL-AMI----ALAAE VL---------------------------------YY-RR-----------GGV------------------ ------------------------------------------------------------------------ -----------------------------------SLVTD--LTPK-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------AAFKLTS-------------- ------------------------------------------------------------------------ ------------------------------------------EKDRVS------------------------ -------RINVI----------------------PAY----------------------------------- >Csap_1621767_IR21a/1-649 ------------------------------------------------------------------------ -------------------------------------------------------MSIFSEMVVQ------- -------------------------------------------------------------------NSIPE VYLNS------------------------------------------------------------------- ------------------------------------------------------------------------ -----------TYGTSSSLQLWWSIV---------------------------------------------- -----------------------------------------SLLLAVTQD---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------RNG--------------------------------- ------------------------GKCALA--------ITFD-PTFL------------------------- --------------------PAVDMFLTT--QMKEFGNGTSGHPVILMRLMTSLESEHKTSEEEL------- -------------------------------------------HSLQQHY-GRLGQDMC------------- ------THYLF------LVQR--LSPLL-------------------------------------------- -----------------------RLL-----------KVL------------YKE---SLNL---------- ----HGK-F--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------ILITR---------A---------------------------- ---------KKHELVKFIEATPINK----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------IVQLVIA----------------- ---------------------------------------------CPSPTVDL------------------- -----------------GVLRLQLYTHAFF------------------------------------NQ-NRT SLRYLGLW--------------------------------------------------PPVINTTRI----- ---------------------------------------------------S-------------------- ---------------------------------------F------FPDK--------LRN----------- ----------FNGYK-FRATTFN------------------------------------------------- ----------H------------------------------------------------PP--------VSI -----------------------------------------FE----------------------------- -----------GQP-----------------------------------------DGKIYYDGLE-I----- ------------RLLYTLAK-A----------------------L----N----------F----------- ------------T----VQISQ-PRDG--------EK-WGT------------------------------- -----------------------------RLLDG---------------N---W------------------ TG------------------------AMG---ET--------------MR-G--------------E---TD ISFA-----------------------------------------------------------NYFIT---- -ADR---LRI--I-----------DM-T-RP-----YYIDY---TCF-------------I-TPK------- --------------------------------PQP-LP--QYS-------------AVAWP---FT------ ----------------------------------GMV--W-AVV-LVT-------LL-I---IP-----PVV LLTGFL------------------------------------------------------------------ -------------------EP--G------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------E----WFR------------------------------ ---------------------------------QISN-----VELY---VVG--------IFLN---RAHP- --------V-HLV-PSSSGLRVLVIT------NWI-----AAMVLAVAYKS-----SL-----IA-FLTVPL Q--AS-----------------------PVN-----TLEELL-----------------------SSGLD-- -----------WGVRD---------RGGWD---------------EWF----S------------------- -------------N----------------------------------SL-DP--------TSRKI------ -AEGFQ----------------------------------------------------YVEGIEG--G---- LARVM----------E-G-------N-F-A-FMNSGTFLRYLIASSYTDE-------------FGETK---- -----LHIAKQC-FVP------------------------------------------FR--------IGLG MPLF-S-I-------------------------YTARFNDV-----------VAKVVEAGLVSQ-------- ---W---------------FKDLL-------------ST-------------AEKKQRNNLKENMEETDSKI --------------------HLKKSMNLWLYHVQGAFYLLL-------------LGWLM-SWT----VFSLE MI---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------T---RKKR---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_11825415_IR21a/1-786 -----------------LD-----------HSP-----------------------QSPG------------ -------------------------------------------------QGE-ENTHSNKDLTQA------- -------------------------------------------------------------------KTAPQ TTVPD------------------------------------------------------------------- ------------------------------------------------------------------------ -----------RPNTNDALQPNYSPVVKGHHH--------------------------QP------------ --PSVAAAGSVVDPAVL--LTKEL----------------KKELVGTRQDEV---------------NLHHR EDLHD--------------------------------------------------GDLDNSFYDELPYTESL HSGA-----------------DGD-VVMEEGVSREVAS---------------------------------- ----------------------LVE--------SVRRQGM-------------------------------- ------------------------GRCALA--------VTTD-HHHL------------------------- --------------------PALHLLLTQ--HLAAEDVENLHHP-------------HQQEEQEVTPIALFT LPPLS-------------------QDNSTTF-----------PSSLAEKY-KSVGRETC------------- ------VHYVF------LVSD--PSRLL-------------------------------------------- -----------------------HLL-----------AGL------------YQD---ALYL---------- ----WAK-F--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------VLVTH---------L---------------------------- ---------HVHHILDFLQTSPVNK----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------IVQVLLV----------------- ---------------------------------------------TPSASQD-------------------- -----------------GV-ALHLYTHLFFL-----------------------------------EQ-RRL TLKKLGTW---------------------------------------------------PLRNSSST----- ---------------------------------------------------SSTSSTSS------------- -------------------------SAGKVRGAL---Q-F------FPEK--------LSN----------- ----------FNGFR-FRVTTFN------------------------------------------------- ----------H------------------------------------------------PP--------VSI -----------------------------------------FE----------------------------- -----------SLP-----------------------------------------DGDITYDGLE-I----- ------------RLLSALAS-A----------------------L----N----------F----------- ------------T----VEINL-PRDG--------EK-WGS------------------------------- -----------------------------RLPNG---------------S---W------------------ TG------------------------AVG---ET--------------IR-G--------------E---TD VSFA-----------------------------------------------------------NYFIT---- -ADR---LKV--M-----------DM-T-ES-----YYIDY---ACF-------------I-TPK------- --------------------------------PQP-LP--QYT-------------AVAWP---FH------ ----------------------------------VSV--W-GAV-LVT-------LM-M---VP-----PAV RVAGLV------------------------------------------------------------------ -------------------EP--G------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------S----WFR------------------------------ ---------------------------------RLDN-----AFWY---VLG--------VFLT---RSQP- --------F-QLV-PSSSGLRVVVIT------SWV-----AAMVISVAYKS-----SL-----IA-FLMVPL P--AQ-----------------------PIN-----TLAQLL-----------------------ESGLR-- -----------WGVRD---------RGGWD---------------EWF----S------------------- -------------N----------------------------------SL-DP--------TSQKI------ -AAGFE----------------------------------------------------FVNGIER--G---- LARVL----------E-G-------N-F-A-FMNSGTFLRYLVASNFTDE-------------FGQTE---- -----LHIAKQC-FVP------------------------------------------FR--------IGLG MPRF-S-V-------------------------YTSRFNSV-----------VAHVVEAGMVSR-------- ---W---------------FQDLL-------------DK-------------AERKQSNKARDRRETLQTDT --------------------YSTQTKVLGLYHVQGPLILLV-------------LGWVL-AGT----TFLLE VA---------------------------------LC----------------------------------- ------------------------------------------------------------------------ ---------------------------------S-------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------ST---RRRCWQPS------------ -------------------------------------------------------VADDETED--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla11507602_IR21a/1-310 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------LFLQHN EGGS-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------GGSEEEQVCPVTVFT LPPPS-------------------QEDGGPL--------------LASQY-LRVGQETC------------- 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----------FHGFT-FRATTFD------------------------------------------------- ----------Y------------------------------------------------RP--------FTI -----------------------------------------LE----------------------------- -----------RGP-----------------------------------------GGRATYDGLE-I----- ------------RLLQTLAS-A----------------------L----N----------F----------- ------------T----LEIHQ-PADG--------EK-WGS------------------------------- -----------------------------RLANG---------------S---W------------------ TG------------------------AVG---ET--------------VR-G--------------E---TE VSFA-----------------------------------------------------------NYFIT---- -ADR---LKI--M-----------DM-T-RP-----YNIDY---TCF-------------V-TPK------- --------------------------------PRPGDA--QYT-------------AVTSP---FQ------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------VRGCDA------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----E-V-------------------------YN------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >XP_026839293.1_Dere_Kainate2/1-799 ------------------------------------------------------MF---------------- ---------------------------------------------------------IANGLLLL------- ----------------QFIS---------------------------------------------YASGVPP LVRVG------------------------------------------------------------------- -------------------------AIFSNHPGM-------------------------------------- ---------------YNSEMAFRYAI-----------HRLNMDKSL------------------LPETTV-- --DYYIEYVNRFDSFET--VQKVCK-LI--------RVGVQAIF---------------------------- ---------------------------------------------------------------------SPT -DSV--------------------LATHINSVCDALDI-----------------PNI---GR--------- ----SAHDFSINV---YPSQKYVNY--------AFNDV---IQY-LN------WTRF--------------- -----------------------------G--------ILHE-KENG------------------------- ------------------------ILNLH--QLSRSFHGEV-----------------------HMRQV--- --------------------------SRGSY-----------LSALNEFKGKEIHN---------------- --------III-------DTN--SNGIS-------------------------------------------- -----------------------ILL-----------KNI------------LQQ---QMNE---------- ----YKY--HYLFT----------------------------------------------SFDLEAY----- -DLEDFKYNFV------NITSFRLVD------------------------TGDVGVKQILKDIG-------- ----FYSHHMLKKPFFNLHVQKS-----TIL----------------------------------------- -----------ESEPALMF----D--------------------------------SVYVF-A--------- ----IGLQ--TLEQSH---------------------------------------SLTFSNISCD------- ------EEIP-WNGGLSLINY---------------------------LNAVEWK----------------- -------GLTGPIQFKD-GQ---------------------------------------------------- ------------------RVQFKLDLIKLKQ--------------------------------HS------- -IVKVGEW--------------------------------------------------TPHG---------- ---------------------------------------------HLNIT-EPSMFFDA------------- ----------------------------GSMN---------------------------------------- -------------VT-LVVITIL------------------------------------------------- ---------------------------------------------------------E-TP--------YVM ------------------------------------------------------------------------ -------MHYGKNF-T-------------GNERF---------------------------YGFC-V----- ------------DILETISR-E----------------------V----G----------F----------- ------------D----YILDL-VPD---------RK-YGAKD----------------------------- -----------------------------------------PETG----Q---W------------------ NG------------------------MVA---QL--------------MK-Y--------------K---AD LAVG-----------------------------------------------------------SMTIT---- -YAR---ESV--I-----------DF-T-KP-----FMNLG---ISI-------------LFKVP------- --------------------------------ASE-PT--RLFS-------------FMNP---LA------ ----------------------------------IEI--W-LYV-LIA-------YF-L---VS-----ICI YVVGKL------------------------------------------------------------------ --------------------SPLE-WKC-------------------------------------------- -----I------------------------------HPCD-----------------LDNI----------- ------------------------------------------------------------------------ ----------------------------------SIGN-QF------------------------------- ---------------------------------SLTD-----SFWF---TIE--------TLM-----QQS- ---------TDIY-PRAMSTRIISSI------WGF-----FSLIIVASYTA-----NL-----AA-FLTTER M--IN-----------------------PIE-----NADDLASQT----------------------EIS-- -----------YGTLD---------SGSTM---------------TFF----R------------------- -------------DSMIE-------------------------------------------TYKKI------ -WRSMDNK---KPSA-------------------------------------------FTTTYED--G---- IKRVNQ-----------G-------K-Y-A-FLMESTMLDY--------------------IVQRDCN---- -----LTQIGGL-LDT-KG-------------------------------------------------YGIA TPKG-S-P-------------------------WRDKISLA-----------ILELQERGDIQM-------- ---L---------------YDKWW-------------KN-------------TDET--CTRKNTSKQS---- -----------------------KANALGLESIGSI------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >NP_001036250.1_Dmel_Kainate/1-899 ------------------------------------------------------ML---------------- ---------------------------------------------------------IASGFLLF------- ----------------QFLS---------------------------------------------YGLGVPP LVRIG------------------------------------------------------------------- -------------------------AIFSNQPGM-------------------------------------- ---------------YNSELAFRYAI-----------HRLNMDKSL------------------LPETTV-- --DYYVEYVNRFDSFET--VQKVCK-LI--------RVGVQAVF---------------------------- ---------------------------------------------------------------------SPT -DSV--------------------LATHINSICDALDI-----------------PNI---GR--------- ----SAHDFSINV---YPSKQLVNY--------AFNDV---IQY-LN------WTRF--------------- -----------------------------G--------ILHE-KENG------------------------- ------------------------IINLH--QLSRSFHGEV-----------------------HMRQV--- --------------------------SRDSY-----------VSALNEFKGKEIHN---------------- --------III-------DTN--SNGIS-------------------------------------------- -----------------------ILL-----------KNI------------LQQ---QMNE---------- ----YKY--HYLFT----------------------------------------------SFDLETY----- -DLEDFKYNFV------NITSFRLVD------------------------TADVGVKQILKDIG-------- ----LYSHHIFKKPYLNLHIKKS-----TIL----------------------------------------- -----------ESEPALMF----D--------------------------------SVYVF-A--------- ----IGLQ--TLEQSH---------------------------------------SLTLLNISCE------- ------EENS-WDGGLSLINY---------------------------LNAVEWK----------------- -------GLTGPIQFKD-GQ---------------------------------------------------- ------------------RVQFKLDLIKLKQ--------------------------------HS------- -IVKVGEW--------------------------------------------------TPHG---------- ---------------------------------------------HLNIT-EPSMFFDA------------- ----------------------------GSMN---------------------------------------- -------------VT-LVVITIL------------------------------------------------- ---------------------------------------------------------E-TP--------YVM ------------------------------------------------------------------------ -------MHYGKNF-T-------------GNERF---------------------------YGFC-V----- ------------DILETISR-E----------------------V----G----------F----------- ------------D----YILDL-VPD---------RK-YGAKD----------------------------- -----------------------------------------PETG----E---W------------------ NG------------------------MVA---QL--------------MK-Y--------------K---AD LAVG-----------------------------------------------------------SMTIT---- -YAR---ESV--I-----------DF-T-KP-----FMNLG---ISI-------------LFKVP------- --------------------------------TSE-PT--RLFS-------------FMNP---LA------ ----------------------------------IEI--W-IYV-LIA-------YF-L---VS-----LCI YIVGKL------------------------------------------------------------------ --------------------SPIE-WKC-------------------------------------------- -----I------------------------------NACD-----------------LENI----------- ------------------------------------------------------------------------ ----------------------------------SIGN-QF------------------------------- ---------------------------------SLTD-----SFWF---TIG--------TFM-----QQS- ---------PDIY-PRAMSTRIISST------WGF-----FSLIIVASYTA-----NL-----AA-FLTTER M--IN-----------------------PIE-----NAEDLASQT----------------------EIS-- -----------YGTLD---------SGSTM---------------TFF----R------------------- -------------DSVIE-------------------------------------------TYKKI------ -WRSMDNK---KPSA-------------------------------------------FTTTYED--G---- IKRVNQ-----------G-------N-Y-A-FLMESTMLDY--------------------IVQRDCN---- -----LTQIGGL-LDT-KG-------------------------------------------------YGIA TPKG-S-P-------------------------WRDKISLA-----------ILELQERGDIQM-------- ---L---------------YDKWW-------------KN-------------TDET--CTRKNTSKQS---- -----------------------KANSLGLESIGGVFVVLI-------------AGIIV-AAV----VAFFE FW---------------------------------YNFRY-------N-YEATPSQSVVNNKYNQ------- ---------------DGILESERN---YTPPD---------------------------------------- -----------------------------------RSFWIEIAEELRYASWC---------------M-NKQ KRPALTRTC--------------------------------------------------------------- -----------------------------------------------------SKCT--------------- -----------IPKGQ-------------------------------------------------------- ------------------------------------------------------RINKL------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap_1512159_IR1067/1-705 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------MAAAVW--------------------------------------------- ---------LRVGPLLL--VV-M------------------VLLPGCG------------------------ -----------------------------------------------------------------------A QGGQAA-----------------------------MES---------------------------------- ----------------------LLR--------TIVQKGL-------------------------------- ------------------------KDCHLA--------IVG----YG------------------------- --------------------PSVIASILR--GLDGSGV-------------------------SILPRTVVD VAE---------------------SWQGRG-------------DLMAGVV-RGDLRAAC------------- ------RLLVV------QAKG--AGKED-------------------------------------------- ------------------------VF-----------QFL------------EVA---RLYE---------- ----WEK-TFVVLV----------------------------------------------GEDEKET----- ------------------------------------------------------------------------ ----KEEDVKGN-------------DIEEILLHH--------TF---------------------------- ---------RNTHFLLYLVPLPSNSL---------------------H--------PVHQL----------- --------------------------------H--------------------------------------- ----------PATNTSTVTATASV---------------AIVRDKRMEFIDALFV----------------- ---------------------------------------------TSTATQKTNGTGQ-------------- ---------------------VKVYTRCLYC-----------------------------------DG-GSP AVRLLYTW--------------------------------------------------KHSSPQQP------ ------------------------------------------------------------------------ ------------------------------TKTT---T-F------FPGP--------LRS----------- 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---W---------------LDQLV-------------LTPH----------PSTPATASQQTLIPQE----- -------------------EEGAARVVLGMGHLQGAFYLLI-------------IGLGL-AFV----AFLVE AL---------------------------------PW----------------------------------- ------------------------------------------------------------------------ ---------------------------------F-------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------RRQEDKK------------ -------------------------------------------------------ST--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_1869847_IR1067/1-711 ------------------------------------------------------MFV--------------- ---------------------------------------------------L-RMVVARMLVLVV------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------PPLAAE----------------------------------------------- -----------VRPRFV--SETS------------------SLVGIVP------------------------ -----------------------------------------------------------------------E LSGLAV--------------AAGDPL--------DVSD---------------------------------- ----------------------LVA--------GIIKEHL-------------------------------- ------------------------STCHLV--------VVTP-TDHH------------------------- --------------------P-VFTPVLR--VLRET----------------------------YMPYLVVD ARH------------------ALSYPEGH---------------LLQALK-KGDRRFSC------------- ------RAFLV------DLSL--RSTAT-------------------------------------------- -----------------------LAF-----------DLL------------ERV---DLHL---------- ----RPY-TRVLFL----------------------------------------------GGSEG------- ------------------------------------------------------------------------ --------------------------VQEALRHH--------AL---------------------------- ---------RNTAHALYLA----------------------------------------------------- ------------------------------------------------------------------------ ------LDDLQARDFLTLRVRGGM---------------AGRRSV---------N----------------- ---------------------------------------------EDVPAGDGDGGGR-------------- -------------------RWVHCYSRCLYC-----------------------------------DS-GHV DVILLDQW--------------------------------------------------SPLTGFK------- ------------------------------------------------------------------------ -------------------------------KGI---K-L------FPDQ--------FRD----------- ----------FMGHT-FKIVTLD------------------------------------------------- ----------W------------------------------------------------FP--------FME -----------------------------------------FR----------------------------- -----------RDSDA------------EA-------------------------TTVTPQDSID-V----- ------------RMLTAISH-A----------------------L----N----------F----------- ------------T----YEMRV-PWD---------NQ-WGT------------------------------- -----------------------------STESG---------------N---W------------------ TG------------------------VVG---TL--------------QH-H--------------K---AD FSMV------------------------------------------------------------LSWM---- -RGR---YQV--V-----------DY-T-RI-----YASEP---IVM-------------I-MSK------- --------------------------------PRP-LP--QYL-------------ALVRP---FT------ ----------------------------------GAL--W-AAV-FVS-------SV-S---AG-----LIL WALQRG------------------------------------------------------------------ -------------------WSRAS------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------GRRG---L------------------------------ ---------------------------------PLDI-----SVLY---TWS--------ILF-----EEP- --------P-PGI-PTNTSGQMFVGW------WWL-----YCTIITVVYRS-----SL-----IA-HLSVPG T--SP-----------------------AID-----SFQQLVQ----------------------EDGWS-- -----------WGYEP---------SYGAGW--------------EWF----K------------------- -------------R----------------------------------NT-NP--------TIQTI------ -FQGME----------------------------------------------------VMEFPEQ------- MERVL----------K-G-------Q-H-A-LITWKYKIKSLIAALYTDD-------------FGYTP---- -----IYIAREEYFNY------------------------------------------GG--------YGWS FRKG-T-P-------------------------FRRAIDMQ-----------KQRLIESGFISH-------- ---W---------------MNELI-------------GS-------------AAKKAREEQTGDSQQVE--- ---------EWKRD-QQDKEEG-GRVVLSMHHLQGVFYLLG-------------LGFSG-ALL----VLVGE TI---------------------------------TH----------------------------------- ------------------------------------------------------------------------ ---------------------------------IC------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------GRKKRTTQ------------ -------------------------------------------------------LTATGE----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap_11154011_IR1069/1-764 ------------------------------------------------------------------------ -------------------------------------------------------MMLMAVVMVL------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------VAAV----------------------------------------------- -------------PQVL--TKPP------------------ATLRPAR------------------------ ------------------------------------------------------------------------ ---------------------------------HPLGS---------------------------------- ----------------------TVG--------QVVEQHL-------------------------------- ------------------------AGCHLV--------AATW-HRHS------------------------- --------------------L-GLDNVLS--SLESF----------------------------QIARIVLD ASILASHHATSNTTSSVTAASSSAAAAGKRPA---------SPQLWRRVM-EGQR-RNC------------- ------RAVIL------DVTD--SSSSSSSSSSSSSSSSWLPSSPSPPQVSSSPSPPPSPSPSSSSSSTSSP LNTSSLSANVAYSSTS--VSKIDQLM-----------SFL------------------HLSL---------- ----WPA-TRVVAL----------------------------------------------G-SYQAA----- ------------------------------------------------------------------------ ----E-----------------------PVLASN--------AL---------------------------- ---------RNTAHALYFA----PS----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------T----------------- ---------------------------------------------S-----TCGRKVG-------------- -----------------CVKLV---SRCMYC-----------------------------------SPGGVP GVRVSPMW--------------------------------------------------RAEQPLP------- ------------------------------------------------------------------------ -------------------------------RDL---Q-L------FPGG--------FED----------- ----------MYGHS-VRVVAKT------------------------------------------------- ----------L------------------------------------------------FP--------FME -----------------------------------------FE----------------------------- -----------RHEPT------------PG-------------------------APVTPMDSLD-V----- ------------RMLNTVAE-I----------------------L----N----------F----------- ------------T----YVVRP-PKD---------EQ-WGT------------------------------- -----------------------------YVD-G---------------V---W------------------ TG------------------------MVG---TL--------------EA-E--------------E---AD VSMM------------------------------------------------------------LFWS---- -YAR---KQV--I-----------DF-T-RI-----YTNEP---FVM-------------I-TRK------- --------------------------------PRP-LP--QHL-------------ALVRP---FS------ ----------------------------------MVV--W-VAV-LFG-------TM-L---AG-----CSL WALQKT------------------------------------------------------------------ -------------------WASFS------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------GGYA---P------------------------------ ---------------------------------SLNT-----AIMN---VWG--------MLL-----EDP- --------P-VTM-PSNITGQMLVGW------WWL-----FCLLLTASYRS-----SL-----IA-HLSVPT T--PP-----------------------PID-----TLKQLLS----------------------VPGAT-- -----------WGIEP---------GFGLGW--------------DWF----K------------------- -------------L----------------------------------NQ-NP--------EVQAM------ -FKTLQ----------------------------------------------------VMNVADQ------- MPYVL----------K-G-------R-H-A-FFTWKYYIKTIVASSYTNL-------------KGVTP---- -----IHMGREE-FVP------------------------------------------GS--------TGWG VRKG-L-P-------------------------FLPPMDRI-----------HDQLVEAGLVSH-------- ---W---------------LDELF-------------ET-------------AMKKARKMAAEAQAEAERKG EKVDTS---LLSDDDSSGGD----QLVLTLNHLQGAFYLLM-------------LGVGV-ACV----LLVGE NL---------------------------------VA----------------------------------- ------------------------------------------------------------------------ ---------------------------------RSFPSQFTASR---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------DLPVEK-------------------------------------------------------- -----------------------------------------------RL---SKHTNTLR------------ -------------------------------------------------------L---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla_194176_IR1069/1-729 ------------------------------------------------------MWSE-------------- ---------------------------------------------------F-AVVVLATVVVVQ------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------DAGNATL----------------------------------------------- -------------GQVV--VNAA------------------QVMKTEQV----------------------- ----------------------------------------------------------------------AE ETGQVAHK---------LDQVVEDADQS----VKRVGQ---------------------------------- ----------------------VVQ--------QVVEQYL-------------------------------- ------------------------AGCHLV--------VVTP-QVHS------------------------- --------------------P-AFTDILR--WLTAG----------------------------QQASVVVD LRTLLPAGLHYND-------------AGQSLA---------NDFTWKHLV-EGDAKLTC------------- ------RALLL------DLTS--QSYT--------------------------------------------- -----------------------EVL-----------EFL------------KEV---KLEL---------- ----WPK-TRVVGV----------------------------------------------G-STSRA----- ------------------------------------------------------------------------ ----W-----------------------EVLSHA--------SF---------------------------- ---------RYTIHALFLAAKPTPS----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------I----------------- ---------------------------------------------SSSAAAACDRSGA-------------- -----------------CGGEVWAYSRCLYC-----------------------------------SG-GKP GMRLVGTW--------------------------------------------------RPGQGFS------- ------------------------------------------------------------------------ -------------------------------LGR---S-L------FLEG--------FED----------- ----------MKGGL-VRVVAKD------------------------------------------------- ----------F------------------------------------------------FP--------FMK -----------------------------------------FD----------------------------- -----------RNTDE------------PG-------------------------SVVTPRDSVD-V----- ------------RLLNCVAE-G----------------------L----N----------F----------- ------------T----YEIRM-DLR---------DE-WGT------------------------------- -----------------------------VDN-G---------------T---W------------------ TG------------------------LIG---TV--------------VE-D--------------R---AD ISMM------------------------------------------------------------LFES---- -YPR---RQV--I-----------DF-T-RL-----YANEP---FIM-------------V-VHK------- --------------------------------PRS-QP--QYL-------------ALMRP---FT------ ----------------------------------VEL--W-VAV-LVA-------TF-V---VG-----GML WLLQKV------------------------------------------------------------------ -------------------WARSF------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------GQRG---L------------------------------ ---------------------------------NLST-----SLLY---MWS--------IML-----EEP- --------F-VHP-PPNITGQMVVGI------WWV-----FCLVITTMYRS-----SL-----VA-YLSVPI N--SA-----------------------PLD-----TIDQLLA----------------------HPDAT-- -----------WGMEP---------GFGLGW--------------DWF----K------------------- -------------F----------------------------------NT-NP--------KVQMV------ -FRKLK----------------------------------------------------ILDVEEQ------- MKEVM----------E-G-------N-H-A-FFTWKYYTKTIIAANFTDR-------------YGNTP---- -----LHISREE-FVQ------------------------------------------GS--------TAWG VRKG-L-P-------------------------FLEPMDRI-----------LDHLVESGLVNY-------- ---W---------------FQELF-------------RY-------------ATEKAREERMKVQRAGTSAG DWGTVDGEVVFSSDSKWAGLVGDNAVVLNLNHLQSAFYILL-------------LGYIV-ASL----VFLTE IF---------------------------------NP----------------------------------- ------------------------------------------------------------------------ ---------------------------------SSIIT---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------PTP--------------------------------------------------------- ----------------------------------------------------SPHPHPPK------------ -------------------------------------------------------M---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_1961593_IR1066/1-641 ------------------------------------------------------------------------ ---------------------------------------------------M-EIYLLTGIAVVT------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------LLGKTAS----------------------- ------------------------------------------------------------------------ AGDSLL------------PQVAGNVTLPQD-EQAQLAM---------------------------------- ----------------------FMN--------VLASKYT-------------------------------- ------------------------SRCLRA--------LVGD-AGYW------------------------- --------------------V----------------G-----------------------HWDHA-HVIIN PD----------------------YSQARNT-----------VDYMNENT-EKVTTYSC------------- ------VTYMM------TDIP--RP----------------------------------------------- -----------------------RLL-----------ASI------------TDL---SKKQ---------- ----MTR-YFLAYL----------------------------------------------NNVQQAH----- ------------------------------------------------------------------------ ----K------------------------FLLDD--------RL---------------------------- ---------KNEEHVAALV----------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------KL----------------- ---------------------------------------------RNNKKEE-------------------- -------------------WSWQVLTRQLLH-----------------------------------PS-GSP EVHVANMW--------------------------------------------------SQAQGLR------- ------------------------------------------------------------------------ -------------------------------ERG---E-L------FPEQ--------MKN----------- ----------FYGTK-LQGVTLD------------------------------------------------- ----------F------------------------------------------------RP--------FTD -----------------------------------------YE----------------------------- -----------KFPGT---------------------------------------RVVRPKPSLD-V----- ------------FILDVIAD-N----------------------L----N----------F----------- ------------T----YELVM-PED---------GL-WGY------------------------------- -----------------------------INDDG---------------H---W------------------ VG------------------------VVG---DV--------------EF-R--------------R---AN FSLV------------------------------------------------------------VSVT---- -LER---RIS--V-----------DF-T-RS-----YYRDP---LSF-------------V-TAK------- --------------------------------SRS-QP--PWL-------------KLFRP---FS------ ----------------------------------NEV--W-LLA-AAS-------VG-V---AV-----VMY YIIFRA------------------------------------------------------------------ -------------------QATLG------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------TPP----V------------------------------ ---------------------------------SASR-----AFMY---IFG--------SFL-----SQA- --------L-FVI-PWLSAGQVLLSF------WFI-----YALLLTTYYKT-----SL-----TA-ALAVPS A--PP-----------------------TID-----TLDQLI-----------------------RSNLE-- -----------YGMID---------AKGSEY--------------QLF----S------------------- -------------S----------------------------------SN-VP--------LYQEM------ -FKHMN----------------------------------------------------YYSSAES------- MNLVA----------E-G-------K-Y-A-YIYFKSNLETIVTTQYTSM-------------NGETD---- -----LHVAYEE-FFP------------------------------------------GG--------YGWA FPKG-A-P-------------------------YRRTFDDV-----------MWRCVQGGLIAK-------- ---W---------------MKDLH-------------YI-------------YLEEAMEQKTPEDREAERQ- ---------------VALNKGGDSRVVLDLNHLQGPFLALL-------------LGSSA-GIF----FLLVE LV---------------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------VYRVFGS------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap_1171100_IR1066/1-688 ------------------------------------------------------------------------ ---------------------------------------------------------MHGKVVVC------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------FLQVLLN----------------------- ----------------------------------------------------------------------HF AVGSFS------------SDTAENVIESADITDENLAK---------------------------------- ----------------------VMY--------LLADKYT-------------------------------- ------------------------PQCLWV--------VVSD-NTLH------------------------- --------------------Q----------------Q-----------------------PWRHS-HLTLD P------------------------KEGKNT-----------IDYINKNT-ERVTLFSC------------- ------FTFLM------TRPP--DS----------------------------------------------- -----------------------SLM-----------PFL------------TDS---SNMQ---------- ----LTR-YFIIQF----------------------------------------------FNESEAH----- ------------------------------------------------------------------------ ----D------------------------FLLDE--------RL---------------------------- ---------IDQENVAALV----------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------KT----------------- ---------------------------------------------DPRKA---------------------- --------------------SYKIMIRQLFH-----------------------------------SS-GST QVLVINRW--------------------------------------------------ERGKGFD------- ------------------------------------------------------------------------ -------------------------------NTD---N-I------FPEQ--------MKN----------- ----------FYGTK-LRGVTLD------------------------------------------------- ----------F------------------------------------------------RP--------FTD -----------------------------------------YL----------------------------- -----------KVRGS---------------------------------------RVVIPKPSLD-V----- ------------FMLEVIAD-T----------------------L----N----------F----------- ------------T----YELVM-PED---------GL-WGY------------------------------- -----------------------------LKDDG---------------H---W------------------ VG------------------------VVG---DV--------------EF-R--------------R---AN FSLV------------------------------------------------------------LSLT---- -LER---IFS--V-----------DF-T-RI-----YYNDP---LSF-------------V-TAK------- --------------------------------SRP-SP--PWL-------------KLIKP---FS------ ----------------------------------SGV--W-LLA-LLS-------IV-T---AV-----ILY YIIYQA------------------------------------------------------------------ -------------------QALLG------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------THY----L------------------------------ ---------------------------------VPSR-----AFMH---IFG--------TFV-----SQS- --------L-FTI-PWLSSGRVFLGF------WLL-----YGLLITTYYKT-----SL-----TA-ALAVPF V--PP-----------------------TLD-----TLKQLM-----------------------RSNLE-- -----------FGMID---------AKGSEY--------------QLF----S------------------- -------------T----------------------------------SD-VP--------LYQRM------ -FQEMS----------------------------------------------------FLSSSES------- MKKVQ----------Q-G-------R-Y-A-YIYFKSNLNIIVKTEYTNA-------------NGETD---- -----LHVASEE-FFP------------------------------------------GG--------YAWA FPKG-V-P-------------------------YRKTFDGV-----------MGYCLQAGLIDK-------- ---W---------------ERDLY-------------SI-------------YLKETQDNKTPQQIKKEKM- ---------------EANAKPNDGQVVLNLNHLQGPFLILL-------------LGSAS-GVL----LLLLE FF---------------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------VARMLFA------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------FPTSPKEQSKIS------------------------------------------------- ----------------------------------------------------EPSPFSQKTP-MNSDHQ--- ------------------------------------------------TSSPGGVVSGFDEKGNYVI----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------RTVLKGN----------------------------- >Csap_1856022_IR1064/1-656 --MGGATACLVVC----------------------------------------ALAGLGQ------------ ------------------------------------------------------VVGAA---LLPASFS--T L----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------VAGRVESRMSEVTEAQIL---------------------------------- ----------------------LTE--------VVIRE-M-------------------------------- ------------------------SGCAVV--------LLYD-TP-D------------------------- --------------------ALPVLA--P--TL----------------------------PLIPYGVSLVY LASLDATTAFAL-------------KNHMDIS---------DANVCRGV----------------------- ---------VV-------AAR--DR-------------SW-------------------------------- -----------------------GRL----------LQETSH-------LWVGHT----------------- --------LTFLLL----------------------------------------------LSDEDLT----- ------------------------------------------------------------------------ ---R-DAP--------------------SLLLHP--------TF---------------------------- ---------RFGAQVVAA------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------ARQD-N------------------ -------------------VSWQLHTTSL---------F---------------------------SSHHRH HTTPLDTW--------------------------------------------------RPIQGFR------- ------------------------------------------------------------------------ -------------------------------KGA---Q-L------FPED-K------MNN----------- ----------MQGFT-FTVAALP------------------------------------------------- ---------------------------------------------------------Y-DP--------FIT -----------------------------------------AA----------------------------- ---------------D------------------------------------TTLTGPGKYRGLE-V----- ------------RLLDVLAE-A----------------------A----N----------F----------- ------------T----YRYVA-PKD---------RQ-WGR------------------------------- -----------------------------LKKDG---------------T---W------------------ TG------------------------MIG---MV--------------AG-E--------------A---AD WAMS-----------------------------------------------------------DITFS---- -PQR---EEY--V-----------DF-S-RT-----FVYDA---SEL-------------V-TPR------- --------------------------------AKP----LPRWT------------SPTRP---FQ------ ----------------------------------WEV--W-VAV-VIV-------VA-A---AG-----PFL CILAR------------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------VCT-----------------DTY------------ ------------------------------------------------------------------------ ---------------------------------LSRVT-WFH------------------------------ ---------------------------------HLGN-----SILF---IIQ--------PVL-----QRG- --------G-DKD-IVIAPGRMFFGF------WLV-----FAMIVGISYSS-----SL-----TS-FLIMPG L--QK-----------------------PIE-----NLHQLVTSDIG-WAKVYFGGVQSALLDQAQDPDL-- -----------IALRE---------GVQWR---------------DSL------------------------ ---------------------------------------------------SG--------ILQEVVEGKLA TWDNGITT---RL-----LV-------------------------------------ASKFTDTA--G---- QPLVH----------F-P-------N-F-H-LLLER------------------------------------ --------------------------------------------------------------------IAWP LQQH-A-P-------------------------YKRRLDQL-----------IDQVVGAGLVEKWLEFIIFE EQAL---------------SRREK-------------ERGGT-------AIEAVEGT---TGGTV------- --------------------------ILSLEHFQGPFFVLL-------------LGCLC-GGV----ALLLE IS---------------------------------VR-VL-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------YRTEIK----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla_1590173_IR1064/1-475 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------MWRRVGRRPSVEVEARQL---------------------------------- ----------------------LAE--------VVERE-M-------------------------------- ------------------------TGCSLM--------LLFD-SH-P------------------------- --------------------GLSPLP--Q--PL----------------------------QQHALGVSLVH VPSLAPEVVFQL-------------KGAPRSS---------ESRVCGGV----------------------- ---------VV-------VAS--AGD-----------EAW-------------------------------- -----------------------PWL----------VAGGVG-------AWAGHA----------------- --------HTFLLI----------------------------------------------MPREGEE----- ------------------------------------------------------------------------ ---R-DALDLT----------------SSILLHP--------DF---------------------------- ---------RFGAQVVAA------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------TRDT-D------------------ -------------------GSWSVYTTTL---------F---------------------------SGDARI SLARVGTW--------------------------------------------------SPSSGFW------- ------------------------------------------------------------------------ -------------------------------QDV---R-L------FPED-K------MAD----------- ----------LRGYT-FSVAALT------------------------------------------------- ---------------------------------------------------------Y-SP--------FIM -----------------------------------------NA----------------------------- ---------------D------------------------------------PSLSGPGKYRGLE-V----- ------------RLLDVLAA-T----------------------A----N----------F----------- ------------T----YRYVA-PED---------SQ-WGR------------------------------- -----------------------------RDHNG---------------T---W------------------ TG------------------------MIG---MV--------------IH-E--------------Q---AD WAVS-----------------------------------------------------------DITFS---- -AQR---ELY--V-----------DF-C-QP-----FVYDA---SEL-------------V-TPR------- --------------------------------AKP----LPRWL------------GPVRP---FT------ ----------------------------------WQV--W-LGV-GVA-------VG-V---AA-----PFL CAVARL------------------------------------------------------------------ --------------------SALL------------------------------------------------ ------------------------------------TNTH-----------------GA------------- ------------------------------------------------------------------------ -------------------------------------T-WFK------------------------------ ---------------------------------KIKN-----AAMF---VVE--------PVF-----QRG- --------T-KRG-IKVVPGRVFSGF------WLI-----FCMIVGISYSS-----SL-----TS-FLITPG L--QR-----------------------PIQ-----NLHQLVTSDIG-WAKVFFGGIQNDLLEETHDPVL-- -----------IALRQ---------GVQWR---------------D-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame_12020403_IR1064/1-675 --MAPCGSRIPVW----------------------------------------WLLALVV------------ ------------------------------------------------------LVGLVN--TAVASLA--S V----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------ISGRVWQRPDEEEEARHL---------------------------------- ----------------------VGE--------VVERE-L-------------------------------- ------------------------GRCSLV--------VLHD-SH-P------------------------- --------------------VLTPLP--P--PL----------------------------RHHSLGLSLVH LLTLNPPTVFEL-------------KSNVQVN---------DTRVCRGV----------------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MERRPG RIVRDSP----IPE--------------------------------------------------------DS HNLPRR-------------RGGKAVVVVRTQPKMK------------------------------------- ----------YLKPLFYVMPVLLPVLI-------------------------------K---WKVLADEDSW -RTYPHPIRNVNTLQTF--IKKKLNEKNDQFVRDDED-FRGIIYNNRSQNAVTM------------------ ------------------------------------------------------------------LDPDPS SIKNTI----------IVTNEANSDEDAQIKEDECLDG---------------------------------- ---------------WVTRPEKLGVRAG----QILNHLGV----------PS-------------------- ----------------------------FA--------LVTQ-CE--------------------------- -------------------------------------------------------------AGWVLVTTRLL LQE--------------------AGEKGVSSCL-FD----SVSSMKKAVM-TSPYDARC------------- 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